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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
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Accession:CHEBI:76843 term browser browse the term
Definition:An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme with reduced iron-sulfur protein as one donor and incorporating one atom of oxygen (EC 1.14.15.*).
Synonyms:related_synonym: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitors;   EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitors;   EC 1.14.15.* inhibitor;   EC 1.14.15.* inhibitors;   oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitor


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metyrapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression
increases activity
multiple interactions		 ISO Metyrapone results in increased expression of ABCC3 mRNA
Metyrapone results in increased activity of ABCC3 protein
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA		 CTD PMID:14570758 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein] CTD PMID:19819344 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] affects the localization of CASP4 protein CTD PMID:19819344 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 protein] CTD PMID:27037194 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of CEBPB mRNA CTD PMID:37088303 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of CXCL1 protein] CTD PMID:27037194 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:16935330 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein] CTD PMID:11856816 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Metyrapone results in increased expression of CYP2B2 mRNA CTD PMID:16125621 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 multiple interactions EXP Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Metyrapone co-treated with Metyrapone] results in increased expression of DDIT3 protein; Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein] CTD PMID:19819344 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Metyrapone CTD PMID:24246760 NCBI chr12:72,697,127...72,711,678
Ensembl chr12:72,697,127...72,711,683 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of FOS mRNA CTD PMID:37088303 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Hif3a hypoxia inducible factor 3, alpha subunit multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] CTD PMID:27037194 NCBI chr 7:16,764,918...16,796,352
Ensembl chr 7:16,765,432...16,796,352 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of HK2 mRNA CTD PMID:37088303 NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of HMOX1 mRNA] CTD PMID:27037194 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO Metyrapone results in decreased activity of HSD11B1 protein CTD PMID:10664531 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Metyrapone results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression
multiple interactions		 ISO Metyrapone results in decreased expression of HSD17B1 mRNA
[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA		 CTD PMID:16935330 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein] CTD PMID:19819344 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of IGFBP1 mRNA CTD PMID:37088303 NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of IL10 protein] CTD PMID:27037194 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein] CTD PMID:27037194 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 protein] CTD PMID:27037194 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased phosphorylation of IRS1 protein CTD PMID:37088303 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] affects the expression of JUN mRNA CTD PMID:37088303 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of KRAS mRNA CTD PMID:37088303 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Lep leptin multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA CTD PMID:37088303 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor increases expression ISO Metyrapone increases Lepr mRNA expression in placenta RGD PMID:12297537 RGD:10412034 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] results in increased expression of MAP1LC3B protein CTD PMID:19819344 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO
EXP		 [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:14570758 PMID:16919048 PMID:17041008 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO
EXP		 Metyrapone results in increased activity of NR1I3 protein CTD PMID:16919048 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in decreased expression of PCK2 mRNA CTD PMID:37088303 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of PGK1 mRNA CTD PMID:37088303 NCBI chr  X:105,230,706...105,247,305
Ensembl chr  X:105,230,706...105,247,305 		JBrowse link
G Pomc pro-opiomelanocortin-alpha increases expression ISO Metyrapone results in increased expression of POMC protein CTD PMID:638031 PMID:16566900 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SERPINE1 mRNA CTD PMID:37088303 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions ISO Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SGK1 mRNA] CTD PMID:31520820 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SHC1 mRNA CTD PMID:37088303 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]
Metyrapone inhibits the reaction [Ozone results in increased expression of TNF mRNA]		 CTD PMID:11856816 PMID:27037194 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TSC22D3 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of TSC22D3 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr  X:139,440,277...139,501,257
Ensembl chr  X:139,440,277...139,501,408 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of VEGFA mRNA CTD PMID:37088303 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          enzyme inhibitor 19910
            EC 1.* (oxidoreductase) inhibitor 18016
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 16421
                EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor 42
                  EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor + 0
                  EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor + 42
                  EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) inhibitor + 0
paths to the root