Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
go back to main search page
Accession:CHEBI:76881 term browser browse the term
Definition:An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*).
Synonyms:related_synonym: EC 2.7.1.* inhibitor;   EC 2.7.1.* inhibitors;   phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors



show annotations for term's descendants           Sort by:
1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions
decreases activity
EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
JBrowse link
G ENPEP glutamyl aminopeptidase multiple interactions EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein] CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole affects the phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:16239170 PMID:31744678
G CCL2 chemokine (C-C motif) ligand 2 decreases expression
multiple interactions
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCL2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]
CTD PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with etoxazole] results in increased phosphorylation of MAPK1 protein CTD PMID:31744678 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with etoxazole] results in increased phosphorylation of MAPK3 protein CTD PMID:31744678 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole results in increased phosphorylation of MAPK8 protein] CTD PMID:31744678 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein] CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole affects the phosphorylation of RPS6 protein] CTD PMID:31744678 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein] CTD PMID:31744678 NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
pioglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression
affects localization
EXP Pioglitazone results in increased expression of ABCA1 mRNA
Pioglitazone affects the localization of ABCA1 protein
CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions
increases secretion
EXP Pioglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
Pioglitazone results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
JBrowse link
G CLDN3 claudin 3 multiple interactions EXP Pioglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein] CTD PMID:36596350 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
JBrowse link
G CLDN4 claudin 4 multiple interactions EXP Pioglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein] CTD PMID:36596350 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Pioglitazone results in decreased expression of LIPG mRNA; Pioglitazone results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,874
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein] CTD PMID:17065204 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein] CTD PMID:17065204 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases activity
EXP Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein] CTD PMID:17065204 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G SCARB1 scavenger receptor class B member 1 increases expression
affects localization
EXP Pioglitazone results in increased expression of SCARB1 mRNA
Pioglitazone affects the localization of SCARB1 protein
CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
JBrowse link
wortmannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:16239170
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein] CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation
multiple interactions
EXP Wortmannin results in decreased phosphorylation of RPS6 protein
Wortmannin promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6 protein]
CTD PMID:31400776 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      biological role 5030
        biochemical role 4951
          enzyme inhibitor 493
            EC 2.* (transferase) inhibitor 143
              EC 2.7.* (P-containing group transferase) inhibitor 101
                EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor 21
                  EC 2.7.1.1 (hexokinase) inhibitor + 2
                  EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor + 0
                  EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor + 0
                  EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor + 11
                  EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor + 0
                  EC 2.7.1.153 (phosphatidylinositol-4,5-bisphosphate 3-kinase) inhibitor + 0
                  EC 2.7.1.33 (pantothenate kinase) inhibitor + 10
                  EC 2.7.1.40 (pyruvate kinase) inhibitor + 0
                  EC 2.7.1.91 (sphingosine kinase) inhibitor + 0
                  inositol phosphorylceramide synthase inhibitor + 0
paths to the root