EC 4.1.1.* (carboxy-lyase) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	*EC 4.1.1. (carboxy-lyase) inhibitor**	go back to main search page
Accession:	CHEBI:76906	browse the term
Definition:	An EC 4.1.* (C-C lyase) inhibitor that interferes with the action of any carboxy-lyase (EC 4.1.1.*).
Synonyms:	related_synonym:	EC 4.1.1.* (carboxy-lyase) inhibitors; EC 4.1.1.* inhibitor; EC 4.1.1.* inhibitors; carboxy-lyases (EC 4.1.1.) inhibitor; carboxy-lyases (EC 4.1.1.) inhibitors

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Rat (162) Mouse (164) Human (173) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (173)

5,6,7-trimethoxyflavone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

interleukin 1 beta

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

NFKB inhibitor alpha

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 2

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

prostaglandin-endoperoxide synthase 2

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

signal transducer and activator of transcription 1

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]

NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960

G

signal transducer and activator of transcription 3

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

tumor necrosis factor

multiple interactions

5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

baicalein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases activity
multiple interactions
increases expression

baicalein results in increased activity of ABCB1 protein
baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
baicalein results in increased expression of ABCB1 protein

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

decreases activity

baicalein results in decreased activity of ABCC1 protein

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
baicalein results in decreased expression of ACTA2 protein

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

alpha fetoprotein

affects binding

baicalein binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174

G

aryl hydrocarbon receptor

multiple interactions
affects response to substance
increases activity
increases expression

AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; baicalein binds to and results in increased activity of AHR protein
AHR protein affects the susceptibility to baicalein
baicalein results in increased activity of AHR protein
baicalein results in increased expression of AHR protein

PMID:14644660 PMID:17869316 PMID:22820424

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

apoptosis inducing factor mitochondria associated 1

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]]; baicalein inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

AKT serine/threonine kinase 1

decreases phosphorylation
affects binding
increases phosphorylation
multiple interactions

baicalein results in decreased phosphorylation of AKT1 protein
baicalein binds to AKT1 protein
baicalein results in increased phosphorylation of AKT1 protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of AKT1 mRNA]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]

PMID:18025287 PMID:22820424 PMID:36988316 PMID:38230788

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

arachidonate 12-lipoxygenase, 12S type

multiple interactions
decreases activity

baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
baicalein results in decreased activity of ALOX12 protein

PMID:17027136 PMID:23238474

NCBI chr17:6,996,049...7,010,754
Ensembl chr17:6,996,049...7,010,754

G

arachidonate 15-lipoxygenase

decreases activity

baicalein results in decreased activity of ALOX15 protein

NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294

G

amyloid beta precursor protein

multiple interactions

baicalein inhibits the reaction [APP protein binds to APP protein]

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

achaete-scute family bHLH transcription factor 3

affects expression

baicalein affects the expression of ASCL3 protein

NCBI chr11:8,937,578...8,943,016
Ensembl chr11:8,937,578...8,943,016

G

achaete-scute family bHLH transcription factor 4

affects expression

baicalein affects the expression of ASCL4 protein

NCBI chr12:107,774,704...107,776,644
Ensembl chr12:107,774,704...107,776,644

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of BAX protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form]; baicalein inhibits the reaction [Bleomycin results in increased expression of BAX protein]
baicalein results in increased expression of BAX protein

PMID:20850421 PMID:21457722 PMID:37783230

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form]; baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]
baicalein results in decreased expression of BCL2 protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein]

PMID:20850421 PMID:33838155 PMID:37783230

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

baculoviral IAP repeat containing 5

decreases expression
multiple interactions

baicalein results in decreased expression of BIRC5 protein
SB 203580 inhibits the reaction [baicalein results in decreased expression of BIRC5 protein]; wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 3

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased cleavage of CASP3 protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP3 protein modified form]; baicalein inhibits the reaction [Bleomycin results in increased cleavage of CASP3 protein]

PMID:20850421 PMID:37783230

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

cyclin A2

decreases expression

baicalein results in decreased expression of CCNA2 protein

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

decreases expression

baicalein results in decreased expression of CCNB1 protein

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

multiple interactions
decreases expression
increases expression

Lithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA]

PMID:19160421 PMID:21457722 PMID:22820424 PMID:24560969 PMID:36988316

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin E1

decreases expression

baicalein results in decreased expression of CCNE1 protein

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

cyclin dependent kinase 1

decreases phosphorylation
multiple interactions

baicalein results in decreased phosphorylation of CDK1 protein
SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]; Wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 4

increases expression

baicalein results in increased expression of CDK4 protein

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase inhibitor 1A

multiple interactions

baicalein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

CCAAT enhancer binding protein alpha

decreases expression

baicalein results in decreased expression of CEBPA protein

NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534

G

CCAAT enhancer binding protein beta

decreases expression

baicalein results in decreased expression of CEBPB mRNA

NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668

G

CCAAT enhancer binding protein gamma

decreases expression

baicalein results in decreased expression of CEBPG mRNA

NCBI chr19:33,373,709...33,382,686
Ensembl chr19:33,373,685...33,382,686

G

CASP8 and FADD like apoptosis regulator

multiple interactions

baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

CF transmembrane conductance regulator

increases activity

baicalein results in increased activity of CFTR protein

NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971

G

collagen type I alpha 1 chain

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]]; baicalein inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]

PMID:30201452 PMID:37783230

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type I alpha 2 chain

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

colony stimulating factor 2

decreases expression

baicalein results in decreased expression of CSF2 mRNA

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

C-X-C motif chemokine ligand 8

multiple interactions

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of IL8 protein]

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

cytochrome c, somatic

multiple interactions

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of CYCS protein]

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

increases expression
decreases expression
multiple interactions
increases chemical synthesis
decreases activity

baicalein results in increased expression of CYP1A1 protein
baicalein results in decreased expression of CYP1A1 mRNA
[CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased chemical synthesis of baicalein
baicalein results in decreased activity of CYP1A1 protein

PMID:12224597 PMID:14644660 PMID:18451504 PMID:19666078 PMID:21053930 More...

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity
increases chemical synthesis
multiple interactions

baicalein results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased chemical synthesis of baicalein
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein

PMID:19666078 PMID:21053930 PMID:29753067

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity
increases chemical synthesis
multiple interactions

baicalein results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased chemical synthesis of baicalein
[CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein binds to and results in decreased activity of CYP1B1 protein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]

PMID:12224597 PMID:19666078 PMID:21053930 PMID:21482471

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily B member 6

increases expression

baicalein results in increased expression of CYP2B6 mRNA

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

baicalein results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

multiple interactions
decreases activity

baicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
baicalein results in decreased activity of CYP2C9 protein

PMID:21053930 PMID:29753067

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily E member 1

decreases activity

baicalein results in decreased activity of CYP2E1 protein

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

cytochrome P450 family 3 subfamily A member 4

decreases activity

baicalein results in decreased activity of CYP3A4 protein

PMID:21053930 PMID:29753067

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

diacylglycerol O-acyltransferase 1

decreases expression

baicalein results in decreased expression of DGAT1 protein

NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910

G

delta like non-canonical Notch ligand 1

increases expression

baicalein results in increased expression of DLK1 mRNA

NCBI chr14:100,726,892...100,738,224
Ensembl chr14:100,725,705...100,738,224

G

epidermal growth factor

multiple interactions

baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions
affects binding
decreases phosphorylation

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of EGFR mRNA]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of EGFR protein]
baicalein binds to EGFR protein

PMID:25625231 PMID:33838155 PMID:38230788

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 2

decreases expression

baicalein results in decreased expression of EGR2 mRNA

NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167

G

ETS transcription factor ELK1

multiple interactions

baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr X:47,635,520...47,650,604
Ensembl chr X:47,635,521...47,650,604

G

erythropoietin

increases expression

baicalein results in increased expression of EPO mRNA

NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases expression

baicalein results in decreased expression of and results in decreased phosphorylation of ERBB2 protein
baicalein results in decreased expression of ERBB2 mRNA

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

estrogen receptor 1

multiple interactions
affects binding

baicalein inhibits the reaction [Cholesterol, LDL analog results in decreased expression of ESR1 mRNA]
baicalein binds to ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

fatty acid binding protein 4

decreases expression

baicalein results in decreased expression of FABP4 protein

NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236

G

fatty acid synthase

decreases expression

baicalein results in decreased expression of FASN protein

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

fibronectin 1

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

galactosidase beta 1

multiple interactions

baicalein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]

NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202

G

GLI family zinc finger 1

decreases expression

baicalein results in decreased expression of GLI1 mRNA; baicalein results in decreased expression of GLI1 protein

NCBI chr12:57,459,785...57,472,268
Ensembl chr12:57,459,785...57,472,268

G

glycerol-3-phosphate acyltransferase 3

decreases expression

baicalein results in decreased expression of GPAT3 protein

NCBI chr 4:83,535,587...83,605,875
Ensembl chr 4:83,535,914...83,605,875

G

glutathione peroxidase 4

affects expression
multiple interactions

baicalein affects the expression of GPX4 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]

PMID:36055377 PMID:37354967

NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791

G

glycogen synthase kinase 3 beta

decreases phosphorylation
multiple interactions

baicalein results in decreased phosphorylation of GSK3B protein
baicalein inhibits the reaction [Mitomycin results in increased phosphorylation of GSK3B protein]

PMID:22820424 PMID:34624459 PMID:36988316

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

hes family bHLH transcription factor 1

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]

NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732

G

hes related family bHLH transcription factor with YRPW motif 1

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]

NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857

G

hes related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]

NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

baicalein results in increased expression of HIF1A mRNA; baicalein results in increased expression of HIF1A protein
baicalein results in decreased degradation of and results in increased expression of HIF1A protein modified form

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

heme oxygenase 1

increases expression
multiple interactions

baicalein results in increased expression of HMOX1 mRNA; baicalein results in increased expression of HMOX1 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]
Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]

PMID:14563492 PMID:37354967

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases activity

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein]

NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553

G

insulin like growth factor 1

multiple interactions

baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

interleukin 1 beta

multiple interactions

baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of IL1B protein]

PMID:22369883 PMID:38230788

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

insulin

multiple interactions
increases secretion

baicalein promotes the reaction [Glucose results in increased secretion of INS protein]
baicalein results in increased secretion of INS protein

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects binding

baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of JUN mRNA]
baicalein binds to JUN protein

PMID:17458902 PMID:38230788

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

KLF transcription factor 2

increases expression

baicalein results in increased expression of KLF2 mRNA

NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685

G

KLF transcription factor 5

decreases expression

baicalein results in decreased expression of KLF5 mRNA

NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541

G

lipin 1

decreases expression

baicalein results in decreased expression of LPIN1 protein

NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409

G

mitogen-activated protein kinase 1

multiple interactions
affects binding
decreases phosphorylation

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of MAPK1 mRNA]; baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein]
baicalein binds to MAPK1 protein
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK1 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]

PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155 PMID:38230788

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation

baicalein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK3 protein]
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK3 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein]

PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

baicalein results in decreased phosphorylation of and results in decreased activity of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

microRNA 1224

increases expression

baicalein results in increased expression of MIR1224 mRNA

NCBI chr 3:184,241,405...184,241,489
Ensembl chr 3:184,241,405...184,241,489

G

microRNA 21

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337

G

microRNA 3195

increases expression

baicalein results in increased expression of MIR3195 mRNA

NCBI chr20:62,064,802...62,064,885
Ensembl chr20:62,064,802...62,064,885

G

microRNA 3663

multiple interactions
increases expression
increases response to substance

MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of SH3GL1 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of EGFR protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK3 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]
baicalein results in increased expression of MIR3663 mRNA
MIR3663 mRNA results in increased susceptibility to baicalein

NCBI chr10:117,167,678...117,167,774
Ensembl chr10:117,167,678...117,167,774

G

microRNA 424

increases expression

baicalein results in increased expression of MIR424 mRNA

NCBI chr X:134,546,614...134,546,711
Ensembl chr X:134,546,614...134,546,711

G

microRNA 4443

increases expression

baicalein results in increased expression of MIR4443 mRNA

NCBI chr 3:48,196,564...48,196,616
Ensembl chr 3:48,196,564...48,196,616

G

microRNA 4497

increases expression

baicalein results in increased expression of MIR4497 mRNA

NCBI chr12:109,833,348...109,833,436
Ensembl chr12:109,833,348...109,833,436

G

microRNA 4674

increases expression

baicalein results in increased expression of MIR4674 mRNA

NCBI chr 9:136,546,173...136,546,259
Ensembl chr 9:136,546,173...136,546,259

G

matrix metallopeptidase 2

decreases activity
multiple interactions

baicalein results in decreased activity of MMP2 protein
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]

PMID:21803068 PMID:22369883 PMID:36988316

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions
decreases activity

baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
baicalein results in decreased activity of MMP9 protein

PMID:19804834 PMID:21803068 PMID:22369883

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

myeloperoxidase

multiple interactions

baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

mechanistic target of rapamycin kinase

multiple interactions

baicalein results in decreased phosphorylation of and results in decreased activity of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

N-acetyltransferase 1

decreases expression

baicalein results in decreased expression of NAT1 mRNA; baicalein results in decreased expression of NAT1 protein

NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689

G

nuclear factor kappa B subunit 1

decreases localization

baicalein results in decreased localization of NFKB1 protein

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions
decreases phosphorylation

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of NFKBIA protein]
baicalein results in decreased phosphorylation of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NFKB inhibitor beta

decreases phosphorylation

baicalein results in decreased phosphorylation of NFKBIB protein

NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893

G

NF-kappaB interacting lncRNA

multiple interactions
increases response to substance

NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]
NKILA mRNA results in increased susceptibility to baicalein

NCBI chr20:57,710,183...57,712,780
Ensembl chr20:57,710,156...57,712,780

G

nitric oxide synthase 2

multiple interactions
decreases expression

baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; tin protoporphyrin IX inhibits the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
baicalein results in decreased expression of NOS2 protein

PMID:14563492 PMID:20850421 PMID:22369883

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch receptor 1

increases activity
increases expression

baicalein results in increased activity of NOTCH1 protein
baicalein results in increased expression of NOTCH1 mRNA

NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048

G

nuclear receptor subfamily 1 group I member 3

affects localization

baicalein affects the localization of NR1I3 protein

NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

multiple interactions
affects binding

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of PIK3CA mRNA]
baicalein binds to PIK3CA protein

NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093

G

pyruvate kinase M1/2

increases activity

baicalein results in increased activity of PKM protein

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

phospholipase A2 group IIA

multiple interactions

baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416

G

plasminogen activator, urokinase

decreases activity

baicalein results in decreased activity of PLAU protein

NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA]

NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305

G

peroxisome proliferator activated receptor gamma

decreases expression

baicalein results in decreased expression of PPARG protein

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein kinase C alpha

decreases phosphorylation

baicalein results in decreased phosphorylation of PRKCA protein

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

prostaglandin-endoperoxide synthase 2

multiple interactions

baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]

PMID:19804834 PMID:22369883 PMID:31811862 PMID:37354967

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

glycogen phosphorylase B

decreases activity

baicalein results in decreased activity of PYGB protein

NCBI chr20:25,248,085...25,298,012
Ensembl chr20:25,248,085...25,298,012

G

glycogen phosphorylase L

decreases activity

baicalein results in decreased activity of PYGL protein

NCBI chr14:50,905,217...50,944,483
Ensembl chr14:50,857,891...50,944,483

G

RB transcriptional corepressor 1

multiple interactions
decreases phosphorylation

AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein]

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases phosphorylation
affects localization
decreases localization

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of RELA protein]; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
baicalein results in decreased phosphorylation of RELA protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]; NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]
baicalein results in decreased localization of RELA protein

PMID:20850421 PMID:21803068 PMID:22369883 PMID:29481769 PMID:33838155

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ribosomal protein S6 kinase B1

multiple interactions

baicalein results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

SH3 domain containing GRB2 like 1, endophilin A2

decreases expression
multiple interactions

baicalein results in decreased expression of SH3GL1 mRNA; baicalein results in decreased expression of SH3GL1 protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of SH3GL1 protein]

NCBI chr19:4,360,370...4,400,547
Ensembl chr19:4,360,370...4,400,547

G

sirtuin 1

multiple interactions

baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

solute carrier family 22 member 6

decreases activity

baicalein results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 7 member 11

multiple interactions

baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]

NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349

G

synuclein alpha

multiple interactions

baicalein inhibits the reaction [SNCA protein binds to SNCA protein]
baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein]

NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315

G

sprouty RTK signaling antagonist 1

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

NCBI chr 4:123,396,795...123,403,760
Ensembl chr 4:123,396,795...123,403,760

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
affects binding

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of SRC mRNA]
baicalein binds to SRC protein

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

sterol regulatory element binding transcription factor 1

decreases expression

baicalein results in decreased expression of SREBF1 protein

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

signal transducer and activator of transcription 3

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

transforming growth factor beta 1

multiple interactions

baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]]
baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

PMID:19474275 PMID:30201452 PMID:37783230

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tyrosine hydroxylase

multiple interactions

baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein]

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

tumor necrosis factor

decreases expression
multiple interactions

baicalein results in decreased expression of TNF protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of TNF protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]

PMID:20850421 PMID:22369883 PMID:38230788

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

increases expression
affects binding
multiple interactions

baicalein results in increased expression of TP53 protein
baicalein binds to TP53 protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of TP53 mRNA]; baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]

PMID:21457722 PMID:37354967 PMID:38230788

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

UDP glucuronosyltransferase family 1 member A10

decreases activity

baicalein results in decreased activity of UGT1A10 protein

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

decreases activity

baicalein results in decreased activity of UGT1A8 protein

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of baicalein

NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652

G

vascular endothelial growth factor A

decreases expression

baicalein results in decreased expression of VEGFA protein

PMID:16638750 PMID:36988316

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

xanthine dehydrogenase

multiple interactions

baicalein inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

G

X-linked inhibitor of apoptosis

multiple interactions

baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

baicalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase (Yt blood group)

multiple interactions
increases expression

baicalin results in increased expression of and results in increased activity of ACHE protein
baicalin results in increased expression of ACHE mRNA

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

aryl hydrocarbon receptor

increases activity

baicalin results in increased activity of AHR protein

PMID:17869316 PMID:26204831

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

allograft inflammatory factor 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein]

NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021

G

arachidonate 5-lipoxygenase

multiple interactions

baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]

NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119

G

angiopoietin 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of ANGPT1 mRNA]

NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055

G

activating transcription factor 2

multiple interactions

baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]

NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

baicalin results in increased expression of BAX protein
baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein]
baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]

PMID:21457722 PMID:25423838 PMID:31021006 PMID:34333357 PMID:36446982

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein]
baicalin affects the reaction [Rotenone results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
baicalin results in decreased expression of BCL2 protein
baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]

PMID:25423838 PMID:31021006 PMID:34333357 PMID:36446982

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions

baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein]
baicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]

PMID:25423838 PMID:31021006 PMID:34333357 PMID:36446982

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

multiple interactions

baicalin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cyclin A2

decreases expression

baicalin results in decreased expression of CCNA2 protein

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin D1

increases expression
decreases expression
multiple interactions

baicalin results in increased expression of CCND1 mRNA
baicalin results in decreased expression of CCND1 protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]

PMID:19160421 PMID:21457722

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

collagen type I alpha 2 chain

multiple interactions

baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions
increases expression

3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein

PMID:18451504 PMID:26204831

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions
increases expression

3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

epidermal growth factor

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

ETS transcription factor ELK1

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr X:47,635,520...47,650,604
Ensembl chr X:47,635,521...47,650,604

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

forkhead box A2

decreases expression

baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein

NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,580,998...22,585,455

G

glutamic-oxaloacetic transaminase 1

multiple interactions

baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624

G

glutamic--pyruvic transaminase

multiple interactions

baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

hes family bHLH transcription factor 1

increases expression
multiple interactions

baicalin results in increased expression of HES1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]

NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732

G

hes related family bHLH transcription factor with YRPW motif 1

increases expression
multiple interactions

baicalin results in increased expression of HEY1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]

NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857

G

hes related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]

NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269

G

heme oxygenase 1

multiple interactions
increases expression

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HMOX1 protein]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]
baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein

PMID:16824337 PMID:18187930 PMID:38016618

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

HNF1 homeobox A

decreases expression
multiple interactions

baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]

NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512

G

hepatocyte nuclear factor 4 alpha

decreases expression
multiple interactions

baicalin results in decreased expression of HNF4A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]
baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein

NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845

G

heat shock protein family B (small) member 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein]

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295

G

interleukin 1 beta

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]
baicalin inhibits the reaction [Rotenone results in increased expression of IL1B protein]

PMID:29031535 PMID:36446982 PMID:38016618

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

decreases expression
multiple interactions

baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]

PMID:22019745 PMID:29031535 PMID:34333357 PMID:38016618

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

INS-IGF2 readthrough

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

G

kelch like ECH associated protein 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

mitogen-activated protein kinase 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

MYD88 innate immune signal transduction adaptor

decreases expression

baicalin results in decreased expression of MYD88 protein

NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024

G

NFE2 like bZIP transcription factor 2

multiple interactions

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NFKB inhibitor alpha

increases expression

baicalin results in increased expression of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NLR family pyrin domain containing 3

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]

PMID:29031535 PMID:38016618

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

nitric oxide synthase 2

multiple interactions
decreases expression

baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]

PMID:18187930 PMID:22019745 PMID:24312512

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch receptor 1

increases activity
increases expression

baicalin results in increased activity of NOTCH1 protein
baicalin results in increased expression of NOTCH1 mRNA

NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048

G

nuclear receptor subfamily 1 group H member 3

increases expression

Baicalin increases expression of NR1H3 mRNA and protein in foam cells

RGD

NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033

G

pyruvate kinase M1/2

increases activity

baicalin results in increased activity of PKM protein

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

peroxisome proliferator activated receptor gamma

multiple interactions

baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

proline rich membrane anchor 1

increases expression

baicalin results in increased expression of PRIMA1 mRNA

NCBI chr14:93,718,298...93,788,994
Ensembl chr14:93,718,298...93,788,485

G

prostaglandin-endoperoxide synthase 2

decreases expression

baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

PYD and CARD domain containing

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]

NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

baicalin affects the localization of and results in decreased expression of RELA protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RELA protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

PMID:22019745 PMID:34333357 PMID:38016618

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

synuclein alpha

multiple interactions

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315

G

TEK receptor tyrosine kinase

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of TEK mRNA]

NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174

G

transcription factor A, mitochondrial

multiple interactions
decreases expression

baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]
baicalin results in decreased expression of TFAM mRNA

NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220

G

transforming growth factor beta 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of TGFB1 mRNA]; baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

PMID:19474275 PMID:34414639

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tyrosine hydroxylase

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TH protein]

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

toll like receptor 4

decreases expression
multiple interactions

baicalin results in decreased expression of TLR4 protein
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TLR4 protein]
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

PMID:22019745 PMID:24312512 PMID:34333357

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions
decreases expression

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein
baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]

PMID:16824337 PMID:18187930 PMID:22019745 PMID:34333357 PMID:38016618

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

increases expression

baicalin results in increased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

thioredoxin interacting protein

multiple interactions

baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]

NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579

G

ubiquitin specific peptidase 27 X-linked

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased expression of USP27X protein]

NCBI chr X:49,879,484...49,882,558
Ensembl chr X:49,879,484...49,882,558

G

vascular endothelial growth factor C

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of VEGFC mRNA]

NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922

G

xanthine dehydrogenase

multiple interactions

baicalin inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

benserazide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of Benserazide

NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975

G

dopa decarboxylase

multiple interactions

Benserazide binds to and results in decreased activity of DDC protein

NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405

G

dopamine receptor D1

multiple interactions

[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]

NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182

G

dopamine receptor D2

multiple interactions

[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]

NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691

carbidopa

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]

PMID:34560070 PMID:35202708

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

PMID:34560070 PMID:35202708

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]

PMID:34560070 PMID:35202708

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]

PMID:34560070 PMID:35202708

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of Carbidopa

NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975

G

dopa decarboxylase

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]
Carbidopa binds to and results in decreased activity of DDC protein

PMID:35151785 PMID:35202708

NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405

G

dynamin 1 like

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

fission, mitochondrial 1

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]

NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316

G

glutamic--pyruvic transaminase

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

interleukin 1 beta

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

monoamine oxidase A

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]

PMID:34560070 PMID:35202708

NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817

G

mitofusin 1

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]

NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936

G

mitochondrially encoded ATP synthase membrane subunit 6

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]

NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207

G

mitochondrially encoded cytochrome b

multiple interactions

Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]

NCBI chr MT:14,747...15,887
Ensembl chr MT:14,747...15,887

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]

NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

signal transducer and activator of transcription 3

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

tumor necrosis factor

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of TNF protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tryptophan hydroxylase 1

multiple interactions

[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]

NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269

herbacetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fatty acid synthase

multiple interactions

herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein]

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

glucose-6-phosphate dehydrogenase

multiple interactions

herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein]

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

glutamic--pyruvic transaminase

multiple interactions

herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

sterol regulatory element binding transcription factor 1

multiple interactions

herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

sterol regulatory element binding transcription factor 2

multiple interactions

herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26041
role	25957
biological role	25936
biochemical role	25170
enzyme inhibitor	22355
EC 4.* (lyase) inhibitor	8189
EC 4.1.* (C-C lyase) inhibitor	173
EC 4.1.1.* (carboxy-lyase) inhibitor	173
EC 4.1.1.15 (glutamate decarboxylase) inhibitor +	0
EC 4.1.1.17 (ornithine decarboxylase) inhibitor +	160
EC 4.1.1.19 (arginine decarboxylase) inhibitor +	0
EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor +	0
EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor +	21
EC 4.1.1.39 (ribulose-bisphosphate carboxylase) inhibitor +	0
EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor +	0
EC 4.1.2.* (aldehyde-lyase) inhibitor +	0

paths to the root