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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor
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Accession:CHEBI:77117 term browser browse the term
Definition:An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any such enzyme acting on the C-N bond of nitriles (EC 3.5.5.*).
Synonyms:related_synonym: EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitors;   EC 3.5.5.* inhibitor;   EC 3.5.5.* inhibitors;   inhibitor of hydrolases acting on C-N bonds in nitriles;   inhibitors of hydrolases acting on C-N bonds in nitriles


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benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b15 aldo-keto reductase family 1 member B15 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of benzaldehyde CTD PMID:18845131 NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases oxidation
increases metabolic processing 		EXP
ISO 		ALDH1A1 protein results in increased oxidation of benzaldehyde
ALDH1A1 protein results in increased metabolism of benzaldehyde 		CTD PMID:10998257 PMID:21256123 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases oxidation EXP ALDH1A7 protein results in increased oxidation of benzaldehyde CTD PMID:10998257 NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing
multiple interactions 		ISO ALDH2 protein results in increased metabolism of benzaldehyde
benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein] 		CTD PMID:10609638 PMID:11744614 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions
increases oxidation
increases metabolic processing 		ISO [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
ALDH3A1 protein results in increased metabolism of benzaldehyde 		CTD PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding ISO benzaldehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr 1:210,574,545...210,605,188
Ensembl chr 1:210,573,661...210,610,538 		JBrowse link
G Ar androgen receptor multiple interactions EXP benzaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Or8a1b olfactory receptor family 8 subfamily A member 1B multiple interactions ISO benzaldehyde binds to and results in increased activity of OR8A1 protein CTD PMID:11943806 NCBI chr 8:45,623,650...45,624,579
Ensembl chr 8:45,623,650...45,624,579 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases activity
multiple interactions 		ISO benzaldehyde results in increased activity of SLC2A1 protein
[benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein 		CTD PMID:20955755 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
benzylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO benzylamine binds to and results in increased activity of AHR protein CTD PMID:11790108 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          enzyme inhibitor 19247
            EC 3.* (hydrolase) inhibitor 18773
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 18596
                EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor 10
                  EC 3.5.5.1 (nitrilase) inhibitor + 10
paths to the root