Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor
go back to main search page
Accession:CHEBI:77106 term browser browse the term
Definition:An EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor that interferes with the action of quinol--cytochrome-c reductase (EC 1.10.2.2).
Synonyms:related_synonym: EC 1.10.2.2 inhibitor;   EC 1.10.2.2 inhibitors;   inhibitor of quinol--cytochrome-c reductase (EC 1.10.2.2);   inhibitors of quinol--cytochrome-c reductase (EC 1.10.2.2);   quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors
 xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase



show annotations for term's descendants           Sort by:
atovaquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO Atovaquone results in increased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity
affects binding
ISO
EXP
Atovaquone results in decreased activity of DHODH protein
Atovaquone binds to Dhodh protein
CTD
RGD
PMID:10658902 PMID:15044733 RGD:2316233 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Atovaquone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        biochemical role 19517
          enzyme inhibitor 18726
            EC 1.* (oxidoreductase) inhibitor 17527
              EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor 4582
                EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor 3
                  EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor 3
                    atovaquone 3
paths to the root