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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC (membrane dipeptidase) inhibitor
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Accession:CHEBI:76926 term browser browse the term
Definition:An EC 3.4.13.* (dipeptidase) inhibitor that interferes with the action of membrane dipeptidase (EC
Synonyms:related_synonym: DPH I inhibitors;   EC inhibitor;   EC inhibitors;   MDP inhibitors;   aminodipeptidase inhibitors;   dehydropeptidase I (DPH I) inhibitors;   dehydropeptidase I inhibitors;   dipeptidase inhibitors;   dipeptide hydrolase inhibitors;   dipeptidyl hydrolase inhibitors;   glycosyl-phosphatidylinositol-anchored renal dipeptidase inhibitors;   membrane dipeptidase (EC inhibitors;   membrane dipeptidase inhibitor;   membrane dipeptidase inhibitors;   microsomal dipeptidase inhibitors;   nonspecific dipeptidase inhibitors;   renal dipeptidase inhibitors

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cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Dpep1 dipeptidase 1 decreases activity ISO Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          enzyme inhibitor 18571
            EC 3.* (hydrolase) inhibitor 18134
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4279
                EC 3.4.13.* (dipeptidase) inhibitor 2
                  EC (membrane dipeptidase) inhibitor 2
                    cilastatin 2
                    cilastatin sodium 0
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