methylseleninic acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	methylseleninic acid	go back to main search page
Accession:	CHEBI:77012	browse the term
Definition:	An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Synonyms:	exact_synonym:	methaneseleninic acid
	related_synonym:	Formula=CH4O2Se; InChI=1S/CH4O2Se/c1-4(2)3/h1H3,(H,2,3); InChIKey=UEQANLFPOFICBH-UHFFFAOYSA-N; Methylseleninate; SMILES=C[Se](O)=O
	xref:	CAS:28274-57-9; KEGG:C18902
	xref_mesh:	MESH:C008493
	xref:	PMID:21500193; PMID:21519842; PMID:21910718; PMID:22095442; PMID:22128327; PMID:22179721; PMID:22348099; PMID:22640261; PMID:22711297; PMID:22975630; PMID:23470450; PMID:23613334; PMID:23995784; PMID:24001829; PMID:24447148; PMID:24515947; Reaxys:1734752; Wikipedia:Methaneseleninic_Acid

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Genes (413)

methylseleninic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4 (PEL blood group)

multiple interactions
affects expression
decreases expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of ABCC4 mRNA]
methylselenic acid affects the expression of ABCC4 mRNA

PMID:14617803 PMID:16020662 PMID:18548127

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

acid phosphatase 3

affects expression

methylselenic acid affects the expression of ACP3 mRNA

NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302

G

acyl-CoA synthetase long chain family member 3

affects expression
decreases expression

methylselenic acid affects the expression of ACSL3 mRNA
methylselenic acid results in decreased expression of ACSL3 mRNA

PMID:14617803 PMID:18548127

NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639

G

actin alpha 2, smooth muscle

increases expression

methylselenic acid results in increased expression of ACTA2 mRNA

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

actin gamma 2, smooth muscle

increases expression

methylselenic acid results in increased expression of ACTG2 mRNA

NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865

G

ADAM metallopeptidase domain 22

increases expression

methylselenic acid results in increased expression of ADAM22 mRNA

NCBI chr 7:87,934,251...88,202,889
Ensembl chr 7:87,934,143...88,202,889

G

adducin 3

increases expression

methylselenic acid results in increased expression of ADD3 mRNA

NCBI chr10:109,996,373...110,135,565
Ensembl chr10:109,996,368...110,135,565

G

adhesion G protein-coupled receptor L3

increases expression

methylselenic acid results in increased expression of ADGRL3 mRNA

NCBI chr 4:61,200,326...62,078,335
Ensembl chr 4:61,200,326...62,078,335

G

aryl hydrocarbon receptor

increases expression

methylselenic acid results in increased expression of AHR mRNA

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

A-kinase anchoring protein 12

increases expression

methylselenic acid results in increased expression of AKAP12 mRNA

NCBI chr 6:151,239,967...151,358,559
Ensembl chr 6:151,239,967...151,358,559

G

aldo-keto reductase family 1 member B

increases expression

methylselenic acid results in increased expression of AKR1B1 mRNA

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

AKT serine/threonine kinase 1

multiple interactions
decreases response to substance
decreases phosphorylation

[methylselenic acid results in decreased phosphorylation of AKT1 protein] which results in increased susceptibility to Doxorubicin; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
AKT1 protein results in decreased susceptibility to methylselenic acid

PMID:15845651 PMID:17339365

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

AKT serine/threonine kinase 2

decreases expression

methylselenic acid results in decreased expression of AKT2 mRNA

NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536

G

aminolevulinate dehydratase

increases expression

methylselenic acid results in increased expression of ALAD mRNA

NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290

G

ALG3 alpha-1,3- mannosyltransferase

decreases expression

methylselenic acid results in decreased expression of ALG3 mRNA

NCBI chr 3:184,242,301...184,249,525
Ensembl chr 3:184,242,301...184,249,548

G

ALG8 alpha-1,3-glucosyltransferase

decreases expression

methylselenic acid results in decreased expression of ALG8 mRNA

NCBI chr11:78,100,946...78,139,626
Ensembl chr11:78,095,244...78,139,660

G

aminomethyltransferase

increases expression

methylselenic acid results in increased expression of AMT mRNA

NCBI chr 3:49,416,778...49,422,473
Ensembl chr 3:49,416,778...49,422,685

G

ankyrin 2

increases expression

methylselenic acid results in increased expression of ANK2 mRNA

NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221

G

ankyrin 3

decreases expression

methylselenic acid results in decreased expression of ANK3 mRNA

NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490

G

apolipoprotein D

affects expression

methylselenic acid affects the expression of APOD mRNA

NCBI chr 3:195,568,705...195,583,940
Ensembl chr 3:195,568,705...195,584,033

G

androgen receptor

affects response to substance
increases degradation
decreases expression
decreases activity
multiple interactions

AR protein affects the susceptibility to methylselenic acid
methylselenic acid results in increased degradation of AR mRNA; methylselenic acid results in increased degradation of AR protein
methylselenic acid results in decreased expression of AR mRNA; methylselenic acid results in decreased expression of AR protein
methylselenic acid results in decreased activity of AR protein
AR protein inhibits the reaction [methylselenic acid results in decreased expression of ABCC4 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of DHCR24 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of GUCY1A1 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK2 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK3 mRNA]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 promoter]]; Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein]

PMID:14617803 PMID:15141018 PMID:16020662 PMID:16648561 PMID:16928829

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

methylselenic acid results in increased expression of ARHGEF2 mRNA

NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070

G

ADP ribosylation factor like GTPase 4A

increases expression

methylselenic acid results in increased expression of ARL4A mRNA

NCBI chr 7:12,686,903...12,690,958
Ensembl chr 7:12,686,856...12,690,958

G

activating transcription factor 2

multiple interactions

methylselenic acid results in increased phosphorylation of and results in increased activity of ATF2 protein

NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382

G

activating transcription factor 3

affects expression

methylselenic acid affects the expression of ATF3 mRNA

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

activating transcription factor 5

decreases expression

methylselenic acid results in decreased expression of ATF5 mRNA

PMID:12517777 PMID:18548127

NCBI chr19:49,928,906...49,933,935
Ensembl chr19:49,928,702...49,933,935

G

activating transcription factor 6

multiple interactions

methylselenic acid results in increased cleavage of and results in increased activity of ATF6 protein

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

methylselenic acid results in increased expression of ATP2A2 mRNA

NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093

G

ATPase plasma membrane Ca2+ transporting 4

increases expression

methylselenic acid results in increased expression of ATP2B4 mRNA

NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,832...203,744,081

G

aurora kinase A

affects expression
decreases expression

methylselenic acid affects the expression of AURKA mRNA
methylselenic acid results in decreased expression of AURKA mRNA

PMID:12517777 PMID:14617803

NCBI chr20:56,369,390...56,392,215
Ensembl chr20:56,369,389...56,392,337

G

beta-1,4-galactosyltransferase 1

affects expression

methylselenic acid affects the expression of B4GALT1 mRNA

NCBI chr 9:33,104,077...33,185,089
Ensembl chr 9:33,104,082...33,167,356

G

BTB domain and CNC homolog 1

increases expression

methylselenic acid results in increased expression of BACH1 mRNA

NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751

G

BCL2 associated X, apoptosis regulator

affects expression

methylselenic acid affects the expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 binding component 3

increases expression

methylselenic acid results in increased expression of BBC3 mRNA

NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766

G

BCL2 apoptosis regulator

affects expression

methylselenic acid affects the expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 related protein A1

increases expression

methylselenic acid results in increased expression of BCL2A1 mRNA

NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196

G

BCL2 like 11

multiple interactions
increases cleavage
increases expression

BCL2L11 protein affects the susceptibility to [Doxorubicin co-treated with methylselenic acid]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of BCL2L11 protein]
methylselenic acid results in increased expression of BCL2L11 mRNA; methylselenic acid results in increased expression of BCL2L11 protein

PMID:17339365 PMID:18790785 PMID:28161410

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

baculoviral IAP repeat containing 2

affects expression

methylselenic acid affects the expression of BIRC2 mRNA

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

affects expression

methylselenic acid affects the expression of BIRC3 mRNA

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

baculoviral IAP repeat containing 5

multiple interactions
decreases expression

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of BIRC5 protein; methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]
methylselenic acid results in decreased expression of BIRC5 mRNA; methylselenic acid results in decreased expression of BIRC5 protein

PMID:12517777 PMID:17876054 PMID:18444175 PMID:18567002

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

bone morphogenetic protein 4

increases expression

methylselenic acid results in increased expression of BMP4 mRNA

NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761

G

BRCA2 DNA repair associated

increases expression

methylselenic acid results in increased expression of BRCA2 mRNA

NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268

G

BTG anti-proliferation factor 3

increases expression

methylselenic acid results in increased expression of BTG3 mRNA

NCBI chr21:17,593,653...17,612,901
Ensembl chr21:17,593,653...17,612,945

G

BUB1 mitotic checkpoint serine/threonine kinase B

affects expression

methylselenic acid affects the expression of BUB1B mRNA

NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123

G

complement C1q binding protein

decreases expression

methylselenic acid results in decreased expression of C1QBP mRNA

NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830

G

cell adhesion molecule 1

affects expression

methylselenic acid affects the expression of CADM1 mRNA

NCBI chr11:115,169,236...115,504,415
Ensembl chr11:115,169,218...115,504,957

G

calmodulin 1

increases expression

methylselenic acid results in increased expression of CALM1 mRNA

NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268

G

calcium/calmodulin dependent protein kinase II gamma

increases expression

methylselenic acid results in increased expression of CAMK2G mRNA

NCBI chr10:73,812,501...73,874,555
Ensembl chr10:73,812,501...73,874,591

G

calcium/calmodulin dependent protein kinase IV

increases expression

methylselenic acid results in increased expression of CAMK4 mRNA

NCBI chr 5:111,223,583...111,494,886
Ensembl chr 5:111,223,653...111,494,886

G

capping actin protein of muscle Z-line subunit alpha 1

decreases expression

methylselenic acid results in decreased expression of CAPZA1 mRNA

NCBI chr 1:112,619,832...112,671,616
Ensembl chr 1:112,619,805...112,671,616

G

caspase 12 (gene/pseudogene)

multiple interactions
increases cleavage

HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP12 protein]

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

G

caspase 3

multiple interactions
increases cleavage

methylselenic acid results in increased cleavage of and results in increased activity of CASP3 protein
methylselenic acid results in increased cleavage of CASP3 protein

PMID:19276161 PMID:28161410

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 4

increases cleavage

methylselenic acid results in increased cleavage of CASP4 protein

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

G

caspase 7

increases cleavage
multiple interactions

methylselenic acid results in increased cleavage of CASP7 protein
Acetylcysteine inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; methylselenic acid inhibits the reaction [CASP7 protein binds to HSPA5 protein]; Sodium Selenite inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of CASP7 protein]

PMID:16204082 PMID:18790785 PMID:28161410

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 8

multiple interactions
increases cleavage

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP8 protein; [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 protein
[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; methylselenic acid results in increased cleavage of CASP8 protein

PMID:18444175 PMID:18790785

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases cleavage
increases expression

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP9 protein; [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein]; methylselenic acid results in increased cleavage of and results in increased activity of CASP9 protein
[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; methylselenic acid results in increased cleavage of CASP9 protein
methylselenic acid results in increased expression of CASP9 mRNA

PMID:12517777 PMID:17339365 PMID:18444175 PMID:18790785 PMID:28161410

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

calpastatin

increases expression

methylselenic acid results in increased expression of CAST mRNA

NCBI chr 5:95,961,429...96,774,683
Ensembl chr 5:96,525,267...96,779,595
Ensembl chr 5:96,525,267...96,779,595

G

chromobox 7

increases expression

methylselenic acid results in increased expression of CBX7 mRNA

NCBI chr22:39,130,772...39,152,680
Ensembl chr22:39,120,167...39,152,680

G

cholecystokinin

increases expression

methylselenic acid results in increased expression of CCK mRNA

NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185

G

cyclin A2

decreases expression

methylselenic acid results in decreased expression of CCNA2 mRNA

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

decreases expression

methylselenic acid results in decreased expression of CCNB1 mRNA; methylselenic acid results in decreased expression of CCNB1 protein

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

affects expression
decreases expression
multiple interactions

methylselenic acid affects the expression of CCND1 mRNA
methylselenic acid affects the expression of CCND1 protein
methylselenic acid results in decreased expression of CCND1 mRNA
[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CCND1 protein; KLF4 protein affects the reaction [methylselenic acid results in decreased expression of CCND1 mRNA]; methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]

PMID:11830524 PMID:12017302 PMID:17847021 PMID:18314491 PMID:18444175

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin E2

decreases expression

methylselenic acid results in decreased expression of CCNE2 mRNA

NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678

G

CD14 molecule

decreases expression

methylselenic acid results in decreased expression of CD14 mRNA

NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700

G

CD44 molecule (IN blood group)

decreases expression

methylselenic acid results in decreased expression of CD44 mRNA

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

cell division cycle 14B

affects expression

methylselenic acid affects the expression of CDC14B mRNA

NCBI chr 9:96,490,939...96,619,843
Ensembl chr 9:96,490,241...96,619,843

G

cell division cycle 20

affects expression

methylselenic acid affects the expression of CDC20 mRNA

NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203

G

cell division cycle 25A

affects expression
decreases expression

methylselenic acid affects the expression of CDC25A mRNA
methylselenic acid results in decreased expression of CDC25A mRNA; methylselenic acid results in decreased expression of CDC25A protein

PMID:11830524 PMID:14617803

NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417

G

cell division cycle 25C

decreases expression

methylselenic acid results in decreased expression of CDC25C mRNA

NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355

G

cell division cycle 42

decreases expression

methylselenic acid results in decreased expression of CDC42 mRNA

NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360

G

CDC42 effector protein 3

increases expression

methylselenic acid results in increased expression of CDC42EP3 mRNA

NCBI chr 2:37,641,944...37,672,949
Ensembl chr 2:37,641,882...37,738,468

G

cell division cycle 6

decreases expression
affects expression

methylselenic acid results in decreased expression of CDC6 mRNA
methylselenic acid affects the expression of CDC6 mRNA

PMID:11830524 PMID:14617803

NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657

G

cadherin 15

increases expression

methylselenic acid results in increased expression of CDH15 mRNA

NCBI chr16:89,171,748...89,195,492
Ensembl chr16:89,171,748...89,195,492

G

cadherin 7

increases expression

methylselenic acid results in increased expression of CDH7 mRNA

NCBI chr18:65,750,252...65,890,337
Ensembl chr18:65,750,252...65,890,337

G

cyclin dependent kinase 1

multiple interactions
decreases expression

HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK1 protein]
methylselenic acid results in decreased expression of CDK1 mRNA; methylselenic acid results in decreased expression of CDK1 protein

PMID:11830524 PMID:12517777 PMID:16205645

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 10

decreases expression

methylselenic acid results in decreased expression of CDK10 mRNA

NCBI chr16:89,686,689...89,696,354
Ensembl chr16:89,680,737...89,696,354

G

cyclin dependent kinase 16

decreases expression

methylselenic acid results in decreased expression of CDK16 mRNA

NCBI chr X:47,218,303...47,229,997
Ensembl chr X:47,217,860...47,229,997

G

cyclin dependent kinase 18

increases expression

methylselenic acid results in increased expression of CDK18 mRNA

NCBI chr 1:205,504,669...205,532,790
Ensembl chr 1:205,504,596...205,532,793

G

cyclin dependent kinase 2

multiple interactions
decreases expression

HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK2 protein]; methylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]
methylselenic acid results in decreased expression of CDK2 mRNA; methylselenic acid results in decreased expression of CDK2 protein

PMID:12517777 PMID:16205645 PMID:17847021

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase 4

multiple interactions
decreases expression

methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]
methylselenic acid results in decreased expression of CDK4 mRNA

PMID:11830524 PMID:12517777 PMID:17847021 PMID:18548127

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase 5

increases expression

methylselenic acid results in increased expression of CDK5 mRNA

NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897

G

cyclin dependent kinase 6

multiple interactions

methylselenic acid promotes the reaction [CDKN2A protein binds to CDK6 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK6 protein]

NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573

G

cyclin dependent kinase like 1

decreases expression

methylselenic acid results in decreased expression of CDKL1 mRNA

NCBI chr14:50,326,265...50,397,298
Ensembl chr14:50,326,265...50,416,461

G

cyclin dependent kinase inhibitor 1A

multiple interactions
affects expression
increases expression

DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; HSPA5 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; methylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in increased expression of and results in decreased degradation of CDKN1A protein
methylselenic acid affects the expression of CDKN1A protein
methylselenic acid results in increased expression of CDKN1A mRNA; methylselenic acid results in increased expression of CDKN1A protein
methylselenic acid affects the expression of CDKN1A mRNA

PMID:12017302 PMID:12517777 PMID:14617803 PMID:16205645 PMID:17847021 More...

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

cyclin dependent kinase inhibitor 1B

multiple interactions
affects expression
increases expression

KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1B mRNA]; methylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]
methylselenic acid affects the expression of CDKN1B protein
methylselenic acid results in increased expression of CDKN1B mRNA; methylselenic acid results in increased expression of CDKN1B protein

PMID:12017302 PMID:17847021 PMID:18314491

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cyclin dependent kinase inhibitor 1C

increases expression
affects expression

methylselenic acid results in increased expression of CDKN1C mRNA
methylselenic acid affects the expression of CDKN1C mRNA

PMID:14617803 PMID:18548127

NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775

G

cyclin dependent kinase inhibitor 2A

multiple interactions
increases expression

methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid promotes the reaction [CDKN2A protein binds to CDK6 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK6 protein]
methylselenic acid results in increased expression of CDKN2A protein

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

cyclin dependent kinase inhibitor 2D

increases expression
affects expression

methylselenic acid results in increased expression of CDKN2D mRNA
methylselenic acid affects the expression of CDKN2D mRNA

PMID:12517777 PMID:14617803

NCBI chr19:10,566,460...10,568,979
Ensembl chr19:10,566,460...10,569,059

G

centromere protein A

affects expression

methylselenic acid affects the expression of CENPA mRNA

NCBI chr 2:26,786,056...26,794,589
Ensembl chr 2:26,764,289...26,801,067

G

centromere protein F

decreases expression

methylselenic acid results in decreased expression of CENPF mRNA

NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,185...214,664,574

G

CASP8 and FADD like apoptosis regulator

multiple interactions

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CFLAR protein

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

chromatin assembly factor 1 subunit A

decreases expression

methylselenic acid results in decreased expression of CHAF1A mRNA

NCBI chr19:4,402,640...4,450,830
Ensembl chr19:4,402,640...4,445,018

G

checkpoint kinase 2

increases expression

methylselenic acid results in increased expression of CHEK2 mRNA

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

clusterin

affects expression

methylselenic acid affects the expression of CLU mRNA

NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700

G

canopy FGF signaling regulator 2

decreases expression

methylselenic acid results in decreased expression of CNPY2 mRNA

NCBI chr12:56,309,844...56,316,346
Ensembl chr12:56,309,842...56,316,119

G

collagen type XVI alpha 1 chain

increases expression

methylselenic acid results in increased expression of COL16A1 mRNA

NCBI chr 1:31,652,263...31,704,017
Ensembl chr 1:31,652,263...31,704,319

G

collagen type VI alpha 1 chain

increases expression

methylselenic acid results in increased expression of COL6A1 mRNA

NCBI chr21:45,981,770...46,005,048
Ensembl chr21:45,981,770...46,005,050

G

coronin 1A

increases expression

methylselenic acid results in increased expression of CORO1A mRNA

NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076

G

cellular retinoic acid binding protein 2

increases expression

methylselenic acid results in increased expression of CRABP2 mRNA

NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816

G

cAMP responsive element binding protein 1

increases expression

methylselenic acid results in increased expression of CREB1 mRNA

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

cAMP responsive element binding protein 3 like 1

decreases expression

methylselenic acid results in decreased expression of CREB3L1 mRNA

NCBI chr11:46,277,662...46,321,409
Ensembl chr11:46,277,662...46,321,409

G

cAMP responsive element binding protein 3 like 4

affects expression

methylselenic acid affects the expression of CREB3L4 mRNA

NCBI chr 1:153,967,487...153,974,359
Ensembl chr 1:153,967,534...153,974,361

G

crystallin alpha B

increases expression

methylselenic acid results in increased expression of CRYAB mRNA

NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722

G

cysteine and glycine rich protein 1

increases expression

methylselenic acid results in increased expression of CSRP1 mRNA

NCBI chr 1:201,483,530...201,507,123
Ensembl chr 1:201,483,530...201,509,456

G

cathepsin K

increases expression

methylselenic acid results in increased expression of CTSK mRNA

NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577

G

cullin 1

increases expression

methylselenic acid results in increased expression of CUL1 mRNA

NCBI chr 7:148,697,756...148,801,110
Ensembl chr 7:148,697,914...148,801,110

G

CYLD lysine 63 deubiquitinase

increases expression

methylselenic acid results in increased expression of CYLD mRNA

NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935

G

DNA damage inducible transcript 3

multiple interactions
increases expression

DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of DDIT3 protein]
methylselenic acid results in increased expression of DDIT3 mRNA; methylselenic acid results in increased expression of DDIT3 protein

PMID:11830524 PMID:12517777 PMID:16204082 PMID:16205645 PMID:19276161 More...

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DEAF1 transcription factor

decreases expression

methylselenic acid results in decreased expression of DEAF1 mRNA

NCBI chr11:644,220...707,083
Ensembl chr11:644,233...707,118

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of DHCR24 mRNA]

PMID:16020662 PMID:18548127

NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195

G

dihydrofolate reductase

decreases expression

methylselenic acid results in decreased expression of DHFR mRNA

NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983

G

DIX domain containing 1

increases expression

methylselenic acid results in increased expression of DIXDC1 mRNA

NCBI chr11:111,927,315...112,022,653
Ensembl chr11:111,927,144...112,022,653

G

dyskerin pseudouridine synthase 1

decreases expression

methylselenic acid results in decreased expression of DKC1 mRNA

NCBI chr X:154,762,864...154,777,689
Ensembl chr X:154,762,742...154,777,689

G

DLC1 Rho GTPase activating protein

increases expression

methylselenic acid results in increased expression of DLC1 mRNA

NCBI chr 8:13,083,361...13,604,620
Ensembl chr 8:13,083,361...13,604,610

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

methylselenic acid results in increased expression of DNAJB5 mRNA

NCBI chr 9:34,989,745...34,998,900
Ensembl chr 9:34,989,641...34,998,900

G

DnaJ heat shock protein family (Hsp40) member B9

affects expression

methylselenic acid affects the expression of DNAJB9 mRNA

NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

methylselenic acid results in decreased expression of DNPH1 mRNA

NCBI chr 6:43,225,629...43,229,481
Ensembl chr 6:43,225,629...43,229,481

G

dihydropyrimidine dehydrogenase

increases expression

methylselenic acid results in increased expression of DPYD mRNA

NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000

G

dihydropyrimidinase like 2

increases expression

methylselenic acid results in increased expression of DPYSL2 mRNA

NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178

G

dystrobrevin alpha

increases expression

methylselenic acid results in increased expression of DTNA mRNA

NCBI chr18:34,493,312...34,891,844
Ensembl chr18:34,493,291...34,891,844

G

deoxythymidylate kinase

decreases expression

methylselenic acid results in decreased expression of DTYMK mRNA

NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944

G

dual specificity phosphatase 10

increases expression

methylselenic acid results in increased expression of DUSP10 mRNA

NCBI chr 1:221,701,424...221,742,089
Ensembl chr 1:221,701,424...221,742,089

G

dishevelled segment polarity protein 3

increases expression

methylselenic acid results in increased expression of DVL3 mRNA

NCBI chr 3:184,155,377...184,173,614
Ensembl chr 3:184,155,377...184,173,614

G

dynein cytoplasmic 1 intermediate chain 1

increases expression

methylselenic acid results in increased expression of DYNC1I1 mRNA

NCBI chr 7:95,772,554...96,110,322
Ensembl chr 7:95,772,506...96,110,322

G

E2F transcription factor 1

affects expression
multiple interactions
decreases expression

methylselenic acid affects the expression of E2F1 mRNA
methylselenic acid promotes the reaction [E2F1 protein binds to RB1 protein]
methylselenic acid results in decreased expression of E2F1 mRNA; methylselenic acid results in decreased expression of E2F1 protein

PMID:11830524 PMID:14617803 PMID:17847021

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

G

E2F transcription factor 5

decreases expression

methylselenic acid results in decreased expression of E2F5 mRNA

NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158

G

enoyl-CoA delta isomerase 1

decreases expression

methylselenic acid results in decreased expression of ECI1 mRNA

NCBI chr16:2,239,402...2,251,587
Ensembl chr16:2,239,402...2,252,300

G

extracellular matrix protein 2

increases expression

methylselenic acid results in increased expression of ECM2 mRNA

NCBI chr 9:92,493,547...92,559,106
Ensembl chr 9:92,493,554...92,536,655

G

endothelin receptor type A

increases expression

methylselenic acid results in increased expression of EDNRA mRNA

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

endothelin receptor type B

increases expression

methylselenic acid results in increased expression of EDNRB mRNA

NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529

G

EGF containing fibulin extracellular matrix protein 2

increases expression

methylselenic acid results in increased expression of EFEMP2 mRNA

NCBI chr11:65,866,441...65,872,800
Ensembl chr11:65,866,441...65,873,592

G

early growth response 1

increases expression

methylselenic acid results in increased expression of EGR1 mRNA

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

eukaryotic translation initiation factor 2A

multiple interactions
increases phosphorylation

HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2A protein]

NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein]; methylselenic acid results in increased phosphorylation of and results in increased activity of EIF2AK3 protein

PMID:16204082 PMID:16205645

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 4 gamma 2

decreases expression

methylselenic acid results in decreased expression of EIF4G2 mRNA

NCBI chr11:10,797,046...10,808,926
Ensembl chr11:10,797,050...10,808,940

G

E74 like ETS transcription factor 3

increases expression
affects expression

methylselenic acid results in increased expression of ELF3 mRNA
methylselenic acid affects the expression of ELF3 mRNA

PMID:12517777 PMID:14617803

NCBI chr 1:202,010,587...202,017,183
Ensembl chr 1:202,007,945...202,017,183

G

enolase 2

increases expression

methylselenic acid results in increased expression of ENO2 mRNA

NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698

G

erythrocyte membrane protein band 4.1 like 2

increases expression

methylselenic acid results in increased expression of EPB41L2 mRNA

NCBI chr 6:130,839,347...131,063,245
Ensembl chr 6:130,839,347...131,063,322

G

EGFR pathway substrate 8, signaling adaptor

increases expression

methylselenic acid results in increased expression of EPS8 mRNA

NCBI chr12:15,620,134...15,789,388
Ensembl chr12:15,620,134...15,882,329

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

methylselenic acid results in increased expression of ERCC1 mRNA

NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828

G

estrogen receptor 1

multiple interactions
decreases expression

[methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 mRNA; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 protein; methylselenic acid inhibits the reaction [Estradiol binds to ESR1 protein]; methylselenic acid results in decreased expression of and results in decreased activity of ESR1 protein
methylselenic acid results in decreased expression of ESR1 mRNA; methylselenic acid results in decreased expression of ESR1 protein

PMID:15833885 PMID:16093440 PMID:16155795

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

estrogen receptor 2

increases expression
affects expression

methylselenic acid results in increased expression of ESR2 mRNA
methylselenic acid affects the expression of ESR2 mRNA

PMID:15833885 PMID:16928829

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

ETS variant transcription factor 5

increases expression

methylselenic acid results in increased expression of ETV5 mRNA

NCBI chr 3:186,046,314...186,109,089
Ensembl chr 3:186,046,314...186,110,318

G

ETS variant transcription factor 6

increases expression

methylselenic acid results in increased expression of ETV6 mRNA

NCBI chr12:11,649,674...11,895,377
Ensembl chr12:11,649,674...11,895,377

G

exostosin glycosyltransferase 1

increases expression

methylselenic acid results in increased expression of EXT1 mRNA

NCBI chr 8:117,794,490...118,111,826
Ensembl chr 8:117,794,490...118,111,826

G

family with sequence similarity 107 member A

increases expression

methylselenic acid results in increased expression of FAM107A mRNA

NCBI chr 3:58,564,117...58,627,610
Ensembl chr 3:58,564,117...58,627,610

G

F-box and leucine rich repeat protein 8

increases expression

methylselenic acid results in increased expression of FBXL8 mRNA

NCBI chr16:67,159,957...67,164,174
Ensembl chr16:67,159,932...67,164,570

G

FERM domain containing kindlin 2

increases expression

methylselenic acid results in increased expression of FERMT2 mRNA

NCBI chr14:52,857,273...52,951,050
Ensembl chr14:52,857,268...52,952,435

G

fasciculation and elongation protein zeta 1

increases expression

methylselenic acid results in increased expression of FEZ1 mRNA

NCBI chr11:125,442,881...125,496,265
Ensembl chr11:125,442,881...125,592,568

G

fibroblast growth factor 2

decreases expression

methylselenic acid results in decreased expression of FGF2 mRNA

NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236

G

four and a half LIM domains 2

increases expression

methylselenic acid results in increased expression of FHL2 mRNA

NCBI chr 2:105,357,712...105,438,529
Ensembl chr 2:105,357,712...105,438,513

G

FKBP prolyl isomerase 4

decreases expression

methylselenic acid results in decreased expression of FKBP4 mRNA

NCBI chr12:2,794,970...2,805,423
Ensembl chr12:2,794,970...2,805,423

G

FKBP prolyl isomerase 5

affects expression

methylselenic acid affects the expression of FKBP5 mRNA

NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583

G

filamin C

increases expression

methylselenic acid results in increased expression of FLNC mRNA

NCBI chr 7:128,830,406...128,859,272
Ensembl chr 7:128,830,406...128,859,274

G

fibronectin 1

affects expression

methylselenic acid affects the expression of FN1 mRNA

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

formin binding protein 1

increases expression

methylselenic acid results in increased expression of FNBP1 mRNA

NCBI chr 9:129,887,187...130,053,879
Ensembl chr 9:129,887,187...130,043,189

G

forkhead box A1

decreases expression

methylselenic acid results in decreased expression of FOXA1 mRNA

PMID:12517777 PMID:18548127

NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059

G

forkhead box O3

multiple interactions

methylselenic acid results in decreased phosphorylation of and results in increased activity of FOXO3 protein

NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774

G

FYN proto-oncogene, Src family tyrosine kinase

increases expression

methylselenic acid results in increased expression of FYN mRNA

NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452

G

GABA type A receptor associated protein like 1

increases expression

methylselenic acid results in increased expression of GABARAPL1 mRNA

NCBI chr12:10,212,877...10,223,128
Ensembl chr12:10,212,458...10,223,128

G

growth arrest and DNA damage inducible alpha

increases expression

methylselenic acid results in increased expression of GADD45A mRNA

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

methylselenic acid results in decreased expression of GALNT1 mRNA

NCBI chr18:35,580,922...35,711,834
Ensembl chr18:35,581,117...35,711,834

G

growth arrest specific 1

increases expression

methylselenic acid results in increased expression of GAS1 mRNA

NCBI chr 9:86,944,362...86,947,506
Ensembl chr 9:86,944,362...86,947,506

G

glutamine amidotransferase class 1 domain containing 3

decreases expression

methylselenic acid results in decreased expression of GATD3 mRNA

NCBI chr21:44,133,683...44,145,711
Ensembl chr21:44,133,610...44,210,114

G

guanylate binding protein 2

increases expression

methylselenic acid results in increased expression of GBP2 mRNA

NCBI chr 1:89,106,132...89,126,114
Ensembl chr 1:89,106,132...89,150,456

G

gap junction protein alpha 1

increases expression

methylselenic acid results in increased expression of GJA1 mRNA

NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727

G

G protein-coupled receptor 161

increases expression

methylselenic acid results in increased expression of GPR161 mRNA

NCBI chr 1:168,079,542...168,137,667
Ensembl chr 1:168,079,542...168,137,667

G

G protein-coupled receptor 37

increases expression

methylselenic acid results in increased expression of GPR37 mRNA

NCBI chr 7:124,743,885...124,765,792
Ensembl chr 7:124,743,885...124,765,792

G

G protein-coupled receptor kinase 5

increases expression

methylselenic acid results in increased expression of GRK5 mRNA

NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745

G

glycogen synthase kinase 3 beta

multiple interactions
decreases phosphorylation

methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]
methylselenic acid results in decreased phosphorylation of GSK3B protein

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

gelsolin

increases expression

methylselenic acid results in increased expression of GSN mRNA

NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843

G

general transcription factor IIIC subunit 1

decreases expression

methylselenic acid results in decreased expression of GTF3C1 mRNA

NCBI chr16:27,460,613...27,549,913
Ensembl chr16:27,459,555...27,549,913

G

guanylate cyclase 1 soluble subunit alpha 1

affects expression
decreases expression
multiple interactions

methylselenic acid affects the expression of GUCY1A1 mRNA
methylselenic acid results in decreased expression of GUCY1A1 mRNA
AR protein inhibits the reaction [methylselenic acid results in decreased expression of GUCY1A1 mRNA]

PMID:14617803 PMID:16020662 PMID:18548127

NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059

G

H1.0 linker histone

affects expression

methylselenic acid affects the expression of H1-0 mRNA

NCBI chr22:37,805,229...37,807,432
Ensembl chr22:37,805,229...37,807,432

G

H2A clustered histone 18

decreases expression

methylselenic acid results in decreased expression of H2AC18 mRNA

NCBI chr 1:149,842,218...149,842,750
Ensembl chr 1:149,842,218...149,842,750

G

H2A clustered histone 8

decreases expression

methylselenic acid results in decreased expression of H2AC8 mRNA

NCBI chr 6:26,216,921...26,217,437
Ensembl chr 6:26,216,921...26,217,437

G

H4 clustered histone 11

decreases expression

methylselenic acid results in decreased expression of H4C11 mRNA

NCBI chr 6:27,824,092...27,824,480
Ensembl chr 6:27,824,092...27,824,480

G

hyaluronan binding protein 4

increases expression

methylselenic acid results in increased expression of HABP4 mRNA

NCBI chr 9:96,450,102...96,491,336
Ensembl chr 9:96,450,169...96,491,336

G

3-hydroxyacyl-CoA dehydratase 2

decreases expression

methylselenic acid results in decreased expression of HACD2 mRNA

NCBI chr 3:123,491,554...123,585,053
Ensembl chr 3:123,490,820...123,585,053

G

hephaestin

increases expression

methylselenic acid results in increased expression of HEPH mRNA

NCBI chr X:66,162,671...66,268,863
Ensembl chr X:66,162,671...66,268,867

G

high mobility group nucleosomal binding domain 4

increases expression

methylselenic acid results in increased expression of HMGN4 mRNA

NCBI chr 6:26,538,366...26,546,933
Ensembl chr 6:26,538,366...26,546,933

G

heterogeneous nuclear ribonucleoprotein A/B

decreases expression

methylselenic acid results in decreased expression of HNRNPAB mRNA

NCBI chr 5:178,204,533...178,211,163
Ensembl chr 5:178,204,533...178,211,163

G

homeobox A9

decreases expression

methylselenic acid results in decreased expression of HOXA9 mRNA

NCBI chr 7:27,162,438...27,165,537
Ensembl chr 7:27,162,438...27,175,180

G

homeobox D8

increases expression

methylselenic acid results in increased expression of HOXD8 mRNA

NCBI chr 2:176,129,705...176,132,695
Ensembl chr 2:176,129,694...176,132,695

G

15-hydroxyprostaglandin dehydrogenase

increases expression

methylselenic acid results in increased expression of HPGD mRNA; methylselenic acid results in increased expression of HPGD protein

NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154

G

hematopoietic prostaglandin D synthase

increases expression

methylselenic acid results in increased expression of HPGDS mRNA

NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876

G

heat shock protein 90 beta family member 1

increases expression
multiple interactions

methylselenic acid results in increased expression of HSP90B1 protein
HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSP90B1 protein]

NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,931

G

heat shock protein family A (Hsp70) member 4 like

increases expression

methylselenic acid results in increased expression of HSPA4L mRNA

NCBI chr 4:127,781,796...127,840,733
Ensembl chr 4:127,781,821...127,840,733

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK1 protein]; HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK2 protein]; HSPA5 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP12 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of PARP1 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of DDIT3 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSP90B1 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSPA5 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2A protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein]; methylselenic acid inhibits the reaction [CASP7 protein binds to HSPA5 protein]
methylselenic acid results in increased expression of HSPA5 mRNA; methylselenic acid results in increased expression of HSPA5 protein

PMID:16204082 PMID:16205645 PMID:28161410

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

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inhibitor of DNA binding 1

decreases expression

methylselenic acid results in decreased expression of ID1 mRNA

NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515

G

inhibitor of DNA binding 2

affects expression

methylselenic acid affects the expression of ID2 mRNA

NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461

G

inhibitor of DNA binding 3

decreases expression
increases expression

methylselenic acid results in decreased expression of ID3 mRNA
methylselenic acid results in increased expression of ID3 mRNA

PMID:12517777 PMID:18548127

NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501

G

iduronate 2-sulfatase

increases expression

methylselenic acid results in increased expression of IDS mRNA

NCBI chr X:149,476,988...149,505,306
Ensembl chr X:149,476,988...149,521,096

G

interferon gamma inducible protein 16

increases expression

methylselenic acid results in increased expression of IFI16 mRNA

NCBI chr 1:158,999,976...159,055,151
Ensembl chr 1:158,999,968...159,055,155

G

interferon related developmental regulator 2

decreases expression

methylselenic acid results in decreased expression of IFRD2 mRNA

NCBI chr 3:50,287,732...50,292,429
Ensembl chr 3:50,287,732...50,292,918

G

insulin like growth factor 1

increases expression

methylselenic acid results in increased expression of IGF1 mRNA

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

immunoglobulin superfamily member 3

affects expression

methylselenic acid affects the expression of IGSF3 mRNA

NCBI chr 1:116,574,398...116,667,755
Ensembl chr 1:116,574,399...116,667,755

G

inhibitor of growth family member 1

affects expression

methylselenic acid affects the expression of ING1 mRNA

NCBI chr13:110,712,623...110,723,339
Ensembl chr13:110,712,736...110,723,339

G

inositol polyphosphate-4-phosphatase type II B

affects expression

methylselenic acid affects the expression of INPP4B mRNA

NCBI chr 4:142,023,160...142,846,535
Ensembl chr 4:142,023,160...142,847,432

G

importin 8

increases expression

methylselenic acid results in increased expression of IPO8 mRNA

NCBI chr12:30,628,988...30,695,869
Ensembl chr12:30,628,988...30,695,869

G

interferon regulatory factor 1

affects expression

methylselenic acid affects the expression of IRF1 mRNA

NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719

G

integrin subunit alpha 3

increases expression

methylselenic acid results in increased expression of ITGA3 mRNA

NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481

G

integrin subunit beta 1

decreases expression

methylselenic acid results in decreased expression of ITGB1 mRNA

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 3 binding protein

decreases expression

methylselenic acid results in decreased expression of ITGB3BP mRNA

NCBI chr 1:63,440,770...63,529,187
Ensembl chr 1:63,440,770...63,593,721

G

integrin subunit beta 4

decreases expression

methylselenic acid results in decreased expression of ITGB4 mRNA

NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818

G

integrin subunit beta 5

decreases expression

methylselenic acid results in decreased expression of ITGB5 mRNA

NCBI chr 3:124,761,948...124,901,418
Ensembl chr 3:124,761,948...124,901,418

G

inositol 1,4,5-trisphosphate receptor type 1

increases expression

methylselenic acid results in increased expression of ITPR1 mRNA

NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506

G

Janus kinase 1

affects expression
increases expression

methylselenic acid affects the expression of JAK1 mRNA
methylselenic acid results in increased expression of JAK1 mRNA

PMID:14617803 PMID:18548127

NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
affects expression

methylselenic acid results in decreased expression of JUN protein
methylselenic acid affects the expression of JUN mRNA

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

methylselenic acid results in decreased expression of JUNB mRNA

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

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potassium voltage-gated channel subfamily A regulatory beta subunit 1

increases expression

methylselenic acid results in increased expression of KCNAB1 mRNA

NCBI chr 3:156,118,211...156,539,138
Ensembl chr 3:156,037,701...156,538,756

G

potassium voltage-gated channel subfamily H member 2

increases expression

methylselenic acid results in increased expression of KCNH2 mRNA

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium inwardly rectifying channel subfamily J member 8

increases expression

methylselenic acid results in increased expression of KCNJ8 mRNA

NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600

G

KDEL endoplasmic reticulum protein retention receptor 2

decreases expression

methylselenic acid results in decreased expression of KDELR2 mRNA

NCBI chr 7:6,461,089...6,484,152
Ensembl chr 7:6,445,953...6,484,190

G

kinesin family member 11

decreases expression

methylselenic acid results in decreased expression of KIF11 mRNA

NCBI chr10:92,593,130...92,655,395
Ensembl chr10:92,574,105...92,655,395

G

kinesin family member 20B

decreases expression

methylselenic acid results in decreased expression of KIF20B mRNA

NCBI chr10:89,701,590...89,774,934
Ensembl chr10:89,701,590...89,774,939

G

KLF transcription factor 4

multiple interactions
increases expression
increases activity
affects expression

KLF4 protein affects the reaction [methylselenic acid results in decreased expression of CCND1 mRNA]; KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1B mRNA]
methylselenic acid results in increased expression of KLF4 mRNA
methylselenic acid results in increased activity of KLF4 protein
methylselenic acid affects the expression of KLF4 mRNA

PMID:14617803 PMID:18314491

NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482

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kelch like family member 2

affects expression

methylselenic acid affects the expression of KLHL2 mRNA

NCBI chr 4:165,207,561...165,323,156
Ensembl chr 4:165,207,561...165,323,156

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kallikrein related peptidase 2

multiple interactions
decreases expression
affects expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK2 mRNA]
methylselenic acid affects the expression of KLK2 mRNA

PMID:14617803 PMID:16020662 PMID:18548127

NCBI chr19:50,873,439...50,880,567
Ensembl chr19:50,861,568...50,880,567

G

kallikrein related peptidase 3

multiple interactions
decreases secretion
decreases expression
affects expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK3 mRNA]; methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [mibolerone results in increased expression of KLK3 mRNA]; methylselenic acid results in increased degradation of and results in decreased expression of and results in decreased secretion of KLK3 protein
methylselenic acid results in decreased secretion of KLK3 protein
methylselenic acid results in decreased expression of KLK3 mRNA; methylselenic acid results in decreased expression of KLK3 protein
methylselenic acid affects the expression of KLK3 mRNA

PMID:14617803 PMID:15141018 PMID:16020662 PMID:16648561 PMID:16928829 More...

NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764

G

keratin 15

increases expression

methylselenic acid results in increased expression of KRT15 mRNA

NCBI chr17:41,513,745...41,518,890
Ensembl chr17:41,513,745...41,522,529

G

keratin 20

increases expression

methylselenic acid results in increased expression of KRT20 mRNA

NCBI chr17:40,875,889...40,885,242
Ensembl chr17:40,875,889...40,885,242

G

L antigen family member 3

decreases expression

methylselenic acid results in decreased expression of LAGE3 mRNA

NCBI chr X:154,477,775...154,479,281
Ensembl chr X:154,477,775...154,479,281

G

laminin subunit alpha 4

increases expression

methylselenic acid results in increased expression of LAMA4 mRNA

NCBI chr 6:112,107,931...112,254,985
Ensembl chr 6:112,107,931...112,254,939

G

laminin subunit beta 3

increases expression

methylselenic acid results in increased expression of LAMB3 mRNA

NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425

G

lamin B2

decreases expression

methylselenic acid results in decreased expression of LMNB2 mRNA

NCBI chr19:2,428,166...2,456,959
Ensembl chr19:2,427,638...2,456,959

G

lysophospholipase 1

decreases expression

methylselenic acid results in decreased expression of LYPLA1 mRNA

NCBI chr 8:54,046,367...54,101,947
Ensembl chr 8:54,046,367...54,102,017

G

macrophage erythroblast attacher, E3 ubiquitin ligase

decreases expression

methylselenic acid results in decreased expression of MAEA mRNA

NCBI chr 4:1,289,891...1,340,137
Ensembl chr 4:1,289,887...1,340,147

G

MAF bZIP transcription factor

increases expression

methylselenic acid results in increased expression of MAF mRNA

NCBI chr16:79,202,622...79,600,737
Ensembl chr16:79,585,843...79,600,737

G

microtubule associated protein 1B

affects expression
increases expression

methylselenic acid affects the expression of MAP1B mRNA
methylselenic acid results in increased expression of MAP1B mRNA

PMID:14617803 PMID:18548127

NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565

G

mitogen-activated protein kinase kinase 1

decreases expression
increases expression

methylselenic acid results in decreased expression of MAP2K1 mRNA
methylselenic acid results in increased expression of MAP2K1 mRNA

PMID:11830524 PMID:12517777

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase kinase 5

increases expression

methylselenic acid results in increased expression of MAP2K5 mRNA

NCBI chr15:67,542,703...67,807,114
Ensembl chr15:67,542,703...67,807,117

G

mitogen-activated protein kinase 1

increases phosphorylation

methylselenic acid results in increased phosphorylation of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases expression
increases phosphorylation

methylselenic acid results in increased expression of MAPK3 mRNA
methylselenic acid results in increased phosphorylation of MAPK3 protein

PMID:11830524 PMID:15845651

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

increases expression

methylselenic acid results in increased expression of MAPK8 mRNA

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

decreases expression

methylselenic acid results in decreased expression of MAPK9 mRNA

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

microtubule associated protein RP/EB family member 2

increases expression

methylselenic acid results in increased expression of MAPRE2 mRNA

NCBI chr18:34,977,027...35,143,470
Ensembl chr18:34,976,928...35,143,470

G

microtubule associated protein tau

decreases expression

methylselenic acid results in decreased expression of MAPT mRNA

NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334

G

MYC associated zinc finger protein

decreases expression

methylselenic acid results in decreased expression of MAZ mRNA

NCBI chr16:29,806,124...29,811,164
Ensembl chr16:29,806,106...29,811,164

G

muscleblind like splicing regulator 2

increases expression

methylselenic acid results in increased expression of MBNL2 mRNA

NCBI chr13:97,141,834...97,394,120
Ensembl chr13:97,221,434...97,394,120

G

methylcrotonyl-CoA carboxylase subunit 2

decreases expression

methylselenic acid results in decreased expression of MCCC2 mRNA

NCBI chr 5:71,587,340...71,658,706
Ensembl chr 5:71,579,531...71,658,706

G

minichromosome maintenance complex component 2

affects expression

methylselenic acid affects the expression of MCM2 mRNA

NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436

G

minichromosome maintenance complex component 3

decreases expression

methylselenic acid results in decreased expression of MCM3 mRNA

NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881

G

minichromosome maintenance complex component 5

decreases expression

methylselenic acid results in decreased expression of MCM5 mRNA

NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431

G

minichromosome maintenance complex component 6

decreases expression
affects expression

methylselenic acid results in decreased expression of MCM6 mRNA
methylselenic acid affects the expression of MCM6 mRNA

PMID:12517777 PMID:14617803

NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443

G

minichromosome maintenance complex component 7

decreases expression

methylselenic acid results in decreased expression of MCM7 mRNA

NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,233...100,101,940

G

malic enzyme 1

increases expression

methylselenic acid results in increased expression of ME1 mRNA

NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051

G

myocyte enhancer factor 2C

increases expression

methylselenic acid results in increased expression of MEF2C mRNA

NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257

G

menin 1

affects expression

methylselenic acid affects the expression of MEN1 mRNA

NCBI chr11:64,803,516...64,811,294
Ensembl chr11:64,803,510...64,811,294

G

mitochondrial calcium uptake 2

decreases expression

methylselenic acid results in decreased expression of MICU2 mRNA

NCBI chr13:21,492,691...21,604,170
Ensembl chr13:21,492,691...21,604,181

G

melanocyte inducing transcription factor

increases expression

methylselenic acid results in increased expression of MITF mRNA

NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,456...69,968,336

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marker of proliferation Ki-67

decreases expression

methylselenic acid results in decreased expression of MKI67 mRNA

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

mitochondrial ribosomal protein L19

decreases expression

methylselenic acid results in decreased expression of MRPL19 mRNA

NCBI chr 2:75,646,783...75,662,206
Ensembl chr 2:75,646,783...75,690,851

G

MAX dimerization protein 1

affects expression

methylselenic acid affects the expression of MXD1 mRNA

NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945

G

MAX interactor 1, dimerization protein

increases expression

methylselenic acid results in increased expression of MXI1 mRNA

NCBI chr10:110,207,605...110,287,365
Ensembl chr10:110,207,605...110,287,365

G

MYB proto-oncogene like 2

decreases expression

methylselenic acid results in decreased expression of MYBL2 mRNA

NCBI chr20:43,667,114...43,716,482
Ensembl chr20:43,667,019...43,716,495

G

MYC proto-oncogene, bHLH transcription factor

affects expression
multiple interactions

methylselenic acid affects the expression of MYC mRNA
methylselenic acid inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]

PMID:14617803 PMID:15833885 PMID:16093440 PMID:16155795

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

myosin light chain 9

increases expression

methylselenic acid results in increased expression of MYL9 mRNA

NCBI chr20:36,541,519...36,551,447
Ensembl chr20:36,541,497...36,551,447

G

myosin X

decreases expression

methylselenic acid results in decreased expression of MYO10 mRNA

NCBI chr 5:16,661,907...16,936,288
Ensembl chr 5:16,661,907...16,936,288

G

myosin VIIA and Rab interacting protein

decreases expression

methylselenic acid results in decreased expression of MYRIP mRNA

NCBI chr 3:39,808,914...40,260,321
Ensembl chr 3:39,808,914...40,260,321

G

N-acylethanolamine acid amidase

decreases expression

methylselenic acid results in decreased expression of NAAA mRNA

NCBI chr 4:75,910,655...75,941,013
Ensembl chr 4:75,913,660...75,941,013

G

nuclear receptor coactivator 1

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]

NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702

G

nuclear receptor coactivator 2

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]

NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808

G

nuclear receptor corepressor 1

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]

NCBI chr17:16,029,157...16,215,534
Ensembl chr17:16,029,065...16,218,185

G

nuclear receptor corepressor 2

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]

NCBI chr12:124,324,415...124,567,612
Ensembl chr12:124,324,415...124,567,612

G

N-myc downstream regulated 1

affects expression

methylselenic acid affects the expression of NDRG1 mRNA

NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022

G

nebulette

increases expression

methylselenic acid results in increased expression of NEBL mRNA

NCBI chr10:20,779,973...21,293,050
Ensembl chr10:20,779,973...21,293,011

G

nuclear factor, interleukin 3 regulated

affects expression

methylselenic acid affects the expression of NFIL3 mRNA

NCBI chr 9:91,409,045...91,483,497
Ensembl chr 9:91,409,045...91,423,832

G

nuclear factor kappa B subunit 1

decreases expression

methylselenic acid results in decreased expression of NFKB1 mRNA

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NK3 homeobox 1

affects expression

methylselenic acid affects the expression of NKX3-1 mRNA

NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938

G

NME/NM23 nucleoside diphosphate kinase 1

decreases expression

methylselenic acid results in decreased expression of NME1 mRNA

NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428

G

NME/NM23 nucleoside diphosphate kinase 4

decreases expression

methylselenic acid results in decreased expression of NME4 mRNA

NCBI chr16:396,729...400,754
Ensembl chr16:396,725...410,367

G

N-myc and STAT interactor

decreases expression

methylselenic acid results in decreased expression of NMI mRNA

NCBI chr 2:151,270,470...151,289,668
Ensembl chr 2:151,270,470...151,289,894

G

NAD(P)H quinone dehydrogenase 1

increases activity

methylselenic acid results in increased activity of NQO1 protein

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

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nuclear receptor subfamily 3 group C member 1

affects expression

methylselenic acid affects the expression of NR3C1 mRNA

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

ornithine aminotransferase

increases expression

methylselenic acid results in increased expression of OAT mRNA

NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976

G

olfactomedin like 2A

increases expression

methylselenic acid results in increased expression of OLFML2A mRNA

NCBI chr 9:124,777,133...124,814,882
Ensembl chr 9:124,777,133...124,814,885

G

optineurin

increases expression

methylselenic acid results in increased expression of OPTN mRNA

NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308

G

PALM2 and AKAP2 fusion

increases expression

methylselenic acid results in increased expression of PALM2AKAP2 mRNA

NCBI chr 9:109,640,787...110,172,512
Ensembl chr 9:109,498,325...110,172,512

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poly(ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of PARP1 protein; [Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of PARP1 protein]; SB 216763 inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]

PMID:15845651 PMID:16204082 PMID:17339365 PMID:18444175 PMID:19276161 More...

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

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POZ/BTB and AT hook containing zinc finger 1

decreases expression

methylselenic acid results in decreased expression of PATZ1 mRNA

NCBI chr22:31,325,804...31,346,346
Ensembl chr22:31,325,804...31,346,346

G

PAX interacting protein 1

decreases expression

methylselenic acid results in decreased expression of PAXIP1 mRNA

NCBI chr 7:154,943,690...155,003,411
Ensembl chr 7:154,943,687...155,003,124

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PBX homeobox 1

increases expression

methylselenic acid results in increased expression of PBX1 mRNA

NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296

G

pterin-4 alpha-carbinolamine dehydratase 1

decreases expression

methylselenic acid results in decreased expression of PCBD1 mRNA

NCBI chr10:70,882,280...70,888,565
Ensembl chr10:70,882,280...70,888,565

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proliferating cell nuclear antigen

affects expression
decreases expression

methylselenic acid affects the expression of PCNA mRNA
methylselenic acid results in decreased expression of PCNA mRNA

PMID:11830524 PMID:12517777 PMID:14617803

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

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paternally expressed 3

affects expression

methylselenic acid affects the expression of PEG3 mRNA

NCBI chr19:56,810,082...56,840,726
Ensembl chr19:56,810,077...56,840,728

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prefoldin subunit 5

decreases expression

methylselenic acid results in decreased expression of PFDN5 mRNA

NCBI chr12:53,295,542...53,299,450
Ensembl chr12:53,295,291...53,299,452

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post-GPI attachment to proteins 2

decreases expression

methylselenic acid results in decreased expression of PGAP2 mRNA

NCBI chr11:3,797,724...3,826,371
Ensembl chr11:3,797,724...3,826,371

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phosphoglucomutase 5

increases expression

methylselenic acid results in increased expression of PGM5 mRNA

NCBI chr 9:68,356,611...68,531,061
Ensembl chr 9:68,328,308...68,531,061

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progesterone receptor

affects expression

methylselenic acid affects the expression of PGR mRNA

NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813

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praja ring finger ubiquitin ligase 2

increases expression

methylselenic acid results in increased expression of PJA2 mRNA

NCBI chr 5:109,334,722...109,409,974
Ensembl chr 5:109,334,713...109,409,974

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phospholipase A2 group IVA

increases expression

methylselenic acid results in increased expression of PLA2G4A mRNA

NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981

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phospholipase C beta 4

increases expression

methylselenic acid results in increased expression of PLCB4 mRNA

NCBI chr20:9,068,678...9,480,808
Ensembl chr20:9,067,825...9,504,593

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polo like kinase 1

decreases expression
affects expression

methylselenic acid results in decreased expression of PLK1 mRNA
methylselenic acid affects the expression of PLK1 mRNA

PMID:11830524 PMID:14617803

NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367

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PMS1 homolog 2, mismatch repair system component

increases expression

methylselenic acid results in increased expression of PMS2 mRNA

NCBI chr 7:5,970,925...6,009,106
Ensembl chr 7:5,970,925...6,009,130

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DNA polymerase alpha 1, catalytic subunit

decreases expression

methylselenic acid results in decreased expression of POLA1 mRNA

NCBI chr X:24,693,918...24,996,986
Ensembl chr X:24,693,873...24,996,986

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RNA polymerase II, I and III subunit H

decreases expression

methylselenic acid results in decreased expression of POLR2H mRNA

NCBI chr 3:184,361,710...184,368,591
Ensembl chr 3:184,361,710...184,368,596

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PTPRF interacting protein alpha 1

affects expression

methylselenic acid affects the expression of PPFIA1 mRNA

NCBI chr11:70,270,690...70,384,396
Ensembl chr11:70,270,690...70,385,312

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peptidylprolyl isomerase like 2

decreases expression

methylselenic acid results in decreased expression of PPIL2 mRNA

NCBI chr22:21,666,012...21,700,015
Ensembl chr22:21,666,000...21,700,015

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protein phosphatase, Mg2+/Mn2+ dependent 1B

increases expression

methylselenic acid results in increased expression of PPM1B mRNA

NCBI chr 2:44,168,875...44,246,928
Ensembl chr 2:44,167,969...44,244,384

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protein phosphatase 1 regulatory subunit 15A

increases expression

methylselenic acid results in increased expression of PPP1R15A mRNA

NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059

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protein kinase cAMP-dependent type II regulatory subunit beta

increases expression

methylselenic acid results in increased expression of PRKAR2B mRNA

NCBI chr 7:107,044,705...107,161,811
Ensembl chr 7:107,044,705...107,161,811

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protein kinase C alpha

increases expression

methylselenic acid results in increased expression of PRKCA mRNA

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

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protein kinase C beta

increases expression

methylselenic acid results in increased expression of PRKCB mRNA

NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611

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prion protein (Kanno blood group)

increases expression

methylselenic acid results in increased expression of PRNP mRNA

NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590

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phosphatase and tensin homolog

increases expression

methylselenic acid results in increased expression of PTEN mRNA

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

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prostaglandin E synthase

decreases expression

methylselenic acid results in decreased expression of PTGES mRNA

PMID:11830524 PMID:21669866

NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042

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QKI, KH domain containing RNA binding

increases expression

methylselenic acid results in increased expression of QKI mRNA

NCBI chr 6:163,414,718...163,578,592
Ensembl chr 6:163,414,000...163,578,592

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RAB28, member RAS oncogene family

increases expression

methylselenic acid results in increased expression of RAB28 mRNA

NCBI chr 4:13,367,724...13,484,340
Ensembl chr 4:13,361,354...13,484,365

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RAB31, member RAS oncogene family

increases expression
affects expression

methylselenic acid results in increased expression of RAB31 mRNA
methylselenic acid affects the expression of RAB31 mRNA

PMID:12517777 PMID:14617803 PMID:18548127

NCBI chr18:9,708,301...9,862,551
Ensembl chr18:9,708,275...9,862,551

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Rab acceptor 1

decreases expression

methylselenic acid results in decreased expression of RABAC1 mRNA

NCBI chr19:41,956,683...41,959,321
Ensembl chr19:41,956,681...41,959,321

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RAD9 checkpoint clamp component A

increases expression

methylselenic acid results in increased expression of RAD9A mRNA

NCBI chr11:67,391,986...67,398,412
Ensembl chr11:67,317,871...67,398,410

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Rap guanine nucleotide exchange factor 4

increases expression

methylselenic acid results in increased expression of RAPGEF4 mRNA

NCBI chr 2:172,735,318...173,052,893
Ensembl chr 2:172,735,274...173,052,893

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RB transcriptional corepressor 1

multiple interactions

methylselenic acid promotes the reaction [E2F1 protein binds to RB1 protein]; methylselenic acid results in decreased phosphorylation of and results in increased expression of RB1 protein

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

retinol dehydrogenase 11

affects expression

methylselenic acid affects the expression of RDH11 mRNA

NCBI chr14:67,676,800...67,695,764
Ensembl chr14:67,676,800...67,695,793

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receptor accessory protein 1

increases expression

methylselenic acid results in increased expression of REEP1 mRNA

NCBI chr 2:86,213,993...86,338,083
Ensembl chr 2:86,213,993...86,338,083

G

replication factor C subunit 5

decreases expression

methylselenic acid results in decreased expression of RFC5 mRNA

NCBI chr12:118,016,703...118,041,448
Ensembl chr12:118,013,588...118,033,130

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ral guanine nucleotide dissociation stimulator like 1

increases expression

methylselenic acid results in increased expression of RGL1 mRNA

NCBI chr 1:183,636,109...183,928,532
Ensembl chr 1:183,636,085...183,928,532

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regulator of G protein signaling 10

increases expression

methylselenic acid results in increased expression of RGS10 mRNA

NCBI chr10:119,499,817...119,542,719
Ensembl chr10:119,499,817...119,542,719

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ras homolog family member B

affects expression

methylselenic acid affects the expression of RHOB mRNA

NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440

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regulating synaptic membrane exocytosis 3

increases expression

methylselenic acid results in increased expression of RIMS3 mRNA

NCBI chr 1:40,620,680...40,692,066
Ensembl chr 1:40,620,680...40,665,682

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Rho family GTPase 3

increases expression

methylselenic acid results in increased expression of RND3 mRNA

NCBI chr 2:150,468,193...150,487,695
Ensembl chr 2:150,468,195...150,539,011

G

replication protein A2

decreases expression

methylselenic acid results in decreased expression of RPA2 mRNA

NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746

G

ribose 5-phosphate isomerase A

decreases expression

methylselenic acid results in decreased expression of RPIA mRNA

NCBI chr 2:88,691,673...88,750,929
Ensembl chr 2:88,691,673...88,750,929

G

ribosomal protein L27a

decreases expression

methylselenic acid results in decreased expression of RPL27A mRNA

NCBI chr11:8,682,792...8,689,872
Ensembl chr11:8,682,788...8,714,759

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ribosomal protein SA

decreases expression

methylselenic acid results in decreased expression of RPSA mRNA

NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,426,255

G

ribonucleotide reductase catalytic subunit M1

affects expression

methylselenic acid affects the expression of RRM1 mRNA

NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932

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ribonucleotide reductase regulatory subunit M2

affects expression

methylselenic acid affects the expression of RRM2 mRNA

NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725

G

ribitol xylosyltransferase 1

decreases expression

methylselenic acid results in decreased expression of RXYLT1 mRNA

NCBI chr12:63,779,909...63,809,562
Ensembl chr12:63,779,833...63,809,792

G

S100 calcium binding protein A4

increases expression

methylselenic acid results in increased expression of S100A4 mRNA

NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136

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sterile alpha motif domain containing 4A

increases expression

methylselenic acid results in increased expression of SAMD4 mRNA

NCBI chr14:54,565,316...54,793,315
Ensembl chr14:54,566,117...54,793,315

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spermidine/spermine N1-acetyltransferase 1

affects expression

methylselenic acid affects the expression of SAT1 mRNA

NCBI chr X:23,783,173...23,786,210
Ensembl chr X:23,783,173...23,786,210

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stearoyl-CoA desaturase

affects expression

methylselenic acid affects the expression of SCD mRNA

NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826

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syndecan 2

increases expression

methylselenic acid results in increased expression of SDC2 mRNA

NCBI chr 8:96,493,813...96,611,790
Ensembl chr 8:96,493,813...96,611,790

G

SEC24 homolog D, COPII coat complex component

affects expression

methylselenic acid affects the expression of SEC24D mRNA

NCBI chr 4:118,722,823...118,836,126
Ensembl chr 4:118,722,823...118,838,683

G

semaphorin 5A

increases expression

methylselenic acid results in increased expression of SEMA5A mRNA

NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075

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serpin family B member 5

increases expression
affects expression

methylselenic acid results in increased expression of SERPINB5 mRNA
methylselenic acid affects the expression of SERPINB5 mRNA

PMID:14617803 PMID:18548127

NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085

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serpin family B member 6

decreases expression

methylselenic acid results in decreased expression of SERPINB6 mRNA

NCBI chr 6:2,948,159...2,971,793
Ensembl chr 6:2,948,159...2,972,165

G

serpin family E member 2

increases expression

methylselenic acid results in increased expression of SERPINE2 mRNA

NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318

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serpin family F member 1

increases expression

methylselenic acid results in increased expression of SERPINF1 mRNA

NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565

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serum/glucocorticoid regulated kinase 1

affects expression

methylselenic acid affects the expression of SGK1 mRNA

NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112

G

SH3 domain binding glutamate rich protein

increases expression

methylselenic acid results in increased expression of SH3BGR mRNA

NCBI chr21:39,445,865...39,515,506
Ensembl chr21:39,445,855...39,515,506

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SH3 domain binding protein 5

affects expression

methylselenic acid affects the expression of SH3BP5 mRNA

NCBI chr 3:15,254,353...15,341,380
Ensembl chr 3:15,254,353...15,341,368

G

solute carrier family 14 member 1 (Kidd blood group)

increases expression

methylselenic acid results in increased expression of SLC14A1 mRNA

NCBI chr18:45,724,181...45,752,520
Ensembl chr18:45,687,025...45,752,520

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solute carrier family 16 member 7

increases expression

methylselenic acid results in increased expression of SLC16A7 mRNA

NCBI chr12:59,596,029...59,789,841
Ensembl chr12:59,596,029...59,789,855

G

solute carrier family 19 member 1

decreases expression

methylselenic acid results in decreased expression of SLC19A1 mRNA

NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365

G

SMAD family member 7

increases expression

methylselenic acid results in increased expression of SMAD7 mRNA

NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

decreases expression

methylselenic acid results in decreased expression of SMARCA4 mRNA

NCBI chr19:10,961,030...11,062,273
Ensembl chr19:10,960,932...11,079,426

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

increases expression

methylselenic acid results in increased expression of SMARCD3 mRNA

NCBI chr 7:151,238,780...151,277,149
Ensembl chr 7:151,238,764...151,277,896

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

decreases expression

methylselenic acid results in decreased expression of SMARCE1 mRNA

NCBI chr17:40,624,962...40,647,818
Ensembl chr17:40,624,962...40,648,654

G

snail family transcriptional repressor 2

increases expression

methylselenic acid results in increased expression of SNAI2 mRNA

NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740

G

synaptosome associated protein 25

increases expression

methylselenic acid results in increased expression of SNAP25 mRNA

NCBI chr20:10,218,830...10,307,418
Ensembl chr20:10,172,395...10,308,258

G

synuclein gamma

increases expression

methylselenic acid results in increased expression of SNCG mRNA

NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258

G

staphylococcal nuclease and tudor domain containing 1

decreases expression

methylselenic acid results in decreased expression of SND1 mRNA

NCBI chr 7:127,652,194...128,092,593
Ensembl chr 7:127,652,194...128,092,609

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small nucleolar RNA host gene 16

increases expression

methylselenic acid results in increased expression of SNHG16 mRNA

NCBI chr17:76,557,764...76,565,348
Ensembl chr17:76,557,727...76,670,985

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sorting nexin 1

increases expression

methylselenic acid results in increased expression of SNX1 mRNA

NCBI chr15:64,095,982...64,144,231
Ensembl chr15:64,094,123...64,146,090

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sorbin and SH3 domain containing 1

increases expression

methylselenic acid results in increased expression of SORBS1 mRNA

NCBI chr10:95,311,773...95,561,371
Ensembl chr10:95,311,771...95,561,414

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Sp1 transcription factor

multiple interactions

methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]

NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446

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SAM pointed domain containing ETS transcription factor

increases expression

methylselenic acid results in increased expression of SPDEF protein

NCBI chr 6:34,537,802...34,556,329
Ensembl chr 6:34,537,802...34,556,333

G

spectrin alpha, non-erythrocytic 1

increases expression

methylselenic acid results in increased expression of SPTAN1 mRNA

NCBI chr 9:128,552,587...128,633,662
Ensembl chr 9:128,552,558...128,633,662

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signal recognition particle 19

decreases expression

methylselenic acid results in decreased expression of SRP19 mRNA

NCBI chr 5:112,861,287...112,898,371
Ensembl chr 5:112,861,188...112,898,371

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single stranded DNA binding protein 2

increases expression

methylselenic acid results in increased expression of SSBP2 mRNA

NCBI chr 5:81,412,804...81,751,807
Ensembl chr 5:81,412,804...81,751,797

G

suppression of tumorigenicity 7

decreases expression
affects expression

methylselenic acid results in decreased expression of ST7 mRNA
methylselenic acid affects the expression of ST7 mRNA

PMID:14617803 PMID:18548127

NCBI chr 7:116,953,501...117,230,176
Ensembl chr 7:116,953,238...117,230,176

G

stomatin

increases expression

methylselenic acid results in increased expression of STOM mRNA

NCBI chr 9:121,338,987...121,370,250
Ensembl chr 9:121,338,987...121,370,304

G

syntaxin 12

increases expression

methylselenic acid results in increased expression of STX12 mRNA

NCBI chr 1:27,773,219...27,824,443
Ensembl chr 1:27,773,219...27,824,443

G

syntaxin 1A

affects expression

methylselenic acid affects the expression of STX1A mRNA

NCBI chr 7:73,699,210...73,719,669
Ensembl chr 7:73,699,206...73,719,672

G

syntaxin 2

increases expression

methylselenic acid results in increased expression of STX2 mRNA

NCBI chr12:130,789,600...130,839,250
Ensembl chr12:130,789,600...130,839,254

G

supervillin

increases expression

methylselenic acid results in increased expression of SVIL mRNA

NCBI chr10:29,457,338...29,736,936
Ensembl chr10:29,457,338...29,736,959

G

tumor associated calcium signal transducer 2

decreases expression

methylselenic acid results in decreased expression of TACSTD2 mRNA

NCBI chr 1:58,575,433...58,577,252
Ensembl chr 1:58,575,433...58,577,252

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TARBP2 subunit of RISC loading complex

decreases expression

methylselenic acid results in decreased expression of TARBP2 mRNA

NCBI chr12:53,500,923...53,506,431
Ensembl chr12:53,500,921...53,506,431

G

transducin beta like 1 X-linked

increases expression

methylselenic acid results in increased expression of TBL1X mRNA

NCBI chr X:9,463,295...9,719,740
Ensembl chr X:9,463,320...9,741,037

G

thromboxane A synthase 1

decreases expression

methylselenic acid results in decreased expression of TBXAS1 mRNA

NCBI chr 7:139,778,242...140,020,293
Ensembl chr 7:139,777,051...140,020,325

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transcobalamin 2

increases expression

methylselenic acid results in increased expression of TCN2 mRNA

NCBI chr22:30,607,174...30,627,271
Ensembl chr22:30,607,003...30,627,271

G

trefoil factor 1

multiple interactions

methylselenic acid inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; methylselenic acid inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]

PMID:16093440 PMID:16155795

NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535

G

transforming growth factor beta 1

increases expression

methylselenic acid results in increased expression of TGFB1 mRNA

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 2

increases expression

methylselenic acid results in increased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

transforming growth factor beta receptor 2

increases expression

methylselenic acid results in increased expression of TGFBR2 mRNA

NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142

G

transforming growth factor beta receptor 3

increases expression

methylselenic acid results in increased expression of TGFBR3 mRNA

PMID:12517777 PMID:18548127

NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335

G

TLE family member 2, transcriptional corepressor

increases expression

methylselenic acid results in increased expression of TLE2 mRNA

NCBI chr19:2,997,644...3,047,635
Ensembl chr19:2,997,639...3,047,635

G

toll like receptor 2

increases expression

methylselenic acid results in increased expression of TLR2 mRNA

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260

G

transmembrane serine protease 2

affects expression

methylselenic acid affects the expression of TMPRSS2 mRNA

NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116

G

TNF alpha induced protein 3

affects expression

methylselenic acid affects the expression of TNFAIP3 mRNA

NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314

G

TNF receptor superfamily member 25

increases expression

methylselenic acid results in increased expression of TNFRSF25 mRNA

NCBI chr 1:6,460,786...6,466,173
Ensembl chr 1:6,460,786...6,466,175

G

DNA topoisomerase II alpha

affects expression

methylselenic acid affects the expression of TOP2A mRNA

NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896

G

torsin 1A interacting protein 1

increases expression

methylselenic acid results in increased expression of TOR1AIP1 mRNA

NCBI chr 1:179,882,285...179,920,076
Ensembl chr 1:179,882,042...179,920,077

G

TP53 target 1

decreases expression

methylselenic acid results in decreased expression of TP53TG1 mRNA

NCBI chr 7:87,325,347...87,345,492
Ensembl chr 7:87,322,943...87,345,560

G

tropomyosin 1

increases expression

methylselenic acid results in increased expression of TPM1 mRNA

NCBI chr15:63,042,747...63,071,915
Ensembl chr15:63,042,620...63,071,915

G

tribbles pseudokinase 1

decreases expression

methylselenic acid results in decreased expression of TRIB1 mRNA

NCBI chr 8:125,430,358...125,438,403
Ensembl chr 8:125,430,358...125,438,403

G

tripartite motif containing 14

decreases expression

methylselenic acid results in decreased expression of TRIM14 mRNA

NCBI chr 9:98,035,797...98,119,222
Ensembl chr 9:98,069,275...98,119,222

G

TTK protein kinase

decreases expression

methylselenic acid results in decreased expression of TTK mRNA

NCBI chr 6:80,004,649...80,042,527
Ensembl chr 6:80,003,887...80,042,527

G

thioredoxin reductase 1

increases metabolic processing

TXNRD1 protein results in increased metabolism of methylselenic acid

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thymidylate synthetase

decreases expression
affects expression

methylselenic acid results in decreased expression of TYMS mRNA
methylselenic acid affects the expression of TYMS mRNA

PMID:12517777 PMID:14617803

NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578

G

uridine-cytidine kinase 2

decreases expression

methylselenic acid results in decreased expression of UCK2 mRNA

NCBI chr 1:165,827,614...165,911,618
Ensembl chr 1:165,827,614...165,911,618

G

UDP-glucose 6-dehydrogenase

affects expression

methylselenic acid affects the expression of UGDH mRNA

NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311

G

utrophin

decreases expression

methylselenic acid results in decreased expression of UTRN mRNA

NCBI chr 6:144,285,335...144,853,034
Ensembl chr 6:144,285,335...144,853,034

G

vesicle associated membrane protein 3

increases expression

methylselenic acid results in increased expression of VAMP3 mRNA

NCBI chr 1:7,771,296...7,781,432
Ensembl chr 1:7,771,296...7,781,432

G

vitamin D receptor

affects expression

methylselenic acid affects the expression of VDR mRNA

NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048

G

vascular endothelial growth factor C

decreases expression

methylselenic acid results in decreased expression of VEGFC mRNA

NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922

G

vimentin

increases expression

methylselenic acid results in increased expression of VIM mRNA

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

WASP family member 1

affects expression

methylselenic acid affects the expression of WASF1 mRNA

NCBI chr 6:110,099,819...110,179,670
Ensembl chr 6:110,099,819...110,180,004

G

Wnt family member 7A

decreases expression

methylselenic acid results in decreased expression of WNT7A mRNA

NCBI chr 3:13,816,258...13,880,071
Ensembl chr 3:13,816,258...13,880,071

G

WD repeat and SOCS box containing 2

decreases expression

methylselenic acid results in decreased expression of WSB2 mRNA

NCBI chr12:118,032,687...118,062,174
Ensembl chr12:118,032,687...118,062,430

G

X-box binding protein 1

increases splicing

methylselenic acid results in increased splicing of XBP1 mRNA

PMID:16205645 PMID:28161410

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

decreases expression

methylselenic acid results in decreased expression of YWHAE mRNA

NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222

G

zinc finger CCHC-type containing 24

increases expression

methylselenic acid results in increased expression of ZCCHC24 mRNA

NCBI chr10:79,382,325...79,445,624
Ensembl chr10:79,382,325...79,445,624

G

zinc finger protein 165

increases expression

methylselenic acid results in increased expression of ZNF165 mRNA

NCBI chr 6:28,080,282...28,089,563
Ensembl chr 6:28,080,568...28,089,563

G

zinc finger protein 217

increases expression

methylselenic acid results in increased expression of ZNF217 mRNA

NCBI chr20:53,567,071...53,597,702
Ensembl chr20:53,567,071...53,609,907

G

zinc finger protein 24

decreases expression

methylselenic acid results in decreased expression of ZNF24 mRNA

NCBI chr18:35,332,227...35,344,420
Ensembl chr18:35,332,227...35,345,482

G

zinc finger protein 267

increases expression

methylselenic acid results in increased expression of ZNF267 mRNA

NCBI chr16:31,873,807...31,917,357
Ensembl chr16:31,873,807...31,917,357

G

zinc finger protein 274

increases expression

methylselenic acid results in increased expression of ZNF274 mRNA

NCBI chr19:58,183,061...58,213,562
Ensembl chr19:58,183,029...58,213,562

G

zinc finger protein 345

increases expression

methylselenic acid results in increased expression of ZNF345 mRNA

NCBI chr19:36,850,365...36,893,218
Ensembl chr19:36,850,361...36,913,029

G

zinc finger protein 43

decreases expression

methylselenic acid results in decreased expression of ZNF43 mRNA

NCBI chr19:21,804,946...21,852,065
Ensembl chr19:21,804,946...21,852,125

G

zinc finger protein 75D

increases expression

methylselenic acid results in increased expression of ZNF75D mRNA

NCBI chr X:135,248,589...135,344,109
Ensembl chr X:135,248,920...135,344,109

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26041
role	25957
application	25179
pharmaceutical	24553
drug	24550
antineoplastic agent	20858
methylseleninic acid	413
Path 2
Term	Annotations
CHEBI ontology	26041
subatomic particle	26016
composite particle	26016
hadron	26016
baryon	26016
nucleon	26016
atomic nucleus	26016
atom	26016
main group element atom	25841
p-block element atom	25841
chalcogen	24924
oxygen atom	24814
oxygen molecular entity	24814
hydroxides	24056
oxoacid	22984
chalcogen oxoacid	14522
selenium oxoacid	1896
seleninic acid	413
methylseleninic acid	413

paths to the root