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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.22.* (cysteine endopeptidase) inhibitor
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Accession:CHEBI:76796 term browser browse the term
Definition:An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any cysteine endopeptidase (EC 3.4.22.*).
Synonyms:related_synonym: EC 3.4.22.* inhibitor;   EC 3.4.22.* inhibitors;   cysteine endopeptidase (EC 3.4.22.*) inhibitors;   cysteine endopeptidase inhibitor;   cysteine endopeptidase inhibitors


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acetylleucyl-leucyl-norleucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Apob apolipoprotein B multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Glucosamine results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal results in increased expression of and results in increased secretion of APOB protein CTD PMID:19342510, PMID:19383982 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of BIRC5 protein] CTD PMID:29974605 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO acetylleucyl-leucyl-norleucinal results in increased activity of CASP3 protein
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:15618349, PMID:27481217, PMID:29111403 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO acetylleucyl-leucyl-norleucinal promotes the reaction [Immunologic Factors results in increased expression of CASP7 protein modified form] CTD PMID:29974605 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] CTD PMID:17373649 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [resveratrol results in increased degradation of CCND1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND1 protein] CTD PMID:11895924, PMID:16024653 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein] CTD PMID:16024653 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]; acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein] CTD PMID:20054826 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of CTNNB1 protein] CTD PMID:29974605 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:27481217 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] CTD PMID:17291458 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO acetylleucyl-leucyl-norleucinal promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of JUN protein CTD PMID:15618349 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of MAPK8 protein CTD PMID:15618349 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO
EXP
acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of MYC protein] CTD PMID:29974605 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases degradation
ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased degradation of and results in decreased expression of NFKBIA protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein]
acetylleucyl-leucyl-norleucinal results in decreased degradation of NFKBIA protein
CTD PMID:15930313, PMID:17291458, PMID:18606398 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] CTD PMID:21810436 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO acetylleucyl-leucyl-norleucinal results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma increases methylation
decreases expression
ISO acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoter
acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNA
CTD PMID:15564131 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [SGA 360 results in increased degradation of and results in decreased expression of SREBF1 protein] CTD PMID:31225620 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Ttn titin multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein] CTD PMID:22532871 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] CTD PMID:21444628, PMID:30796972 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein] CTD PMID:21444628 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
aloxistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn7 calpain 7 multiple interactions ISO aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr16:7,435,541...7,472,483
Ensembl chr16:7,435,634...7,471,807
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein] CTD PMID:26853465 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806, PMID:32186374 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D multiple interactions ISO [aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein CTD PMID:32186374 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsl cathepsin L multiple interactions ISO aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein CTD PMID:32186374 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
amentoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:28185818 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] CTD PMID:28185818 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD PMID:28185818 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:28185818 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:28185818 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO amentoflavone results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein CTD PMID:17473463 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:28185818 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein] CTD PMID:28185818 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein] CTD PMID:28185818 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein] CTD PMID:28185818 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO amentoflavone results in decreased expression of NOS2 protein
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:12144868, PMID:28185818 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO amentoflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein
[amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
CTD PMID:12144868 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:28185818 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tyr tyrosinase decreases activity ISO amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO amentoflavone results in decreased activity of UGT1A1 protein CTD PMID:29470958 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO amentoflavone results in decreased activity of UGT1A3 protein CTD PMID:29470958 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 decreases activity ISO amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity
multiple interactions
ISO amentoflavone results in decreased activity of UGT1A6 protein
amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
CTD PMID:29470958, PMID:32421801 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 decreases activity ISO amentoflavone results in decreased activity of UGT1A8 protein CTD PMID:29470958 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO amentoflavone results in decreased activity of UGT1A9 protein CTD PMID:29470958 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases activity ISO amentoflavone results in decreased activity of UGT2B17 protein CTD PMID:29470958 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme decreases expression ISO cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cenpf centromere protein F decreases expression ISO cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 3:125,470,499...125,500,795
Ensembl chr 3:125,470,551...125,500,795
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 3:177,281,365...177,341,550
Ensembl chr 3:177,310,753...177,341,547
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Tp53 tumor protein p53 increases expression
increases activity
ISO cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein
CTD PMID:16120219 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
geldanamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression ISO geldanamycin results in increased expression of ACAP2 mRNA CTD PMID:26705709 NCBI chr11:73,078,966...73,193,496
Ensembl chr11:73,078,982...73,191,132
JBrowse link
G Actr2 actin related protein 2 increases expression ISO geldanamycin results in increased expression of ACTR2 mRNA CTD PMID:26705709 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
JBrowse link
G Aff3 AF4/FMR2 family, member 3 increases expression ISO geldanamycin results in increased expression of AFF3 mRNA CTD PMID:26705709 NCBI chr 9:44,837,979...45,291,964
Ensembl chr 9:44,839,960...45,292,047
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO geldanamycin results in increased expression of AFF4 mRNA CTD PMID:26705709 NCBI chr10:38,692,167...38,773,021
Ensembl chr10:38,692,211...38,773,021
JBrowse link
G Agfg1 ArfGAP with FG repeats 1 increases expression ISO geldanamycin results in increased expression of AGFG1 mRNA CTD PMID:26705709 NCBI chr 9:88,607,508...88,663,486
Ensembl chr 9:88,607,508...88,662,224
JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
decreases expression
increases degradation
multiple interactions
ISO geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
CTD PMID:9664232, PMID:12237327, PMID:12606767, PMID:16226227, PMID:20057149, PMID:27105554 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein
CTD PMID:15781649, PMID:17293044, PMID:19167484, PMID:24211270, PMID:24450340 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt3 AKT serine/threonine kinase 3 increases expression ISO geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Amotl1 angiomotin-like 1 increases expression ISO geldanamycin results in increased expression of AMOTL1 mRNA CTD PMID:26705709 NCBI chr 8:13,037,265...13,157,701
Ensembl chr 8:13,042,641...13,109,487
JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO geldanamycin results in increased expression of ANGPT1 mRNA CTD PMID:26705709 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO geldanamycin results in decreased expression of ANGPTL1 mRNA CTD PMID:26705709 NCBI chr13:74,456,487...74,463,031
Ensembl chr13:74,410,010...74,474,681
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO geldanamycin results in increased expression of ANKRD1 mRNA CTD PMID:26705709 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ap5m1 adaptor related protein complex 5 subunit mu 1 increases expression ISO geldanamycin results in increased expression of AP5M1 mRNA CTD PMID:26705709 NCBI chr15:25,933,483...25,955,745
Ensembl chr15:25,933,483...25,955,745
JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 increases expression ISO geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 NCBI chr 7:26,256,179...26,306,128
Ensembl chr 7:26,256,459...26,306,126
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO geldanamycin results in increased expression of ARFIP1 mRNA CTD PMID:26705709 NCBI chr 2:183,503,250...183,582,798
Ensembl chr 2:183,504,330...183,582,553
JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO geldanamycin results in increased expression of ASPM mRNA CTD PMID:26705709 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO geldanamycin results in increased expression of ATP11B mRNA CTD PMID:26705709 NCBI chr 2:122,337,757...122,445,090
Ensembl chr 2:122,368,265...122,444,878
JBrowse link
G Atp11c ATPase phospholipid transporting 11C increases expression ISO geldanamycin results in increased expression of ATP11C mRNA CTD PMID:26705709 NCBI chr  X:143,340,712...143,525,588
Ensembl chr  X:143,346,252...143,453,612
JBrowse link
G Atp13a3 ATPase 13A3 increases expression ISO geldanamycin results in increased expression of ATP13A3 mRNA CTD PMID:26705709 NCBI chr11:73,936,750...73,963,852
Ensembl chr11:73,936,750...73,963,852
JBrowse link
G Atp13a5 ATPase 13A5 increases expression ISO geldanamycin results in increased expression of ATP13A5 mRNA CTD PMID:26705709 NCBI chr11:74,984,538...75,124,249
Ensembl chr11:74,984,613...75,124,249
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO geldanamycin results in increased expression of ATRX mRNA CTD PMID:26705709 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Atxn7l3b ataxin 7-like 3B increases expression ISO geldanamycin results in increased expression of ATXN7L3B mRNA CTD PMID:26705709 NCBI chr 7:55,600,879...55,604,403
Ensembl chr 7:55,600,889...55,604,403
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein
geldanamycin results in decreased expression of BCL2 protein
CTD PMID:15781649, PMID:28673683 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
multiple interactions
ISO BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein
CTD PMID:15781649 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO geldanamycin results in increased expression of BCOR mRNA CTD PMID:26705709 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099
JBrowse link
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression ISO geldanamycin results in increased expression of BDP1 mRNA CTD PMID:26705709 NCBI chr 2:30,248,458...30,340,211
Ensembl chr 2:30,250,633...30,340,208
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein CTD PMID:15781649 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 increases expression ISO geldanamycin results in increased expression of BOD1L1 mRNA CTD PMID:26705709 NCBI chr14:73,738,137...73,792,935
Ensembl chr14:73,738,137...73,791,656
JBrowse link
G Cab39 calcium binding protein 39 increases expression ISO geldanamycin results in increased expression of CAB39 mRNA CTD PMID:26705709 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Cald1 caldesmon 1 increases expression ISO geldanamycin results in increased expression of CALD1 mRNA CTD PMID:26705709 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase increases expression ISO geldanamycin results in increased expression of CASK mRNA CTD PMID:26705709 NCBI chr  X:9,815,652...10,156,155
Ensembl chr  X:9,815,652...10,156,155
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] CTD PMID:12115584, PMID:12530016, PMID:14576064, PMID:24998639 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein] CTD PMID:24998639 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] CTD PMID:16311509 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO geldanamycin results in increased expression of CBL mRNA CTD PMID:26705709 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccdc186 coiled-coil domain containing 186 increases expression ISO geldanamycin results in increased expression of CCDC186 mRNA CTD PMID:26705709 NCBI chr 1:277,603,601...277,635,379
Ensembl chr 1:277,606,995...277,629,196
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein
CTD PMID:15781649, PMID:17959518, PMID:24211270 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO geldanamycin results in increased expression of CCND2 mRNA CTD PMID:26705709 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne2 cyclin E2 increases expression ISO geldanamycin results in increased expression of CCNE2 mRNA CTD PMID:26705709 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnk cyclin K increases expression ISO geldanamycin results in increased expression of CCNK mRNA CTD PMID:26705709 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
JBrowse link
G Cdc27 cell division cycle 27 increases expression ISO geldanamycin results in increased expression of CDC27 mRNA CTD PMID:26705709 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] CTD PMID:17223712 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO geldanamycin results in increased expression of CDCA2 mRNA CTD PMID:26705709 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh4 cadherin 4 increases expression ISO geldanamycin results in increased expression of CDH4 mRNA CTD PMID:26705709 NCBI chr 3:175,220,520...175,283,144
Ensembl chr 3:175,144,495...175,279,761
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO geldanamycin results in increased expression of CDK13 mRNA CTD PMID:26705709 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk14 cyclin-dependent kinase 14 increases expression ISO geldanamycin results in increased expression of CDK14 mRNA CTD PMID:26705709 NCBI chr 4:25,825,567...26,419,443
Ensembl chr 4:25,825,567...26,419,127
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO geldanamycin results in increased expression of CDK6 mRNA CTD PMID:26705709 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenpj centromere protein J increases expression ISO geldanamycin results in increased expression of CENPJ mRNA CTD PMID:26705709 NCBI chr15:36,745,672...36,809,228
Ensembl chr15:36,746,088...36,798,814
JBrowse link
G Cep89 centrosomal protein 89 increases expression ISO geldanamycin results in increased expression of CEP89 mRNA CTD PMID:26705709 NCBI chr 1:91,663,723...91,705,979
Ensembl chr 1:91,663,736...91,706,094
JBrowse link
G Cep95 centrosomal protein 95 increases expression ISO geldanamycin results in increased expression of CEP95 mRNA CTD PMID:26705709 NCBI chr10:94,988,362...95,017,774
Ensembl chr10:94,988,362...95,016,344
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO geldanamycin results in increased expression of CERS6 mRNA CTD PMID:26705709 NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases degradation ISO geldanamycin results in increased degradation of CHUK protein CTD PMID:15930313 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression ISO geldanamycin results in increased expression of CLIP1 mRNA CTD PMID:26705709 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652
JBrowse link
G Clk4 CDC-like kinase 4 increases expression ISO geldanamycin results in increased expression of CLK4 mRNA CTD PMID:26705709 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL12A1 mRNA CTD PMID:26705709 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Col25a1 collagen type XXV alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL25A1 mRNA CTD PMID:26705709 NCBI chr 2:235,515,364...235,705,448
Ensembl chr 2:235,596,123...235,715,057
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL8A1 mRNA CTD PMID:26705709 NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
JBrowse link
G Cpne3 copine 3 increases expression ISO geldanamycin results in increased expression of CPNE3 mRNA CTD PMID:26705709 NCBI chr 5:33,525,307...33,574,610
Ensembl chr 5:33,528,154...33,574,596
JBrowse link
G Crcp CGRP receptor component increases expression ISO geldanamycin results in increased expression of CRCP mRNA CTD PMID:26705709 NCBI chr12:30,125,237...30,160,857
Ensembl chr12:30,125,168...30,180,115
JBrowse link
G Csk C-terminal Src kinase multiple interactions
decreases activity
ISO geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein
CTD PMID:9664232 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO geldanamycin results in increased expression of CSNK2A1 mRNA CTD PMID:26705709 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Ctdspl2 CTD small phosphatase like 2 increases expression ISO geldanamycin results in increased expression of CTDSPL2 mRNA CTD PMID:26705709 NCBI chr 3:113,906,803...113,957,289
Ensembl chr 3:113,918,629...113,960,101
JBrowse link
G Ctnna1 catenin alpha 1 increases expression ISO geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] CTD PMID:17024233 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cul5 cullin 5 increases expression ISO geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 NCBI chr 8:58,199,992...58,255,149
Ensembl chr 8:58,202,821...58,253,688
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO geldanamycin results in increased expression of CYP17A1 mRNA CTD PMID:15711029 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:12237327, PMID:20057149 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 increases expression ISO geldanamycin results in increased expression of DDR2 mRNA CTD PMID:26705709 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO geldanamycin results in increased expression of DDX17 mRNA CTD PMID:26705709 NCBI chr 7:120,761,843...120,765,012
Ensembl chr 7:120,761,826...120,780,641
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression ISO geldanamycin results in increased expression of DDX3X mRNA CTD PMID:26705709 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx42 DEAD-box helicase 42 increases expression ISO geldanamycin results in increased expression of DDX42 mRNA CTD PMID:26705709 NCBI chr10:94,407,094...94,439,052
Ensembl chr10:94,407,559...94,439,052
JBrowse link
G Ddx6 DEAD-box helicase 6 increases expression ISO geldanamycin results in increased expression of DDX6 mRNA CTD PMID:26705709 NCBI chr 8:48,924,768...48,961,394
Ensembl chr 8:48,925,604...48,958,026
JBrowse link
G Dhx9 DExH-box helicase 9 increases expression ISO geldanamycin results in increased expression of DHX9 mRNA CTD PMID:26705709 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dip2a disco-interacting protein 2 homolog A increases expression ISO geldanamycin results in increased expression of DIP2A mRNA CTD PMID:26705709 NCBI chr20:13,044,056...13,127,971
Ensembl chr20:13,044,104...13,127,487
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression ISO geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dmd dystrophin increases expression ISO geldanamycin results in increased expression of DMD mRNA CTD PMID:26705709 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 increases expression ISO geldanamycin results in increased expression of DNAJC13 mRNA CTD PMID:26705709 NCBI chr 8:112,697,907...112,830,445
Ensembl chr 8:112,698,348...112,807,598
JBrowse link
G Dst dystonin increases expression ISO geldanamycin results in increased expression of DST mRNA CTD PMID:26705709 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO geldanamycin results in increased expression of E2F3 mRNA CTD PMID:26705709 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 increases expression ISO geldanamycin results in increased expression of EDIL3 mRNA CTD PMID:26705709 NCBI chr 2:17,616,116...18,128,514
Ensembl chr 2:17,616,401...18,128,512
JBrowse link
G Edn1 endothelin 1 increases expression ISO geldanamycin results in increased expression of EDN1 mRNA CTD PMID:26705709 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eea1 early endosome antigen 1 increases expression ISO geldanamycin results in increased expression of EEA1 mRNA CTD PMID:26705709 NCBI chr 7:37,101,415...37,186,534
Ensembl chr 7:37,018,459...37,186,732
JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431, PMID:9664232 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein
CTD PMID:9605431, PMID:9664232, PMID:20007406 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO geldanamycin results in increased expression of EHBP1 mRNA CTD PMID:26705709 NCBI chr14:106,871,426...107,160,224
Ensembl chr14:106,871,430...107,160,334
JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 increases expression ISO geldanamycin results in increased expression of EHMT1 mRNA CTD PMID:26705709 NCBI chr 3:1,966,974...2,123,858
Ensembl chr 3:1,960,957...2,123,820
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO geldanamycin results in increased expression of ELL2 mRNA CTD PMID:26705709 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 increases expression ISO geldanamycin results in increased expression of EPB41L5 mRNA CTD PMID:26705709 NCBI chr13:35,622,472...35,673,449
Ensembl chr13:35,580,098...35,668,968
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression ISO geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases degradation
multiple interactions
decreases expression
ISO geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein
CTD PMID:8617772, PMID:11071886, PMID:17959518, PMID:18655187, PMID:24450340 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ercc6l2 ERCC excision repair 6 like 2 increases expression ISO geldanamycin results in increased expression of ERCC6L2 mRNA CTD PMID:26705709 NCBI chr17:1,325,654...1,421,732
Ensembl chr17:1,305,016...1,421,685
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression ISO geldanamycin results in increased expression of ESCO1 mRNA CTD PMID:26705709 NCBI chr18:1,789,796...1,857,271
Ensembl chr18:1,789,900...1,828,606
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO geldanamycin results in increased expression of ESCO2 mRNA CTD PMID:26705709 NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
decreases stability
increases degradation
ISO geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein
CTD PMID:11448926, PMID:16037132, PMID:24211270 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO geldanamycin results in increased expression of ETS1 mRNA CTD PMID:26705709 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO geldanamycin results in increased expression of EVI5 mRNA CTD PMID:26705709 NCBI chr14:2,892,738...3,038,237
Ensembl chr14:2,892,753...3,038,237
JBrowse link
G Fam126a family with sequence similarity 126, member A increases expression ISO geldanamycin results in increased expression of FAM126A mRNA CTD PMID:26705709 NCBI chr 4:7,661,710...7,770,179
Ensembl chr 4:7,661,558...7,770,232
JBrowse link
G Fam172a family with sequence similarity 172, member A increases expression ISO geldanamycin results in increased expression of FAM172A mRNA CTD PMID:26705709 NCBI chr 2:4,942,795...5,547,744
Ensembl chr 2:4,942,775...5,545,144
JBrowse link
G Fancb FA complementation group B increases expression ISO geldanamycin results in increased expression of FANCB mRNA CTD PMID:26705709 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711
JBrowse link
G Fancm FA complementation group M increases expression ISO geldanamycin results in increased expression of FANCM mRNA CTD PMID:26705709 NCBI chr 6:86,823,195...86,877,067
Ensembl chr 6:86,823,684...86,876,633
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO geldanamycin results in increased expression of FBN1 mRNA CTD PMID:26705709 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] CTD PMID:14656992 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 increases expression ISO geldanamycin results in increased expression of FN1 mRNA CTD PMID:26705709 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fryl FRY like transcription coactivator increases expression ISO geldanamycin results in increased expression of FRYL mRNA CTD PMID:26705709 NCBI chr14:37,551,109...37,757,511
Ensembl chr14:37,551,940...37,756,149
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO geldanamycin results in increased expression of G3BP1 mRNA CTD PMID:26705709 NCBI chr10:40,812,858...40,846,252
Ensembl chr10:40,812,858...40,846,252
JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression ISO geldanamycin results in increased expression of GALNT5 mRNA CTD PMID:26705709 NCBI chr 3:44,025,964...44,072,073
Ensembl chr 3:44,025,300...44,074,678
JBrowse link
G Gls glutaminase increases expression ISO geldanamycin results in increased expression of GLS mRNA CTD PMID:26705709 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gng12 G protein subunit gamma 12 increases expression ISO geldanamycin results in increased expression of GNG12 mRNA CTD PMID:26705709 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102
JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO geldanamycin results in increased expression of GOLIM4 mRNA CTD PMID:26705709 NCBI chr 2:174,321,303...174,413,847
Ensembl chr 2:174,322,673...174,413,236
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression ISO geldanamycin results in increased expression of GRIA3 mRNA CTD PMID:26705709 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 increases expression ISO geldanamycin results in increased expression of GTF2A1 mRNA CTD PMID:26705709 NCBI chr 6:115,321,110...115,352,659
Ensembl chr 6:115,320,467...115,352,681
JBrowse link
G H4f3 H1.3 linker histone, cluster member increases expression ISO geldanamycin results in increased expression of H1-3 mRNA CTD PMID:26705709 NCBI chr17:43,797,711...43,798,450
Ensembl chr17:43,797,721...43,798,383
JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 increases expression ISO geldanamycin results in increased expression of HACD2 mRNA CTD PMID:26705709 NCBI chr11:68,893,684...68,985,635
Ensembl chr11:68,894,445...68,989,988
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 increases expression ISO geldanamycin results in increased expression of HCN1 mRNA CTD PMID:26705709 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Heatr1 HEAT repeat containing 1 increases expression ISO geldanamycin results in increased expression of HEATR1 mRNA CTD PMID:26705709 NCBI chr17:66,446,135...66,488,303
Ensembl chr17:66,446,162...66,619,250
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 increases expression ISO geldanamycin results in increased expression of HECTD1 mRNA CTD PMID:26705709 NCBI chr 6:72,509,658...72,596,285
Ensembl chr 6:72,510,255...72,596,446
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein
CTD PMID:11980636, PMID:12811834, PMID:14726529, PMID:15319539, PMID:16432534 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein] CTD PMID:25645596 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] CTD PMID:15680906 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574, PMID:25645596 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 affects binding
multiple interactions
EXP
ISO
geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]
CTD PMID:12775586, PMID:17223712, PMID:18655187, PMID:21749116 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding
increases expression
EXP
ISO
geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA
CTD PMID:21749116, PMID:26705709 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 affects binding
multiple interactions
ISO geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]
CTD PMID:8617772 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP
ISO
geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins
CTD PMID:11448926, PMID:19723345, PMID:25477506 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509, PMID:26705709 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
affects expression
ISO Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein
CTD PMID:14576064, PMID:15141013 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO geldanamycin results in increased expression of HSPD1 mRNA CTD PMID:26705709 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htt huntingtin multiple interactions ISO geldanamycin inhibits the reaction [HTT protein binds to HTT protein] CTD PMID:11406612 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Ice2 interactor of little elongation complex ELL subunit 2 increases expression ISO geldanamycin results in increased expression of ICE2 mRNA CTD PMID:26705709 NCBI chr 8:75,625,147...75,666,959
Ensembl chr 8:75,625,174...75,666,866
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]
CTD PMID:12571865, PMID:15808840 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 multiple interactions ISO IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il6 interleukin 6 multiple interactions ISO geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] CTD PMID:12571865 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer increases expression ISO geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO geldanamycin results in increased expression of INHBA mRNA CTD PMID:26705709 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A increases expression ISO geldanamycin results in increased expression of INPP5A mRNA CTD PMID:26705709 NCBI chr 1:211,732,163...211,920,844
Ensembl chr 1:211,732,713...211,921,099
JBrowse link
G Ipo8 importin 8 increases expression ISO geldanamycin results in increased expression of IPO8 mRNA CTD PMID:26705709 NCBI chr 4:183,228,688...183,295,253 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO geldanamycin results in increased expression of IQGAP1 mRNA CTD PMID:26705709 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression ISO geldanamycin results in increased expression of ITGA1 mRNA CTD PMID:26705709 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression ISO geldanamycin results in increased expression of ITGB3 mRNA CTD PMID:26705709 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itprid2 ITPR interacting domain containing 2 increases expression ISO geldanamycin results in increased expression of ITPRID2 mRNA CTD PMID:26705709 NCBI chr 3:66,593,767...66,631,143
Ensembl chr 3:66,593,934...66,631,723
JBrowse link
G Jmjd1c jumonji domain containing 1C increases expression ISO geldanamycin results in increased expression of JMJD1C mRNA CTD PMID:26705709 NCBI chr20:22,751,743...22,914,080
Ensembl chr20:22,751,743...22,882,672
JBrowse link
G Kat6a lysine acetyltransferase 6A increases expression ISO geldanamycin results in increased expression of KAT6A mRNA CTD PMID:26705709 NCBI chr16:73,942,669...74,020,750
Ensembl chr16:73,943,455...74,023,005
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 increases expression ISO geldanamycin results in increased expression of KBTBD2 mRNA CTD PMID:26705709 NCBI chr 4:87,088,759...87,111,576
Ensembl chr 4:87,088,759...87,111,025
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects localization
decreases activity
increases degradation
multiple interactions
decreases expression
ISO geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kdm6a lysine demethylase 6A increases expression ISO geldanamycin results in increased expression of KDM6A mRNA CTD PMID:26705709 NCBI chr  X:4,805,493...4,945,788
Ensembl chr  X:4,806,277...4,945,944
JBrowse link
G Kirrel1 kirre like nephrin family adhesion molecule 1 increases expression ISO geldanamycin results in increased expression of KIRREL1 mRNA CTD PMID:26705709 NCBI chr 2:186,420,743...186,515,209
Ensembl chr 2:186,420,795...186,515,135
JBrowse link
G Klf12 Kruppel-like factor 12 increases expression ISO geldanamycin results in increased expression of KLF12 mRNA CTD PMID:26705709 NCBI chr15:84,316,986...84,748,549
Ensembl chr15:84,324,470...84,748,525
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO geldanamycin results in increased expression of KLHL24 mRNA CTD PMID:26705709 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression ISO geldanamycin results in increased expression of KMT2A mRNA CTD PMID:26705709 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Lama4 laminin subunit alpha 4 increases expression ISO geldanamycin results in increased expression of LAMA4 mRNA CTD PMID:26705709 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Larp1b La ribonucleoprotein 1B increases expression ISO geldanamycin results in increased expression of LARP1B mRNA CTD PMID:26705709 NCBI chr 2:127,845,034...127,876,793
Ensembl chr 2:127,845,034...127,876,793
JBrowse link
G Larp4 La ribonucleoprotein 4 increases expression ISO geldanamycin results in increased expression of LARP4 mRNA CTD PMID:26705709 NCBI chr 7:141,630,229...141,676,242 JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression ISO geldanamycin results in increased expression of LARS1 mRNA CTD PMID:26705709 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO geldanamycin results in increased expression of LIMA1 mRNA CTD PMID:26705709 NCBI chr 7:141,428,113...141,528,447
Ensembl chr 7:141,428,063...141,528,397
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component increases expression ISO geldanamycin results in increased expression of LIN7A mRNA CTD PMID:26705709 NCBI chr 7:49,429,613...49,627,835
Ensembl chr 7:49,385,705...49,656,856
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO geldanamycin results in increased expression of LMAN1 mRNA CTD PMID:26705709 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO geldanamycin results in increased expression of LMO7 mRNA CTD PMID:26705709 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G LOC100911204 protein CASC5-like increases expression ISO geldanamycin results in increased expression of KNL1 mRNA CTD PMID:26705709 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma increases expression ISO geldanamycin results in increased expression of LPP mRNA CTD PMID:26705709 NCBI chr11:79,192,603...79,827,858
Ensembl chr11:79,205,730...79,703,736
JBrowse link
G Lrrc58 leucine rich repeat containing 58 increases expression ISO geldanamycin results in increased expression of LRRC58 mRNA CTD PMID:26705709 NCBI chr11:65,747,235...65,759,558
Ensembl chr11:65,747,036...65,759,581
JBrowse link
G Lsm14b LSM family member 14B increases expression ISO geldanamycin results in increased expression of LSM14B mRNA CTD PMID:26705709 NCBI chr 3:175,408,433...175,419,180
Ensembl chr 3:175,408,629...175,417,610
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 increases expression ISO geldanamycin results in increased expression of MAN1A2 mRNA CTD PMID:26705709 NCBI chr 2:202,891,537...203,043,847
Ensembl chr 2:202,891,537...203,043,847
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO geldanamycin results in increased expression of MAP1B mRNA CTD PMID:26705709 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein
CTD PMID:8816498, PMID:19167484 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation ISO geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO geldanamycin results in increased expression of MAP3K1 mRNA CTD PMID:26705709 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP3K5 mRNA CTD PMID:26705709 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP4K5 mRNA CTD PMID:26705709 NCBI chr 6:92,136,242...92,229,578
Ensembl chr 6:92,136,992...92,229,260
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:8816498, PMID:15888667, PMID:17293044, PMID:19167484, PMID:30166341 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:8816498, PMID:15888667, PMID:17293044, PMID:19167484 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression ISO geldanamycin results in increased expression of MAPKAPK2 mRNA CTD PMID:26705709 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Matr3 matrin 3 increases expression ISO geldanamycin results in increased expression of MATR3 mRNA CTD PMID:26705709 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 increases expression ISO geldanamycin results in increased expression of MBNL1 mRNA CTD PMID:26705709 NCBI chr 2:150,698,248...150,867,791
Ensembl chr 2:150,756,185...150,869,690
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 increases expression ISO geldanamycin results in increased expression of MBNL2 mRNA CTD PMID:26705709 NCBI chr15:105,640,097...105,797,933
Ensembl chr15:105,640,097...105,797,932
JBrowse link
G Mbtd1 mbt domain containing 1 increases expression ISO geldanamycin results in increased expression of MBTD1 mRNA CTD PMID:26705709 NCBI chr10:81,588,233...81,645,532
Ensembl chr10:81,592,114...81,642,663
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO geldanamycin results in increased expression of MCAM mRNA CTD PMID:26705709 NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO geldanamycin results in increased expression of MCM4 mRNA CTD PMID:26705709 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mdfic MyoD family inhibitor domain containing increases expression ISO geldanamycin results in increased expression of MDFIC mRNA CTD PMID:26705709 NCBI chr 4:42,202,546...42,282,499
Ensembl chr 4:42,202,838...42,282,496
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Med13 mediator complex subunit 13 increases expression ISO geldanamycin results in increased expression of MED13 mRNA CTD PMID:26705709 NCBI chr10:73,702,327...73,787,084
Ensembl chr10:73,702,327...73,787,083
JBrowse link
G Med7 mediator complex subunit 7 increases expression ISO geldanamycin results in increased expression of MED7 mRNA CTD PMID:26705709 NCBI chr10:31,532,190...31,536,405
Ensembl chr10:31,532,250...31,536,405
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO geldanamycin results in increased expression of MET mRNA CTD PMID:26705709 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mettl16 methyltransferase like 16 increases expression ISO geldanamycin results in increased expression of METTL16 mRNA CTD PMID:26705709 NCBI chr10:61,626,595...61,682,947
Ensembl chr10:61,626,597...61,672,136
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO geldanamycin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mier1 MIER1 transcriptional regulator increases expression ISO geldanamycin results in increased expression of MIER1 mRNA CTD PMID:26705709 NCBI chr 5:122,642,065...122,693,642
Ensembl chr 5:122,641,885...122,693,635
JBrowse link
G Mir21 microRNA 21 increases expression ISO geldanamycin results in increased expression of MIR21 mRNA CTD PMID:26705709 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mis18bp1 MIS18 binding protein 1 increases expression ISO geldanamycin results in increased expression of MIS18BP1 mRNA CTD PMID:26705709 NCBI chr 6:86,879,106...86,925,209
Ensembl chr 6:86,879,719...86,924,146
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA
CTD PMID:12724357, PMID:26705709 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO geldanamycin results in increased expression of MMP16 mRNA CTD PMID:26705709 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 increases expression ISO geldanamycin results in increased expression of ND6 mRNA CTD PMID:26705709 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Myo5a myosin VA increases expression ISO geldanamycin results in increased expression of MYO5A mRNA CTD PMID:26705709 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617
JBrowse link
G Myocd myocardin increases expression ISO geldanamycin results in increased expression of MYOCD mRNA CTD PMID:26705709 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Mzt1 mitotic spindle organizing protein 1 increases expression ISO geldanamycin results in increased expression of MZT1 mRNA CTD PMID:26705709 NCBI chr15:83,429,437...83,442,118
Ensembl chr15:83,431,178...83,442,008
JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression ISO geldanamycin results in increased expression of NASP mRNA CTD PMID:26705709 NCBI chr 5:135,446,485...135,472,113
Ensembl chr 5:135,446,962...135,472,116
JBrowse link
G Nbas NBAS subunit of NRZ tethering complex increases expression ISO geldanamycin results in increased expression of NBAS mRNA CTD PMID:26705709 NCBI chr 6:38,474,773...38,777,146
Ensembl chr 6:38,474,804...38,777,806
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO geldanamycin results in increased expression of NCOA2 mRNA CTD PMID:26705709 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO geldanamycin results in increased expression of NEDD9 mRNA CTD PMID:26705709 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nes nestin increases expression ISO geldanamycin results in increased expression of NES mRNA CTD PMID:26705709 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nf1 neurofibromin 1 increases expression ISO geldanamycin results in increased expression of NF1 mRNA CTD PMID:26705709 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nf2 neurofibromin 2 increases expression ISO geldanamycin results in increased expression of NF2 mRNA CTD PMID:26705709 NCBI chr14:84,996,905...85,088,547
Ensembl chr14:84,996,905...85,088,523
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO geldanamycin results in increased expression of NFAT5 mRNA CTD PMID:26705709 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression ISO geldanamycin results in increased expression of NIPBL mRNA CTD PMID:26705709 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Nktr natural killer cell triggering receptor increases expression ISO geldanamycin results in increased expression of NKTR mRNA CTD PMID:26705709 NCBI chr 8:130,357,464...130,395,425
Ensembl chr 8:130,366,775...130,393,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313, PMID:15583003 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npr3 natriuretic peptide receptor 3 increases expression ISO geldanamycin results in increased expression of NPR3 mRNA CTD PMID:26705709 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of geldanamycin CTD PMID:16825487 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression ISO geldanamycin results in increased expression of NR2C2 mRNA CTD PMID:26705709 NCBI chr 4:124,005,287...124,030,349
Ensembl chr 4:124,005,280...124,030,349
JBrowse link
G Nrk Nik related kinase increases expression ISO geldanamycin results in increased expression of NRK mRNA CTD PMID:26705709 NCBI chr  X:109,940,439...110,036,361
NCBI chr  X:110,065,199...110,089,124
Ensembl chr  X:109,940,350...110,033,085
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO geldanamycin results in increased expression of OSBPL8 mRNA CTD PMID:26705709 NCBI chr 7:53,878,906...54,030,110
Ensembl chr 7:53,878,610...54,027,892
JBrowse link
G Otud4 OTU deubiquitinase 4 increases expression ISO geldanamycin results in increased expression of OTUD4 mRNA CTD PMID:26705709 NCBI chr19:31,895,753...31,942,509
Ensembl chr19:31,899,087...31,942,180
JBrowse link
G Oxtr oxytocin receptor increases expression ISO geldanamycin results in increased expression of OXTR mRNA CTD PMID:26705709 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Pappa1 pappalysin 1 increases expression ISO geldanamycin results in increased expression of PAPPA mRNA CTD PMID:26705709 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases degradation
ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509, PMID:17293044 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcbp2 poly(rC) binding protein 2 increases expression ISO geldanamycin results in increased expression of PCBP2 mRNA CTD PMID:26705709 NCBI chr 7:144,077,901...144,103,723
Ensembl chr 7:144,078,496...144,101,893
JBrowse link
G Pcm1 pericentriolar material 1 increases expression ISO geldanamycin results in increased expression of PCM1 mRNA CTD PMID:26705709 NCBI chr16:54,040,721...54,137,675
Ensembl chr16:54,040,721...54,137,660
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO geldanamycin results in increased expression of PDE4DIP mRNA CTD PMID:26705709 NCBI chr 2:199,867,965...200,066,034
Ensembl chr 2:199,867,972...200,003,443
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO geldanamycin results in increased expression of PDGFA mRNA CTD PMID:26705709 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO geldanamycin results in increased expression of PEG10 mRNA CTD PMID:26705709 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pgr progesterone receptor decreases expression ISO geldanamycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phactr2 phosphatase and actin regulator 2 increases expression ISO geldanamycin results in increased expression of PHACTR2 mRNA CTD PMID:26705709 NCBI chr 1:7,352,050...7,633,991
Ensembl chr 1:7,355,154...7,480,825
JBrowse link
G Phldb2 pleckstrin homology-like domain, family B, member 2 increases expression ISO geldanamycin results in increased expression of PHLDB2 mRNA CTD PMID:26705709 NCBI chr11:60,042,879...60,051,229
Ensembl chr11:57,265,732...57,481,589
JBrowse link
G Phtf2 putative homeodomain transcription factor 2 increases expression ISO geldanamycin results in increased expression of PHTF2 mRNA CTD PMID:26705709 NCBI chr 4:10,823,191...10,938,273
Ensembl chr 4:10,823,281...10,938,318
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO geldanamycin results in increased expression of PIK3CA mRNA CTD PMID:26705709 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA CTD PMID:12724357 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plppr4 phospholipid phosphatase related 4 increases expression ISO geldanamycin results in increased expression of PLPPR4 mRNA CTD PMID:26705709 NCBI chr 2:220,298,239...220,341,863
Ensembl chr 2:220,298,245...220,341,866
JBrowse link
G Plxna2 plexin A2 increases expression ISO geldanamycin results in increased expression of PLXNA2 mRNA CTD PMID:26705709 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Polr2b RNA polymerase II subunit B decreases expression ISO geldanamycin results in decreased expression of POLR2B mRNA CTD PMID:30166341 NCBI chr14:33,070,104...33,107,792
Ensembl chr14:33,070,078...33,107,776
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K increases expression ISO geldanamycin results in increased expression of PPM1K mRNA CTD PMID:26705709 NCBI chr 4:88,694,395...88,721,374
Ensembl chr 4:88,694,583...88,718,533
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO geldanamycin results in increased expression of PRKG1 mRNA CTD PMID:26705709 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prmt2 protein arginine methyltransferase 2 increases expression ISO geldanamycin results in increased expression of PRMT2 mRNA CTD PMID:26705709 NCBI chr20:13,154,513...13,212,613
Ensembl chr20:13,156,241...13,212,606
JBrowse link
G Prpf6 pre-mRNA processing factor 6 increases expression ISO geldanamycin results in increased expression of PRPF6 mRNA CTD PMID:26705709 NCBI chr 3:177,098,137...177,162,937
Ensembl chr 3:177,098,073...177,162,916
JBrowse link
G Prr14l proline rich 14-like increases expression ISO geldanamycin results in increased expression of PRR14L mRNA CTD PMID:26705709 NCBI chr14:83,226,552...83,293,823
Ensembl chr14:83,226,601...83,293,822
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO geldanamycin results in increased expression of PRRC2C mRNA CTD PMID:26705709 NCBI chr13:80,544,789...80,614,925 JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO geldanamycin results in increased expression of PSME4 mRNA CTD PMID:26705709 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 increases expression ISO geldanamycin results in increased expression of PTAR1 mRNA CTD PMID:26705709 NCBI chr 1:241,501,679...241,557,651
Ensembl chr 1:241,501,679...241,557,651
JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 increases expression ISO geldanamycin results in increased expression of PTBP3 mRNA CTD PMID:26705709 NCBI chr 5:76,670,074...76,756,196
Ensembl chr 5:76,673,990...76,756,147
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO geldanamycin results in decreased expression of PTGS1 mRNA CTD PMID:26705709 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:11133817 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptk2 protein tyrosine kinase 2 increases degradation
decreases phosphorylation
ISO geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein
CTD PMID:9973544, PMID:12811834 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases expression ISO geldanamycin results in increased expression of PTPN11 mRNA CTD PMID:26705709 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 increases expression ISO geldanamycin results in increased expression of PTPN12 mRNA CTD PMID:26705709 NCBI chr 4:10,631,129...10,702,390
Ensembl chr 4:10,631,073...10,702,386
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO geldanamycin results in increased expression of PTPRA mRNA CTD PMID:26705709 NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO geldanamycin results in increased expression of PTPRD mRNA CTD PMID:26705709 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
JBrowse link
G Pygo1 pygopus family PHD finger 1 increases expression ISO geldanamycin results in increased expression of PYGO1 mRNA CTD PMID:26705709 NCBI chr 8:79,607,013...79,625,188
Ensembl chr 8:79,606,789...79,627,166
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO geldanamycin results in increased expression of RAB3B mRNA CTD PMID:26705709 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
JBrowse link
G Rabep1 rabaptin, RAB GTPase binding effector protein 1 increases expression ISO geldanamycin results in increased expression of RABEP1 mRNA CTD PMID:26705709 NCBI chr10:57,462,272...57,579,901
Ensembl chr10:57,462,447...57,579,898
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
decreases expression
multiple interactions
ISO geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein
CTD PMID:8816498, PMID:19167484, PMID:24450340 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of RAPGEF2 mRNA CTD PMID:26705709 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Rassf8 Ras association domain family member 8 increases expression ISO geldanamycin results in increased expression of RASSF8 mRNA CTD PMID:26705709 NCBI chr 4:180,059,020...180,135,924
Ensembl chr 4:180,062,799...180,135,966
JBrowse link
G Rbak RB-associated KRAB zinc finger increases expression ISO geldanamycin results in increased expression of RBAK mRNA CTD PMID:26705709 NCBI chr12:13,428,648...13,442,279
Ensembl chr12:13,428,685...13,442,286
JBrowse link
G Rbm26 RNA binding motif protein 26 increases expression ISO geldanamycin results in increased expression of RBM26 mRNA CTD PMID:26705709 NCBI chr15:89,262,683...89,339,323
Ensembl chr15:89,266,710...89,339,323
JBrowse link
G Rbms3 RNA binding motif, single stranded interacting protein 3 increases expression ISO geldanamycin results in increased expression of RBMS3 mRNA CTD PMID:26705709 NCBI chr 8:124,833,804...125,645,895
Ensembl chr 8:124,661,839...125,645,898
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression ISO geldanamycin results in increased expression of RCAN1 mRNA CTD PMID:26705709 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rdh10 retinol dehydrogenase 10 increases expression ISO geldanamycin results in increased expression of RDH10 mRNA CTD PMID:26705709 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Resf1 retroelement silencing factor 1 increases expression ISO geldanamycin results in increased expression of RESF1 mRNA CTD PMID:26705709 NCBI chr 4:183,879,177...183,905,807
Ensembl chr 4:183,896,303...183,905,297
JBrowse link
G Rfx7 regulatory factor X, 7 increases expression ISO geldanamycin results in increased expression of RFX7 mRNA CTD PMID:26705709 NCBI chr 8:79,159,297...79,279,962
Ensembl chr 8:79,159,370...79,279,962
JBrowse link
G RGD1306502 similar to hypothetical protein FLJ11193 increases expression ISO geldanamycin results in increased expression of C5ORF22 mRNA CTD PMID:26705709 NCBI chr 2:62,870,871...62,887,048
Ensembl chr 2:62,870,871...62,887,048
JBrowse link
G RGD1307929 similar to CG14967-PA increases expression ISO geldanamycin results in increased expression of KIAA0100 mRNA CTD PMID:26705709 NCBI chr10:65,523,143...65,552,629
Ensembl chr10:65,523,193...65,552,348
JBrowse link
G RGD1566359 similar to RIKEN cDNA B230219D22 increases expression ISO geldanamycin results in increased expression of C5ORF24 mRNA CTD PMID:26705709 NCBI chr17:9,454,121...9,464,076
Ensembl chr17:9,457,719...9,458,288
JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase increases expression
decreases expression
ISO geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein
CTD PMID:26705709, PMID:30166341 NCBI chr 5:48,561,325...48,779,214
Ensembl chr 5:48,561,339...48,779,207
JBrowse link
G Ro60 Ro60, Y RNA binding protein increases expression ISO geldanamycin results in increased expression of RO60 mRNA CTD PMID:26705709 NCBI chr13:60,546,892...60,567,882
Ensembl chr13:60,546,912...60,567,882
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression ISO geldanamycin results in increased expression of ROCK2 mRNA CTD PMID:26705709 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 decreases expression ISO geldanamycin results in decreased expression of RPLP0 mRNA CTD PMID:30166341 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rttn rotatin increases expression ISO geldanamycin results in increased expression of RTTN mRNA CTD PMID:26705709 NCBI chr18:86,071,884...86,247,486
Ensembl chr18:86,071,662...86,247,486
JBrowse link
G Rufy2 RUN and FYVE domain containing 2 increases expression ISO geldanamycin results in increased expression of RUFY2 mRNA CTD PMID:26705709 NCBI chr20:27,219,729...27,250,006
Ensembl chr20:27,220,707...27,247,309
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO geldanamycin results in decreased expression of S100A4 mRNA CTD PMID:26705709 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Samd5 sterile alpha motif domain containing 5 increases expression ISO geldanamycin results in increased expression of SAMD5 mRNA CTD PMID:26705709 NCBI chr 1:3,713,750...3,763,392
Ensembl chr 1:3,713,750...3,763,392
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO geldanamycin results in increased expression of SAR1B mRNA CTD PMID:26705709 NCBI chr10:37,215,989...37,245,603
Ensembl chr10:37,215,937...37,245,658
JBrowse link
G Scrn3 secernin 3 increases expression ISO geldanamycin results in increased expression of SCRN3 mRNA CTD PMID:26705709 NCBI chr 3:60,023,970...60,048,746
Ensembl chr 3:60,024,013...60,048,746
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 increases expression ISO geldanamycin results in increased expression of SCYL2 mRNA CTD PMID:26705709 NCBI chr 7:30,291,087...30,344,464
Ensembl chr 7:30,291,087...30,344,445
JBrowse link
G Sema3d semaphorin 3D increases expression ISO geldanamycin results in increased expression of SEMA3D mRNA CTD PMID:26705709 NCBI chr 4:19,224,378...19,413,519
Ensembl chr 4:19,224,310...19,413,484
JBrowse link
G Senp1 SUMO specific peptidase 1 increases expression ISO geldanamycin results in increased expression of SENP1 mRNA CTD PMID:26705709 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO geldanamycin results in increased expression of SERPINE1 mRNA CTD PMID:26705709 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn3 sestrin 3 increases expression ISO geldanamycin results in increased expression of SESN3 mRNA CTD PMID:26705709 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase increases expression ISO geldanamycin results in increased expression of SETD2 mRNA CTD PMID:26705709 NCBI chr 8:118,802,478...118,888,224
Ensembl chr 8:118,803,075...118,888,224
JBrowse link
G Setx senataxin increases expression ISO geldanamycin results in increased expression of SETX mRNA CTD PMID:26705709 NCBI chr 3:7,680,430...7,731,815
Ensembl chr 3:7,686,503...7,730,539
JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO geldanamycin results in increased expression of SFPQ mRNA CTD PMID:26705709 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sgms2 sphingomyelin synthase 2 increases expression ISO geldanamycin results in increased expression of SGMS2 mRNA CTD PMID:26705709 NCBI chr 2:236,458,276...236,530,667
Ensembl chr 2:236,458,279...236,480,502
JBrowse link
G Sike1 suppressor of IKBKE 1 increases expression ISO geldanamycin results in increased expression of SIKE1 mRNA CTD PMID:26705709 NCBI chr 2:205,488,182...205,496,013
Ensembl chr 2:205,488,182...205,496,012
JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression ISO geldanamycin results in increased expression of SLAIN2 mRNA CTD PMID:26705709 NCBI chr14:37,802,347...37,880,571
Ensembl chr14:37,802,365...37,871,051
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression ISO geldanamycin results in increased expression of SLC16A1 mRNA CTD PMID:26705709 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc16a7 solute carrier family 16 member 7 increases expression ISO geldanamycin results in increased expression of SLC16A7 mRNA CTD PMID:26705709 NCBI chr 7:68,438,341...68,606,312
Ensembl chr 7:68,446,193...68,549,763
JBrowse link
G Slc2a13 solute carrier family 2 member 13 increases expression ISO geldanamycin results in increased expression of SLC2A13 mRNA CTD PMID:26705709 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression ISO geldanamycin results in increased expression of SLC38A1 mRNA CTD PMID:26705709 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO geldanamycin results in increased expression of SLC39A6 mRNA CTD PMID:26705709 NCBI chr18:16,523,450...16,543,992
Ensembl chr18:16,522,982...16,543,992
JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Slfn5 schlafen family member 5 increases expression ISO geldanamycin results in increased expression of SLFN5 mRNA CTD PMID:26705709 NCBI chr10:70,298,094...70,312,062
Ensembl chr10:70,298,519...70,312,070
JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 increases expression ISO geldanamycin results in increased expression of SMARCA2 mRNA CTD PMID:26705709 NCBI chr 1:244,615,811...244,783,736
Ensembl chr 1:244,615,821...244,782,706
JBrowse link
G Smc1a structural maintenance of chromosomes 1A increases expression ISO geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 increases expression ISO geldanamycin results in increased expression of SMCHD1 mRNA CTD PMID:26705709 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of SOS2 mRNA CTD PMID:26705709 NCBI chr 6:91,885,292...92,008,059
Ensembl chr 6:91,883,425...92,007,957
JBrowse link
G Sp4 Sp4 transcription factor increases expression ISO geldanamycin results in increased expression of SP4 mRNA CTD PMID:26705709 NCBI chr 6:146,135,877...146,201,344
Ensembl chr 6:146,135,877...146,195,819
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 increases expression ISO geldanamycin results in increased expression of SPTBN1 mRNA CTD PMID:26705709 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO
EXP
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]
CTD PMID:10401681, PMID:17223712 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srpra SRP receptor subunit alpha increases expression ISO geldanamycin results in increased expression of SRPR mRNA CTD PMID:26705709 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO geldanamycin results in increased expression of SRRM2 mRNA CTD PMID:26705709 NCBI chr10:13,128,820...13,162,956
Ensembl chr10:13,145,099...13,162,343
JBrowse link
G Srrt serrate, RNA effector molecule increases expression ISO geldanamycin results in increased expression of SRRT mRNA CTD PMID:26705709 NCBI chr12:22,457,898...22,471,090 JBrowse link
G Strn4 striatin 4 decreases expression ISO geldanamycin results in decreased expression of STRN4 mRNA CTD PMID:30166341 NCBI chr 1:78,739,930...78,765,696
Ensembl chr 1:78,735,678...78,765,692
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] CTD PMID:16037132, PMID:25645596 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit increases expression ISO geldanamycin results in increased expression of SUPT16H mRNA CTD PMID:26705709 NCBI chr15:28,574,841...28,611,959
Ensembl chr15:28,575,480...28,611,946
JBrowse link
G Tead1 TEA domain transcription factor 1 increases expression ISO geldanamycin results in increased expression of TEAD1 mRNA CTD PMID:26705709 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 increases expression ISO geldanamycin results in increased expression of TET2 mRNA CTD PMID:26705709 NCBI chr 2:238,719,389...238,802,975
Ensembl chr 2:238,720,835...238,803,024
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO geldanamycin results in increased expression of TFPI mRNA CTD PMID:26705709 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO geldanamycin results in increased expression of TGFB2 mRNA CTD PMID:26705709 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO geldanamycin results in increased expression of THBS1 mRNA CTD PMID:26705709 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tle4 TLE family member 4, transcriptional corepressor increases expression ISO geldanamycin results in increased expression of TLE4 mRNA CTD PMID:26705709 NCBI chr 1:231,394,606...231,531,396
Ensembl chr 1:231,393,379...231,530,786
JBrowse link
G Tlk1 tousled-like kinase 1 increases expression ISO geldanamycin results in increased expression of TLK1 mRNA CTD PMID:26705709 NCBI chr 3:57,012,738...57,376,336
Ensembl chr 3:57,013,025...57,119,001
JBrowse link
G Tll1 tolloid-like 1 increases expression ISO geldanamycin results in increased expression of TLL1 mRNA CTD PMID:26705709 NCBI chr16:27,399,467...27,597,240
Ensembl chr16:27,399,467...27,597,240
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO geldanamycin results in increased expression of TLR4 mRNA CTD PMID:26705709 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmem33 transmembrane protein 33 increases expression ISO geldanamycin results in increased expression of TMEM33 mRNA CTD PMID:26705709 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link
G Tmod3 tropomodulin 3 increases expression ISO geldanamycin results in increased expression of TMOD3 mRNA CTD PMID:26705709 NCBI chr 8:82,432,165...82,492,243
Ensembl chr 8:82,432,169...82,492,243
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 increases expression ISO geldanamycin results in increased expression of TMTC3 mRNA CTD PMID:26705709 NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:11472980, PMID:12571865 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression ISO geldanamycin results in increased expression of TNFRSF10D mRNA CTD PMID:26705709 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO geldanamycin results in decreased expression of TNFSF15 mRNA CTD PMID:26705709 NCBI chr 5:79,553,935...79,569,974
Ensembl chr 5:79,553,742...79,570,073
JBrowse link
G Tnks2 tankyrase 2 increases expression ISO geldanamycin results in increased expression of TNKS2 mRNA CTD PMID:26705709
G Tob2 transducer of ERBB2, 2 increases expression ISO geldanamycin results in increased expression of TOB2 mRNA CTD PMID:26705709 NCBI chr 7:123,079,520...123,088,240
Ensembl chr 7:123,079,537...123,088,279
JBrowse link
G Tp53 tumor protein p53 affects localization
affects expression
multiple interactions
ISO geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]
CTD PMID:17293044, PMID:24211270 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO geldanamycin results in increased expression of TP53BP1 mRNA CTD PMID:26705709 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO geldanamycin results in increased expression of TPM4 mRNA CTD PMID:26705709 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Tpp2 tripeptidyl peptidase 2 increases expression ISO geldanamycin results in increased expression of TPP2 mRNA CTD PMID:26705709 NCBI chr 9:50,664,048...50,744,803
NCBI chr 9:50,578,868...50,628,943
Ensembl chr 9:50,581,234...50,744,803
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO geldanamycin results in increased expression of TPR mRNA CTD PMID:26705709 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Trim59 tripartite motif-containing 59 increases expression ISO geldanamycin results in increased expression of TRIM59 mRNA CTD PMID:26705709 NCBI chr 2:165,629,903...165,641,751
Ensembl chr 2:165,629,918...165,641,573
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression ISO geldanamycin results in increased expression of TRPC6 mRNA CTD PMID:26705709 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1] CTD PMID:11930156 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression ISO geldanamycin results in increased expression of TTC3 mRNA CTD PMID:26705709 NCBI chr11:34,598,324...34,739,986
Ensembl chr11:34,598,492...34,738,791
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 increases expression ISO geldanamycin results in increased expression of TTC37 mRNA CTD PMID:26705709 NCBI chr 2:2,891,265...3,037,602
Ensembl chr 2:2,903,492...3,004,553
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO geldanamycin results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H increases expression ISO geldanamycin results in increased expression of UBE2H mRNA CTD PMID:26705709 NCBI chr 4:57,511,418...57,625,147
Ensembl chr 4:57,511,418...57,625,257
JBrowse link
G Ubn2 ubinuclein 2 increases expression ISO geldanamycin results in increased expression of UBN2 mRNA CTD PMID:26705709 NCBI chr 4:66,164,639...66,254,297
Ensembl chr 4:66,165,845...66,233,230
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO geldanamycin results in increased expression of UGCG mRNA CTD PMID:26705709 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 increases expression ISO geldanamycin results in increased expression of UGGT1 mRNA CTD PMID:26705709 NCBI chr 9:42,692,156...42,805,680
Ensembl chr 9:42,692,105...42,805,673
JBrowse link
G Uhmk1 U2AF homology motif kinase 1 increases expression ISO geldanamycin results in increased expression of UHMK1 mRNA CTD PMID:26705709 NCBI chr13:88,521,625...88,536,728
Ensembl chr13:88,521,625...88,536,728
JBrowse link
G Usp10 ubiquitin specific peptidase 10 increases expression ISO geldanamycin results in increased expression of USP10 mRNA CTD PMID:26705709 NCBI chr19:52,566,274...52,608,820
Ensembl chr19:52,566,607...52,608,817
JBrowse link
G Usp12 ubiquitin specific peptidase 12 increases expression ISO geldanamycin results in increased expression of USP12 mRNA CTD PMID:26705709 NCBI chr12:10,037,686...10,087,685
Ensembl chr12:10,063,117...10,087,685
JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression ISO geldanamycin results in increased expression of USP25 mRNA CTD PMID:26705709 NCBI chr11:15,436,080...15,558,646
Ensembl chr11:15,436,269...15,558,646
JBrowse link
G Usp36 ubiquitin specific peptidase 36 increases expression ISO geldanamycin results in increased expression of USP36 mRNA CTD PMID:26705709 NCBI chr10:107,292,828...107,324,355
Ensembl chr10:107,292,828...107,324,355
JBrowse link
G Vapb VAMP associated protein B and C increases expression ISO geldanamycin results in increased expression of VAPB mRNA CTD PMID:26705709 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
G Vdac3 voltage-dependent anion channel 3 decreases expression ISO geldanamycin results in decreased expression of VDAC3 mRNA CTD PMID:30166341 NCBI chr16:74,292,466...74,308,910
Ensembl chr16:74,292,438...74,308,903
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO geldanamycin results in increased expression of VMP1 mRNA CTD PMID:26705709 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Vps50 VPS50 subunit of EARP/GARPII complex increases expression ISO geldanamycin results in increased expression of VPS50 mRNA CTD PMID:26705709 NCBI chr 4:28,441,255...28,551,784
Ensembl chr 4:28,441,301...28,551,784
JBrowse link
G Zbed6 zinc finger, BED-type containing 6 increases expression ISO geldanamycin results in increased expression of ZBED6 mRNA CTD PMID:26705709 NCBI chr13:50,196,143...50,211,670 JBrowse link
G Zc3h11a zinc finger CCCH-type containing 11A increases expression ISO geldanamycin results in increased expression of ZC3H11A mRNA CTD PMID:26705709 NCBI chr13:50,196,042...50,234,862
Ensembl chr13:50,196,042...50,234,862
JBrowse link
G Zfhx4 zinc finger homeobox 4 increases expression ISO geldanamycin results in increased expression of ZFHX4 mRNA CTD PMID:26705709 NCBI chr 2:98,423,565...98,610,368
Ensembl chr 2:98,423,569...98,610,368
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO geldanamycin results in decreased expression of ZNF207 mRNA CTD PMID:30166341 NCBI chr10:67,762,970...67,784,854
Ensembl chr10:67,762,995...67,774,787
JBrowse link
G Zfp326 zinc finger protein 326 increases expression ISO geldanamycin results in increased expression of ZNF326 mRNA CTD PMID:26705709 NCBI chr14:4,998,530...5,006,759
NCBI chr14:5,016,764...5,036,663
Ensembl chr14:4,998,539...5,033,942
JBrowse link
G Zfp518a zinc finger protein 518A increases expression ISO geldanamycin results in increased expression of ZNF518A mRNA CTD PMID:26705709 NCBI chr 1:260,152,881...260,178,360
Ensembl chr 1:260,153,645...260,178,349
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO geldanamycin results in increased expression of ZNF638 mRNA CTD PMID:26705709 NCBI chr 4:115,555,185...115,690,272
Ensembl chr 4:115,601,661...115,690,272
JBrowse link
G Zfp655 zinc finger protein 655 increases expression ISO geldanamycin results in increased expression of ZNF655 mRNA CTD PMID:26705709 NCBI chr12:11,122,779...11,146,182
Ensembl chr12:11,127,754...11,144,754
JBrowse link
G Zfp704 zinc finger protein 704 increases expression ISO geldanamycin results in increased expression of ZNF704 mRNA CTD PMID:26705709 NCBI chr 2:94,377,059...94,559,838
Ensembl chr 2:94,377,072...94,551,529
JBrowse link
G Zfp711 zinc finger protein 711 increases expression ISO geldanamycin results in increased expression of ZNF711 mRNA CTD PMID:26705709 NCBI chr  X:84,062,363...84,095,888
Ensembl chr  X:84,064,427...84,096,617
JBrowse link
G Zfp770 zinc finger protein 770 increases expression ISO geldanamycin results in increased expression of ZNF770 mRNA CTD PMID:26705709 NCBI chr 3:105,658,970...105,667,227
Ensembl chr 3:105,661,044...105,663,457
JBrowse link
G Zfr zinc finger RNA binding protein increases expression ISO geldanamycin results in increased expression of ZFR mRNA CTD PMID:26705709 NCBI chr 2:62,150,251...62,213,048
Ensembl chr 2:62,150,251...62,213,048
JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO geldanamycin results in increased expression of ZFX mRNA CTD PMID:26705709 NCBI chr  X:63,158,368...63,204,971
Ensembl chr  X:63,158,976...63,204,530
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 increases expression ISO geldanamycin results in increased expression of ZMYND11 mRNA CTD PMID:26705709 NCBI chr17:63,825,616...63,914,740
Ensembl chr17:63,825,627...63,879,171
JBrowse link
G Znf660 zinc finger protein 660 increases expression ISO geldanamycin results in increased expression of ZNF660 mRNA CTD PMID:26705709 NCBI chr 8:131,955,636...131,968,550
Ensembl chr 8:131,965,134...131,966,540
JBrowse link
G Zxdc ZXD family zinc finger C increases expression ISO geldanamycin results in increased expression of ZXDC mRNA CTD PMID:26705709 NCBI chr 4:122,282,119...122,314,251
Ensembl chr 4:122,282,279...122,312,879
JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
CTD PMID:25968939 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
CTD PMID:25968939 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein
CTD PMID:25968939 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Tfrc transferrin receptor increases expression ISO ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
leupeptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] CTD PMID:21818627 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aqp8 aquaporin 8 multiple interactions EXP leupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein] CTD PMID:17110522 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein] CTD PMID:16242776 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp6 caspase 6 multiple interactions ISO leupeptin inhibits the reaction [Estradiol results in increased degradation of and results in decreased activity of CASP6 protein] CTD PMID:15086513 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
increases expression
ISO leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]
leupeptin results in increased expression of CDC25C protein
CTD PMID:29074359 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein] CTD PMID:19464575 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cip2a cellular inhibitor of PP2A multiple interactions ISO leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr11:54,373,794...54,404,704
Ensembl chr11:54,377,374...54,404,612
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CTNNB1 protein] CTD PMID:19464575 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsb cathepsin B multiple interactions ISO leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Egf epidermal growth factor decreases degradation ISO leupeptin results in decreased degradation of EGF protein CTD PMID:23125191 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO leupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL1A protein] CTD PMID:21818627 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 multiple interactions ISO leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] CTD PMID:21818627 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klk8 kallikrein related-peptidase 8 decreases activity ISO leupeptin results in decreased activity of KLK8 protein CTD PMID:16800733 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
JBrowse link
G Nefl neurofilament light multiple interactions ISO leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Plin1 perilipin 1 multiple interactions
decreases degradation
ISO leupeptin inhibits the reaction [Nelfinavir results in increased degradation of PLIN1 protein]
leupeptin results in decreased degradation of PLIN1 protein
CTD PMID:17488708 NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP leupeptin results in increased expression of TGFBR1 protein CTD PMID:27826032 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
sciadopitysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO sciadopitysin results in decreased activity of ABCB1 protein
sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
CTD PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO sciadopitysin results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD PMID:23624148 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:23624148 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
tanespimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein CTD PMID:31370342 NCBI chr12:24,722,277...24,725,760
Ensembl chr12:24,722,283...24,724,997
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein CTD PMID:31370342 NCBI chr 1:266,123,864...266,142,621
Ensembl chr 1:266,123,870...266,142,538
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO tanespimycin results in increased expression of ADAMTS1 mRNA CTD PMID:19514085 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein
CTD PMID:31370342 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Ak9 adenylate kinase 9 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein CTD PMID:31370342 NCBI chr20:46,044,901...46,162,015
Ensembl chr20:46,044,892...46,162,073
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
ISO
EXP
Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:16923571, PMID:17157164, PMID:18566239, PMID:22810956 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]
CTD PMID:18393300 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein CTD PMID:31370342 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alk ALK receptor tyrosine kinase decreases activity
decreases expression
ISO tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form
CTD PMID:21030459, PMID:21502504 NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
JBrowse link
G Anxa1 annexin A1 increases expression ISO tanespimycin results in increased expression of ANXA1 protein CTD PMID:31370342 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
ISO Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor decreases expression ISO tanespimycin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein CTD PMID:31370342 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO tanespimycin analog results in decreased expression of ATP5F1B protein CTD PMID:31370342 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanespimycin results in decreased expression of BCL2 protein CTD PMID:16923571, PMID:28673683 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO tanespimycin results in decreased expression of BCL2L1 protein CTD PMID:16923571 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO tanespimycin results in increased expression of BCL2L11 protein CTD PMID:24784839 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase increases expression
decreases expression
ISO
EXP
tanespimycin analog results in increased expression of BRAF protein
tanespimycin results in decreased expression of BRAF protein
CTD PMID:22810956, PMID:31370342 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
[tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
tanespimycin results in increased cleavage of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15993848, PMID:17157164, PMID:18194434, PMID:19913524, PMID:22810956, PMID:24189122 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein
CTD PMID:17121904 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein
CTD PMID:17121904 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein
CTD PMID:17121904, PMID:17157164 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein CTD PMID:31370342 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO
EXP
[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein
CTD PMID:21156818, PMID:22810956 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
tanespimycin results in decreased expression of CDK1 protein
CTD PMID:21156818, PMID:24784839 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164, PMID:28673683 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk8 cyclin-dependent kinase 8 decreases expression ISO tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 NCBI chr12:10,496,273...10,561,335 JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO tanespimycin analog results in increased expression of CES1 protein CTD PMID:31370342 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chp2 calcineurin-like EF hand protein 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein CTD PMID:31370342 NCBI chr 1:192,169,634...192,173,228
Ensembl chr 1:192,169,841...192,173,253
JBrowse link
G Commd1 copper metabolism domain containing 1 multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Csde1 cold shock domain containing E1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein CTD PMID:31370342 NCBI chr 2:205,525,194...205,552,987
Ensembl chr 2:205,525,204...205,552,991
JBrowse link
G Cttn cortactin multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
tanespimycin analog results in increased expression of CTTN protein
CTD PMID:31370342 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of tanespimycin CTD PMID:15718306 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein CTD PMID:31370342 NCBI chr13:45,074,067...45,127,815
Ensembl chr13:45,074,072...45,127,815
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO tanespimycin results in increased expression of DHRS2 protein CTD PMID:31370342 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression ISO tanespimycin analog results in increased expression of EBF2 protein CTD PMID:31370342 NCBI chr15:43,905,099...44,103,742
Ensembl chr15:43,905,099...44,103,742
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein CTD PMID:31370342 NCBI chr17:76,002,304...76,022,813
Ensembl chr17:76,002,275...76,022,813
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
tanespimycin analog results in decreased expression of EEF1G protein
CTD PMID:31370342 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein
CTD PMID:31370342 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein
CTD PMID:16061882, PMID:17010675, PMID:22810956, PMID:31370342 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of EIF3I protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein
CTD PMID:31370342 NCBI chr 5:147,796,580...147,803,853
Ensembl chr 5:147,796,662...147,803,851
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein CTD PMID:31370342 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein CTD PMID:31370342 NCBI chr12:25,093,119...25,109,805
Ensembl chr12:25,093,149...25,109,799
JBrowse link
G Eml5 EMAP like 5 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein
CTD PMID:31370342 NCBI chr 6:122,768,939...122,898,046
Ensembl chr 6:122,770,055...122,897,997
JBrowse link
G Eno1 enolase 1 increases expression ISO tanespimycin analog results in increased expression of ENO1 protein CTD PMID:31370342 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein
CTD PMID:16061882, PMID:24784839 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Eri1 exoribonuclease 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein CTD PMID:31370342 NCBI chr16:60,307,148...60,327,237
Ensembl chr16:60,307,148...60,327,236
JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein CTD PMID:31370342 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein
tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein
CTD PMID:31370342 NCBI chr 9:84,324,456...84,383,674
Ensembl chr 9:84,324,442...84,383,687
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein CTD PMID:31370342 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 multiple interactions ISO tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein CTD PMID:16061882 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO tanespimycin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Fubp1 far upstream element binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein CTD PMID:31370342 NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568
JBrowse link
G Gcfc2 GC-rich sequence DNA-binding factor 2 increases expression ISO tanespimycin analog results in increased expression of GCFC2 protein CTD PMID:31370342 NCBI chr 4:112,662,556...112,700,505
Ensembl chr 4:112,662,609...112,699,711
JBrowse link
G Gls glutaminase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein CTD PMID:31370342 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanespimycin results in decreased expression of GSK3B protein modified form CTD PMID:20090934 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression ISO tanespimycin analog results in increased expression of GTF2A2 protein CTD PMID:31370342 NCBI chr 8:76,422,341...76,435,587
Ensembl chr 8:76,422,359...76,435,473
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein CTD PMID:31370342 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein CTD PMID:31370342 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein
CTD PMID:31370342 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization
multiple interactions
ISO tanespimycin affects the localization of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
CTD PMID:20090934 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
affects binding
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein
CTD PMID:18830594, PMID:22895790, PMID:31370342 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding ISO tanespimycin binds to HSP90AB1 protein CTD PMID:22895790 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
ISO [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein
CTD PMID:20090934, PMID:31370342 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein CTD PMID:31370342 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tanespimycin results in increased expression of HSPA5 protein CTD PMID:16357177 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein
CTD PMID:23144451, PMID:31370342 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression
decreases expression
ISO
EXP
tanespimycin affects the expression of IGF1R protein
tanespimycin results in decreased expression of IGF1R protein
CTD PMID:22810956 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein CTD PMID:31370342 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
JBrowse link
G Kcnv2 potassium voltage-gated channel modifier subfamily V member 2 decreases expression
multiple interactions
ISO tanespimycin analog results in decreased expression of KCNV2 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein
CTD PMID:31370342 NCBI chr 1:245,396,880...245,475,011
Ensembl chr 1:245,396,989...245,416,531
JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein CTD PMID:31370342 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kdr kinase insert domain receptor affects expression
decreases expression
ISO
EXP
tanespimycin affects the expression of KDR protein
tanespimycin results in decreased expression of KDR protein
CTD PMID:22810956 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
ISO
EXP
tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein
CTD PMID:16061882, PMID:16213582, PMID:22810956 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO tanespimycin analog results in increased expression of LARP7 protein CTD PMID:31370342 NCBI chr 2:231,866,888...231,882,002
Ensembl chr 2:231,867,135...231,881,939
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of LCP1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein
CTD PMID:31370342 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein CTD PMID:31370342 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO tanespimycin analog results in increased expression of LDHB protein CTD PMID:31370342 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Lmna lamin A/C multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein CTD PMID:31370342 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein CTD PMID:31370342 NCBI chr 6:7,984,043...8,066,874
Ensembl chr 6:7,984,019...8,066,868
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO tanespimycin results in decreased expression of MCL1 protein CTD PMID:16923571 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene increases degradation ISO tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP
ISO
tanespimycin results in decreased expression of MET protein CTD PMID:22810956 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions
decreases expression
ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein
CTD PMID:31370342 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mllt10 MLLT10, histone lysine methyltransferase DOT1L cofactor multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein CTD PMID:31370342 NCBI chr17:84,847,660...84,981,134
Ensembl chr17:84,881,414...84,979,543
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA] CTD PMID:21401309 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA] CTD PMID:21401309 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msn moesin increases expression ISO tanespimycin analog results in increased expression of MSN protein CTD PMID:31370342 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mtap methylthioadenosine phosphorylase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein CTD PMID:31370342 NCBI chr 5:107,711,077...107,777,530
Ensembl chr 5:107,711,077...107,777,530
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO tanespimycin results in increased expression of MTSS1 mRNA CTD PMID:19514085 NCBI chr 7:98,820,799...98,960,878
Ensembl chr 7:98,820,812...98,960,837
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein CTD PMID:31370342 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nans N-acetylneuraminate synthase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein CTD PMID:31370342 NCBI chr 5:62,109,352...62,126,492
Ensembl chr 5:62,109,328...62,126,494
JBrowse link
G Ncl nucleolin multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein CTD PMID:31370342 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
decreases phosphorylation
EXP
ISO
tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein
CTD PMID:11835313, PMID:22810956 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
increases reduction
increases abundance
ISO [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased susceptibility to tanespimycin
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite
CTD PMID:10564678, PMID:21156818, PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein CTD PMID:31370342 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein
tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein
CTD PMID:31370342 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage EXP
ISO
tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases expression ISO tanespimycin analog results in increased expression of PARP2 protein CTD PMID:31370342 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO
EXP
tanespimycin results in decreased expression of PDGFRB protein CTD PMID:22810956 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein CTD PMID:31370342 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pfn1 profilin 1 increases expression ISO tanespimycin analog results in increased expression of PFN1 protein CTD PMID:31370342 NCBI chr10:57,273,003...57,275,708
Ensembl chr10:57,273,005...57,275,708
JBrowse link
G Pgr progesterone receptor decreases expression ISO tanespimycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein CTD PMID:31370342 NCBI chr 7:70,483,948...70,498,995
Ensembl chr 7:70,483,942...70,498,995
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO tanespimycin results in decreased expression of PKM protein CTD PMID:31370342 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pnn pinin, desmosome associated protein increases expression ISO tanespimycin results in increased expression of PNN mRNA CTD PMID:19514085 NCBI chr 6:80,159,364...80,167,677
Ensembl chr 6:80,159,364...80,167,677
JBrowse link
G Prkrip1 PRKR interacting protein 1 increases expression ISO tanespimycin analog results in increased expression of PRKRIP1 protein CTD PMID:31370342 NCBI chr12:23,514,987...23,533,278
Ensembl chr12:23,514,981...23,535,968
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein CTD PMID:31370342 NCBI chr  X:28,435,275...28,472,882
Ensembl chr  X:28,435,507...28,472,880
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein CTD PMID:31370342 NCBI chr 6:76,174,460...76,205,429
Ensembl chr 6:76,174,452...76,205,426
JBrowse link
G Psma7 proteasome 20S subunit alpha 7 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein CTD PMID:31370342 NCBI chr 3:175,420,042...175,426,384
Ensembl chr 3:175,420,039...175,426,395
JBrowse link
G Rab17 RAB17, member RAS oncogene family multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein CTD PMID:31370342 NCBI chr 9:98,118,907...98,131,883
Ensembl chr 9:98,118,908...98,131,883
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO tanespimycin results in decreased expression of RAF1 protein CTD PMID:10564678 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein
CTD PMID:17121904 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rdx radixin increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of RDX protein
[tanespimycin co-treated with VER 155008] results in increased expression of RDX protein
CTD PMID:31370342 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein CTD PMID:31370342 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
ISO tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein
CTD PMID:17121904, PMID:27255535 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Selenbp1 selenium binding protein 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein CTD PMID:31370342 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO tanespimycin results in increased expression of SERPINB5 mRNA CTD PMID:19514085 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 decreases expression ISO tanespimycin analog results in decreased expression of SHMT2 protein CTD PMID:31370342 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Sod2 superoxide dismutase 2 increases abundance
increases response to substance
ISO SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin
CTD PMID:21156818 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 increases expression
multiple interactions
ISO tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein
CTD PMID:31370342 NCBI chr10:85,460,059...85,517,671
Ensembl chr10:85,460,059...85,517,683
JBrowse link
G Tagln2 transgelin 2 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein CTD PMID:31370342 NCBI chr13:90,807,196...90,814,119
Ensembl chr13:90,807,199...90,814,119
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO tanespimycin results in increased expression of TIMP3 mRNA CTD PMID:19514085 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein CTD PMID:15993848 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO tanespimycin results in decreased expression of TP53 protein CTD PMID:10564678 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 increases expression ISO tanespimycin analog results in increased expression of TPTE2 protein CTD PMID:31370342 NCBI chr16:74,552,859...74,662,194
Ensembl chr16:74,558,529...74,662,194
JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions
ISO tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]
CTD PMID:30796972 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO tanespimycin results in decreased expression of TYMS protein CTD PMID:18830594 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein CTD PMID:31370342 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 decreases expression ISO tanespimycin results in decreased expression of UGP2 protein CTD PMID:31370342 NCBI chr14:106,208,174...106,249,322
Ensembl chr14:106,208,176...106,248,539
JBrowse link
G Vil1 villin 1 increases expression ISO tanespimycin analog results in increased expression of VIL1 protein CTD PMID:31370342 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:15993848 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 multiple interactions ISO [tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein CTD PMID:31370342 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator multiple interactions
increases expression
ISO [tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein
tanespimycin analog results in increased expression of ZYG11B protein
CTD PMID:31370342 NCBI chr 5:127,844,062...127,878,792
Ensembl chr 5:127,847,129...127,878,792
JBrowse link
Z-Val-Phe-H term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:16891617 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Capn1 calpain 1 multiple interactions
decreases activity
ISO
EXP
calpain inhibitor III inhibits the reaction [CAPN1 protein results in increased susceptibility to Cisplatin]
calpain inhibitor III inhibits the reaction [Calcium results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]
calpain inhibitor III results in decreased activity of CAPN1 protein
CTD PMID:13678654, PMID:20878076, PMID:21985864, PMID:29289695 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 multiple interactions EXP calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:16891617 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein] CTD PMID:19336499 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1a interleukin 1 alpha affects localization ISO calpain inhibitor III affects the localization of IL1A protein CTD PMID:24024155 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Nefl neurofilament light multiple interactions EXP calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein] CTD PMID:15275793 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA] CTD PMID:15316131 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions ISO
EXP
calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]
calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]
CTD PMID:21683092, PMID:21985864 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA] CTD PMID:15316131 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          enzyme inhibitor 18163
            EC 3.* (hydrolase) inhibitor 17660
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3219
                EC 3.4.22.* (cysteine endopeptidase) inhibitor 555
                  EC 3.4.22.2 (papain) inhibitor + 0
                  EC 3.4.22.36 (caspase-1) inhibitor + 0
                  EC 3.4.22.38 (cathepsin K) inhibitor + 0
                  EC 3.4.22.56 (caspase-3) inhibitor + 0
                  EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor + 5
                  calpain inhibitor + 27
                  cathepsin L (EC 3.4.22.15) inhibitor + 0
                  cysteine protease inhibitor + 551
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.