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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor
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Accession:CHEBI:77117 term browser browse the term
Definition:An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any such enzyme acting on the C-N bond of nitriles (EC 3.5.5.*).
Synonyms:related_synonym: EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitors;   EC 3.5.5.* inhibitor;   EC 3.5.5.* inhibitors;   inhibitor of hydrolases acting on C-N bonds in nitriles;   inhibitors of hydrolases acting on C-N bonds in nitriles


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benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of benzaldehyde CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases oxidation
increases metabolic processing		 EXP
ISO		 ALDH1A1 protein results in increased oxidation of benzaldehyde
ALDH1A1 protein results in increased metabolism of benzaldehyde		 CTD PMID:10998257 PMID:21256123 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing
multiple interactions		 ISO ALDH2 protein results in increased metabolism of benzaldehyde
benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]		 CTD PMID:10609638 PMID:11744614 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions
increases oxidation
increases metabolic processing		 ISO [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
ALDH3A1 protein results in increased metabolism of benzaldehyde		 CTD PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding ISO benzaldehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921 		JBrowse link
G Ar androgen receptor multiple interactions EXP benzaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases activity
multiple interactions		 ISO benzaldehyde results in increased activity of SLC2A1 protein
[benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein		 CTD PMID:20955755 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
benzylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO benzylamine binds to and results in increased activity of AHR protein CTD PMID:11790108 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        biochemical role 19380
          enzyme inhibitor 18391
            EC 3.* (hydrolase) inhibitor 17932
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 17810
                EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor 8
                  EC 3.5.5.1 (nitrilase) inhibitor + 8
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