CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sinapic acid
Accession: CHEBI:77131
browse the term
Definition: A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.
Synonyms: exact_synonym: 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
related_synonym: 3,5-dimethoxy-4-hydroxycinnamic acid; Formula=C11H12O5; InChI=1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13); InChIKey=PCMORTLOPMLEFB-UHFFFAOYSA-N; SMILES=COc1cc(C=CC(O)=O)cc(OC)c1O
xref: CAS:530-59-6; DrugBank:DB08587; KEGG:C00482
xref_mesh: MESH:C073734
xref: Wikipedia:Sinapinic_acid
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
sinapinic acid analog results in increased expression of ACOT2 mRNA
CTD
PMID:36279966
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of AGER mRNA]
CTD
PMID:37471654
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Apaf1
apoptotic peptidase activating factor 1
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of APAF1 mRNA]
CTD
PMID:37471654
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Arhgef19
Rho guanine nucleotide exchange factor 19
decreases expression
ISO
sinapinic acid analog results in decreased expression of ARHGEF19 mRNA
CTD
PMID:36279966
NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:153,536,013...153,554,203
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Arhgef2
Rho/Rac guanine nucleotide exchange factor 2
increases expression
ISO
sinapinic acid analog results in increased expression of ARHGEF2 mRNA
CTD
PMID:36279966
NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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Atf3
activating transcription factor 3
increases expression
ISO
sinapinic acid analog results in increased expression of ATF3 mRNA
CTD
PMID:36279966
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atf4
activating transcription factor 4
increases expression
ISO
sinapinic acid analog results in increased expression of ATF4 mRNA
CTD
PMID:36279966
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]
CTD
PMID:33720507 PMID:37471654
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
CTD
PMID:33720507 PMID:37471654
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl3
BCL3, transcription coactivator
decreases expression
ISO
sinapinic acid analog results in decreased expression of BCL3 mRNA
CTD
PMID:36279966
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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Bcl9l
BCL9 like
decreases expression
ISO
sinapinic acid analog results in decreased expression of BCL9L mRNA
CTD
PMID:36279966
NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611
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Calr
calreticulin
increases expression
ISO
sinapinic acid analog results in increased expression of CALR mRNA
CTD
PMID:36279966
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Caskin1
CASK interacting protein 1
decreases expression
ISO
sinapinic acid analog results in decreased expression of CASKIN1 mRNA
CTD
PMID:36279966
NCBI chr10:13,512,684...13,533,380
Ensembl chr10:13,513,465...13,533,377
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Casp3
caspase 3
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; sinapinic acid inhibits the reaction [Methotrexate affects the localization of CASP3 protein]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
CTD
PMID:33720507 PMID:37471654
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in decreased activity of CAT protein]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of CAT protein]
CTD
PMID:33720507 PMID:37471654
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Chac1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
increases expression
ISO
sinapinic acid analog results in increased expression of CHAC1 mRNA
CTD
PMID:36279966
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
sinapinic acid analog results in increased expression of DDIT3 mRNA
CTD
PMID:36279966
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
increases expression
ISO
sinapinic acid analog results in increased expression of EIF4EBP1 mRNA
CTD
PMID:36279966
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Fam53b
family with sequence similarity 53, member B
decreases expression
ISO
sinapinic acid analog results in decreased expression of FAM53B mRNA
CTD
PMID:36279966
NCBI chr 1:187,500,061...187,591,186
Ensembl chr 1:187,500,066...187,591,186
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Fam78a
family with sequence similarity 78, member A
decreases expression
ISO
sinapinic acid analog results in decreased expression of FAM78A mRNA
CTD
PMID:36279966
NCBI chr 3:15,355,958...15,376,330
Ensembl chr 3:15,355,955...15,373,812
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Foxo6
forkhead box O6
decreases expression
ISO
sinapinic acid analog results in decreased expression of FOXO6 mRNA
CTD
PMID:36279966
NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573
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G6pd
glucose-6-phosphate dehydrogenase
decreases activity
ISO
sinapinic acid results in decreased activity of G6PD protein
CTD
PMID:25130191
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gprc5b
G protein-coupled receptor, class C, group 5, member B
decreases expression
ISO
sinapinic acid analog results in decreased expression of GPRC5B mRNA
CTD
PMID:36279966
NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
sinapinic acid inhibits the reaction [Methotrexate results in increased expression of GPT protein]
CTD
PMID:33720507
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gramd2a
GRAM domain containing 2A
increases expression
ISO
sinapinic acid analog results in increased expression of GRAMD2A mRNA
CTD
PMID:36279966
NCBI chr 8:60,079,744...60,117,788
Ensembl chr 8:60,080,338...60,115,842
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Hmox1
heme oxygenase 1
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in decreased expression of HMOX1 mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein]
CTD
PMID:33720507 PMID:37471654
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa1b
heat shock protein family A (Hsp70) member 1B
decreases expression
ISO
sinapinic acid analog results in decreased expression of HSPA1B mRNA
CTD
PMID:36279966
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Il1b
interleukin 1 beta
multiple interactions
ISO EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [sinapinic acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein]]; sinapinic acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
CTD
PMID:18841975 PMID:32742113 PMID:33720507 PMID:37471654
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Jdp2
Jun dimerization protein 2
increases expression
ISO
sinapinic acid analog results in increased expression of JDP2 mRNA
CTD
PMID:36279966
NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
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Lmtk3
lemur tyrosine kinase 3
decreases expression
ISO
sinapinic acid analog results in decreased expression of LMTK3 mRNA
CTD
PMID:36279966
NCBI chr 1:96,261,058...96,280,362
Ensembl chr 1:96,260,977...96,280,672
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Lzts1
leucine zipper tumor suppressor 1
decreases expression
ISO
sinapinic acid analog results in decreased expression of LZTS1 mRNA
CTD
PMID:36279966
NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
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Mapk14
mitogen activated protein kinase 14
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK14 mRNA]
CTD
PMID:37471654
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk15
mitogen-activated protein kinase 15
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK15 mRNA]
CTD
PMID:37471654
NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK8 mRNA]
CTD
PMID:37471654
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mb
myoglobin
multiple interactions
EXP
sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein]
CTD
PMID:32627257
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Mpo
myeloperoxidase
multiple interactions
EXP
sinapinic acid inhibits the reaction [Methotrexate results in increased expression of MPO protein]
CTD
PMID:33720507
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
increases expression
ISO
sinapinic acid analog results in increased expression of MTHFD2 mRNA
CTD
PMID:36279966
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Mvk
mevalonate kinase
increases expression
ISO
sinapinic acid analog results in increased expression of MVK mRNA
CTD
PMID:36279966
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]
CTD
PMID:37471654
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] sinapinic acid inhibits the reaction [lead acetate results in increased expression of NFKB1 mRNA]
CTD
PMID:18841975 PMID:37471654
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:18841975
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in increased expression of NLRP3 mRNA]
CTD
PMID:37471654
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nol4l
nucleolar protein 4-like
decreases expression
ISO
sinapinic acid analog results in decreased expression of NOL4L mRNA
CTD
PMID:36279966
NCBI chr 3:141,884,840...142,007,668
Ensembl chr 3:141,884,840...142,008,976
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:18841975
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NQO1 mRNA]
CTD
PMID:37471654
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Ogdh
oxoglutarate dehydrogenase
multiple interactions
EXP
sinapinic acid inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]
CTD
PMID:32627257
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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P2ry6
pyrimidinergic receptor P2Y6
decreases expression
ISO
sinapinic acid analog results in decreased expression of P2RY6 mRNA
CTD
PMID:36279966
NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808
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Pgd
phosphogluconate dehydrogenase
decreases activity
ISO
sinapinic acid results in decreased activity of PGD protein
CTD
PMID:25130191
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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Prr5
proline rich 5
decreases expression
ISO
sinapinic acid analog results in decreased expression of PRR5 mRNA
CTD
PMID:36279966
NCBI chr 7:115,795,351...115,837,880
Ensembl chr 7:115,813,954...115,834,834
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Prrt2
proline-rich transmembrane protein 2
decreases expression
ISO
sinapinic acid analog results in decreased expression of PRRT2 mRNA
CTD
PMID:36279966
NCBI chr 1:181,625,243...181,628,833
Ensembl chr 1:181,604,545...181,628,850
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] sinapinic acid inhibits the reaction [lead acetate results in increased expression of PTGS2 mRNA]
CTD
PMID:18841975 PMID:37471654
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD
PMID:18841975
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rnf145
ring finger protein 145
decreases expression
ISO
sinapinic acid analog results in decreased expression of RNF145 mRNA
CTD
PMID:36279966
NCBI chr10:29,006,391...29,050,788
Ensembl chr10:29,011,548...29,050,781
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Sema7a
semaphorin 7A (John Milton Hagen blood group)
decreases expression
ISO
sinapinic acid analog results in decreased expression of SEMA7A mRNA
CTD
PMID:36279966
NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536
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Sesn2
sestrin 2
increases expression
ISO
sinapinic acid analog results in increased expression of SESN2 mRNA
CTD
PMID:36279966
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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Slc1a4
solute carrier family 1 member 4
increases expression
ISO
sinapinic acid analog results in increased expression of SLC1A4 mRNA
CTD
PMID:36279966
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
sinapinic acid analog results in increased expression of SLC7A11 mRNA
CTD
PMID:36279966
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Sned1
sushi, nidogen and EGF-like domains 1
decreases expression
ISO
sinapinic acid analog results in decreased expression of SNED1 mRNA
CTD
PMID:36279966
NCBI chr 9:93,774,087...93,834,003
Ensembl chr 9:93,774,119...93,830,694
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Srcin1
SRC kinase signaling inhibitor 1
decreases expression
ISO
sinapinic acid analog results in decreased expression of SRCIN1 mRNA
CTD
PMID:36279966
NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040
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Stard4
StAR-related lipid transfer domain containing 4
increases expression
ISO
sinapinic acid analog results in increased expression of STARD4 mRNA
CTD
PMID:36279966
NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
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Tbxa2r
thromboxane A2 receptor
decreases expression
ISO
sinapinic acid analog results in decreased expression of TBXA2R mRNA
CTD
PMID:36279966
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [sinapinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]]; sinapinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]
CTD
PMID:18841975 PMID:32742113 PMID:33720507 PMID:37471654
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trib3
tribbles pseudokinase 3
increases expression
ISO
sinapinic acid analog results in increased expression of TRIB3 mRNA
CTD
PMID:36279966
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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