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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
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Accession:CHEBI:76834 term browser browse the term
Definition:An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*).
Synonyms:related_synonym: EC 2.5.* inhibitor;   EC 2.5.* inhibitors;   non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors


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chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552 		JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116 		JBrowse link
glyphosate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression
multiple interactions		 EXP glyphosate results in increased expression of ATF4 mRNA; glyphosate results in increased expression of ATF4 protein
Betaine inhibits the reaction [glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of ATF4 protein]		 CTD PMID:36584959 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G ATF6 activating transcription factor 6 increases expression
multiple interactions		 EXP glyphosate results in increased expression of ATF6 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of ATF6 mRNA]		 CTD PMID:36584959 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP [Betaine co-treated with glyphosate] results in increased expression of BAX mRNA
glyphosate results in increased expression of BAX mRNA		 CTD PMID:36584959 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions		 EXP glyphosate results in increased expression of CASP3 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of CASP3 mRNA]		 CTD PMID:36584959 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP9 caspase 9 increases expression
multiple interactions		 EXP glyphosate results in increased expression of CASP9 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of CASP9 mRNA]		 CTD PMID:36584959 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G CAT catalase increases activity
multiple interactions
increases expression		 EXP glyphosate results in increased activity of CAT protein
Betaine inhibits the reaction [glyphosate results in increased expression of CAT mRNA]		 CTD PMID:31677563 PMID:36584959 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CLDN1 claudin 1 decreases expression
multiple interactions		 EXP glyphosate results in decreased expression of CLDN1 mRNA; glyphosate results in decreased expression of CLDN1 protein
Betaine inhibits the reaction [glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [glyphosate results in decreased expression of CLDN1 protein]		 CTD PMID:31677563 PMID:36584959 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions		 EXP glyphosate results in increased expression of CXCL8 mRNA
pyrrolidine dithiocarbamic acid inhibits the reaction [glyphosate results in increased expression of CXCL8 mRNA]		 CTD PMID:35388968 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression		 EXP Betaine inhibits the reaction [glyphosate results in increased expression of DDIT3 mRNA] CTD PMID:36584959 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions		 EXP glyphosate results in increased expression of EIF2AK3 mRNA; glyphosate results in increased expression of EIF2AK3 protein
Betaine inhibits the reaction [glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of EIF2AK3 protein]		 CTD PMID:36584959 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases expression		 EXP Betaine inhibits the reaction [glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of EIF2S1 protein]
glyphosate results in increased expression of EIF2S1 mRNA; glyphosate results in increased expression of EIF2S1 protein		 CTD PMID:36584959 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression		 EXP Betaine inhibits the reaction [glyphosate results in increased expression of ERN1 mRNA] CTD PMID:36584959 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases expression EXP glyphosate results in decreased expression of GCLM mRNA CTD PMID:31677563 PMID:35388968 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131 		JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression
decreases activity		 EXP glyphosate results in decreased expression of GPX1 mRNA
glyphosate results in decreased activity of GPX1 protein		 CTD PMID:31677563 PMID:35388968 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions EXP [Betaine co-treated with glyphosate] results in increased expression of GPX2 mRNA CTD PMID:36584959 NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases expression EXP glyphosate results in increased expression of GSTO1 mRNA CTD PMID:36584959 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613 		JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
multiple interactions
increases expression		 EXP glyphosate results in decreased expression of HMOX1 mRNA
glyphosate results in increased expression of and affects the localization of HMOX1 protein
glyphosate results in increased expression of HMOX1 mRNA		 CTD PMID:31677563 PMID:35388968 PMID:36584959
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
multiple interactions		 EXP glyphosate results in increased expression of HSP90B1 mRNA; glyphosate results in increased expression of HSP90B1 protein
Betaine inhibits the reaction [glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of HSP90B1 protein]		 CTD PMID:36584959 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G IL10 interleukin 10 increases expression EXP glyphosate results in increased expression of IL10 protein CTD PMID:36584959 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
affects secretion		 EXP glyphosate results in increased expression of IL6 mRNA; glyphosate results in increased expression of IL6 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [glyphosate results in increased expression of IL6 mRNA]
glyphosate affects the secretion of IL6 protein		 CTD PMID:31677563 PMID:35388968 PMID:36584959 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 decreases expression EXP glyphosate results in decreased expression of KEAP1 mRNA CTD PMID:35388968 NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382 		JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions
increases expression
increases secretion		 EXP pyrrolidine dithiocarbamic acid inhibits the reaction [glyphosate results in increased expression of IL1B mRNA]
glyphosate results in increased expression of IL1B mRNA; glyphosate results in increased expression of IL1B protein
glyphosate results in increased secretion of IL1B protein		 CTD PMID:35388968 PMID:36584959
G MFN1 mitofusin 1 multiple interactions
increases expression		 EXP Betaine inhibits the reaction [glyphosate results in increased expression of MFN1 mRNA] CTD PMID:36584959 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 EXP glyphosate results in increased expression of NFE2L2 mRNA; glyphosate results in increased expression of NFE2L2 protein
Betaine inhibits the reaction [glyphosate results in increased expression of NFE2L2 mRNA]; glyphosate results in increased expression of and affects the localization of NFE2L2 protein		 CTD PMID:31677563 PMID:35388968 PMID:36584959 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression EXP glyphosate results in increased expression of NFKB1 mRNA CTD PMID:31677563 PMID:35388968 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP glyphosate results in decreased expression of and results in increased phosphorylation of NFKBIA protein CTD PMID:35388968 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NOS2 nitric oxide synthase 2 increases expression EXP glyphosate results in increased expression of NOS2 mRNA CTD PMID:35388968 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP glyphosate results in increased expression of NQO1 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of NQO1 mRNA]		 CTD PMID:31677563 PMID:35388968 PMID:36584959 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590 		JBrowse link
G PCNA proliferating cell nuclear antigen increases expression
multiple interactions		 EXP glyphosate results in increased expression of PCNA mRNA; glyphosate results in increased expression of PCNA protein
Betaine inhibits the reaction [glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of PCNA protein]		 CTD PMID:36584959 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases phosphorylation EXP glyphosate results in increased phosphorylation of RELA protein CTD PMID:35388968 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A increases expression
multiple interactions		 EXP glyphosate results in increased expression of SDHA mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of SDHA mRNA]		 CTD PMID:36584959 NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524 		JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP glyphosate results in decreased activity of SOD1 protein CTD PMID:35388968 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression
multiple interactions		 EXP glyphosate results in increased expression of SOD2 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of SOD2 mRNA]		 CTD PMID:36584959 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [glyphosate results in decreased expression of SQSTM1 protein] CTD PMID:35388968 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP glyphosate results in decreased expression of TJP1 mRNA CTD PMID:31677563 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836 		JBrowse link
G TNF tumor necrosis factor affects secretion
increases expression		 EXP glyphosate affects the secretion of TNF protein
glyphosate results in increased expression of TNF protein		 CTD PMID:35388968 PMID:36584959 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G UQCRB ubiquinol-cytochrome c reductase binding protein multiple interactions EXP [Betaine co-treated with glyphosate] results in decreased expression of UQCRB mRNA CTD PMID:36584959 NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057 		JBrowse link
G XBP1 X-box binding protein 1 multiple interactions
increases expression		 EXP Betaine inhibits the reaction [glyphosate results in increased expression of XBP1 mRNA] CTD PMID:36584959 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
hypochlorous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions EXP Hypochlorous Acid inhibits the reaction [NOS3 protein binds to NOS3 protein] CTD PMID:17762155 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
phenethyl caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein] CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP rosmarinic acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression EXP sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein CTD PMID:16005169 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein CTD PMID:16005169 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5029
    role 4992
      biological role 4992
        biochemical role 4912
          enzyme inhibitor 481
            EC 2.* (transferase) inhibitor 136
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 45
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor + 45
paths to the root