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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenbendazole
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Accession:CHEBI:77092 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
Synonyms:exact_synonym: methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate
 related_synonym: 2-(methoxycarbonylamino)-5-(phenylthio)benzimidazole;   5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester;   Formula=C15H13N3O2S;   Hoe 881v;   InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19);   InChIKey=HDDSHPAODJUKPD-UHFFFAOYSA-N;   Panacur;   SMILES=COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1;   Safe-quard;   [5-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester;   fenbendazol;   fenbendazolum;   methyl 5-(phenylthio)-2-benzimidazolecarbamate;   methyl [5-(phenylthio)-1H-benzimidazol-2-yl]carbamate
 xref: CAS:43210-67-9;   Drug_Central:4536;   HMDB:HMDB0029745;   KEGG:D04140;   LINCS:LSM-3134
 xref_mesh: MESH:D005273
 xref: PMID:22048645;   PMID:23488766;   PMID:23959307;   PMID:24183965;   Patent:DE2164690;   Patent:US3954791;   Reaxys:759077;   VSDB:1758;   Wikipedia:Fenbendazole



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fenbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Fenbendazole analog results in decreased expression of ARAF protein CTD PMID:35569513 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Aurkb aurora kinase B increases expression EXP Fenbendazole results in increased expression of AURKB protein CTD PMID:23411599 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Fenbendazole analog results in increased expression of BAX protein; Fenbendazole results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [Fenbendazole analog results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenbendazole results in increased expression of BAX protein]; SB 203580 inhibits the reaction [Fenbendazole analog results in increased expression of BAX protein]; SB 203580 inhibits the reaction [Fenbendazole results in increased expression of BAX protein]
CTD PMID:35569513 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Fenbendazole analog results in decreased expression of BCL2 protein; Fenbendazole results in decreased expression of BCL2 protein CTD PMID:35569513 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO Fenbendazole analog results in increased expression of CASP3 mRNA
Fenbendazole analog results in increased cleavage of CASP3 protein; Fenbendazole results in increased cleavage of CASP3 protein
CTD PMID:35569513 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression ISO Fenbendazole analog results in increased expression of CASP8 mRNA; Fenbendazole results in increased expression of CASP8 mRNA CTD PMID:35569513 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
ISO Fenbendazole analog results in increased cleavage of CASP9 protein; Fenbendazole results in increased cleavage of CASP9 protein
Fenbendazole analog results in increased expression of CASP9 mRNA; Fenbendazole results in increased expression of CASP9 mRNA
CTD PMID:35569513 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbx5 chromobox 5 increases expression EXP Fenbendazole results in increased expression of CBX5 protein CTD PMID:23411599 NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Fenbendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Fenbendazole results in increased expression of CCND1 mRNA CTD PMID:23411599 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne2 cyclin E2 increases expression EXP Fenbendazole results in increased expression of CCNE2 mRNA CTD PMID:23411599 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Fenbendazole analog results in increased expression of CDH1 protein; Fenbendazole results in increased expression of CDH1 protein CTD PMID:35569513 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 affects expression ISO Fenbendazole affects the expression of CDH2 protein; Fenbendazole analog affects the expression of CDH2 protein CTD PMID:35569513 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Fenbendazole results in increased expression of CDK1 mRNA; Fenbendazole results in increased expression of CDK1 protein CTD PMID:23411599 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Fenbendazole results in increased expression of CDKN1A mRNA; Fenbendazole results in increased expression of CDKN1A protein CTD PMID:23411599 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases methylation
increases expression
decreases expression
EXP Fenbendazole results in increased methylation of CDKN2A gene
Fenbendazole results in increased expression of CDKN2A protein
Fenbendazole results in decreased expression of CDKN2A protein
CTD PMID:22659510 PMID:23411599 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression EXP Fenbendazole results in increased expression of CDKN2B mRNA CTD PMID:23411599 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdr2 cerebellar degeneration-related protein 2 increases expression EXP Fenbendazole results in increased expression of CDR2 mRNA CTD PMID:23411599 NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Fenbendazole results in decreased activity of CYP1A2 protein CTD PMID:22048645 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Fenbendazole analog results in increased expression of DNM1L mRNA; Fenbendazole results in increased expression of DNM1L mRNA CTD PMID:35569513 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Fenbendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Fenbendazole analog results in increased expression of H2AX protein; Fenbendazole results in increased expression of H2AX protein CTD PMID:35569513 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Fenbendazole results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Ifng interferon gamma increases expression ISO Fenbendazole analog results in increased expression of IFNG mRNA; Fenbendazole results in increased expression of IFNG mRNA CTD PMID:35569513 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 increases expression ISO Fenbendazole analog results in increased expression of IL6 mRNA; Fenbendazole results in increased expression of IL6 mRNA CTD PMID:35569513 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Fenbendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Incenp inner centromere protein increases expression EXP Fenbendazole results in increased expression of INCENP protein CTD PMID:23411599 NCBI chr 1:206,520,655...206,550,575
Ensembl chr 1:206,523,380...206,553,265
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Fenbendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mdh2 malate dehydrogenase 2 increases expression ISO Fenbendazole analog results in increased expression of MDH2 mRNA; Fenbendazole results in increased expression of MDH2 mRNA CTD PMID:35569513 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mfn2 mitofusin 2 increases expression ISO Fenbendazole results in increased expression of MFN2 mRNA CTD PMID:35569513 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Fenbendazole results in increased expression of MKI67 protein CTD PMID:23411599 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Fenbendazole analog results in decreased expression of MMP2 mRNA; Fenbendazole analog results in decreased expression of MMP2 protein CTD PMID:35569513 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects expression
decreases expression
ISO Fenbendazole affects the expression of MMP9 protein; Fenbendazole analog affects the expression of MMP9 protein
Fenbendazole analog results in decreased expression of MMP9 mRNA; Fenbendazole results in decreased expression of MMP9 mRNA
CTD PMID:35569513 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase increases expression ISO Fenbendazole results in increased expression of OPA1 mRNA CTD PMID:35569513 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Fenbendazole results in decreased expression of PTGS2 mRNA CTD PMID:35569513 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
ISO Fenbendazole analog results in increased phosphorylation of RELA protein; Fenbendazole results in increased phosphorylation of RELA protein
Acetylcysteine inhibits the reaction [Fenbendazole analog results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Fenbendazole results in increased phosphorylation of RELA protein]
CTD PMID:35569513 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 increases expression ISO Fenbendazole analog results in increased expression of SIRT1 mRNA; Fenbendazole results in increased expression of SIRT1 mRNA CTD PMID:35569513 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Fenbendazole analog results in decreased expression of SLC2A1 mRNA; Fenbendazole results in decreased expression of SLC2A1 mRNA CTD PMID:35569513 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression ISO Fenbendazole analog results in decreased expression of SLC2A4 mRNA; Fenbendazole results in decreased expression of SLC2A4 mRNA CTD PMID:35569513 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha increases expression ISO Fenbendazole analog results in increased expression of SUCLG1 mRNA; Fenbendazole results in increased expression of SUCLG1 mRNA CTD PMID:35569513 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Tmem70 transmembrane protein 70 multiple interactions EXP [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of TMEM70 protein CTD PMID:27914986 NCBI chr 5:2,637,102...2,654,729
Ensembl chr 5:2,637,102...2,654,729
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
multiple interactions
ISO Fenbendazole results in increased secretion of TNF protein
Fenbendazole analog results in increased expression of TNF mRNA
U 0126 inhibits the reaction [Fenbendazole results in increased secretion of TNF protein]
CTD PMID:20848085 PMID:35569513 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression EXP
ISO
Fenbendazole results in increased expression of TP53 protein
Fenbendazole analog results in increased expression of TP53 protein; Fenbendazole results in increased expression of TP53 protein
CTD PMID:23411599 PMID:35569513 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 multiple interactions EXP [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of UBE2E2 protein CTD PMID:27914986 NCBI chr15:6,980,195...7,257,912
Ensembl chr15:6,980,474...7,257,532
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Fenbendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases expression EXP Fenbendazole results in decreased expression of WEE1 protein modified form CTD PMID:23411599 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
oxfendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
decreases activity
multiple interactions
ISO ABCG2 protein affects the transport of oxfendazole
oxfendazole results in decreased activity of ABCG2 protein
oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]
CTD PMID:15703302 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA] CTD PMID:18754104 PMID:20033131 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Casp3 caspase 3 increases cleavage EXP oxfendazole results in increased cleavage of CASP3 protein CTD PMID:26558467 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP oxfendazole results in increased expression of CDKN1A protein CTD PMID:26558467 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 affects expression EXP oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 protein; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA] CTD PMID:18754104 PMID:20033131 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA CTD PMID:18754104 PMID:20033131 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GPX2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:18754104 PMID:20033131 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:18754104 PMID:20033131 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GSTM1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTM1 mRNA CTD PMID:18754104 PMID:20033131 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression EXP oxfendazole results in decreased expression of MAD2L1 mRNA CTD PMID:26558467 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases phosphorylation
increases expression
EXP oxfendazole results in decreased phosphorylation of MDM2 protein
oxfendazole results in increased expression of MDM2 mRNA
CTD PMID:26558467 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:18754104 PMID:20033131 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression EXP oxfendazole results in decreased expression of MKI67 protein CTD PMID:26558467 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of NQO1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:18754104 PMID:20033131 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP oxfendazole results in decreased expression of TOP2A protein CTD PMID:26558467 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP oxfendazole results in decreased expression of TP53 mRNA CTD PMID:26558467 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19659
    role 19634
      application 19465
        pesticide 17298
          nematicide 6476
            antinematodal drug 4690
              fenbendazole 60
                hydroxyfenbendazole 0
                oxfendazole 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic ester 15889
                                        carbamate ester 7468
                                          fenbendazole 60
                                            hydroxyfenbendazole 0
                                            oxfendazole 19
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