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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
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Accession:CHEBI:76881 term browser browse the term
Definition:An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*).
Synonyms:related_synonym: EC 2.7.1.* inhibitor;   EC 2.7.1.* inhibitors;   phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors


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1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression ISO 1,10-phenanthroline results in decreased expression of ACE mRNA CTD PMID:19502547 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases activity
multiple interactions		 EXP
ISO		 1,10-phenanthroline results in decreased activity of AHR protein
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Zinc inhibits the reaction [1,10-phenanthroline results in decreased activity of AHR protein]		 CTD PMID:1322109 PMID:2160969 PMID:27180721 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO 1,10-phenanthroline results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:15,912,431...15,923,045 JBrowse link
G Akap9 A-kinase anchoring protein 9 increases expression ISO 1,10-phenanthroline results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C4 protein CTD PMID:12604236 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C3 protein CTD PMID:12604236 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO 1,10-phenanthroline results in increased expression of ALDOA mRNA CTD PMID:19502547 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression ISO 1,10-phenanthroline results in increased expression of ALDOC mRNA CTD PMID:19502547 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 1,10-phenanthroline results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:46,269,025...46,271,971
Ensembl chr16:46,268,443...46,271,963 		JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases activity
multiple interactions		 ISO 1,10-phenanthroline results in decreased activity of ANPEP protein
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]		 CTD PMID:17109655 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression ISO 1,10-phenanthroline results in decreased expression of AQP3 mRNA CTD PMID:19641517 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Aspa aspartoacylase decreases activity ISO 1,10-phenanthroline results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein CTD PMID:21355074 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO 1,10-phenanthroline results in decreased expression of BNIP3L mRNA CTD PMID:19502547 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Ca9 carbonic anhydrase 9 increases expression ISO 1,10-phenanthroline results in increased expression of CA9 mRNA CTD PMID:19502547 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Cat catalase decreases expression ISO 1,10-phenanthroline results in decreased expression of CAT mRNA CTD PMID:19502547 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd83 CD83 molecule increases expression ISO 1,10-phenanthroline results in increased expression of CD83 mRNA CTD PMID:19641517 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions		 ISO 1,10-phenanthroline results in increased expression of CD86 mRNA
Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]		 CTD PMID:19641517 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO 1,10-phenanthroline results in increased activity of CFTR protein CTD PMID:15921678 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases stability		 ISO
EXP		 1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
1,10-phenanthroline results in increased stability of CYP1A1 mRNA		 CTD PMID:1322109 PMID:19896525 PMID:27180721 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression ISO 1,10-phenanthroline results in increased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO 1,10-phenanthroline results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Egr1 early growth response 1 increases expression ISO 1,10-phenanthroline results in increased expression of EGR1 mRNA CTD PMID:19502547 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eno1 enolase 1 increases expression ISO 1,10-phenanthroline results in increased expression of ENO1 mRNA CTD PMID:19502547 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Eno2 enolase 2 increases expression ISO 1,10-phenanthroline results in increased expression of ENO2 mRNA CTD PMID:19502547 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO 1,10-phenanthroline results in decreased expression of ERCC2 mRNA CTD PMID:19502547 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO 1,10-phenanthroline results in increased expression of GAPDH mRNA CTD PMID:19502547 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO 1,10-phenanthroline results in decreased expression of GPX3 mRNA CTD PMID:19502547 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AX protein modified form CTD PMID:22659117 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO 1,10-phenanthroline results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 1,10-phenanthroline results in increased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO 4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]
1,10-phenanthroline results in increased activity of HIF1A protein		 CTD PMID:19091749 PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO 1,10-phenanthroline results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO 1,10-phenanthroline results in increased expression of HILPDA mRNA CTD PMID:19502547 NCBI chr 4:57,871,076...57,875,206 JBrowse link
G Hk1 hexokinase 1 increases expression ISO 1,10-phenanthroline results in increased expression of HK1 mRNA CTD PMID:19502547 NCBI chr20:30,230,488...30,332,161
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO 1,10-phenanthroline results in increased expression of HK2 mRNA CTD PMID:19502547 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein]; 1,10-phenanthroline inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA] CTD PMID:9747510 PMID:15629867 PMID:20888885 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 1,10-phenanthroline affects the reaction [Smoke results in increased expression of ICAM1 protein] CTD PMID:15560890 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP 1,10-phenanthroline results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO 1,10-phenanthroline results in decreased expression of IL1R1 mRNA CTD PMID:19502547 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Mustard Gas results in increased degradation of LAMC2 protein] CTD PMID:18095945 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO 1,10-phenanthroline results in increased expression of LDHA mRNA CTD PMID:19502547 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 multiple interactions ISO [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein CTD PMID:21355074 NCBI chr  X:37,410,914...37,461,130
Ensembl chr  X:37,410,811...37,464,430 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 1,10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO 1,10-phenanthroline results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO 1,10-phenanthroline results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]		 CTD PMID:20177776 PMID:20195827 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO 1,10-phenanthroline results in increased expression of NPPB mRNA CTD PMID:19502547 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nub1 negative regulator of ubiquitin-like proteins 1 increases expression ISO 1,10-phenanthroline results in increased expression of NUB1 mRNA CTD PMID:19502547 NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694 		JBrowse link
G Ocln occludin multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein] CTD PMID:19013514 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 increases expression ISO 1,10-phenanthroline results in increased expression of P4HA2 mRNA CTD PMID:19502547 NCBI chr10:38,243,047...38,271,989
Ensembl chr10:38,243,139...38,287,314 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO 1,10-phenanthroline results in increased expression of PDK1 mRNA CTD PMID:19502547 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO 1,10-phenanthroline results in increased expression of PDK3 mRNA CTD PMID:19502547 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO 1,10-phenanthroline results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO 1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein] CTD PMID:20177776 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO 1,10-phenanthroline results in increased expression of PLOD3 mRNA CTD PMID:19502547 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta decreases expression ISO 1,10-phenanthroline results in decreased expression of PPP2R1B mRNA CTD PMID:19502547 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Psph phosphoserine phosphatase decreases expression ISO 1,10-phenanthroline results in decreased expression of PSPH mRNA CTD PMID:19502547 NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO 1,10-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:8573067 PMID:12604236 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Sele selectin E multiple interactions ISO 1,10-phenanthroline affects the reaction [Smoke results in increased expression of SELE protein] CTD PMID:15560890 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO 1,10-phenanthroline results in increased expression of SERPINE1 mRNA CTD PMID:19502547 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein]; 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein] CTD PMID:15629867 PMID:20674559 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein] CTD PMID:20674559 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein CTD PMID:21355074 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide affects the localization of STAT3 protein] CTD PMID:10364193 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tfrc transferrin receptor increases expression ISO 1,10-phenanthroline results in increased expression of TFRC mRNA CTD PMID:19502547 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timm17a translocase of inner mitochondrial membrane 17A multiple interactions ISO 1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein] CTD PMID:24315374 NCBI chr13:46,731,117...46,742,604
Ensembl chr13:46,730,660...46,742,655 		JBrowse link
G Tp53 tumor protein p53 affects folding ISO 1,10-phenanthroline affects the folding of TRP53 protein CTD PMID:8467489 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 ISO 1,10-phenanthroline results in increased expression of VEGFA mRNA; 1,10-phenanthroline results in increased expression of VEGFA protein
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]		 CTD PMID:19502547 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
bathocuproine disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA] CTD PMID:15477007 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ARHGDIA mRNA CTD PMID:15477007 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA] CTD PMID:15477007 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] CTD PMID:20194531 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 PMID:21242307 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO bathocuproine sulfonate results in decreased expression of BCL2 protein CTD PMID:24614111 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]] CTD PMID:15477007 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of CASP3 protein] CTD PMID:10941151 PMID:11239917 PMID:18056745 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]] CTD PMID:15477007 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:11006087 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL3 mRNA] CTD PMID:15477007 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]] CTD PMID:15477007 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930 		JBrowse link
G Cd200 Cd200 molecule multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA] CTD PMID:15477007 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA] CTD PMID:15477007 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh17 cadherin 17 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDH17 mRNA]; [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CDH17 mRNA CTD PMID:15477007 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Clu clusterin multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cntnap1 contactin associated protein 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CNTNAP1 mRNA CTD PMID:15477007 NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA] CTD PMID:15477007 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein] CTD PMID:17032174 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpsf1 cleavage and polyadenylation specific factor 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CPSF1 mRNA CTD PMID:15477007 NCBI chr 7:108,319,429...108,330,023
Ensembl chr 7:108,319,434...108,329,934 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CREB1 mRNA CTD PMID:15477007 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA] CTD PMID:15477007 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Cul5 cullin 5 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] CTD PMID:15477007 NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which affects the localization of CYCS protein] CTD PMID:18056745 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of DNAJB1 mRNA CTD PMID:15477007 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dusp4 dual specificity phosphatase 4 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]] CTD PMID:15477007 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Egr2 early growth response 2 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA] CTD PMID:15477007 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Egr3 early growth response 3 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of EGR3 mRNA CTD PMID:15477007 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of FASN mRNA] CTD PMID:24170205 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:22842628 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOS protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]] CTD PMID:15477007 PMID:17032174 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fyb1 FYN binding protein 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA] CTD PMID:15477007 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629 		JBrowse link
G Gfra2 GDNF family receptor alpha 2 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GFRA2 mRNA] CTD PMID:15477007 NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714 		JBrowse link
G Gnas GNAS complex locus multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GNAS mRNA CTD PMID:15477007 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GTF2H2C mRNA CTD PMID:15477007 NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HADHA mRNA] CTD PMID:15477007 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA] CTD PMID:15477007 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein CTD PMID:21242307 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HNRNPUL1 mRNA CTD PMID:15477007 NCBI chr 1:81,228,404...81,264,121
Ensembl chr 1:81,228,404...81,262,592 		JBrowse link
G Hpx hemopexin multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HSPA8 mRNA; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA8 mRNA]] CTD PMID:15477007 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hyal3 hyaluronidase 3 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HYAL3 mRNA CTD PMID:15477007 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]] CTD PMID:15477007 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]] CTD PMID:23134680 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RB mRNA] CTD PMID:15477007 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN protein]] CTD PMID:15477007 PMID:17032174 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA] CTD PMID:15477007 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of LDLR mRNA] CTD PMID:24170205 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Ltbp4 latent transforming growth factor beta binding protein 4 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA] CTD PMID:15477007 NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK1 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]		 CTD PMID:10658192 PMID:15477007 PMID:22842628 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK3 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK3 protein]		 CTD PMID:10941151 PMID:15477007 PMID:22842628 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK8 protein] CTD PMID:10941151 PMID:11239917 PMID:18056745 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mta1 metastasis associated 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MTA1 mRNA CTD PMID:15477007 NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MYC mRNA] CTD PMID:15477007 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NAA80 mRNA] CTD PMID:15477007 NCBI chr 8:108,254,314...108,257,564
Ensembl chr 8:108,253,302...108,257,563 		JBrowse link
G Nell1 neural EGFL like 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA] CTD PMID:15477007 NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of NFE2L2 mRNA CTD PMID:15477007 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] CTD PMID:11006087 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] CTD PMID:11006087 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nmi N-myc (and STAT) interactor multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NMI mRNA] CTD PMID:15477007 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NR4A3 mRNA] CTD PMID:15477007 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ODC1 mRNA CTD PMID:15477007 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pax8 paired box 8 multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA] CTD PMID:11108245 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO bathocuproine sulfonate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of PPP1R10 mRNA CTD PMID:15477007 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
G Prnp prion protein multiple interactions EXP bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA] CTD PMID:15477007 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 increases oxidation ISO bathocuproine sulfonate results in increased oxidation of SCO1 protein CTD PMID:23345593 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
G Sla src-like adaptor multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLA mRNA] CTD PMID:15477007 NCBI chr 7:98,534,431...98,584,810
Ensembl chr 7:98,535,368...98,584,648 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO [bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA; bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc31a2 solute carrier family 31 member 2 multiple interactions
affects localization		 ISO [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] which results in increased uptake of and results in increased susceptibility to Cisplatin; [bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein
bathocuproine sulfonate affects the localization of SLC31A2 protein
ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein]		 CTD PMID:20194531 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542 		JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SNRNP70 mRNA CTD PMID:15477007 NCBI chr 1:95,856,039...95,876,434
Ensembl chr 1:95,856,036...95,876,392 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SOD1 mRNA CTD PMID:15477007 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Srgn serglycin multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SRGN mRNA CTD PMID:15477007 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406 		JBrowse link
G Srpra SRP receptor subunit alpha multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRPRA mRNA] CTD PMID:15477007 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:11006087 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA] CTD PMID:15477007 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid results in increased abundance of Copper] which results in increased oxidation of and results in increased expression of TP53 protein] CTD PMID:11964141 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpo thyroid peroxidase multiple interactions EXP bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA] CTD PMID:11108245 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]] CTD PMID:15477007 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Tyr tyrosinase multiple interactions ISO bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TYROBP mRNA] CTD PMID:15477007 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBE2L6 mRNA CTD PMID:15477007 NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048 		JBrowse link
G Ubl4a ubiquitin-like 4A multiple interactions ISO [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBL4A mRNA CTD PMID:15477007 NCBI chr  X:152,151,242...152,154,094
Ensembl chr  X:152,151,460...152,154,069 		JBrowse link
G Vim vimentin multiple interactions ISO [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VIM mRNA] CTD PMID:15477007 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
corilagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30582900 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP corilagin inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; corilagin increases expression of nr1h4 mRNA and protein in rat embryonic liver cells RGD PMID:29235094 RGD:15042872 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO corilagin results in decreased secretion of TNF protein CTD PMID:12628509 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
dactolisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression
decreases phosphorylation
multiple interactions		 ISO dactolisib results in decreased expression of AKT1 protein modified form
dactolisib results in decreased phosphorylation of AKT1 protein
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]		 CTD PMID:19435893 PMID:21464613 PMID:22415236 PMID:22949526 PMID:23151917 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib affects the folding of and results in increased activity of BAX protein; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein] CTD PMID:23151917 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO dactolisib affects the expression of BCL2L1 protein CTD PMID:25640480 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 BCL2 like 11 affects expression ISO dactolisib affects the expression of BCL2L11 protein CTD PMID:25640480 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO dactolisib results in decreased expression of BIRC5 protein CTD PMID:22729845 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage		 ISO dactolisib results in increased activity of CASP3 protein
Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]		 CTD PMID:21372221 PMID:23151917 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases phosphorylation ISO dactolisib results in decreased phosphorylation of CCND1 protein CTD PMID:23651616 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dactolisib results in increased expression of CDKN1A protein CTD PMID:23651616 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions		 ISO dactolisib affects the localization of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein		 CTD PMID:23151917 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:24758408 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
increases response to substance		 ISO dactolisib results in decreased phosphorylation of EIF4EBP1 protein
Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]
EIF4EBP1 protein modified form results in increased susceptibility to dactolisib		 CTD PMID:21372221 PMID:22415236 PMID:23151917 PMID:25640480 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] CTD PMID:22949526 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases metabolic processing
affects localization		 ISO dactolisib results in increased metabolism of MAP1LC3A protein
dactolisib affects the localization of MAP1LC3A protein		 CTD PMID:23651616 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO dactolisib promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein] CTD PMID:22415236 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO dactolisib promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein] CTD PMID:22415236 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression
multiple interactions		 ISO dactolisib affects the expression of MCL1 protein
[dactolisib co-treated with (+)-JQ1 compound] affects the expression of MCL1 protein		 CTD PMID:25640480 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases response to substance ISO OGT mutant form results in increased susceptibility to dactolisib CTD PMID:23029544 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]
dactolisib results in decreased phosphorylation of OXSR1 protein		 CTD PMID:22949526 NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dactolisib results in increased cleavage of PARP1 protein CTD PMID:21464613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases response to substance
decreases response to substance		 ISO PIK3CA results in increased susceptibility to dactolisib
PIK3CA results in decreased susceptibility to dactolisib		 CTD PMID:21372221 PMID:21633166 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN gene mutant form results in increased susceptibility to dactolisib CTD PMID:21372221 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO dactolisib results in decreased expression of RB1 protein modified form CTD PMID:23651616 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein] CTD PMID:21372221 PMID:21464613 PMID:21498705 PMID:22415236 PMID:23151917 More... NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO dactolisib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21464613 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]
dactolisib results in decreased phosphorylation of SLC12A3 protein		 CTD PMID:22949526 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein] CTD PMID:23151917 PMID:23651616 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]
dactolisib results in decreased phosphorylation of STK39 protein		 CTD PMID:22949526 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]		 CTD PMID:8700121 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]		 CTD PMID:16407456 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]		 CTD PMID:16407456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein		 CTD PMID:25786523 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein CTD PMID:25786523 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing		 EXP
ISO		 [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate		 CTD PMID:2271712 PMID:25786523 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein		 CTD PMID:8700121 PMID:25786523 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA CTD PMID:8700121 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]		 CTD PMID:8700121 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]		 CTD PMID:8700121 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance		 ISO Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] CTD PMID:12548226 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance		 ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate		 CTD PMID:8700121 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prl prolactin increases abundance ISO PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
multiple interactions		 EXP
ISO		 SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]		 CTD PMID:17132213 PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport ISO SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
increases uptake		 ISO SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate		 CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Sts steroid sulfatase affects metabolic processing ISO STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
ellagic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 increases expression ISO Ellagic Acid results in increased expression of ACP3 mRNA CTD PMID:12002526 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:32971123 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Ellagic Acid results in increased expression of AIFM1 protein CTD PMID:23554011 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ellagic Acid results in increased phosphorylation of AKT1 protein CTD PMID:26986492 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
affects binding		 ISO ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein]
Ellagic Acid binds to ALB protein		 CTD PMID:6343536 PMID:25247703 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO Ellagic Acid results in decreased activity of ALKBH2 protein CTD PMID:31088072 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO Ellagic Acid results in decreased expression of APAF1 mRNA CTD PMID:12002526 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 increases expression ISO Ellagic Acid results in increased expression of ASCL1 mRNA CTD PMID:12002526 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Ellagic Acid results in increased expression of ASNS mRNA CTD PMID:12002526 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Ellagic Acid results in increased expression of ATF3 mRNA CTD PMID:12002526 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Ellagic Acid results in increased expression of ATG5 mRNA CTD PMID:12002526 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Ellagic Acid results in increased expression of BAD protein CTD PMID:23554011 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA] CTD PMID:29854611 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Ellagic Acid results in increased expression of BCL2 protein
Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]
[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]		 CTD PMID:20103723 PMID:22386815 PMID:29854611 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Ellagic Acid results in decreased expression of BMP6 mRNA CTD PMID:12002526 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor subunit decreases expression ISO Ellagic Acid results in decreased expression of BRF1 mRNA CTD PMID:12002526 NCBI chr 6:132,034,380...132,081,296
Ensembl chr 6:132,037,272...132,081,278 		JBrowse link
G Calr calreticulin decreases expression ISO Ellagic Acid results in decreased expression of CALR mRNA CTD PMID:12002526 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
decreases activity
decreases expression		 ISO
EXP		 Ellagic Acid results in increased expression of CASP3 mRNA
Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased activity of CASP3 protein]
Ellagic Acid results in increased expression of and results in increased activity of CASP3 protein
Ellagic Acid results in increased activity of CASP3 protein
Ellagic Acid results in decreased activity of CASP3 protein
Ellagic Acid results in decreased expression of CASP3 mRNA		 CTD PMID:12002526 PMID:22386815 PMID:23554011 PMID:23811531 PMID:28815802 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ellagic Acid results in increased expression of and results in increased activity of CASP9 protein CTD PMID:23554011 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP Ellagic Acid results in increased activity of CAT protein
Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]		 CTD PMID:20074268 PMID:24877639 PMID:29864931 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO Ellagic Acid results in decreased secretion of CCL2 protein CTD PMID:20816778 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd14 CD14 molecule decreases expression ISO Ellagic Acid results in decreased expression of CD14 mRNA CTD PMID:20816778 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Ellagic Acid results in decreased expression of CDK1 protein CTD PMID:23554011 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]
[Ellagic Acid co-treated with Quercetin] results in increased expression of CDKN1A mRNA; Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]
Ellagic Acid results in increased expression of CDKN1A protein		 CTD PMID:15735102 PMID:20103723 PMID:23554011 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:32971123 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
decreases activity		 ISO Ellagic Acid results in decreased expression of CYP1A1 mRNA
Ellagic Acid results in decreased activity of CYP1A1 protein		 CTD PMID:19329757 PMID:20816778 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
multiple interactions		 ISO Ellagic Acid results in decreased activity of CYP1B1 protein
[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]		 CTD PMID:19329757 PMID:20103723 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Daxx death-domain associated protein decreases expression ISO Ellagic Acid results in decreased expression of DAXX mRNA CTD PMID:12002526 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression ISO Ellagic Acid results in decreased expression of DFFA mRNA CTD PMID:12002526 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G E4f1 E4F transcription factor 1 increases expression ISO Ellagic Acid results in increased expression of E4F1 mRNA CTD PMID:12002526 NCBI chr10:13,471,478...13,495,018
Ensembl chr10:13,474,456...13,485,974 		JBrowse link
G Egr3 early growth response 3 decreases expression ISO Ellagic Acid results in decreased expression of EGR3 mRNA CTD PMID:12002526 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Endog endonuclease G increases expression ISO Ellagic Acid results in increased expression of ENDOG protein CTD PMID:23554011 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Ellagic Acid results in increased expression of EP300 mRNA CTD PMID:12002526 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 increases expression ISO Ellagic Acid results in increased expression of EPS15 mRNA CTD PMID:12002526 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit increases expression ISO Ellagic Acid results in increased expression of EZH1 mRNA CTD PMID:12002526 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G F12 coagulation factor XII multiple interactions
increases activity		 ISO ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein] CTD PMID:6343536 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO Ellagic Acid results in decreased expression of FGFR1 mRNA CTD PMID:12002526 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Flna filamin A decreases expression ISO Ellagic Acid results in decreased expression of FLNA mRNA CTD PMID:12002526 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein] CTD PMID:24877639 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; [Ellagic Acid co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] CTD PMID:20103723 PMID:32971123 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Ellagic Acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP Ellagic Acid inhibits the reaction [phosalone results in increased activity of GAL protein] CTD PMID:27965107 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 decreases expression ISO Ellagic Acid results in decreased expression of GPLD1 mRNA CTD PMID:12002526 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of GPT protein] CTD PMID:24877639 PMID:29935397 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA] CTD PMID:29935397 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein] CTD PMID:24877639 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression ISO Ellagic Acid results in increased expression of GSTA4 mRNA CTD PMID:12002526 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression EXP Ellagic Acid affects the expression of GSTT1 protein CTD PMID:9855024 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gtf2e2 general transcription factor IIE subunit 2 increases expression ISO Ellagic Acid results in increased expression of GTF2E2 mRNA CTD PMID:12002526 NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 increases expression ISO Ellagic Acid results in increased expression of GTF2H4 mRNA CTD PMID:12002526 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:21762681 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Ellagic Acid results in decreased expression of HIF1A mRNA CTD PMID:12002526 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO Ellagic Acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Ellagic Acid results in increased expression of HMOX1 mRNA; Ellagic Acid results in increased expression of HMOX1 protein
[Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 protein		 CTD PMID:22386815 PMID:23546295 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]; [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene] CTD PMID:20103723 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ier2 immediate early response 2 increases expression ISO Ellagic Acid results in increased expression of IER2 mRNA CTD PMID:12002526 NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IFNG mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IFNG protein] CTD PMID:29854611 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Ellagic Acid results in increased expression of IGFBP2 mRNA CTD PMID:12002526 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 decreases expression ISO Ellagic Acid results in decreased expression of IGFBP4 mRNA CTD PMID:12002526 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO
EXP		 Ellagic Acid results in decreased expression of IL1B mRNA
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IL1B mRNA]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
Ellagic Acid inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]		 CTD PMID:18377686 PMID:20816778 PMID:21762681 PMID:24877639 PMID:27965107 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Ellagic Acid results in decreased expression of IL1R1 mRNA CTD PMID:20816778 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL6 protein] CTD PMID:21762681 PMID:24877639 PMID:27965107 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D increases expression ISO Ellagic Acid results in increased expression of INPP5D mRNA CTD PMID:12002526 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 increases expression ISO Ellagic Acid results in increased expression of IQGAP2 mRNA CTD PMID:12002526 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279 		JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Ellagic Acid results in increased expression of IRF9 mRNA CTD PMID:12002526 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Ellagic Acid results in decreased expression of JUN mRNA; Ellagic Acid results in decreased expression of JUN protein modified form CTD PMID:23811531 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression ISO Ellagic Acid results in increased expression of LITAF mRNA CTD PMID:12002526 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Map1a microtubule-associated protein 1A decreases expression ISO Ellagic Acid results in decreased expression of MAP1A mRNA CTD PMID:12002526 NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO Ellagic Acid results in decreased expression of MAP3K1 mRNA; Ellagic Acid results in decreased expression of MAP3K1 protein CTD PMID:23811531 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:32971123 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 increases expression ISO Ellagic Acid results in increased expression of MAPK11 mRNA CTD PMID:23811531 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of MAPK14 protein] CTD PMID:27965107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:32971123 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK8 protein CTD PMID:15735102 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO [Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK9 protein CTD PMID:15735102 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Ellagic Acid results in decreased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mmd monocyte to macrophage differentiation-associated increases expression ISO Ellagic Acid results in increased expression of MMD mRNA CTD PMID:12002526 NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein; zinc chloride inhibits the reaction [Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein] CTD PMID:21573219 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:32971123 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
increases expression
multiple interactions
affects response to substance		 ISO Ellagic Acid affects the localization of NFE2L2 protein
Ellagic Acid results in increased expression of NFE2L2 mRNA
Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of NFE2L2 mRNA]
[Paraquat co-treated with Ellagic Acid] results in increased expression of and affects the localization of NFE2L2 protein; [Paraquat co-treated with Ellagic Acid] results in increased expression of NFE2L2 mRNA; Ellagic Acid results in increased expression of and affects the localization of NFE2L2 protein
Ellagic Acid results in increased expression of NFE2L2 mRNA; Ellagic Acid results in increased expression of NFE2L2 protein
NFE2L2 protein affects the susceptibility to Ellagic Acid		 CTD PMID:22386815 PMID:23546295 PMID:30503583 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases expression ISO Ellagic Acid results in decreased expression of NFKB2 mRNA CTD PMID:12002526 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nnat neuronatin increases expression ISO Ellagic Acid results in increased expression of NNAT mRNA CTD PMID:12002526 NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834 		JBrowse link
G Nop56 NOP56 ribonucleoprotein decreases expression ISO Ellagic Acid results in decreased expression of NOP56 mRNA CTD PMID:12002526 NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein] CTD PMID:28815802 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression ISO Ellagic Acid results in increased expression of NPAS2 mRNA CTD PMID:12002526 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO Ellagic Acid results in increased expression of NQO1 mRNA; Ellagic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 protein		 CTD PMID:23546295 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Ellagic Acid results in increased activity of NR1I3 protein CTD PMID:21821919 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase decreases activity ISO Ellagic Acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Ellagic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:25247703 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNA] CTD PMID:20103723 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 multiple interactions EXP Ellagic Acid inhibits the reaction [Rotenone results in increased nitrosation of and results in decreased activity of PDIA2 protein] CTD PMID:25247703 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO Ellagic Acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression ISO Ellagic Acid results in decreased expression of PLA2G2A mRNA CTD PMID:20816778 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Plp2 proteolipid protein 2 increases expression ISO Ellagic Acid results in increased expression of PLP2 mRNA CTD PMID:12002526 NCBI chr  X:14,834,249...14,837,648
Ensembl chr  X:14,834,231...14,838,514 		JBrowse link
G Pml PML nuclear body scaffold decreases expression ISO Ellagic Acid results in decreased expression of PML mRNA CTD PMID:12002526 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Ellagic Acid results in decreased expression of PPARD mRNA CTD PMID:12002526 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Ellagic Acid results in increased expression of PPARG protein CTD PMID:23811531 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression		 ISO Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of PPARGC1A mRNA]
Ellagic Acid results in decreased expression of PPARGC1A mRNA		 CTD PMID:30503583 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression ISO Ellagic Acid results in decreased expression of PRKG1 mRNA CTD PMID:12002526 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Ptn pleiotrophin decreases expression
increases expression		 ISO Ellagic Acid results in decreased expression of PTN mRNA
Ellagic Acid results in increased expression of PTN mRNA		 CTD PMID:12002526 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptprn2 protein tyrosine phosphatase, receptor type N2 increases expression ISO Ellagic Acid results in increased expression of PTPRN2 mRNA CTD PMID:12002526 NCBI chr 6:137,439,572...138,191,575
Ensembl chr 6:137,439,540...138,191,575 		JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Ellagic Acid results in decreased expression of RAN mRNA CTD PMID:12002526 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions EXP Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 protein] CTD PMID:27965107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression
multiple interactions		 ISO Ellagic Acid results in increased expression of RECK mRNA; Ellagic Acid results in increased expression of RECK protein
zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]; zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein]		 CTD PMID:21573219 NCBI chr 5:58,102,915...58,169,513
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions		 ISO
EXP		 Ellagic Acid results in decreased expression of RELA mRNA
Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RELA protein]		 CTD PMID:12002526 PMID:24877639 PMID:27965107 PMID:32971123 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression ISO Ellagic Acid results in decreased expression of RGS5 mRNA CTD PMID:12002526 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Ellagic Acid results in decreased expression of SCD mRNA CTD PMID:20816778 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Septin2 septin 2 increases expression ISO Ellagic Acid results in increased expression of SEPTIN2 mRNA CTD PMID:12002526 NCBI chr 9:94,018,141...94,051,386
Ensembl chr 9:94,018,208...94,051,386 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA] CTD PMID:29935397 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Ellagic Acid results in decreased expression of SOD3 mRNA CTD PMID:12002526 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein] CTD PMID:32971123 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression
multiple interactions		 ISO Ellagic Acid results in increased expression of STAR mRNA
Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of STAR mRNA]		 CTD PMID:30503583 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
decreases expression		 ISO Ellagic Acid results in increased expression of STAT3 mRNA
Ellagic Acid results in decreased expression of STAT3 mRNA		 CTD PMID:12002526 PMID:20816778 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Taf1c TATA-box binding protein associated factor, RNA polymerase 1 subunit C decreases expression ISO Ellagic Acid results in decreased expression of TAF1C mRNA CTD PMID:12002526 NCBI chr19:47,652,451...47,658,971
Ensembl chr19:47,652,452...47,658,971 		JBrowse link
G Tcf12 transcription factor 12 increases expression ISO Ellagic Acid results in increased expression of TCF12 mRNA CTD PMID:12002526 NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
increases expression		 ISO
EXP		 Ellagic Acid inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]
Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]
Ellagic Acid results in increased expression of TERT mRNA alternative form		 CTD PMID:19501078 PMID:27965107 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression ISO Ellagic Acid results in decreased expression of TFAM mRNA CTD PMID:12002526 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO
EXP		 Ellagic Acid results in increased expression of TGFB1 mRNA
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]		 CTD PMID:12002526 PMID:24877639 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein] CTD PMID:21762681 PMID:24877639 PMID:27965107 PMID:28815802 PMID:29455002 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions
affects binding		 ISO Ellagic Acid inhibits the reaction [TNFSF11 protein binds to TNFRSF11A protein]
Ellagic Acid binds to TNFRSF11A protein		 CTD PMID:32971123 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
affects binding		 ISO Ellagic Acid inhibits the reaction [TNFSF11 protein binds to TNFRSF11A protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
Ellagic Acid binds to TNFSF11 protein		 CTD PMID:32971123 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:21762681 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO
EXP		 Ellagic Acid results in increased expression of TP53 protein
Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]
Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 protein]		 CTD PMID:15735102 PMID:23554011 PMID:27965107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 decreases expression ISO Ellagic Acid results in decreased expression of UGP2 mRNA CTD PMID:12002526 NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830 		JBrowse link
G Usp4 ubiquitin specific peptidase 4 decreases expression ISO Ellagic Acid results in decreased expression of USP4 mRNA CTD PMID:12002526 NCBI chr 8:109,035,402...109,080,427
Ensembl chr 8:109,036,099...109,080,427 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Ellagic Acid results in increased expression of WARS1 mRNA CTD PMID:12002526 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases expression ISO Ellagic Acid results in decreased expression of WEE1 protein CTD PMID:23554011 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 decreases expression ISO Ellagic Acid results in decreased expression of ZBTB16 mRNA CTD PMID:12002526 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
G Zmym2 zinc finger MYM-type containing 2 increases expression ISO Ellagic Acid results in increased expression of ZMYM2 mRNA CTD PMID:12002526 NCBI chr15:31,035,783...31,108,945
Ensembl chr15:31,035,838...31,109,357 		JBrowse link
fusidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP
ISO		 Fusidic Acid results in decreased activity of ABCB11 protein
Fusidic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:12106615 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27676153 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin] CTD PMID:26888941 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Fusidic Acid results in decreased expression of and results in decreased activity of ABCC2 protein CTD PMID:12106615 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:26888941 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Fusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid] CTD PMID:27676153 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:26888941 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
decreases activity		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid results in decreased activity of SLCO1B3 protein		 CTD PMID:26888941 PMID:27676153 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:27676153 NCBI chr 9:88,801,344...88,808,465 JBrowse link
glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression
decreases activity		 ISO
EXP		 [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Glyburide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glyburide results in increased expression of ABCB11 mRNA
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium		 CTD PMID:11343252 PMID:15465654 PMID:15618715 PMID:19853032 PMID:20147439 More... NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Glyburide results in increased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO Glyburide results in decreased activity of ABCC1 protein CTD PMID:15652236 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Glyburide results in increased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Glyburide results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 increases response to substance
affects binding
multiple interactions		 EXP ABCC8 protein results in increased susceptibility to Glyburide
Glyburide binds to ABCC8 protein; Glyburide binds to ABCC8 protein mutant form
Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]; resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]		 CTD PMID:17138562 PMID:19095654 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 affects binding
decreases activity
multiple interactions		 ISO Glyburide binds to ABCC9 protein mutant form
Glyburide results in decreased activity of ABCC9 protein
[Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein; Estradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]; resveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]		 CTD PMID:17138562 PMID:19095654 PMID:22622455 PMID:28842488 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
decreases export		 ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]; Genistein inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide] CTD PMID:26850786 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Glyburide results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Glyburide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Glyburide inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:10799337 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP
ISO		 Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]		 CTD PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glyburide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Glyburide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Glyburide inhibits the reaction [sodium bisulfide results in increased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein] CTD PMID:21800153 PMID:33724628 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects binding ISO Glyburide binds to ALB protein CTD PMID:20974553 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Glyburide promotes the reaction [1,2-linoleoylphosphatidylcholine results in increased secretion of APOA1 protein]; Glyburide promotes the reaction [Clofibrate results in increased secretion of APOA1 protein] CTD PMID:19717637 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Arg1 arginase 1 multiple interactions EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:33724628 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Glyburide inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:21800153 PMID:33724628 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO		 Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Ozone results in increased cleavage of CASP1 protein]		 CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Glyburide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:16310184 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
Glyburide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]		 CTD PMID:23716880 PMID:24760747 PMID:26700463 PMID:26748309 PMID:28757134 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity		 ISO
EXP		 Glyburide binds to and results in decreased activity of CFTR protein; Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]
Glyburide results in decreased activity of CFTR protein
Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]
Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]; Glyburide inhibits the reaction [CFTR protein affects the transport of Chlorides]		 CTD PMID:14502435 PMID:14967738 PMID:15131065 PMID:15236628 PMID:15371258 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein] CTD PMID:26748309 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cst3 cystatin C multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein] CTD PMID:32375810 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10799337 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]] CTD PMID:27890915 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:25641191 NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of GSR protein] CTD PMID:26748309 PMID:33724628 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:30817903 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP
ISO		 Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]
Glyburide inhibits the reaction [Ozone results in increased expression of IL18 protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]		 CTD PMID:25338942 PMID:32167222 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta affects secretion
multiple interactions		 ISO
EXP		 Glyburide affects the secretion of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Ozone results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL1B protein]		 CTD PMID:15578659 PMID:25338942 PMID:30817903 PMID:32167222 PMID:32375810 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]		 CTD PMID:24760747 PMID:24849676 PMID:26748309 PMID:30817903 PMID:33724628 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions
increases response to substance
increases secretion
increases expression
decreases expression		 ISO
EXP		 [Glyburide co-treated with Glucose] results in increased expression of INS protein; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]
Glyburide results in increased susceptibility to INS protein
Glyburide results in increased expression of INS mRNA
Glyburide results in decreased expression of INS protein		 CTD PMID:3116364 PMID:10430617 PMID:11305519 PMID:15642492 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:33724628 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein] CTD PMID:32522579 PMID:32860822 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Glyburide results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions
decreases response to substance		 ISO Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]
KCNJ11 protein mutant form results in decreased susceptibility to Glyburide		 CTD PMID:15949470 PMID:28842488 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 decreases activity
decreases response to substance		 ISO
EXP		 Glyburide results in decreased activity of KCNJ8 protein
KCNJ8 protein mutant form results in decreased susceptibility to Glyburide		 CTD PMID:20050851 PMID:28842488 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Glyburide inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lyz2 lysozyme 2 decreases secretion
increases secretion		 ISO Glyburide results in decreased secretion of LYZ protein
Glyburide results in increased secretion of LYZ protein		 CTD PMID:15194485 PMID:15234967 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression		 EXP Quercetin promotes the reaction [Glyburide results in increased expression of MAPK1 protein modified form] CTD PMID:20860660 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression		 EXP Quercetin promotes the reaction [Glyburide results in increased expression of MAPK3 protein modified form] CTD PMID:20860660 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Glyburide inhibits the reaction [Paraquat results in increased activity of MPO protein] CTD PMID:25338942 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:32375810 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein] CTD PMID:32522579 PMID:32860822 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP
ISO		 Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Ozone results in increased expression of NLRP3 protein]		 CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]		 CTD PMID:16257489 PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]] CTD PMID:27890915 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Glyburide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pklr pyruvate kinase L/R multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] CTD PMID:29223569 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:30817903 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:25338942 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA mRNA] CTD PMID:33724628 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Glyburide results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 PMID:28391356 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein] CTD PMID:33724628 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:29223569 PMID:33724628 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:16725203 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Snca synuclein alpha multiple interactions ISO Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein] CTD PMID:32375810 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:16725203 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Glyburide results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF protein]		 CTD PMID:16257489 PMID:24760747 PMID:26748309 PMID:30817903 PMID:32375810 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:30817903 PMID:33387473 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity EXP
ISO		 Glyburide results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein CTD PMID:22622455 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
IC-87114 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]
IC 87114 results in decreased phosphorylation of AKT1 protein		 CTD PMID:16179367 PMID:19176369 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein] CTD PMID:22315502 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
decreases phosphorylation		 ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]
IC 87114 results in decreased phosphorylation of FOXO3 protein		 CTD PMID:16179367 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation ISO IC 87114 results in decreased phosphorylation of GSK3A protein CTD PMID:16179367 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO IC 87114 results in decreased phosphorylation of GSK3B protein CTD PMID:16179367 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein] CTD PMID:33711354 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein] CTD PMID:33711354 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:16179367 PMID:33711354 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein] CTD PMID:33711354 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein] CTD PMID:33711354 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]
IC 87114 results in decreased phosphorylation of MAPK1 protein		 CTD PMID:16179367 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]
IC 87114 results in decreased phosphorylation of MAPK3 protein		 CTD PMID:16179367 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity
multiple interactions		 ISO IC 87114 results in decreased activity of PIK3CD protein
IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein]		 CTD PMID:16179367 PMID:33711354 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein] CTD PMID:33711354 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions
increases response to substance		 ISO IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]
PTPN11 protein mutant form results in increased susceptibility to IC 87114		 CTD PMID:22315502 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO IC 87114 results in decreased phosphorylation of RPS6KB1 protein CTD PMID:16179367 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
idelalisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; [idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]; [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein CTD PMID:31445927 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein CTD PMID:31445927 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein CTD PMID:31445927 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]; [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein CTD PMID:31445927 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein CTD PMID:23676220 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein] CTD PMID:31445927 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein CTD PMID:31445927 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO idelalisib decreases expression of Cxcl1 protein in liver and spleen RGD PMID:27999013 RGD:40890273 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance
multiple interactions		 ISO idelalisib affects the susceptibility to FAS protein
FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]		 CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein; [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein; [idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein] CTD PMID:31445927 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
affects expression
increases expression		 ISO [Galactosamine co-treated with Lipopolysaccharides] promotes the reaction [idelalisib results in increased expression of ALT protein]; FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]
idelalisib affects the expression of GPT protein		 CTD PMID:31445927 PMID:31501888 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifng interferon gamma decreases expression ISO idelalisib decreases expression of Ifng protein in liver, spleen and lymph node RGD PMID:27999013 RGD:40890273 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 decreases expression ISO idelalisib decreases expression of Il10 protein in liver, lymph node and spleen RGD PMID:27999013 RGD:40890273 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il4 interleukin 4 decreases expression ISO idelalisib decreases expression of Il4 protein in lymph node RGD PMID:27999013 RGD:40890273 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression ISO idelalisib decreases expression of Il6 protein in liver and spleen RGD PMID:27999013 RGD:40890273 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mir122 microRNA 122 affects expression ISO idelalisib affects the expression of MIR122 mRNA CTD PMID:31501888 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein CTD PMID:23676220 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression
multiple interactions		 ISO idelalisib results in increased expression of PIK3CA mRNA
idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]		 CTD PMID:31522336 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta increases expression
multiple interactions		 ISO idelalisib results in increased expression of PIK3CB mRNA
idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]		 CTD PMID:31522336 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta multiple interactions
increases expression		 ISO idelalisib inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]
idelalisib results in increased expression of PIK3CD mRNA		 CTD PMID:31522336 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases expression ISO idelalisib results in decreased expression of PIK3CG mRNA CTD PMID:31522336 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 increases expression ISO idelalisib results in increased expression of PIK3IP1 mRNA CTD PMID:23676220 NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein] CTD PMID:31445927 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO idelalisib inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]; idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]; idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA] CTD PMID:31522336 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions		 ISO idelalisib results in increased susceptibility to TNF protein
2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; 2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein		 CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 protein CTD PMID:23466342 PMID:27888070 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1B protein		 CTD PMID:18006147 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC1 protein CTD PMID:27888070 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of ABCC2 mRNA] CTD PMID:15896333 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 decreases expression ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC5 protein CTD PMID:23994249 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein] CTD PMID:21712253 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA] CTD PMID:16849647 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of ACTA2 protein] CTD PMID:33895847 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Acvr2b activin A receptor type 2B multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA] CTD PMID:12710931 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein] CTD PMID:19356108 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose] CTD PMID:15550506 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein] CTD PMID:21807062 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:15121739 PMID:16325820 PMID:23300732 PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
multiple interactions
decreases expression		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AHR mRNA		 CTD PMID:22406437 PMID:27020609 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein] CTD PMID:21787718 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases phosphorylation
multiple interactions
decreases expression
decreases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of and results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GW0742 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hemistepsin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Formaldehyde co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [sodium arsenite co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Cisplatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-aminoisoquinolinone co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Capsaicin co-treated with Oxygen deficiency co-treated with Oxygen] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [diallyl trisulfide inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 protein		 CTD PMID:11306697 PMID:11788791 PMID:12438947 PMID:12511591 PMID:12556562 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1S1 protein CTD PMID:17457363 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Angpt1 angiopoietin 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:15763944 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of MKI67 protein] CTD PMID:31838054 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Apln apelin increases expression
multiple interactions
increases secretion		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of APLN mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Eicosapentaenoic Acid results in increased expression of APLN mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased secretion of APLN protein		 CTD PMID:20352620 PMID:21461750 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in increased activity of CASP3 protein]		 CTD PMID:16648635 PMID:19741129 PMID:22186599 PMID:28756148 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein] CTD PMID:16848764 PMID:18214481 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in decreased expression of AQP9 mRNA] CTD PMID:20378617 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methoxyacetic acid promotes the reaction [Testosterone results in increased activity of AR protein]] CTD PMID:16472761 PMID:18486176 PMID:19059400 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arg2 arginase 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of ARG2 protein] CTD PMID:24951775 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]; Cycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]; SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]] CTD PMID:24057571 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO
EXP		 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]]		 CTD PMID:24898257 PMID:31433112 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein] CTD PMID:19038232 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AURKB protein CTD PMID:21530604 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Axin2 axin 2 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased expression of AXIN2 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AXIN2 mRNA		 CTD PMID:31758290 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in decreased activity of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of BAD protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of BAD protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]		 CTD PMID:12438947 PMID:12970779 PMID:14628071 PMID:17123556 PMID:17559149 More... NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Stilbenes analog affects the localization of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased expression of BAX protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with arsenic disulfide] results in increased expression of BAX protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with TNFSF10 protein] results in increased activity of BAX protein; [Arsenic Trioxide co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of BAX protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]		 CTD PMID:15665116 PMID:15942663 PMID:18449500 PMID:20097879 PMID:20386985 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO
EXP		 [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BBC3 protein		 CTD PMID:20856197 PMID:24567336 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
increases phosphorylation		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of BCL2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with arsenic disulfide] results in decreased expression of BCL2 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; BCL2 protein results in decreased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BCL2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of BCL2 protein		 CTD PMID:16018989 PMID:20386985 PMID:20856197 PMID:21130731 PMID:21800153 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of BCL2A1 mRNA] CTD PMID:16256798 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
increases degradation		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in increased expression of BCL2L1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 protein; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of BCL2L1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]		 CTD PMID:14762343 PMID:18789402 PMID:21173233 PMID:21821001 PMID:22046442 More... NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in decreased expression of BCL2L11 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased phosphorylation of BCL2L11 protein; Resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BCL2L11 protein alternative form]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of BCL2L11 protein]]		 CTD PMID:20856197 PMID:21179458 PMID:25471227 PMID:29054700 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA] CTD PMID:16849647 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1A protein results in increased expression of BDKRB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BDKRB1 protein] CTD PMID:29775649 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased chemical synthesis of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]		 CTD PMID:17172126 PMID:17209049 PMID:19962417 PMID:29061316 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BECN1 protein		 CTD PMID:25955216 PMID:30726812 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]] CTD PMID:20856197 PMID:27032576 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC2 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of BIRC2 mRNA]		 CTD PMID:12970779 PMID:14762343 PMID:15065019 PMID:16256798 PMID:19596284 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC3 protein		 CTD PMID:12970779 PMID:14762343 PMID:15339911 PMID:19596284 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
increases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in increased expression of BIRC5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased expression of BIRC5 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 protein; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BIRC5 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]		 CTD PMID:15065019 PMID:16222118 PMID:17472962 PMID:17548900 PMID:18606715 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]] CTD PMID:18495116 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Btc betacellulin multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein] CTD PMID:19105244 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] CTD PMID:19808899 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in decreased susceptibility to Etoposide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in increased expression of BIRC5 protein] CTD PMID:16222118 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CAMP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]] CTD PMID:24039193 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased cleavage of CASP1 protein]
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased cleavage of CASP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP1 protein		 CTD PMID:25929181 PMID:30726812 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]] CTD PMID:19801490 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in decreased expression of CASP3 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased activity of and results in increased localization of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of and results in increased activity of CASP3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with gemcitabine] affects the activity of CASP3 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein; [U 0126 co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP3 protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; Boc-D-FMK inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of CASP3 protein		 CTD PMID:14687664 PMID:14688022 PMID:15695173 PMID:15850772 PMID:15942663 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]] CTD PMID:19801490 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 multiple interactions EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP6 protein]		 CTD PMID:17341418 PMID:19801490 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases activity
increases cleavage
multiple interactions		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP7 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP7 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased activity of CASP7 protein]		 CTD PMID:14687664 PMID:14688022 PMID:16487511 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP8 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]] CTD PMID:15850772 PMID:15942663 PMID:20856197 PMID:27032576 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased activity of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of CASP9 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP9 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]]		 CTD PMID:12438947 PMID:15850772 PMID:16412023 PMID:17341418 PMID:19801490 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in decreased expression of CAT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]] CTD PMID:22040890 PMID:32602595 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein] CTD PMID:11980903 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]		 CTD PMID:16794257 PMID:19293636 PMID:19446813 PMID:20354174 PMID:22225513 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] CTD PMID:22225513 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein] CTD PMID:21055460 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of CCN2 mRNA]]		 CTD PMID:26054450 PMID:33270355 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNA2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNA2 protein]		 CTD PMID:14971663 PMID:17148679 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CCNB1 protein] CTD PMID:32877639 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of CCND1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased expression of CCND1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in decreased expression of CCND1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]		 CTD PMID:14750165 PMID:14757120 PMID:15695173 PMID:16412023 PMID:17148679 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
decreases methylation
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased methylation of CCND2 promoter
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CCND2 mRNA		 CTD PMID:14745455 PMID:15601625 PMID:15778701 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND3 protein		 CTD PMID:14757120 PMID:15601625 PMID:15778701 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein		 CTD PMID:14757120 PMID:14971663 PMID:15601625 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein] CTD PMID:26163174 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd274 CD274 molecule decreases expression
multiple interactions		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CD274 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CD274 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [nano-diamino-tetrac results in decreased expression of CD274 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [nano-diamino-tetrac results in decreased expression of CD274 protein]; nano-diamino-tetrac promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CD274 protein]		 CTD PMID:29960019 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CD36 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA] CTD PMID:19640849 PMID:25712622 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd38 CD38 molecule multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA] CTD PMID:22556157 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]] CTD PMID:33396024 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CDC25C protein] CTD PMID:32877639 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDH1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]		 CTD PMID:23921149 PMID:25118938 PMID:25656647 PMID:26089345 PMID:26363213 More... NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:24997338 PMID:30609689 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CDK1 protein] CTD PMID:32877639 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk16 cyclin-dependent kinase 16 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDK16 mRNA] CTD PMID:12710931 NCBI chr  X:1,492,814...1,504,309
Ensembl chr  X:1,492,814...1,504,148 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDK4 protein] CTD PMID:27312872 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased expression of and affects the localization of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased stability of CDKN1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Resveratrol co-treated with Clofarabine] results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased expression of CDKN1A protein]		 CTD PMID:15001399 PMID:15695173 PMID:17148679 PMID:23146690 PMID:25791921 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO [decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA; [resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CDKN1B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1B protein		 CTD PMID:11322924 PMID:15601625 PMID:17148679 PMID:18622747 PMID:21179458 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2A mRNA] CTD PMID:12710931 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2D mRNA] CTD PMID:12710931 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Cdx2 caudal type homeo box 2 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA] CTD PMID:15350541 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142