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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
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Accession:CHEBI:76881 term browser browse the term
Definition:An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*).
Synonyms:related_synonym: EC 2.7.1.* inhibitor;   EC 2.7.1.* inhibitors;   phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors



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1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases expression EXP 1,10-phenanthroline results in decreased expression of ACE mRNA CTD PMID:19502547 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G AHR aryl hydrocarbon receptor decreases activity
multiple interactions
ISO
EXP
1,10-phenanthroline results in decreased activity of AHR protein
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Zinc inhibits the reaction [1,10-phenanthroline results in decreased activity of AHR protein]
CTD PMID:1322109 PMID:2160969 PMID:27180721 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AK1 adenylate kinase 1 decreases expression EXP 1,10-phenanthroline results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 9:127,866,480...127,879,621
Ensembl chr 9:127,866,486...127,877,675
JBrowse link
G AKAP9 A-kinase anchoring protein 9 increases expression EXP 1,10-phenanthroline results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 7:91,940,862...92,110,673
Ensembl chr 7:91,940,840...92,110,673
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 decreases activity EXP 1,10-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:8573067 PMID:12604236 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 decreases activity EXP 1,10-phenanthroline results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP 1,10-phenanthroline results in decreased activity of AKR1C3 protein CTD PMID:12604236 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 decreases activity EXP 1,10-phenanthroline results in decreased activity of AKR1C4 protein CTD PMID:12604236 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949
JBrowse link
G ALDOA aldolase, fructose-bisphosphate A increases expression EXP 1,10-phenanthroline results in increased expression of ALDOA mRNA CTD PMID:19502547 NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457
JBrowse link
G ALDOC aldolase, fructose-bisphosphate C increases expression EXP 1,10-phenanthroline results in increased expression of ALDOC mRNA CTD PMID:19502547 NCBI chr17:28,573,120...28,576,895
Ensembl chr17:28,573,115...28,576,948
JBrowse link
G ANKRD37 ankyrin repeat domain 37 increases expression EXP 1,10-phenanthroline results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr 4:185,396,841...185,400,723
Ensembl chr 4:185,396,021...185,400,628
JBrowse link
G ANPEP alanyl aminopeptidase, membrane decreases activity
multiple interactions
EXP 1,10-phenanthroline results in decreased activity of ANPEP protein
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]
CTD PMID:17109655 NCBI chr15:89,784,895...89,814,852
Ensembl chr15:89,784,895...89,815,401
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) decreases expression EXP 1,10-phenanthroline results in decreased expression of AQP3 mRNA CTD PMID:19641517 NCBI chr 9:33,441,160...33,447,593
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G ASPA aspartoacylase decreases activity EXP 1,10-phenanthroline results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr17:3,474,110...3,503,405
Ensembl chr17:3,472,374...3,503,405
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein CTD PMID:21355074 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
G BNIP3L BCL2 interacting protein 3 like decreases expression EXP 1,10-phenanthroline results in decreased expression of BNIP3L mRNA CTD PMID:19502547 NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636
JBrowse link
G CA9 carbonic anhydrase 9 increases expression EXP 1,10-phenanthroline results in increased expression of CA9 mRNA CTD PMID:19502547 NCBI chr 9:35,673,928...35,681,159
Ensembl chr 9:35,673,928...35,681,159
JBrowse link
G CAT catalase decreases expression EXP 1,10-phenanthroline results in decreased expression of CAT mRNA CTD PMID:19502547 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CD83 CD83 molecule increases expression EXP 1,10-phenanthroline results in increased expression of CD83 mRNA CTD PMID:19641517 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918
JBrowse link
G CD86 CD86 molecule increases expression
multiple interactions
EXP 1,10-phenanthroline results in increased expression of CD86 mRNA
Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]
CTD PMID:19641517 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CFTR CF transmembrane conductance regulator increases activity EXP 1,10-phenanthroline results in increased activity of CFTR protein CTD PMID:15921678 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP 1,10-phenanthroline results in increased expression of CXCL8 mRNA CTD PMID:19641517 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases stability
ISO
EXP
1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
1,10-phenanthroline results in increased stability of CYP1A1 mRNA
CTD PMID:1322109 PMID:19896525 PMID:27180721 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 increases expression EXP 1,10-phenanthroline results in increased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr 1:231,363,756...231,422,287
Ensembl chr 1:231,363,751...231,422,287
JBrowse link
G EGLN2 egl-9 family hypoxia inducible factor 2 decreases expression EXP 1,10-phenanthroline results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr19:40,799,191...40,808,434
Ensembl chr19:40,798,996...40,808,434
JBrowse link
G EGR1 early growth response 1 increases expression EXP 1,10-phenanthroline results in increased expression of EGR1 mRNA CTD PMID:19502547 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ENO1 enolase 1 increases expression EXP 1,10-phenanthroline results in increased expression of ENO1 mRNA CTD PMID:19502547 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G ENO2 enolase 2 increases expression EXP 1,10-phenanthroline results in increased expression of ENO2 mRNA CTD PMID:19502547 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression EXP 1,10-phenanthroline results in decreased expression of ERCC2 mRNA CTD PMID:19502547 NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase increases expression EXP 1,10-phenanthroline results in increased expression of GAPDH mRNA CTD PMID:19502547 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GPX3 glutathione peroxidase 3 decreases expression EXP 1,10-phenanthroline results in decreased expression of GPX3 mRNA CTD PMID:19502547 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP [Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AX protein modified form CTD PMID:22659117 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
JBrowse link
G HAMP hepcidin antimicrobial peptide decreases expression EXP 1,10-phenanthroline results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
JBrowse link
G HBEGF heparin binding EGF like growth factor increases expression EXP 1,10-phenanthroline results in increased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
EXP
ISO
4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]
1,10-phenanthroline results in increased activity of HIF1A protein
CTD PMID:19091749 PMID:19502547 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HIF3A hypoxia inducible factor 3 subunit alpha decreases expression EXP 1,10-phenanthroline results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr19:46,297,042...46,343,433
Ensembl chr19:46,297,042...46,343,433
JBrowse link
G HILPDA hypoxia inducible lipid droplet associated increases expression EXP 1,10-phenanthroline results in increased expression of HILPDA mRNA CTD PMID:19502547 NCBI chr 7:128,455,878...128,458,418
Ensembl chr 7:128,455,849...128,458,418
JBrowse link
G HK1 hexokinase 1 increases expression EXP 1,10-phenanthroline results in increased expression of HK1 mRNA CTD PMID:19502547 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884
JBrowse link
G HK2 hexokinase 2 increases expression EXP 1,10-phenanthroline results in increased expression of HK2 mRNA CTD PMID:19502547 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein]; 1,10-phenanthroline inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA] CTD PMID:9747510 PMID:15629867 PMID:20888885 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP 1,10-phenanthroline affects the reaction [Smoke results in increased expression of ICAM1 protein] CTD PMID:15560890 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 decreases degradation ISO 1,10-phenanthroline results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549
JBrowse link
G IL1R1 interleukin 1 receptor type 1 decreases expression EXP 1,10-phenanthroline results in decreased expression of IL1R1 mRNA CTD PMID:19502547 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G LAMC2 laminin subunit gamma 2 multiple interactions EXP 1,10-phenanthroline inhibits the reaction [Mustard Gas results in increased degradation of LAMC2 protein] CTD PMID:18095945 NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127
JBrowse link
G LDHA lactate dehydrogenase A increases expression EXP 1,10-phenanthroline results in increased expression of LDHA mRNA CTD PMID:19502547 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 multiple interactions EXP [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein CTD PMID:21355074 NCBI chr  X:21,839,617...21,885,423
Ensembl chr  X:21,839,617...21,885,423
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP 1,10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MIF macrophage migration inhibitory factor increases expression EXP 1,10-phenanthroline results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MMP8 matrix metallopeptidase 8 decreases activity EXP 1,10-phenanthroline results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
CTD PMID:20177776 PMID:20195827 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NLN neurolysin decreases activity ISO 1,10-phenanthroline decreases activity of Nln protein RGD PMID:7836437 RGD:9831155 NCBI chr 5:65,722,205...65,829,283
Ensembl chr 5:65,722,205...65,871,725
JBrowse link
G NPPB natriuretic peptide B increases expression EXP 1,10-phenanthroline results in increased expression of NPPB mRNA CTD PMID:19502547 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NUB1 negative regulator of ubiquitin like proteins 1 increases expression EXP 1,10-phenanthroline results in increased expression of NUB1 mRNA CTD PMID:19502547 NCBI chr 7:151,341,812...151,378,449
Ensembl chr 7:151,341,772...151,378,449
JBrowse link
G OCLN occludin multiple interactions EXP 1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein] CTD PMID:19013514 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
JBrowse link
G P4HA2 prolyl 4-hydroxylase subunit alpha 2 increases expression EXP 1,10-phenanthroline results in increased expression of P4HA2 mRNA CTD PMID:19502547 NCBI chr 5:132,190,147...132,227,853
Ensembl chr 5:132,190,147...132,295,315
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 increases expression EXP 1,10-phenanthroline results in increased expression of PDK1 mRNA CTD PMID:19502547 NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 increases expression EXP 1,10-phenanthroline results in increased expression of PDK3 mRNA CTD PMID:19502547 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,244...24,550,466
JBrowse link
G PGK1 phosphoglycerate kinase 1 increases expression EXP 1,10-phenanthroline results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:78,104,248...78,129,295
Ensembl chr  X:77,910,739...78,129,295
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions ISO 1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein] CTD PMID:20177776 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 increases expression EXP 1,10-phenanthroline results in increased expression of PLOD3 mRNA CTD PMID:19502547 NCBI chr 7:101,205,984...101,217,581
Ensembl chr 7:101,205,977...101,218,420
JBrowse link
G PPP2R1B protein phosphatase 2 scaffold subunit Abeta decreases expression EXP 1,10-phenanthroline results in decreased expression of PPP2R1B mRNA CTD PMID:19502547 NCBI chr11:111,688,000...111,766,389
Ensembl chr11:111,726,908...111,766,389
JBrowse link
G PSPH phosphoserine phosphatase decreases expression EXP 1,10-phenanthroline results in decreased expression of PSPH mRNA CTD PMID:19502547 NCBI chr 7:56,011,064...56,051,444
Ensembl chr 7:56,011,051...56,051,604
JBrowse link
G SELE selectin E multiple interactions EXP 1,10-phenanthroline affects the reaction [Smoke results in increased expression of SELE protein] CTD PMID:15560890 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SERPINE1 serpin family E member 1 increases expression EXP 1,10-phenanthroline results in increased expression of SERPINE1 mRNA CTD PMID:19502547 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein]; 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein] CTD PMID:15629867 PMID:20674559 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein] CTD PMID:20674559 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein CTD PMID:21355074 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide affects the localization of STAT3 protein] CTD PMID:10364193 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TFRC transferrin receptor increases expression EXP 1,10-phenanthroline results in increased expression of TFRC mRNA CTD PMID:19502547 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153
JBrowse link
G TIMM17A translocase of inner mitochondrial membrane 17A multiple interactions EXP 1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein] CTD PMID:24315374 NCBI chr 1:201,955,503...201,970,664
Ensembl chr 1:201,955,503...201,970,664
JBrowse link
G TP53 tumor protein p53 affects folding
affects activity
ISO
EXP
1,10-phenanthroline affects the folding of TRP53 protein
1,10-phenanthroline analog affects the activity of TP53 protein
CTD PMID:8467489 PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression
multiple interactions
EXP
ISO
1,10-phenanthroline results in increased expression of VEGFA mRNA; 1,10-phenanthroline results in increased expression of VEGFA protein
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]
CTD PMID:19502547 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
bathocuproine disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA] CTD PMID:15477007 NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902
JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ARHGDIA mRNA CTD PMID:15477007 NCBI chr17:81,867,721...81,871,337
Ensembl chr17:81,867,721...81,871,378
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA] CTD PMID:15477007 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
JBrowse link
G ATOX1 antioxidant 1 copper chaperone multiple interactions ISO ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] CTD PMID:20194531 NCBI chr 5:151,742,822...151,758,631
Ensembl chr 5:151,742,316...151,772,532
JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions EXP [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 PMID:21242307 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions EXP [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr13:51,932,669...52,012,132
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP bathocuproine sulfonate results in decreased expression of BCL2 protein CTD PMID:24614111 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]] CTD PMID:15477007 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G CASP3 caspase 3 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of CASP3 protein] CTD PMID:10941151 PMID:11239917 PMID:18056745 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]] CTD PMID:15477007 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:11006087 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL3 mRNA] CTD PMID:15477007 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL3L1 C-C motif chemokine ligand 3 like 1 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL3L1 mRNA] CTD PMID:15477007 Ensembl chr17:36,194,869...36,196,758 JBrowse link
G CCT5 chaperonin containing TCP1 subunit 5 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]] CTD PMID:15477007 NCBI chr 5:10,249,921...10,266,412
Ensembl chr 5:10,249,929...10,266,389
JBrowse link
G CD200 CD200 molecule multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA] CTD PMID:15477007 NCBI chr 3:112,332,573...112,362,812
Ensembl chr 3:112,332,347...112,362,812
JBrowse link
G CD44 CD44 molecule (IN blood group) multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA] CTD PMID:15477007 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CDH17 cadherin 17 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDH17 mRNA]; [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CDH17 mRNA CTD PMID:15477007 NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303
JBrowse link
G CLU clusterin multiple interactions EXP [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G CNTNAP1 contactin associated protein 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CNTNAP1 mRNA CTD PMID:15477007 NCBI chr17:42,682,531...42,699,993
Ensembl chr17:42,682,531...42,699,993
JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CP ceruloplasmin multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein] CTD PMID:17032174 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CPSF1 cleavage and polyadenylation specific factor 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CPSF1 mRNA CTD PMID:15477007 NCBI chr 8:144,393,231...144,409,335
Ensembl chr 8:144,393,229...144,409,335
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CREB1 mRNA CTD PMID:15477007 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREM cAMP responsive element modulator multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA] CTD PMID:15477007 NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CUL5 cullin 5 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] CTD PMID:15477007 NCBI chr11:108,008,898...108,107,761
Ensembl chr11:108,008,898...108,107,761
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which affects the localization of CYCS protein] CTD PMID:18056745 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of DNAJB1 mRNA CTD PMID:15477007 NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,514,769...14,560,391
JBrowse link
G DUSP4 dual specificity phosphatase 4 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]] CTD PMID:15477007 NCBI chr 8:29,333,064...29,350,684
Ensembl chr 8:29,333,064...29,350,684
JBrowse link
G EGR2 early growth response 2 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA] CTD PMID:15477007 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167
JBrowse link
G EGR3 early growth response 3 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of EGR3 mRNA CTD PMID:15477007 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480
JBrowse link
G FASN fatty acid synthase multiple interactions EXP bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of FASN mRNA] CTD PMID:24170205 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:22842628 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOS protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]] CTD PMID:15477007 PMID:17032174 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FYB1 FYN binding protein 1 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA] CTD PMID:15477007 NCBI chr 5:39,105,252...39,274,528
Ensembl chr 5:39,105,252...39,274,528
JBrowse link
G GFRA2 GDNF family receptor alpha 2 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GFRA2 mRNA] CTD PMID:15477007 NCBI chr 8:21,690,398...21,812,345
Ensembl chr 8:21,690,398...21,812,357
JBrowse link
G GNAS GNAS complex locus multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GNAS mRNA CTD PMID:15477007 NCBI chr20:58,839,748...58,911,192
Ensembl chr20:58,839,718...58,911,192
JBrowse link
G GNLY granulysin multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GNLY mRNA] CTD PMID:15477007 NCBI chr 2:85,694,358...85,698,852
Ensembl chr 2:85,685,175...85,698,852
JBrowse link
G GTF2H2C GTF2H2 family member C multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GTF2H2C mRNA CTD PMID:15477007 NCBI chr 5:69,560,191...69,595,221
Ensembl chr 5:69,560,191...69,595,221
Ensembl chr 5:69,560,191...69,595,221
JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HADHA mRNA] CTD PMID:15477007 NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672
JBrowse link
G HCK HCK proto-oncogene, Src family tyrosine kinase multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA] CTD PMID:15477007 NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein CTD PMID:21242307 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HNRNPUL1 mRNA CTD PMID:15477007 NCBI chr19:41,262,557...41,307,787
Ensembl chr19:41,262,496...41,307,787
JBrowse link
G HPX hemopexin multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HSPA8 mRNA; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA8 mRNA]] CTD PMID:15477007 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230
JBrowse link
G HYAL3 hyaluronidase 3 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HYAL3 mRNA CTD PMID:15477007 NCBI chr 3:50,292,832...50,299,405
Ensembl chr 3:50,292,831...50,299,405
JBrowse link
G IL2 interleukin 2 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]] CTD PMID:15477007 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha multiple interactions ISO bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]] CTD PMID:23134680 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL2RB interleukin 2 receptor subunit beta multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RB mRNA] CTD PMID:15477007 NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,118,666...37,175,118
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN protein]] CTD PMID:15477007 PMID:17032174 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G LCP1 lymphocyte cytosolic protein 1 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA] CTD PMID:15477007 NCBI chr13:46,125,923...46,182,177
Ensembl chr13:46,125,920...46,211,871
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions EXP bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of LDLR mRNA] CTD PMID:24170205 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820
JBrowse link
G LTBP4 latent transforming growth factor beta binding protein 4 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA] CTD PMID:15477007 NCBI chr19:40,593,166...40,629,820
Ensembl chr19:40,592,883...40,629,818
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK1 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]
CTD PMID:10658192 PMID:15477007 PMID:22842628 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK3 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK3 protein]
CTD PMID:10941151 PMID:15477007 PMID:22842628 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK8 protein] CTD PMID:10941151 PMID:11239917 PMID:18056745 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MT1B metallothionein 1B multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1B mRNA CTD PMID:15477007 NCBI chr16:56,651,886...56,653,204
Ensembl chr16:56,651,886...56,653,204
JBrowse link
G MT1E metallothionein 1E multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1E mRNA CTD PMID:15477007 NCBI chr16:56,625,781...56,627,112
Ensembl chr16:56,625,475...56,627,112
JBrowse link
G MT1F metallothionein 1F multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1F mRNA CTD PMID:15477007 NCBI chr16:56,657,959...56,659,303
Ensembl chr16:56,657,731...56,660,698
JBrowse link
G MT1G metallothionein 1G multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1G mRNA CTD PMID:15477007 NCBI chr16:56,666,730...56,668,065
Ensembl chr16:56,666,730...56,668,065
JBrowse link
G MT1H metallothionein 1H multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1H mRNA CTD PMID:15477007 NCBI chr16:56,669,814...56,671,129
Ensembl chr16:56,669,814...56,671,129
JBrowse link
G MT1X metallothionein 1X multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1X mRNA CTD PMID:15477007 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MTA1 metastasis associated 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MTA1 mRNA CTD PMID:15477007 NCBI chr14:105,419,827...105,470,729
Ensembl chr14:105,419,820...105,470,729
JBrowse link
G MTF1 metal regulatory transcription factor 1 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 1:37,809,574...37,859,592
Ensembl chr 1:37,809,574...37,859,592
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MYC mRNA] CTD PMID:15477007 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NAA80 mRNA] CTD PMID:15477007 NCBI chr 3:50,296,402...50,299,405
Ensembl chr 3:50,296,402...50,299,416
JBrowse link
G NELL1 neural EGFL like 1 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA] CTD PMID:15477007 NCBI chr11:20,669,551...21,575,686
Ensembl chr11:20,669,551...21,575,686
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of NFE2L2 mRNA CTD PMID:15477007 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] CTD PMID:11006087 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] CTD PMID:11006087 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NMI N-myc and STAT interactor multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NMI mRNA] CTD PMID:15477007 NCBI chr 2:151,270,470...151,289,668
Ensembl chr 2:151,270,470...151,289,894
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NR4A3 mRNA] CTD PMID:15477007 NCBI chr 9:99,821,885...99,866,891
Ensembl chr 9:99,821,855...99,866,891
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ODC1 mRNA CTD PMID:15477007 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G PAX8 paired box 8 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA] CTD PMID:11108245 NCBI chr 2:113,215,997...113,278,921
Ensembl chr 2:113,215,997...113,278,921
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP bathocuproine sulfonate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PPP1R10 protein phosphatase 1 regulatory subunit 10 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of PPP1R10 mRNA CTD PMID:15477007 NCBI chr 6:30,600,413...30,617,243
Ensembl chr 6:30,600,413...30,618,612
JBrowse link
G PRNP prion protein (Kanno blood group) multiple interactions ISO bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590
JBrowse link
G REL REL proto-oncogene, NF-kB subunit multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA] CTD PMID:15477007 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612
JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 increases oxidation EXP bathocuproine sulfonate results in increased oxidation of SCO1 protein CTD PMID:23345593 NCBI chr17:10,672,474...10,697,533
Ensembl chr17:10,672,474...10,698,375
JBrowse link
G SLA Src like adaptor multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLA mRNA] CTD PMID:15477007 NCBI chr 8:133,036,728...133,102,602
Ensembl chr 8:133,036,728...133,102,912
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions EXP [bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA; bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC31A2 solute carrier family 31 member 2 multiple interactions
affects localization
EXP
ISO
[[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] which results in increased uptake of and results in increased susceptibility to Cisplatin; [bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein
bathocuproine sulfonate affects the localization of SLC31A2 protein
ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein]
CTD PMID:20194531 NCBI chr 9:113,151,007...113,164,140
Ensembl chr 9:113,150,976...113,164,140
JBrowse link
G SNRNP70 small nuclear ribonucleoprotein U1 subunit 70 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SNRNP70 mRNA CTD PMID:15477007 NCBI chr19:49,085,451...49,108,604
Ensembl chr19:49,085,419...49,108,605
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SOD1 mRNA CTD PMID:15477007 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SRGN serglycin multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SRGN mRNA CTD PMID:15477007 NCBI chr10:69,087,603...69,104,811
Ensembl chr10:69,088,103...69,104,805
JBrowse link
G SRPRA SRP receptor subunit alpha multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRPRA mRNA] CTD PMID:15477007 NCBI chr11:126,235,930...126,268,895
Ensembl chr11:126,262,938...126,269,144
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:11006087 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA] CTD PMID:15477007 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid results in increased abundance of Copper] which results in increased oxidation of and results in increased expression of TP53 protein] CTD PMID:11964141 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPO thyroid peroxidase multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA] CTD PMID:11108245 NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711
JBrowse link
G TRAF1 TNF receptor associated factor 1 multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]] CTD PMID:15477007 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173
JBrowse link
G TYR tyrosinase multiple interactions EXP bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TYROBP mRNA] CTD PMID:15477007 NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295
JBrowse link
G UBE2L6 ubiquitin conjugating enzyme E2 L6 multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBE2L6 mRNA CTD PMID:15477007 NCBI chr11:57,551,662...57,567,935
Ensembl chr11:57,551,656...57,568,284
JBrowse link
G UBL4A ubiquitin like 4A multiple interactions EXP [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBL4A mRNA CTD PMID:15477007 NCBI chr  X:154,483,717...154,486,615
Ensembl chr  X:154,483,717...154,486,615
JBrowse link
G VIM vimentin multiple interactions EXP [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VIM mRNA] CTD PMID:15477007 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
BKM120 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 decreases expression ISO BKM120 decreases expression of cyclin E protein in rat pituitary tumor cell line RGD PMID:26983879 RGD:152177690 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G PRL prolactin decreases expression ISO BKM120 decreases expression of prolactin protein in serum of treated rats RGD PMID:26983879 RGD:152177690 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G FAS Fas cell surface death receptor affects response to substance EXP copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G TNF tumor necrosis factor increases response to substance EXP copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
corilagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIF1 allograft inflammatory factor 1 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]] CTD PMID:37394652 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
ISO
EXP
corilagin inhibits the reaction [Doxorubicin results in increased expression of AKT1 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA]
corilagin results in decreased expression of AKT1 protein
CTD PMID:34369273 PMID:34605098 PMID:35084093 PMID:35103375 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]] CTD PMID:37394652 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein] CTD PMID:34605098 PMID:35103375 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein] CTD PMID:34605098 PMID:35103375 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BSG basigin (Ok blood group) multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA] CTD PMID:35103375 NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494
JBrowse link
G CASP3 caspase 3 multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]
CTD PMID:34605098 PMID:35103375 PMID:37394652 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein] CTD PMID:35103375 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein]; corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]
CTD PMID:30582900 PMID:34605098 PMID:35103375 PMID:35307913 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]] CTD PMID:37394652 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
JBrowse link
G FABP3 fatty acid binding protein 3 multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein] CTD PMID:34369273 NCBI chr 1:31,359,588...31,373,076
Ensembl chr 1:31,365,253...31,376,850
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] CTD PMID:35307913 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [corilagin co-treated with TNFSF11 protein] results in increased expression of GSR mRNA CTD PMID:35307913 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA] CTD PMID:35103375 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA] CTD PMID:35103375 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased activity of HMGCR protein] CTD PMID:34605098 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]] CTD PMID:35307913 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]] CTD PMID:37394652 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]] CTD PMID:37394652 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
corilagin inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
corilagin results in decreased expression of IL6 protein
CTD PMID:34369273 PMID:34605098 PMID:35084093 PMID:37394652 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO corilagin inhibits the reaction [Streptozocin results in increased secretion of INS1 protein] CTD PMID:30582900 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of LDHA mRNA] CTD PMID:35103375 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G MB myoglobin multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of MB protein] CTD PMID:34369273 NCBI chr22:35,606,764...35,623,354
Ensembl chr22:35,606,764...35,637,951
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:35307913 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA] CTD PMID:35307913 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression EXP corilagin results in decreased expression of NFKB1 protein CTD PMID:35084093 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]] CTD PMID:37394652 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
corilagin results in decreased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]
CTD PMID:35084093 PMID:37394652 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:34369273 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions ISO corilagin inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; corilagin increases expression of nr1h4 mRNA and protein in rat embryonic liver cells RGD PMID:29235094 RGD:15042872 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA] CTD PMID:35103375 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of PPARG protein] CTD PMID:34605098 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
corilagin results in decreased expression of PTGS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]
CTD PMID:35084093 PMID:37394652 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]] CTD PMID:37394652 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G SLC16A3 solute carrier family 16 member 3 multiple interactions ISO corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA] CTD PMID:35103375 NCBI chr17:82,217,934...82,240,086
Ensembl chr17:82,217,934...82,261,129
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:34369273 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TLR2 toll like receptor 2 multiple interactions ISO corilagin inhibits the reaction [Morphine results in increased expression of TLR2 mRNA]; corilagin inhibits the reaction [Morphine results in increased expression of TLR2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TNF tumor necrosis factor decreases secretion
multiple interactions
decreases expression
ISO
EXP
corilagin results in decreased secretion of TNF protein
corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]
corilagin results in decreased expression of TNF protein
corilagin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
CTD PMID:12628509 PMID:34369273 PMID:34605098 PMID:35084093 PMID:37394652 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO [corilagin co-treated with TNFSF11 protein] results in increased expression of GSR mRNA; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; tin protoporphyrin IX inhibits the reaction [corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]] CTD PMID:35307913 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO corilagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:34369273 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
dactolisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions
EXP
ISO
dactolisib results in decreased expression of AKT1 protein modified form
dactolisib increases phosphorylation of Akt in rat tumor grafts
dactolisib results in decreased phosphorylation of AKT1 protein
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
CTD
RGD
PMID:19435893 PMID:21464613 PMID:22415236 PMID:22949526 PMID:23151917 More... RGD:152177690 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib affects the folding of and results in increased activity of BAX protein; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein] CTD PMID:23151917 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2L1 BCL2 like 1 affects expression EXP dactolisib affects the expression of BCL2L1 protein CTD PMID:25640480 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 affects expression EXP dactolisib affects the expression of BCL2L11 protein CTD PMID:25640480 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP dactolisib results in decreased expression of BIRC5 protein CTD PMID:22729845 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 increases activity
increases cleavage
multiple interactions
EXP dactolisib results in increased activity of CASP3 protein
dactolisib results in increased cleavage of CASP3 protein
Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]
CTD PMID:21372221 PMID:23151917 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions
increases cleavage
EXP Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCND1 cyclin D1 decreases phosphorylation EXP dactolisib results in decreased phosphorylation of CCND1 protein CTD PMID:23651616 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP dactolisib results in increased expression of CDKN1A protein CTD PMID:23651616 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CTSB cathepsin B affects localization
multiple interactions
EXP dactolisib affects the localization of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein
CTD PMID:23151917 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G EGF epidermal growth factor multiple interactions EXP dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:24758408 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
increases response to substance
EXP dactolisib results in decreased phosphorylation of EIF4EBP1 protein
Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]
EIF4EBP1 protein modified form results in increased susceptibility to dactolisib
CTD PMID:21372221 PMID:22415236 PMID:23151917 PMID:25640480 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G HSF1 heat shock transcription factor 1 decreases activity EXP dactolisib results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein] CTD PMID:22949526 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G LEPR leptin receptor multiple interactions ISO LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] CTD PMID:22949526 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases metabolic processing
affects localization
EXP dactolisib results in increased metabolism of MAP1LC3A protein
dactolisib affects the localization of MAP1LC3A protein
CTD PMID:23651616 NCBI chr20:34,546,844...34,560,345
Ensembl chr20:34,546,854...34,560,345
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:22415236 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22415236 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member affects expression
multiple interactions
EXP dactolisib affects the expression of MCL1 protein
[dactolisib co-treated with (+)-JQ1 compound] affects the expression of MCL1 protein
CTD PMID:25640480 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase increases response to substance EXP OGT mutant form results in increased susceptibility to dactolisib CTD PMID:23029544 NCBI chr  X:71,533,104...71,575,892
Ensembl chr  X:71,533,087...71,575,892
JBrowse link
G OXSR1 oxidative stress responsive kinase 1 multiple interactions
decreases phosphorylation
ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]
dactolisib results in decreased phosphorylation of OXSR1 protein
CTD PMID:22949526 NCBI chr 3:38,164,063...38,255,484
Ensembl chr 3:38,165,089...38,255,484
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP dactolisib results in increased cleavage of PARP1 protein CTD PMID:21464613 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha increases response to substance
decreases response to substance
EXP PIK3CA results in increased susceptibility to dactolisib
PIK3CA results in decreased susceptibility to dactolisib
CTD PMID:21372221 PMID:21633166 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PTEN phosphatase and tensin homolog increases response to substance EXP PTEN gene mutant form results in increased susceptibility to dactolisib CTD PMID:21372221 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP dactolisib results in decreased expression of RB1 protein modified form CTD PMID:23651616 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions
decreases phosphorylation
EXP mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein] CTD PMID:21372221 PMID:21464613 PMID:21498705 PMID:22415236 PMID:23151917 More... NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases phosphorylation EXP dactolisib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21464613 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SLC12A3 solute carrier family 12 member 3 multiple interactions
decreases phosphorylation
ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]
dactolisib results in decreased phosphorylation of SLC12A3 protein
CTD PMID:22949526 NCBI chr16:56,865,207...56,915,850
Ensembl chr16:56,865,207...56,915,850
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein] CTD PMID:23151917 PMID:23651616 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G STK39 serine/threonine kinase 39 multiple interactions
decreases phosphorylation
ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]
dactolisib results in decreased phosphorylation of STK39 protein
CTD PMID:22949526 NCBI chr 2:167,954,022...168,247,595
Ensembl chr 2:167,954,020...168,247,595
JBrowse link
dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
EXP Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]
CTD PMID:8700121 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]
CTD PMID:16407456 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]
CTD PMID:16407456 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions
increases expression
ISO [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein
CTD PMID:25786523 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 multiple interactions ISO [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions ISO [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein CTD PMID:25786523 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects metabolic processing
multiple interactions
EXP
ISO
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein
CTD PMID:2271712 PMID:25786523 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 affects abundance
multiple interactions
increases oxidation
increases hydroxylation
EXP CYP3A7 promoter polymorphism affects the abundance of Dehydroepiandrosterone Sulfate
Ritonavir inhibits the reaction [CYP3A7 protein results in increased oxidation of Dehydroepiandrosterone Sulfate]
CYP3A7 protein results in increased hydroxylation of Dehydroepiandrosterone Sulfate
CTD PMID:15985487 PMID:33821626 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein
CTD PMID:8700121 PMID:25786523 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727
JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]
CTD PMID:8700121 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
CTD PMID:8700121 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases abundance
EXP Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] CTD PMID:12548226 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G NAT1 N-acetyltransferase 1 multiple interactions EXP Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance
ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate
CTD PMID:8700121 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PRL prolactin increases abundance EXP PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G SIRT1 sirtuin 1 increases expression ISO Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT6 sirtuin 6 increases expression ISO Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566
JBrowse link
G SLC10A6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr 4:86,823,468...86,849,384
Ensembl chr 4:86,823,468...86,849,384
JBrowse link
G SLC22A11 solute carrier family 22 member 11 affects transport EXP SLC22A11 protein affects the transport of Dehydroepiandrosterone Sulfate CTD PMID:10660625 NCBI chr11:64,555,941...64,572,875
Ensembl chr11:64,555,690...64,572,875
JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353
JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases transport EXP SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G SLC22A8 solute carrier family 22 member 8 affects transport
increases uptake
EXP SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate
CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G SLC22A9 solute carrier family 22 member 9 multiple interactions
affects transport
increases uptake
EXP
ISO
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
SLC22A19 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
CTD PMID:16079298 PMID:17132213 PMID:18441515 NCBI chr11:63,369,785...63,410,294
Ensembl chr11:63,369,785...63,410,294
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation ISO Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STS steroid sulfatase affects metabolic processing EXP STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:7,147,290...7,354,641
Ensembl chr  X:7,147,237...7,804,358
JBrowse link
ellagic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 increases expression EXP Ellagic Acid results in increased expression of ACP3 mRNA CTD PMID:12002526 NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:32971123 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases expression EXP Ellagic Acid results in increased expression of AIFM1 protein CTD PMID:23554011 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
Ellagic Acid results in increased phosphorylation of AKT1 protein
Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 protein]
CTD PMID:26986492 PMID:35236242 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin multiple interactions
affects binding
EXP ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein]
Ellagic Acid binds to ALB protein
CTD PMID:6343536 PMID:25247703 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALKBH2 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase decreases activity EXP Ellagic Acid results in decreased activity of ALKBH2 protein CTD PMID:31088072 NCBI chr12:109,088,189...109,093,472
Ensembl chr12:109,088,188...109,093,631
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 decreases expression
increases expression
EXP Ellagic Acid results in decreased expression of APAF1 mRNA
Ellagic Acid results in increased expression of APAF1 mRNA
CTD PMID:12002526 PMID:35179410 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Ellagic Acid inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:34944019 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 increases expression EXP Ellagic Acid results in increased expression of ASCL1 mRNA CTD PMID:12002526 NCBI chr12:102,957,674...102,960,513
Ensembl chr12:102,957,674...102,960,513
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Ellagic Acid results in increased expression of ASNS mRNA CTD PMID:12002526 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Ellagic Acid results in increased expression of ATF3 mRNA CTD PMID:12002526 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATG5 autophagy related 5 increases expression EXP Ellagic Acid results in increased expression of ATG5 mRNA CTD PMID:12002526 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP Ellagic Acid results in increased expression of BAD protein CTD PMID:23554011 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA]
Ellagic Acid results in increased expression of BAX mRNA
CTD PMID:29854611 PMID:35179410 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
decreases expression
multiple interactions
EXP
ISO
Ellagic Acid results in increased expression of BCL2 protein
Ellagic Acid results in decreased expression of BCL2 mRNA
Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]
[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]
CTD PMID:20103723 PMID:22386815 PMID:29854611 PMID:35179410 PMID:35236242 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BMP6 bone morphogenetic protein 6 decreases expression EXP Ellagic Acid results in decreased expression of BMP6 mRNA CTD PMID:12002526 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G BRF1 BRF1 RNA polymerase III transcription initiation factor subunit decreases expression EXP Ellagic Acid results in decreased expression of BRF1 mRNA CTD PMID:12002526 NCBI chr14:105,209,286...105,315,589
Ensembl chr14:105,209,286...105,315,589
JBrowse link
G CALR calreticulin decreases expression EXP Ellagic Acid results in decreased expression of CALR mRNA CTD PMID:12002526 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
increases activity
decreases activity
decreases expression
EXP
ISO
Ellagic Acid results in increased expression of CASP3 mRNA
Ellagic Acid inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased activity of CASP3 protein]
Ellagic Acid results in increased expression of and results in increased activity of CASP3 protein
Ellagic Acid results in increased activity of CASP3 protein
Ellagic Acid results in decreased activity of CASP3 protein
Ellagic Acid results in decreased expression of CASP3 mRNA
CTD PMID:12002526 PMID:22386815 PMID:23554011 PMID:23811531 PMID:28815802 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Ellagic Acid results in increased expression of and results in increased activity of CASP9 protein CTD PMID:23554011 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase increases activity
multiple interactions
ISO Ellagic Acid results in increased activity of CAT protein
Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [chromium hexavalent ion results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:20074268 PMID:24877639 PMID:29864931 PMID:35236242 PMID:36108929 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases secretion EXP Ellagic Acid results in decreased secretion of CCL2 protein CTD PMID:20816778 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCNG1 cyclin G1 decreases expression ISO ellagic acid inhibits the reaction [estrogen increases expression of Ccng1 mRNA and protein in rat mammary tissue] RGD PMID:23791885 RGD:151356928 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CD14 CD14 molecule decreases expression EXP Ellagic Acid results in decreased expression of CD14 mRNA CTD PMID:20816778 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP Ellagic Acid results in decreased expression of CDK1 protein CTD PMID:23554011 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
ISO
EXP
[resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]
[Ellagic Acid co-treated with Quercetin] results in increased expression of CDKN1A mRNA; Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]
Ellagic Acid results in increased expression of CDKN1A protein
CTD PMID:15735102 PMID:20103723 PMID:23554011 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CTSD cathepsin D multiple interactions ISO Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSK cathepsin K multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:32971123 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
EXP Ellagic Acid inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Ellagic Acid inhibits the reaction [TNF protein results in increased activity of and affects the secretion of CXCL8 protein]
Ellagic Acid results in decreased expression of CXCL8 mRNA
CTD PMID:18377686 PMID:27473819 PMID:35179410 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression
decreases activity
EXP
ISO
Ellagic Acid results in decreased expression of CYP1A1 mRNA
Ellagic Acid results in decreased activity of CYP1A1 protein
CTD PMID:19329757 PMID:20816778 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity
multiple interactions
ISO Ellagic Acid results in decreased activity of CYP1B1 protein
[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]
CTD PMID:19329757 PMID:20103723 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DAXX death domain associated protein decreases expression EXP Ellagic Acid results in decreased expression of DAXX mRNA CTD PMID:12002526 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016
JBrowse link
G DFFA DNA fragmentation factor subunit alpha decreases expression EXP Ellagic Acid results in decreased expression of DFFA mRNA CTD PMID:12002526 NCBI chr 1:10,456,522...10,472,529
Ensembl chr 1:10,456,522...10,472,529
JBrowse link
G E4F1 E4F transcription factor 1 increases expression EXP Ellagic Acid results in increased expression of E4F1 mRNA CTD PMID:12002526 NCBI chr16:2,223,591...2,235,742
Ensembl chr16:2,223,580...2,235,742
JBrowse link
G EGR3 early growth response 3 decreases expression EXP Ellagic Acid results in decreased expression of EGR3 mRNA CTD PMID:12002526 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480
JBrowse link
G ENDOG endonuclease G increases expression EXP Ellagic Acid results in increased expression of ENDOG protein CTD PMID:23554011 NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676
JBrowse link
G EP300 E1A binding protein p300 increases expression EXP Ellagic Acid results in increased expression of EP300 mRNA CTD PMID:12002526 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G EPS15 epidermal growth factor receptor pathway substrate 15 increases expression EXP Ellagic Acid results in increased expression of EPS15 mRNA CTD PMID:12002526 NCBI chr 1:51,354,263...51,519,266
Ensembl chr 1:51,354,263...51,519,328
JBrowse link
G EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit increases expression EXP Ellagic Acid results in increased expression of EZH1 mRNA CTD PMID:12002526 NCBI chr17:42,700,275...42,745,040
Ensembl chr17:42,700,275...42,745,049
JBrowse link
G F12 coagulation factor XII multiple interactions
increases activity
EXP ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein] CTD PMID:6343536 NCBI chr 5:177,402,141...177,409,564
Ensembl chr 5:177,402,133...177,416,583
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 decreases expression EXP Ellagic Acid results in decreased expression of FGFR1 mRNA CTD PMID:12002526 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
JBrowse link
G FLNA filamin A decreases expression EXP Ellagic Acid results in decreased expression of FLNA mRNA CTD PMID:12002526 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,634
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein] CTD PMID:24877639 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; [Ellagic Acid co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] CTD PMID:20103723 PMID:32971123 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase decreases activity EXP Ellagic Acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GAL galanin and GMAP prepropeptide multiple interactions ISO Ellagic Acid inhibits the reaction [phosalone results in increased activity of GAL protein] CTD PMID:27965107 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 decreases expression EXP Ellagic Acid results in decreased expression of GPLD1 mRNA CTD PMID:12002526 NCBI chr 6:24,423,969...24,495,287
Ensembl chr 6:24,424,565...24,495,205
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Ellagic Acid inhibits the reaction [Diquat results in increased activity of GPT protein]
CTD PMID:24877639 PMID:29935397 PMID:35268077 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
Ellagic Acid inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]
CTD PMID:29935397 PMID:35268077 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein] CTD PMID:24877639 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 increases expression EXP Ellagic Acid results in increased expression of GSTA4 mRNA CTD PMID:12002526 NCBI chr 6:52,977,953...52,995,284
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTT1 glutathione S-transferase theta 1 affects expression ISO Ellagic Acid affects the expression of GSTT1 protein CTD PMID:9855024
G GTF2E2 general transcription factor IIE subunit 2 increases expression EXP Ellagic Acid results in increased expression of GTF2E2 mRNA CTD PMID:12002526 NCBI chr 8:30,578,318...30,658,236
Ensembl chr 8:30,578,318...30,658,236
JBrowse link
G GTF2H4 general transcription factor IIH subunit 4 increases expression EXP Ellagic Acid results in increased expression of GTF2H4 mRNA CTD PMID:12002526 NCBI chr 6:30,908,207...30,914,106
Ensembl chr 6:30,908,207...30,914,106
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:21762681 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha decreases expression EXP Ellagic Acid results in decreased expression of HIF1A mRNA CTD PMID:12002526 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HLCS holocarboxylase synthetase decreases activity EXP Ellagic Acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr21:36,748,625...36,990,211
Ensembl chr21:36,748,626...36,990,236
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Ellagic Acid results in increased expression of HMOX1 mRNA; Ellagic Acid results in increased expression of HMOX1 protein
Ellagic Acid inhibits the reaction [Diquat results in decreased expression of HMOX1 mRNA]
[Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 protein
CTD PMID:22386815 PMID:23546295 PMID:35268077 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions ISO [Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]; [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene] CTD PMID:20103723 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
JBrowse link
G IER2 immediate early response 2 increases expression EXP Ellagic Acid results in increased expression of IER2 mRNA CTD PMID:12002526 NCBI chr19:13,150,411...13,154,911
Ensembl chr19:13,150,411...13,154,911
JBrowse link
G IFNG interferon gamma multiple interactions ISO Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IFNG mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IFNG protein] CTD PMID:29854611 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression EXP Ellagic Acid results in increased expression of IGFBP2 mRNA CTD PMID:12002526 NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436
JBrowse link
G IGFBP4 insulin like growth factor binding protein 4 decreases expression EXP Ellagic Acid results in decreased expression of IGFBP4 mRNA CTD PMID:12002526 NCBI chr17:40,443,450...40,457,725
Ensembl chr17:40,443,450...40,457,725
JBrowse link
G IL1B interleukin 1 beta decreases expression
multiple interactions
EXP
ISO
Ellagic Acid results in decreased expression of IL1B mRNA
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IL1B mRNA]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
Ellagic Acid inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
CTD PMID:18377686 PMID:20816778 PMID:21762681 PMID:24877639 PMID:27965107 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1R1 interleukin 1 receptor type 1 decreases expression EXP Ellagic Acid results in decreased expression of IL1R1 mRNA CTD PMID:20816778 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL6 protein] CTD PMID:21762681 PMID:24877639 PMID:27965107 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D increases expression EXP Ellagic Acid results in increased expression of INPP5D mRNA CTD PMID:12002526 NCBI chr 2:233,060,342...233,207,903
Ensembl chr 2:233,059,967...233,207,903
JBrowse link
G IQGAP2 IQ motif containing GTPase activating protein 2 increases expression EXP Ellagic Acid results in increased expression of IQGAP2 mRNA CTD PMID:12002526 NCBI chr 5:76,403,285...76,708,132
Ensembl chr 5:76,403,285...76,708,132
JBrowse link
G IRF9 interferon regulatory factor 9 increases expression EXP Ellagic Acid results in increased expression of IRF9 mRNA CTD PMID:12002526 NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,234...24,168,043
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Ellagic Acid results in decreased expression of JUN mRNA; Ellagic Acid results in decreased expression of JUN protein modified form CTD PMID:23811531 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KLK3 kallikrein related peptidase 3 decreases expression EXP Ellagic Acid results in decreased expression of KLK3 mRNA CTD PMID:12002526 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G LITAF lipopolysaccharide induced TNF factor increases expression EXP Ellagic Acid results in increased expression of LITAF mRNA CTD PMID:12002526 NCBI chr16:11,547,722...11,640,317
Ensembl chr16:11,547,722...11,636,381
JBrowse link
G MAP1A microtubule associated protein 1A decreases expression EXP Ellagic Acid results in decreased expression of MAP1A mRNA CTD PMID:12002526 NCBI chr15:43,510,954...43,531,611
Ensembl chr15:43,510,958...43,531,620
JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 decreases expression EXP Ellagic Acid results in decreased expression of MAP3K1 mRNA; Ellagic Acid results in decreased expression of MAP3K1 protein CTD PMID:23811531 NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:32971123 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK11 mitogen-activated protein kinase 11 increases expression EXP Ellagic Acid results in increased expression of MAPK11 mRNA CTD PMID:23811531 NCBI chr22:50,263,713...50,270,380
Ensembl chr22:50,263,713...50,270,767
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO Ellagic Acid inhibits the reaction [phosalone results in increased expression of MAPK14 protein] CTD PMID:27965107 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:32971123 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK8 protein CTD PMID:15735102 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP [Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK9 protein CTD PMID:15735102 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Ellagic Acid results in decreased activity of MGST1 protein CTD PMID:16125204 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MIR140 microRNA 140 multiple interactions ISO ellagic acid inhibits the reaction [hypoxia and acute myocardial infarction decreases expression of mir140 RNA in cardiac muscle cells] RGD PMID:28922712 RGD:329347824 NCBI chr16:69,933,081...69,933,180
Ensembl chr16:69,933,081...69,933,180
JBrowse link
G MMD monocyte to macrophage differentiation associated increases expression EXP Ellagic Acid results in increased expression of MMD mRNA CTD PMID:12002526 NCBI chr17:55,392,622...55,421,835
Ensembl chr17:55,392,622...55,421,924
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression
decreases activity
EXP Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein; zinc chloride inhibits the reaction [Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein]
Ellagic Acid results in decreased expression of MMP2 mRNA
Ellagic Acid results in decreased activity of MMP2 protein
CTD PMID:21573219 PMID:35179410 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
decreases activity
EXP Ellagic Acid results in decreased expression of MMP9 mRNA
Ellagic Acid results in decreased activity of MMP9 protein
CTD PMID:35179410 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:32971123 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
increases expression
affects response to substance
EXP
ISO
Ellagic Acid affects the localization of NFE2L2 protein
Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]
[Ellagic Acid co-treated with Diquat] results in increased expression of NFE2L2 mRNA; Ellagic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of NFE2L2 mRNA]
Ellagic Acid results in increased expression of NFE2L2 mRNA
[Paraquat co-treated with Ellagic Acid] results in increased expression of and affects the localization of NFE2L2 protein; [Paraquat co-treated with Ellagic Acid] results in increased expression of NFE2L2 mRNA; Ellagic Acid results in increased expression of and affects the localization of NFE2L2 protein
Ellagic Acid results in increased expression of NFE2L2 mRNA; Ellagic Acid results in increased expression of NFE2L2 protein
NFE2L2 protein affects the susceptibility to Ellagic Acid
CTD PMID:22386815 PMID:23546295 PMID:30503583 PMID:35236242 PMID:35268077 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 decreases expression EXP Ellagic Acid results in decreased expression of NFKB2 mRNA CTD PMID:12002526 PMID:35179410 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524
JBrowse link
G NNAT neuronatin increases expression EXP Ellagic Acid results in increased expression of NNAT mRNA CTD PMID:12002526 NCBI chr20:37,521,250...37,523,690
Ensembl chr20:37,521,206...37,523,690
JBrowse link
G NOP56 NOP56 ribonucleoprotein decreases expression EXP Ellagic Acid results in decreased expression of NOP56 mRNA CTD PMID:12002526 NCBI chr20:2,652,632...2,658,393
Ensembl chr20:2,652,593...2,658,393
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
Ellagic Acid results in decreased expression of NOS2 mRNA
CTD PMID:28815802 PMID:35179410 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPAS2 neuronal PAS domain protein 2 increases expression EXP Ellagic Acid results in increased expression of NPAS2 mRNA CTD PMID:12002526 NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP
ISO
Ellagic Acid results in increased expression of NQO1 mRNA; Ellagic Acid results in increased expression of NQO1 protein
Ellagic Acid inhibits the reaction [Diquat results in decreased expression of NQO1 mRNA]
[Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 protein
CTD PMID:23546295 PMID:35268077 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP
ISO
Ellagic Acid results in increased activity of NR1I3 protein CTD PMID:21821919 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G PARG poly(ADP-ribose) glycohydrolase decreases activity EXP Ellagic Acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr10:49,818,279...49,942,027
Ensembl chr10:49,818,279...49,970,203
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO Ellagic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:25247703 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO [resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNA] CTD PMID:20103723 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 multiple interactions ISO Ellagic Acid inhibits the reaction [Rotenone results in increased nitrosation of and results in decreased activity of PDIA2 protein] CTD PMID:25247703 NCBI chr16:283,164...287,215
Ensembl chr16:283,164...287,215
JBrowse link
G PGD phosphogluconate dehydrogenase decreases activity EXP Ellagic Acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PLA2G2A phospholipase A2 group IIA decreases expression EXP Ellagic Acid results in decreased expression of PLA2G2A mRNA CTD PMID:20816778 NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416
JBrowse link
G PLP2 proteolipid protein 2 increases expression EXP Ellagic Acid results in increased expression of PLP2 mRNA CTD PMID:12002526 NCBI chr  X:49,171,898...49,175,235
Ensembl chr  X:49,171,898...49,175,235
JBrowse link
G PML PML nuclear body scaffold decreases expression EXP Ellagic Acid results in decreased expression of PML mRNA CTD PMID:12002526 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827
JBrowse link
G PPARD peroxisome proliferator activated receptor delta decreases expression EXP Ellagic Acid results in decreased expression of PPARD mRNA CTD PMID:12002526 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression EXP Ellagic Acid results in increased expression of PPARG protein CTD PMID:23811531 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression
multiple interactions
ISO Ellagic Acid results in decreased expression of PPARGC1A mRNA
Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of PPARGC1A mRNA]
CTD PMID:30503583 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 decreases expression EXP Ellagic Acid results in decreased expression of PRKG1 mRNA CTD PMID:12002526 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G PTN pleiotrophin decreases expression
increases expression
EXP Ellagic Acid results in decreased expression of PTN mRNA
Ellagic Acid results in increased expression of PTN mRNA
CTD PMID:12002526 NCBI chr 7:137,227,341...137,343,733
Ensembl chr 7:137,227,341...137,343,774
JBrowse link
G PTPRN2 protein tyrosine phosphatase receptor type N2 increases expression EXP Ellagic Acid results in increased expression of PTPRN2 mRNA CTD PMID:12002526 NCBI chr 7:157,539,056...158,587,823
Ensembl chr 7:157,539,056...158,587,823
JBrowse link
G RAN RAN, member RAS oncogene family decreases expression EXP Ellagic Acid results in decreased expression of RAN mRNA CTD PMID:12002526 NCBI chr12:130,872,066...130,877,678
Ensembl chr12:130,872,037...130,877,678
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions ISO Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 protein] CTD PMID:27965107 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RECK reversion inducing cysteine rich protein with kazal motifs increases expression
multiple interactions
EXP Ellagic Acid results in increased expression of RECK mRNA; Ellagic Acid results in increased expression of RECK protein
zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]; zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein]
CTD PMID:21573219 NCBI chr 9:36,036,913...36,124,455
Ensembl chr 9:36,036,913...36,124,455
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
EXP
ISO
Ellagic Acid results in decreased expression of RELA mRNA
Ellagic Acid inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]
Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RELA protein]
CTD PMID:12002526 PMID:24877639 PMID:27473819 PMID:27965107 PMID:32971123 More... NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RGS5 regulator of G protein signaling 5 decreases expression EXP Ellagic Acid results in decreased expression of RGS5 mRNA CTD PMID:12002526 NCBI chr 1:163,142,299...163,321,735
Ensembl chr 1:163,111,121...163,321,791
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP Ellagic Acid results in decreased expression of SCD mRNA CTD PMID:20816778 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SEPTIN2 septin 2 increases expression EXP Ellagic Acid results in increased expression of SEPTIN2 mRNA CTD PMID:12002526 NCBI chr 2:241,315,355...241,354,027
Ensembl chr 2:241,315,100...241,354,027
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Ellagic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of SOD1 mRNA]; Ellagic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of SOD1 protein] CTD PMID:34944019 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA] CTD PMID:29935397 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 decreases expression EXP Ellagic Acid results in decreased expression of SOD3 mRNA CTD PMID:12002526 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein] CTD PMID:32971123 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions
increases expression
ISO Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of STAR mRNA]
Ellagic Acid results in increased expression of STAR mRNA
CTD PMID:30503583 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STAT3 signal transducer and activator of transcription 3 increases expression
decreases expression
EXP Ellagic Acid results in increased expression of STAT3 mRNA
Ellagic Acid results in decreased expression of STAT3 mRNA
CTD PMID:12002526 PMID:20816778 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TAF1C TATA-box binding protein associated factor, RNA polymerase I subunit C decreases expression EXP Ellagic Acid results in decreased expression of TAF1C mRNA CTD PMID:12002526 NCBI chr16:84,177,855...84,187,057
Ensembl chr16:84,177,847...84,187,070
JBrowse link
G TCF12 transcription factor 12 increases expression EXP Ellagic Acid results in increased expression of TCF12 mRNA CTD PMID:12002526 NCBI chr15:56,918,090...57,291,310
Ensembl chr15:56,918,623...57,299,281
JBrowse link
G TERT telomerase reverse transcriptase multiple interactions
increases expression
EXP
ISO
Ellagic Acid inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]
Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]
Ellagic Acid results in increased expression of TERT mRNA alternative form
CTD PMID:19501078 PMID:27965107 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TFAM transcription factor A, mitochondrial decreases expression EXP Ellagic Acid results in decreased expression of TFAM mRNA CTD PMID:12002526 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
EXP
ISO
Ellagic Acid results in increased expression of TGFB1 mRNA
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]
CTD PMID:12002526 PMID:24877639 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
Ellagic Acid inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; Ellagic Acid inhibits the reaction [TNF protein results in increased activity of and affects the secretion of CXCL8 protein]
Ellagic Acid results in decreased expression of TNF mRNA
CTD PMID:21762681 PMID:24877639 PMID:27473819 PMID:27965107 PMID:28815802 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a multiple interactions
affects binding
ISO Ellagic Acid inhibits the reaction [TNFSF11 protein binds to TNFRSF11A protein]
Ellagic Acid binds to TNFRSF11A protein
CTD PMID:32971123 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288
JBrowse link
G TNFSF11 TNF superfamily member 11 affects binding
multiple interactions
ISO Ellagic Acid binds to TNFSF11 protein
Ellagic Acid inhibits the reaction [TNFSF11 protein binds to TNFRSF11A protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
CTD PMID:32971123 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G TNNT2 troponin T2, cardiac type multiple interactions ISO Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:21762681 NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP
ISO
Ellagic Acid results in increased expression of TP53 mRNA; Ellagic Acid results in increased expression of TP53 protein
Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 protein]
Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]
CTD PMID:15735102 PMID:23554011 PMID:27965107 PMID:35179410 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP Ellagic Acid results in decreased expression of UGP2 mRNA CTD PMID:12002526 NCBI chr 2:63,840,969...63,891,560
Ensembl chr 2:63,840,952...63,891,562
JBrowse link
G USP4 ubiquitin specific peptidase 4 decreases expression EXP Ellagic Acid results in decreased expression of USP4 mRNA CTD PMID:12002526 NCBI chr 3:49,277,144...49,340,053
Ensembl chr 3:49,277,144...49,340,712
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein] CTD PMID:35236242 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WARS1 tryptophanyl-tRNA synthetase 1 increases expression EXP Ellagic Acid results in increased expression of WARS1 mRNA CTD PMID:12002526 NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805
JBrowse link
G WEE1 WEE1 G2 checkpoint kinase decreases expression EXP Ellagic Acid results in decreased expression of WEE1 protein CTD PMID:23554011 NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457
JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 decreases expression EXP Ellagic Acid results in decreased expression of ZBTB16 mRNA CTD PMID:12002526 NCBI chr11:114,059,711...114,256,770
Ensembl chr11:114,059,041...114,256,765
JBrowse link
G ZMYM2 zinc finger MYM-type containing 2 increases expression EXP Ellagic Acid results in increased expression of ZMYM2 mRNA CTD PMID:12002526 NCBI chr13:19,863,840...20,089,115
Ensembl chr13:19,958,677...20,091,829
JBrowse link
fusidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin] CTD PMID:26888941 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO
EXP
Fusidic Acid results in decreased activity of ABCB11 protein
Fusidic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:12106615 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27676153 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions ISO Fusidic Acid results in decreased expression of and results in decreased activity of ABCC2 protein CTD PMID:12106615 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:26888941 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G SLC10A1 solute carrier family 10 member 1 multiple interactions EXP Fusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid] CTD PMID:27676153 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions ISO Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:26888941 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 decreases activity
multiple interactions
EXP Fusidic Acid results in decreased activity of SLCO1B1 protein
Fusidic Acid inhibits the reaction [SLCO1B1 protein results in increased uptake of Rosuvastatin Calcium]
CTD PMID:26888941 PMID:27676153 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions
decreases activity
EXP
ISO
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid results in decreased activity of SLCO1B3 protein
CTD PMID:26888941 PMID:27676153 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:27676153 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
gamendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 affects binding ISO Gamendazole binds to Eef1a1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 6:73,515,750...73,521,032
Ensembl chr 6:73,489,308...73,525,587
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 affects binding ISO gamendazole binds to Hsp90ab1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 decreases activity EXP Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 decreases activity EXP Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases metabolic processing
decreases metabolic processing
EXP CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide
CTD PMID:10208645 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression
decreases activity
EXP
ISO
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Glyburide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of ABCB11 mRNA
Glyburide results in increased expression of ABCB11 mRNA
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium
CTD PMID:11343252 PMID:15465654 PMID:15618715 PMID:19853032 PMID:20147439 More... NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 increases expression ISO Glyburide results in increased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases activity EXP Glyburide results in decreased activity of ABCC1 protein CTD PMID:15652236 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO Glyburide results in increased expression of ABCC2 mRNA CTD PMID:27765674 PMID:35708773 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO Glyburide results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) increases expression ISO Glyburide results in increased expression of ABCC4 mRNA CTD PMID:35708773 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 increases response to substance
affects binding
multiple interactions
ISO ABCC8 protein results in increased susceptibility to Glyburide
Glyburide binds to ABCC8 protein; Glyburide binds to ABCC8 protein mutant form
Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]; resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]
CTD PMID:17138562 PMID:19095654 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 affects binding
decreases activity
multiple interactions
ISO Glyburide binds to ABCC9 protein mutant form
Glyburide results in decreased activity of ABCC9 protein
[Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein; Estradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]; resveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]
CTD PMID:17138562 PMID:19095654 PMID:22622455 PMID:28842488 NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) decreases export
multiple interactions
increases export
EXP ABCG2 protein polymorphism results in decreased export of Glyburide
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]; Genistein inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]
CTD PMID:26850786 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 increases expression ISO Glyburide results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Glyburide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]] CTD PMID:35305975 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP Glyburide inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:10799337 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]
CTD PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 decreases activity EXP Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 decreases activity EXP Glyburide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP Glyburide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein] CTD PMID:21800153 PMID:33724628 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin affects binding EXP Glyburide binds to ALB protein CTD PMID:20974553 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions EXP Glyburide promotes the reaction [1,2-linoleoylphosphatidylcholine results in increased secretion of APOA1 protein]; Glyburide promotes the reaction [Clofibrate results in increased secretion of APOA1 protein] CTD PMID:19717637 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G ARG1 arginase 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]
CTD PMID:32522579 PMID:32860822 PMID:34052309 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:33724628 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:21800153 PMID:33724628 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CAPN2 calpain 2 increases expression EXP Glyburide results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP1 caspase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Ozone results in increased cleavage of CASP1 protein]
CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Glyburide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]]
Glyburide results in increased expression of CASP3 mRNA
Glyburide results in increased activity of CASP3 protein
CTD PMID:16310184 PMID:33652124 PMID:35305975 PMID:36504472 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]]
CTD PMID:23716880 PMID:24760747 PMID:26700463 PMID:26748309 PMID:28757134 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions
decreases activity
EXP
ISO
Glyburide binds to and results in decreased activity of CFTR protein; Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]
Glyburide results in decreased activity of CFTR protein
Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]
Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]; Glyburide inhibits the reaction [CFTR protein affects the transport of Chlorides]
CTD PMID:14502435 PMID:14967738 PMID:15131065 PMID:15236628 PMID:15371258 More... NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression ISO Glyburide results in decreased expression of COL1A1 mRNA CTD PMID:35708773 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CP ceruloplasmin multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein] CTD PMID:26748309 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CST3 cystatin C multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA; Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]; pyrvinium inhibits the reaction [[Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]] CTD PMID:35305975 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein] CTD PMID:32375810 PMID:34052309 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10799337 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]] CTD PMID:27890915 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]] CTD PMID:35305975 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions ISO Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:25641191 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PC3 glucose-6-phosphatase catalytic subunit 3 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] CTD PMID:31345080 NCBI chr17:44,070,673...44,076,344
Ensembl chr17:44,070,620...44,082,151
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 PMID:31345080 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSDMD gasdermin D multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of GSR protein] CTD PMID:26748309 PMID:33724628 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:30817903 PMID:36999408 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G IFNG interferon gamma multiple interactions ISO Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL12B interleukin 12B multiple interactions ISO Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863
JBrowse link
G IL17A interleukin 17A multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]] CTD PMID:35305975 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]
Glyburide inhibits the reaction [Ozone results in increased expression of IL18 protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]
CTD PMID:25338942 PMID:32167222 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1B interleukin 1 beta affects secretion
multiple interactions
ISO Glyburide affects the secretion of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Ozone results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
CTD PMID:15578659 PMID:25338942 PMID:30817903 PMID:32167222 PMID:32375810 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
CTD PMID:24760747 PMID:24849676 PMID:26748309 PMID:30817903 PMID:33724628 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions
increases response to substance
increases secretion
increases expression
decreases expression
EXP
ISO
[Glyburide co-treated with Glucose] results in increased expression of INS protein; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]
Glyburide results in increased susceptibility to INS protein
Glyburide results in increased expression of INS mRNA
Glyburide results in decreased expression of INS protein
CTD PMID:3116364 PMID:10430617 PMID:11305519 PMID:15642492 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions
increases secretion
ISO Glyburide inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Glyburide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
Glyburide results in increased secretion of INS1 protein
Glyburide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]
CTD PMID:26700463 PMID:26748309 PMID:29658312 PMID:30445784 PMID:30582900 More... NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions EXP IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:33724628 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein] CTD PMID:32522579 PMID:32860822 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Glyburide results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions
decreases response to substance
ISO Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]
KCNJ11 protein mutant form results in decreased susceptibility to Glyburide
CTD PMID:15949470 PMID:28842488 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331
JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 decreases activity
decreases response to substance
EXP
ISO
Glyburide results in decreased activity of KCNJ8 protein
KCNJ8 protein mutant form results in decreased susceptibility to Glyburide
CTD PMID:20050851 PMID:28842488 NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600
JBrowse link
G KCNK18 potassium two pore domain channel subfamily K member 18 multiple interactions EXP Glyburide inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr10:117,197,489...117,210,299
Ensembl chr10:117,197,489...117,210,299
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LYZ lysozyme increases secretion
decreases secretion
EXP Glyburide results in increased secretion of LYZ protein
Glyburide results in decreased secretion of LYZ protein
CTD PMID:15194485 PMID:15234967 NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases expression
ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK1 protein modified form] CTD PMID:20860660 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases expression
ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK3 protein modified form] CTD PMID:20860660 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MBP myelin basic protein multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
JBrowse link
G MIR146A microRNA 146a multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased activity of MPO protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of MPO protein] CTD PMID:25338942 PMID:35305975 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NCF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:32375810 PMID:34052309 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NEFL neurofilament light chain multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein] CTD PMID:32522579 PMID:32860822 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO Glyburide inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]] CTD PMID:27246103 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 PMID:36999408 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Ozone results in increased expression of NLRP3 protein]
CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; KN 93 inhibits the reaction [Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]
CTD PMID:16257489 PMID:27246103 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]] CTD PMID:27890915 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 decreases expression ISO Glyburide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PKLR pyruvate kinase L/R multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] CTD PMID:29223569 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:30817903 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:25338942 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:33724628 PMID:36504472 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression
multiple interactions
ISO Glyburide results in decreased expression of SLC10A1 mRNA
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of SLC10A1 mRNA
CTD PMID:27765674 PMID:28391356 PMID:35708773 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein] CTD PMID:33724628 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:29223569 PMID:33724628 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions ISO Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:16725203 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP Glyburide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 multiple interactions EXP Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
G SNCA synuclein alpha multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein] CTD PMID:32375810 PMID:34052309 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]] CTD PMID:35305975 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:16725203 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP Glyburide results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]]
CTD PMID:16257489 PMID:24760747 PMID:26748309 PMID:30817903 PMID:32375810 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]] CTD PMID:35305975 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 protein]
Glyburide results in increased expression of TP53 mRNA
CTD PMID:30817903 PMID:33387473 PMID:33652124 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 decreases activity ISO Glyburide results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr19:49,157,792...49,211,836
Ensembl chr19:49,157,741...49,211,836
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO [Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein CTD PMID:22622455 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
IC-87114 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]
IC 87114 results in decreased phosphorylation of AKT1 protein
CTD PMID:16179367 PMID:19176369 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions ISO IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein] CTD PMID:22315502 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G FOXO3 forkhead box O3 multiple interactions
decreases phosphorylation
ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]
IC 87114 results in decreased phosphorylation of FOXO3 protein
CTD PMID:16179367 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha decreases phosphorylation ISO IC 87114 results in decreased phosphorylation of GSK3A protein CTD PMID:16179367 NCBI chr19:42,230,190...42,242,602
Ensembl chr19:42,226,225...42,242,625
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases phosphorylation ISO IC 87114 results in decreased phosphorylation of GSK3B protein CTD PMID:16179367 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G IL10 interleukin 10 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein] CTD PMID:33711354 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL18 interleukin 18 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein] CTD PMID:33711354 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL4 interleukin 4 multiple interactions ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:16179367 PMID:33711354 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein] CTD PMID:33711354 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein] CTD PMID:33711354 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]
IC 87114 results in decreased phosphorylation of MAPK1 protein
CTD PMID:16179367 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]
IC 87114 results in decreased phosphorylation of MAPK3 protein
CTD PMID:16179367 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta decreases activity
multiple interactions
ISO IC 87114 results in decreased activity of PIK3CD protein
IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein]
CTD PMID:16179367 PMID:33711354 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein] CTD PMID:33711354 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 multiple interactions
increases response to substance
ISO IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]
PTPN11 protein mutant form results in increased susceptibility to IC 87114
CTD PMID:22315502 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO IC 87114 results in decreased phosphorylation of RPS6KB1 protein CTD PMID:16179367 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
idelalisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; AKT activator SC79 inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:31445927 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein] CTD PMID:31445927 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein] CTD PMID:31445927 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein] CTD PMID:31445927 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein] CTD PMID:31445927 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein CTD PMID:23676220 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; AKT activator SC79 inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein] CTD PMID:31445927 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions EXP [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein] CTD PMID:31445927 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression ISO idelalisib decreases expression of Cxcl1 protein in liver and spleen RGD PMID:27999013 RGD:40890273 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
affects response to substance
ISO
EXP
FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]
idelalisib affects the susceptibility to FAS protein
CTD PMID:31445927 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FASLG Fas ligand multiple interactions EXP [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein; [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein; [idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]; AKT activator SC79 inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; AKT activator SC79 inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; AKT activator SC79 inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein] CTD PMID:31445927 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G GPT glutamic--pyruvic transaminase increases expression
affects expression
multiple interactions
ISO idelalisib results in increased expression of ALT protein
idelalisib affects the expression of GPT protein
[Galactosamine co-treated with Lipopolysaccharides] promotes the reaction [idelalisib results in increased expression of ALT protein]; FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]
CTD PMID:31445927 PMID:31501888 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP
ISO
idelalisib results in increased expression of HIF1A protein
idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein]
CTD PMID:34978009 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G IFNG interferon gamma decreases expression ISO idelalisib decreases expression of Ifng protein in liver, spleen and lymph node RGD PMID:27999013 RGD:40890273 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 decreases expression ISO idelalisib decreases expression of Il10 protein in liver, lymph node and spleen RGD PMID:27999013 RGD:40890273 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL4 interleukin 4 decreases expression ISO idelalisib decreases expression of Il4 protein in lymph node RGD PMID:27999013 RGD:40890273 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 decreases expression ISO idelalisib decreases expression of Il6 protein in liver and spleen RGD PMID:27999013 RGD:40890273 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MIR122 microRNA 122 affects expression ISO idelalisib affects the expression of MIR122 mRNA CTD PMID:31501888 NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
multiple interactions
EXP
ISO
idelalisib results in decreased expression of MMP9 protein
idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
CTD PMID:34978009 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP
ISO
idelalisib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]
idelalisib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]; idelalisib promotes the reaction [Lipopolysaccharides results in increased expression of MTOR mRNA]
CTD PMID:34978009 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G NAT10 N-acetyltransferase 10 increases expression EXP idelalisib results in increased expression of NAT10 mRNA CTD PMID:35877022 NCBI chr11:34,105,629...34,146,908
Ensembl chr11:34,105,617...34,147,670
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein CTD PMID:23676220 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions
increases expression
ISO idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]
idelalisib results in increased expression of PIK3CA mRNA
CTD PMID:31522336 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta multiple interactions
increases expression
ISO idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]
idelalisib results in increased expression of PIK3CB mRNA
CTD PMID:31522336 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta multiple interactions
increases expression
ISO idelalisib inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]
idelalisib results in increased expression of PIK3CD mRNA
CTD PMID:31522336 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma decreases expression ISO idelalisib results in decreased expression of PIK3CG mRNA CTD PMID:31522336 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 increases expression EXP idelalisib results in increased expression of PIK3IP1 mRNA CTD PMID:23676220 NCBI chr22:31,281,593...31,292,534
Ensembl chr22:31,281,594...31,292,534
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP AKT activator SC79 inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein] CTD PMID:31445927 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO idelalisib inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]; idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]; idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA] CTD PMID:31522336 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases response to substance
EXP [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]
idelalisib results in increased susceptibility to TNF protein
CTD PMID:31445927 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP
ISO
idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]
idelalisib promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]
CTD PMID:34978009 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
lonidamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of AKT1 protein]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] CTD PMID:20605902 PMID:21889928 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AQP9 aquaporin 9 multiple interactions ISO lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911
JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects localization
multiple interactions
EXP lonidamine affects the localization of BAX protein
Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]
CTD PMID:20605902 PMID:21889928 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]] CTD PMID:21889928 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP lonidamine results in decreased expression of BCL2L1 protein CTD PMID:21889928 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist increases activity
multiple interactions
EXP lonidamine results in increased activity of BID protein
[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of BID protein
CTD PMID:20605902 PMID:21889928 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP1 caspase 1 multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of CASP1 protein]; lonidamine inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [Poly dA-dT results in increased cleavage of CASP1 protein] CTD PMID:36577999 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein CTD PMID:20605902 PMID:21889928 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein; BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:21889928 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 multiple interactions EXP [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]; lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; lonidamine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:20605902 PMID:21889928 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CFTR CF transmembrane conductance regulator decreases activity
multiple interactions
EXP
ISO
lonidamine results in decreased activity of CFTR protein
lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]
CTD PMID:12606488 PMID:15634668 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G GSDMD gasdermin D multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of GSDMD protein] CTD PMID:36577999 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062
JBrowse link
G HTRA2 HtrA serine peptidase 2 multiple interactions EXP [lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein CTD PMID:21889928 NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,596...74,533,350
JBrowse link
G IL18 interleukin 18 multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of IL18 protein] CTD PMID:36577999 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and affects the cleavage of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of IL1B protein]; lonidamine inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [Poly dA-dT results in increased secretion of IL1B protein] CTD PMID:36577999 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK1 protein] CTD PMID:21889928 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK3 protein] CTD PMID:21889928 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP lonidamine results in decreased expression of MCL1 protein CTD PMID:21889928 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G PYCARD PYD and CARD domain containing affects binding
multiple interactions
ISO lonidamine binds to PYCARD protein
lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to PYCARD protein]]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] inhibits the reaction [PYCARD protein binds to PYCARD protein]]
CTD PMID:36577999 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions
increases phosphorylation
EXP arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6 protein] CTD PMID:21889928 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
EXP arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21889928 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G STK11 serine/threonine kinase 11 increases phosphorylation EXP lonidamine results in increased phosphorylation of STK11 protein CTD PMID:23041229 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions
decreases expression
EXP arsenic trioxide promotes the reaction [lonidamine results in decreased expression of XIAP protein]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein] CTD PMID:20605902 PMID:21889928 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972
JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 protein CTD PMID:23466342 PMID:27888070 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases expression ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC1 protein CTD PMID:27888070 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of ABCC2 mRNA] CTD PMID:15896333 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 decreases expression EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC5 protein CTD PMID:23994249 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein] CTD PMID:21712253 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA] CTD PMID:16849647 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of ACTA2 protein] CTD PMID:33895847 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ACVR2B activin A receptor type 2B multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA] CTD PMID:12710931 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein] CTD PMID:19356108 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADRA1A adrenoceptor alpha 1A multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose] CTD PMID:15550506 NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein] CTD PMID:21807062 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AGT angiotensinogen multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:15121739 PMID:16325820 PMID:23300732 PMID:25398788 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AHR aryl hydrocarbon receptor increases expression
multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AHR mRNA
CTD PMID:22406437 PMID:27020609 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 decreases expression EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein] CTD PMID:21787718 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases expression
decreases reaction
decreases phosphorylation
multiple interactions
decreases expression
decreases activity
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AKT1 protein
LY294002 inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Glucose co-treated with Calcitriol] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of and results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hemistepsin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [quinocetone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzop