CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor
Accession: CHEBI:76808
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Definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*).
Synonyms: related_synonym: EC 3.5.2.* inhibitor; EC 3.5.2.* inhibitors; non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors; non-peptide cyclic amide C-N hydrolase inhibitor; non-peptide cyclic amide C-N hydrolase inhibitors
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA
CTD
PMID:34767876
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of AKR1B10 mRNA
CTD
PMID:34767876
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Casp3
caspase 3
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP3 protein
CTD
PMID:30273099
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP9 protein
CTD
PMID:30273099
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cycs
cytochrome c, somatic
increases secretion
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased secretion of CYCS protein
CTD
PMID:30273099
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP27A1 mRNA
CTD
PMID:34767876
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP7A1 mRNA
CTD
PMID:34767876
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNA
CTD
PMID:34767876
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of FGF19 mRNA
CTD
PMID:34767876
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of G6PD mRNA
CTD
PMID:34767876
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA
CTD
PMID:34767876
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLM mRNA
CTD
PMID:34767876
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Ggt1
gamma-glutamyltransferase 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GGT1 protein
CTD
PMID:34767876
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Got1
glutamic-oxaloacetic transaminase 1
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of GOT1 protein
CTD
PMID:30273099
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of GPT protein
CTD
PMID:30273099
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx2
glutathione peroxidase 2
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GPX2 mRNA
CTD
PMID:34767876
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gsr
glutathione-disulfide reductase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GSR mRNA
CTD
PMID:34767876
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Me1
malic enzyme 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of ME1 mRNA
CTD
PMID:34767876
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of NR0B2 mRNA
CTD
PMID:34767876
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC10A1 mRNA
CTD
PMID:34767876
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc51a
solute carrier family 51 subunit alpha
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC51A mRNA
CTD
PMID:34767876
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA
CTD
PMID:34767876
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Tkt
transketolase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of TKT mRNA
CTD
PMID:34767876
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of TXNRD1 mRNA
CTD
PMID:34767876
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ace2
angiotensin I converting enzyme 2
decreases expression
EXP
Ceftriaxone results in decreased expression of ACE2 mRNA
CTD
PMID:29745864
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Actb
actin, beta
increases expression
EXP
Ceftriaxone results in increased expression of ACTB mRNA
CTD
PMID:29745864
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Bace1
beta-secretase 1
decreases expression
EXP
Ceftriaxone results in decreased expression of BACE1 mRNA
CTD
PMID:29745864
NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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Cat
catalase
decreases expression multiple interactions
ISO EXP
Ceftriaxone results in decreased expression of CAT protein Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD
PMID:19442074 PMID:25053526
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Dhfr
dihydrofolate reductase
decreases activity
ISO
Ceftriaxone results in decreased activity of DHFR protein
CTD
PMID:25418905
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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Ece1
endothelin converting enzyme 1
increases expression
EXP
Ceftriaxone results in increased expression of ECE1 mRNA
CTD
PMID:29745864
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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Epo
erythropoietin
increases expression
EXP
Ceftriaxone results in increased expression of EPO mRNA
CTD
PMID:29745864
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Ide
insulin degrading enzyme
increases expression
EXP
Ceftriaxone results in increased expression of IDE mRNA
CTD
PMID:29745864
NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
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Il1b
interleukin 1 beta
multiple interactions
EXP
Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]]
CTD
PMID:25053526
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Mme
membrane metallo-endopeptidase
increases expression
EXP
Ceftriaxone results in increased expression of MME mRNA
CTD
PMID:29745864
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Slc1a2
solute carrier family 1 member 2
multiple interactions increases expression
EXP
Ceftriaxone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [JZL195 results in decreased expression of and affects the folding of SLC1A2 protein]; Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein] Ceftriaxone results in increased expression of SLC1A2 protein
CTD
PMID:19625514 PMID:19717140 PMID:28257918 PMID:29045497 PMID:29432698
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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Slc7a11
solute carrier family 7 member 11
multiple interactions
EXP
Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]
CTD
PMID:19717140
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Tnf
tumor necrosis factor
multiple interactions
EXP
Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]]
CTD
PMID:25053526
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression multiple interactions
ISO
Clavulanic Acid results in decreased expression of ABCB11 mRNA Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]
CTD
PMID:34767876
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression
ISO
Clavulanic Acid results in decreased expression of ABCB4 mRNA
CTD
PMID:34767876
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
Clavulanic Acid results in increased expression of ABCC2 mRNA
CTD
PMID:34767876
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcg5
ATP binding cassette subfamily G member 5
decreases expression multiple interactions
ISO
Clavulanic Acid results in decreased expression of ABCG5 mRNA Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; GW 4064 inhibits the reaction [Clavulanic Acid results in decreased expression of ABCG5 mRNA]
CTD
PMID:34767876
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Clavulanic Acid results in increased expression of AKR1B10 mRNA
CTD
PMID:34767876
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
Clavulanic Acid results in decreased expression of CYP27A1 mRNA
CTD
PMID:34767876
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Clavulanic Acid results in decreased expression of CYP7A1 mRNA
CTD
PMID:34767876
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
Clavulanic Acid results in decreased expression of CYP8B1 mRNA
CTD
PMID:34767876
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Ereg
epiregulin
increases expression decreases expression
ISO
Clavulanic Acid results in increased expression of EREG mRNA Clavulanic Acid results in decreased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Clavulanic Acid results in increased expression of FGF19 mRNA
CTD
PMID:34767876
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
G
G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
Clavulanic Acid results in increased expression of G6PD mRNA
CTD
PMID:34767876
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
Clavulanic Acid results in increased expression of GCLC mRNA
CTD
PMID:34767876
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Clavulanic Acid results in increased expression of GCLM mRNA
CTD
PMID:34767876
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gpx2
glutathione peroxidase 2
increases expression
ISO
Clavulanic Acid results in increased expression of GPX2 mRNA
CTD
PMID:34767876
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gsr
glutathione-disulfide reductase
increases expression
ISO
Clavulanic Acid results in increased expression of GSR mRNA
CTD
PMID:34767876
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Il1a
interleukin 1 alpha
increases expression
ISO
Clavulanic Acid results in increased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
increases expression
ISO
Clavulanic Acid results in increased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il24
interleukin 24
increases expression decreases expression
ISO
Clavulanic Acid results in increased expression of IL24 mRNA Clavulanic Acid results in decreased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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Lss
lanosterol synthase
decreases expression
ISO
Clavulanic Acid results in decreased expression of LSS mRNA
CTD
PMID:34767876
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Me1
malic enzyme 1
increases expression
ISO
Clavulanic Acid results in increased expression of ME1 mRNA
CTD
PMID:34767876
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
Clavulanic Acid results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mvk
mevalonate kinase
decreases expression
ISO
Clavulanic Acid results in decreased expression of MVK mRNA
CTD
PMID:34767876
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Clavulanic Acid results in increased expression of NR0B2 mRNA
CTD
PMID:34767876
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Scd
stearoyl-CoA desaturase
decreases expression
ISO
Clavulanic Acid results in decreased expression of SCD mRNA
CTD
PMID:34767876
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Clavulanic Acid results in decreased expression of SLC10A1 mRNA
CTD
PMID:34767876
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
G
Slc51a
solute carrier family 51 subunit alpha
decreases expression multiple interactions
ISO
Clavulanic Acid results in decreased expression of SLC51A mRNA Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of SLC51A mRNA]
CTD
PMID:34767876
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
G
Slc7a11
solute carrier family 7 member 11
decreases expression increases expression
ISO
Clavulanic Acid results in decreased expression of SLC7A11 mRNA Clavulanic Acid results in increased expression of SLC7A11 mRNA
CTD
PMID:32816093 PMID:34767876
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Clavulanic Acid results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
Clavulanic Acid results in decreased expression of SREBF1 mRNA
CTD
PMID:34767876
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Tkt
transketolase
increases expression
ISO
Clavulanic Acid results in increased expression of TKT mRNA
CTD
PMID:34767876
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Tnfaip6
TNF alpha induced protein 6
increases expression
ISO
Clavulanic Acid results in increased expression of TNFAIP6 mRNA
CTD
PMID:32816093
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
G
Txnrd1
thioredoxin reductase 1
increases expression
ISO
Clavulanic Acid results in increased expression of TXNRD1 mRNA
CTD
PMID:34767876
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
G
Il6
interleukin 6
affects expression
EXP
salicylsalicylic acid affects the expression of IL6 protein
CTD
PMID:20876710
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Nos3
nitric oxide synthase 3
multiple interactions
EXP
salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein
CTD
PMID:20876710
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Rela
RELA proto-oncogene, NF-kB subunit
affects expression
EXP
salicylsalicylic acid affects the expression of RELA protein
CTD
PMID:20876710
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Sod2
superoxide dismutase 2
affects expression
EXP
salicylsalicylic acid affects the expression of SOD2 protein
CTD
PMID:20876710
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Vegfa
vascular endothelial growth factor A
affects expression
EXP
salicylsalicylic acid affects the expression of VEGFA protein
CTD
PMID:20876710
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Ozone promotes the reaction [[tazobactam co-treated with Piperacillin] results in increased expression of IL1B mRNA]
CTD
PMID:16369182
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Tnf
tumor necrosis factor
multiple interactions
EXP
Ozone promotes the reaction [[tazobactam co-treated with Piperacillin] results in increased expression of TNF mRNA]
CTD
PMID:16369182
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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