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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.22.* (cysteine endopeptidase) inhibitor
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Accession:CHEBI:76796 term browser browse the term
Definition:An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any cysteine endopeptidase (EC 3.4.22.*).
Synonyms:related_synonym: EC 3.4.22.* inhibitor;   EC 3.4.22.* inhibitors;   cysteine endopeptidase (EC 3.4.22.*) inhibitors;   cysteine endopeptidase inhibitor;   cysteine endopeptidase inhibitors



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ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552
JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116
JBrowse link
menadione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 multiple interactions
increases activity
EXP SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein] CTD PMID:18086661 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G CAPN2 calpain 2 increases expression
increases cleavage
EXP Vitamin K 3 results in increased expression of CAPN2 protein
Vitamin K 3 results in increased cleavage of CAPN2 protein
CTD PMID:16920763 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,757...19,820,246
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
EXP PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSP90B1 protein]
Vitamin K 3 results in increased expression of HSP90B1 mRNA; Vitamin K 3 results in increased expression of HSP90B1 protein
CTD PMID:16920763 PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]
Vitamin K 3 results in increased expression of HSPA5 mRNA; Vitamin K 3 results in increased expression of HSPA5 protein
CTD PMID:16920763 PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Vitamin K 3 results in increased phosphorylation of MAPK8 protein CTD PMID:18086661 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G SOD2 superoxide dismutase 2 decreases response to substance
multiple interactions
EXP SOD2 results in decreased susceptibility to Vitamin K 3
SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein]
CTD PMID:18086661 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TPO thyroid peroxidase decreases activity EXP Vitamin K 3 results in decreased activity of TPO protein CTD PMID:11815678 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
JBrowse link
G XBP1 X-box binding protein 1 increases splicing EXP Vitamin K 3 results in increased splicing of XBP1 mRNA CTD PMID:18086661 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5059
    role 5022
      biological role 5022
        biochemical role 4942
          enzyme inhibitor 492
            EC 3.* (hydrolase) inhibitor 429
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 31
                EC 3.4.22.* (cysteine endopeptidase) inhibitor 10
                  EC 3.4.22.2 (papain) inhibitor + 0
                  EC 3.4.22.36 (caspase-1) inhibitor + 0
                  EC 3.4.22.38 (cathepsin K) inhibitor + 0
                  EC 3.4.22.56 (caspase-3) inhibitor + 0
                  EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor + 10
                  calpain inhibitor + 0
                  cathepsin L (EC 3.4.22.15) inhibitor + 0
                  cysteine protease inhibitor + 0
paths to the root