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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bromhexine
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Accession:CHEBI:77032 term browser browse the term
Definition:A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Synonyms:exact_synonym: 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
 related_synonym: 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine;   Fluibron;   Formula=C14H20Br2N2;   InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3;   InChIKey=OJGDCBLYJGHCIH-UHFFFAOYSA-N;   N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine;   SMILES=CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1;   bromhexina;   bromhexinum
 xref: Beilstein:2216008;   CAS:3572-43-8;   Drug_Central:402;   KEGG:D07542;   LINCS:LSM-3048
 xref_mesh: MESH:D001964
 xref: PMID:20031363;   PMID:22027391;   PMID:23781460;   PMID:4065592;   PMID:7027431;   PMID:7027873;   PMID:778563;   Patent:BE625022;   Wikipedia:Bromhexine
 cyclic_relationship: is_conjugate_base_of CHEBI:77040


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bromhexine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Bromhexine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bromhexine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      application 19465
        pharmaceutical 19355
          drug 19355
            mucolytic 909
              bromhexine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        aromatic amine 14884
                                          anilines 13948
                                            substituted aniline 13624
                                              bromhexine 2
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