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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.13.19 (membrane dipeptidase) inhibitor
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Accession:CHEBI:76926 term browser browse the term
Definition:An EC 3.4.13.* (dipeptidase) inhibitor that interferes with the action of membrane dipeptidase (EC 3.4.13.19).
Synonyms:related_synonym: DPH I inhibitors;   EC 3.4.13.19 inhibitor;   EC 3.4.13.19 inhibitors;   MDP inhibitors;   aminodipeptidase inhibitors;   dehydropeptidase I (DPH I) inhibitors;   dehydropeptidase I inhibitors;   dipeptidase inhibitors;   dipeptide hydrolase inhibitors;   dipeptidyl hydrolase inhibitors;   glycosyl-phosphatidylinositol-anchored renal dipeptidase inhibitors;   membrane dipeptidase (EC 3.4.13.19) inhibitors;   membrane dipeptidase inhibitor;   membrane dipeptidase inhibitors;   microsomal dipeptidase inhibitors;   nonspecific dipeptidase inhibitors;   renal dipeptidase inhibitors


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cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Dpep1 dipeptidase 1 decreases activity ISO Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        biochemical role 19222
          enzyme inhibitor 18144
            EC 3.* (hydrolase) inhibitor 17638
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3214
                EC 3.4.13.* (dipeptidase) inhibitor 2
                  EC 3.4.13.19 (membrane dipeptidase) inhibitor 2
                    cilastatin 2
                    cilastatin sodium 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.