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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Obacunone
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Accession:CHEBI:7713 term browser browse the term
Definition:A limonoid that has formula C26H30O7.
Synonyms:related_synonym: Formula=C26H30O7;   InChI=1S/C26H30O7/c1-22(2)16-12-17(27)25(5)15(23(16,3)9-7-18(28)32-22)6-10-24(4)19(14-8-11-30-13-14)31-21(29)20-26(24,25)33-20/h7-9,11,13,15-16,19-20H,6,10,12H2,1-5H3/t15-,16+,19+,20-,23-,24+,25+,26-/m1/s1;   InChIKey=MAYJEFRPIKEYBL-OASIGRBWSA-N;   SMILES=C[C@@]12CC[C@@H]3[C@@]4(C)C=CC(=O)OC(C)(C)[C@@H]4CC(=O)[C@@]3(C)[C@]11O[C@@H]1C(=O)O[C@H]2c1ccoc1
 xref: CAS:751-03-1;   KEGG:C08775;   KNApSAcK:C00003723
 xref_mesh: MESH:C067207


show annotations for term's descendants           Sort by:
Obacunone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions		 ISO obacunone results in decreased expression of AKT1 protein modified form
obacunone results in decreased expression of and results in decreased phosphorylation of AKT1 protein		 CTD PMID:25592883 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor affects expression ISO obacunone affects the expression of AR protein CTD PMID:25592883 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO obacunone results in increased expression of BAD protein CTD PMID:25592883 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO obacunone results in increased expression of BAX mRNA; obacunone results in increased expression of BAX protein CTD PMID:21333732 PMID:25592883 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO obacunone results in decreased expression of BCL2 mRNA; obacunone results in decreased expression of BCL2 protein CTD PMID:21333732 PMID:25592883 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
decreases expression
multiple interactions		 ISO obacunone results in increased activity of CASP3 protein
obacunone results in decreased expression of CASP3 protein
obacunone results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:21333732 PMID:25592883 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression
increases cleavage		 ISO obacunone results in decreased expression of CASP8 protein
obacunone results in increased cleavage of CASP8 protein		 CTD PMID:21333732 PMID:25592883 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO obacunone results in increased activity of CASP9 protein
obacunone results in increased cleavage of CASP9 protein		 CTD PMID:21333732 PMID:25592883 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO obacunone results in increased expression of CDKN1A protein CTD PMID:25592883 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Il6 interleukin 6 decreases expression ISO obacunone results in decreased expression of IL6 protein CTD PMID:25592883 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression ISO obacunone results in decreased expression of KLK3 protein CTD PMID:25592883 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO obacunone results in decreased expression of PTGS2 protein CTD PMID:21333732 PMID:25592883 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO obacunone results in decreased expression of RELA protein CTD PMID:21333732 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO obacunone results in increased expression of TP53 protein CTD PMID:21333732 PMID:25592883 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          carbon atom 19734
            organic molecular entity 19705
              isoprenoid 14026
                terpenoid 13711
                  triterpenoid 873
                    limonoid 149
                      Obacunone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            organic hydride 18656
                              organic fundamental parent 18656
                                hydrocarbon 18396
                                  terpene 14014
                                    triterpene 875
                                      triterpenoid 873
                                        limonoid 149
                                          Obacunone 14
paths to the root