methylseleninic acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	methylseleninic acid	go back to main search page
Accession:	CHEBI:77012	browse the term
Definition:	An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Synonyms:	exact_synonym:	methaneseleninic acid
	related_synonym:	Formula=CH4O2Se; InChI=1S/CH4O2Se/c1-4(2)3/h1H3,(H,2,3); InChIKey=UEQANLFPOFICBH-UHFFFAOYSA-N; Methylseleninate; SMILES=C[Se](O)=O
	xref:	CAS:28274-57-9; KEGG:C18902
	xref_mesh:	MESH:C008493
	xref:	PMID:21500193; PMID:21519842; PMID:21910718; PMID:22095442; PMID:22128327; PMID:22179721; PMID:22348099; PMID:22640261; PMID:22711297; PMID:22975630; PMID:23470450; PMID:23613334; PMID:23995784; PMID:24001829; PMID:24447148; PMID:24515947; Reaxys:1734752; Wikipedia:Methaneseleninic_Acid

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Genes (405)

methylseleninic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions
decreases expression
affects expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of ABCC4 mRNA]
methylselenic acid affects the expression of ABCC4 mRNA

PMID:14617803 PMID:16020662 PMID:18548127

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283

G

acid phosphatase 3

affects expression

methylselenic acid affects the expression of ACP3 mRNA

NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:104,905,586...104,954,236

G

acyl-CoA synthetase long-chain family member 3

affects expression
decreases expression

methylselenic acid affects the expression of ACSL3 mRNA
methylselenic acid results in decreased expression of ACSL3 mRNA

PMID:14617803 PMID:18548127

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627

G

actin alpha 2, smooth muscle

increases expression

methylselenic acid results in increased expression of ACTA2 mRNA

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

actin gamma 2, smooth muscle

increases expression

methylselenic acid results in increased expression of ACTG2 mRNA

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465

G

ADAM metallopeptidase domain 22

increases expression

methylselenic acid results in increased expression of ADAM22 mRNA

NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:25,715,990...25,964,962

G

adducin 3

increases expression

methylselenic acid results in increased expression of ADD3 mRNA

NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:252,147,386...252,255,124

G

adhesion G protein-coupled receptor L3

increases expression

methylselenic acid results in increased expression of ADGRL3 mRNA

NCBI chr14:26,690,891...27,458,132
Ensembl chr14:26,368,277...27,105,860

G

aryl hydrocarbon receptor

increases expression

methylselenic acid results in increased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 12

increases expression

methylselenic acid results in increased expression of AKAP12 mRNA

NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:40,730,123...40,819,886

G

aldo-keto reductase family 1 member B1

increases expression

methylselenic acid results in increased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
decreases response to substance

[methylselenic acid results in decreased phosphorylation of AKT1 protein] which results in increased susceptibility to Doxorubicin; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
AKT1 protein results in decreased susceptibility to methylselenic acid

PMID:15845651 PMID:17339365

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases expression

methylselenic acid results in decreased expression of AKT2 mRNA

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817

G

aminolevulinate dehydratase

increases expression

methylselenic acid results in increased expression of ALAD mRNA

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474

G

ALG3, alpha-1,3- mannosyltransferase

decreases expression

methylselenic acid results in decreased expression of ALG3 mRNA

NCBI chr11:93,804,859...93,810,403
Ensembl chr11:80,300,498...80,307,912

G

ALG8, alpha-1,3-glucosyltransferase

decreases expression

methylselenic acid results in decreased expression of ALG8 mRNA

NCBI chr 1:151,684,344...151,704,310
Ensembl chr 1:151,684,396...151,704,302

G

aminomethyltransferase

increases expression

methylselenic acid results in increased expression of AMT mRNA

NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126

G

ankyrin 2

increases expression

methylselenic acid results in increased expression of ANK2 mRNA

NCBI chr 2:218,052,555...218,628,414
Ensembl chr 2:215,379,680...215,862,923

G

ankyrin 3

decreases expression

methylselenic acid results in decreased expression of ANK3 mRNA

NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,602,786...19,086,300

G

apolipoprotein D

affects expression

methylselenic acid affects the expression of APOD mRNA

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305

G

androgen receptor

affects response to substance
multiple interactions
decreases activity
decreases expression
increases degradation

AR protein affects the susceptibility to methylselenic acid
AR protein inhibits the reaction [methylselenic acid results in decreased expression of ABCC4 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of DHCR24 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of GUCY1A1 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK2 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK3 mRNA]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 promoter]]; Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein]
methylselenic acid results in decreased activity of AR protein
methylselenic acid results in decreased expression of AR mRNA; methylselenic acid results in decreased expression of AR protein
methylselenic acid results in increased degradation of AR mRNA; methylselenic acid results in increased degradation of AR protein

PMID:14617803 PMID:15141018 PMID:16020662 PMID:16648561 PMID:16928829

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

methylselenic acid results in increased expression of ARHGEF2 mRNA

NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:174,062,976...174,118,355

G

ARF like GTPase 4A

increases expression

methylselenic acid results in increased expression of ARL4A mRNA

NCBI chr 6:62,809,287...62,811,297
Ensembl chr 6:57,078,812...57,085,066

G

activating transcription factor 2

multiple interactions

methylselenic acid results in increased phosphorylation of and results in increased activity of ATF2 protein

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 3

affects expression

methylselenic acid affects the expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 5

decreases expression

methylselenic acid results in decreased expression of ATF5 mRNA

PMID:12517777 PMID:18548127

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:95,295,610...95,299,707

G

activating transcription factor 6

multiple interactions

methylselenic acid results in increased cleavage of and results in increased activity of ATF6 protein

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

methylselenic acid results in increased expression of ATP2A2 mRNA

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101

G

ATPase plasma membrane Ca2+ transporting 4

increases expression

methylselenic acid results in increased expression of ATP2B4 mRNA

NCBI chr13:47,708,157...47,807,389
Ensembl chr13:45,156,146...45,255,246

G

aurora kinase A

affects expression
decreases expression

methylselenic acid affects the expression of AURKA mRNA
methylselenic acid results in decreased expression of AURKA mRNA

PMID:12517777 PMID:14617803

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390

G

beta-1,4-galactosyltransferase 1

affects expression

methylselenic acid affects the expression of B4GALT1 mRNA

NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:55,935,615...55,982,461

G

BTB domain and CNC homolog 1

increases expression

methylselenic acid results in increased expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:26,939,480...26,972,447

G

BCL2 associated X, apoptosis regulator

affects expression

methylselenic acid affects the expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

methylselenic acid results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

affects expression

methylselenic acid affects the expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

methylselenic acid results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 11

multiple interactions
increases expression
increases cleavage

BCL2L11 protein affects the susceptibility to [Doxorubicin co-treated with methylselenic acid]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of BCL2L11 protein]
methylselenic acid results in increased expression of BCL2L11 mRNA; methylselenic acid results in increased expression of BCL2L11 protein

PMID:17339365 PMID:18790785 PMID:28161410

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

baculoviral IAP repeat-containing 2

affects expression

methylselenic acid affects the expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

affects expression

methylselenic acid affects the expression of BIRC3 mRNA

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of BIRC5 protein; methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]
methylselenic acid results in decreased expression of BIRC5 mRNA; methylselenic acid results in decreased expression of BIRC5 protein

PMID:12517777 PMID:17876054 PMID:18444175 PMID:18567002

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 4

increases expression

methylselenic acid results in increased expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306

G

BRCA2, DNA repair associated

increases expression

methylselenic acid results in increased expression of BRCA2 mRNA

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

BTG anti-proliferation factor 3

increases expression

methylselenic acid results in increased expression of BTG3 mRNA

NCBI chr11:30,517,068...30,532,981
Ensembl chr11:17,030,160...17,046,170

G

BUB1 mitotic checkpoint serine/threonine kinase B

affects expression

methylselenic acid affects the expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

complement C1q binding protein

decreases expression

methylselenic acid results in decreased expression of C1QBP mRNA

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649

G

cell adhesion molecule 1

affects expression

methylselenic acid affects the expression of CADM1 mRNA

NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:47,847,325...48,182,833

G

calmodulin 1

increases expression

methylselenic acid results in increased expression of CALM1 mRNA

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:119,487,621...119,498,227

G

calcium/calmodulin-dependent protein kinase II gamma

increases expression

methylselenic acid results in increased expression of CAMK2G mRNA

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,504,085...3,563,050

G

calcium/calmodulin-dependent protein kinase IV

increases expression

methylselenic acid results in increased expression of CAMK4 mRNA

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487

G

capping actin protein of muscle Z-line subunit alpha 1

decreases expression

methylselenic acid results in decreased expression of CAPZA1 mRNA

NCBI chr 2:195,008,035...195,053,100
Ensembl chr 2:192,319,702...192,364,480

G

caspase 12

multiple interactions
increases cleavage

HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP12 protein]

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage

methylselenic acid results in increased cleavage of and results in increased activity of CASP3 protein
methylselenic acid results in increased cleavage of CASP3 protein

PMID:19276161 PMID:28161410

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases cleavage

methylselenic acid results in increased cleavage of CASP4 protein

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

increases cleavage
multiple interactions

methylselenic acid results in increased cleavage of CASP7 protein
Acetylcysteine inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; methylselenic acid inhibits the reaction [CASP7 protein binds to HSPA5 protein]; Sodium Selenite inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of CASP7 protein]

PMID:16204082 PMID:18790785 PMID:28161410

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases cleavage

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP8 protein; [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 protein
[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; methylselenic acid results in increased cleavage of CASP8 protein

PMID:18444175 PMID:18790785

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases expression
increases cleavage

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP9 protein; [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein]; methylselenic acid results in increased cleavage of and results in increased activity of CASP9 protein
methylselenic acid results in increased expression of CASP9 mRNA
[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; methylselenic acid results in increased cleavage of CASP9 protein

PMID:12517777 PMID:17339365 PMID:18444175 PMID:18790785 PMID:28161410

Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

increases expression

methylselenic acid results in increased expression of CAST mRNA

NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:3,973,112...4,082,659

G

chromobox 7

increases expression

methylselenic acid results in increased expression of CBX7 mRNA

NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:111,460,656...111,477,973

G

cholecystokinin

increases expression

methylselenic acid results in increased expression of CCK mRNA

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084

G

cyclin A2

decreases expression

methylselenic acid results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

methylselenic acid results in decreased expression of CCNB1 mRNA; methylselenic acid results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

affects expression
multiple interactions
decreases expression

methylselenic acid affects the expression of CCND1 mRNA
[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CCND1 protein; KLF4 protein affects the reaction [methylselenic acid results in decreased expression of CCND1 mRNA]; methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]
methylselenic acid affects the expression of CCND1 protein

PMID:11830524 PMID:12017302 PMID:17847021 PMID:18314491 PMID:18444175

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E2

decreases expression

methylselenic acid results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632

G

CD14 molecule

decreases expression

methylselenic acid results in decreased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261

G

CD44 molecule

decreases expression

methylselenic acid results in decreased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 14B

affects expression

methylselenic acid affects the expression of CDC14B mRNA

NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235

G

cell division cycle 20

affects expression

methylselenic acid affects the expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25A

affects expression
decreases expression

methylselenic acid affects the expression of CDC25A mRNA
methylselenic acid results in decreased expression of CDC25A mRNA; methylselenic acid results in decreased expression of CDC25A protein

PMID:11830524 PMID:14617803

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25C

decreases expression

methylselenic acid results in decreased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 42

decreases expression

methylselenic acid results in decreased expression of CDC42 mRNA

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:149,553,724...149,593,111

G

CDC42 effector protein 3

increases expression

methylselenic acid results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

cell division cycle 6

decreases expression
affects expression

methylselenic acid results in decreased expression of CDC6 mRNA
methylselenic acid affects the expression of CDC6 mRNA

PMID:11830524 PMID:14617803

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011

G

cadherin 15

increases expression

methylselenic acid results in increased expression of CDH15 mRNA

NCBI chr19:67,812,169...67,834,986
Ensembl chr19:50,903,638...50,927,105

G

cadherin 7

increases expression

methylselenic acid results in increased expression of CDH7 mRNA

NCBI chr13:27,186,223...27,336,076
Ensembl chr13:26,672,484...26,819,846

G

cyclin-dependent kinase 1

multiple interactions
decreases expression

HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK1 protein]
methylselenic acid results in decreased expression of CDK1 mRNA; methylselenic acid results in decreased expression of CDK1 protein

PMID:11830524 PMID:12517777 PMID:16205645

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

decreases expression

methylselenic acid results in decreased expression of CDK10 mRNA

NCBI chr19:68,168,040...68,184,923
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase 16

decreases expression

methylselenic acid results in decreased expression of CDK16 mRNA

NCBI chr X:1,492,814...1,504,309
Ensembl chr X:1,492,814...1,504,148

G

cyclin-dependent kinase 18

increases expression

methylselenic acid results in increased expression of CDK18 mRNA

NCBI chr13:46,107,763...46,140,705
Ensembl chr13:43,556,748...43,588,525

G

cyclin dependent kinase 2

multiple interactions
decreases expression

HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK2 protein]; methylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]
methylselenic acid results in decreased expression of CDK2 mRNA; methylselenic acid results in decreased expression of CDK2 protein

PMID:12517777 PMID:16205645 PMID:17847021

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions
decreases expression

methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]
methylselenic acid results in decreased expression of CDK4 mRNA

PMID:11830524 PMID:12517777 PMID:17847021 PMID:18548127

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

increases expression

methylselenic acid results in increased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 6

multiple interactions

methylselenic acid promotes the reaction [CDKN2A protein binds to CDK6 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK6 protein]

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634

G

cyclin dependent kinase like 1

decreases expression

methylselenic acid results in decreased expression of CDKL1 mRNA

NCBI chr 6:93,960,157...94,005,207
Ensembl chr 6:88,224,143...88,270,276

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
affects expression
increases expression

DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; HSPA5 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; methylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in increased expression of and results in decreased degradation of CDKN1A protein
methylselenic acid affects the expression of CDKN1A mRNA
methylselenic acid results in increased expression of CDKN1A mRNA; methylselenic acid results in increased expression of CDKN1A protein
methylselenic acid affects the expression of CDKN1A protein

PMID:12017302 PMID:12517777 PMID:14617803 PMID:16205645 PMID:17847021 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression
affects expression

KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1B mRNA]; methylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]; methylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]
methylselenic acid results in increased expression of CDKN1B mRNA; methylselenic acid results in increased expression of CDKN1B protein
methylselenic acid affects the expression of CDKN1B protein

PMID:12017302 PMID:17847021 PMID:18314491

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

increases expression
affects expression

methylselenic acid results in increased expression of CDKN1C mRNA
methylselenic acid affects the expression of CDKN1C mRNA

PMID:14617803 PMID:18548127

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2A

multiple interactions
increases expression

methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid promotes the reaction [CDKN2A protein binds to CDK6 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein]; methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK6 protein]
methylselenic acid results in increased expression of CDKN2A protein

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

cyclin dependent kinase inhibitor 2D

affects expression
increases expression

methylselenic acid affects the expression of CDKN2D mRNA
methylselenic acid results in increased expression of CDKN2D mRNA

PMID:12517777 PMID:14617803

NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:19,831,866...19,834,674

G

centromere protein A

affects expression

methylselenic acid affects the expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein F

decreases expression

methylselenic acid results in decreased expression of CENPF mRNA

NCBI chr13:103,715,344...103,760,931
Ensembl chr13:101,184,127...101,229,669

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of CFLAR protein

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034

G

chromatin assembly factor 1 subunit A

decreases expression

methylselenic acid results in decreased expression of CHAF1A mRNA

NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654

G

checkpoint kinase 2

increases expression

methylselenic acid results in increased expression of CHEK2 mRNA

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

clusterin

affects expression

methylselenic acid affects the expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315

G

canopy FGF signaling regulator 2

decreases expression

methylselenic acid results in decreased expression of CNPY2 mRNA

NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519

G

collagen type XVI alpha 1 chain

increases expression

methylselenic acid results in increased expression of COL16A1 mRNA

NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825

G

collagen type VI alpha 1 chain

increases expression

methylselenic acid results in increased expression of COL6A1 mRNA

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,957...11,924,597

G

coronin 1A

increases expression

methylselenic acid results in increased expression of CORO1A mRNA

NCBI chr 1:190,726,129...190,731,133
Ensembl chr 1:181,295,562...181,300,534

G

cellular retinoic acid binding protein 2

increases expression

methylselenic acid results in increased expression of CRABP2 mRNA

NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:173,416,857...173,421,379

G

cAMP responsive element binding protein 1

increases expression

methylselenic acid results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 3-like 1

decreases expression

methylselenic acid results in decreased expression of CREB3L1 mRNA

NCBI chr 3:98,408,240...98,449,104
Ensembl chr 3:77,952,540...77,993,456

G

cAMP responsive element binding protein 3-like 4

affects expression

methylselenic acid affects the expression of CREB3L4 mRNA

NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:175,690,335...175,695,932

G

crystallin, alpha B

increases expression

methylselenic acid results in increased expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157

G

cysteine and glycine-rich protein 1

increases expression

methylselenic acid results in increased expression of CSRP1 mRNA

NCBI chr13:49,709,928...49,731,141
Ensembl chr13:47,167,789...47,179,384

G

cathepsin K

increases expression

methylselenic acid results in increased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550

G

cullin 1

increases expression

methylselenic acid results in increased expression of CUL1 mRNA

NCBI chr 4:77,551,781...77,634,210
Ensembl chr 4:76,551,983...76,627,980

G

CYLD lysine 63 deubiquitinase

increases expression

methylselenic acid results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:18,314,019...18,373,658

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of DDIT3 protein]
methylselenic acid results in increased expression of DDIT3 mRNA; methylselenic acid results in increased expression of DDIT3 protein

PMID:11830524 PMID:12517777 PMID:16204082 PMID:16205645 PMID:19276161 More...

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

DEAF1 transcription factor

decreases expression

methylselenic acid results in decreased expression of DEAF1 mRNA

NCBI chr 1:205,831,428...205,865,106
Ensembl chr 1:196,401,857...196,435,541

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of DHCR24 mRNA]

PMID:16020662 PMID:18548127

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137

G

dihydrofolate reductase

decreases expression

methylselenic acid results in decreased expression of DHFR mRNA

NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713

G

DIX domain containing 1

increases expression

methylselenic acid results in increased expression of DIXDC1 mRNA

NCBI chr 8:59,904,218...59,977,595
Ensembl chr 8:51,007,838...51,081,090

G

dyskerin pseudouridine synthase 1

decreases expression

methylselenic acid results in decreased expression of DKC1 mRNA

NCBI chr X:157,751,651...157,757,796

G

DLC1 Rho GTPase activating protein

increases expression

methylselenic acid results in increased expression of DLC1 mRNA

NCBI chr16:61,954,177...62,374,819
Ensembl chr16:55,291,584...55,671,439

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

methylselenic acid results in increased expression of DNAJB5 mRNA

NCBI chr 5:61,972,637...61,981,887
Ensembl chr 5:57,176,845...57,185,490

G

DnaJ heat shock protein family (Hsp40) member B9

affects expression

methylselenic acid affects the expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:61,269,913...61,275,063

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

methylselenic acid results in decreased expression of DNPH1 mRNA

NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:14,481,066...14,484,022

G

dihydropyrimidine dehydrogenase

increases expression

methylselenic acid results in increased expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982

G

dihydropyrimidinase-like 2

increases expression

methylselenic acid results in increased expression of DPYSL2 mRNA

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:41,005,551...41,111,829

G

dystrobrevin, alpha

increases expression

methylselenic acid results in increased expression of DTNA mRNA

NCBI chr18:14,862,801...15,218,993
Ensembl chr18:14,587,852...14,944,261

G

deoxythymidylate kinase

decreases expression

methylselenic acid results in decreased expression of DTYMK mRNA

NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:94,315,552...94,324,870

G

dual specificity phosphatase 10

increases expression

methylselenic acid results in increased expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716

G

dishevelled segment polarity protein 3

increases expression

methylselenic acid results in increased expression of DVL3 mRNA

NCBI chr11:93,869,834...93,887,013
Ensembl chr11:80,366,117...80,382,462

G

dynein cytoplasmic 1 intermediate chain 1

increases expression

methylselenic acid results in increased expression of DYNC1I1 mRNA

NCBI chr 4:34,819,313...35,132,647
Ensembl chr 4:33,852,927...34,166,149

G

E2F transcription factor 1

affects expression
decreases expression
multiple interactions

methylselenic acid affects the expression of E2F1 mRNA
methylselenic acid results in decreased expression of E2F1 mRNA; methylselenic acid results in decreased expression of E2F1 protein
methylselenic acid promotes the reaction [E2F1 protein binds to RB1 protein]

PMID:11830524 PMID:14617803 PMID:17847021

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 5

decreases expression

methylselenic acid results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

enoyl-CoA delta isomerase 1

decreases expression

methylselenic acid results in decreased expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,456,563...13,470,061

G

extracellular matrix protein 2

increases expression

methylselenic acid results in increased expression of ECM2 mRNA

NCBI chr17:15,326,359...15,358,938
Ensembl chr17:15,120,196...15,152,516

G

endothelin receptor type A

increases expression

methylselenic acid results in increased expression of EDNRA mRNA

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

increases expression

methylselenic acid results in increased expression of EDNRB mRNA

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115

G

EGF containing fibulin extracellular matrix protein 2

increases expression

methylselenic acid results in increased expression of EFEMP2 mRNA

NCBI chr 1:212,211,057...212,218,739
Ensembl chr 1:202,781,665...202,789,414

G

early growth response 1

increases expression

methylselenic acid results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2A

multiple interactions
increases phosphorylation

HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2A protein]

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein]; methylselenic acid results in increased phosphorylation of and results in increased activity of EIF2AK3 protein

PMID:16204082 PMID:16205645

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 4, gamma 2

decreases expression

methylselenic acid results in decreased expression of EIF4G2 mRNA

NCBI chr 1:174,616,102...174,628,252
Ensembl chr 1:165,181,434...165,193,588

G

E74 like ETS transcription factor 3

increases expression
affects expression

methylselenic acid results in increased expression of ELF3 mRNA
methylselenic acid affects the expression of ELF3 mRNA

PMID:12517777 PMID:14617803

NCBI chr13:49,242,265...49,247,102
Ensembl chr13:46,690,466...46,695,481

G

enolase 2

increases expression

methylselenic acid results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980

G

erythrocyte membrane protein band 4.1-like 2

increases expression

methylselenic acid results in increased expression of EPB41L2 mRNA

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

EGFR pathway substrate 8, signaling adaptor

increases expression

methylselenic acid results in increased expression of EPS8 mRNA

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:170,388,378...170,486,873

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

methylselenic acid results in increased expression of ERCC1 mRNA

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963

G

estrogen receptor 1

multiple interactions
decreases expression

[methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 mRNA; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 protein; methylselenic acid inhibits the reaction [Estradiol binds to ESR1 protein]; methylselenic acid results in decreased expression of and results in decreased activity of ESR1 protein
methylselenic acid results in decreased expression of ESR1 mRNA; methylselenic acid results in decreased expression of ESR1 protein

PMID:15833885 PMID:16093440 PMID:16155795

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression
affects expression

methylselenic acid results in increased expression of ESR2 mRNA
methylselenic acid affects the expression of ESR2 mRNA

PMID:15833885 PMID:16928829

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919

G

ETS variant transcription factor 5

increases expression

methylselenic acid results in increased expression of ETV5 mRNA

NCBI chr11:92,113,171...92,170,758
Ensembl chr11:78,608,710...78,666,215

G

ETS variant transcription factor 6

increases expression

methylselenic acid results in increased expression of ETV6 mRNA

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:166,847,686...167,084,992

G

exostosin glycosyltransferase 1

increases expression

methylselenic acid results in increased expression of EXT1 mRNA

NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:84,375,784...84,655,357

G

family with sequence similarity 107, member A

increases expression

methylselenic acid results in increased expression of FAM107A mRNA

NCBI chr15:19,038,726...19,060,644
Ensembl chr15:16,607,205...16,630,396

G

F-box and leucine-rich repeat protein 8

increases expression

methylselenic acid results in increased expression of FBXL8 mRNA

NCBI chr19:33,142,705...33,147,266
Ensembl chr19:33,142,715...33,147,262

G

FERM domain containing kindlin 2

increases expression

methylselenic acid results in increased expression of FERMT2 mRNA

NCBI chr15:21,162,603...21,257,995
Ensembl chr15:18,682,927...18,751,811

G

fasciculation and elongation protein zeta 1

increases expression

methylselenic acid results in increased expression of FEZ1 mRNA

NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683

G

fibroblast growth factor 2

decreases expression

methylselenic acid results in decreased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

four and a half LIM domains 2

increases expression

methylselenic acid results in increased expression of FHL2 mRNA

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:45,388,981...45,431,192

G

FKBP prolyl isomerase 4

decreases expression

methylselenic acid results in decreased expression of FKBP4 mRNA

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:161,703,379...161,711,833

G

FKBP prolyl isomerase 5

affects expression

methylselenic acid affects the expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,457,216...6,541,674

G

filamin C

increases expression

methylselenic acid results in increased expression of FLNC mRNA

NCBI chr 4:58,999,445...59,027,240
Ensembl chr 4:58,034,189...58,061,844

G

fibronectin 1

affects expression

methylselenic acid affects the expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678

G

formin binding protein 1

increases expression

methylselenic acid results in increased expression of FNBP1 mRNA

NCBI chr 3:34,706,814...34,826,770
Ensembl chr 3:14,309,640...14,424,881

G

forkhead box A1

decreases expression

methylselenic acid results in decreased expression of FOXA1 mRNA

PMID:12517777 PMID:18548127

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box O3

multiple interactions

methylselenic acid results in decreased phosphorylation of and results in increased activity of FOXO3 protein

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

FYN proto-oncogene, Src family tyrosine kinase

increases expression

methylselenic acid results in increased expression of FYN mRNA

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911

G

GABA type A receptor associated protein like 1

increases expression

methylselenic acid results in increased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:162,980,249...162,989,450

G

growth arrest and DNA-damage-inducible, alpha

increases expression

methylselenic acid results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

methylselenic acid results in decreased expression of GALNT1 mRNA

NCBI chr18:15,763,697...15,843,598
Ensembl chr18:15,489,020...15,568,245

G

growth arrest-specific 1

increases expression

methylselenic acid results in increased expression of GAS1 mRNA

NCBI chr17:4,487,716...4,490,701

G

glutamine amidotransferase class 1 domain containing 3A

decreases expression

methylselenic acid results in decreased expression of GATD3 mRNA

NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885

G

guanylate binding protein 2

increases expression

methylselenic acid results in increased expression of GBP2 mRNA

NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:231,332,284...231,348,571

G

gap junction protein, alpha 1

increases expression

methylselenic acid results in increased expression of GJA1 mRNA

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

G protein-coupled receptor 161

increases expression

methylselenic acid results in increased expression of GPR161 mRNA

NCBI chr13:77,578,257...77,623,661
Ensembl chr13:77,577,739...77,619,613

G

G protein-coupled receptor 37

increases expression

methylselenic acid results in increased expression of GPR37 mRNA

NCBI chr 4:55,104,355...55,126,420
Ensembl chr 4:54,138,870...54,161,001

G

G protein-coupled receptor kinase 5

increases expression

methylselenic acid results in increased expression of GRK5 mRNA

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:260,028,242...260,218,701

G

glycogen synthase kinase 3 beta

multiple interactions
decreases phosphorylation

methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]
methylselenic acid results in decreased phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

methylselenic acid results in increased expression of GSN mRNA

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402

G

general transcription factor IIIC subunit 1

decreases expression

methylselenic acid results in decreased expression of GTF3C1 mRNA

NCBI chr 1:189,634,645...189,700,848
Ensembl chr 1:180,203,995...180,270,201

G

guanylate cyclase 1 soluble subunit alpha 1

affects expression
multiple interactions
decreases expression

methylselenic acid affects the expression of GUCY1A1 mRNA
AR protein inhibits the reaction [methylselenic acid results in decreased expression of GUCY1A1 mRNA]

PMID:14617803 PMID:16020662 PMID:18548127

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:167,418,640...167,481,671

G

H1.0 linker histone

affects expression

methylselenic acid affects the expression of H1-0 mRNA

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:110,592,208...110,594,694

G

H2A clustered histone 18

decreases expression

methylselenic acid results in decreased expression of H2AC18 mRNA

NCBI chr 2:186,497,271...186,497,865

G

hyaluronan binding protein 4

increases expression

methylselenic acid results in increased expression of HABP4 mRNA

NCBI chr17:934,931...957,604
Ensembl chr17:935,654...957,565

G

3-hydroxyacyl-CoA dehydratase 2

decreases expression

methylselenic acid results in decreased expression of HACD2 mRNA

NCBI chr11:79,175,470...79,268,975
Ensembl chr11:65,670,281...65,762,889

G

hephaestin

increases expression

methylselenic acid results in increased expression of HEPH mRNA

NCBI chr X:65,160,628...65,412,457
Ensembl chr X:61,296,345...61,402,980

G

histone cluster 1 H2A family member F

decreases expression

methylselenic acid results in decreased expression of H2AC8 mRNA

NCBI chr17:41,807,261...41,807,653
Ensembl chr17:41,379,404...41,379,796

G

high mobility group nucleosomal binding domain 2, pseudogene 3

increases expression

methylselenic acid results in increased expression of HMGN4 mRNA

NCBI chr 3:99,990,743...99,991,003
Ensembl chr 3:99,990,743...99,991,003

G

heterogeneous nuclear ribonucleoprotein A/B

decreases expression

methylselenic acid results in decreased expression of HNRNPAB mRNA

NCBI chr10:36,358,004...36,363,898
Ensembl chr10:35,857,041...35,863,344

G

homeobox A9

decreases expression

methylselenic acid results in decreased expression of HOXA9 mRNA

NCBI chr 4:82,653,847...82,659,958
Ensembl chr 4:81,323,382...81,326,358

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homeobox D8

increases expression

methylselenic acid results in increased expression of HOXD8 mRNA

NCBI chr 3:80,015,223...80,017,789
Ensembl chr 3:59,607,996...59,610,361

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15-hydroxyprostaglandin dehydrogenase

increases expression

methylselenic acid results in increased expression of HPGD mRNA; methylselenic acid results in increased expression of HPGD protein

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:33,986,266...34,024,228

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hematopoietic prostaglandin D synthase

increases expression

methylselenic acid results in increased expression of HPGDS mRNA

NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:94,373,342...94,397,883

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heat shock protein 90 beta family member 1

increases expression
multiple interactions

methylselenic acid results in increased expression of HSP90B1 protein
HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSP90B1 protein]

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788

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heat shock protein family A (Hsp70) member 4 like

increases expression

methylselenic acid results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:123,740,384...123,793,084

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heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK1 protein]; HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK2 protein]; HSPA5 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP12 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of PARP1 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of DDIT3 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSP90B1 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSPA5 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2A protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein]; methylselenic acid inhibits the reaction [CASP7 protein binds to HSPA5 protein]
methylselenic acid results in increased expression of HSPA5 mRNA; methylselenic acid results in increased expression of HSPA5 protein

PMID:16204082 PMID:16205645 PMID:28161410

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

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inhibitor of DNA binding 1

decreases expression

methylselenic acid results in decreased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

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inhibitor of DNA binding 2

affects expression

methylselenic acid affects the expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

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inhibitor of DNA binding 3

decreases expression
increases expression

methylselenic acid results in decreased expression of ID3 mRNA
methylselenic acid results in increased expression of ID3 mRNA

PMID:12517777 PMID:18548127

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349

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iduronate 2-sulfatase

increases expression

methylselenic acid results in increased expression of IDS mRNA

NCBI chr X:154,070,781...154,093,681
Ensembl chr X:149,025,976...149,046,663

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interferon-related developmental regulator 2

decreases expression

methylselenic acid results in decreased expression of IFRD2 mRNA

NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:108,260,969...108,266,194

G

insulin-like growth factor 1

increases expression

methylselenic acid results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

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immunoglobulin superfamily, member 3

affects expression

methylselenic acid affects the expression of IGSF3 mRNA

NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:188,811,380...188,899,645

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inhibitor of growth family, member 1

affects expression

methylselenic acid affects the expression of ING1 mRNA

NCBI chr16:84,639,378...84,649,498
Ensembl chr16:77,937,279...77,946,264

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inositol polyphosphate-4-phosphatase type II B

affects expression

methylselenic acid affects the expression of INPP4B mRNA

NCBI chr19:42,824,710...43,575,039
Ensembl chr19:25,925,358...26,280,634

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importin 8

increases expression

methylselenic acid results in increased expression of IPO8 mRNA

NCBI chr 4:183,460,583...183,529,259
Ensembl chr 4:181,729,220...181,793,161

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interferon regulatory factor 1

affects expression

methylselenic acid affects the expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166

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integrin subunit alpha 3

increases expression

methylselenic acid results in increased expression of ITGA3 mRNA

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:79,990,161...80,022,118

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integrin subunit beta 1

decreases expression

methylselenic acid results in decreased expression of ITGB1 mRNA

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195

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integrin subunit beta 3 binding protein

decreases expression

methylselenic acid results in decreased expression of ITGB3BP mRNA

NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704

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integrin subunit beta 4

decreases expression

methylselenic acid results in decreased expression of ITGB4 mRNA

NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,206,665...101,243,012

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integrin subunit beta 5

decreases expression

methylselenic acid results in decreased expression of ITGB5 mRNA

NCBI chr11:80,333,588...80,449,373
Ensembl chr11:66,829,285...66,944,472

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inositol 1,4,5-trisphosphate receptor, type 1

increases expression

methylselenic acid results in increased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491

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Janus kinase 1

affects expression
increases expression

methylselenic acid affects the expression of JAK1 mRNA
methylselenic acid results in increased expression of JAK1 mRNA

PMID:14617803 PMID:18548127

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

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Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
affects expression

methylselenic acid results in decreased expression of JUN protein
methylselenic acid affects the expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

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JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

methylselenic acid results in decreased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

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potassium voltage-gated channel subfamily A regulatory beta subunit 1

increases expression

methylselenic acid results in increased expression of KCNAB1 mRNA

NCBI chr 2:151,446,975...151,913,636
Ensembl chr 2:149,137,041...149,603,534

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potassium voltage-gated channel subfamily H member 2

increases expression

methylselenic acid results in increased expression of KCNH2 mRNA

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

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potassium inwardly-rectifying channel, subfamily J, member 8

increases expression

methylselenic acid results in increased expression of KCNJ8 mRNA

NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:175,508,912...175,515,603

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KDEL endoplasmic reticulum protein retention receptor 2

decreases expression

methylselenic acid results in decreased expression of KDELR2 mRNA

NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153

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kinesin family member 11

decreases expression

methylselenic acid results in decreased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:235,124,316...235,176,766

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kinesin family member 20B

decreases expression

methylselenic acid results in decreased expression of KIF20B mRNA

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:232,428,371...232,483,787

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KLF transcription factor 4

multiple interactions
affects expression
increases activity
increases expression

KLF4 protein affects the reaction [methylselenic acid results in decreased expression of CCND1 mRNA]; KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]; KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1B mRNA]
methylselenic acid affects the expression of KLF4 mRNA
methylselenic acid results in increased activity of KLF4 protein
methylselenic acid results in increased expression of KLF4 mRNA

PMID:14617803 PMID:18314491

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602

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kelch-like family member 2

affects expression

methylselenic acid affects the expression of KLHL2 mRNA

NCBI chr16:29,627,171...29,739,782
Ensembl chr16:24,860,667...24,973,341

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kallikrein 1-related peptidase C10

multiple interactions
decreases secretion
affects expression
decreases expression

AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK3 mRNA]; methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]; methylselenic acid inhibits the reaction [mibolerone results in increased expression of KLK3 mRNA]; methylselenic acid results in increased degradation of and results in decreased expression of and results in decreased secretion of KLK3 protein
methylselenic acid results in decreased secretion of KLK3 protein
methylselenic acid affects the expression of KLK3 mRNA
methylselenic acid results in decreased expression of KLK3 mRNA; methylselenic acid results in decreased expression of KLK3 protein

PMID:14617803 PMID:15141018 PMID:16020662 PMID:16648561 PMID:16928829 More...

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052

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keratin 15

increases expression

methylselenic acid results in increased expression of KRT15 mRNA

NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,066,802...85,171,799

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keratin 20

increases expression

methylselenic acid results in increased expression of KRT20 mRNA

NCBI chr10:84,880,952...84,890,285
Ensembl chr10:84,384,802...84,394,107

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L antigen family, member 3

decreases expression

methylselenic acid results in decreased expression of LAGE3 mRNA

NCBI chr X:157,289,497...157,290,920
Ensembl chr X:152,138,218...152,139,632

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laminin subunit alpha 4

increases expression

methylselenic acid results in increased expression of LAMA4 mRNA

NCBI chr20:43,946,898...44,087,972
Ensembl chr20:42,392,268...42,533,347

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laminin subunit beta 3

increases expression

methylselenic acid results in increased expression of LAMB3 mRNA

NCBI chr13:107,362,514...107,404,081
Ensembl chr13:104,833,873...104,875,405

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lamin B2

decreases expression

methylselenic acid results in decreased expression of LMNB2 mRNA

NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665

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lysophospholipase 1

decreases expression

methylselenic acid results in decreased expression of LYPLA1 mRNA

NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746

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macrophage erythroblast attacher, E3 ubiquitin ligase

decreases expression

methylselenic acid results in decreased expression of MAEA mRNA

NCBI chr14:81,581,784...81,615,246
Ensembl chr14:77,357,264...77,390,671

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MAF bZIP transcription factor

increases expression

methylselenic acid results in increased expression of MAF mRNA

NCBI chr19:60,259,200...60,622,145
Ensembl chr19:43,360,342...43,712,365

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microtubule-associated protein 1B

affects expression
increases expression

methylselenic acid affects the expression of MAP1B mRNA
methylselenic acid results in increased expression of MAP1B mRNA

PMID:14617803 PMID:18548127

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:30,817,261...30,910,317

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mitogen activated protein kinase kinase 1

decreases expression
increases expression

methylselenic acid results in decreased expression of MAP2K1 mRNA
methylselenic acid results in increased expression of MAP2K1 mRNA

PMID:11830524 PMID:12517777

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

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mitogen activated protein kinase kinase 5

increases expression

methylselenic acid results in increased expression of MAP2K5 mRNA

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:63,625,221...63,851,983

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mitogen activated protein kinase 1

increases phosphorylation

methylselenic acid results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

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mitogen activated protein kinase 3

increases expression
increases phosphorylation

methylselenic acid results in increased expression of MAPK3 mRNA
methylselenic acid results in increased phosphorylation of MAPK3 protein

PMID:11830524 PMID:15845651

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

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mitogen-activated protein kinase 8

increases expression

methylselenic acid results in increased expression of MAPK8 mRNA

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

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mitogen-activated protein kinase 9

decreases expression

methylselenic acid results in decreased expression of MAPK9 mRNA

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

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microtubule-associated protein, RP/EB family, member 2

increases expression

methylselenic acid results in increased expression of MAPRE2 mRNA

NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,029,041...15,168,044

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microtubule-associated protein tau

decreases expression

methylselenic acid results in decreased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129

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MYC associated zinc finger protein

decreases expression

methylselenic acid results in decreased expression of MAZ mRNA

NCBI chr 1:191,060,271...191,065,722
Ensembl chr 1:181,629,729...181,650,408

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muscleblind-like splicing regulator 2

increases expression

methylselenic acid results in increased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:97,385,244...97,542,937

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methylcrotonyl-CoA carboxylase subunit 2

decreases expression

methylselenic acid results in decreased expression of MCCC2 mRNA

NCBI chr 2:33,039,044...33,110,092
Ensembl chr 2:31,304,932...31,375,972

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minichromosome maintenance complex component 2

affects expression

methylselenic acid affects the expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:121,346,434...121,360,847

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minichromosome maintenance complex component 3

decreases expression

methylselenic acid results in decreased expression of MCM3 mRNA

NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:23,219,169...23,237,314

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minichromosome maintenance complex component 5

decreases expression

methylselenic acid results in decreased expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,483,066...13,504,389

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minichromosome maintenance complex component 6

decreases expression
affects expression

methylselenic acid results in decreased expression of MCM6 mRNA
methylselenic acid affects the expression of MCM6 mRNA

PMID:12517777 PMID:14617803

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

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minichromosome maintenance complex component 7

decreases expression

methylselenic acid results in decreased expression of MCM7 mRNA

NCBI chr12:22,155,921...22,163,320
Ensembl chr12:17,042,212...17,050,063

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malic enzyme 1

increases expression

methylselenic acid results in increased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304

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myocyte enhancer factor 2C

increases expression

methylselenic acid results in increased expression of MEF2C mRNA

NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880

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menin 1

affects expression

methylselenic acid affects the expression of MEN1 mRNA

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:203,639,000...203,644,871

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mitochondrial calcium uptake 2

decreases expression

methylselenic acid results in decreased expression of MICU2 mRNA

NCBI chr15:36,180,413...36,262,429
Ensembl chr15:32,064,875...32,147,094

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melanocyte inducing transcription factor

increases expression

methylselenic acid results in increased expression of MITF mRNA

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145

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marker of proliferation Ki-67

decreases expression

methylselenic acid results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

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mitochondrial ribosomal protein L19

decreases expression

methylselenic acid results in decreased expression of MRPL19 mRNA

NCBI chr 4:116,079,654...116,083,883
Ensembl chr 4:114,521,824...114,526,053

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max dimerization protein 1

affects expression

methylselenic acid affects the expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

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MAX interactor 1, dimerization protein

increases expression

methylselenic acid results in increased expression of MXI1 mRNA

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:252,323,303...252,383,681

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MYB proto-oncogene like 2

decreases expression

methylselenic acid results in decreased expression of MYBL2 mRNA

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708

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MYC proto-oncogene, bHLH transcription factor

affects expression
multiple interactions

methylselenic acid affects the expression of MYC mRNA
methylselenic acid inhibits the reaction [afimoxifene results in increased expression of MYC mRNA]; methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]

PMID:14617803 PMID:15833885 PMID:16093440 PMID:16155795

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

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myosin light chain 9

increases expression

methylselenic acid results in increased expression of MYL9 mRNA

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333

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myosin X

decreases expression

methylselenic acid results in decreased expression of MYO10 mRNA

NCBI chr 2:77,831,532...78,036,137
Ensembl chr 2:76,100,987...76,303,030

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myosin VIIA and Rab interacting protein

decreases expression

methylselenic acid results in decreased expression of MYRIP mRNA

NCBI chr 8:128,895,371...129,062,420
Ensembl chr 8:120,017,524...120,183,833

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N-acylethanolamine acid amidase

decreases expression

methylselenic acid results in decreased expression of NAAA mRNA

NCBI chr14:15,777,306...15,796,411
Ensembl chr14:15,777,306...15,796,410

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nuclear receptor coactivator 1

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:27,232,611...27,475,664

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nuclear receptor coactivator 2

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]

NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451

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nuclear receptor co-repressor 1

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR1 protein binds to KLK3 promoter]]

NCBI chr10:47,498,852...47,641,612
Ensembl chr10:46,999,536...47,141,032

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nuclear receptor co-repressor 2

multiple interactions

methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]

NCBI chr12:37,127,736...37,289,612
Ensembl chr12:31,466,412...31,628,319

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N-myc downstream regulated 1

affects expression

methylselenic acid affects the expression of NDRG1 mRNA

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880

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nebulette

increases expression

methylselenic acid results in increased expression of NEBL mRNA

NCBI chr17:85,022,953...85,374,848
Ensembl chr17:80,118,543...80,466,210

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nuclear factor, interleukin 3 regulated

affects expression

methylselenic acid affects the expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

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nuclear factor kappa B subunit 1

decreases expression

methylselenic acid results in decreased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

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NK3 homeobox 1

affects expression

methylselenic acid affects the expression of NKX3-1 mRNA

NCBI chr15:50,883,661...50,886,253
Ensembl chr15:44,473,851...44,476,441

G

NME/NM23 nucleoside diphosphate kinase 1

decreases expression

methylselenic acid results in decreased expression of NME1 mRNA

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408

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NME/NM23 nucleoside diphosphate kinase 4

decreases expression

methylselenic acid results in decreased expression of NME4 mRNA

NCBI chr10:15,619,106...15,622,961
Ensembl chr10:15,002,926...15,118,479

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N-myc (and STAT) interactor

decreases expression

methylselenic acid results in decreased expression of NMI mRNA

NCBI chr 3:56,824,778...56,848,891
Ensembl chr 3:36,415,607...36,439,498

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NAD(P)H quinone dehydrogenase 1

increases activity

methylselenic acid results in increased activity of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

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nuclear receptor subfamily 3, group C, member 1

affects expression

methylselenic acid affects the expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

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ornithine aminotransferase

increases expression

methylselenic acid results in increased expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682

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olfactomedin-like 2A

increases expression

methylselenic acid results in increased expression of OLFML2A mRNA

NCBI chr 3:43,098,299...43,127,621
Ensembl chr 3:22,688,598...22,717,909

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optineurin

increases expression

methylselenic acid results in increased expression of OPTN mRNA

NCBI chr17:78,118,847...78,169,543
Ensembl chr17:73,209,575...73,260,251

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paralemmin A kinase anchor protein

increases expression

methylselenic acid results in increased expression of PALM2AKAP2 mRNA

NCBI chr 5:72,536,986...72,648,524
NCBI chr 5:72,313,646...72,450,645
Ensembl chr 5:72,181,718...72,648,524

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poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of PARP1 protein; [Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of PARP1 protein]; SB 216763 inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]

PMID:15845651 PMID:16204082 PMID:17339365 PMID:18444175 PMID:19276161 More...

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

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POZ (BTB) and AT hook containing zinc finger 1

decreases expression

methylselenic acid results in decreased expression of PATZ1 mRNA

NCBI chr14:82,378,226...82,396,679
Ensembl chr14:78,152,516...78,173,032

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PAX interacting protein 1

decreases expression

methylselenic acid results in decreased expression of PAXIP1 mRNA

NCBI chr 4:8,258,930...8,310,490
Ensembl chr 4:7,525,004...7,576,548

G

PBX homeobox 1

increases expression

methylselenic acid results in increased expression of PBX1 mRNA

NCBI chr13:82,811,664...83,121,447
Ensembl chr13:80,278,770...80,588,594

G

pterin-4 alpha-carbinolamine dehydratase 1

decreases expression

methylselenic acid results in decreased expression of PCBD1 mRNA

NCBI chr20:29,573,362...29,587,181
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292

G

proliferating cell nuclear antigen

affects expression
decreases expression

methylselenic acid affects the expression of PCNA mRNA
methylselenic acid results in decreased expression of PCNA mRNA

PMID:11830524 PMID:12517777 PMID:14617803

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

paternally expressed 3

affects expression

methylselenic acid affects the expression of PEG3 mRNA

NCBI chr 1:67,097,874...67,124,692
Ensembl chr 1:67,097,904...67,124,671

G

prefoldin subunit 5

decreases expression

methylselenic acid results in decreased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

post-GPI attachment to proteins 2

decreases expression

methylselenic acid results in decreased expression of PGAP2 mRNA

NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:156,591,615...156,618,114

G

phosphoglucomutase 5

increases expression

methylselenic acid results in increased expression of PGM5 mRNA

NCBI chr 1:231,752,052...231,939,812
Ensembl chr 1:222,325,643...222,513,437

G

progesterone receptor

affects expression

methylselenic acid affects the expression of PGR mRNA

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344

G

praja ring finger ubiquitin ligase 2

increases expression

methylselenic acid results in increased expression of PJA2 mRNA

NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:103,956,678...104,006,783

G

phospholipase A2 group 4A

increases expression

methylselenic acid results in increased expression of PLA2G4A mRNA

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266

G

phospholipase C, beta 4

increases expression

methylselenic acid results in increased expression of PLCB4 mRNA

NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:122,953,196...123,322,392

G

polo-like kinase 1

decreases expression
affects expression

methylselenic acid results in decreased expression of PLK1 mRNA
methylselenic acid affects the expression of PLK1 mRNA

PMID:11830524 PMID:14617803

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400

G

PMS1 homolog 2, mismatch repair system component

increases expression

methylselenic acid results in increased expression of PMS2 mRNA

NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

methylselenic acid results in decreased expression of POLA1 mRNA

NCBI chr X:62,028,475...62,342,455
Ensembl chr X:58,034,619...58,348,536

G

RNA polymerase II, I and III subunit H

decreases expression

methylselenic acid results in decreased expression of POLR2H mRNA

NCBI chr11:93,696,423...93,701,902
Ensembl chr11:80,192,032...80,197,515
Ensembl chr10:80,192,032...80,197,515

G

PTPRF interacting protein alpha 1

affects expression

methylselenic acid affects the expression of PPFIA1 mRNA

NCBI chr 1:199,641,277...199,718,371
Ensembl chr 1:199,641,277...199,717,277

G

peptidylprolyl isomerase like 2

decreases expression

methylselenic acid results in decreased expression of PPIL2 mRNA

NCBI chr11:97,401,944...97,424,581
Ensembl chr11:83,897,764...83,922,144

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

increases expression

methylselenic acid results in increased expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:9,655,765...9,707,974

G

protein phosphatase 1, regulatory subunit 15A

increases expression

methylselenic acid results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171

G

protein kinase cAMP-dependent type II regulatory subunit beta

increases expression

methylselenic acid results in increased expression of PRKAR2B mRNA

NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:48,563,662...48,653,933

G

protein kinase C, alpha

increases expression

methylselenic acid results in increased expression of PRKCA mRNA

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

increases expression

methylselenic acid results in increased expression of PRKCB mRNA

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536

G

prion protein

increases expression

methylselenic acid results in increased expression of PRNP mRNA

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937

G

phosphatase and tensin homolog

increases expression

methylselenic acid results in increased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E synthase

decreases expression

methylselenic acid results in decreased expression of PTGES mRNA

PMID:11830524 PMID:21669866

NCBI chr 3:34,575,643...34,586,987

G

QKI, KH domain containing RNA binding

increases expression

methylselenic acid results in increased expression of QKI mRNA

NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:50,387,698...50,498,831

G

RAB28, member RAS oncogene family

increases expression

methylselenic acid results in increased expression of RAB28 mRNA

NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967

G

RAB31, member RAS oncogene family

increases expression
affects expression

methylselenic acid results in increased expression of RAB31 mRNA
methylselenic acid affects the expression of RAB31 mRNA

PMID:12517777 PMID:14617803 PMID:18548127

NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:105,246,709...105,381,253

G

Rab acceptor 1

decreases expression

methylselenic acid results in decreased expression of RABAC1 mRNA

NCBI chr 1:89,691,884...89,695,017
Ensembl chr 1:80,564,033...80,567,163

G

RAD9 checkpoint clamp component A

increases expression

methylselenic acid results in increased expression of RAD9A mRNA

NCBI chr 1:210,917,970...210,983,038
Ensembl chr 1:201,487,136...201,553,608

G

ral guanine nucleotide dissociation stimulator like 1

increases expression

methylselenic acid results in increased expression of RGL1 mRNA

NCBI chr13:67,184,402...67,454,019
Ensembl chr13:64,635,246...64,904,191

G

Rap guanine nucleotide exchange factor 4

increases expression

methylselenic acid results in increased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:56,809,270...57,102,316

G

RB transcriptional corepressor 1

multiple interactions

methylselenic acid promotes the reaction [E2F1 protein binds to RB1 protein]; methylselenic acid results in decreased phosphorylation of and results in increased expression of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

retinol dehydrogenase 11

affects expression

methylselenic acid affects the expression of RDH11 mRNA

NCBI chr 6:103,712,373...103,728,247
Ensembl chr 6:97,979,378...97,995,252

G

receptor accessory protein 1

increases expression

methylselenic acid results in increased expression of REEP1 mRNA

NCBI chr 4:105,303,974...105,420,611
Ensembl chr 4:103,745,633...103,862,338

G

replication factor C subunit 5

decreases expression

methylselenic acid results in decreased expression of RFC5 mRNA

NCBI chr12:44,868,322...44,877,879
Ensembl chr12:39,207,484...39,217,312

G

regulator of G-protein signaling 10

increases expression

methylselenic acid results in increased expression of RGS10 mRNA

NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697

G

ras homolog family member B

affects expression

methylselenic acid affects the expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108

G

regulating synaptic membrane exocytosis 3

increases expression

methylselenic acid results in increased expression of RIMS3 mRNA

NCBI chr 5:139,714,302...139,754,145
Ensembl chr 5:134,435,829...134,640,489

G

Rho family GTPase 3

increases expression

methylselenic acid results in increased expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327

G

replication protein A2

decreases expression

methylselenic acid results in decreased expression of RPA2 mRNA

NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:144,976,748...144,987,350

G

ribose 5-phosphate isomerase A

decreases expression

methylselenic acid results in decreased expression of RPIA mRNA

NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355

G

ribosomal protein L27A

decreases expression

methylselenic acid results in decreased expression of RPL27A mRNA

NCBI chr 1:163,539,732...163,542,771

G

ribosomal protein SA

decreases expression

methylselenic acid results in decreased expression of RPSA mRNA

NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase catalytic subunit M1

affects expression

methylselenic acid affects the expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

affects expression

methylselenic acid affects the expression of RRM2 mRNA

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

ribitol xylosyltransferase 1

decreases expression

methylselenic acid results in decreased expression of RXYLT1 mRNA

NCBI chr 7:57,770,841...57,782,695
Ensembl chr 7:57,770,842...57,782,657

G

S100 calcium-binding protein A4

increases expression

methylselenic acid results in increased expression of S100A4 mRNA

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254

G

sterile alpha motif domain containing 4A

increases expression

methylselenic acid results in increased expression of SAMD4 mRNA

NCBI chr15:22,616,200...22,831,872
Ensembl chr15:20,134,377...20,348,380

G

spermidine/spermine N1-acetyl transferase 1

affects expression

methylselenic acid affects the expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:40,157,046...40,196,813

G

stearoyl-CoA desaturase

affects expression

methylselenic acid affects the expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

syndecan 2

increases expression

methylselenic acid results in increased expression of SDC2 mRNA

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081

G

SEC24 homolog D, COPII coat complex component

affects expression

methylselenic acid affects the expression of SEC24D mRNA

NCBI chr 2:214,103,138...214,211,155
Ensembl chr 2:211,418,623...211,526,587

G

semaphorin 5A

increases expression

methylselenic acid results in increased expression of SEMA5A mRNA

NCBI chr 2:85,020,724...85,451,938
Ensembl chr 2:83,309,843...83,741,084

G

serpin family B member 5

increases expression
affects expression

methylselenic acid results in increased expression of SERPINB5 mRNA
methylselenic acid affects the expression of SERPINB5 mRNA

PMID:14617803 PMID:18548127

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:22,985,557...23,005,756

G

serpin family B member 6A

decreases expression

methylselenic acid results in decreased expression of SERPINB6 mRNA

NCBI chr17:31,076,811...31,195,035
Ensembl chr17:30,871,468...31,014,427

G

serpin family E member 2

increases expression

methylselenic acid results in increased expression of SERPINE2 mRNA

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:81,124,804...81,188,826

G

serpin family F member 1

increases expression

methylselenic acid results in increased expression of SERPINF1 mRNA

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646

G

serum/glucocorticoid regulated kinase 1

affects expression

methylselenic acid affects the expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

SH3 domain binding glutamate-rich protein

increases expression

methylselenic acid results in increased expression of SH3BGR mRNA

NCBI chr11:35,503,663...35,527,853
Ensembl chr11:35,503,725...35,527,853

G

SH3-domain binding protein 5

affects expression

methylselenic acid affects the expression of SH3BP5 mRNA

NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,583,465...6,698,975

G

solute carrier family 14 member 1 (Kidd blood group)

increases expression

methylselenic acid results in increased expression of SLC14A1 mRNA

NCBI chr18:73,840,568...73,883,925
Ensembl chr18:71,565,454...71,595,146

G

solute carrier family 16 member 7

increases expression

methylselenic acid results in increased expression of SLC16A7 mRNA

NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:61,051,167...61,154,994

G

solute carrier family 19 member 1

decreases expression

methylselenic acid results in decreased expression of SLC19A1 mRNA

NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972

G

SMAD family member 7

increases expression

methylselenic acid results in increased expression of SMAD7 mRNA

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

decreases expression

methylselenic acid results in decreased expression of SMARCA4 mRNA

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:20,167,717...20,258,975

G

SWI/SNF related BAF chromatin remodeling complex subunit D3

increases expression

methylselenic acid results in increased expression of SMARCD3 mRNA

NCBI chr 4:11,441,142...11,472,781
Ensembl chr 4:10,548,751...10,580,326

G

SWI/SNF related BAF chromatin remodeling complex subunit E1

decreases expression

methylselenic acid results in decreased expression of SMARCE1 mRNA

NCBI chr10:84,655,468...84,678,259
Ensembl chr10:84,159,275...84,179,989

G

snail family transcriptional repressor 2

increases expression

methylselenic acid results in increased expression of SNAI2 mRNA

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200

G

synaptosome associated protein 25

increases expression

methylselenic acid results in increased expression of SNAP25 mRNA

NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:124,041,898...124,123,760

G

synuclein, gamma

increases expression

methylselenic acid results in increased expression of SNCG mRNA

NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,700,514...9,705,368

G

staphylococcal nuclease and tudor domain containing 1

decreases expression

methylselenic acid results in decreased expression of SND1 mRNA

NCBI chr 4:58,060,689...58,459,926
Ensembl chr 4:57,095,208...57,530,843

G

sorting nexin 1

increases expression

methylselenic acid results in increased expression of SNX1 mRNA

NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360

G

sorbin and SH3 domain containing 1

increases expression

methylselenic acid results in increased expression of SORBS1 mRNA

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169

G

Sp1 transcription factor

multiple interactions

methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

SAM pointed domain containing ets transcription factor

increases expression

methylselenic acid results in increased expression of SPDEF protein

NCBI chr20:5,773,236...5,787,685
Ensembl chr20:5,771,441...5,785,893

G

spectrin, alpha, non-erythrocytic 1

increases expression

methylselenic acid results in increased expression of SPTAN1 mRNA

NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:13,241,217...13,306,046

G

signal recognition particle 19

decreases expression

methylselenic acid results in decreased expression of SRP19 mRNA

NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017

G

single-stranded DNA binding protein 2

increases expression

methylselenic acid results in increased expression of SSBP2 mRNA

NCBI chr 2:24,385,494...24,673,768
Ensembl chr 2:22,651,258...22,933,696

G

suppression of tumorigenicity 7

decreases expression
affects expression

methylselenic acid results in decreased expression of ST7 mRNA
methylselenic acid affects the expression of ST7 mRNA

PMID:14617803 PMID:18548127

NCBI chr 4:47,007,568...47,255,639
Ensembl chr 4:46,042,236...46,289,740

G

stomatin

increases expression

methylselenic acid results in increased expression of STOM mRNA

NCBI chr 3:39,042,503...39,064,818
Ensembl chr 3:18,644,378...18,667,354

G

syntaxin 12

increases expression

methylselenic acid results in increased expression of STX12 mRNA

NCBI chr 5:150,347,554...150,376,426
Ensembl chr 5:145,063,587...145,092,377

G

syntaxin 1A

affects expression

methylselenic acid affects the expression of STX1A mRNA

NCBI chr12:27,278,517...27,306,547
Ensembl chr12:21,641,969...21,669,930

G

syntaxin 2

increases expression

methylselenic acid results in increased expression of STX2 mRNA

NCBI chr12:33,315,447...33,350,788
Ensembl chr12:27,689,819...27,714,751

G

supervillin

increases expression

methylselenic acid results in increased expression of SVIL mRNA

NCBI chr17:57,343,910...57,539,508
Ensembl chr17:52,648,502...52,793,404

G

tumor-associated calcium signal transducer 2

decreases expression

methylselenic acid results in decreased expression of TACSTD2 mRNA

NCBI chr 4:98,037,620...98,039,320
Ensembl chr 4:96,707,951...96,709,650

G

Tarbp2 subunit of RISC loading complex

decreases expression

methylselenic acid results in decreased expression of TARBP2 mRNA

NCBI chr 7:135,527,710...135,532,826
Ensembl chr 7:133,649,090...133,654,314

G

transducin (beta)-like 1 X-linked

increases expression

methylselenic acid results in increased expression of TBL1X mRNA

NCBI chr X:45,452,983...45,609,532
Ensembl chr X:41,576,047...41,731,101

G

thromboxane A synthase 1

decreases expression

methylselenic acid results in decreased expression of TBXAS1 mRNA

NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096

G

transcobalamin 2

increases expression

methylselenic acid results in increased expression of TCN2 mRNA

NCBI chr14:83,036,935...83,052,187
Ensembl chr14:78,813,343...78,828,489

G

trefoil factor 1

multiple interactions

methylselenic acid inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]; methylselenic acid inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]

PMID:16093440 PMID:16155795

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

increases expression

methylselenic acid results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

increases expression

methylselenic acid results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta receptor 2

increases expression

methylselenic acid results in increased expression of TGFBR2 mRNA

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228

G

transforming growth factor beta receptor 3

increases expression

methylselenic acid results in increased expression of TGFBR3 mRNA

PMID:12517777 PMID:18548127

NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,489,397...2,663,341

G

TLE family member 2, transcriptional corepressor

increases expression

methylselenic acid results in increased expression of TLE2 mRNA

NCBI chr 7:8,769,815...8,789,493
Ensembl chr 7:8,119,053...8,134,306

G

toll-like receptor 2

increases expression

methylselenic acid results in increased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630

G

TNF alpha induced protein 3

affects expression

methylselenic acid affects the expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 25

increases expression

methylselenic acid results in increased expression of TNFRSF25 mRNA

NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:162,622,075...162,626,341

G

DNA topoisomerase II alpha

affects expression

methylselenic acid affects the expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

G

torsin 1A interacting protein 1

increases expression

methylselenic acid results in increased expression of TOR1AIP1 mRNA

NCBI chr13:70,746,941...70,776,382
Ensembl chr13:68,196,681...68,225,862

G

tropomyosin 1

increases expression

methylselenic acid results in increased expression of TPM1 mRNA

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802

G

tribbles pseudokinase 1

decreases expression

methylselenic acid results in decreased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:91,206,579...91,214,731

G

tripartite motif-containing 14

decreases expression

methylselenic acid results in decreased expression of TRIM14 mRNA

NCBI chr 5:65,596,149...65,620,434
Ensembl chr 5:60,800,032...60,824,858

G

Ttk protein kinase

decreases expression

methylselenic acid results in decreased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651

G

thioredoxin reductase 1

increases metabolic processing

TXNRD1 protein results in increased metabolism of methylselenic acid

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

thymidylate synthetase

decreases expression
affects expression

methylselenic acid results in decreased expression of TYMS mRNA
methylselenic acid affects the expression of TYMS mRNA

PMID:12517777 PMID:14617803

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

uridine-cytidine kinase 2

decreases expression

methylselenic acid results in decreased expression of UCK2 mRNA

NCBI chr13:81,913,732...81,971,036
Ensembl chr13:79,383,846...79,438,352

G

UDP-glucose 6-dehydrogenase

affects expression

methylselenic acid affects the expression of UGDH mRNA

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354

G

utrophin

decreases expression

methylselenic acid results in decreased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313

G

vesicle-associated membrane protein 3

increases expression

methylselenic acid results in increased expression of VAMP3 mRNA

NCBI chr 5:166,780,927...166,791,522
Ensembl chr 5:161,498,109...161,508,751

G

vitamin D receptor

affects expression

methylselenic acid affects the expression of VDR mRNA

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor C

decreases expression

methylselenic acid results in decreased expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

G

vimentin

increases expression

methylselenic acid results in increased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

WASP family member 1

affects expression

methylselenic acid affects the expression of WASF1 mRNA

NCBI chr20:45,908,458...45,956,118
Ensembl chr20:44,325,795...44,372,996

G

Wnt family member 7A

decreases expression

methylselenic acid results in decreased expression of WNT7A mRNA

NCBI chr 4:125,420,276...125,466,149
Ensembl chr 4:123,863,108...123,908,981

G

WD repeat and SOCS box-containing 2

decreases expression

methylselenic acid results in decreased expression of WSB2 mRNA

NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640

G

X-box binding protein 1

increases splicing

methylselenic acid results in increased splicing of XBP1 mRNA

PMID:16205645 PMID:28161410

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreases expression

methylselenic acid results in decreased expression of YWHAE mRNA

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:60,584,652...60,671,589

G

zinc finger CCHC-type containing 24

increases expression

methylselenic acid results in increased expression of ZCCHC24 mRNA

NCBI chr16:1,281,350...1,333,278
Ensembl chr16:1,274,548...1,326,696

G

zinc finger protein 110

increases expression

methylselenic acid results in increased expression of ZNF274 mRNA

NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086

G

zinc finger protein 217

increases expression

methylselenic acid results in increased expression of ZNF217 mRNA

NCBI chr 3:179,309,178...179,349,853
Ensembl chr 3:158,892,265...158,913,040

G

zinc finger protein 24

decreases expression

methylselenic acid results in decreased expression of ZNF24 mRNA

NCBI chr18:15,573,031...15,583,432
Ensembl chr18:15,298,290...15,306,799

G

zinc finger protein 267

increases expression

methylselenic acid results in increased expression of ZNF267 mRNA

NCBI chr 2:120,945,434...120,964,039
Ensembl chr 2:119,017,285...119,031,900

G

zinc finger protein 458

decreases expression

methylselenic acid results in decreased expression of ZNF43 mRNA

NCBI chr 2:86,369,495...86,410,904
Ensembl chr 2:84,693,186...84,702,558

G

zinc finger protein 75D

increases expression

methylselenic acid results in increased expression of ZNF75D mRNA

NCBI chr X:134,035,116...134,053,765
Ensembl chr X:134,036,143...134,051,519

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19887
role	19858
application	19697
pharmaceutical	19534
drug	19534
antineoplastic agent	17832
methylseleninic acid	405
Path 2
Term	Annotations
CHEBI ontology	19887
subatomic particle	19885
composite particle	19885
hadron	19885
baryon	19885
nucleon	19885
atomic nucleus	19885
atom	19885
main group element atom	19824
p-block element atom	19824
chalcogen	19580
oxygen atom	19551
oxygen molecular entity	19551
hydroxides	19361
oxoacid	18797
chalcogen oxoacid	13803
selenium oxoacid	1822
seleninic acid	405
methylseleninic acid	405

paths to the root