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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
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Accession:CHEBI:76881 term browser browse the term
Definition:An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*).
Synonyms:related_synonym: EC 2.7.1.* inhibitor;   EC 2.7.1.* inhibitors;   phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors



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glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
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LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
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G PRKCZ protein kinase C zeta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
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tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP tolfenamic acid results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 494
    role 494
      biological role 501
        biochemical role 460
          enzyme inhibitor 373
            EC 2.* (transferase) inhibitor 181
              EC 2.7.* (P-containing group transferase) inhibitor 179
                EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor 4
                  EC 2.7.1.1 (hexokinase) inhibitor + 0
                  EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor + 0
                  EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor + 0
                  EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor + 2
                  EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor + 0
                  EC 2.7.1.153 (phosphatidylinositol-4,5-bisphosphate 3-kinase) inhibitor + 0
                  EC 2.7.1.33 (pantothenate kinase) inhibitor + 2
                  EC 2.7.1.40 (pyruvate kinase) inhibitor + 0
                  EC 2.7.1.91 (sphingosine kinase) inhibitor + 0
                  inositol phosphorylceramide synthase inhibitor + 0
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