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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor
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Accession:CHEBI:76808 term browser browse the term
Definition:An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*).
Synonyms:related_synonym: EC 3.5.2.* inhibitor;   EC 3.5.2.* inhibitors;   non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors;   non-peptide cyclic amide C-N hydrolase inhibitor;   non-peptide cyclic amide C-N hydrolase inhibitors


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ceftriaxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP Ceftriaxone results in decreased expression of ACE2 mRNA CTD PMID:29745864 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Actb actin, beta increases expression EXP Ceftriaxone results in increased expression of ACTB mRNA CTD PMID:29745864 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Bace1 beta-secretase 1 decreases expression EXP Ceftriaxone results in decreased expression of BACE1 mRNA CTD PMID:29745864 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO
EXP
Ceftriaxone results in decreased expression of CAT protein
Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD PMID:19442074, PMID:25053526 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Ceftriaxone results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Ceftriaxone results in increased expression of ECE1 mRNA CTD PMID:29745864 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Epo erythropoietin increases expression EXP Ceftriaxone results in increased expression of EPO mRNA CTD PMID:29745864 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ide insulin degrading enzyme increases expression EXP Ceftriaxone results in increased expression of IDE mRNA CTD PMID:29745864 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]] CTD PMID:25053526 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mme membrane metallo-endopeptidase increases expression EXP Ceftriaxone results in increased expression of MME mRNA CTD PMID:29745864 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP Ceftriaxone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
Ceftriaxone results in increased expression of SLC1A2 protein
CTD PMID:19625514, PMID:19717140, PMID:28257918, PMID:29045497 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein] CTD PMID:19717140 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]] CTD PMID:25053526 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
salsalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 affects expression EXP salicylsalicylic acid affects the expression of IL6 protein CTD PMID:20876710 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein CTD PMID:20876710 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression EXP salicylsalicylic acid affects the expression of RELA protein CTD PMID:20876710 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP salicylsalicylic acid affects the expression of SOD2 protein CTD PMID:20876710 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP salicylsalicylic acid affects the expression of VEGFA protein CTD PMID:20876710 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
tazobactam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions EXP Ozone promotes the reaction [[tazobactam co-treated with Piperacillin] results in increased expression of IL1B mRNA] CTD PMID:16369182 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ozone promotes the reaction [[tazobactam co-treated with Piperacillin] results in increased expression of TNF mRNA] CTD PMID:16369182 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          enzyme inhibitor 18166
            EC 3.* (hydrolase) inhibitor 17662
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 17565
                EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor 18
                  EC 3.5.2.6 (beta-lactamase) inhibitor + 18
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.