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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:closantel
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Accession:CHEBI:77053 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.
Synonyms:exact_synonym: rac-N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
 related_synonym: 5'-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2',4'-salicyloxylidide;   Flukiver;   R 31,520;   R 31520;   Seponver;   closantelum
 xref: CAS:57808-65-8;   KEGG:D03567
 xref_mesh: MESH:C023342
 xref: PMID:21247019;   PMID:22916226;   PMID:23992251;   PMID:3330516;   PMID:4054009;   PMID:7119989;   PMID:7571353;   PMID:9138034;   Patent:BE839481;   Patent:US4005218;   Reaxys:6249214



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closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1A protein results in decreased susceptibility to closantel
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
CTD PMID:20513441 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Slc25a31 solute carrier family 25 member 31 decreases activity ISO closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795
JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases activity ISO closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Slc25a6 solute carrier family 25 member 6 decreases activity ISO closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr18:68,571,229...68,572,474
Ensembl chr18:68,571,300...68,572,199
JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      chemical substance 13303
        mixture 12454
          racemate 10537
            closantel 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                monocarboxylic acid amide 15515
                                                  N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                                                    (R)-closantel 8
                                                      closantel 8
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