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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.22.* (cysteine endopeptidase) inhibitor
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Accession:CHEBI:76796 term browser browse the term
Definition:An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any cysteine endopeptidase (EC 3.4.22.*).
Synonyms:related_synonym: EC 3.4.22.* inhibitor;   EC 3.4.22.* inhibitors;   cysteine endopeptidase (EC 3.4.22.*) inhibitors;   cysteine endopeptidase inhibitor;   cysteine endopeptidase inhibitors



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5,6,7-trimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] CTD PMID:24161485 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:24161485 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:24161485 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] CTD PMID:24161485 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:24161485 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide CTD PMID:24161485 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone CTD PMID:24161485 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:24161485 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] CTD PMID:24161485 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] CTD PMID:24161485 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:24161485 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
acetylleucyl-leucyl-norleucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G APOB apolipoprotein B multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Glucosamine results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal results in increased expression of and results in increased secretion of APOB protein CTD PMID:19342510 PMID:19383982 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of BIRC5 protein] CTD PMID:29974605 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CAPN1 calpain 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased expression of CAPN1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Acrylamide results in increased expression of CAPN1 protein] CTD PMID:35713544 PMID:37353096 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN2 calpain 2 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased expression of CAPN2 protein] CTD PMID:35713544 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
ISO acetylleucyl-leucyl-norleucinal results in increased activity of CASP3 protein
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:15618349 PMID:27481217 PMID:29111403 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP7 caspase 7 multiple interactions EXP acetylleucyl-leucyl-norleucinal promotes the reaction [Immunologic Factors results in increased expression of CASP7 protein modified form] CTD PMID:29974605 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CAST calpastatin multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased cleavage of CAST protein] CTD PMID:35713544 NCBI chr 5:95,961,429...96,774,683
Ensembl chr 5:96,525,267...96,779,595
Ensembl chr 5:96,525,267...96,779,595
JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] CTD PMID:17373649 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Resveratrol results in increased degradation of CCND1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND1 protein] CTD PMID:11895924 PMID:16024653 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND3 cyclin D3 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein] CTD PMID:16024653 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357
JBrowse link
G CDC20 cell division cycle 20 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]; acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein] CTD PMID:20054826 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of CTNNB1 protein] CTD PMID:29974605 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Antimycin A inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; diphenyleneiodonium inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Rotenone inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA] CTD PMID:12208513 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G DNM1L dynamin 1 like multiple interactions ISO acetylleucyl-leucyl-norleucinal affects the reaction [Acetaminophen affects the phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased expression of and results in increased cleavage of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:27481217 PMID:35713544 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G EIF4E eukaryotic translation initiation factor 4E multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,879,276...98,929,133
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:35713544 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acrylamide results in decreased expression of HSPA9 protein] CTD PMID:37353096 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] CTD PMID:17291458 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G INS-IGF2 INS-IGF2 readthrough decreases secretion ISO acetylleucyl-leucyl-norleucinal results in decreased secretion of INS1 protein CTD PMID:15618349 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP acetylleucyl-leucyl-norleucinal promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G ITPR3 inositol 1,4,5-trisphosphate receptor type 3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acrylamide results in decreased expression of ITPR3 protein] CTD PMID:37353096 NCBI chr 6:33,621,322...33,696,562
Ensembl chr 6:33,620,365...33,696,574
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of JUN protein CTD PMID:15618349 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of MAPK8 protein CTD PMID:15618349 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G MFN2 mitofusin 2 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in decreased expression of and results in increased cleavage of MFN2 protein] CTD PMID:35713544 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of MYC protein] CTD PMID:29974605 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
decreases degradation
EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased degradation of and results in decreased expression of NFKBIA protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein]
acetylleucyl-leucyl-norleucinal results in decreased degradation of NFKBIA protein
CTD PMID:15930313 PMID:17291458 PMID:18606398 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased cleavage of PPP3CA protein] CTD PMID:35713544 NCBI chr 4:101,023,418...101,347,526
Ensembl chr 4:101,023,409...101,348,278
JBrowse link
G RAD51 RAD51 recombinase multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] CTD PMID:21810436 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region increases expression EXP acetylleucyl-leucyl-norleucinal results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr 4:26,105,449...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G SCNN1G sodium channel epithelial 1 subunit gamma increases methylation
decreases expression
EXP acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoter
acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNA
CTD PMID:15564131 NCBI chr16:23,182,745...23,216,883
Ensembl chr16:23,182,745...23,216,883
JBrowse link
G SLC38A3 solute carrier family 38 member 3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 3:50,205,271...50,221,486
Ensembl chr 3:50,205,246...50,221,486
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [SGA 360 results in increased degradation of and results in decreased expression of SREBF1 protein] CTD PMID:31225620 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G TTN titin multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein] CTD PMID:22532871 NCBI chr 2:178,525,989...178,807,423
Ensembl chr 2:178,525,989...178,830,802
JBrowse link
G TYMP thymidine phosphorylase multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] CTD PMID:21444628 PMID:30796972 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G TYMS thymidylate synthetase multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein] CTD PMID:21444628 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
aloxistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 multiple interactions EXP aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN7 calpain 7 multiple interactions EXP aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 3:15,206,246...15,252,916
Ensembl chr 3:15,206,152...15,252,916
JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO
[aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]
[Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein
CTD PMID:26853465 PMID:33186601 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions EXP aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein] CTD PMID:34523043 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CTSB cathepsin B multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 PMID:32186374 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CTSD cathepsin D multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein CTD PMID:32186374 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSL cathepsin L multiple interactions EXP aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked multiple interactions EXP aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein] CTD PMID:30821613 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472
JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 multiple interactions EXP aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein] CTD PMID:30821613 NCBI chr17:7,572,825...7,579,006
Ensembl chr17:7,572,824...7,579,006
JBrowse link
G EIF4H eukaryotic translation initiation factor 4H multiple interactions EXP aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein] CTD PMID:30821613 NCBI chr 7:74,174,356...74,197,096
Ensembl chr 7:74,174,231...74,197,122
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein] CTD PMID:34523043 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO
EXP
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in increased expression of MAP1LC3B protein
aloxistatin results in increased lipidation of MAP1LC3B protein
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [ABTL0812 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [Brefeldin A results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in decreased degradation of MAP1LC3B protein modified form; aloxistatin promotes the reaction [indatraline results in increased lipidation of MAP1LC3B protein]
CTD PMID:26483381 PMID:27635674 PMID:32397857 PMID:33124469 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G SMN2 survival of motor neuron 2, centromeric multiple interactions EXP aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 5:70,049,523...70,090,528
Ensembl chr 5:70,049,638...70,078,522
Ensembl chr 5:70,049,638...70,078,522
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
increases expression
EXP
ISO
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; aloxistatin promotes the reaction [indatraline results in increased expression of SQSTM1 protein]; aloxistatin promotes the reaction [Sertraline results in increased expression of SQSTM1 protein]
aloxistatin results in increased expression of SQSTM1 protein
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein
CTD PMID:26483381 PMID:32186374 PMID:32773031 PMID:33124469 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
amentoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions EXP amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein] CTD PMID:34599948 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:28185818 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] CTD PMID:28185818 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO
EXP
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD PMID:28185818 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:28185818 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CD36 CD36 molecule (CD36 blood group) multiple interactions EXP amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]] CTD PMID:34599948 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:28185818 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP amentoflavone results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DCT dopachrome tautomerase decreases expression EXP amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein CTD PMID:17473463 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:28185818 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein] CTD PMID:28185818 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein] CTD PMID:28185818 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein] CTD PMID:28185818 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
amentoflavone results in decreased expression of NOS2 protein
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:12144868 PMID:28185818 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]] CTD PMID:34599948 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGDS prostaglandin D2 synthase affects binding EXP amentoflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein
[amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
CTD PMID:12144868 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases expression EXP amentoflavone results in decreased expression of SREBF1 mRNA CTD PMID:34599948 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:28185818 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TYR tyrosinase decreases activity EXP amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 decreases activity EXP amentoflavone results in decreased activity of UGT1A1 protein CTD PMID:29470958 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 decreases activity EXP amentoflavone results in decreased activity of UGT1A10 protein CTD PMID:29470958 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 decreases activity EXP amentoflavone results in decreased activity of UGT1A3 protein CTD PMID:29470958 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 decreases activity EXP amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 decreases activity
multiple interactions
EXP amentoflavone results in decreased activity of UGT1A6 protein
amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
CTD PMID:29470958 PMID:32421801 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 decreases activity EXP amentoflavone results in decreased activity of UGT1A7 protein CTD PMID:29470958 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 decreases activity EXP amentoflavone results in decreased activity of UGT1A8 protein CTD PMID:29470958 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 decreases activity EXP amentoflavone results in decreased activity of UGT1A9 protein CTD PMID:29470958 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 decreases activity EXP amentoflavone results in decreased activity of UGT2B17 protein CTD PMID:29470958 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413
JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 decreases activity EXP amentoflavone results in decreased activity of UGT2B4 protein CTD PMID:29470958 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014
JBrowse link
baicalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases activity
multiple interactions
increases expression
EXP baicalein results in increased activity of ABCB1 protein
baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
baicalein results in increased expression of ABCB1 protein
CTD PMID:34217736 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases activity EXP baicalein results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
baicalein results in decreased expression of ACTA2 protein
CTD PMID:30201452 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G AFP alpha fetoprotein affects binding ISO baicalein binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
affects response to substance
increases activity
increases expression
EXP
ISO
AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; baicalein binds to and results in increased activity of AHR protein
AHR protein affects the susceptibility to baicalein
baicalein results in increased activity of AHR protein
baicalein results in increased expression of AHR protein
CTD PMID:14644660 PMID:17869316 PMID:22820424 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
EXP baicalein results in decreased phosphorylation of AKT1 protein
baicalein results in increased phosphorylation of AKT1 protein
Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]
CTD PMID:18025287 PMID:22820424 PMID:36988316 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type multiple interactions
decreases activity
EXP baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
baicalein results in decreased activity of ALOX12 protein
CTD PMID:17027136 PMID:23238474 NCBI chr17:6,996,049...7,010,754
Ensembl chr17:6,996,049...7,010,754
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase decreases activity EXP baicalein results in decreased activity of ALOX15 protein CTD PMID:23238474 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO baicalein inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G ASCL3 achaete-scute family bHLH transcription factor 3 affects expression ISO baicalein affects the expression of ASCL3 protein CTD PMID:36055377 NCBI chr11:8,937,578...8,943,016
Ensembl chr11:8,937,578...8,943,016
JBrowse link
G ASCL4 achaete-scute family bHLH transcription factor 4 affects expression ISO baicalein affects the expression of ASCL4 protein CTD PMID:36055377 NCBI chr12:107,774,704...107,776,644
Ensembl chr12:107,774,704...107,776,644
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form]
baicalein results in increased expression of BAX protein
CTD PMID:20850421 PMID:21457722 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO
EXP
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form]
baicalein results in decreased expression of BCL2 protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein]
CTD PMID:20850421 PMID:33838155 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression
multiple interactions
EXP baicalein results in decreased expression of BIRC5 protein
SB 203580 inhibits the reaction [baicalein results in decreased expression of BIRC5 protein]; wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]
CTD PMID:18025287 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP3 protein modified form] CTD PMID:20850421 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form] CTD PMID:20850421 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP baicalein results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP baicalein results in decreased expression of CCNB1 protein CTD PMID:18025287 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
increases expression
EXP
ISO
Lithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA] CTD PMID:19160421 PMID:21457722 PMID:22820424 PMID:24560969 PMID:36988316 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 decreases expression ISO baicalein results in decreased expression of CCNE1 protein CTD PMID:24560969 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases phosphorylation
multiple interactions
EXP baicalein results in decreased phosphorylation of CDK1 protein
SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]; Wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]
CTD PMID:18025287 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK4 cyclin dependent kinase 4 increases expression EXP baicalein results in increased expression of CDK4 protein CTD PMID:22820424 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP baicalein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein] CTD PMID:34624459 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression ISO baicalein results in decreased expression of CEBPA protein CTD PMID:24560969 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta decreases expression ISO baicalein results in decreased expression of CEBPB mRNA CTD PMID:24560969 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CEBPG CCAAT enhancer binding protein gamma decreases expression ISO baicalein results in decreased expression of CEBPG mRNA CTD PMID:24560969 NCBI chr19:33,373,709...33,382,686
Ensembl chr19:33,373,685...33,382,686
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions ISO baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein] CTD PMID:20850421 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CFTR CF transmembrane conductance regulator increases activity EXP baicalein results in increased activity of CFTR protein CTD PMID:15234961 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:30201452 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions ISO baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G CSF2 colony stimulating factor 2 decreases expression EXP baicalein results in decreased expression of CSF2 mRNA CTD PMID:10718847 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of CYCS protein] CTD PMID:20850421 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
decreases expression
multiple interactions
increases chemical synthesis
decreases activity
EXP baicalein results in increased expression of CYP1A1 protein
baicalein results in decreased expression of CYP1A1 mRNA
[CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased chemical synthesis of baicalein
baicalein results in decreased activity of CYP1A1 protein
CTD PMID:12224597 PMID:14644660 PMID:18451504 PMID:19666078 PMID:21053930 More... NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
increases chemical synthesis
multiple interactions
EXP baicalein results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased chemical synthesis of baicalein
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
CTD PMID:19666078 PMID:21053930 PMID:29753067 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity
increases chemical synthesis
multiple interactions
EXP baicalein results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased chemical synthesis of baicalein
[CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein binds to and results in decreased activity of CYP1B1 protein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]
CTD PMID:12224597 PMID:19666078 PMID:21053930 PMID:21482471 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP baicalein results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP baicalein results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
decreases activity
EXP baicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
baicalein results in decreased activity of CYP2C9 protein
CTD PMID:21053930 PMID:29753067 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP baicalein results in decreased activity of CYP2E1 protein CTD PMID:29753067 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP baicalein results in decreased activity of CYP3A4 protein CTD PMID:21053930 PMID:29753067 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 decreases expression ISO baicalein results in decreased expression of DGAT1 protein CTD PMID:24560969 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 increases expression ISO baicalein results in increased expression of DLK1 mRNA CTD PMID:24560969 NCBI chr14:100,726,892...100,738,224
Ensembl chr14:100,725,705...100,738,224
JBrowse link
G EGF epidermal growth factor multiple interactions EXP baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
decreases phosphorylation
EXP baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of EGFR protein] CTD PMID:25625231 PMID:33838155 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR2 early growth response 2 decreases expression ISO baicalein results in decreased expression of EGR2 mRNA CTD PMID:24560969 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167
JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions EXP baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604
JBrowse link
G EPO erythropoietin increases expression EXP baicalein results in increased expression of EPO mRNA CTD PMID:37348668 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
EXP baicalein results in decreased expression of and results in decreased phosphorylation of ERBB2 protein
baicalein results in decreased expression of ERBB2 mRNA
CTD PMID:36988316 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression ISO baicalein results in decreased expression of FABP4 protein CTD PMID:24560969 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FASN fatty acid synthase decreases expression ISO baicalein results in decreased expression of FASN protein CTD PMID:24560969 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FN1 fibronectin 1 multiple interactions EXP baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:30201452 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G GLB1 galactosidase beta 1 multiple interactions EXP baicalein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein] CTD PMID:34624459 NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202
JBrowse link
G GLI1 GLI family zinc finger 1 decreases expression ISO baicalein results in decreased expression of GLI1 mRNA; baicalein results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr12:57,459,785...57,472,268
Ensembl chr12:57,459,785...57,472,268
JBrowse link
G GPAT3 glycerol-3-phosphate acyltransferase 3 decreases expression ISO baicalein results in decreased expression of GPAT3 protein CTD PMID:24560969 NCBI chr 4:83,535,587...83,605,875
Ensembl chr 4:83,535,914...83,605,875
JBrowse link
G GPX4 glutathione peroxidase 4 affects expression
multiple interactions
ISO
EXP
baicalein affects the expression of GPX4 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]
CTD PMID:36055377 PMID:37354967 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
EXP baicalein results in decreased phosphorylation of GSK3B protein
baicalein inhibits the reaction [Mitomycin results in increased phosphorylation of GSK3B protein]
CTD PMID:22820424 PMID:34624459 PMID:36988316 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HES1 hes family bHLH transcription factor 1 multiple interactions
increases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA] CTD PMID:19160421 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 multiple interactions
increases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA] CTD PMID:19160421 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA] CTD PMID:19160421 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP baicalein results in increased expression of HIF1A mRNA; baicalein results in increased expression of HIF1A protein
baicalein results in decreased degradation of and results in increased expression of HIF1A protein modified form
CTD PMID:37348668 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
baicalein results in increased expression of HMOX1 mRNA; baicalein results in increased expression of HMOX1 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]
Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
CTD PMID:14563492 PMID:37354967 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases activity
EXP 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein] CTD PMID:18032417 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] CTD PMID:17458902 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein] CTD PMID:22369883 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G INS insulin multiple interactions
increases secretion
EXP baicalein promotes the reaction [Glucose results in increased secretion of INS protein]
baicalein results in increased secretion of INS protein
CTD PMID:17192482 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] CTD PMID:17458902 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KLF2 KLF transcription factor 2 increases expression ISO baicalein results in increased expression of KLF2 mRNA CTD PMID:24560969 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685
JBrowse link
G KLF5 KLF transcription factor 5 decreases expression ISO baicalein results in decreased expression of KLF5 mRNA CTD PMID:24560969 NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541
JBrowse link
G LPIN1 lipin 1 decreases expression ISO baicalein results in decreased expression of LPIN1 protein CTD PMID:24560969 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein]
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK1 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
baicalein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK3 protein]
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK3 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP baicalein results in decreased phosphorylation of and results in decreased activity of MAPK8 protein CTD PMID:10718847 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MIR1224 microRNA 1224 increases expression EXP baicalein results in increased expression of MIR1224 mRNA CTD PMID:33838155 NCBI chr 3:184,241,405...184,241,489
Ensembl chr 3:184,241,405...184,241,489
JBrowse link
G MIR21 microRNA 21 multiple interactions EXP baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] CTD PMID:30201452 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIR3195 microRNA 3195 increases expression EXP baicalein results in increased expression of MIR3195 mRNA CTD PMID:33838155 NCBI chr20:62,064,802...62,064,885
Ensembl chr20:62,064,802...62,064,885
JBrowse link
G MIR3663 microRNA 3663 multiple interactions
increases expression
increases response to substance
EXP MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of SH3GL1 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of EGFR protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK3 protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]
baicalein results in increased expression of MIR3663 mRNA
MIR3663 mRNA results in increased susceptibility to baicalein
CTD PMID:33838155 NCBI chr10:117,167,678...117,167,774
Ensembl chr10:117,167,678...117,167,774
JBrowse link
G MIR424 microRNA 424 increases expression EXP baicalein results in increased expression of MIR424 mRNA CTD PMID:33838155 NCBI chr  X:134,546,614...134,546,711
Ensembl chr  X:134,546,614...134,546,711
JBrowse link
G MIR4443 microRNA 4443 increases expression EXP baicalein results in increased expression of MIR4443 mRNA CTD PMID:33838155 NCBI chr 3:48,196,564...48,196,616
Ensembl chr 3:48,196,564...48,196,616
JBrowse link
G MIR4497 microRNA 4497 increases expression EXP baicalein results in increased expression of MIR4497 mRNA CTD PMID:33838155 NCBI chr12:109,833,348...109,833,436
Ensembl chr12:109,833,348...109,833,436
JBrowse link
G MIR4674 microRNA 4674 increases expression EXP baicalein results in increased expression of MIR4674 mRNA CTD PMID:33838155 NCBI chr 9:136,546,173...136,546,259
Ensembl chr 9:136,546,173...136,546,259
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases activity
multiple interactions
EXP
ISO
baicalein results in decreased activity of MMP2 protein
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]
CTD PMID:21803068 PMID:22369883 PMID:36988316 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases activity
EXP
ISO
baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
baicalein results in decreased activity of MMP9 protein
CTD PMID:19804834 PMID:21803068 PMID:22369883 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein] CTD PMID:27780710 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of MTOR protein CTD PMID:24560969 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G NAT1 N-acetyltransferase 1 decreases expression EXP baicalein results in decreased expression of NAT1 mRNA; baicalein results in decreased expression of NAT1 protein CTD PMID:15796204 NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases localization EXP baicalein results in decreased localization of NFKB1 protein CTD PMID:21803068 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of NFKBIA protein]
baicalein results in decreased phosphorylation of NFKBIA protein
CTD PMID:20850421 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NFKBIB NFKB inhibitor beta decreases phosphorylation EXP baicalein results in decreased phosphorylation of NFKBIB protein CTD PMID:21803068 NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893
JBrowse link
G NKILA NF-kappaB interacting lncRNA multiple interactions
increases response to substance
EXP NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]
NKILA mRNA results in increased susceptibility to baicalein
CTD PMID:29481769 NCBI chr20:57,710,183...57,712,780
Ensembl chr20:57,710,156...57,712,780
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; tin protoporphyrin IX inhibits the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
baicalein results in decreased expression of NOS2 protein
CTD PMID:14563492 PMID:20850421 PMID:22369883 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH1 notch receptor 1 increases activity
increases expression
EXP baicalein results in increased activity of NOTCH1 protein
baicalein results in increased expression of NOTCH1 mRNA
CTD PMID:19160421 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects localization EXP baicalein affects the localization of NR1I3 protein CTD PMID:25625231 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G PKM pyruvate kinase M1/2 increases activity EXP baicalein results in increased activity of PKM protein CTD PMID:25388478 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819
JBrowse link
G PLA2G2A phospholipase A2 group IIA multiple interactions ISO baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein] CTD PMID:31811862 NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416
JBrowse link
G PLAU plasminogen activator, urokinase decreases activity EXP baicalein results in decreased activity of PLAU protein CTD PMID:21803068 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions EXP baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] CTD PMID:17216584 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression ISO baicalein results in decreased expression of PPARG protein CTD PMID:24560969 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRKCA protein kinase C alpha decreases phosphorylation EXP baicalein results in decreased phosphorylation of PRKCA protein CTD PMID:21803068 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]
CTD PMID:19804834 PMID:22369883 PMID:31811862 PMID:37354967 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PYGB glycogen phosphorylase B decreases activity EXP baicalein results in decreased activity of PYGB protein CTD PMID:37277066 NCBI chr20:25,248,085...25,298,012
Ensembl chr20:25,248,085...25,298,012
JBrowse link
G PYGL glycogen phosphorylase L decreases activity EXP baicalein results in decreased activity of PYGL protein CTD PMID:37277066 NCBI chr14:50,905,217...50,944,483
Ensembl chr14:50,857,891...50,944,483
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
EXP AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein] CTD PMID:22820424 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
affects localization
decreases localization
ISO
EXP
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of RELA protein]; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
baicalein results in decreased phosphorylation of RELA protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]; NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]
baicalein results in decreased localization of RELA protein
CTD PMID:20850421 PMID:21803068 PMID:22369883 PMID:29481769 PMID:33838155 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions ISO baicalein results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein CTD PMID:24560969 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 decreases expression
multiple interactions
EXP baicalein results in decreased expression of SH3GL1 mRNA; baicalein results in decreased expression of SH3GL1 protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of SH3GL1 protein]
CTD PMID:33838155 NCBI chr19:4,360,370...4,400,547
Ensembl chr19:4,360,370...4,400,547
JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]] CTD PMID:37354967 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC22A6 solute carrier family 22 member 6 decreases activity EXP baicalein results in decreased activity of SLC22A6 protein CTD PMID:32159797 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions EXP baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]] CTD PMID:37354967 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SNCA synuclein alpha multiple interactions EXP
ISO
baicalein inhibits the reaction [SNCA protein binds to SNCA protein]
baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein]
CTD PMID:27425033 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SPRY1 sprouty RTK signaling antagonist 1 multiple interactions EXP baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] CTD PMID:30201452 NCBI chr 4:123,396,795...123,403,760
Ensembl chr 4:123,396,795...123,403,760
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases expression ISO baicalein results in decreased expression of SREBF1 protein CTD PMID:24560969 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein] CTD PMID:30201452 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO
EXP
baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD PMID:19474275 PMID:30201452 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27425033 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
ISO baicalein results in decreased expression of TNF protein
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]
CTD PMID:20850421 PMID:22369883 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP baicalein results in increased expression of TP53 protein
baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]
CTD PMID:21457722 PMID:37354967 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 decreases activity EXP baicalein results in decreased activity of UGT1A10 protein CTD PMID:33440186 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 decreases activity EXP baicalein results in decreased activity of UGT1A8 protein CTD PMID:33440186 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of baicalein CTD PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP baicalein results in decreased expression of VEGFA protein CTD PMID:16638750 PMID:36988316 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO baicalein inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein] CTD PMID:34044073 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions ISO baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein] CTD PMID:20850421 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972
JBrowse link
baicalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions
increases expression
ISO baicalin results in increased expression of and results in increased activity of ACHE protein
baicalin results in increased expression of ACHE mRNA
CTD PMID:27019979 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AHR aryl hydrocarbon receptor increases activity ISO
EXP
baicalin results in increased activity of AHR protein CTD PMID:17869316 PMID:26204831 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:38016618 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions ISO baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein] CTD PMID:20139896 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G ANGPT1 angiopoietin 1 multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in decreased expression of ANGPT1 mRNA] CTD PMID:34414639 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions ISO baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein] CTD PMID:24312512 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
baicalin results in increased expression of BAX protein
baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein]
baicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein]
baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]
CTD PMID:21457722 PMID:25423838 PMID:31021006 PMID:36446982 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO
EXP
baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein]
baicalin affects the reaction [Rotenone results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
baicalin results in decreased expression of BCL2 protein
baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
CTD PMID:25423838 PMID:31021006 PMID:36446982 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP1 caspase 1 multiple interactions ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]] CTD PMID:38016618 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP
baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein]
baicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein]
baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]
CTD PMID:25423838 PMID:31021006 PMID:36446982 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP baicalin results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCND1 cyclin D1 increases expression
decreases expression
multiple interactions
EXP baicalin results in increased expression of CCND1 mRNA
baicalin results in decreased expression of CCND1 protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]
CTD PMID:19160421 PMID:21457722 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions ISO baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
EXP 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein
CTD PMID:18451504 PMID:26204831 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases expression
EXP
ISO
3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein
CTD PMID:26204831 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G EGF epidermal growth factor multiple interactions EXP baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions EXP baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:29031535 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819
JBrowse link
G FOXA2 forkhead box A2 decreases expression EXP baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein CTD PMID:32687838 NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,580,998...22,585,455
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein] CTD PMID:15645217 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] CTD PMID:15645217 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G HES1 hes family bHLH transcription factor 1 increases expression
multiple interactions
EXP baicalin results in increased expression of HES1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]
CTD PMID:19160421 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 increases expression
multiple interactions
EXP baicalin results in increased expression of HEY1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]
CTD PMID:19160421 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression
EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA] CTD PMID:19160421 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HMOX1 protein]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]
baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein
CTD PMID:16824337 PMID:18187930 PMID:38016618 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HNF1A HNF1 homeobox A decreases expression
multiple interactions
EXP
ISO
baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]
CTD PMID:32687838 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha decreases expression
multiple interactions
ISO
EXP
baicalin results in decreased expression of HNF4A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]
baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein
CTD PMID:32687838 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein] CTD PMID:34414639 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]
baicalin inhibits the reaction [Rotenone results in increased expression of IL1B protein]
CTD PMID:29031535 PMID:36446982 PMID:38016618 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
ISO baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]
CTD PMID:22019745 PMID:29031535 PMID:38016618 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:34414639 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein] CTD PMID:38016618 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:34414639 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:34414639 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor decreases expression ISO baicalin results in decreased expression of MYD88 protein CTD PMID:22019745 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]] CTD PMID:38016618 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression ISO baicalin results in increased expression of NFKBIA protein CTD PMID:22019745 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]] CTD PMID:29031535 PMID:38016618 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
CTD PMID:18187930 PMID:22019745 PMID:24312512 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH1 notch receptor 1 increases activity
increases expression
EXP baicalin results in increased activity of NOTCH1 protein
baicalin results in increased expression of NOTCH1 mRNA
CTD PMID:19160421 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression EXP Baicalin increases expression of NR1H3 mRNA and protein in foam cells RGD PMID:27389392 RGD:401842390 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G PKM pyruvate kinase M1/2 increases activity EXP baicalin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein] CTD PMID:24312512 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRIMA1 proline rich membrane anchor 1 increases expression ISO baicalin results in increased expression of PRIMA1 mRNA CTD PMID:27019979 NCBI chr14:93,718,298...93,788,994
Ensembl chr14:93,718,298...93,788,485
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression ISO baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein CTD PMID:22019745 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]] CTD PMID:38016618 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO baicalin affects the localization of and results in decreased expression of RELA protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]
CTD PMID:22019745 PMID:38016618 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SNCA synuclein alpha multiple interactions ISO [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]] CTD PMID:38016618 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G TEK TEK receptor tyrosine kinase multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in decreased expression of TEK mRNA] CTD PMID:34414639 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions
decreases expression
EXP baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]
baicalin results in decreased expression of TFAM mRNA
CTD PMID:36446982 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in decreased expression of TGFB1 mRNA]; baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 PMID:34414639 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TH protein] CTD PMID:38016618 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TLR4 toll like receptor 4 decreases expression
multiple interactions
ISO baicalin results in decreased expression of TLR4 protein
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
CTD PMID:22019745 PMID:24312512 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
ISO baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein
baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]
CTD PMID:16824337 PMID:18187930 PMID:22019745 PMID:38016618 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 increases expression EXP baicalin results in increased expression of TP53 protein CTD PMID:21457722 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TXNIP thioredoxin interacting protein multiple interactions ISO baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]] CTD PMID:29031535 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G USP27X ubiquitin specific peptidase 27 X-linked multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in increased expression of USP27X protein] CTD PMID:34414639 NCBI chr  X:49,879,484...49,882,558
Ensembl chr  X:49,879,484...49,882,558
JBrowse link
G VEGFC vascular endothelial growth factor C multiple interactions ISO baicalin inhibits the reaction [Streptozocin results in decreased expression of VEGFC mRNA] CTD PMID:34414639 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO baicalin inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein] CTD PMID:34044073 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression EXP cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B decreases expression EXP cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 increases expression EXP cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDC25C cell division cycle 25C decreases expression EXP cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G CDC34 cell division cycle 34, ubiqiutin conjugating enzyme decreases expression EXP cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr19:531,760...542,087
Ensembl chr19:531,760...542,092
JBrowse link
G CDC45 cell division cycle 45 decreases expression EXP cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr22:19,479,466...19,520,612
Ensembl chr22:19,479,457...19,520,612
JBrowse link
G CDC6 cell division cycle 6 decreases expression EXP cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 decreases expression EXP cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:54,397,007...54,420,218
Ensembl chr14:54,396,849...54,420,218
JBrowse link
G CENPF centromere protein F decreases expression EXP cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,185...214,664,574
JBrowse link
G GDF15 growth differentiation factor 15 increases expression EXP cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G MCM2 minichromosome maintenance complex component 2 decreases expression EXP cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MCM6 minichromosome maintenance complex component 6 decreases expression EXP cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G MCM7 minichromosome maintenance complex component 7 decreases expression EXP cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,233...100,101,940
JBrowse link
G MCM8 minichromosome maintenance 8 homologous recombination repair factor decreases expression EXP cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr20:5,950,652...5,998,977
Ensembl chr20:5,950,652...5,998,977
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MYT1 myelin transcription factor 1 decreases expression EXP cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr20:64,164,452...64,242,253
Ensembl chr20:64,102,394...64,242,253
JBrowse link
G NEK2 NIMA related kinase 2 decreases expression EXP cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:211,658,256...211,675,621
Ensembl chr 1:211,658,657...211,675,630
JBrowse link
G TP53 tumor protein p53 increases expression
increases activity
EXP cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein
CTD PMID:16120219 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TTK TTK protein kinase decreases expression EXP cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 6:80,004,649...80,042,527
Ensembl chr 6:80,003,887...80,042,527
JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 multiple interactions EXP ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] CTD PMID:17018608 NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445
JBrowse link
G AFP alpha fetoprotein multiple interactions ISO ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA] CTD PMID:11133813 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions
decreases activity
ISO Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]
ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]
CTD PMID:14630126 PMID:17624921 PMID:23933410 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP ebselen results in decreased activity of ALOX5 protein CTD PMID:7590103 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:30558456 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] CTD PMID:30558456 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP
ISO
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
ebselen results in increased activity of CASP3 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
CTD PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions EXP
ISO
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]
ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]
CTD PMID:18629305 PMID:23649643 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase increases activity
multiple interactions
ISO ebselen results in increased activity of CAT protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:27282967 PMID:30558456 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 increases expression EXP ebselen results in increased expression of COX4I1 protein CTD PMID:27385396 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
JBrowse link
G CS citrate synthase multiple interactions EXP
ISO
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]
ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein]
CTD PMID:27385396 PMID:32860823 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP ebselen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 protein] CTD PMID:14572605 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] CTD PMID:11903743 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO ebselen results in increased phosphorylation of EIF2S1 protein CTD PMID:27282967 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions EXP ebselen binds to and results in decreased activity of EPHX2 protein CTD PMID:23219563 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 multiple interactions EXP ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] CTD PMID:27385396 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein] CTD PMID:32860823 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G GCK glucokinase multiple interactions ISO [ebselen co-treated with Glucose] results in increased activity of GCK protein CTD PMID:23795780 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GFAP glial fibrillary acidic protein increases phosphorylation ISO ebselen results in increased phosphorylation of GFAP protein CTD PMID:27282967 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein] CTD PMID:12958040 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO
EXP
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein]
CTD PMID:23795780 PMID:28383113 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GSR glutathione-disulfide reductase increases activity
multiple interactions
ISO ebselen results in increased activity of GSR protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
CTD PMID:27282967 PMID:30558456 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions ISO ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein] CTD PMID:8147899 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions ISO ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] CTD PMID:8147899 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions ISO ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] CTD PMID:8147899 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions ISO ebselen binds to and results in decreased activity of GSTP1 protein CTD PMID:8147899 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]] CTD PMID:19374849 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO [ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein CTD PMID:16959961 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HPGDS hematopoietic prostaglandin D synthase increases expression ISO ebselen results in increased expression of HPGDS mRNA CTD PMID:21669866 NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876
JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP ebselen results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G IFNG interferon gamma multiple interactions ISO ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12794164 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL6 interleukin 6 multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:30558456 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:23795780 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases activity
increases phosphorylation
ISO ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen results in increased activity of MAPK1 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein
CTD PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases activity
increases phosphorylation
ISO ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen results in increased activity of MAPK3 protein
ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation ISO ebselen results in increased phosphorylation of MAPK9 protein CTD PMID:27282967 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] CTD PMID:11903743 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G NGF nerve growth factor multiple interactions ISO ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20495008 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases activity
ISO ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
ebselen results in decreased activity of NOS2 protein
CTD PMID:7590103 PMID:12794164 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases activity ISO ebselen results in decreased activity of NQO1 protein CTD PMID:7590103 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 multiple interactions ISO [ebselen co-treated with Glucose] results in increased expression of PDX1 protein CTD PMID:23795780 NCBI chr13:27,920,000...27,926,313
Ensembl chr13:27,920,000...27,926,313
JBrowse link
G PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase 1 decreases activity EXP ebselen results in decreased activity of PHOSPHO1 protein CTD PMID:17227223 NCBI chr17:49,223,366...49,230,787
Ensembl chr17:49,223,366...49,230,787
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] CTD PMID:14572605 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SLC11A2 solute carrier family 11 member 2 multiple interactions EXP ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] CTD PMID:16984886 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566
JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO [ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein
ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein]
CTD PMID:23795780 PMID:32860823 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions EXP ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
JBrowse link
G SOD1 superoxide dismutase 1 decreases response to substance
multiple interactions
EXP
ISO
ebselen results in decreased susceptibility to SOD1 protein mutant form
ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
CTD PMID:16702190 PMID:23795780 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20495008 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TAT tyrosine aminotransferase multiple interactions ISO ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein] CTD PMID:32860823 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO
EXP
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD PMID:11903743 PMID:16757516 PMID:21131394 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:11903743 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein] CTD PMID:30558456 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions EXP ebselen results in increased expression of and results in increased activity of TXNRD1 protein CTD PMID:28383113 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO [ebselen co-treated with Glucose] results in decreased expression of UCP2 protein CTD PMID:23795780 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G XBP1 X-box binding protein 1 increases phosphorylation ISO ebselen results in increased phosphorylation of XBP1 protein CTD PMID:27282967 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
G XPA XPA, DNA damage recognition and repair factor multiple interactions EXP ebselen inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 9:97,654,398...97,697,340
Ensembl chr 9:97,674,909...97,697,340
JBrowse link
geldanamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP geldanamycin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA] CTD PMID:37586545 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression EXP geldanamycin results in increased expression of ACAP2 mRNA CTD PMID:26705709 NCBI chr 3:195,274,745...195,443,020
Ensembl chr 3:195,274,745...195,443,044
JBrowse link
G ACTR2 actin related protein 2 increases expression EXP geldanamycin results in increased expression of ACTR2 mRNA CTD PMID:26705709 NCBI chr 2:65,227,831...65,271,253
Ensembl chr 2:65,227,788...65,271,253
JBrowse link
G AFF3 ALF transcription elongation factor 3 increases expression EXP geldanamycin results in increased expression of AFF3 mRNA CTD PMID:26705709 NCBI chr 2:99,545,419...100,142,590
Ensembl chr 2:99,545,419...100,192,428
JBrowse link
G AFF4 ALF transcription elongation factor 4 increases expression EXP geldanamycin results in increased expression of AFF4 mRNA CTD PMID:26705709 NCBI chr 5:132,875,395...132,963,634
Ensembl chr 5:132,875,395...132,963,634
JBrowse link
G AGFG1 ArfGAP with FG repeats 1 increases expression EXP geldanamycin results in increased expression of AGFG1 mRNA CTD PMID:26705709 NCBI chr 2:227,472,156...227,561,217
Ensembl chr 2:227,472,152...227,561,217
JBrowse link
G AHR aryl hydrocarbon receptor increases localization
decreases expression
increases degradation
multiple interactions
EXP
ISO
geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
CTD PMID:9664232 PMID:12237327 PMID:12606767 PMID:16226227 PMID:20057149 More... NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein
CTD PMID:15781649 PMID:17293044 PMID:19167484 PMID:24211270 PMID:24450340 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT3 AKT serine/threonine kinase 3 increases expression EXP geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 NCBI chr 1:243,488,233...243,851,079
Ensembl chr 1:243,488,233...243,851,079
JBrowse link
G AMOTL1 angiomotin like 1 increases expression EXP geldanamycin results in increased expression of AMOTL1 mRNA CTD PMID:26705709 NCBI chr11:94,706,460...94,876,748
Ensembl chr11:94,706,431...94,876,748
JBrowse link
G ANGPT1 angiopoietin 1 increases expression EXP geldanamycin results in increased expression of ANGPT1 mRNA CTD PMID:26705709 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G ANGPTL1 angiopoietin like 1 decreases expression EXP geldanamycin results in decreased expression of ANGPTL1 mRNA CTD PMID:26705709 NCBI chr 1:178,849,535...178,871,077
Ensembl chr 1:178,849,535...178,871,077
JBrowse link
G ANKRD1 ankyrin repeat domain 1 increases expression EXP geldanamycin results in increased expression of ANKRD1 mRNA CTD PMID:26705709 NCBI chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087
JBrowse link
G AP5M1 adaptor related protein complex 5 subunit mu 1 increases expression EXP geldanamycin results in increased expression of AP5M1 mRNA CTD PMID:26705709 NCBI chr14:57,268,971...57,298,742
Ensembl chr14:57,268,924...57,298,742
JBrowse link
G APELA apelin receptor early endogenous ligand increases expression EXP geldanamycin results in increased expression of APELA mRNA CTD PMID:26705709 NCBI chr 4:164,877,178...164,899,007
Ensembl chr 4:164,877,178...164,898,965
JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 increases expression EXP geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 NCBI chr12:105,173,300...105,236,174
Ensembl chr12:105,173,297...105,236,203
JBrowse link
G ARB2A ARB2 cotranscriptional regulator A increases expression EXP geldanamycin results in increased expression of ARB2A mRNA CTD PMID:26705709 NCBI chr 5:93,617,725...94,111,699
Ensembl chr 5:93,617,725...94,111,699
JBrowse link
G ARFIP1 ADP ribosylation factor interacting protein 1 increases expression EXP geldanamycin results in increased expression of ARFIP1 mRNA CTD PMID:26705709 NCBI chr 4:152,779,954...152,912,357
Ensembl chr 4:152,779,937...152,918,463
JBrowse link
G ASPM assembly factor for spindle microtubules increases expression EXP geldanamycin results in increased expression of ASPM mRNA CTD PMID:26705709 NCBI chr 1:197,084,127...197,146,669
Ensembl chr 1:197,084,121...197,146,694
JBrowse link
G ATP11B ATPase phospholipid transporting 11B (putative) increases expression EXP geldanamycin results in increased expression of ATP11B mRNA CTD PMID:26705709 NCBI chr 3:182,793,504...182,921,629
Ensembl chr 3:182,793,503...182,921,629
JBrowse link
G ATP11C ATPase phospholipid transporting 11C increases expression EXP geldanamycin results in increased expression of ATP11C mRNA CTD PMID:26705709 NCBI chr  X:139,726,348...139,936,903
Ensembl chr  X:139,726,346...139,945,276
JBrowse link
G ATP13A3 ATPase 13A3 increases expression EXP geldanamycin results in increased expression of ATP13A3 mRNA CTD PMID:26705709 NCBI chr 3:194,402,677...194,494,334
Ensembl chr 3:194,402,672...194,498,364
JBrowse link
G ATP13A5 ATPase 13A5 increases expression EXP geldanamycin results in increased expression of ATP13A5 mRNA CTD PMID:26705709 NCBI chr 3:193,274,789...193,378,753
Ensembl chr 3:193,274,789...193,378,820
JBrowse link
G ATRX ATRX chromatin remodeler increases expression EXP geldanamycin results in increased expression of ATRX mRNA CTD PMID:26705709 NCBI chr  X:77,504,880...77,786,216
Ensembl chr  X:77,504,880...77,786,233
JBrowse link
G ATXN7L3B ataxin 7 like 3B increases expression EXP geldanamycin results in increased expression of ATXN7L3B mRNA CTD PMID:26705709 NCBI chr12:74,537,835...74,545,430
Ensembl chr12:74,537,835...74,545,430
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein; geldanamycin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
geldanamycin results in decreased expression of BCL2 protein
CTD PMID:15781649 PMID:28673683 PMID:37586545 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases response to substance
multiple interactions
EXP BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein
CTD PMID:15781649 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCOR BCL6 corepressor increases expression EXP geldanamycin results in increased expression of BCOR mRNA CTD PMID:26705709 NCBI chr  X:40,051,246...40,177,329
Ensembl chr  X:40,049,815...40,177,329
JBrowse link
G BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression EXP geldanamycin results in increased expression of BDP1 mRNA CTD PMID:26705709 NCBI chr 5:71,455,651...71,578,288
Ensembl chr 5:71,455,651...71,567,820
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein CTD PMID:15781649 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BLTP2 bridge-like lipid transfer protein family member 2 increases expression EXP geldanamycin results in increased expression of BLTP2 mRNA CTD PMID:26705709 NCBI chr17:28,614,440...28,645,159
Ensembl chr17:28,614,446...28,645,454
JBrowse link
G BOD1L1 biorientation of chromosomes in cell division 1 like 1 increases expression EXP geldanamycin results in increased expression of BOD1L1 mRNA CTD PMID:26705709 NCBI chr 4:13,568,738...13,627,725
Ensembl chr 4:13,568,738...13,627,725
JBrowse link
G C5orf22 chromosome 5 open reading frame 22 increases expression EXP geldanamycin results in increased expression of C5ORF22 mRNA CTD PMID:26705709 NCBI chr 5:31,532,301...31,555,053
Ensembl chr 5:31,532,287...31,555,053
JBrowse link
G C5orf24 chromosome 5 open reading frame 24 increases expression EXP geldanamycin results in increased expression of C5ORF24 mRNA CTD PMID:26705709 NCBI chr 5:134,833,602...134,859,735
Ensembl chr 5:134,845,680...134,859,735
JBrowse link
G CAB39 calcium binding protein 39 increases expression EXP geldanamycin results in increased expression of CAB39 mRNA CTD PMID:26705709 NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075
JBrowse link
G CALD1 caldesmon 1 increases expression EXP geldanamycin results in increased expression of CALD1 mRNA CTD PMID:26705709 NCBI chr 7:134,745,467...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CASK calcium/calmodulin dependent serine protein kinase increases expression EXP geldanamycin results in increased expression of CASK mRNA CTD PMID:26705709 NCBI chr  X:41,514,934...41,923,554
Ensembl chr  X:41,514,934...41,923,554
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] CTD PMID:12115584 PMID:12530016 PMID:14576064 PMID:24998639 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein] CTD PMID:24998639 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 multiple interactions EXP geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] CTD PMID:16311509 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CBL Cbl proto-oncogene increases expression EXP geldanamycin results in increased expression of CBL mRNA CTD PMID:26705709 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
JBrowse link
G CCDC186 coiled-coil domain containing 186 increases expression EXP geldanamycin results in increased expression of CCDC186 mRNA CTD PMID:26705709 NCBI chr10:114,120,862...114,174,220
Ensembl chr10:114,120,862...114,174,232
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein
CTD PMID:15781649 PMID:17959518 PMID:24211270 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 increases expression EXP geldanamycin results in increased expression of CCND2 mRNA CTD PMID:26705709 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCNE2 cyclin E2 increases expression EXP geldanamycin results in increased expression of CCNE2 mRNA CTD PMID:26705709 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CCNK cyclin K increases expression EXP geldanamycin results in increased expression of CCNK mRNA CTD PMID:26705709 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
JBrowse link
G CDC27 cell division cycle 27 increases expression EXP geldanamycin results in increased expression of CDC27 mRNA CTD PMID:26705709 NCBI chr17:47,117,703...47,189,295
Ensembl chr17:47,117,703...47,189,422
JBrowse link
G CDC37 cell division cycle 37, HSP90 cochaperone multiple interactions EXP geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] CTD PMID:17223712 NCBI chr19:10,391,133...10,403,542
Ensembl chr19:10,391,133...10,420,121
JBrowse link
G CDCA2 cell division cycle associated 2 increases expression EXP geldanamycin results in increased expression of CDCA2 mRNA CTD PMID:26705709 NCBI chr 8:25,458,931...25,507,917
Ensembl chr 8:25,459,199...25,507,911
JBrowse link
G CDH1 cadherin 1 multiple interactions
increases expression
EXP geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDH4 cadherin 4 increases expression EXP geldanamycin results in increased expression of CDH4 mRNA CTD PMID:26705709 NCBI chr20:61,252,261...61,940,617
Ensembl chr20:61,252,261...61,940,617
JBrowse link
G CDK13 cyclin dependent kinase 13 increases expression EXP geldanamycin results in increased expression of CDK13 mRNA CTD PMID:26705709 NCBI chr 7:39,950,256...40,099,580
Ensembl chr 7:39,950,121...40,099,580
JBrowse link
G CDK14 cyclin dependent kinase 14 increases expression EXP geldanamycin results in increased expression of CDK14 mRNA CTD PMID:26705709 NCBI chr 7:90,596,321...91,210,590
Ensembl chr 7:90,466,424...91,210,590
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 increases expression EXP geldanamycin results in increased expression of CDK6 mRNA CTD PMID:26705709 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CENPJ centromere protein J increases expression EXP geldanamycin results in increased expression of CENPJ mRNA CTD PMID:26705709 NCBI chr13:24,882,279...24,934,000
Ensembl chr13:24,882,279...24,922,889
JBrowse link
G CEP89 centrosomal protein 89 increases expression EXP geldanamycin results in increased expression of CEP89 mRNA CTD PMID:26705709 NCBI chr19:32,875,925...32,971,958
Ensembl chr19:32,875,925...32,971,991
JBrowse link
G CEP95 centrosomal protein 95 increases expression EXP geldanamycin results in increased expression of CEP95 mRNA CTD PMID:26705709 NCBI chr17:64,506,762...64,537,946
Ensembl chr17:64,506,865...64,542,461
JBrowse link
G CERS6 ceramide synthase 6 increases expression EXP geldanamycin results in increased expression of CERS6 mRNA CTD PMID:26705709 NCBI chr 2:168,456,272...168,775,134
Ensembl chr 2:168,456,249...168,775,134
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex increases degradation EXP geldanamycin results in increased degradation of CHUK protein CTD PMID:15930313 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CLIP1 CAP-Gly domain containing linker protein 1 increases expression EXP geldanamycin results in increased expression of CLIP1 mRNA CTD PMID:26705709 NCBI chr12:122,271,469...122,422,956
Ensembl chr12:122,271,432...122,422,669
JBrowse link
G CLK4 CDC like kinase 4 increases expression EXP geldanamycin results in increased expression of CLK4 mRNA CTD PMID:26705709 NCBI chr 5:178,602,664...178,627,050
Ensembl chr 5:178,602,664...178,630,615
JBrowse link
G COL12A1 collagen type XII alpha 1 chain increases expression EXP geldanamycin results in increased expression of COL12A1 mRNA CTD PMID:26705709 NCBI chr 6:75,084,326...75,206,053
Ensembl chr 6:75,084,326...75,206,267
JBrowse link
G COL25A1 collagen type XXV alpha 1 chain increases expression EXP geldanamycin results in increased expression of COL25A1 mRNA CTD PMID:26705709 NCBI chr 4:108,808,725...109,302,658
Ensembl chr 4:108,808,725...109,302,752
JBrowse link
G COL8A1 collagen type VIII alpha 1 chain increases expression EXP geldanamycin results in increased expression of COL8A1 mRNA CTD PMID:26705709 NCBI chr 3:99,638,594...99,799,217
Ensembl chr 3:99,638,475...99,799,226
JBrowse link
G CPNE3 copine 3 increases expression EXP geldanamycin results in increased expression of CPNE3 mRNA CTD PMID:26705709 NCBI chr 8:86,514,435...86,561,498
Ensembl chr 8:86,514,435...86,561,498
JBrowse link
G CRCP CGRP receptor component increases expression EXP geldanamycin results in increased expression of CRCP mRNA CTD PMID:26705709 NCBI chr 7:66,114,818...66,154,568
Ensembl chr 7:66,114,604...66,154,568
JBrowse link
G CSK C-terminal Src kinase multiple interactions
decreases activity
ISO geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein
CTD PMID:9664232 NCBI chr15:74,782,080...74,803,197
Ensembl chr15:74,782,080...74,803,197
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 increases expression EXP geldanamycin results in increased expression of CSNK2A1 mRNA CTD PMID:26705709 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
JBrowse link
G CTDSPL2 CTD small phosphatase like 2 increases expression EXP geldanamycin results in increased expression of CTDSPL2 mRNA CTD PMID:26705709 NCBI chr15:44,427,629...44,529,038
Ensembl chr15:44,427,622...44,529,038
JBrowse link
G CTNNA1 catenin alpha 1 increases expression EXP geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] CTD PMID:17024233 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CUL5 cullin 5 increases expression EXP geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 NCBI chr11:108,008,898...108,107,761
Ensembl chr11:108,008,898...108,107,761
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein] CTD PMID:11472980 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO geldanamycin results in increased expression of CYP17A1 mRNA CTD PMID:15711029 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO
EXP
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:12237327 PMID:20057149 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 increases expression EXP geldanamycin results in increased expression of DDR2 mRNA CTD PMID:26705709 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405
JBrowse link
G DDX17 DEAD-box helicase 17 increases expression EXP geldanamycin results in increased expression of DDX17 mRNA CTD PMID:26705709 NCBI chr22:38,483,438...38,506,311
Ensembl chr22:38,483,438...38,507,660
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked increases expression
increases degradation
EXP geldanamycin results in increased expression of DDX3X mRNA
geldanamycin results in increased degradation of DDX3X protein
CTD PMID:26705709 PMID:30821613 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472
JBrowse link
G DDX42 DEAD-box helicase 42 increases expression EXP geldanamycin results in increased expression of DDX42 mRNA CTD PMID:26705709 NCBI chr17:63,773,800...63,819,317
Ensembl chr17:63,773,603...63,819,317
JBrowse link
G DDX6 DEAD-box helicase 6 increases expression EXP geldanamycin results in increased expression of DDX6 mRNA CTD PMID:26705709 NCBI chr11:118,747,763...118,791,744
Ensembl chr11:118,747,763...118,791,164
JBrowse link
G DHX9 DExH-box helicase 9 increases expression EXP geldanamycin results in increased expression of DHX9 mRNA CTD PMID:26705709 NCBI chr 1:182,839,347...182,887,982
Ensembl chr 1:182,839,347...182,887,982
JBrowse link
G DIP2A disco interacting protein 2 homolog A increases expression EXP geldanamycin results in increased expression of DIP2A mRNA CTD PMID:26705709 NCBI chr21:46,458,891...46,583,871
Ensembl chr21:46,458,891...46,570,015
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 increases expression EXP geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
JBrowse link
G DMD dystrophin increases expression EXP geldanamycin results in increased expression of DMD mRNA CTD PMID:26705709 NCBI chr  X:31,119,222...33,339,388
Ensembl chr  X:31,097,677...33,339,609
JBrowse link
G DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 increases expression EXP geldanamycin results in increased expression of DNAJC13 mRNA CTD PMID:26705709 NCBI chr 3:132,417,502...132,539,032
Ensembl chr 3:132,417,502...132,539,032
JBrowse link
G DST dystonin increases expression EXP geldanamycin results in increased expression of DST mRNA CTD PMID:26705709 NCBI chr 6:56,457,996...56,954,830
Ensembl chr 6:56,457,987...56,954,830
JBrowse link
G E2F3 E2F transcription factor 3 increases expression EXP geldanamycin results in increased expression of E2F3 mRNA CTD PMID:26705709 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714
JBrowse link
G EDIL3 EGF like repeats and discoidin domains 3 increases expression EXP geldanamycin results in increased expression of EDIL3 mRNA CTD PMID:26705709 NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880
JBrowse link
G EDN1 endothelin 1 increases expression EXP geldanamycin results in increased expression of EDN1 mRNA CTD PMID:26705709 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EEA1 early endosome antigen 1 increases expression EXP geldanamycin results in increased expression of EEA1 mRNA CTD PMID:26705709 NCBI chr12:92,770,637...92,929,295
Ensembl chr12:92,770,637...92,929,331
JBrowse link
G EGF epidermal growth factor multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 PMID:9664232 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
decreases expression
EXP
ISO
geldanamycin inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein
CTD PMID:9605431 PMID:9664232 PMID:20007406 PMID:37586545 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EHBP1 EH domain binding protein 1 increases expression EXP geldanamycin results in increased expression of EHBP1 mRNA CTD PMID:26705709 NCBI chr 2:62,673,878...63,046,487
Ensembl chr 2:62,673,851...63,046,487
JBrowse link
G EHMT1 euchromatic histone lysine methyltransferase 1 increases expression EXP geldanamycin results in increased expression of EHMT1 mRNA CTD PMID:26705709 NCBI chr 9:137,619,005...137,836,127
Ensembl chr 9:137,618,992...137,870,016
JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 increases degradation EXP geldanamycin results in increased degradation of EIF4A1 protein CTD PMID:30821613 NCBI chr17:7,572,825...7,579,006
Ensembl chr17:7,572,824...7,579,006
JBrowse link
G ELL2 elongation factor for RNA polymerase II 2 increases expression EXP geldanamycin results in increased expression of ELL2 mRNA CTD PMID:26705709 NCBI chr 5:95,885,098...95,961,851
Ensembl chr 5:95,885,098...95,961,851
JBrowse link
G EPB41L5 erythrocyte membrane protein band 4.1 like 5 increases expression EXP geldanamycin results in increased expression of EPB41L5 mRNA CTD PMID:26705709 NCBI chr 2:120,013,077...120,179,119
Ensembl chr 2:120,013,077...120,179,119
JBrowse link
G EPRS1 glutamyl-prolyl-tRNA synthetase 1 increases expression EXP geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 NCBI chr 1:219,968,600...220,046,505
Ensembl chr 1:219,968,600...220,046,530
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 increases degradation
multiple interactions
decreases expression
EXP geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein
CTD PMID:8617772 PMID:11071886 PMID:17959518 PMID:18655187 PMID:24450340 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERCC6L2 ERCC excision repair 6 like 2 increases expression EXP geldanamycin results in increased expression of ERCC6L2 mRNA CTD PMID:26705709 NCBI chr 9:95,875,691...96,041,092
Ensembl chr 9:95,871,264...96,121,154
JBrowse link
G ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression EXP geldanamycin results in increased expression of ESCO1 mRNA CTD PMID:26705709 NCBI chr18:21,529,284...21,600,704
Ensembl chr18:21,529,284...21,600,884
JBrowse link
G ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP geldanamycin results in increased expression of ESCO2 mRNA CTD PMID:26705709 NCBI chr 8:27,771,974...27,819,660
Ensembl chr 8:27,771,949...27,812,640
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
decreases stability
increases degradation
EXP geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein
CTD PMID:11448926 PMID:16037132 PMID:24211270 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ETS1 ETS proto-oncogene 1, transcription factor increases expression EXP geldanamycin results in increased expression of ETS1 mRNA CTD PMID:26705709 NCBI chr11:128,458,765...128,587,558
Ensembl chr11:128,458,761...128,587,558
JBrowse link
G EVI5 ecotropic viral integration site 5 increases expression EXP geldanamycin results in increased expression of EVI5 mRNA CTD PMID:26705709 NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404
JBrowse link
G FAM111B FAM111 trypsin like peptidase B increases expression EXP geldanamycin results in increased expression of FAM111B mRNA CTD PMID:26705709 NCBI chr11:59,107,237...59,127,412
Ensembl chr11:59,107,185...59,127,412
JBrowse link
G FANCB FA complementation group B increases expression EXP geldanamycin results in increased expression of FANCB mRNA CTD PMID:26705709 NCBI chr  X:14,689,524...14,873,069
Ensembl chr  X:14,690,388...14,873,255
JBrowse link
G FANCM FA complementation group M increases expression EXP geldanamycin results in increased expression of FANCM mRNA CTD PMID:26705709 NCBI chr14:45,135,930...45,200,890
Ensembl chr14:45,135,930...45,200,890
JBrowse link
G FBN1 fibrillin 1 increases expression EXP geldanamycin results in increased expression of FBN1 mRNA CTD PMID:26705709 NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,313...48,645,721
JBrowse link
G FGF7 fibroblast growth factor 7 multiple interactions EXP
ISO
geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] CTD PMID:14656992 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 increases expression EXP geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FN1 fibronectin 1 increases expression EXP geldanamycin results in increased expression of FN1 mRNA CTD PMID:26705709 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FRYL FRY like transcription coactivator increases expression EXP geldanamycin results in increased expression of FRYL mRNA CTD PMID:26705709 NCBI chr 4:48,497,357...48,780,279
Ensembl chr 4:48,497,357...48,780,322
JBrowse link
G G3BP1 G3BP stress granule assembly factor 1 increases expression EXP geldanamycin results in increased expression of G3BP1 mRNA CTD PMID:26705709 NCBI chr 5:151,771,954...151,812,785
Ensembl chr 5:151,771,045...151,812,911
JBrowse link
G GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression EXP geldanamycin results in increased expression of GALNT5 mRNA CTD PMID:26705709 NCBI chr 2:157,257,705...157,318,491
Ensembl chr 2:157,257,705...157,318,491
JBrowse link
G GLS glutaminase increases expression EXP geldanamycin results in increased expression of GLS mRNA CTD PMID:26705709 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G GNG12 G protein subunit gamma 12 increases expression EXP geldanamycin results in increased expression of GNG12 mRNA CTD PMID:26705709 NCBI chr 1:67,701,475...67,833,467
Ensembl chr 1:67,701,475...67,833,467
JBrowse link
G GOLIM4 golgi integral membrane protein 4 increases expression EXP geldanamycin results in increased expression of GOLIM4 mRNA CTD PMID:26705709 NCBI chr 3:168,008,689...168,095,924
Ensembl chr 3:168,008,689...168,095,924
JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP geldanamycin results in increased expression of GRIA3 mRNA CTD PMID:26705709 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915
JBrowse link
G GTF2A1 general transcription factor IIA subunit 1 increases expression EXP geldanamycin results in increased expression of GTF2A1 mRNA CTD PMID:26705709 NCBI chr14:81,175,452...81,221,390
Ensembl chr14:81,175,452...81,221,377
JBrowse link
G H1-3 H1.3 linker histone, cluster member increases expression EXP geldanamycin results in increased expression of H1-3 mRNA CTD PMID:26705709 NCBI chr 6:26,234,212...26,234,987
Ensembl chr 6:26,234,212...26,234,987
JBrowse link
G HACD2 3-hydroxyacyl-CoA dehydratase 2 increases expression EXP geldanamycin results in increased expression of HACD2 mRNA CTD PMID:26705709 NCBI chr 3:123,491,554...123,585,053
Ensembl chr 3:123,490,820...123,585,053
JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 increases expression EXP geldanamycin results in increased expression of HCN1 mRNA CTD PMID:26705709 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498
JBrowse link
G HEATR1 HEAT repeat containing 1 increases expression EXP geldanamycin results in increased expression of HEATR1 mRNA CTD PMID:26705709 NCBI chr 1:236,549,005...236,604,516
Ensembl chr 1:236,549,005...236,604,516
JBrowse link
G HECTD1 HECT domain E3 ubiquitin protein ligase 1 increases expression EXP geldanamycin results in increased expression of HECTD1 mRNA CTD PMID:26705709 NCBI chr14:31,100,117...31,207,793
Ensembl chr14:31,100,117...31,207,804
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases degradation
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of HIF1A mRNA]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein
CTD PMID:11980636 PMID:12811834 PMID:14726529 PMID:15319539 PMID:16432534 More... NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein] CTD PMID:25645596 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase multiple interactions EXP geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] CTD PMID:15680906 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154
JBrowse link
G HSF1 heat shock transcription factor 1 multiple interactions EXP geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574 PMID:25645596 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 affects binding
multiple interactions
ISO
EXP
geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]
CTD PMID:12775586 PMID:17223712 PMID:18655187 PMID:21749116 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 affects binding
increases expression
ISO
EXP
geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA
CTD PMID:21749116 PMID:26705709 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 affects binding
multiple interactions
EXP geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]
CTD PMID:8617772 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,931
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO
EXP
geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins
CTD PMID:11448926 PMID:19723345 PMID:25477506 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
EXP geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 PMID:26705709 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
affects expression
EXP Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein
CTD PMID:14576064 PMID:15141013 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP geldanamycin results in increased expression of HSPD1 mRNA CTD PMID:26705709 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G HTT huntingtin multiple interactions EXP geldanamycin inhibits the reaction [HTT protein binds to HTT protein] CTD PMID:11406612 NCBI chr 4:3,074,681...3,243,960
Ensembl chr 4:3,041,363...3,243,957
JBrowse link
G HYCC1 hyccin PI4KA lipid kinase complex subunit 1 increases expression EXP geldanamycin results in increased expression of HYCC1 mRNA CTD PMID:26705709 NCBI chr 7:22,895,843...23,014,130
Ensembl chr 7:22,889,371...23,014,130
JBrowse link
G ICE2 interactor of little elongation complex ELL subunit 2 increases expression EXP geldanamycin results in increased expression of ICE2 mRNA CTD PMID:26705709 NCBI chr15:60,419,609...60,479,142
Ensembl chr15:60,419,609...60,479,160
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]
CTD PMID:12571865 PMID:15808840 PMID:37586545 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL24 interleukin 24 multiple interactions EXP IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139
JBrowse link
G IL6 interleukin 6 multiple interactions ISO geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] CTD PMID:12571865 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer increases expression EXP geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022
JBrowse link
G INHBA inhibin subunit beta A increases expression EXP geldanamycin results in increased expression of INHBA mRNA CTD PMID:26705709 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G INPP5A inositol polyphosphate-5-phosphatase A increases expression EXP geldanamycin results in increased expression of INPP5A mRNA CTD PMID:26705709 NCBI chr10:132,537,787...132,783,480
Ensembl chr10:132,537,787...132,783,480
JBrowse link
G IPO8 importin 8 increases expression EXP geldanamycin results in increased expression of IPO8 mRNA CTD PMID:26705709 NCBI chr12:30,628,988...30,695,869
Ensembl chr12:30,628,988...30,695,869
JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 increases expression EXP geldanamycin results in increased expression of IQGAP1 mRNA CTD PMID:26705709 NCBI chr15:90,388,242...90,502,239
Ensembl chr15:90,388,242...90,502,239
JBrowse link
G ITGA1 integrin subunit alpha 1 increases expression EXP geldanamycin results in increased expression of ITGA1 mRNA CTD PMID:26705709 NCBI chr 5:52,787,916...52,959,209
Ensembl chr 5:52,787,916...52,959,209
JBrowse link
G ITGB3 integrin subunit beta 3 increases expression EXP geldanamycin results in increased expression of ITGB3 mRNA CTD PMID:26705709 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743
JBrowse link
G ITPRID2 ITPR interacting domain containing 2 increases expression EXP geldanamycin results in increased expression of SSFA2 mRNA CTD PMID:26705709 NCBI chr 2:181,891,730...181,930,738
Ensembl chr 2:181,891,730...181,930,738
JBrowse link
G JMJD1C jumonji domain containing 1C increases expression EXP geldanamycin results in increased expression of JMJD1C mRNA CTD PMID:26705709 NCBI chr10:63,167,225...63,521,890
Ensembl chr10:63,167,221...63,521,850
JBrowse link
G KAT6A lysine acetyltransferase 6A increases expression EXP geldanamycin results in increased expression of KAT6A mRNA CTD PMID:26705709 NCBI chr 8:41,929,479...42,051,987
Ensembl chr 8:41,929,479...42,051,994
JBrowse link
G KBTBD2 kelch repeat and BTB domain containing 2 increases expression EXP geldanamycin results in increased expression of KBTBD2 mRNA CTD PMID:26705709 NCBI chr 7:32,868,172...32,892,166
Ensembl chr 7:32,868,172...32,894,131
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 affects localization
decreases activity
increases degradation
multiple interactions
decreases expression
EXP geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586 PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KDM6A lysine demethylase 6A increases expression EXP geldanamycin results in increased expression of KDM6A mRNA CTD PMID:26705709 NCBI chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
JBrowse link
G KIRREL1 kirre like nephrin family adhesion molecule 1 increases expression EXP geldanamycin results in increased expression of KIRREL1 mRNA CTD PMID:26705709 NCBI chr 1:157,993,645...158,100,262
Ensembl chr 1:157,993,273...158,100,262
JBrowse link
G KLF12 KLF transcription factor 12 increases expression EXP geldanamycin results in increased expression of KLF12 mRNA CTD PMID:26705709 NCBI chr13:73,686,089...74,306,045
Ensembl chr13:73,686,089...74,134,404
JBrowse link
G KLHL24 kelch like family member 24 increases expression EXP geldanamycin results in increased expression of KLHL24 mRNA CTD PMID:26705709 NCBI chr 3:183,635,623...183,684,519
Ensembl chr 3:183,635,610...183,684,519
JBrowse link
G KMT2A lysine methyltransferase 2A increases expression EXP geldanamycin results in increased expression of KMT2A mRNA CTD PMID:26705709 NCBI chr11:118,436,492...118,526,832
Ensembl chr11:118,436,456...118,526,832
JBrowse link
G KNL1 kinetochore scaffold 1 increases expression EXP geldanamycin results in increased expression of KNL1 mRNA CTD PMID:26705709 NCBI chr15:40,594,249...40,664,342
Ensembl chr15:40,594,020...40,664,342
JBrowse link
G LAMA4 laminin subunit alpha 4 increases expression EXP geldanamycin results in increased expression of LAMA4 mRNA CTD PMID:26705709 NCBI chr 6:112,107,931...112,254,985
Ensembl chr 6:112,107,931...112,254,939
JBrowse link
G LARP1B La ribonucleoprotein 1B increases expression EXP geldanamycin results in increased expression of LARP1B mRNA CTD PMID:26705709 NCBI chr 4:128,060,789...128,222,926
Ensembl chr 4:128,061,286...128,222,931
JBrowse link
G LARP4 La ribonucleoprotein 4 increases expression EXP geldanamycin results in increased expression of LARP4 mRNA CTD PMID:26705709 NCBI chr12:50,400,885...50,480,004
Ensembl chr12:50,392,383...50,480,004
JBrowse link
G LARS1 leucyl-tRNA synthetase 1 increases expression EXP geldanamycin results in increased expression of LARS1 mRNA CTD PMID:26705709 NCBI chr 5:146,113,034...146,182,650
Ensembl chr 5:146,110,566...146,182,696
JBrowse link
G LIMA1 LIM domain and actin binding 1 increases expression EXP geldanamycin results in increased expression of LIMA1 mRNA CTD PMID:26705709 NCBI chr12:50,175,788...50,283,520
Ensembl chr12:50,175,788...50,283,520
JBrowse link
G LIN7A lin-7 homolog A, crumbs cell polarity complex component increases expression EXP geldanamycin results in increased expression of LIN7A mRNA CTD PMID:26705709 NCBI chr12:80,792,520...80,937,934
Ensembl chr12:80,792,520...80,937,934
JBrowse link
G LINC00968 long intergenic non-protein coding RNA 968 increases expression EXP geldanamycin results in increased expression of LINC00968 mRNA CTD PMID:26705709 NCBI chr 8:56,518,318...56,559,823
Ensembl chr 8:56,494,309...56,559,823
JBrowse link
G LMAN1 lectin, mannose binding 1 increases expression EXP geldanamycin results in increased expression of LMAN1 mRNA CTD PMID:26705709 NCBI chr18:59,327,823...59,359,265
Ensembl chr18:59,327,823...59,359,265
JBrowse link
G LMO7 LIM domain 7 increases expression EXP geldanamycin results in increased expression of LMO7 mRNA CTD PMID:26705709 NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870
JBrowse link
G LPP LIM domain containing preferred translocation partner in lipoma increases expression EXP geldanamycin results in increased expression of LPP mRNA CTD PMID:26705709 NCBI chr 3:188,153,021...188,890,671
Ensembl chr 3:188,153,284...188,890,671
JBrowse link
G LRRC58 leucine rich repeat containing 58 increases expression EXP geldanamycin results in increased expression of LRRC58 mRNA CTD PMID:26705709 NCBI chr 3:120,324,509...120,349,354
Ensembl chr 3:120,324,509...120,349,354
JBrowse link
G LSM14B LSM family member 14B increases expression EXP geldanamycin results in increased expression of LSM14B mRNA CTD PMID:26705709 NCBI chr20:62,122,475...62,135,374
Ensembl chr20:62,122,461...62,135,374
JBrowse link
G MALAT1 metastasis associated lung adenocarcinoma transcript 1 increases expression EXP geldanamycin results in increased expression of MALAT1 mRNA CTD PMID:26705709 NCBI chr11:65,497,738...65,506,516
Ensembl chr11:65,497,640...65,508,073
JBrowse link
G MAN1A2 mannosidase alpha class 1A member 2 increases expression EXP geldanamycin results in increased expression of MAN1A2 mRNA CTD PMID:26705709 NCBI chr 1:117,367,449...117,528,872
Ensembl chr 1:117,367,449...117,528,872
JBrowse link
G MAP1B microtubule associated protein 1B increases expression EXP geldanamycin results in increased expression of MAP1B mRNA CTD PMID:26705709 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein
CTD PMID:8816498 PMID:19167484 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 decreases phosphorylation EXP geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122
JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP geldanamycin results in increased expression of MAP3K1 mRNA CTD PMID:26705709 NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 increases expression EXP geldanamycin results in increased expression of MAP3K5 mRNA CTD PMID:26705709 NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097
JBrowse link
G MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 increases expression EXP geldanamycin results in increased expression of MAP4K5 mRNA CTD PMID:26705709 NCBI chr14:50,418,521...50,561,126
Ensembl chr14:50,418,501...50,561,126
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
EXP
ISO
geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 PMID:30166341 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 increases expression EXP geldanamycin results in increased expression of MAPKAPK2 mRNA CTD PMID:26705709 NCBI chr 1:206,684,905...206,734,281
Ensembl chr 1:206,684,905...206,734,281
JBrowse link
G MATR3 matrin 3 increases expression EXP geldanamycin results in increased expression of MATR3 mRNA CTD PMID:26705709 NCBI chr 5:139,274,101...139,331,677
Ensembl chr 5:139,273,752...139,331,671
Ensembl chr 5:139,273,752...139,331,671
JBrowse link
G MBNL1 muscleblind like splicing regulator 1 increases expression EXP geldanamycin results in increased expression of MBNL1 mRNA CTD PMID:26705709 NCBI chr 3:152,243,632...152,465,780
Ensembl chr 3:152,243,828...152,465,780
JBrowse link
G MBNL2 muscleblind like splicing regulator 2 increases expression EXP geldanamycin results in increased expression of MBNL2 mRNA CTD PMID:26705709 NCBI chr13:97,141,834...97,394,120
Ensembl chr13:97,221,434...97,394,120
JBrowse link
G MBTD1 mbt domain containing 1 increases expression EXP geldanamycin results in increased expression of MBTD1 mRNA CTD PMID:26705709 NCBI chr17:51,177,425...51,260,958
Ensembl chr17:51,177,425...51,260,163
JBrowse link
G MCAM melanoma cell adhesion molecule increases expression EXP geldanamycin results in increased expression of MCAM mRNA CTD PMID:26705709 NCBI chr11:119,308,529...119,317,130
Ensembl chr11:119,308,529...119,321,521
JBrowse link
G MCM4 minichromosome maintenance complex component 4 increases expression EXP geldanamycin results in increased expression of MCM4 mRNA CTD PMID:26705709 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MDFIC MyoD family inhibitor domain containing increases expression EXP geldanamycin results in increased expression of MDFIC mRNA CTD PMID:26705709 NCBI chr 7:114,922,094...115,019,917
Ensembl chr 7:114,922,094...115,019,917
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MED13 mediator complex subunit 13 increases expression EXP geldanamycin results in increased expression of MED13 mRNA CTD PMID:26705709 NCBI chr17:61,942,605...62,065,278
Ensembl chr17:61,942,605...62,065,278
JBrowse link
G MED7 mediator complex subunit 7 increases expression EXP geldanamycin results in increased expression of MED7 mRNA CTD PMID:26705709 NCBI chr 5:157,137,424...157,142,865
Ensembl chr 5:157,137,424...157,159,019
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase increases expression EXP geldanamycin results in increased expression of MET mRNA CTD PMID:26705709 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G METTL16 methyltransferase 16, RNA N6-adenosine increases expression EXP geldanamycin results in increased expression of METTL16 mRNA CTD PMID:26705709 NCBI chr17:2,415,715...2,511,888
Ensembl chr17:2,405,562...2,511,891
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase multiple interactions EXP geldanamycin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MIER1 MIER1 transcriptional regulator increases expression EXP geldanamycin results in increased expression of MIER1 mRNA CTD PMID:26705709 NCBI chr 1:66,924,990...66,988,619
Ensembl chr 1:66,924,895...66,988,619
JBrowse link
G MIR21 microRNA 21 increases expression EXP geldanamycin results in increased expression of MIR21 mRNA CTD PMID:26705709 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIS18BP1 MIS18 binding protein 1 increases expression EXP geldanamycin results in increased expression of MIS18BP1 mRNA CTD PMID:26705709 NCBI chr14:45,203,190...45,253,202
Ensembl chr14:45,203,190...45,253,540
JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions
decreases expression
EXP [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA
CTD PMID:12724357 PMID:26705709 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
JBrowse link
G MMP16 matrix metallopeptidase 16 increases expression EXP geldanamycin results in increased expression of MMP16 mRNA CTD PMID:26705709 NCBI chr 8:88,032,011...88,327,483
Ensembl chr 8:88,032,011...88,328,025
JBrowse link
G MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 increases expression EXP geldanamycin results in increased expression of ND6 mRNA CTD PMID:26705709 NCBI chr MT:14,149...14,673
Ensembl chr MT:14,149...14,673
JBrowse link
G MYO5A myosin VA increases expression EXP geldanamycin results in increased expression of MYO5A mRNA CTD PMID:26705709 NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,281...52,529,132
JBrowse link
G MYOCD myocardin increases expression EXP geldanamycin results in increased expression of MYOCD mRNA CTD PMID:26705709 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949
JBrowse link
G MZT1 mitotic spindle organizing protein 1 increases expression EXP geldanamycin results in increased expression of MZT1 mRNA CTD PMID:26705709 NCBI chr13:72,708,367...72,727,629
Ensembl chr13:72,708,367...72,727,629
JBrowse link
G NASP nuclear autoantigenic sperm protein increases expression EXP geldanamycin results in increased expression of NASP mRNA CTD PMID:26705709 NCBI chr 1:45,584,041...45,618,893
Ensembl chr 1:45,583,846...45,618,904
JBrowse link
G NBAS NBAS subunit of NRZ tethering complex increases expression EXP geldanamycin results in increased expression of NBAS mRNA CTD PMID:26705709 NCBI chr 2:14,778,909...15,561,334
Ensembl chr 2:15,166,916...15,561,340
JBrowse link
G NCOA2 nuclear receptor coactivator 2 increases expression EXP geldanamycin results in increased expression of NCOA2 mRNA CTD PMID:26705709 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 increases expression EXP geldanamycin results in increased expression of NEDD9 mRNA CTD PMID:26705709 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348
JBrowse link
G NES nestin increases expression EXP geldanamycin results in increased expression of NES mRNA CTD PMID:26705709 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
JBrowse link
G NF1 neurofibromin 1 increases expression EXP geldanamycin results in increased expression of NF1 mRNA CTD PMID:26705709 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116
JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor increases expression EXP geldanamycin results in increased expression of NF2 mRNA CTD PMID:26705709 NCBI chr22:29,603,556...29,698,600
Ensembl chr22:29,603,556...29,698,598
JBrowse link
G NFAT5 nuclear factor of activated T cells 5 increases expression EXP geldanamycin results in increased expression of NFAT5 mRNA CTD PMID:26705709 NCBI chr16:69,565,966...69,704,654
Ensembl chr16:69,565,094...69,704,666
JBrowse link
G NIPBL NIPBL cohesin loading factor increases expression EXP geldanamycin results in increased expression of NIPBL mRNA CTD PMID:26705709 NCBI chr 5:36,876,769...37,066,413
Ensembl chr 5:36,876,769...37,066,413
JBrowse link
G NKTR natural killer cell triggering receptor increases expression EXP geldanamycin results in increased expression of NKTR mRNA CTD PMID:26705709 NCBI chr 3:42,600,612...42,648,735
Ensembl chr 3:42,600,655...42,648,735
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA]
geldanamycin inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
CTD PMID:11835313 PMID:15583003 PMID:37586545 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPR3 natriuretic peptide receptor 3 increases expression EXP geldanamycin results in increased expression of NPR3 mRNA CTD PMID:26705709 NCBI chr 5:32,690,872...32,791,720
Ensembl chr 5:32,689,070...32,791,724
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases reduction EXP NQO1 protein results in increased reduction of geldanamycin CTD PMID:16825487 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR2C2 nuclear receptor subfamily 2 group C member 2 increases expression EXP geldanamycin results in increased expression of NR2C2 mRNA CTD PMID:26705709 NCBI chr 3:14,947,583...15,049,273
Ensembl chr 3:14,947,583...15,053,600
JBrowse link
G NRK Nik related kinase increases expression EXP geldanamycin results in increased expression of NRK mRNA CTD PMID:26705709 NCBI chr  X:105,821,786...105,958,610
Ensembl chr  X:105,822,539...105,958,610
JBrowse link
G OSBPL8 oxysterol binding protein like 8 increases expression EXP geldanamycin results in increased expression of OSBPL8 mRNA CTD PMID:26705709 NCBI chr12:76,351,797...76,559,771
Ensembl chr12:76,351,797...76,559,809
JBrowse link
G OTUD4 OTU deubiquitinase 4 increases expression EXP geldanamycin results in increased expression of OTUD4 mRNA CTD PMID:26705709 NCBI chr 4:145,133,650...145,180,589
Ensembl chr 4:145,110,838...145,180,589
JBrowse link
G OXTR oxytocin receptor increases expression EXP geldanamycin results in increased expression of OXTR mRNA CTD PMID:26705709 NCBI chr 3:8,741,269...8,769,613
Ensembl chr 3:8,750,381...8,769,628
JBrowse link
G P2RX1 purinergic receptor P2X 1 multiple interactions ISO geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr17:3,896,592...3,916,465
Ensembl chr17:3,896,592...3,916,476
JBrowse link
G PAPPA pappalysin 1 increases expression EXP geldanamycin results in increased expression of PAPPA mRNA CTD PMID:26705709 NCBI chr 9:116,153,791...116,402,321
Ensembl chr 9:116,153,791...116,402,321
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases degradation
EXP geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509 PMID:17293044 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCBP2 poly(rC) binding protein 2 increases expression EXP geldanamycin results in increased expression of PCBP2 mRNA CTD PMID:26705709 NCBI chr12:53,452,102...53,481,162
Ensembl chr12:53,452,102...53,481,162
JBrowse link
G PCM1 pericentriolar material 1 increases expression EXP geldanamycin results in increased expression of PCM1 mRNA CTD PMID:26705709 NCBI chr 8:17,922,988...18,029,948
Ensembl chr 8:17,922,842...18,029,948
JBrowse link
G PDE4DIP phosphodiesterase 4D interacting protein increases expression EXP geldanamycin results in increased expression of PDE4DIP mRNA CTD PMID:26705709 NCBI chr 1:148,808,434...149,033,016
Ensembl chr 1:148,808,140...149,048,286
JBrowse link
G PDGFA platelet derived growth factor subunit A increases expression EXP geldanamycin results in increased expression of PDGFA mRNA CTD PMID:26705709 NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296
JBrowse link
G PEG10 paternally expressed 10 increases expression EXP geldanamycin results in increased expression of PEG10 mRNA CTD PMID:26705709 NCBI chr 7:94,656,325...94,669,695
Ensembl chr 7:94,656,325...94,669,695
JBrowse link
G PGR progesterone receptor decreases expression EXP geldanamycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PHACTR2 phosphatase and actin regulator 2 increases expression EXP geldanamycin results in increased expression of PHACTR2 mRNA CTD PMID:26705709 NCBI chr 6:143,536,878...143,831,185
Ensembl chr 6:143,536,845...143,831,185
JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 increases expression EXP geldanamycin results in increased expression of PHLDB2 mRNA CTD PMID:26705709 NCBI chr 3:111,732,496...111,976,517
Ensembl chr 3:111,732,497...111,976,517
JBrowse link
G PHTF2 putative homeodomain transcription factor 2 increases expression EXP geldanamycin results in increased expression of PHTF2 mRNA CTD PMID:26705709 NCBI chr 7:77,798,773...77,957,504
Ensembl chr 7:77,798,773...77,957,503
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha increases expression EXP geldanamycin results in increased expression of PIK3CA mRNA CTD PMID:26705709 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA CTD PMID:12724357 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLPPR4 phospholipid phosphatase related 4 increases expression EXP geldanamycin results in increased expression of PLPPR4 mRNA CTD PMID:26705709 NCBI chr 1:99,262,924...99,309,584
Ensembl chr 1:99,264,292...99,309,590
JBrowse link
G PLXNA2 plexin A2 increases expression EXP geldanamycin results in increased expression of PLXNA2 mRNA CTD PMID:26705709 NCBI chr 1:208,022,242...208,244,384
Ensembl chr 1:208,022,242...208,244,384
JBrowse link
G POLR2B RNA polymerase II subunit B decreases expression EXP geldanamycin results in decreased expression of POLR2B mRNA CTD PMID:30166341 NCBI chr 4:56,978,896...57,031,158
Ensembl chr 4:56,977,722...57,031,158
JBrowse link
G PPM1K protein phosphatase, Mg2+/Mn2+ dependent 1K increases expression EXP geldanamycin results in increased expression of PPM1K mRNA CTD PMID:26705709 NCBI chr 4:88,257,620...88,284,561
Ensembl chr 4:88,257,620...88,284,769
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein CTD PMID:37481222 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA2 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA2 protein CTD PMID:37481222 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 increases expression EXP geldanamycin results in increased expression of PRKG1 mRNA CTD PMID:26705709 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G PRMT2 protein arginine methyltransferase 2 increases expression EXP geldanamycin results in increased expression of PRMT2 mRNA CTD PMID:26705709 NCBI chr21:46,635,674...46,665,124
Ensembl chr21:46,635,595...46,665,124
JBrowse link
G PRPF6 pre-mRNA processing factor 6 increases expression EXP geldanamycin results in increased expression of PRPF6 mRNA CTD PMID:26705709 NCBI chr20:63,981,132...64,033,100
Ensembl chr20:63,981,132...64,033,100
JBrowse link
G PRR14L proline rich 14 like increases expression EXP geldanamycin results in increased expression of PRR14L mRNA CTD PMID:26705709 NCBI chr22:31,681,347...31,750,132
Ensembl chr22:31,676,256...31,750,140
JBrowse link
G PRRC2C proline rich coiled-coil 2C increases expression EXP geldanamycin results in increased expression of PRRC2C mRNA CTD PMID:26705709 NCBI chr 1:171,485,530...171,593,511
Ensembl chr 1:171,485,530...171,593,511
JBrowse link
G PSME4 proteasome activator subunit 4 increases expression EXP geldanamycin results in increased expression of PSME4 mRNA CTD PMID:26705709 NCBI chr 2:53,864,069...53,970,993
Ensembl chr 2:53,864,069...53,970,993
JBrowse link
G PTAR1 protein prenyltransferase alpha subunit repeat containing 1 increases expression EXP geldanamycin results in increased expression of PTAR1 mRNA CTD PMID:26705709 NCBI chr 9:69,709,525...69,760,011
Ensembl chr 9:69,709,522...69,760,011
JBrowse link
G PTBP3 polypyrimidine tract binding protein 3 increases expression EXP geldanamycin results in increased expression of PTBP3 mRNA CTD PMID:26705709 NCBI chr 9:112,217,715...112,379,882
Ensembl chr 9:112,217,716...112,333,664
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression EXP geldanamycin results in decreased expression of PTGS1 mRNA CTD PMID:26705709 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:11133817 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTHLH parathyroid hormone like hormone multiple interactions EXP [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733
JBrowse link
G PTK2 protein tyrosine kinase 2 increases degradation
decreases phosphorylation
EXP
ISO
geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein
CTD PMID:9973544 PMID:12811834 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 increases expression EXP geldanamycin results in increased expression of PTPN11 mRNA CTD PMID:26705709 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918
JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 increases expression EXP geldanamycin results in increased expression of PTPN12 mRNA CTD PMID:26705709 NCBI chr 7:77,537,295...77,640,069
Ensembl chr 7:77,537,295...77,640,069
JBrowse link
G PTPRA protein tyrosine phosphatase receptor type A increases expression EXP geldanamycin results in increased expression of PTPRA mRNA CTD PMID:26705709 NCBI chr20:2,864,184...3,038,669
Ensembl chr20:2,873,420...3,039,076
JBrowse link
G PTPRD protein tyrosine phosphatase receptor type D increases expression EXP geldanamycin results in increased expression of PTPRD mRNA CTD PMID:26705709 NCBI chr 9:8,314,246...10,613,002
Ensembl chr 9:8,314,246...10,613,002
JBrowse link
G PWAR5 Prader Willi/Angelman region RNA 5 increases expression EXP geldanamycin results in increased expression of PWAR5 mRNA CTD PMID:26705709 NCBI chr15:24,984,860...24,988,232
Ensembl chr15:24,985,053...24,988,232
JBrowse link
G PYGO1 pygopus family PHD finger 1 increases expression EXP geldanamycin results in increased expression of PYGO1 mRNA CTD PMID:26705709 NCBI chr15:55,538,884...55,588,971
Ensembl chr15:55,538,884...55,588,947
JBrowse link
G RAB3B RAB3B, member RAS oncogene family increases expression EXP geldanamycin results in increased expression of RAB3B mRNA CTD PMID:26705709 NCBI chr 1:51,907,956...51,990,700
Ensembl chr 1:51,907,956...51,990,700
JBrowse link
G RABEP1 rabaptin, RAB GTPase binding effector protein 1 increases expression EXP geldanamycin results in increased expression of RABEP1 mRNA CTD PMID:26705709 NCBI chr17:5,282,284...5,386,340
Ensembl chr17:5,282,265...5,386,340
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
decreases expression
multiple interactions
ISO
EXP
geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein
CTD PMID:8816498 PMID:19167484 PMID:24450340 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 increases expression EXP geldanamycin results in increased expression of RAPGEF2 mRNA CTD PMID:26705709 NCBI chr 4:159,103,079...159,360,173
Ensembl chr 4:159,103,013...159,360,174
JBrowse link
G RASSF8 Ras association domain family member 8 increases expression EXP geldanamycin results in increased expression of RASSF8 mRNA CTD PMID:26705709 NCBI chr12:25,958,232...26,079,889
Ensembl chr12:25,958,232...26,079,892
JBrowse link
G RBAK RB associated KRAB zinc finger increases expression EXP geldanamycin results in increased expression of RBAK mRNA CTD PMID:26705709 NCBI chr 7:5,045,860...5,069,487
Ensembl chr 7:5,045,821...5,069,487
JBrowse link
G RBM26 RNA binding motif protein 26 increases expression EXP geldanamycin results in increased expression of RBM26 mRNA CTD PMID:26705709 NCBI chr13:79,311,827...79,406,255
Ensembl chr13:79,311,824...79,406,477
JBrowse link
G RBMS3 RNA binding motif single stranded interacting protein 3 increases expression EXP geldanamycin results in increased expression of RBMS3 mRNA CTD PMID:26705709 NCBI chr 3:29,281,071...30,010,395
Ensembl chr 3:28,574,791...30,010,391
JBrowse link
G RCAN1 regulator of calcineurin 1 increases expression EXP geldanamycin results in increased expression of RCAN1 mRNA CTD PMID:26705709 NCBI chr21:34,516,442...34,615,113
Ensembl chr21:34,513,142...34,615,113
JBrowse link
G RDH10 retinol dehydrogenase 10 increases expression EXP geldanamycin results in increased expression of RDH10 mRNA CTD PMID:26705709 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP geldanamycin inhibits the reaction [TNF protein affects the localization of RELA protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of RELA mRNA] CTD PMID:37586545 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RESF1 retroelement silencing factor 1 increases expression EXP geldanamycin results in increased expression of KIAA1551 mRNA CTD PMID:26705709 NCBI chr12:31,959,415...31,993,107
Ensembl chr12:31,959,370...31,993,107
JBrowse link
G RFX7 regulatory factor X7 increases expression EXP geldanamycin results in increased expression of RFX7 mRNA CTD PMID:26705709 NCBI chr15:56,087,280...56,245,082
Ensembl chr15:56,087,280...56,245,082
JBrowse link
G RNGTT RNA guanylyltransferase and 5'-phosphatase increases expression
decreases expression
EXP geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein
CTD PMID:26705709 PMID:30166341 NCBI chr 6:88,609,897...88,963,618
Ensembl chr 6:88,609,897...88,963,618
JBrowse link
G RO60 Ro60, Y RNA binding protein increases expression EXP geldanamycin results in increased expression of TROVE2 mRNA CTD PMID:26705709 NCBI chr 1:193,059,612...193,091,777
Ensembl chr 1:193,059,454...193,091,777
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 increases expression EXP geldanamycin results in increased expression of ROCK2 mRNA CTD PMID:26705709 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330
JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 decreases expression EXP geldanamycin results in decreased expression of RPLP0 mRNA CTD PMID:30166341 NCBI chr12:120,196,699...120,201,111
Ensembl chr12:120,196,699...120,201,235
JBrowse link
G RTTN rotatin increases expression EXP geldanamycin results in increased expression of RTTN mRNA CTD PMID:26705709 NCBI chr18:70,003,031...70,205,687
Ensembl chr18:70,003,031...70,205,726
JBrowse link
G RUFY2 RUN and FYVE domain containing 2 increases expression EXP geldanamycin results in increased expression of RUFY2 mRNA CTD PMID:26705709 NCBI chr10:68,341,112...68,407,277
Ensembl chr10:68,341,107...68,407,294
JBrowse link
G S100A4 S100 calcium binding protein A4 decreases expression EXP geldanamycin results in decreased expression of S100A4 mRNA CTD PMID:26705709 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G SAMD5 sterile alpha motif domain containing 5 increases expression EXP geldanamycin results in increased expression of SAMD5 mRNA CTD PMID:26705709 NCBI chr 6:147,508,690...147,954,680
Ensembl chr 6:147,508,690...147,737,547
JBrowse link
G SAR1B secretion associated Ras related GTPase 1B increases expression EXP geldanamycin results in increased expression of SAR1B mRNA CTD PMID:26705709 NCBI chr 5:134,601,149...134,632,828
Ensembl chr 5:134,601,149...134,649,271
JBrowse link
G SCRN3 secernin 3 increases expression EXP geldanamycin results in increased expression of SCRN3 mRNA CTD PMID:26705709 NCBI chr 2:174,395,730...174,430,071
Ensembl chr 2:174,395,730...174,429,575
JBrowse link
G SCYL2 SCY1 like pseudokinase 2 increases expression EXP geldanamycin results in increased expression of SCYL2 mRNA CTD PMID:26705709 NCBI chr12:100,267,177...100,341,715
Ensembl chr12:100,267,140...100,341,715
JBrowse link
G SEMA3D semaphorin 3D increases expression EXP geldanamycin results in increased expression of SEMA3D mRNA CTD PMID:26705709 NCBI chr 7:84,995,553...85,250,243
Ensembl chr 7:84,995,553...85,187,056
JBrowse link
G SENP1 SUMO specific peptidase 1 increases expression EXP geldanamycin results in increased expression of SENP1 mRNA CTD PMID:26705709 NCBI chr12:48,042,897...48,106,079
Ensembl chr12:48,039,784...48,106,079
JBrowse link
G SEPTIN7P2 septin 7 pseudogene 2 increases expression EXP geldanamycin results in increased expression of SEPTIN7P2 mRNA CTD PMID:26705709 NCBI chr 7:45,723,787...45,769,018
Ensembl chr 7:45,736,787...45,765,812
JBrowse link
G SERPINE1 serpin family E member 1 increases expression EXP geldanamycin results in increased expression of SERPINE1 mRNA CTD PMID:26705709 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SESN3 sestrin 3 increases expression EXP geldanamycin results in increased expression of SESN3 mRNA CTD PMID:26705709 NCBI chr11:95,165,513...95,232,475
Ensembl chr11:95,165,513...95,232,541
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase increases expression EXP geldanamycin results in increased expression of SETD2 mRNA CTD PMID:26705709 NCBI chr 3:47,016,436...47,164,840
Ensembl chr 3:47,016,428...47,164,113
JBrowse link
G SETX senataxin increases expression EXP geldanamycin results in increased expression of SETX mRNA CTD PMID:26705709 NCBI chr 9:132,261,356...132,356,744
Ensembl chr 9:132,261,356...132,354,986
JBrowse link
G SFPQ splicing factor proline and glutamine rich increases expression EXP geldanamycin results in increased expression of SFPQ mRNA CTD PMID:26705709 NCBI chr 1:35,176,380...35,193,145
Ensembl chr 1:35,176,378...35,193,446
JBrowse link
G SGMS2 sphingomyelin synthase 2 increases expression EXP geldanamycin results in increased expression of SGMS2 mRNA CTD PMID:26705709 NCBI chr 4:107,824,563...107,915,047
Ensembl chr 4:107,824,563...107,915,047
JBrowse link
G SIKE1 suppressor of IKBKE 1 increases expression EXP geldanamycin results in increased expression of SIKE1 mRNA CTD PMID:26705709 NCBI chr 1:114,769,479...114,780,685
Ensembl chr 1:114,769,479...114,780,685
JBrowse link
G SKIC3 SKI3 subunit of superkiller complex increases expression EXP geldanamycin results in increased expression of SKIC3 mRNA CTD PMID:26705709 NCBI chr 5:95,463,894...95,554,977
Ensembl chr 5:95,461,755...95,555,050
JBrowse link
G SLAIN2 SLAIN motif family member 2 increases expression EXP geldanamycin results in increased expression of SLAIN2 mRNA CTD PMID:26705709 NCBI chr 4:48,341,529...48,426,201
Ensembl chr 4:48,341,529...48,426,201
JBrowse link
G SLC16A1 solute carrier family 16 member 1 increases expression EXP geldanamycin results in increased expression of SLC16A1 mRNA CTD PMID:26705709 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SLC16A7 solute carrier family 16 member 7 increases expression EXP geldanamycin results in increased expression of SLC16A7 mRNA CTD PMID:26705709 NCBI chr12:59,596,029...59,789,841
Ensembl chr12:59,596,029...59,789,855
JBrowse link
G SLC2A13 solute carrier family 2 member 13 increases expression EXP geldanamycin results in increased expression of SLC2A13 mRNA CTD PMID:26705709 NCBI chr12:39,755,025...40,106,081
Ensembl chr12:39,755,025...40,106,089
JBrowse link
G SLC38A1 solute carrier family 38 member 1 increases expression EXP geldanamycin results in increased expression of SLC38A1 mRNA CTD PMID:26705709 NCBI chr12:46,183,063...46,269,043
Ensembl chr12:46,183,063...46,270,017
JBrowse link
G SLC39A6 solute carrier family 39 member 6 increases expression EXP geldanamycin results in increased expression of SLC39A6 mRNA CTD PMID:26705709 NCBI chr18:36,108,531...36,129,340
Ensembl chr18:36,108,531...36,129,385
JBrowse link
G SLC8A1 solute carrier family 8 member A1 increases expression EXP geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SLFN5 schlafen family member 5 increases expression EXP geldanamycin results in increased expression of SLFN5 mRNA CTD PMID:26705709 NCBI chr17:35,243,072...35,273,655
Ensembl chr17:35,243,071...35,273,655
JBrowse link
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 increases expression EXP geldanamycin results in increased expression of SMARCA2 mRNA CTD PMID:26705709 NCBI chr 9:2,015,347...2,193,624
Ensembl chr 9:1,980,290...2,193,624
JBrowse link
G SMC1A structural maintenance of chromosomes 1A increases expression EXP geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 NCBI chr  X:53,374,149...53,422,728
Ensembl chr  X:53,374,149...53,422,728
JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 increases expression EXP geldanamycin results in increased expression of SMCHD1 mRNA CTD PMID:26705709 NCBI chr18:2,655,726...2,805,017
Ensembl chr18:2,655,726...2,805,017
JBrowse link
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 increases expression EXP geldanamycin results in increased expression of SOS2 mRNA CTD PMID:26705709 NCBI chr14:50,117,130...50,231,88