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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hyperglycemic agent
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Accession:CHEBI:76916 term browser browse the term
Definition:A drug which increases the blood glucose level.
Synonyms:related_synonym: diabetes inducer;   hyperglycemic agents



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alloxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases activity
EXP Chromium inhibits the reaction [Alloxan results in increased activity of ACOX1 protein]; chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Actb actin, beta decreases expression ISO Alloxan results in decreased expression of ACTB mRNA CTD PMID:12137914 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP [Alloxan co-treated with Niacinamide] affects the expression of ADIPOQ protein CTD PMID:26429928 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
Alloxan results in decreased phosphorylation of AKT1 protein
Phycocyanin inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
CTD PMID:26827782 PMID:33359794 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions
increases expression
EXP Alloxan results in decreased expression of APAF1 protein
Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]
CTD PMID:21982801 PMID:23092809 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of ATP2A1 protein] CTD PMID:28483572 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Alloxan results in decreased expression of ATP2A2 protein CTD PMID:28483572 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
EXP Alloxan results in increased expression of BAD protein
Taurine inhibits the reaction [Alloxan results in increased expression of BAD protein]
CTD PMID:22138235 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Taurine inhibits the reaction [Alloxan results in increased expression of BAX protein] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Alloxan results in decreased expression of BCL2 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2 protein]
CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of BCL2L1 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2L1 protein]
CTD PMID:22138235 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP3 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP3 protein modified form] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
EXP Alloxan results in increased activity of CASP9 protein
Alloxan results in increased expression of CASP9 protein; Alloxan results in increased expression of CASP9 protein modified form
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP9 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein modified form]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein]
CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity
EXP
ISO
3,4-dihydroxyphenylethanol inhibits the reaction [Alloxan results in decreased expression of CAT protein]; Chromium inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Alloxan results in decreased expression of CAT protein]
Plant Oils inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Alloxan results in decreased activity of CAT protein]
CTD PMID:10871429 PMID:19393637 PMID:19693677 PMID:21982801 PMID:24946265 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [Cathelicidins results in increased expression of CCL2 protein]] CTD PMID:18949387 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein] CTD PMID:28483572 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
EXP Taurine inhibits the reaction [Alloxan affects the localization of CYCS protein] CTD PMID:22138235 PMID:23092809 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Alloxan results in increased expression of DDIT3 mRNA; Alloxan results in increased expression of DDIT3 protein CTD PMID:30076216 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions
ISO Alloxan results in decreased expression of FOXP3 protein
platycodin D inhibits the reaction [Alloxan results in decreased expression of FOXP3 protein]
CTD PMID:25887267 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases activity
multiple interactions
EXP Alloxan results in increased activity of G6PC1 protein
Sodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC1 protein]
CTD PMID:25779343 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gck glucokinase multiple interactions
decreases expression
ISO
EXP
Glucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCK protein]
Alloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK protein]
CTD PMID:12137914 PMID:26827782 PMID:33359794 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gckr glucokinase regulator decreases expression
multiple interactions
ISO Alloxan results in decreased expression of GCKR protein
Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCKR protein]
CTD PMID:26827782 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions
EXP Alloxan results in decreased expression of GCLC mRNA; Alloxan results in decreased expression of GCLC protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]
CTD PMID:33359794 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Alloxan results in increased susceptibility to titanium dioxide] which results in increased activity of GPT protein CTD PMID:23873220 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of GSR protein] CTD PMID:21982801 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of HMOX1 mRNA; Alloxan results in decreased expression of HMOX1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]
CTD PMID:33359794 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Alloxan results in increased expression of HSPA5 mRNA CTD PMID:30076216 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [Cathelicidins results in increased expression of ICAM1 protein]] CTD PMID:18949387 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Alloxan results in decreased expression of and results in decreased secretion of IL10 protein; platycodin D inhibits the reaction [Alloxan results in decreased expression of and results in decreased secretion of IL10 protein] CTD PMID:25887267 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B decreases expression ISO Alloxan results in decreased expression of IL12B protein CTD PMID:16249388 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL17A protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:25887267 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL1B protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:25887267 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Taurine inhibits the reaction [Alloxan results in increased expression of IL6 protein]
Alloxan results in increased expression of and results in increased secretion of IL6 protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]
CTD PMID:22138235 PMID:25887267 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Plant Oils inhibits the reaction [Alloxan results in decreased expression of INS1 protein]
[Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [Sertraline binds to 2-Hydroxypropyl-beta-cyclodextrin] inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; Plant Preparations inhibits the reaction [Alloxan results in decreased secretion of INS1 protein]; Sertraline inhibits the reaction [Alloxan results in decreased expression of INS1 protein]
CTD PMID:19393637 PMID:21050842 PMID:21982801 PMID:26593071 PMID:27317948 More... NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Insr insulin receptor decreases phosphorylation
multiple interactions
EXP Alloxan results in decreased phosphorylation of INSR protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein]
CTD PMID:22138235 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
affects phosphorylation
EXP
ISO
Alloxan results in decreased phosphorylation of IRS1 protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]
Alloxan affects the phosphorylation of IRS1 protein
Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]
CTD PMID:22138235 PMID:26827782 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Alloxan results in increased phosphorylation of MAPK1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK1 protein]
CTD PMID:33359794 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK3 protein] CTD PMID:33359794 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of MFN2 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein]
CTD PMID:28483572 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
EXP Alloxan results in increased activity of MPO protein
Taurine inhibits the reaction [Alloxan results in increased activity of MPO protein]
CTD PMID:22138235 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of NDUFA9 protein] CTD PMID:28483572 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
affects localization
multiple interactions
EXP Alloxan results in decreased expression of NFE2L2 mRNA
Alloxan affects the localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]]
CTD PMID:33359794 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression ISO Alloxan results in decreased expression of NOS1 mRNA CTD PMID:30076216 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Alloxan results in increased expression of NOS2 mRNA CTD PMID:30076216 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of NQO1 mRNA; Alloxan results in decreased expression of NQO1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]]
CTD PMID:33359794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Alloxan affects the reaction [imisopasem manganese results in increased expression of NRF1 protein] CTD PMID:28483572 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions
EXP Alloxan results in increased degradation of PARP1 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased degradation of PARP1 protein]
CTD PMID:21982801 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
decreases expression
EXP ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 protein]
Alloxan results in decreased expression of PDX1 mRNA; Alloxan results in decreased expression of PDX1 protein
CTD PMID:33359794 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein] CTD PMID:28483572 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO
EXP
Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Alloxan results in increased expression of RELA protein
Taurine inhibits the reaction [Alloxan results in increased expression of RELA protein]
CTD PMID:19020780 PMID:22138235 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO Alloxan results in increased expression of RORC protein
platycodin D inhibits the reaction [Alloxan results in increased expression of RORC protein]
CTD PMID:25887267 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein] CTD PMID:28483572 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression
multiple interactions
ISO
EXP
Alloxan results in decreased expression of SLC2A2 mRNA
Glucose inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]
Alloxan results in decreased expression of SLC2A2 mRNA; Alloxan results in decreased expression of SLC2A2 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 protein]
CTD PMID:12137914 PMID:33359794 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
multiple interactions
decreases expression
EXP
ISO
Alloxan affects the localization of SLC2A4 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]; Taurine inhibits the reaction [Alloxan affects the localization of SLC2A4 protein]
Quercetin inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]
CTD PMID:22138235 PMID:24946265 PMID:28483572 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sod1 superoxide dismutase 1 affects response to substance
multiple interactions
decreases activity
ISO
EXP
SOD1 protein affects the susceptibility to Alloxan
Sulfur Dioxide inhibits the reaction [Alloxan results in decreased activity of SOD1 protein]
CTD PMID:10871429 PMID:18502742 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Taurine inhibits the reaction [Alloxan results in increased expression of TNF protein]
Alloxan results in increased expression of and results in increased secretion of TNF protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]
CTD PMID:19020780 PMID:22138235 PMID:25887267 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO Alloxan results in increased expression of TRPM7 mRNA; Alloxan results in increased expression of TRPM7 protein CTD PMID:30076216 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 increases expression
multiple interactions
EXP Alloxan results in increased expression of UQCRC2 protein
imisopasem manganese promotes the reaction [Alloxan results in increased expression of UQCRC2 protein]
CTD PMID:28483572 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions
EXP Alloxan results in increased activity of XDH protein
Taurine inhibits the reaction [Alloxan results in increased activity of XDH protein]
CTD PMID:22138235 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

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  CHEBI ontology 19838
    role 19810
      application 19679
        pharmaceutical 19495
          drug 19520
            hyperglycemic agent 59
              alloxan 59
paths to the root