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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sinapic acid
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Accession:CHEBI:77131 term browser browse the term
Definition:A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.
Synonyms:exact_synonym: 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
 related_synonym: 3,5-dimethoxy-4-hydroxycinnamic acid;   Formula=C11H12O5;   InChI=1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13);   InChIKey=PCMORTLOPMLEFB-UHFFFAOYSA-N;   SMILES=COc1cc(C=CC(O)=O)cc(OC)c1O
 xref: CAS:530-59-6;   DrugBank:DB08587;   KEGG:C00482
 xref_mesh: MESH:C073734
 xref: Wikipedia:Sinapinic_acid



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sinapic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot2 acyl-CoA thioesterase 2 increases expression ISO sinapinic acid analog results in increased expression of ACOT2 mRNA CTD PMID:36279966 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of AGER mRNA] CTD PMID:37471654 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of APAF1 mRNA] CTD PMID:37471654 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Arhgef19 Rho guanine nucleotide exchange factor 19 decreases expression ISO sinapinic acid analog results in decreased expression of ARHGEF19 mRNA CTD PMID:36279966 NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:153,536,013...153,554,203
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO sinapinic acid analog results in increased expression of ARHGEF2 mRNA CTD PMID:36279966 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO sinapinic acid analog results in increased expression of ATF3 mRNA CTD PMID:36279966 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO sinapinic acid analog results in increased expression of ATF4 mRNA CTD PMID:36279966 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein] CTD PMID:33720507 PMID:37471654 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] CTD PMID:33720507 PMID:37471654 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO sinapinic acid analog results in decreased expression of BCL3 mRNA CTD PMID:36279966 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcl9l BCL9 like decreases expression ISO sinapinic acid analog results in decreased expression of BCL9L mRNA CTD PMID:36279966 NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611
JBrowse link
G Calr calreticulin increases expression ISO sinapinic acid analog results in increased expression of CALR mRNA CTD PMID:36279966 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Caskin1 CASK interacting protein 1 decreases expression ISO sinapinic acid analog results in decreased expression of CASKIN1 mRNA CTD PMID:36279966 NCBI chr10:13,512,684...13,533,380
Ensembl chr10:13,513,465...13,533,377
JBrowse link
G Casp3 caspase 3 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; sinapinic acid inhibits the reaction [Methotrexate affects the localization of CASP3 protein]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of CASP3 protein] CTD PMID:33720507 PMID:37471654 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in decreased activity of CAT protein]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of CAT protein] CTD PMID:33720507 PMID:37471654 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO sinapinic acid analog results in increased expression of CHAC1 mRNA CTD PMID:36279966 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO sinapinic acid analog results in increased expression of DDIT3 mRNA CTD PMID:36279966 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression ISO sinapinic acid analog results in increased expression of EIF4EBP1 mRNA CTD PMID:36279966 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fam53b family with sequence similarity 53, member B decreases expression ISO sinapinic acid analog results in decreased expression of FAM53B mRNA CTD PMID:36279966 NCBI chr 1:187,500,061...187,591,186
Ensembl chr 1:187,500,066...187,591,186
JBrowse link
G Fam78a family with sequence similarity 78, member A decreases expression ISO sinapinic acid analog results in decreased expression of FAM78A mRNA CTD PMID:36279966 NCBI chr 3:15,355,958...15,376,330
Ensembl chr 3:15,355,955...15,373,812
JBrowse link
G Foxo6 forkhead box O6 decreases expression ISO sinapinic acid analog results in decreased expression of FOXO6 mRNA CTD PMID:36279966 NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO sinapinic acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B decreases expression ISO sinapinic acid analog results in decreased expression of GPRC5B mRNA CTD PMID:36279966 NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in increased expression of GPT protein] CTD PMID:33720507 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gramd2a GRAM domain containing 2A increases expression ISO sinapinic acid analog results in increased expression of GRAMD2A mRNA CTD PMID:36279966 NCBI chr 8:60,079,744...60,117,788
Ensembl chr 8:60,080,338...60,115,842
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in decreased expression of HMOX1 mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein] CTD PMID:33720507 PMID:37471654 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO sinapinic acid analog results in decreased expression of HSPA1B mRNA CTD PMID:36279966 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [sinapinic acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein]]; sinapinic acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
CTD PMID:18841975 PMID:32742113 PMID:33720507 PMID:37471654 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jdp2 Jun dimerization protein 2 increases expression ISO sinapinic acid analog results in increased expression of JDP2 mRNA CTD PMID:36279966 NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
JBrowse link
G Lmtk3 lemur tyrosine kinase 3 decreases expression ISO sinapinic acid analog results in decreased expression of LMTK3 mRNA CTD PMID:36279966 NCBI chr 1:96,261,058...96,280,362
Ensembl chr 1:96,260,977...96,280,672
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 decreases expression ISO sinapinic acid analog results in decreased expression of LZTS1 mRNA CTD PMID:36279966 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK14 mRNA] CTD PMID:37471654 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK15 mRNA] CTD PMID:37471654 NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK8 mRNA] CTD PMID:37471654 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mb myoglobin multiple interactions EXP sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein] CTD PMID:32627257 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in increased expression of MPO protein] CTD PMID:33720507 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO sinapinic acid analog results in increased expression of MTHFD2 mRNA CTD PMID:36279966 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mvk mevalonate kinase increases expression ISO sinapinic acid analog results in increased expression of MVK mRNA CTD PMID:36279966 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA] CTD PMID:37471654 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]
sinapinic acid inhibits the reaction [lead acetate results in increased expression of NFKB1 mRNA]
CTD PMID:18841975 PMID:37471654 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18841975 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in increased expression of NLRP3 mRNA] CTD PMID:37471654 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nol4l nucleolar protein 4-like decreases expression ISO sinapinic acid analog results in decreased expression of NOL4L mRNA CTD PMID:36279966 NCBI chr 3:141,884,840...142,007,668
Ensembl chr 3:141,884,840...142,008,976
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18841975 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NQO1 mRNA] CTD PMID:37471654 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP sinapinic acid inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:32627257 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 decreases expression ISO sinapinic acid analog results in decreased expression of P2RY6 mRNA CTD PMID:36279966 NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO sinapinic acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Prr5 proline rich 5 decreases expression ISO sinapinic acid analog results in decreased expression of PRR5 mRNA CTD PMID:36279966 NCBI chr 7:115,795,351...115,837,880
Ensembl chr 7:115,813,954...115,834,834
JBrowse link
G Prrt2 proline-rich transmembrane protein 2 decreases expression ISO sinapinic acid analog results in decreased expression of PRRT2 mRNA CTD PMID:36279966 NCBI chr 1:181,625,243...181,628,833
Ensembl chr 1:181,604,545...181,628,850
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
sinapinic acid inhibits the reaction [lead acetate results in increased expression of PTGS2 mRNA]
CTD PMID:18841975 PMID:37471654 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18841975 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rnf145 ring finger protein 145 decreases expression ISO sinapinic acid analog results in decreased expression of RNF145 mRNA CTD PMID:36279966 NCBI chr10:29,006,391...29,050,788
Ensembl chr10:29,011,548...29,050,781
JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) decreases expression ISO sinapinic acid analog results in decreased expression of SEMA7A mRNA CTD PMID:36279966 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536
JBrowse link
G Sesn2 sestrin 2 increases expression ISO sinapinic acid analog results in increased expression of SESN2 mRNA CTD PMID:36279966 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO sinapinic acid analog results in increased expression of SLC1A4 mRNA CTD PMID:36279966 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO sinapinic acid analog results in increased expression of SLC7A11 mRNA CTD PMID:36279966 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sned1 sushi, nidogen and EGF-like domains 1 decreases expression ISO sinapinic acid analog results in decreased expression of SNED1 mRNA CTD PMID:36279966 NCBI chr 9:93,774,087...93,834,003
Ensembl chr 9:93,774,119...93,830,694
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 decreases expression ISO sinapinic acid analog results in decreased expression of SRCIN1 mRNA CTD PMID:36279966 NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO sinapinic acid analog results in increased expression of STARD4 mRNA CTD PMID:36279966 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
G Tbxa2r thromboxane A2 receptor decreases expression ISO sinapinic acid analog results in decreased expression of TBXA2R mRNA CTD PMID:36279966 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [sinapinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]]; sinapinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]
CTD PMID:18841975 PMID:32742113 PMID:33720507 PMID:37471654 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO sinapinic acid analog results in increased expression of TRIB3 mRNA CTD PMID:36279966 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        polyatomic entity 19787
          heteroatomic molecular entity 19743
            hydroxides 19320
              organic hydroxy compound 18948
                phenols 18634
                  sinapic acid 63
                    cis-sinapic acid 0
                    trans-sinapic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      monocarboxylic acid 17966
                                        alpha,beta-unsaturated monocarboxylic acid 13457
                                          cinnamic acids 2510
                                            hydroxycinnamic acid 1365
                                              monohydroxycinnamic acid 1022
                                                sinapic acid 63
                                                  cis-sinapic acid 0
                                                  trans-sinapic acid + 0
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