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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC (membrane dipeptidase) inhibitor
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Accession:CHEBI:76926 term browser browse the term
Definition:An EC 3.4.13.* (dipeptidase) inhibitor that interferes with the action of membrane dipeptidase (EC
Synonyms:related_synonym: DPH I inhibitors;   EC inhibitor;   EC inhibitors;   MDP inhibitors;   aminodipeptidase inhibitors;   dehydropeptidase I (DPH I) inhibitors;   dehydropeptidase I inhibitors;   dipeptidase inhibitors;   dipeptide hydrolase inhibitors;   dipeptidyl hydrolase inhibitors;   glycosyl-phosphatidylinositol-anchored renal dipeptidase inhibitors;   membrane dipeptidase (EC inhibitors;   membrane dipeptidase inhibitor;   membrane dipeptidase inhibitors;   microsomal dipeptidase inhibitors;   nonspecific dipeptidase inhibitors;   renal dipeptidase inhibitors

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cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G DPEP1 dipeptidase 1 decreases activity EXP Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr16:89,613,308...89,641,540
Ensembl chr16:89,613,308...89,638,456
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 25336
    role 25263
      biological role 25237
        biochemical role 24617
          enzyme inhibitor 21567
            EC 3.* (hydrolase) inhibitor 20783
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4392
                EC 3.4.13.* (dipeptidase) inhibitor 2
                  EC (membrane dipeptidase) inhibitor 2
                    cilastatin 2
                    cilastatin sodium 0
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