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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gypenoside LXXV
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Accession:CHEBI:77156 term browser browse the term
Definition:A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Synonyms:exact_synonym: (beta,12beta)-3,12-dihydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
 related_synonym: Formula=C42H72O13;   InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,55-37-35(51)33(49)31(47)25(54-37)20-52-36-34(50)32(48)30(46)24(19-43)53-36)22-11-16-41(7)29(22)23(44)18-27-39(5)15-13-28(45)38(3,4)26(39)12-17-40(27,41)6/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36+,37-,39-,40+,41+,42-/m0/s1;   InChIKey=YIYRCZFIJNGYOG-QINBLQPGSA-N;   SMILES=CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C
 xref_mesh: MESH:C000719168
 xref: MetaCyc:CPD-15460;   PMID:20622122;   PMID:22450790;   PMID:22805203;   PMID:22911093;   PMID:23717145



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gypenoside LXXV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO gypenoside LXXV results in increased phosphorylation of AKT1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased phosphorylation of AKT1 protein]
CTD PMID:35192202 PMID:36325883 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein] CTD PMID:35192202 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
increases expression
ISO gypenoside LXXV results in increased expression of and results in increased secretion of CTGF protein
gypenoside LXXV results in increased expression of CTGF mRNA
CTD PMID:31018484 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein] CTD PMID:33050067 PMID:35192202 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein] CTD PMID:35192202 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
ISO gypenoside LXXV results in decreased phosphorylation of IRS1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein
CTD PMID:35192202 PMID:36325883 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lepr leptin receptor multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein] CTD PMID:35192202 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO gypenoside LXXV binds to and affects the localization of NR3C2 protein CTD PMID:31018484 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO
EXP
gypenoside LXXV results in increased expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV binds to and results in increased activity of PPARG protein]; gypenoside LXXV binds to and results in increased activity of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of PPARG protein]
CTD PMID:35192202 PMID:36325883 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of RELA protein CTD PMID:33050067 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
multiple interactions
increases expression
ISO gypenoside LXXV affects the localization of SLC2A4 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of SLC2A4 protein]
CTD PMID:35192202 PMID:36325883 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO gypenoside LXXV results in decreased expression of TGFB1 protein CTD PMID:33050067 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]; gypenoside LXXV inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:33050067 PMID:35192202 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        epitope 7028
          beta-D-glucose 1650
            beta-D-glucoside 1456
              gypenoside LXXV 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            heteroorganic entity 19529
                              organochalcogen compound 19280
                                organooxygen compound 19189
                                  carbohydrates and carbohydrate derivatives 15063
                                    carbohydrate 15063
                                      monosaccharide 4798
                                        aldose 3207
                                          aldohexose 2860
                                            glucose 2820
                                              D-glucose 2820
                                                D-glucopyranose 1800
                                                  beta-D-glucose 1650
                                                    beta-D-glucoside 1456
                                                      gypenoside LXXV 13
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