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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-naphthoflavone
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Accession:CHEBI:76995 term browser browse the term
Definition:An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Synonyms:exact_synonym: 2-phenyl-4H-benzo[h]chromen-4-one
 related_synonym: 2-phenyl-4H-naphtho(1,2-b)pyran-4-one;   7,8-BF;   7,8-benzoflavone;   Formula=C19H12O2;   InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H;   InChIKey=VFMMPHCGEFXGIP-UHFFFAOYSA-N;   SMILES=O=c1cc(oc2c3ccccc3ccc12)-c1ccccc1;   alpha-naphthylflavone;   benzo[h]flavone
 xref: CAS:604-59-1
 xref_mesh: MESH:C011512
 xref: MetaCyc:CPD-10550;   PDBeChem:BHF;   PMID:143;   PMID:14564451;   PMID:17889503;   PMID:22716253;   PMID:5347522;   PMID:6474163;   PMID:6710497;   PMID:7248934;   PMID:8381508;   PMID:9831487;   Reaxys:210862;   Wikipedia:Alpha-Naphthoflavone

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alpha-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions EXP [alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of ADAMTS1 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ADAMTS1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of ADAMTS1 promoter] CTD PMID:29094188 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974 		JBrowse link
G Ahr aryl hydrocarbon receptor affects binding
decreases activity
multiple interactions		 ISO
EXP		 [alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein; [alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein; [alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein; alpha-naphthoflavone binds to AHR protein
alpha-naphthoflavone results in decreased activity of AHR protein
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [alpha-naphthoflavone results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; alpha-naphthoflavone analog inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[benzo(k)fluoranthene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of AHR protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]; alpha-naphthoflavone inhibits the reaction [AHR protein binds to and results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]; alpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Benzo(a)pyrene; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone binds to and results in increased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]
[alpha-naphthoflavone results in decreased activity of AHR protein] which results in decreased expression of CYP1A1 mRNA; AHR gene mutant form inhibits the reaction [alpha-naphthoflavone results in increased expression of IGFBP4 protein]; AHR protein promotes the reaction [alpha-naphthoflavone results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone binds to and results in increased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of AHR mRNA]		 CTD PMID:1329656 PMID:7669069 PMID:8390116 PMID:8738555 PMID:9006915 PMID:10593590 PMID:10620335 PMID:11165043 PMID:11516172 PMID:11577022 PMID:11768231 PMID:12051995 PMID:12093619 PMID:12111005 PMID:12559965 PMID:12644593 PMID:12799773 PMID:14993811 PMID:15019843 PMID:15041469 PMID:15364539 PMID:15459018 PMID:15797623 PMID:16054781 PMID:16359657 PMID:17669606 PMID:17681673 PMID:18072750 PMID:18259752 PMID:19828881 PMID:20187624 PMID:20634293 PMID:21127131 PMID:21205633 PMID:21732638 PMID:21835898 PMID:22975028 PMID:23639626 PMID:24161567 PMID:26519956 PMID:29094188 PMID:29935983 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases methylation		 EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of AKT1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of AKT1 mRNA]
alpha-naphthoflavone results in increased methylation of AKT1 promoter		 CTD PMID:29094188 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ar androgen receptor multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of AR protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]
alpha-naphthoflavone results in increased expression of AR protein		 CTD PMID:12970580 PMID:15041469 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO alpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]
ARNT protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]		 CTD PMID:11768231 PMID:21127131 PMID:30508555 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in increased expression of BAX mRNA]
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of BAX mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of BAX promoter]		 CTD PMID:20562217 PMID:29094188 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bmp15 bone morphogenetic protein 15 multiple interactions EXP [Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of BMP15 mRNA CTD PMID:29094188 NCBI chr  X:17,016,831...17,021,894
Ensembl chr  X:17,016,778...17,023,418 		JBrowse link
G Bpgm bisphosphoglycerate mutase multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA]
alpha-naphthoflavone results in increased expression of BPGM mRNA		 CTD PMID:23152189 NCBI chr 4:61,912,210...61,940,697
Ensembl chr 4:61,912,210...61,940,696 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA] CTD PMID:16489025 PMID:18259752 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Calr calreticulin multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CALR mRNA] CTD PMID:29094188 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Casp12 caspase 12 increases cleavage ISO alpha-naphthoflavone results in increased cleavage of CASP12 protein CTD PMID:30508555 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
decreases activity		 ISO
EXP		 alpha-naphthoflavone results in increased activity of CASP3 protein
alpha-naphthoflavone results in increased cleavage of CASP3 protein
alpha-naphthoflavone results in decreased activity of CASP3 protein		 CTD PMID:15710172 PMID:18334599 PMID:30508555 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO alpha-naphthoflavone results in increased activity of CASP8 protein CTD PMID:18334599 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO
EXP		 alpha-naphthoflavone results in increased activity of CASP9 protein
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of CASP9 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CASP9 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CASP9 promoter]		 CTD PMID:18334599 PMID:29094188 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] CTD PMID:20600218 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CCL1] CTD PMID:16679317 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases expression
multiple interactions		 ISO alpha-naphthoflavone results in decreased expression of CCL2 mRNA
alpha-naphthoflavone results in increased expression of CCL2 mRNA
alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL2 mRNA]		 CTD PMID:22262711 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CCNB1 mRNA] CTD PMID:25051199 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cd9 CD9 molecule multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA] CTD PMID:29094188 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein] CTD PMID:22266097 PMID:25051199 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdh13 cadherin 13 multiple interactions EXP AHR protein promotes the reaction [alpha-naphthoflavone results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH13 mRNA] CTD PMID:12559965 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein] CTD PMID:22266097 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases methylation		 EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased methylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CDK2 mRNA]
alpha-naphthoflavone results in decreased methylation of CDK2 promoter		 CTD PMID:29094188 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [eupatorin-5-methyl ether results in increased expression of CDKN1A protein]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein] CTD PMID:21887816 PMID:22266097 PMID:23994263 PMID:24361490 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] CTD PMID:15157999 PMID:22266097 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of CEBPD mRNA] CTD PMID:21652769 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA] CTD PMID:20801209 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]] CTD PMID:11165043 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Cygb cytoglobin multiple interactions ISO alpha-naphthoflavone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions
increases expression		 ISO alpha-naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]
alpha-naphthoflavone results in increased expression of CYP11B1 mRNA		 CTD PMID:22172629 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO alpha-naphthoflavone results in decreased expression of CYP17A1 mRNA CTD PMID:24875446 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [alpha-naphthoflavone results in decreased activity of CYP19A1 protein] which results in decreased susceptibility to o,p'-DDT; alpha-naphthoflavone binds to and results in decreased activity of CYP19A1 protein; alpha-naphthoflavone inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP19A1 protein]
alpha-naphthoflavone results in increased expression of CYP19A1 protein		 CTD PMID:9435150 PMID:20678559 PMID:20823264 PMID:21296134 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
affects binding
increases expression
multiple interactions
decreases activity		 ISO
EXP		 alpha-naphthoflavone results in increased activity of CYP1A1 protein
CYP1A1 protein binds to alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A1 mRNA
alpha-naphthoflavone analog results in increased expression of CYP1A1 mRNA; alpha-naphthoflavone results in increased expression of CYP1A1 mRNA; alpha-naphthoflavone results in increased expression of CYP1A1 protein
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[benzo(k)fluoranthene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Resveratrol results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [STO 609 results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone results in decreased activity of CYP1A1 protein
[alpha-naphthoflavone results in decreased activity of AHR protein] which results in decreased expression of CYP1A1 mRNA; [alpha-naphthoflavone results in decreased activity of CYP1A1 protein] inhibits the reaction [Vinyl Compounds analog results in decreased susceptibility to sodium arsenite]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [norisoboldine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone analog results in increased activity of CYP1A1 protein		 CTD PMID:1329656 PMID:6477826 PMID:7669069 PMID:8390116 PMID:8637871 PMID:9169082 PMID:10496962 PMID:11339718 PMID:11516172 PMID:11768231 PMID:12051995 PMID:12093619 PMID:12111005 PMID:12799773 PMID:12859983 PMID:14993811 PMID:15075337 PMID:15276085 PMID:15306208 PMID:15385644 PMID:15456928 PMID:15698582 PMID:15766918 PMID:15893423 PMID:16426572 PMID:16906435 PMID:17069994 PMID:17275222 PMID:17872374 PMID:18308446 PMID:18493746 PMID:18755850 PMID:19244278 PMID:19553035 PMID:19828881 PMID:19901195 PMID:20187624 PMID:20801209 PMID:20816883 PMID:20823264 PMID:21053930 PMID:21127131 PMID:21162728 PMID:21621526 PMID:21652769 PMID:21732638 PMID:21932800 PMID:22837390 PMID:22975028 PMID:23099484 PMID:24161567 PMID:24361490 PMID:26221077 PMID:27163632 PMID:27393915 PMID:27966929 PMID:29094188 PMID:29274324 PMID:30508555 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects binding
increases expression
increases metabolic processing
affects metabolic processing
decreases activity		 ISO
EXP		 [alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; alpha-naphthoflavone binds to and results in decreased activity of CYP1A2 protein; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein binds to alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A2 protein
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with alpha-naphthoflavone] results in increased expression of CYP1A2 protein; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde
CYP1A2 protein results in increased metabolism of alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A2 mRNA; alpha-naphthoflavone results in increased expression of CYP1A2 protein
CYP1A2 protein affects the metabolism of alpha-naphthoflavone		 CTD PMID:2180560 PMID:9305587 PMID:15306208 PMID:15766918 PMID:15860655 PMID:17702393 PMID:18493746 PMID:19828881 PMID:20448087 PMID:20816883 PMID:21053930 PMID:21766881 PMID:21932800 PMID:26599973 PMID:27966929 PMID:28887089 PMID:29074051 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
affects binding
increases metabolic processing
increases expression
decreases expression
decreases activity		 ISO
EXP		 alpha-naphthoflavone binds to and results in decreased activity of CYP1B1 protein; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA]; alpha-naphthoflavone inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1B1 mRNA]; alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein co-treated with NADP] results in increased metabolism of 2,4,3',5'-tetramethoxystilbene]; alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene] which results in increased expression of TP53 protein modified form]; alpha-naphthoflavone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
CYP1B1 protein binds to alpha-naphthoflavone
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased metabolism of alpha-naphthoflavone
alpha-naphthoflavone inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]
alpha-naphthoflavone results in increased expression of CYP1B1 mRNA
alpha-naphthoflavone results in decreased expression of CYP1B1 mRNA
alpha-naphthoflavone results in decreased activity of CYP1B1 protein		 CTD PMID:11577022 PMID:15075337 PMID:15280921 PMID:16120791 PMID:19182260 PMID:19563207 PMID:20823264 PMID:21053930 PMID:22262711 PMID:27163632 PMID:27966929 PMID:29146461 PMID:32553695 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]] CTD PMID:19244278 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2C11 mRNA] CTD PMID:18467041 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] CTD PMID:20187624 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO alpha-naphthoflavone results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
affects binding
increases activity
decreases activity		 ISO [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; alpha-naphthoflavone binds to and results in decreased activity of CYP3A4 protein; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
alpha-naphthoflavone binds to CYP3A4 protein
alpha-naphthoflavone results in decreased activity of CYP3A4 protein		 CTD PMID:1740010 PMID:2271712 PMID:15005856 PMID:17198380 PMID:19299527 PMID:21053930 PMID:31756459 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Dazl deleted in azoospermia-like multiple interactions ISO alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA] CTD PMID:20562217 NCBI chr 9:12,633,983...12,651,017
Ensembl chr 9:12,633,990...12,650,938 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO alpha-naphthoflavone results in increased expression of DDIT3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; ARNT protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SB 203580 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]		 CTD PMID:30508555 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA] CTD PMID:29094188 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789 		JBrowse link
G Ddx4 DEAD-box helicase 4 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA] CTD PMID:20562217 NCBI chr 2:44,447,610...44,504,263
Ensembl chr 2:44,447,573...44,504,354 		JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA] CTD PMID:29094188 NCBI chr10:94,979,759...94,988,461
Ensembl chr10:94,980,928...94,988,461 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DLL1 mRNA] CTD PMID:29094188 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases methylation
multiple interactions		 EXP alpha-naphthoflavone results in decreased methylation of DNAJB6 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of DNAJB6 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DNAJB6 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of DNAJB6 promoter]		 CTD PMID:29094188 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890 		JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 protein] CTD PMID:19578757 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:17934341 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EGLN1 mRNA] CTD PMID:18072750 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO alpha-naphthoflavone results in increased phosphorylation of EIF2S1 protein CTD PMID:30508555 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Eno1 enolase 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA] CTD PMID:23152189 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA] CTD PMID:19028555 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001 		JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] CTD PMID:24361490 NCBI chr12:25,161,130...25,168,182
Ensembl chr12:25,161,130...25,168,182 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO
EXP		 [alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Estradiol binds to ESR1 protein]]
[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR1 mRNA; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA]		 CTD PMID:10620335 PMID:15253042 PMID:22975028 PMID:29094188 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP [alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR2 mRNA CTD PMID:22975028 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Esrra estrogen related receptor, alpha affects binding ISO [alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein CTD PMID:10620335 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FAS mRNA] CTD PMID:16940415 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FASL mRNA] CTD PMID:16940415 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:20876236 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Flg filaggrin multiple interactions ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA] CTD PMID:21835898 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of FOS mRNA]] CTD PMID:10478842 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Foxn3 forkhead box N3 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of FOXN3 mRNA] CTD PMID:29094188 NCBI chr 6:123,183,720...123,577,719
Ensembl chr 6:123,187,726...123,577,695 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO
EXP		 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]
[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA		 CTD PMID:22266097 PMID:29094188 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA] CTD PMID:26640276 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FSHR protein] CTD PMID:20823264 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817 		JBrowse link
G Gdf9 growth differentiation factor 9 increases expression
multiple interactions		 EXP alpha-naphthoflavone results in increased expression of GDF9 mRNA
[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of GDF9 mRNA		 CTD PMID:29094188 NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940 		JBrowse link
G Gpi glucose-6-phosphate isomerase multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GPI mRNA]
alpha-naphthoflavone results in increased expression of GPI mRNA		 CTD PMID:23152189 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSR mRNA] CTD PMID:23152189 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO alpha-naphthoflavone results in decreased expression of GSTP1 mRNA CTD PMID:18762178 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HES1 mRNA] CTD PMID:29094188 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248 		JBrowse link
G Hk1 hexokinase 1 multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HK1 mRNA]
alpha-naphthoflavone results in increased expression of HK1 mRNA		 CTD PMID:23152189 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HSPA8 mRNA] CTD PMID:29094188 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of ICAM1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of ICAM1 mRNA] CTD PMID:26519956 PMID:29094188 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Igf2 insulin-like growth factor 2 decreases acetylation
multiple interactions		 EXP alpha-naphthoflavone results in decreased acetylation of IGF2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]		 CTD PMID:29094188 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions
increases expression		 EXP AHR gene mutant form inhibits the reaction [alpha-naphthoflavone results in increased expression of IGFBP4 protein] CTD PMID:23639626 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 protein]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]		 CTD PMID:11737050 PMID:17681673 PMID:26640276 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression		 ISO alpha-naphthoflavone analog inhibits the reaction [IL1B protein results in increased expression of SAA1 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]
alpha-naphthoflavone results in increased expression of IL1B mRNA
alpha-naphthoflavone results in decreased expression of IL1B mRNA		 CTD PMID:14993811 PMID:15019843 PMID:18617548 PMID:21127131 PMID:22262711 PMID:27393915 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1RN mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA]
alpha-naphthoflavone results in increased expression of IL1RN mRNA		 CTD PMID:22262711 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]
alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of IL6 mRNA]
alpha-naphthoflavone results in increased expression of IL6 mRNA		 CTD PMID:21162728 PMID:26519956 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgb8 integrin subunit beta 8 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA] CTD PMID:29094188 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases methylation
multiple interactions		 EXP alpha-naphthoflavone results in decreased methylation of JAG1 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]		 CTD PMID:29094188 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO
EXP		 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]
alpha-naphthoflavone results in increased expression of JUN mRNA		 CTD PMID:15019843 PMID:15897893 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Krt14 keratin 14 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of KRT14 mRNA] CTD PMID:25051199 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LDHA mRNA]
alpha-naphthoflavone results in increased expression of LDHA mRNA		 CTD PMID:23152189 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHCGR protein] CTD PMID:20823264 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]
alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein
SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19578757 PMID:20876236 PMID:21205633 PMID:26358519 PMID:30508555 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]
SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19578757 PMID:20876236 PMID:21205633 PMID:26358519 PMID:30508555 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA] CTD PMID:19578757 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP
ISO		 alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP1 mRNA]
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]]		 CTD PMID:15075337 PMID:19022365 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA] CTD PMID:19022365 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA] CTD PMID:19022365 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO		 alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]		 CTD PMID:19022365 PMID:23462309 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mt1 metallothionein 1 increases expression ISO alpha-naphthoflavone results in increased expression of MT1 mRNA CTD PMID:14998373 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein] CTD PMID:22266097 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYC protein] CTD PMID:22100782 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myog myogenin multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYOG protein] CTD PMID:24431215 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA] CTD PMID:19559082 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NDUFS1 mRNA] CTD PMID:23152189 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NDUFS3 mRNA] CTD PMID:23152189 NCBI chr 3:79,721,686...79,728,863
Ensembl chr 3:79,721,694...79,728,879 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein] CTD PMID:19028555 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] CTD PMID:26086121 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Notch2 notch receptor 2 decreases acetylation
increases methylation
multiple interactions		 EXP alpha-naphthoflavone results in decreased acetylation of NOTCH2 promoter
alpha-naphthoflavone results in increased methylation of NOTCH2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of NOTCH2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of NOTCH2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of NOTCH2 promoter]		 CTD PMID:29094188 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 EXP alpha-naphthoflavone results in increased activity of NQO1 protein
alpha-naphthoflavone results in increased expression of NQO1 mRNA		 CTD PMID:16906435 PMID:17069994 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP alpha-naphthoflavone results in increased activity of NR1I3 protein CTD PMID:27732639 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 affects binding ISO [alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein CTD PMID:10620335 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpha-naphthoflavone results in increased cleavage of PARP1 protein CTD PMID:30508555 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA]
alpha-naphthoflavone results in increased expression of PFKM mRNA		 CTD PMID:23152189 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGK1 mRNA]
alpha-naphthoflavone results in increased expression of PGK1 mRNA		 CTD PMID:23152189 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367 		JBrowse link
G Pgm1 phosphoglucomutase 1 increases expression
multiple interactions		 ISO alpha-naphthoflavone results in increased expression of PGM1 mRNA
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGM1 mRNA]		 CTD PMID:23152189 NCBI chr 5:118,743,632...118,803,055
Ensembl chr 5:118,743,632...118,803,055 		JBrowse link
G Pgr progesterone receptor increases expression ISO alpha-naphthoflavone results in increased expression of PGR protein CTD PMID:22266097 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PKM mRNA] CTD PMID:23152189 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of PPARA protein] CTD PMID:21849270 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA] CTD PMID:20562217 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of PRKCB protein] CTD PMID:16797713 PMID:17222441 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Prl prolactin multiple interactions EXP alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of PRL mRNA] CTD PMID:22975028 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
increases expression		 ISO alpha-naphthoflavone results in decreased expression of PTGS2 mRNA
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
alpha-naphthoflavone results in increased expression of PTGS2 mRNA		 CTD PMID:21162728 PMID:21652769 PMID:22262711 PMID:26358519 PMID:27393915 PMID:32526215 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased phosphorylation of PTK2 protein] CTD PMID:16359657 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119 		JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RACK1 protein] CTD PMID:16797713 PMID:17222441 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] CTD PMID:15157999 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO alpha-naphthoflavone inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of RELA protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of RELA protein] CTD PMID:24431215 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions
decreases expression
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINB2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]]
alpha-naphthoflavone results in decreased expression of SERPINB2 mRNA
alpha-naphthoflavone results in increased expression of SERPINB2 mRNA		 CTD PMID:15075337 PMID:22262711 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression		 ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A1 mRNA]
alpha-naphthoflavone results in increased expression of SLC2A1 mRNA		 CTD PMID:23152189 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein] CTD PMID:26519956 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] CTD PMID:27519288 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA] CTD PMID:29094188 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation		 ISO SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
alpha-naphthoflavone results in increased phosphorylation of SRC protein		 CTD PMID:30508555 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein] CTD PMID:21205633 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
G Tcf7 transcription factor 7 increases expression ISO alpha-naphthoflavone results in increased expression of TCF7 mRNA CTD PMID:18762178 NCBI chr10:37,616,033...37,646,027
Ensembl chr10:37,617,279...37,645,802 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of TGFB1 mRNA]
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]		 CTD PMID:22975028 PMID:27519288 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase decreases expression
multiple interactions		 ISO alpha-naphthoflavone results in decreased expression of TIPARP mRNA
alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of TIPARP mRNA]		 CTD PMID:18762178 PMID:21652769 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of TNF mRNA]
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein]		 CTD PMID:17934341 PMID:20801209 PMID:23099484 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]] CTD PMID:26221077 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP
ISO		 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]
alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene] which results in increased expression of TP53 protein modified form]
alpha-naphthoflavone results in increased expression of TP53 protein
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene affects the localization of TRP53 protein]		 CTD PMID:9006915 PMID:15459018 PMID:29274324 PMID:32553695 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression
multiple interactions		 ISO alpha-naphthoflavone results in increased expression of TPI1 mRNA
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNA]		 CTD PMID:23152189 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
Ensembl chr 9:157,328,379...157,331,905 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]] CTD PMID:19244278 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP		 alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA protein]; alpha-naphthoflavone promotes the reaction [Chlorpyrifos results in increased expression of VEGFA protein]
alpha-naphthoflavone inhibits the reaction [norisoboldine results in decreased expression of VEGFA mRNA]
alpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]		 CTD PMID:19182260 PMID:26221077 PMID:26358519 PMID:32526215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Wapl WAPL cohesin release factor multiple interactions ISO alpha-naphthoflavone promotes the reaction [3-methylcholanthrylene results in increased expression of WAPL mRNA] CTD PMID:15797623 NCBI chr16:11,029,325...11,108,867
Ensembl chr16:11,032,531...11,106,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        pharmacological role 18830
          agonist 18253
            aryl hydrocarbon receptor agonist 1929
              alpha-naphthoflavone 139
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      ketone 16825
                                        cyclic ketone 15234
                                          naphtho-gamma-pyrone 1199
                                            alpha-naphthoflavone 139
paths to the root