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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sinapic acid
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Accession:CHEBI:77131 term browser browse the term
Definition:A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.
Synonyms:exact_synonym: 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
 related_synonym: 3,5-dimethoxy-4-hydroxycinnamic acid;   Formula=C11H12O5;   InChI=1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13);   InChIKey=PCMORTLOPMLEFB-UHFFFAOYSA-N;   SMILES=COc1cc(C=CC(O)=O)cc(OC)c1O
 xref: CAS:530-59-6;   DrugBank:DB08587;   KEGG:C00482
 xref_mesh: MESH:C073734
 xref: Wikipedia:Sinapinic_acid


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sinapic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein] CTD PMID:33720507 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] CTD PMID:33720507 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate affects the localization of CASP3 protein]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of CASP3 protein] CTD PMID:33720507 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of CAT protein] CTD PMID:33720507 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO sinapinic acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in increased expression of GPT protein] CTD PMID:33720507 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein] CTD PMID:33720507 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
sinapinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
CTD PMID:18841975 PMID:33720507 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mb myoglobin multiple interactions EXP sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein] CTD PMID:32627257 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP sinapinic acid inhibits the reaction [Methotrexate results in increased expression of MPO protein] CTD PMID:33720507 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:18841975 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18841975 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18841975 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP sinapinic acid inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:32627257 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO sinapinic acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:18841975 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18841975 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
sinapinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]
CTD PMID:18841975 PMID:33720507 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        polyatomic entity 19732
          heteroatomic molecular entity 19673
            hydroxides 19175
              organic hydroxy compound 18668
                phenols 18146
                  sinapic acid 18
                    cis-sinapic acid 0
                    trans-sinapic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          alpha,beta-unsaturated monocarboxylic acid 12218
                                            cinnamic acids 2420
                                              hydroxycinnamic acid 1270
                                                monohydroxycinnamic acid 933
                                                  sinapic acid 18
                                                    cis-sinapic acid 0
                                                    trans-sinapic acid + 0
paths to the root