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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-oxo-Delta(1),Delta(4)-steroid
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Accession:CHEBI:77166 term browser browse the term
Definition:A 3-oxo-Delta(1) steroid containing an additional double bond between positions 4 and 5.
Synonyms:related_synonym: 3-oxo-Delta(1),Delta(4)-steroids;   3-oxo-Delta(1,4)-steroid;   3-oxo-Delta(1,4)-steroids;   Formula=C19H25OR;   SMILES=C12(C=CC(C=C1CCC3C2CCC4(C3CCC4*)C)=O)C;   a 3-oxo-Delta(1,4)-steroid


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betamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX2 heme oxygenase 2 increases expression EXP Betamethasone results in increased expression of HMOX2 protein CTD PMID:11698254 NCBI chr 3:37,829,044...37,868,163
Ensembl chr 3:37,831,434...37,868,128
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Betamethasone results in decreased expression of PTGS2 protein CTD PMID:11698254 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
dexamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA CTD PMID:30481989 NCBI chr 6:79,589,695...79,649,646
Ensembl chr 6:79,588,659...79,649,648
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of BCL2L1 mRNA CTD PMID:30481989 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Troglitazone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CASP3 mRNA CTD PMID:30481989 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha increases expression
multiple interactions
EXP Dexamethasone results in increased expression of CEBPA mRNA
[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA]
CTD PMID:11225715 PMID:30481989 NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,203...43,085,836
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL1A1 mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL1A1 mRNA CTD PMID:30481989 NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,003
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA] CTD PMID:30481989 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression EXP Dexamethasone results in increased expression of CYP17A1 CTD PMID:19852296 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G FABP4 fatty acid binding protein 4, adipocyte multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA] CTD PMID:30481989 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA] CTD PMID:30481989 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions EXP [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA] CTD PMID:30481989 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,925...137,690,666
JBrowse link
G IRS1 insulin receptor substrate 1 decreases expression EXP Dexamethasone results in decreased expression of IRS1 mRNA CTD PMID:19852296 NCBI chr15:128,245,846...128,307,321
Ensembl chr15:128,245,846...128,308,335
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
EXP Dexamethasone results in increased expression of PPARG
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]
CTD PMID:19852296 PMID:30481989 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA CTD PMID:30481989 NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,513...40,459,686
JBrowse link
G SLC2A4 solute carrier family 2 member 4 decreases expression EXP Dexamethasone results in decreased expression of SLC2A4 mRNA; Dexamethasone results in decreased expression of SLC2A4 protein CTD PMID:19852296 NCBI chr12:52,628,746...52,634,965
Ensembl chr12:52,628,450...52,634,967
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA]; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA] CTD PMID:30481989 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 902
    chemical entity 902
      group 867
        organic group 392
          3-oxo-Delta(4)-steroid group 50
            3-oxo-Delta(4) steroid 50
              3-oxo-Delta(1),Delta(4)-steroid 17
                (22E)-24nor-cholesta-1,4,22-trien-3-one 0
                24-methylenecholesta-1,4-dien-3-one 0
                3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid 0
                6-methylprednisolone + 0
                9alpha-hydroxy-3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid 0
                9alpha-hydroxyandrosta-1,4-diene-3,17-dione 0
                Delta(1)-progesterone + 0
                alclometasone 0
                alclometasone dipropionate 0
                amcinonide 0
                androsta-1,4,6-triene-3,17-dione 0
                beclomethasone + 0
                beclomethasone dipropionate 0
                betamethasone + 2
                betamethasone acetate 0
                betamethasone acibutate 0
                betamethasone dipropionate + 0
                betamethasone phosphate 0
                betamethasone valerate 0
                boldenone 0
                budesonide 0
                clobetasol + 0
                clobetasol propionate 0
                clocortolone + 0
                clocortolone pivalate 0
                cortancyl 0
                desonide 0
                desoximetasone 0
                dexamethasone + 15
                diflorasone + 0
                diflorasone diacetate 0
                exemestane 0
                flumethasone + 0
                flumethasone pivalate 0
                flunisolide 0
                fluocinolone acetonide 0
                fluorometholone + 0
                fluorometholone acetate 0
                fluticasone furoate + 0
                fluticasone propionate 0
                loteprednol + 0
                loteprednol etabonate 0
                methyl prednisolone-16-carboxylate + 0
                methylprednisolone 21-suleptanic acid ester 0
                methylprednisolone acetate 0
                minabeolide 1 0
                minabeolide 2 0
                minabeolide 4 0
                mometasone + 0
                mometasone furoate 0
                paraminabeolide A 0
                paraminabeolide B 0
                paraminabeolide C 0
                paraminabeolide D 0
                paraminabeolide E 0
                prednisolone + 0
                prednisolone phosphate 0
                prednisolone succinate 0
                prednisolone-16-carboxylic acid + 0
                prednisone + 0
                testolactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 902
    subatomic particle 887
      composite particle 887
        hadron 887
          baryon 887
            nucleon 887
              atomic nucleus 887
                atom 887
                  main group element atom 856
                    p-block element atom 853
                      carbon group element atom 829
                        carbon atom 828
                          organic molecular entity 828
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      ketone 183
                                        oxo steroid 52
                                          3-oxo steroid 50
                                            3-oxo-Delta(1) steroid 17
                                              3-oxo-Delta(1),Delta(4)-steroid 17
                                                (22E)-24nor-cholesta-1,4,22-trien-3-one 0
                                                24-methylenecholesta-1,4-dien-3-one 0
                                                3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid 0
                                                6-methylprednisolone + 0
                                                9alpha-hydroxy-3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid 0
                                                9alpha-hydroxyandrosta-1,4-diene-3,17-dione 0
                                                Delta(1)-progesterone + 0
                                                alclometasone 0
                                                alclometasone dipropionate 0
                                                amcinonide 0
                                                androsta-1,4,6-triene-3,17-dione 0
                                                beclomethasone + 0
                                                beclomethasone dipropionate 0
                                                betamethasone + 2
                                                betamethasone acetate 0
                                                betamethasone acibutate 0
                                                betamethasone dipropionate + 0
                                                betamethasone phosphate 0
                                                betamethasone valerate 0
                                                boldenone 0
                                                budesonide 0
                                                clobetasol + 0
                                                clobetasol propionate 0
                                                clocortolone + 0
                                                clocortolone pivalate 0
                                                cortancyl 0
                                                desonide 0
                                                desoximetasone 0
                                                dexamethasone + 15
                                                diflorasone + 0
                                                diflorasone diacetate 0
                                                exemestane 0
                                                flumethasone + 0
                                                flumethasone pivalate 0
                                                flunisolide 0
                                                fluocinolone acetonide 0
                                                fluorometholone + 0
                                                fluorometholone acetate 0
                                                fluticasone furoate + 0
                                                fluticasone propionate 0
                                                loteprednol + 0
                                                loteprednol etabonate 0
                                                methyl prednisolone-16-carboxylate + 0
                                                methylprednisolone 21-suleptanic acid ester 0
                                                methylprednisolone acetate 0
                                                minabeolide 1 0
                                                minabeolide 2 0
                                                minabeolide 4 0
                                                mometasone + 0
                                                mometasone furoate 0
                                                paraminabeolide A 0
                                                paraminabeolide B 0
                                                paraminabeolide C 0
                                                paraminabeolide D 0
                                                paraminabeolide E 0
                                                prednisolone + 0
                                                prednisolone phosphate 0
                                                prednisolone succinate 0
                                                prednisolone-16-carboxylic acid + 0
                                                prednisone + 0
                                                testolactone 0
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