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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
EXP |
Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein] |
CTD |
PMID:25813982 PMID:31300867 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Egf |
epidermal growth factor |
multiple interactions |
EXP |
Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein] |
CTD |
PMID:25813982 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA |
CTD |
PMID:11992407 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Gzmb |
granzyme B |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA |
CTD |
PMID:11992407 |
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NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein |
CTD |
PMID:11992407 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein |
CTD |
PMID:11992407 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Prf1 |
perforin 1 |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA |
CTD |
PMID:11992407 |
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NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:11992407 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Dipyridamole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Dipyridamole results in decreased activity of ABCB11 protein |
CTD |
PMID:23956101 PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
decreases activity multiple interactions |
ISO |
Dipyridamole results in decreased activity of ABCC4 protein Dipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP] |
CTD |
PMID:11856762 PMID:15827327 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Adora3 |
adenosine A3 receptor |
increases expression |
EXP |
Dipyridamole results in increased expression of ADORA3 protein |
CTD |
PMID:17101059 |
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NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein |
CTD |
PMID:19603250 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] |
CTD |
PMID:20063052 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Casp1 |
caspase 1 |
increases activity |
EXP |
Dipyridamole results in increased activity of CASP1 protein |
CTD |
PMID:21832250 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] |
CTD |
PMID:17303086 PMID:22700542 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases activity multiple interactions |
ISO |
Dipyridamole results in increased activity of CASP7 protein Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
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NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] |
CTD |
PMID:17303086 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP ISO |
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]] Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] |
CTD |
PMID:16765938 PMID:20940016 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cd40lg |
CD40 ligand |
decreases secretion |
ISO |
Dipyridamole results in decreased secretion of CD40LG protein |
CTD |
PMID:16046616 |
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NCBI chr X:135,127,119...135,138,302
Ensembl chr X:135,126,969...135,138,306
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] |
CTD |
PMID:17303086 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cldn5 |
claudin 5 |
increases expression |
ISO |
Dipyridamole results in increased expression of CLDN5 mRNA |
CTD |
PMID:20711499 |
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NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
ISO EXP |
Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] Dipyridamole results in decreased expression of COL1A1 mRNA |
CTD |
PMID:7617123 PMID:11576339 PMID:12271277 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] |
CTD |
PMID:11576339 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
ISO |
Dipyridamole results in decreased expression of CXCL12 mRNA |
CTD |
PMID:20711499 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] |
CTD |
PMID:20063052 |
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NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases phosphorylation multiple interactions |
ISO EXP |
Dipyridamole results in increased phosphorylation of DUSP1 protein DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein] DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] |
CTD |
PMID:16765938 PMID:19356721 |
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NCBI chr10:16,680,489...16,683,276
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G |
Enpp1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
decreases expression |
EXP |
Dipyridamole results in decreased expression of ENPP1 protein |
CTD |
PMID:21414308 |
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NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
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G |
Fadd |
Fas associated via death domain |
increases expression multiple interactions |
ISO |
Dipyridamole results in increased expression of FADD mRNA Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA] |
CTD |
PMID:17303086 |
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NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Dipyridamole results in increased expression of FOS mRNA |
CTD |
PMID:12730611 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP |
Dipyridamole results in increased expression of HMOX1 protein HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein] |
CTD |
PMID:19356721 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
Dipyridamole results in decreased expression of ICAM1 mRNA |
CTD |
PMID:20711499 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein] |
CTD |
PMID:16765938 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]; KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]; KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] |
CTD |
PMID:8904084 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
decreases expression |
ISO |
Dipyridamole results in decreased expression of IL2 mRNA |
CTD |
PMID:20711499 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:16765938 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Insr |
insulin receptor |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] |
CTD |
PMID:15694368 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dipyridamole results in decreased activity of KCNH2 protein |
CTD |
PMID:17146843 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Lep |
leptin |
multiple interactions increases expression |
EXP |
1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] |
CTD |
PMID:10746648 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases activity |
ISO |
Dipyridamole results in increased activity of MAPK8 protein |
CTD |
PMID:11051267 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:16765938 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
EXP ISO |
Dipyridamole results in increased expression of NOS2 mRNA; Dipyridamole results in increased expression of NOS2 protein Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:8904084 PMID:12271277 PMID:16765938 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nppb |
natriuretic peptide B |
increases expression |
ISO |
Dipyridamole results in increased expression of NPPB protein |
CTD |
PMID:18037770 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] |
CTD |
PMID:25257666 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Orm1 |
orosomucoid 1 |
multiple interactions affects binding |
ISO |
Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form] Dipyridamole binds to ORM1 protein alternative form |
CTD |
PMID:8946472 |
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NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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G |
Pde10a |
phosphodiesterase 10A |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP] |
CTD |
PMID:10373451 |
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NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
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G |
Pde11a |
phosphodiesterase 11A |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP] |
CTD |
PMID:10725373 |
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NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158
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G |
Pde4b |
phosphodiesterase 4B |
increases expression |
ISO |
Dipyridamole results in increased expression of PDE4B mRNA |
CTD |
PMID:20711499 |
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NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
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G |
Pde5a |
phosphodiesterase 5A |
decreases activity |
ISO |
Dipyridamole results in decreased activity of PDE5A protein |
CTD |
PMID:11051267 |
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NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Pde7a |
phosphodiesterase 7A |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] |
CTD |
PMID:10618442 |
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NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
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G |
Pde7b |
phosphodiesterase 7B |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] |
CTD |
PMID:10618442 PMID:10814504 PMID:10872825 |
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NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
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G |
Pde8a |
phosphodiesterase 8A |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP] Dipyridamole inhibits the reaction [PDE8A protein results in increased hydrolysis of Cyclic AMP] |
CTD |
PMID:9671792 PMID:12681444 |
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NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
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G |
Pde8b |
phosphodiesterase 8B |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] |
CTD |
PMID:9784418 PMID:12681444 |
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NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
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G |
Plat |
plasminogen activator, tissue type |
increases secretion multiple interactions |
ISO |
Dipyridamole results in increased secretion of PLAT protein KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] |
CTD |
PMID:15733978 |
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NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; triptolide inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] |
CTD |
PMID:16765938 PMID:20940016 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rcan1 |
regulator of calcineurin 1 |
affects binding |
ISO |
Dipyridamole binds to RCAN1 protein alternative form |
CTD |
PMID:19189965 |
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NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Dipyridamole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc29a1 |
solute carrier family 29 member 1 |
multiple interactions decreases activity |
ISO |
Dipyridamole inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]] Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine] Dipyridamole results in decreased activity of SLC29A1 protein |
CTD |
PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 PMID:11179696 PMID:21678404 PMID:21872611 PMID:28041785 More...
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NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
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G |
Slc29a2 |
solute carrier family 29 member 2 |
multiple interactions |
ISO |
Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]] Dipyridamole inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] |
CTD |
PMID:10366666 PMID:11085929 |
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NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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|
G |
Slc4a1 |
solute carrier family 4 member 1 (Diego blood group) |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides] |
CTD |
PMID:2511191 |
|
NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
EXP |
Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]; Dipyridamole inhibits the reaction [Glucose results in increased expression of SPP1 mRNA]; Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]] |
CTD |
PMID:19356721 PMID:20453393 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] |
CTD |
PMID:11576339 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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|
G |
Th |
tyrosine hydroxylase |
decreases expression |
EXP |
Dipyridamole results in decreased expression of TH protein |
CTD |
PMID:17568153 |
|
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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|
G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
Dipyridamole results in decreased expression of TNF mRNA |
CTD |
PMID:20711499 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Txn1 |
thioredoxin 1 |
multiple interactions |
EXP |
Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] |
CTD |
PMID:20453393 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
ISO |
Dipyridamole inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] |
CTD |
PMID:30237061 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
Dipyridamole results in decreased expression of VCAM1 mRNA |
CTD |
PMID:20711499 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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|
G |
Vegfa |
vascular endothelial growth factor A |
increases secretion multiple interactions |
ISO |
Dipyridamole results in increased secretion of VEGFA protein Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] |
CTD |
PMID:20067761 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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|
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:16757516 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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|
G |
Adam9 |
ADAM metallopeptidase domain 9 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] |
CTD |
PMID:17018608 |
|
NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
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|
G |
Afp |
alpha-fetoprotein |
multiple interactions |
EXP |
ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA] |
CTD |
PMID:11133813 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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|
G |
Alad |
aminolevulinate dehydratase |
multiple interactions decreases activity |
EXP ISO |
Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein] ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein] |
CTD |
PMID:14630126 PMID:17624921 PMID:23933410 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alox5 |
arachidonate 5-lipoxygenase |
decreases activity |
ISO |
ebselen results in decreased activity of ALOX5 protein |
CTD |
PMID:7590103 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein] |
CTD |
PMID:30558456 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] |
CTD |
PMID:30558456 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein] ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein] ebselen results in increased activity of CASP3 protein |
CTD |
PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO EXP |
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein] ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] |
CTD |
PMID:18629305 PMID:23649643 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Cat |
catalase |
increases activity multiple interactions |
EXP |
ebselen results in increased activity of CAT protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] |
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cox4i1 |
cytochrome c oxidase subunit 4i1 |
increases expression |
ISO |
ebselen results in increased expression of COX4I1 protein |
CTD |
PMID:27385396 |
|
NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
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G |
Cs |
citrate synthase |
multiple interactions |
ISO EXP |
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein] |
CTD |
PMID:27385396 PMID:32860823 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:27282967 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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|
G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
ebselen binds to and results in decreased activity of EPHX2 protein |
CTD |
PMID:23219563 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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|
G |
Fmr1 |
fragile X messenger ribonucleoprotein 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] |
CTD |
PMID:27385396 |
|
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
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|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] |
CTD |
PMID:14572605 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein] |
CTD |
PMID:32860823 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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|
G |
Gck |
glucokinase |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased activity of GCK protein |
CTD |
PMID:23795780 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gfap |
glial fibrillary acidic protein |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of GFAP protein |
CTD |
PMID:27282967 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein] |
CTD |
PMID:12958040 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein] |
CTD |
PMID:23795780 PMID:28383113 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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|
G |
Gsr |
glutathione-disulfide reductase |
increases activity multiple interactions |
EXP |
ebselen results in increased activity of GSR protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] |
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]; ebselen binds to and results in decreased activity of GSTA3 protein |
CTD |
PMID:8147899 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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|
G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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|
G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of GSTP1 protein |
CTD |
PMID:8147899 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]] |
CTD |
PMID:19374849 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
[ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein |
CTD |
PMID:16959961 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hpgds |
hematopoietic prostaglandin D synthase |
increases expression |
ISO |
ebselen results in increased expression of HPGDS mRNA |
CTD |
PMID:21669866 |
|
NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
ebselen results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] |
CTD |
PMID:12794164 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] |
CTD |
PMID:30558456 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases activity increases phosphorylation |
ISO EXP |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen results in increased activity of MAPK1 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases activity increases phosphorylation |
ISO EXP |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] ebselen results in increased activity of MAPK3 protein ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:27282967 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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|
G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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|
G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases activity |
ISO EXP |
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] ebselen results in decreased activity of NOS2 protein |
CTD |
PMID:7590103 PMID:12794164 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
decreases activity |
EXP |
ebselen results in decreased activity of NQO1 protein |
CTD |
PMID:7590103 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Pdx1 |
pancreatic and duodenal homeobox 1 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased expression of PDX1 protein |
CTD |
PMID:23795780 |
|
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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G |
Phospho1 |
phosphoethanolamine/phosphocholine phosphatase 1 |
decreases activity |
ISO |
ebselen results in decreased activity of PHOSPHO1 protein |
CTD |
PMID:17227223 |
|
NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] |
CTD |
PMID:14572605 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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|
G |
Slc11a2 |
solute carrier family 11 member 2 |
multiple interactions |
ISO |
ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] |
CTD |
PMID:16984886 |
|
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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|
G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions |
ISO EXP |
[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein] |
CTD |
PMID:23795780 PMID:32860823 |
|
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:21131394 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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|
G |
Sod1 |
superoxide dismutase 1 |
decreases response to substance multiple interactions |
ISO |
ebselen results in decreased susceptibility to SOD1 protein mutant form ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] |
CTD |
PMID:16702190 PMID:23795780 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein] |
CTD |
PMID:32860823 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:11903743 PMID:16757516 PMID:21131394 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:11903743 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein] |
CTD |
PMID:30558456 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
ISO |
ebselen results in increased expression of and results in increased activity of TXNRD1 protein |
CTD |
PMID:28383113 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein |
CTD |
PMID:23795780 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Xbp1 |
X-box binding protein 1 |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of XBP1 protein |
CTD |
PMID:27282967 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Xpa |
XPA, DNA damage recognition and repair factor |
multiple interactions |
ISO |
ebselen inhibits the reaction [Zinc binds to XPA protein] |
CTD |
PMID:15265038 |
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NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
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