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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.22.* (cysteine endopeptidase) inhibitor
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Accession:CHEBI:76796 term browser browse the term
Definition:An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the action of any cysteine endopeptidase (EC 3.4.22.*).
Synonyms:related_synonym: EC 3.4.22.* inhibitor;   EC 3.4.22.* inhibitors;   cysteine endopeptidase (EC 3.4.22.*) inhibitors;   cysteine endopeptidase inhibitor;   cysteine endopeptidase inhibitors


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acetylleucyl-leucyl-norleucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G APOB apolipoprotein B multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Glucosamine results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal results in increased expression of and results in increased secretion of APOB protein CTD PMID:19342510, PMID:19383982 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of BIRC5 protein] CTD PMID:29974605 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
ISO acetylleucyl-leucyl-norleucinal results in increased activity of CASP3 protein
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:15618349, PMID:27481217, PMID:29111403 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions EXP acetylleucyl-leucyl-norleucinal promotes the reaction [Immunologic Factors results in increased expression of CASP7 protein modified form] CTD PMID:29974605 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] CTD PMID:17373649 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Resveratrol results in increased degradation of CCND1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND1 protein] CTD PMID:11895924, PMID:16024653 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND3 cyclin D3 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein] CTD PMID:16024653 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CDC20 cell division cycle 20 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]; acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein] CTD PMID:20054826 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of CTNNB1 protein] CTD PMID:29974605 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Antimycin A inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; diphenyleneiodonium inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Rotenone inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA] CTD PMID:12208513 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DNM1L dynamin 1 like multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:27481217 NCBI chr12:32,679,296...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G EIF4E eukaryotic translation initiation factor 4E multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,871,684...98,930,637
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] CTD PMID:17291458 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP acetylleucyl-leucyl-norleucinal promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of JUN protein CTD PMID:15618349 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of MAPK8 protein CTD PMID:15618349 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of MYC protein] CTD PMID:29974605 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
decreases degradation
EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased degradation of and results in decreased expression of NFKBIA protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein]
acetylleucyl-leucyl-norleucinal results in decreased degradation of NFKBIA protein
CTD PMID:15930313, PMID:17291458, PMID:18606398 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G RAD51 RAD51 recombinase multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] CTD PMID:21810436 NCBI chr15:40,694,774...40,732,340
Ensembl chr15:40,694,774...40,732,340
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region increases expression EXP acetylleucyl-leucyl-norleucinal results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G SCNN1G sodium channel epithelial 1 subunit gamma increases methylation
decreases expression
EXP acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoter
acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNA
CTD PMID:15564131 NCBI chr16:23,182,745...23,216,883
Ensembl chr16:23,182,745...23,216,883
JBrowse link
G SLC38A3 solute carrier family 38 member 3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 3:50,205,268...50,221,486
Ensembl chr 3:50,205,246...50,221,486
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [SGA 360 results in increased degradation of and results in decreased expression of SREBF1 protein] CTD PMID:31225620 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TTN titin multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein] CTD PMID:22532871 NCBI chr 2:178,525,989...178,807,423
Ensembl chr 2:178,525,989...178,830,802
JBrowse link
G TYMP thymidine phosphorylase multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] CTD PMID:21444628, PMID:30796972 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G TYMS thymidylate synthetase multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein] CTD PMID:21444628 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
aloxistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 multiple interactions EXP aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN7 calpain 7 multiple interactions EXP aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 3:15,206,246...15,252,916
Ensembl chr 3:15,206,152...15,252,916
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein] CTD PMID:26853465 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CTSB cathepsin B multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806, PMID:32186374 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CTSD cathepsin D multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein CTD PMID:32186374 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CTSL cathepsin L multiple interactions EXP aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,726,109...87,731,469
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365
Ensembl chr  X:120,426,148...120,469,365
JBrowse link
G SMN2 survival of motor neuron 2, centromeric multiple interactions EXP aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 5:70,049,523...70,077,595
Ensembl chr 5:70,049,612...70,078,522
Ensembl chr 5:70,049,612...70,078,522
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein CTD PMID:32186374 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
amentoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIF1 allograft inflammatory factor 1 multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:28185818 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] CTD PMID:28185818 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO
EXP
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD PMID:28185818 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:28185818 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:28185818 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP amentoflavone results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DCT dopachrome tautomerase decreases expression EXP amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein CTD PMID:17473463 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:28185818 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein] CTD PMID:28185818 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein] CTD PMID:28185818 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein] CTD PMID:28185818 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
amentoflavone results in decreased expression of NOS2 protein
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:12144868, PMID:28185818 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PTGDS prostaglandin D2 synthase affects binding EXP amentoflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein
[amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
CTD PMID:12144868 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:28185818 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TYR tyrosinase decreases activity EXP amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 decreases activity EXP amentoflavone results in decreased activity of UGT1A1 protein CTD PMID:29470958 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 decreases activity EXP amentoflavone results in decreased activity of UGT1A10 protein CTD PMID:29470958 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 decreases activity EXP amentoflavone results in decreased activity of UGT1A3 protein CTD PMID:29470958 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299
JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 decreases activity EXP amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,778...233,773,299
Ensembl chr 2:233,718,778...233,773,299
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 decreases activity
multiple interactions
EXP amentoflavone results in decreased activity of UGT1A6 protein
amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
CTD PMID:29470958, PMID:32421801 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 decreases activity EXP amentoflavone results in decreased activity of UGT1A7 protein CTD PMID:29470958 NCBI chr 2:233,681,938...233,773,299
Ensembl chr 2:233,681,938...233,773,299
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 decreases activity EXP amentoflavone results in decreased activity of UGT1A8 protein CTD PMID:29470958 NCBI chr 2:233,617,645...233,773,299
Ensembl chr 2:233,617,645...233,773,310
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 decreases activity EXP amentoflavone results in decreased activity of UGT1A9 protein CTD PMID:29470958 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 decreases activity EXP amentoflavone results in decreased activity of UGT2B17 protein CTD PMID:29470958 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527
JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 decreases activity EXP amentoflavone results in decreased activity of UGT2B4 protein CTD PMID:29470958 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014
JBrowse link
cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression EXP cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B decreases expression EXP cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,136
Ensembl chr15:40,161,023...40,221,136
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 increases expression EXP cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDC25C cell division cycle 25C decreases expression EXP cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDC34 cell division cycle 34, ubiqiutin conjugating enzyme decreases expression EXP cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr19:531,720...542,088
Ensembl chr19:531,760...542,092
JBrowse link
G CDC45 cell division cycle 45 decreases expression EXP cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr22:19,479,294...19,520,612
Ensembl chr22:19,479,457...19,520,612
JBrowse link
G CDC6 cell division cycle 6 decreases expression EXP cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr17:40,287,878...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 decreases expression EXP cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:54,396,873...54,420,218
Ensembl chr14:54,396,849...54,420,218
JBrowse link
G CENPF centromere protein F decreases expression EXP cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,195...214,664,571
JBrowse link
G GDF15 growth differentiation factor 15 increases expression EXP cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G MCM2 minichromosome maintenance complex component 2 decreases expression EXP cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MCM6 minichromosome maintenance complex component 6 decreases expression EXP cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G MCM7 minichromosome maintenance complex component 7 decreases expression EXP cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,728...100,101,940
JBrowse link
G MCM8 minichromosome maintenance 8 homologous recombination repair factor decreases expression EXP cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr20:5,950,652...6,000,941
Ensembl chr20:5,950,652...5,998,977
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MYT1 myelin transcription factor 1 decreases expression EXP cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr20:64,164,452...64,242,253
Ensembl chr20:64,102,394...64,242,253
JBrowse link
G NEK2 NIMA related kinase 2 decreases expression EXP cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:211,658,256...211,675,625
Ensembl chr 1:211,658,657...211,675,630
JBrowse link
G TP53 tumor protein p53 increases expression
increases activity
EXP cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein
CTD PMID:16120219 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TTK TTK protein kinase decreases expression EXP cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 6:80,004,147...80,042,651
Ensembl chr 6:80,003,887...80,042,527
JBrowse link
geldanamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression EXP geldanamycin results in increased expression of ACAP2 mRNA CTD PMID:26705709 NCBI chr 3:195,274,742...195,443,176
Ensembl chr 3:195,274,745...195,443,044
JBrowse link
G ACTR2 actin related protein 2 increases expression EXP geldanamycin results in increased expression of ACTR2 mRNA CTD PMID:26705709 NCBI chr 2:65,227,831...65,271,253
Ensembl chr 2:65,227,788...65,271,253
Ensembl chr 2:65,227,788...65,271,253
JBrowse link
G AFF3 AF4/FMR2 family member 3 increases expression EXP geldanamycin results in increased expression of AFF3 mRNA CTD PMID:26705709 NCBI chr 2:99,545,419...100,142,590
Ensembl chr 2:99,545,419...100,192,428
JBrowse link
G AFF4 AF4/FMR2 family member 4 increases expression EXP geldanamycin results in increased expression of AFF4 mRNA CTD PMID:26705709 NCBI chr 5:132,875,381...132,963,655
Ensembl chr 5:132,875,395...132,963,634
JBrowse link
G AGFG1 ArfGAP with FG repeats 1 increases expression EXP geldanamycin results in increased expression of AGFG1 mRNA CTD PMID:26705709 NCBI chr 2:227,472,156...227,561,217
Ensembl chr 2:227,472,152...227,561,214
JBrowse link
G AHR aryl hydrocarbon receptor increases localization
decreases expression
increases degradation
multiple interactions
EXP
ISO
geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
CTD PMID:9664232, PMID:12237327, PMID:12606767, PMID:16226227, PMID:20057149, PMID:27105554 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein
CTD PMID:15781649, PMID:17293044, PMID:19167484, PMID:24211270, PMID:24450340 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT3 AKT serine/threonine kinase 3 increases expression EXP geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 NCBI chr 1:243,488,233...243,851,079
Ensembl chr 1:243,488,233...243,851,079
JBrowse link
G AMOTL1 angiomotin like 1 increases expression EXP geldanamycin results in increased expression of AMOTL1 mRNA CTD PMID:26705709 NCBI chr11:94,706,418...94,876,748
Ensembl chr11:94,706,431...94,876,748
JBrowse link
G ANGPT1 angiopoietin 1 increases expression EXP geldanamycin results in increased expression of ANGPT1 mRNA CTD PMID:26705709 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G ANGPTL1 angiopoietin like 1 decreases expression EXP geldanamycin results in decreased expression of ANGPTL1 mRNA CTD PMID:26705709 NCBI chr 1:178,849,535...178,871,077
Ensembl chr 1:178,849,535...178,871,077
JBrowse link
G ANKRD1 ankyrin repeat domain 1 increases expression EXP geldanamycin results in increased expression of ANKRD1 mRNA CTD PMID:26705709 NCBI chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087
JBrowse link
G AP5M1 adaptor related protein complex 5 subunit mu 1 increases expression EXP geldanamycin results in increased expression of AP5M1 mRNA CTD PMID:26705709 NCBI chr14:57,268,915...57,298,742
Ensembl chr14:57,268,924...57,298,742
JBrowse link
G APELA apelin receptor early endogenous ligand increases expression EXP geldanamycin results in increased expression of APELA mRNA CTD PMID:26705709 NCBI chr 4:164,877,023...164,899,063
Ensembl chr 4:164,877,178...164,898,965
JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 increases expression EXP geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 NCBI chr12:105,173,297...105,236,174
Ensembl chr12:105,173,297...105,236,203
JBrowse link
G ARFIP1 ADP ribosylation factor interacting protein 1 increases expression EXP geldanamycin results in increased expression of ARFIP1 mRNA CTD PMID:26705709 NCBI chr 4:152,779,954...152,912,357
Ensembl chr 4:152,779,937...152,918,463
JBrowse link
G ASPM assembly factor for spindle microtubules increases expression EXP geldanamycin results in increased expression of ASPM mRNA CTD PMID:26705709 NCBI chr 1:197,084,127...197,146,669
Ensembl chr 1:197,084,127...197,146,694
JBrowse link
G ATP11B ATPase phospholipid transporting 11B (putative) increases expression EXP geldanamycin results in increased expression of ATP11B mRNA CTD PMID:26705709 NCBI chr 3:182,793,504...182,923,010
Ensembl chr 3:182,793,503...182,921,629
JBrowse link
G ATP11C ATPase phospholipid transporting 11C increases expression EXP geldanamycin results in increased expression of ATP11C mRNA CTD PMID:26705709 NCBI chr  X:139,726,346...139,933,083
Ensembl chr  X:139,726,346...139,945,276
JBrowse link
G ATP13A3 ATPase 13A3 increases expression EXP geldanamycin results in increased expression of ATP13A3 mRNA CTD PMID:26705709 NCBI chr 3:194,402,674...194,487,006
Ensembl chr 3:194,402,672...194,498,364
JBrowse link
G ATP13A5 ATPase 13A5 increases expression EXP geldanamycin results in increased expression of ATP13A5 mRNA CTD PMID:26705709 NCBI chr 3:193,274,789...193,378,820
Ensembl chr 3:193,274,789...193,378,820
JBrowse link
G ATRX ATRX chromatin remodeler increases expression EXP geldanamycin results in increased expression of ATRX mRNA CTD PMID:26705709 NCBI chr  X:77,504,880...77,786,235
Ensembl chr  X:77,504,880...77,786,233
Ensembl chr  X:77,504,880...77,786,233
JBrowse link
G ATXN7L3B ataxin 7 like 3B increases expression EXP geldanamycin results in increased expression of ATXN7L3B mRNA CTD PMID:26705709 NCBI chr12:74,537,835...74,545,430
Ensembl chr12:74,537,835...74,545,430
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein
geldanamycin results in decreased expression of BCL2 protein
CTD PMID:15781649, PMID:28673683 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases response to substance
multiple interactions
EXP BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein
CTD PMID:15781649 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCOR BCL6 corepressor increases expression EXP geldanamycin results in increased expression of BCOR mRNA CTD PMID:26705709 NCBI chr  X:40,051,246...40,177,390
Ensembl chr  X:40,049,815...40,177,329
JBrowse link
G BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression EXP geldanamycin results in increased expression of BDP1 mRNA CTD PMID:26705709 NCBI chr 5:71,455,636...71,578,288
Ensembl chr 5:71,455,651...71,567,820
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein CTD PMID:15781649 NCBI chr11:102,347,182...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BOD1L1 biorientation of chromosomes in cell division 1 like 1 increases expression EXP geldanamycin results in increased expression of BOD1L1 mRNA CTD PMID:26705709 NCBI chr 4:13,568,738...13,627,725
Ensembl chr 4:13,568,738...13,627,725
JBrowse link
G C5orf22 chromosome 5 open reading frame 22 increases expression EXP geldanamycin results in increased expression of C5ORF22 mRNA CTD PMID:26705709 NCBI chr 5:31,532,275...31,555,053
Ensembl chr 5:31,532,287...31,555,053
JBrowse link
G C5orf24 chromosome 5 open reading frame 24 increases expression EXP geldanamycin results in increased expression of C5ORF24 mRNA CTD PMID:26705709 NCBI chr 5:134,833,603...134,859,735
Ensembl chr 5:134,845,680...134,859,735
JBrowse link
G CAB39 calcium binding protein 39 increases expression EXP geldanamycin results in increased expression of CAB39 mRNA CTD PMID:26705709 NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075
JBrowse link
G CALD1 caldesmon 1 increases expression EXP geldanamycin results in increased expression of CALD1 mRNA CTD PMID:26705709 NCBI chr 7:134,779,629...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CASK calcium/calmodulin dependent serine protein kinase increases expression EXP geldanamycin results in increased expression of CASK mRNA CTD PMID:26705709 NCBI chr  X:41,514,934...41,923,554
Ensembl chr  X:41,514,934...41,923,517
Ensembl chr  X:41,514,934...41,923,517
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] CTD PMID:12115584, PMID:12530016, PMID:14576064, PMID:24998639 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein] CTD PMID:24998639 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 multiple interactions EXP geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] CTD PMID:16311509 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CBL Cbl proto-oncogene increases expression EXP geldanamycin results in increased expression of CBL mRNA CTD PMID:26705709 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
Ensembl chr11:119,206,298...119,313,926
JBrowse link
G CCDC186 coiled-coil domain containing 186 increases expression EXP geldanamycin results in increased expression of CCDC186 mRNA CTD PMID:26705709 NCBI chr10:114,120,862...114,174,255
Ensembl chr10:114,120,862...114,174,232
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
EXP [geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein
CTD PMID:15781649, PMID:17959518, PMID:24211270 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 increases expression EXP geldanamycin results in increased expression of CCND2 mRNA CTD PMID:26705709 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCNE2 cyclin E2 increases expression EXP geldanamycin results in increased expression of CCNE2 mRNA CTD PMID:26705709 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CCNK cyclin K increases expression EXP geldanamycin results in increased expression of CCNK mRNA CTD PMID:26705709 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
JBrowse link
G CDC27 cell division cycle 27 increases expression EXP geldanamycin results in increased expression of CDC27 mRNA CTD PMID:26705709 NCBI chr17:47,117,703...47,189,295
Ensembl chr17:47,117,703...47,189,422
JBrowse link
G CDC37 cell division cycle 37, HSP90 cochaperone multiple interactions EXP geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] CTD PMID:17223712 NCBI chr19:10,391,128...10,403,568
Ensembl chr19:10,391,133...10,420,121
JBrowse link
G CDCA2 cell division cycle associated 2 increases expression EXP geldanamycin results in increased expression of CDCA2 mRNA CTD PMID:26705709 NCBI chr 8:25,458,557...25,511,308
Ensembl chr 8:25,459,199...25,507,911
JBrowse link
G CDH1 cadherin 1 multiple interactions
increases expression
EXP geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH4 cadherin 4 increases expression EXP geldanamycin results in increased expression of CDH4 mRNA CTD PMID:26705709 NCBI chr20:61,252,261...61,940,617
Ensembl chr20:61,252,261...61,940,617
JBrowse link
G CDK13 cyclin dependent kinase 13 increases expression EXP geldanamycin results in increased expression of CDK13 mRNA CTD PMID:26705709 NCBI chr 7:39,949,664...40,099,580
Ensembl chr 7:39,950,121...40,099,580
JBrowse link
G CDK14 cyclin dependent kinase 14 increases expression EXP geldanamycin results in increased expression of CDK14 mRNA CTD PMID:26705709 NCBI chr 7:90,596,321...91,210,590
Ensembl chr 7:90,466,424...91,210,590
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 increases expression EXP geldanamycin results in increased expression of CDK6 mRNA CTD PMID:26705709 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CENPJ centromere protein J increases expression EXP geldanamycin results in increased expression of CENPJ mRNA CTD PMID:26705709 NCBI chr13:24,882,279...24,922,889
Ensembl chr13:24,882,279...24,922,889
JBrowse link
G CEP89 centrosomal protein 89 increases expression EXP geldanamycin results in increased expression of CEP89 mRNA CTD PMID:26705709 NCBI chr19:32,875,925...32,972,024
Ensembl chr19:32,875,925...32,971,991
JBrowse link
G CEP95 centrosomal protein 95 increases expression EXP geldanamycin results in increased expression of CEP95 mRNA CTD PMID:26705709 NCBI chr17:64,506,760...64,537,951
Ensembl chr17:64,506,865...64,542,461
JBrowse link
G CERS6 ceramide synthase 6 increases expression EXP geldanamycin results in increased expression of CERS6 mRNA CTD PMID:26705709 NCBI chr 2:168,455,862...168,775,134
Ensembl chr 2:168,456,249...168,775,134
Ensembl chr 2:168,456,249...168,775,134
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex increases degradation EXP geldanamycin results in increased degradation of CHUK protein CTD PMID:15930313 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CLIP1 CAP-Gly domain containing linker protein 1 increases expression EXP geldanamycin results in increased expression of CLIP1 mRNA CTD PMID:26705709 NCBI chr12:122,271,432...122,422,956
Ensembl chr12:122,271,432...122,422,632
JBrowse link
G CLK4 CDC like kinase 4 increases expression EXP geldanamycin results in increased expression of CLK4 mRNA CTD PMID:26705709 NCBI chr 5:178,602,664...178,627,050
Ensembl chr 5:178,602,664...178,630,615
JBrowse link
G COL12A1 collagen type XII alpha 1 chain increases expression EXP geldanamycin results in increased expression of COL12A1 mRNA CTD PMID:26705709 NCBI chr 6:75,084,326...75,206,262
Ensembl chr 6:75,084,326...75,206,053
JBrowse link
G COL25A1 collagen type XXV alpha 1 chain increases expression EXP geldanamycin results in increased expression of COL25A1 mRNA CTD PMID:26705709 NCBI chr 4:108,808,725...109,302,737
Ensembl chr 4:108,808,725...109,302,752
JBrowse link
G COL8A1 collagen type VIII alpha 1 chain increases expression EXP geldanamycin results in increased expression of COL8A1 mRNA CTD PMID:26705709 NCBI chr 3:99,638,594...99,799,217
Ensembl chr 3:99,638,475...99,799,226
JBrowse link
G CPNE3 copine 3 increases expression EXP geldanamycin results in increased expression of CPNE3 mRNA CTD PMID:26705709 NCBI chr 8:86,514,422...86,561,498
Ensembl chr 8:86,514,435...86,561,498
JBrowse link
G CRCP CGRP receptor component increases expression EXP geldanamycin results in increased expression of CRCP mRNA CTD PMID:26705709 NCBI chr 7:66,114,818...66,154,568
Ensembl chr 7:66,114,604...66,154,568
JBrowse link
G CSK C-terminal Src kinase multiple interactions
decreases activity
ISO geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein
CTD PMID:9664232 NCBI chr15:74,782,080...74,803,198
Ensembl chr15:74,782,057...74,803,198
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 increases expression EXP geldanamycin results in increased expression of CSNK2A1 mRNA CTD PMID:26705709 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
JBrowse link
G CTDSPL2 CTD small phosphatase like 2 increases expression EXP geldanamycin results in increased expression of CTDSPL2 mRNA CTD PMID:26705709 NCBI chr15:44,427,329...44,529,038
Ensembl chr15:44,427,622...44,529,038
JBrowse link
G CTNNA1 catenin alpha 1 increases expression EXP geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] CTD PMID:17024233 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CUL5 cullin 5 increases expression EXP geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 NCBI chr11:108,008,733...108,107,766
Ensembl chr11:108,008,898...108,107,761
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein] CTD PMID:11472980 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO geldanamycin results in increased expression of CYP17A1 mRNA CTD PMID:15711029 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO
EXP
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:12237327, PMID:20057149 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 increases expression EXP geldanamycin results in increased expression of DDR2 mRNA CTD PMID:26705709 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405
JBrowse link
G DDX17 DEAD-box helicase 17 increases expression EXP geldanamycin results in increased expression of DDX17 mRNA CTD PMID:26705709 NCBI chr22:38,483,438...38,506,311
Ensembl chr22:38,483,438...38,507,660
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked increases expression EXP geldanamycin results in increased expression of DDX3X mRNA CTD PMID:26705709 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472
Ensembl chr  X:41,333,348...41,364,472
JBrowse link
G DDX42 DEAD-box helicase 42 increases expression EXP geldanamycin results in increased expression of DDX42 mRNA CTD PMID:26705709 NCBI chr17:63,773,856...63,819,317
Ensembl chr17:63,773,603...63,819,317
JBrowse link
G DDX6 DEAD-box helicase 6 increases expression EXP geldanamycin results in increased expression of DDX6 mRNA CTD PMID:26705709 NCBI chr11:118,747,763...118,791,696
Ensembl chr11:118,747,763...118,791,164
JBrowse link
G DHX9 DExH-box helicase 9 increases expression EXP geldanamycin results in increased expression of DHX9 mRNA CTD PMID:26705709 NCBI chr 1:182,839,347...182,887,982
Ensembl chr 1:182,839,347...182,887,982
JBrowse link
G DIP2A disco interacting protein 2 homolog A increases expression EXP geldanamycin results in increased expression of DIP2A mRNA CTD PMID:26705709 NCBI chr21:46,458,891...46,571,226
Ensembl chr21:46,458,891...46,570,015
JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 increases expression EXP geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
JBrowse link
G DMD dystrophin increases expression EXP geldanamycin results in increased expression of DMD mRNA CTD PMID:26705709 NCBI chr  X:31,119,219...33,339,460
Ensembl chr  X:31,097,677...33,339,441
JBrowse link
G DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 increases expression EXP geldanamycin results in increased expression of DNAJC13 mRNA CTD PMID:26705709 NCBI chr 3:132,417,502...132,539,032
Ensembl chr 3:132,417,502...132,539,032
JBrowse link
G DST dystonin increases expression EXP geldanamycin results in increased expression of DST mRNA CTD PMID:26705709 NCBI chr 6:56,457,996...56,954,830
Ensembl chr 6:56,457,987...56,954,649
JBrowse link
G E2F3 E2F transcription factor 3 increases expression EXP geldanamycin results in increased expression of E2F3 mRNA CTD PMID:26705709 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714
JBrowse link
G EDIL3 EGF like repeats and discoidin domains 3 increases expression EXP geldanamycin results in increased expression of EDIL3 mRNA CTD PMID:26705709 NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880
JBrowse link
G EDN1 endothelin 1 increases expression EXP geldanamycin results in increased expression of EDN1 mRNA CTD PMID:26705709 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EEA1 early endosome antigen 1 increases expression EXP geldanamycin results in increased expression of EEA1 mRNA CTD PMID:26705709 NCBI chr12:92,770,637...92,975,228
Ensembl chr12:92,770,637...92,929,331
JBrowse link
G EGF epidermal growth factor multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431, PMID:9664232 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
decreases expression
EXP
ISO
geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein
CTD PMID:9605431, PMID:9664232, PMID:20007406 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EHBP1 EH domain binding protein 1 increases expression EXP geldanamycin results in increased expression of EHBP1 mRNA CTD PMID:26705709 NCBI chr 2:62,673,878...63,046,487
Ensembl chr 2:62,673,851...63,046,487
JBrowse link
G EHMT1 euchromatic histone lysine methyltransferase 1 increases expression EXP geldanamycin results in increased expression of EHMT1 mRNA CTD PMID:26705709 NCBI chr 9:137,619,001...137,836,127
Ensembl chr 9:137,618,992...137,870,016
JBrowse link
G ELL2 elongation factor for RNA polymerase II 2 increases expression EXP geldanamycin results in increased expression of ELL2 mRNA CTD PMID:26705709 NCBI chr 5:95,885,098...95,961,962
Ensembl chr 5:95,885,098...95,961,851
JBrowse link
G EPB41L5 erythrocyte membrane protein band 4.1 like 5 increases expression EXP geldanamycin results in increased expression of EPB41L5 mRNA CTD PMID:26705709 NCBI chr 2:120,013,032...120,179,119
Ensembl chr 2:120,013,077...120,179,119
JBrowse link
G EPRS1 glutamyl-prolyl-tRNA synthetase 1 increases expression EXP geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 NCBI chr 1:219,968,600...220,046,505
Ensembl chr 1:219,968,600...220,046,530
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 increases degradation
multiple interactions
decreases expression
EXP geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein
CTD PMID:8617772, PMID:11071886, PMID:17959518, PMID:18655187, PMID:24450340 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERCC6L2 ERCC excision repair 6 like 2 increases expression EXP geldanamycin results in increased expression of ERCC6L2 mRNA CTD PMID:26705709 NCBI chr 9:95,875,632...96,041,092
Ensembl chr 9:95,871,264...96,121,154
JBrowse link
G ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression EXP geldanamycin results in increased expression of ESCO1 mRNA CTD PMID:26705709 NCBI chr18:21,529,281...21,600,736
Ensembl chr18:21,529,284...21,600,884
JBrowse link
G ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP geldanamycin results in increased expression of ESCO2 mRNA CTD PMID:26705709 NCBI chr 8:27,771,949...27,812,430
Ensembl chr 8:27,771,949...27,812,640
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
decreases stability
increases degradation
EXP geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein
CTD PMID:11448926, PMID:16037132, PMID:24211270 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ETS1 ETS proto-oncogene 1, transcription factor increases expression EXP geldanamycin results in increased expression of ETS1 mRNA CTD PMID:26705709 NCBI chr11:128,458,765...128,587,593
Ensembl chr11:128,458,761...128,587,558
JBrowse link
G EVI5 ecotropic viral integration site 5 increases expression EXP geldanamycin results in increased expression of EVI5 mRNA CTD PMID:26705709 NCBI chr 1:92,508,696...92,792,413
Ensembl chr 1:92,508,696...92,792,404
JBrowse link
G FAM111B family with sequence similarity 111 member B increases expression EXP geldanamycin results in increased expression of FAM111B mRNA CTD PMID:26705709 NCBI chr11:59,107,237...59,127,412
Ensembl chr11:59,107,185...59,127,412
JBrowse link
G FAM126A family with sequence similarity 126 member A increases expression EXP geldanamycin results in increased expression of FAM126A mRNA CTD PMID:26705709 NCBI chr 7:22,895,848...23,014,133
Ensembl chr 7:22,889,371...23,014,130
JBrowse link
G FAM172A family with sequence similarity 172 member A increases expression EXP geldanamycin results in increased expression of FAM172A mRNA CTD PMID:26705709 NCBI chr 5:93,615,130...94,111,699
Ensembl chr 5:93,617,725...94,111,699
JBrowse link
G FANCB FA complementation group B increases expression EXP geldanamycin results in increased expression of FANCB mRNA CTD PMID:26705709 NCBI chr  X:14,690,863...14,873,255
Ensembl chr  X:14,835,961...14,873,069
JBrowse link
G FANCM FA complementation group M increases expression EXP geldanamycin results in increased expression of FANCM mRNA CTD PMID:26705709 NCBI chr14:45,135,930...45,200,890
Ensembl chr14:45,135,930...45,200,890
JBrowse link
G FBN1 fibrillin 1 increases expression EXP geldanamycin results in increased expression of FBN1 mRNA CTD PMID:26705709 NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,306...48,645,849
Ensembl chr15:48,408,306...48,645,849
JBrowse link
G FGF7 fibroblast growth factor 7 multiple interactions EXP
ISO
geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] CTD PMID:14656992 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775
Ensembl chr15:49,423,237...49,488,775
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 increases expression EXP geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FN1 fibronectin 1 increases expression EXP geldanamycin results in increased expression of FN1 mRNA CTD PMID:26705709 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FRYL FRY like transcription coactivator increases expression EXP geldanamycin results in increased expression of FRYL mRNA CTD PMID:26705709 NCBI chr 4:48,497,357...48,780,323
Ensembl chr 4:48,497,357...48,780,322
Ensembl chr 4:48,497,357...48,780,322
JBrowse link
G G3BP1 G3BP stress granule assembly factor 1 increases expression EXP geldanamycin results in increased expression of G3BP1 mRNA CTD PMID:26705709 NCBI chr 5:151,771,954...151,812,785
Ensembl chr 5:151,771,045...151,812,785
JBrowse link
G GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression EXP geldanamycin results in increased expression of GALNT5 mRNA CTD PMID:26705709 NCBI chr 2:157,257,656...157,318,491
Ensembl chr 2:157,257,705...157,318,491
JBrowse link
G GLS glutaminase increases expression EXP geldanamycin results in increased expression of GLS mRNA CTD PMID:26705709 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G GNG12 G protein subunit gamma 12 increases expression EXP geldanamycin results in increased expression of GNG12 mRNA CTD PMID:26705709 NCBI chr 1:67,701,475...67,833,467
Ensembl chr 1:67,701,475...67,833,467
JBrowse link
G GOLIM4 golgi integral membrane protein 4 increases expression EXP geldanamycin results in increased expression of GOLIM4 mRNA CTD PMID:26705709 NCBI chr 3:168,008,672...168,095,924
Ensembl chr 3:168,008,689...168,095,924
JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP geldanamycin results in increased expression of GRIA3 mRNA CTD PMID:26705709 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915
JBrowse link
G GTF2A1 general transcription factor IIA subunit 1 increases expression EXP geldanamycin results in increased expression of GTF2A1 mRNA CTD PMID:26705709 NCBI chr14:81,175,452...81,221,390
Ensembl chr14:81,175,452...81,221,377
JBrowse link
G H1-3 H1.3 linker histone, cluster member increases expression EXP geldanamycin results in increased expression of H1-3 mRNA CTD PMID:26705709 NCBI chr 6:26,234,212...26,234,987
Ensembl chr 6:26,234,268...26,234,933
Ensembl chr 6:26,234,268...26,234,933
JBrowse link
G HACD2 3-hydroxyacyl-CoA dehydratase 2 increases expression EXP geldanamycin results in increased expression of HACD2 mRNA CTD PMID:26705709 NCBI chr 3:123,491,548...123,585,099
Ensembl chr 3:123,490,820...123,585,053
JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 increases expression EXP geldanamycin results in increased expression of HCN1 mRNA CTD PMID:26705709 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498
JBrowse link
G HEATR1 HEAT repeat containing 1 increases expression EXP geldanamycin results in increased expression of HEATR1 mRNA CTD PMID:26705709 NCBI chr 1:236,549,005...236,604,516
Ensembl chr 1:236,549,005...236,604,516
JBrowse link
G HECTD1 HECT domain E3 ubiquitin protein ligase 1 increases expression EXP geldanamycin results in increased expression of HECTD1 mRNA CTD PMID:26705709 NCBI chr14:31,100,117...31,207,793
Ensembl chr14:31,100,112...31,207,804
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases degradation
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein
CTD PMID:11980636, PMID:12811834, PMID:14726529, PMID:15319539, PMID:16432534 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein] CTD PMID:25645596 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase multiple interactions EXP geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] CTD PMID:15680906 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154
JBrowse link
G HSF1 heat shock transcription factor 1 multiple interactions EXP geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574, PMID:25645596 NCBI chr 8:144,291,603...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 affects binding
multiple interactions
ISO
EXP
geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]
CTD PMID:12775586, PMID:17223712, PMID:18655187, PMID:21749116 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 affects binding
increases expression
ISO
EXP
geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA
CTD PMID:21749116, PMID:26705709 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 affects binding
multiple interactions
EXP geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]
CTD PMID:8617772 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO
EXP
geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins
CTD PMID:11448926, PMID:19723345, PMID:25477506 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
EXP geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509, PMID:26705709 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
affects expression
EXP Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein
CTD PMID:14576064, PMID:15141013 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP geldanamycin results in increased expression of HSPD1 mRNA CTD PMID:26705709 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G HTT huntingtin multiple interactions EXP geldanamycin inhibits the reaction [HTT protein binds to HTT protein] CTD PMID:11406612 NCBI chr 4:3,074,681...3,243,960
Ensembl chr 4:3,041,422...3,243,960
JBrowse link
G ICE2 interactor of little elongation complex ELL subunit 2 increases expression EXP geldanamycin results in increased expression of ICE2 mRNA CTD PMID:26705709 NCBI chr15:60,419,609...60,479,142
Ensembl chr15:60,419,609...60,479,160
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]
CTD PMID:12571865, PMID:15808840 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL24 interleukin 24 multiple interactions EXP IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr 1:206,897,404...206,904,139
Ensembl chr 1:206,897,443...206,904,139
JBrowse link
G IL6 interleukin 6 multiple interactions ISO geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] CTD PMID:12571865 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6ST interleukin 6 signal transducer increases expression EXP geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022
JBrowse link
G INHBA inhibin subunit beta A increases expression EXP geldanamycin results in increased expression of INHBA mRNA CTD PMID:26705709 NCBI chr 7:41,685,101...41,710,532
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G INPP5A inositol polyphosphate-5-phosphatase A increases expression EXP geldanamycin results in increased expression of INPP5A mRNA CTD PMID:26705709 NCBI chr10:132,537,784...132,783,480
Ensembl chr10:132,537,787...132,783,480
JBrowse link
G IPO8 importin 8 increases expression EXP geldanamycin results in increased expression of IPO8 mRNA CTD PMID:26705709 NCBI chr12:30,628,981...30,695,986
Ensembl chr12:30,628,988...30,695,869
JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 increases expression EXP geldanamycin results in increased expression of IQGAP1 mRNA CTD PMID:26705709 NCBI chr15:90,388,242...90,502,239
Ensembl chr15:90,388,242...90,502,239
JBrowse link
G ITGA1 integrin subunit alpha 1 increases expression EXP geldanamycin results in increased expression of ITGA1 mRNA CTD PMID:26705709 NCBI chr 5:52,787,916...52,959,209
Ensembl chr 5:52,787,916...52,959,209
JBrowse link
G ITGB3 integrin subunit beta 3 increases expression EXP geldanamycin results in increased expression of ITGB3 mRNA CTD PMID:26705709 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
JBrowse link
G ITPRID2 ITPR interacting domain containing 2 increases expression EXP geldanamycin results in increased expression of ITPRID2 mRNA CTD PMID:26705709 NCBI chr 2:181,891,730...181,930,738
Ensembl chr 2:181,891,730...181,930,738
JBrowse link
G JMJD1C jumonji domain containing 1C increases expression EXP geldanamycin results in increased expression of JMJD1C mRNA CTD PMID:26705709 NCBI chr10:63,167,221...63,521,890
Ensembl chr10:63,167,221...63,521,850
JBrowse link
G KAT6A lysine acetyltransferase 6A increases expression EXP geldanamycin results in increased expression of KAT6A mRNA CTD PMID:26705709 NCBI chr 8:41,929,479...42,051,988
Ensembl chr 8:41,929,479...42,051,994
JBrowse link
G KBTBD2 kelch repeat and BTB domain containing 2 increases expression EXP geldanamycin results in increased expression of KBTBD2 mRNA CTD PMID:26705709 NCBI chr 7:32,868,172...32,892,144
Ensembl chr 7:32,868,172...32,894,131
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 affects localization
decreases activity
increases degradation
multiple interactions
decreases expression
EXP geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586, PMID:24052561 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KDM6A lysine demethylase 6A increases expression EXP geldanamycin results in increased expression of KDM6A mRNA CTD PMID:26705709 NCBI chr  X:44,873,182...45,112,779
Ensembl chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
JBrowse link
G KIAA0100 KIAA0100 increases expression EXP geldanamycin results in increased expression of KIAA0100 mRNA CTD PMID:26705709 NCBI chr17:28,614,440...28,645,159
Ensembl chr17:28,614,446...28,645,454
JBrowse link
G KIRREL1 kirre like nephrin family adhesion molecule 1 increases expression EXP geldanamycin results in increased expression of KIRREL1 mRNA CTD PMID:26705709 NCBI chr 1:157,993,613...158,100,262
Ensembl chr 1:157,993,273...158,100,262
JBrowse link
G KLF12 Kruppel like factor 12 increases expression EXP geldanamycin results in increased expression of KLF12 mRNA CTD PMID:26705709 NCBI chr13:73,686,089...74,168,295
Ensembl chr13:73,686,089...73,995,056
JBrowse link
G KLHL24 kelch like family member 24 increases expression EXP geldanamycin results in increased expression of KLHL24 mRNA CTD PMID:26705709 NCBI chr 3:183,635,619...183,684,519
Ensembl chr 3:183,635,610...183,684,519
JBrowse link
G KMT2A lysine methyltransferase 2A increases expression EXP geldanamycin results in increased expression of KMT2A mRNA CTD PMID:26705709 NCBI chr11:118,436,492...118,526,832
Ensembl chr11:118,436,490...118,526,832
JBrowse link
G KNL1 kinetochore scaffold 1 increases expression EXP geldanamycin results in increased expression of KNL1 mRNA CTD PMID:26705709 NCBI chr15:40,594,012...40,664,342
Ensembl chr15:40,594,020...40,664,342
JBrowse link
G LAMA4 laminin subunit alpha 4 increases expression EXP geldanamycin results in increased expression of LAMA4 mRNA CTD PMID:26705709 NCBI chr 6:112,107,931...112,254,722
Ensembl chr 6:112,107,931...112,254,939
JBrowse link
G LARP1B La ribonucleoprotein 1B increases expression EXP geldanamycin results in increased expression of LARP1B mRNA CTD PMID:26705709 NCBI chr 4:128,060,655...128,222,931
Ensembl chr 4:128,061,286...128,222,931
JBrowse link
G LARP4 La ribonucleoprotein 4 increases expression EXP geldanamycin results in increased expression of LARP4 mRNA CTD PMID:26705709 NCBI chr12:50,400,862...50,480,004
Ensembl chr12:50,392,383...50,480,004
JBrowse link
G LARS1 leucyl-tRNA synthetase 1 increases expression EXP geldanamycin results in increased expression of LARS1 mRNA CTD PMID:26705709 NCBI chr 5:146,113,034...146,182,731
Ensembl chr 5:146,113,034...146,182,650
Ensembl chr 5:146,113,034...146,182,650
JBrowse link
G LIMA1 LIM domain and actin binding 1 increases expression EXP geldanamycin results in increased expression of LIMA1 mRNA CTD PMID:26705709 NCBI chr12:50,175,780...50,283,520
Ensembl chr12:50,175,788...50,283,546
JBrowse link
G LIN7A lin-7 homolog A, crumbs cell polarity complex component increases expression EXP geldanamycin results in increased expression of LIN7A mRNA CTD PMID:26705709 NCBI chr12:80,792,520...80,937,934
Ensembl chr12:80,792,520...80,937,925
JBrowse link
G LINC00968 long intergenic non-protein coding RNA 968 increases expression EXP geldanamycin results in increased expression of LINC00968 mRNA CTD PMID:26705709 NCBI chr 8:56,518,318...56,559,823
Ensembl chr 8:56,496,048...56,559,823
JBrowse link
G LMAN1 lectin, mannose binding 1 increases expression EXP geldanamycin results in increased expression of LMAN1 mRNA CTD PMID:26705709 NCBI chr18:59,327,823...59,359,265
Ensembl chr18:59,327,823...59,359,265
JBrowse link
G LMO7 LIM domain 7 increases expression EXP geldanamycin results in increased expression of LMO7 mRNA CTD PMID:26705709 NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870
JBrowse link
G LPP LIM domain containing preferred translocation partner in lipoma increases expression EXP geldanamycin results in increased expression of LPP mRNA CTD PMID:26705709 NCBI chr 3:188,152,152...188,890,671
Ensembl chr 3:188,153,284...188,890,671
JBrowse link
G LRRC58 leucine rich repeat containing 58 increases expression EXP geldanamycin results in increased expression of LRRC58 mRNA CTD PMID:26705709 NCBI chr 3:120,324,509...120,349,354
Ensembl chr 3:120,324,509...120,349,354
JBrowse link
G LSM14B LSM family member 14B increases expression EXP geldanamycin results in increased expression of LSM14B mRNA CTD PMID:26705709 NCBI chr20:62,122,454...62,135,378
Ensembl chr20:62,122,461...62,135,374
JBrowse link
G MALAT1 metastasis associated lung adenocarcinoma transcript 1 increases expression EXP geldanamycin results in increased expression of MALAT1 mRNA CTD PMID:26705709 NCBI chr11:65,497,738...65,506,516
Ensembl chr11:65,497,688...65,506,516
JBrowse link
G MAN1A2 mannosidase alpha class 1A member 2 increases expression EXP geldanamycin results in increased expression of MAN1A2 mRNA CTD PMID:26705709 NCBI chr 1:117,367,393...117,528,872
Ensembl chr 1:117,367,449...117,528,872
JBrowse link
G MAP1B microtubule associated protein 1B increases expression EXP geldanamycin results in increased expression of MAP1B mRNA CTD PMID:26705709 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein
CTD PMID:8816498, PMID:19167484 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 decreases phosphorylation EXP geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,129
Ensembl chr19:4,090,321...4,124,129
JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP geldanamycin results in increased expression of MAP3K1 mRNA CTD PMID:26705709 NCBI chr 5:56,815,543...56,896,152
Ensembl chr 5:56,815,549...56,896,152
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 increases expression EXP geldanamycin results in increased expression of MAP3K5 mRNA CTD PMID:26705709 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 increases expression EXP geldanamycin results in increased expression of MAP4K5 mRNA CTD PMID:26705709 NCBI chr14:50,418,492...50,561,126
Ensembl chr14:50,418,501...50,561,126
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
EXP
ISO
geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:8816498, PMID:15888667, PMID:17293044, PMID:19167484, PMID:30166341 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:8816498, PMID:15888667, PMID:17293044, PMID:19167484 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 increases expression EXP geldanamycin results in increased expression of MAPKAPK2 mRNA CTD PMID:26705709 NCBI chr 1:206,684,905...206,734,283
Ensembl chr 1:206,684,944...206,734,283
Ensembl chr 1:206,684,944...206,734,283
JBrowse link
G MATR3 matrin 3 increases expression EXP geldanamycin results in increased expression of MATR3 mRNA CTD PMID:26705709 NCBI chr 5:139,274,101...139,331,677
Ensembl chr 5:139,273,752...139,331,671
Ensembl chr 5:139,273,752...139,331,671
JBrowse link
G MBNL1 muscleblind like splicing regulator 1 increases expression EXP geldanamycin results in increased expression of MBNL1 mRNA CTD PMID:26705709 NCBI chr 3:152,243,632...152,465,780
Ensembl chr 3:152,243,828...152,465,780
JBrowse link
G MBNL2 muscleblind like splicing regulator 2 increases expression EXP geldanamycin results in increased expression of MBNL2 mRNA CTD PMID:26705709 NCBI chr13:97,141,834...97,394,120
Ensembl chr13:97,221,434...97,394,120
JBrowse link
G MBTD1 mbt domain containing 1 increases expression EXP geldanamycin results in increased expression of MBTD1 mRNA CTD PMID:26705709 NCBI chr17:51,177,419...51,260,511
Ensembl chr17:51,177,425...51,260,163
JBrowse link
G MCAM melanoma cell adhesion molecule increases expression EXP geldanamycin results in increased expression of MCAM mRNA CTD PMID:26705709 NCBI chr11:119,305,759...119,317,130
Ensembl chr11:119,308,529...119,321,521
JBrowse link
G MCM4 minichromosome maintenance complex component 4 increases expression EXP geldanamycin results in increased expression of MCM4 mRNA CTD PMID:26705709 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MDFIC MyoD family inhibitor domain containing increases expression EXP geldanamycin results in increased expression of MDFIC mRNA CTD PMID:26705709 NCBI chr 7:114,922,154...115,019,916
Ensembl chr 7:114,922,359...115,019,202
Ensembl chr 7:114,922,359...115,019,202
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MED13 mediator complex subunit 13 increases expression EXP geldanamycin results in increased expression of MED13 mRNA CTD PMID:26705709 NCBI chr17:61,942,605...62,065,983
Ensembl chr17:61,942,605...62,065,278
JBrowse link
G MED7 mediator complex subunit 7 increases expression EXP geldanamycin results in increased expression of MED7 mRNA CTD PMID:26705709 NCBI chr 5:157,137,424...157,142,865
Ensembl chr 5:157,137,424...157,159,019
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase increases expression EXP geldanamycin results in increased expression of MET mRNA CTD PMID:26705709 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
JBrowse link
G METTL16 methyltransferase like 16 increases expression EXP geldanamycin results in increased expression of METTL16 mRNA CTD PMID:26705709 NCBI chr17:2,416,049...2,511,901
Ensembl chr17:2,405,562...2,511,891
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase multiple interactions EXP geldanamycin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MIER1 MIER1 transcriptional regulator increases expression EXP geldanamycin results in increased expression of MIER1 mRNA CTD PMID:26705709 NCBI chr 1:66,924,900...66,988,619
Ensembl chr 1:66,924,895...66,988,619
JBrowse link
G MIR21 microRNA 21 increases expression EXP geldanamycin results in increased expression of MIR21 mRNA CTD PMID:26705709 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIS18BP1 MIS18 binding protein 1 increases expression EXP geldanamycin results in increased expression of MIS18BP1 mRNA CTD PMID:26705709 NCBI chr14:45,203,190...45,257,190
Ensembl chr14:45,203,190...45,253,540
JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions
decreases expression
EXP [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA
CTD PMID:12724357, PMID:26705709 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MMP16 matrix metallopeptidase 16 increases expression EXP geldanamycin results in increased expression of MMP16 mRNA CTD PMID:26705709 NCBI chr 8:88,032,009...88,327,483
Ensembl chr 8:88,032,011...88,328,025
JBrowse link
G MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 increases expression EXP geldanamycin results in increased expression of ND6 mRNA CTD PMID:26705709 NCBI chr MT:14,149...14,673
Ensembl chr MT:14,149...14,673
JBrowse link
G MYO5A myosin VA increases expression EXP geldanamycin results in increased expression of MYO5A mRNA CTD PMID:26705709 NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,283...52,529,050
JBrowse link
G MYOCD myocardin increases expression EXP geldanamycin results in increased expression of MYOCD mRNA CTD PMID:26705709 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949
JBrowse link
G MZT1 mitotic spindle organizing protein 1 increases expression EXP geldanamycin results in increased expression of MZT1 mRNA CTD PMID:26705709 NCBI chr13:72,708,367...72,727,629
Ensembl chr13:72,708,367...72,727,629
JBrowse link
G NASP nuclear autoantigenic sperm protein increases expression EXP geldanamycin results in increased expression of NASP mRNA CTD PMID:26705709 NCBI chr 1:45,584,041...45,618,893
Ensembl chr 1:45,583,846...45,618,904
JBrowse link
G NBAS NBAS subunit of NRZ tethering complex increases expression EXP geldanamycin results in increased expression of NBAS mRNA CTD PMID:26705709 NCBI chr 2:14,998,067...15,561,344
Ensembl chr 2:15,166,914...15,561,334
JBrowse link
G NCOA2 nuclear receptor coactivator 2 increases expression EXP geldanamycin results in increased expression of NCOA2 mRNA CTD PMID:26705709 NCBI chr 8:70,109,770...70,405,390
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 increases expression EXP geldanamycin results in increased expression of NEDD9 mRNA CTD PMID:26705709 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348
JBrowse link
G NES nestin increases expression EXP geldanamycin results in increased expression of NES mRNA CTD PMID:26705709 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
JBrowse link
G NF1 neurofibromin 1 increases expression EXP geldanamycin results in increased expression of NF1 mRNA CTD PMID:26705709 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116
JBrowse link
G NF2 neurofibromin 2 increases expression EXP geldanamycin results in increased expression of NF2 mRNA CTD PMID:26705709 NCBI chr22:29,603,556...29,698,600
Ensembl chr22:29,603,556...29,698,598
JBrowse link
G NFAT5 nuclear factor of activated T cells 5 increases expression EXP geldanamycin results in increased expression of NFAT5 mRNA CTD PMID:26705709 NCBI chr16:69,565,952...69,704,654
Ensembl chr16:69,565,094...69,704,666
JBrowse link
G NIPBL NIPBL cohesin loading factor increases expression EXP geldanamycin results in increased expression of NIPBL mRNA CTD PMID:26705709 NCBI chr 5:36,876,769...37,066,413
Ensembl chr 5:36,876,769...37,066,413
JBrowse link
G NKTR natural killer cell triggering receptor increases expression EXP geldanamycin results in increased expression of NKTR mRNA CTD PMID:26705709 NCBI chr 3:42,600,007...42,648,735
Ensembl chr 3:42,600,655...42,648,735
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313, PMID:15583003 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPR3 natriuretic peptide receptor 3 increases expression EXP geldanamycin results in increased expression of NPR3 mRNA CTD PMID:26705709 NCBI chr 5:32,689,076...32,791,720
Ensembl chr 5:32,689,070...32,791,724
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases reduction EXP NQO1 protein results in increased reduction of geldanamycin CTD PMID:16825487 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR2C2 nuclear receptor subfamily 2 group C member 2 increases expression EXP geldanamycin results in increased expression of NR2C2 mRNA CTD PMID:26705709 NCBI chr 3:14,947,583...15,049,273
Ensembl chr 3:14,947,584...15,053,600
JBrowse link
G NRK Nik related kinase increases expression EXP geldanamycin results in increased expression of NRK mRNA CTD PMID:26705709 NCBI chr  X:105,821,942...105,958,610
Ensembl chr  X:105,822,539...105,958,610
JBrowse link
G OSBPL8 oxysterol binding protein like 8 increases expression EXP geldanamycin results in increased expression of OSBPL8 mRNA CTD PMID:26705709 NCBI chr12:76,351,797...76,559,805
Ensembl chr12:76,351,797...76,559,809
JBrowse link
G OTUD4 OTU deubiquitinase 4 increases expression EXP geldanamycin results in increased expression of OTUD4 mRNA CTD PMID:26705709 NCBI chr 4:145,133,650...145,180,589
Ensembl chr 4:145,110,838...145,180,589
JBrowse link
G OXTR oxytocin receptor increases expression EXP geldanamycin results in increased expression of OXTR mRNA CTD PMID:26705709 NCBI chr 3:8,750,381...8,769,613
Ensembl chr 3:8,750,408...8,769,628
JBrowse link
G P2RX1 purinergic receptor P2X 1 multiple interactions ISO geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr17:3,896,591...3,916,506
Ensembl chr17:3,896,592...3,916,476
JBrowse link
G PAPPA pappalysin 1 increases expression EXP geldanamycin results in increased expression of PAPPA mRNA CTD PMID:26705709 NCBI chr 9:116,153,752...116,402,321
Ensembl chr 9:116,153,791...116,402,321
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases degradation
EXP geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509, PMID:17293044 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCBP2 poly(rC) binding protein 2 increases expression EXP geldanamycin results in increased expression of PCBP2 mRNA CTD PMID:26705709 NCBI chr12:53,452,102...53,481,162
Ensembl chr12:53,452,102...53,481,162
JBrowse link
G PCM1 pericentriolar material 1 increases expression EXP geldanamycin results in increased expression of PCM1 mRNA CTD PMID:26705709 NCBI chr 8:17,922,784...18,029,948
Ensembl chr 8:17,922,840...18,027,975
Ensembl chr 8:17,922,840...18,027,975
JBrowse link
G PDE4DIP phosphodiesterase 4D interacting protein increases expression EXP geldanamycin results in increased expression of PDE4DIP mRNA CTD PMID:26705709 NCBI chr 1:148,808,198...149,051,277
Ensembl chr 1:148,808,181...149,048,286
JBrowse link
G PDGFA platelet derived growth factor subunit A increases expression EXP geldanamycin results in increased expression of PDGFA mRNA CTD PMID:26705709 NCBI chr 7:497,245...520,668
Ensembl chr 7:497,258...520,296
JBrowse link
G PEG10 paternally expressed 10 increases expression EXP geldanamycin results in increased expression of PEG10 mRNA CTD PMID:26705709 NCBI chr 7:94,656,325...94,669,695
Ensembl chr 7:94,656,325...94,669,695
JBrowse link
G PGR progesterone receptor decreases expression EXP geldanamycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PHACTR2 phosphatase and actin regulator 2 increases expression EXP geldanamycin results in increased expression of PHACTR2 mRNA CTD PMID:26705709 NCBI chr 6:143,608,180...143,831,185
Ensembl chr 6:143,536,845...143,831,185
JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 increases expression EXP geldanamycin results in increased expression of PHLDB2 mRNA CTD PMID:26705709 NCBI chr 3:111,732,496...111,976,517
Ensembl chr 3:111,732,497...111,976,517
JBrowse link
G PHTF2 putative homeodomain transcription factor 2 increases expression EXP geldanamycin results in increased expression of PHTF2 mRNA CTD PMID:26705709 NCBI chr 7:77,798,773...77,957,504
Ensembl chr 7:77,798,792...77,957,503
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha increases expression EXP geldanamycin results in increased expression of PIK3CA mRNA CTD PMID:26705709 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA CTD PMID:12724357 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLPPR4 phospholipid phosphatase related 4 increases expression EXP geldanamycin results in increased expression of PLPPR4 mRNA CTD PMID:26705709 NCBI chr 1:99,262,956...99,309,584
Ensembl chr 1:99,263,953...99,309,590
JBrowse link
G PLXNA2 plexin A2 increases expression EXP geldanamycin results in increased expression of PLXNA2 mRNA CTD PMID:26705709 NCBI chr 1:208,022,242...208,244,384
Ensembl chr 1:208,022,242...208,244,384
JBrowse link
G POLR2B RNA polymerase II subunit B decreases expression EXP geldanamycin results in decreased expression of POLR2B mRNA CTD PMID:30166341 NCBI chr 4:56,978,896...57,031,158
Ensembl chr 4:56,977,722...57,031,158
JBrowse link
G PPM1K protein phosphatase, Mg2+/Mn2+ dependent 1K increases expression EXP geldanamycin results in increased expression of PPM1K mRNA CTD PMID:26705709 NCBI chr 4:88,257,617...88,284,670
Ensembl chr 4:88,257,620...88,284,769
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 increases expression EXP geldanamycin results in increased expression of PRKG1 mRNA CTD PMID:26705709 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G PRMT2 protein arginine methyltransferase 2 increases expression EXP geldanamycin results in increased expression of PRMT2 mRNA CTD PMID:26705709 NCBI chr21:46,635,156...46,665,685
Ensembl chr21:46,635,595...46,665,124
JBrowse link
G PRPF6 pre-mRNA processing factor 6 increases expression EXP geldanamycin results in increased expression of PRPF6 mRNA CTD PMID:26705709 NCBI chr20:63,981,132...64,033,100
Ensembl chr20:63,981,132...64,033,100
JBrowse link
G PRR14L proline rich 14 like increases expression EXP geldanamycin results in increased expression of PRR14L mRNA CTD PMID:26705709 NCBI chr22:31,681,347...31,750,132
Ensembl chr22:31,676,256...31,750,140
JBrowse link
G PRRC2C proline rich coiled-coil 2C increases expression EXP geldanamycin results in increased expression of PRRC2C mRNA CTD PMID:26705709 NCBI chr 1:171,485,496...171,593,511
Ensembl chr 1:171,485,551...171,593,511
JBrowse link
G PSME4 proteasome activator subunit 4 increases expression EXP geldanamycin results in increased expression of PSME4 mRNA CTD PMID:26705709 NCBI chr 2:53,864,069...53,970,993
Ensembl chr 2:53,864,069...53,970,993
JBrowse link
G PTAR1 protein prenyltransferase alpha subunit repeat containing 1 increases expression EXP geldanamycin results in increased expression of PTAR1 mRNA CTD PMID:26705709 NCBI chr 9:69,709,525...69,760,044
Ensembl chr 9:69,709,522...69,760,011
JBrowse link
G PTBP3 polypyrimidine tract binding protein 3 increases expression EXP geldanamycin results in increased expression of PTBP3 mRNA CTD PMID:26705709 NCBI chr 9:112,217,715...112,333,669
Ensembl chr 9:112,217,716...112,333,664
Ensembl chr 9:112,217,716...112,333,664
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression EXP geldanamycin results in decreased expression of PTGS1 mRNA CTD PMID:26705709 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:11133817 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTHLH parathyroid hormone like hormone multiple interactions EXP [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 NCBI chr12:27,958,084...27,972,864
Ensembl chr12:27,958,084...27,972,733
JBrowse link
G PTK2 protein tyrosine kinase 2 increases degradation
decreases phosphorylation
EXP
ISO
geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein
CTD PMID:9973544, PMID:12811834 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 increases expression EXP geldanamycin results in increased expression of PTPN11 mRNA CTD PMID:26705709 NCBI chr12:112,418,915...112,509,918
Ensembl chr12:112,418,351...112,509,913
Ensembl chr12:112,418,351...112,509,913
JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 increases expression EXP geldanamycin results in increased expression of PTPN12 mRNA CTD PMID:26705709 NCBI chr 7:77,537,190...77,640,069
Ensembl chr 7:77,537,295...77,640,069
JBrowse link
G PTPRA protein tyrosine phosphatase receptor type A increases expression EXP geldanamycin results in increased expression of PTPRA mRNA CTD PMID:26705709 NCBI chr20:2,864,184...3,038,669
Ensembl chr20:2,864,184...3,039,076
JBrowse link
G PTPRD protein tyrosine phosphatase receptor type D increases expression EXP geldanamycin results in increased expression of PTPRD mRNA CTD PMID:26705709 NCBI chr 9:8,314,246...10,613,002
Ensembl chr 9:8,314,246...10,612,723
JBrowse link
G PWAR5 Prader Willi/Angelman region RNA 5 increases expression EXP geldanamycin results in increased expression of PWAR5 mRNA CTD PMID:26705709 NCBI chr15:24,984,860...24,988,232
Ensembl chr15:24,985,053...24,988,232
JBrowse link
G PYGO1 pygopus family PHD finger 1 increases expression EXP geldanamycin results in increased expression of PYGO1 mRNA CTD PMID:26705709 NCBI chr15:55,538,884...55,588,971
Ensembl chr15:55,538,890...55,588,947
JBrowse link
G RAB3B RAB3B, member RAS oncogene family increases expression EXP geldanamycin results in increased expression of RAB3B mRNA CTD PMID:26705709 NCBI chr 1:51,907,956...51,990,700
Ensembl chr 1:51,907,956...51,990,700
JBrowse link
G RABEP1 rabaptin, RAB GTPase binding effector protein 1 increases expression EXP geldanamycin results in increased expression of RABEP1 mRNA CTD PMID:26705709 NCBI chr17:5,282,272...5,386,340
Ensembl chr17:5,282,265...5,386,340
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
decreases expression
multiple interactions
ISO
EXP
geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein
CTD PMID:8816498, PMID:19167484, PMID:24450340 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,226
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 increases expression EXP geldanamycin results in increased expression of RAPGEF2 mRNA CTD PMID:26705709 NCBI chr 4:159,104,051...159,360,169
Ensembl chr 4:159,103,013...159,360,174
JBrowse link
G RASSF8 Ras association domain family member 8 increases expression EXP geldanamycin results in increased expression of RASSF8 mRNA CTD PMID:26705709 NCBI chr12:25,958,232...26,079,889
Ensembl chr12:25,959,029...26,079,892
JBrowse link
G RBAK RB associated KRAB zinc finger increases expression EXP geldanamycin results in increased expression of RBAK mRNA CTD PMID:26705709 NCBI chr 7:5,045,860...5,069,487
Ensembl chr 7:5,045,821...5,069,487
JBrowse link
G RBM26 RNA binding motif protein 26 increases expression EXP geldanamycin results in increased expression of RBM26 mRNA CTD PMID:26705709 NCBI chr13:79,311,827...79,406,255
Ensembl chr13:79,311,824...79,406,477
JBrowse link
G RBMS3 RNA binding motif single stranded interacting protein 3 increases expression EXP geldanamycin results in increased expression of RBMS3 mRNA CTD PMID:26705709 NCBI chr 3:29,280,860...30,010,395
Ensembl chr 3:28,574,791...30,010,391
JBrowse link
G RCAN1 regulator of calcineurin 1 increases expression EXP geldanamycin results in increased expression of RCAN1 mRNA CTD PMID:26705709 NCBI chr21:34,516,442...34,615,123
Ensembl chr21:34,513,142...34,615,113
JBrowse link
G RDH10 retinol dehydrogenase 10 increases expression EXP geldanamycin results in increased expression of RDH10 mRNA CTD PMID:26705709 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281
JBrowse link
G RESF1 retroelement silencing factor 1 increases expression EXP geldanamycin results in increased expression of RESF1 mRNA CTD PMID:26705709 NCBI chr12:31,959,415...31,993,107
Ensembl chr12:31,959,370...31,993,107
JBrowse link
G RFX7 regulatory factor X7 increases expression EXP geldanamycin results in increased expression of RFX7 mRNA CTD PMID:26705709 NCBI chr15:56,087,280...56,247,654
Ensembl chr15:56,087,280...56,245,082
Ensembl chr15:56,087,280...56,245,082
JBrowse link
G RNGTT RNA guanylyltransferase and 5'-phosphatase increases expression
decreases expression
EXP geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein
CTD PMID:26705709, PMID:30166341 NCBI chr 6:88,609,897...88,963,618
Ensembl chr 6:88,609,897...88,963,618
JBrowse link
G RO60 Ro60, Y RNA binding protein increases expression EXP geldanamycin results in increased expression of RO60 mRNA CTD PMID:26705709 NCBI chr 1:193,059,454...193,091,777
Ensembl chr 1:193,059,454...193,091,777
Ensembl chr 1:193,059,454...193,091,777
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 increases expression EXP geldanamycin results in increased expression of ROCK2 mRNA CTD PMID:26705709 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330
JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 decreases expression EXP geldanamycin results in decreased expression of RPLP0 mRNA CTD PMID:30166341 NCBI chr12:120,196,699...120,201,111
Ensembl chr12:120,196,699...120,201,235
JBrowse link
G RTTN rotatin increases expression EXP geldanamycin results in increased expression of RTTN mRNA CTD PMID:26705709 NCBI chr18:70,003,031...70,205,726
Ensembl chr18:70,003,031...70,205,726
JBrowse link
G RUFY2 RUN and FYVE domain containing 2 increases expression EXP geldanamycin results in increased expression of RUFY2 mRNA CTD PMID:26705709 NCBI chr10:68,341,112...68,407,302
Ensembl chr10:68,341,107...68,407,294
JBrowse link
G S100A4 S100 calcium binding protein A4 decreases expression EXP geldanamycin results in decreased expression of S100A4 mRNA CTD PMID:26705709 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G SAMD5 sterile alpha motif domain containing 5 increases expression EXP geldanamycin results in increased expression of SAMD5 mRNA CTD PMID:26705709 NCBI chr 6:147,508,690...147,948,291
Ensembl chr 6:147,508,690...147,737,547
JBrowse link
G SAR1B secretion associated Ras related GTPase 1B increases expression EXP geldanamycin results in increased expression of SAR1B mRNA CTD PMID:26705709 NCBI chr 5:134,601,149...134,632,828
Ensembl chr 5:134,601,149...134,649,271
JBrowse link
G SCRN3 secernin 3 increases expression EXP geldanamycin results in increased expression of SCRN3 mRNA CTD PMID:26705709 NCBI chr 2:174,395,730...174,430,074
Ensembl chr 2:174,395,730...174,429,575
JBrowse link
G SCYL2 SCY1 like pseudokinase 2 increases expression EXP geldanamycin results in increased expression of SCYL2 mRNA CTD PMID:26705709 NCBI chr12:100,267,177...100,341,715
Ensembl chr12:100,267,140...100,341,715
JBrowse link
G SEMA3D semaphorin 3D increases expression EXP geldanamycin results in increased expression of SEMA3D mRNA CTD PMID:26705709 NCBI chr 7:84,995,192...85,250,243
Ensembl chr 7:84,995,553...85,186,855
JBrowse link
G SENP1 SUMO specific peptidase 1 increases expression EXP geldanamycin results in increased expression of SENP1 mRNA CTD PMID:26705709 NCBI chr12:48,042,893...48,106,308
Ensembl chr12:48,042,897...48,106,079
JBrowse link
G SEPTIN7P2 septin 7 pseudogene 2 increases expression EXP geldanamycin results in increased expression of SEPTIN7P2 mRNA CTD PMID:26705709 NCBI chr 7:45,723,787...45,769,018
Ensembl chr 7:45,723,780...45,768,985
JBrowse link
G SERPINE1 serpin family E member 1 increases expression EXP geldanamycin results in increased expression of SERPINE1 mRNA CTD PMID:26705709 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SESN3 sestrin 3 increases expression EXP geldanamycin results in increased expression of SESN3 mRNA CTD PMID:26705709 NCBI chr11:95,165,513...95,232,536
Ensembl chr11:95,165,513...95,232,541
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase increases expression EXP geldanamycin results in increased expression of SETD2 mRNA CTD PMID:26705709 NCBI chr 3:47,016,431...47,164,113
Ensembl chr 3:47,016,429...47,164,113
Ensembl chr 3:47,016,429...47,164,113
JBrowse link
G SETX senataxin increases expression EXP geldanamycin results in increased expression of SETX mRNA CTD PMID:26705709 NCBI chr 9:132,261,356...132,356,726
Ensembl chr 9:132,261,356...132,354,986
JBrowse link
G SFPQ splicing factor proline and glutamine rich increases expression EXP geldanamycin results in increased expression of SFPQ mRNA CTD PMID:26705709 NCBI chr 1:35,176,380...35,193,174
Ensembl chr 1:35,176,378...35,193,145
JBrowse link
G SGMS2 sphingomyelin synthase 2 increases expression EXP geldanamycin results in increased expression of SGMS2 mRNA CTD PMID:26705709 NCBI chr 4:107,823,645...107,915,047
Ensembl chr 4:107,824,563...107,915,047
JBrowse link
G SIKE1 suppressor of IKBKE 1 increases expression EXP geldanamycin results in increased expression of SIKE1 mRNA CTD PMID:26705709 NCBI chr 1:114,769,479...114,780,685
Ensembl chr 1:114,769,479...114,780,685
JBrowse link
G SLAIN2 SLAIN motif family member 2 increases expression EXP geldanamycin results in increased expression of SLAIN2 mRNA CTD PMID:26705709 NCBI chr 4:48,341,475...48,426,201
Ensembl chr 4:48,341,529...48,426,201
JBrowse link
G SLC16A1 solute carrier family 16 member 1 increases expression EXP geldanamycin results in increased expression of SLC16A1 mRNA CTD PMID:26705709 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013
JBrowse link
G SLC16A7 solute carrier family 16 member 7 increases expression EXP geldanamycin results in increased expression of SLC16A7 mRNA CTD PMID:26705709 NCBI chr12:59,595,934...59,789,841
Ensembl chr12:59,596,029...59,789,855
JBrowse link
G SLC2A13 solute carrier family 2 member 13 increases expression EXP geldanamycin results in increased expression of SLC2A13 mRNA CTD PMID:26705709 NCBI chr12:39,755,021...40,106,085
Ensembl chr12:39,755,025...40,106,089
JBrowse link
G SLC38A1 solute carrier family 38 member 1 increases expression EXP geldanamycin results in increased expression of SLC38A1 mRNA CTD PMID:26705709 NCBI chr12:46,183,063...46,269,149
Ensembl chr12:46,183,063...46,270,017
JBrowse link
G SLC39A6 solute carrier family 39 member 6 increases expression EXP geldanamycin results in increased expression of SLC39A6 mRNA CTD PMID:26705709 NCBI chr18:36,108,531...36,129,868
Ensembl chr18:36,108,531...36,129,385
JBrowse link
G SLC8A1 solute carrier family 8 member A1 increases expression EXP geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 NCBI chr 2:40,094,523...40,512,452
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SLFN5 schlafen family member 5 increases expression EXP geldanamycin results in increased expression of SLFN5 mRNA CTD PMID:26705709 NCBI chr17:35,243,072...35,273,655
Ensembl chr17:35,243,071...35,273,655
JBrowse link
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 increases expression EXP geldanamycin results in increased expression of SMARCA2 mRNA CTD PMID:26705709 NCBI chr 9:2,015,347...2,193,624
Ensembl chr 9:1,980,290...2,193,624
JBrowse link
G SMC1A structural maintenance of chromosomes 1A increases expression EXP geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 NCBI chr  X:53,374,149...53,422,728
Ensembl chr  X:53,374,149...53,422,728
JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 increases expression EXP geldanamycin results in increased expression of SMCHD1 mRNA CTD PMID:26705709 NCBI chr18:2,655,726...2,805,017
Ensembl chr18:2,655,738...2,805,017
Ensembl chr18:2,655,738...2,805,017
JBrowse link
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 increases expression EXP geldanamycin results in increased expression of SOS2 mRNA CTD PMID:26705709 NCBI chr14:50,117,130...50,231,578
Ensembl chr14:50,117,130...50,231,578
JBrowse link
G SP4 Sp4 transcription factor increases expression EXP geldanamycin results in increased expression of SP4 mRNA CTD PMID:26705709 NCBI chr 7:21,428,083...21,514,822
Ensembl chr 7:21,428,043...21,514,822
JBrowse link
G SPTBN1 spectrin beta, non-erythrocytic 1 increases expression EXP geldanamycin results in increased expression of SPTBN1 mRNA CTD PMID:26705709 NCBI chr 2:54,456,327...54,671,446
Ensembl chr 2:54,456,317...54,671,446
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP
ISO
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]
CTD PMID:10401681, PMID:17223712 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G SRPRA SRP receptor subunit alpha increases expression EXP geldanamycin results in increased expression of SRPR mRNA CTD PMID:26705709 NCBI chr11:126,255,151...126,268,925
Ensembl chr11:126,262,938...126,269,144
JBrowse link
G SRRM2 serine/arginine repetitive matrix 2 increases expression EXP geldanamycin results in increased expression of SRRM2 mRNA CTD PMID:26705709 NCBI chr16:2,750,903...2,771,412
Ensembl chr16:2,752,626...2,772,538
JBrowse link
G SRRT serrate, RNA effector molecule increases expression EXP geldanamycin results in increased expression of SRRT mRNA CTD PMID:26705709 NCBI chr 7:100,874,971...100,888,664
Ensembl chr 7:100,875,103...100,888,664
JBrowse link
G STRN4 striatin 4 decreases expression EXP geldanamycin results in decreased expression of STRN4 mRNA CTD PMID:30166341 NCBI chr19:46,719,509...46,746,475
Ensembl chr19:46,719,511...46,746,994
JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 multiple interactions EXP geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] CTD PMID:16037132, PMID:25645596 NCBI chr16:680,410...682,801
Ensembl chr16:680,224...682,870
JBrowse link
G SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit increases expression EXP geldanamycin results in increased expression of SUPT16H mRNA CTD PMID:26705709 NCBI chr14:21,351,472...21,384,019
Ensembl chr14:21,351,476...21,384,019
JBrowse link
G TEAD1 TEA domain transcription factor 1 increases expression EXP geldanamycin results in increased expression of TEAD1 mRNA CTD PMID:26705709 NCBI chr11:12,674,421...12,944,737
Ensembl chr11:12,674,421...12,944,737
JBrowse link
G TET2 tet methylcytosine dioxygenase 2 increases expression EXP geldanamycin results in increased expression of TET2 mRNA CTD PMID:26705709 NCBI chr 4:105,145,875...105,279,803
Ensembl chr 4:105,145,875...105,279,816
JBrowse link
G TFPI tissue factor pathway inhibitor increases expression EXP geldanamycin results in increased expression of TFPI mRNA CTD PMID:26705709 NCBI chr 2:187,464,230...187,554,501
Ensembl chr 2:187,464,230...187,565,760
JBrowse link
G TGFB2 transforming growth factor beta 2 increases expression EXP geldanamycin results in increased expression of TGFB2 mRNA CTD PMID:26705709 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G THBS1 thrombospondin 1 increases expression EXP geldanamycin results in increased expression of THBS1 mRNA CTD PMID:26705709 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TLE4 TLE family member 4, transcriptional corepressor increases expression EXP geldanamycin results in increased expression of TLE4 mRNA CTD PMID:26705709 NCBI chr 9:79,571,965...79,726,882
Ensembl chr 9:79,571,773...79,726,882
JBrowse link
G TLK1 tousled like kinase 1 increases expression EXP geldanamycin results in increased expression of TLK1 mRNA CTD PMID:26705709 NCBI chr 2:170,990,823...171,231,293
Ensembl chr 2:170,990,823...171,231,314
JBrowse link
G TLL1 tolloid like 1 increases expression EXP geldanamycin results in increased expression of TLL1 mRNA CTD PMID:26705709 NCBI chr 4:165,873,124...166,105,178
Ensembl chr 4:165,873,237...166,104,457
JBrowse link
G TLR4 toll like receptor 4 increases expression EXP geldanamycin results in increased expression of TLR4 mRNA CTD PMID:26705709 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TMEM33 transmembrane protein 33 increases expression EXP geldanamycin results in increased expression of TMEM33 mRNA CTD PMID:26705709 NCBI chr 4:41,935,120...41,960,803
Ensembl chr 4:41,935,129...41,960,803
JBrowse link
G TMOD3 tropomodulin 3 increases expression EXP geldanamycin results in increased expression of TMOD3 mRNA CTD PMID:26705709 NCBI chr15:51,829,653...51,915,725
Ensembl chr15:51,829,628...51,947,295
JBrowse link
G TMTC3 transmembrane O-mannosyltransferase targeting cadherins 3 increases expression EXP geldanamycin results in increased expression of TMTC3 mRNA CTD PMID:26705709 NCBI chr12:88,142,307...88,199,887
Ensembl chr12:88,142,296...88,199,887
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:11472980, PMID:12571865 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10D TNF receptor superfamily member 10d increases expression EXP geldanamycin results in increased expression of TNFRSF10D mRNA CTD PMID:26705709 NCBI chr 8:23,135,588...23,164,027
Ensembl chr 8:23,135,588...23,164,027
JBrowse link
G TNFSF15 TNF superfamily member 15 decreases expression EXP geldanamycin results in decreased expression of TNFSF15 mRNA CTD PMID:26705709 NCBI chr 9:114,784,635...114,806,039
Ensembl chr 9:114,784,652...114,806,039
JBrowse link
G TNKS2 tankyrase 2 increases expression EXP geldanamycin results in increased expression of TNKS2 mRNA CTD PMID:26705709 NCBI chr10:91,798,426...91,865,475
Ensembl chr10:91,798,426...91,865,475
JBrowse link
G TOB2 transducer of ERBB2, 2 increases expression EXP geldanamycin results in increased expression of TOB2 mRNA CTD PMID:26705709 NCBI chr22:41,433,492...41,448,230
Ensembl chr22:41,433,494...41,446,801
JBrowse link
G TP53 tumor protein p53 affects localization
affects expression
multiple interactions
EXP geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]
CTD PMID:17293044, PMID:24211270 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 increases expression EXP geldanamycin results in increased expression of TP53BP1 mRNA CTD PMID:26705709 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
G TPM4 tropomyosin 4 increases expression EXP geldanamycin results in increased expression of TPM4 mRNA CTD PMID:26705709 NCBI chr19:16,067,507...16,103,005
Ensembl chr19:16,067,021...16,103,002
JBrowse link
G TPP2 tripeptidyl peptidase 2 increases expression EXP geldanamycin results in increased expression of TPP2 mRNA CTD PMID:26705709 NCBI chr13:102,596,985...102,679,958
Ensembl chr13:102,596,986...102,679,958
JBrowse link
G TPR translocated promoter region, nuclear basket protein increases expression EXP geldanamycin results in increased expression of TPR mRNA CTD PMID:26705709 NCBI chr 1:186,311,652...186,375,253
Ensembl chr 1:186,311,652...186,375,693
JBrowse link
G TRIM59 tripartite motif containing 59 increases expression EXP geldanamycin results in increased expression of TRIM59 mRNA CTD PMID:26705709 NCBI chr 3:160,435,503...160,449,786
Ensembl chr 3:160,432,445...160,485,773
JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 increases expression EXP geldanamycin results in increased expression of TRPC6 mRNA CTD PMID:26705709 NCBI chr11:101,451,470...101,584,007
Ensembl chr11:101,451,564...101,872,562
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1] CTD PMID:11930156 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TTC3 tetratricopeptide repeat domain 3 increases expression EXP geldanamycin results in increased expression of TTC3 mRNA CTD PMID:26705709 NCBI chr21:37,073,235...37,203,118
Ensembl chr21:37,073,226...37,203,112
JBrowse link
G TTC37 tetratricopeptide repeat domain 37 increases expression EXP geldanamycin results in increased expression of TTC37 mRNA CTD PMID:26705709 NCBI chr 5:95,463,894...95,554,980
Ensembl chr 5:95,461,755...95,555,007
Ensembl chr 5:95,461,755...95,555,007
JBrowse link
G TUBA1A tubulin alpha 1a decreases expression ISO geldanamycin results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,795...49,189,080
JBrowse link
G UBE2H ubiquitin conjugating enzyme E2 H increases expression EXP geldanamycin results in increased expression of UBE2H mRNA CTD PMID:26705709 NCBI chr 7:129,830,732...129,952,960
Ensembl chr 7:129,830,732...129,952,960
JBrowse link
G UBN2 ubinuclein 2 increases expression EXP geldanamycin results in increased expression of UBN2 mRNA CTD PMID:26705709 NCBI chr 7:139,228,408...139,329,421
Ensembl chr 7:139,230,356...139,308,236
JBrowse link
G UGCG UDP-glucose ceramide glucosyltransferase increases expression EXP geldanamycin results in increased expression of UGCG mRNA CTD PMID:26705709 NCBI chr 9:111,896,766...111,935,369
Ensembl chr 9:111,896,814...111,935,369
JBrowse link
G UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 increases expression EXP geldanamycin results in increased expression of UGGT1 mRNA CTD PMID:26705709 NCBI chr 2:128,091,184...128,195,677
Ensembl chr 2:128,091,200...128,195,677
JBrowse link
G UHMK1 U2AF homology motif kinase 1 increases expression EXP geldanamycin results in increased expression of UHMK1 mRNA CTD PMID:26705709 NCBI chr 1:162,497,174...162,529,631
Ensembl chr 1:162,497,251...162,529,631
JBrowse link
G USP10 ubiquitin specific peptidase 10 increases expression EXP geldanamycin results in increased expression of USP10 mRNA CTD PMID:26705709 NCBI chr16:84,699,977...84,779,922
Ensembl chr16:84,699,986...84,779,922
Ensembl chr16:84,699,986...84,779,922
JBrowse link
G USP12 ubiquitin specific peptidase 12 increases expression EXP geldanamycin results in increased expression of USP12 mRNA CTD PMID:26705709 NCBI chr13:27,066,154...27,171,811
Ensembl chr13:27,066,156...27,171,811
JBrowse link
G USP25 ubiquitin specific peptidase 25 increases expression EXP geldanamycin results in increased expression of USP25 mRNA CTD PMID:26705709 NCBI chr21:15,729,947...15,880,064
Ensembl chr21:15,730,025...15,880,069
JBrowse link
G USP36 ubiquitin specific peptidase 36 increases expression EXP geldanamycin results in increased expression of USP36 mRNA CTD PMID:26705709 NCBI chr17:78,787,381...78,841,439
Ensembl chr17:78,787,381...78,841,441
JBrowse link
G VAPB VAMP associated protein B and C increases expression EXP geldanamycin results in increased expression of VAPB mRNA CTD PMID:26705709 NCBI chr20:58,389,211...58,451,101
Ensembl chr20:58,389,229...58,451,101
Ensembl chr20:58,389,229...58,451,101
JBrowse link
G VDAC3 voltage dependent anion channel 3 decreases expression EXP geldanamycin results in decreased expression of VDAC3 mRNA CTD PMID:30166341 NCBI chr 8:42,391,624...42,405,937
Ensembl chr 8:42,391,624...42,405,937
JBrowse link
G VLDLR very low density lipoprotein receptor multiple interactions ISO geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 9:2,621,786...2,660,056
Ensembl chr 9:2,621,787...2,660,056
JBrowse link
G VMP1 vacuole membrane protein 1 increases expression EXP geldanamycin results in increased expression of VMP1 mRNA CTD PMID:26705709 NCBI chr17:59,707,654...59,842,255
Ensembl chr17:59,707,192...59,842,255
JBrowse link
G VPS50 VPS50 subunit of EARP/GARPII complex increases expression EXP geldanamycin results in increased expression of VPS50 mRNA CTD PMID:26705709 NCBI chr 7:93,232,366...93,361,123
Ensembl chr 7:93,232,340...93,361,123
JBrowse link
G ZBED6 zinc finger BED-type containing 6 increases expression EXP geldanamycin results in increased expression of ZBED6 mRNA CTD PMID:26705709 NCBI chr 1:203,797,523...203,801,074
Ensembl chr 1:203,795,714...203,854,999
JBrowse link
G ZC3H11A zinc finger CCCH-type containing 11A increases expression EXP geldanamycin results in increased expression of ZC3H11A mRNA CTD PMID:26705709 NCBI chr 1:203,795,623...203,854,126
Ensembl chr 1:203,795,654...203,854,999
Ensembl chr 1:203,795,654...203,854,999
JBrowse link
G ZFHX4 zinc finger homeobox 4 increases expression EXP geldanamycin results in increased expression of ZFHX4 mRNA CTD PMID:26705709 NCBI chr 8:76,681,219...76,867,285
Ensembl chr 8:76,681,239...76,867,281
JBrowse link
G ZFR zinc finger RNA binding protein increases expression EXP geldanamycin results in increased expression of ZFR mRNA CTD PMID:26705709 NCBI chr 5:32,354,350...32,444,740
Ensembl chr 5:32,354,350...32,444,740
JBrowse link
G ZFX zinc finger protein X-linked increases expression EXP geldanamycin results in increased expression of ZFX mRNA CTD PMID:26705709 NCBI chr  X:24,148,982...24,216,255
Ensembl chr  X:24,149,173...24,216,255
JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 increases expression EXP geldanamycin results in increased expression of ZMYND11 mRNA CTD PMID:26705709 NCBI chr10:130,088...254,637
Ensembl chr10:134,465...254,637
JBrowse link
G ZNF207 zinc finger protein 207 decreases expression EXP geldanamycin results in decreased expression of ZNF207 mRNA CTD PMID:30166341 NCBI chr17:32,350,157...32,381,885
Ensembl chr17:32,350,117...32,381,886
JBrowse link
G ZNF326 zinc finger protein 326 increases expression EXP geldanamycin results in increased expression of ZNF326 mRNA CTD PMID:26705709 NCBI chr 1:89,995,100...90,035,533
Ensembl chr 1:89,995,110...90,035,533
JBrowse link
G ZNF480 zinc finger protein 480 increases expression EXP geldanamycin results in increased expression of ZNF480 mRNA CTD PMID:26705709 NCBI chr19:52,297,169...52,325,927
Ensembl chr19:52,297,169...52,325,922
JBrowse link
G ZNF518A zinc finger protein 518A increases expression EXP geldanamycin results in increased expression of ZNF518A mRNA CTD PMID:26705709 NCBI chr10:96,128,906...96,205,291
Ensembl chr10:96,129,715...96,205,288
JBrowse link
G ZNF638 zinc finger protein 638 increases expression EXP geldanamycin results in increased expression of ZNF638 mRNA CTD PMID:26705709 NCBI chr 2:71,331,782...71,435,061
Ensembl chr 2:71,276,561...71,435,069
JBrowse link
G ZNF655 zinc finger protein 655 increases expression EXP geldanamycin results in increased expression of ZNF655 mRNA CTD PMID:26705709 NCBI chr 7:99,558,544...99,576,453
Ensembl chr 7:99,558,406...99,576,453
JBrowse link
G ZNF660 zinc finger protein 660 increases expression EXP geldanamycin results in increased expression of ZNF660 mRNA CTD PMID:26705709 NCBI chr 3:44,584,964...44,599,694
Ensembl chr 3:44,578,223...44,599,694
JBrowse link
G ZNF669 zinc finger protein 669 increases expression EXP geldanamycin results in increased expression of ZNF669 mRNA CTD PMID:26705709 NCBI chr 1:247,099,962...247,104,356
Ensembl chr 1:247,099,962...247,104,372
JBrowse link
G ZNF704 zinc finger protein 704 increases expression EXP geldanamycin results in increased expression of ZNF704 mRNA CTD PMID:26705709 NCBI chr 8:80,628,451...80,884,416
Ensembl chr 8:80,628,451...80,874,781
JBrowse link
G ZNF711 zinc finger protein 711 increases expression EXP geldanamycin results in increased expression of ZNF711 mRNA CTD PMID:26705709 NCBI chr  X:85,243,820...85,273,362
Ensembl chr  X:85,243,991...85,273,362
Ensembl chr  X:85,243,991...85,273,362
JBrowse link
G ZNF770 zinc finger protein 770 increases expression EXP geldanamycin results in increased expression of ZNF770 mRNA CTD PMID:26705709 NCBI chr15:34,978,341...34,988,287
Ensembl chr15:34,978,341...34,988,287
JBrowse link
G ZXDC ZXD family zinc finger C increases expression EXP geldanamycin results in increased expression of ZXDC mRNA CTD PMID:26705709 NCBI chr 3:126,437,348...126,475,938
Ensembl chr 3:126,437,601...126,475,891
JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
CTD PMID:25968939 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP
ISO
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
CTD PMID:25968939 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions EXP ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G FTL ferritin light chain decreases expression ISO
EXP
ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein
CTD PMID:25968939 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G TFRC transferrin receptor increases expression ISO
EXP
ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FASN fatty acid synthase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
leupeptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP leupeptin inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] CTD PMID:21818627 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AQP8 aquaporin 8 multiple interactions ISO leupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein] CTD PMID:17110522 NCBI chr16:25,216,917...25,228,932
Ensembl chr16:25,215,731...25,228,932
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein] CTD PMID:16242776 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CASP6 caspase 6 multiple interactions EXP leupeptin inhibits the reaction [Estradiol results in increased degradation of and results in decreased activity of CASP6 protein] CTD PMID:15086513 NCBI chr 4:109,688,628...109,703,445
Ensembl chr 4:109,688,622...109,703,583
JBrowse link
G CDC25C cell division cycle 25C increases expression
multiple interactions
EXP leupeptin results in increased expression of CDC25C protein
leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]
CTD PMID:29074359 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDH1 cadherin 1 multiple interactions ISO leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein] CTD PMID:19464575 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CIP2A cellular inhibitor of PP2A multiple interactions EXP leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr 3:108,545,752...108,589,456
Ensembl chr 3:108,549,864...108,589,644
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CTNNB1 protein] CTD PMID:19464575 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSB cathepsin B multiple interactions EXP leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP leupeptin inhibits the reaction [Particulate Matter results in increased secretion of CXCL8 protein] CTD PMID:21818627 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G EGF epidermal growth factor decreases degradation EXP leupeptin results in decreased degradation of EGF protein CTD PMID:23125191 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions EXP leupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL1A protein] CTD PMID:21818627 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL6 interleukin 6 multiple interactions EXP leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] CTD PMID:21818627 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KLK8 kallikrein related peptidase 8 decreases activity EXP leupeptin results in decreased activity of KLK8 protein CTD PMID:16800733 NCBI chr19:50,996,008...51,001,604
Ensembl chr19:50,996,007...51,002,711
JBrowse link
G NEFL neurofilament light multiple interactions EXP leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,957,110
Ensembl chr 8:24,950,955...24,957,110
JBrowse link
G PLIN1 perilipin 1 multiple interactions
decreases degradation
ISO leupeptin inhibits the reaction [Nelfinavir results in increased degradation of PLIN1 protein]
leupeptin results in decreased degradation of PLIN1 protein
CTD PMID:17488708 NCBI chr15:89,664,365...89,679,367
Ensembl chr15:89,664,367...89,679,427
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 increases expression ISO leupeptin results in increased expression of TGFBR1 protein CTD PMID:27826032 NCBI chr 9:99,104,038...99,154,192
Ensembl chr 9:99,104,038...99,154,192
JBrowse link
sciadopitysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
decreases activity
EXP sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
sciadopitysin results in decreased activity of ABCB1 protein
CTD PMID:30790579 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO sciadopitysin results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD PMID:23624148 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:23624148 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
tanespimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD11 abhydrolase domain containing 11 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein CTD PMID:31370342 NCBI chr 7:73,736,094...73,738,866
Ensembl chr 7:73,736,094...73,738,867
JBrowse link
G ACTR1A actin related protein 1A multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein CTD PMID:31370342 NCBI chr10:102,479,229...102,502,712
Ensembl chr10:102,461,881...102,502,712
JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 increases expression EXP tanespimycin results in increased expression of ADAMTS1 mRNA CTD PMID:19514085 NCBI chr21:26,835,755...26,845,409
Ensembl chr21:26,835,755...26,845,409
JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member increases expression
multiple interactions
EXP tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
CTD PMID:31370342 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433
JBrowse link
G AK9 adenylate kinase 9 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein CTD PMID:31370342 NCBI chr 6:109,492,855...109,691,202
Ensembl chr 6:109,492,856...109,691,217
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
EXP
ISO
Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:16923571, PMID:17157164, PMID:18566239, PMID:22810956 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin affects binding
multiple interactions
EXP ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]
CTD PMID:18393300 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein CTD PMID:31370342 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALK ALK receptor tyrosine kinase decreases activity
decreases expression
EXP tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form
CTD PMID:21030459, PMID:21502504 NCBI chr 2:29,190,992...29,921,589
Ensembl chr 2:29,192,774...29,921,586
JBrowse link
G ANXA1 annexin A1 increases expression EXP tanespimycin results in increased expression of ANXA1 protein CTD PMID:31370342 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
EXP Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G AR androgen receptor decreases expression EXP tanespimycin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein CTD PMID:31370342 NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334
JBrowse link
G ATP5F1B ATP synthase F1 subunit beta decreases expression EXP tanespimycin analog results in decreased expression of ATP5F1B protein CTD PMID:31370342 NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP tanespimycin results in decreased expression of BCL2 protein CTD PMID:16923571, PMID:28673683 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP tanespimycin results in decreased expression of BCL2L1 protein CTD PMID:16923571 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 increases expression EXP tanespimycin results in increased expression of BCL2L11 protein CTD PMID:24784839 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase decreases expression
increases expression
ISO
EXP
tanespimycin results in decreased expression of BRAF protein
tanespimycin analog results in increased expression of BRAF protein
CTD PMID:22810956, PMID:31370342 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
Ensembl chr 7:140,719,327...140,924,929
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
increases activity
EXP
ISO
[tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
tanespimycin results in increased cleavage of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15993848, PMID:17157164, PMID:18194434, PMID:19913524, PMID:22810956, PMID:24189122 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases cleavage
multiple interactions
EXP tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein
CTD PMID:17121904 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions
increases cleavage
EXP [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein
CTD PMID:17121904 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions
EXP tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein
CTD PMID:17121904, PMID:17157164 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCT8 chaperonin containing TCP1 subunit 8 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein CTD PMID:31370342 NCBI chr21:29,056,326...29,073,648
Ensembl chr21:29,055,805...29,073,797
JBrowse link
G CDC25C cell division cycle 25C multiple interactions
decreases expression
EXP
ISO
[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein
CTD PMID:21156818, PMID:22810956 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions
decreases expression
EXP [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
tanespimycin results in decreased expression of CDK1 protein
CTD PMID:21156818, PMID:24784839 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164, PMID:28673683 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK8 cyclin dependent kinase 8 decreases expression EXP tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 NCBI chr13:26,254,125...26,405,238
Ensembl chr13:26,254,104...26,405,238
JBrowse link
G CES1 carboxylesterase 1 increases expression EXP tanespimycin analog results in increased expression of CES1 protein CTD PMID:31370342 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CHP2 calcineurin like EF-hand protein 2 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein CTD PMID:31370342 NCBI chr16:23,755,026...23,758,935
Ensembl chr16:23,755,026...23,758,935
JBrowse link
G COMMD1 copper metabolism domain containing 1 multiple interactions EXP tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr 2:61,888,391...62,141,186
Ensembl chr 2:61,888,724...62,147,247
JBrowse link
G CSDE1 cold shock domain containing E1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein CTD PMID:31370342 NCBI chr 1:114,716,916...114,757,984
Ensembl chr 1:114,716,913...114,758,676
JBrowse link
G CTTN cortactin increases expression
multiple interactions
EXP tanespimycin analog results in increased expression of CTTN protein
[tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
CTD PMID:31370342 NCBI chr11:70,398,529...70,436,579
Ensembl chr11:70,398,404...70,436,584
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 affects metabolic processing EXP CYP3A5 protein affects the metabolism of tanespimycin CTD PMID:15718306 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G DARS1 aspartyl-tRNA synthetase 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein CTD PMID:31370342 NCBI chr 2:135,905,881...135,985,684
Ensembl chr 2:135,905,881...135,986,100
JBrowse link
G DHRS2 dehydrogenase/reductase 2 increases expression EXP tanespimycin results in increased expression of DHRS2 protein CTD PMID:31370342 NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639
JBrowse link
G EBF2 EBF transcription factor 2 increases expression EXP tanespimycin analog results in increased expression of EBF2 protein CTD PMID:31370342 NCBI chr 8:25,841,725...26,045,413
Ensembl chr 8:25,841,725...26,045,413
JBrowse link
G ECHDC3 enoyl-CoA hydratase domain containing 3 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein CTD PMID:31370342 NCBI chr10:11,742,382...11,764,070
Ensembl chr10:11,742,366...11,764,070
JBrowse link
G EEF1G eukaryotic translation elongation factor 1 gamma decreases expression
multiple interactions
EXP tanespimycin analog results in decreased expression of EEF1G protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
CTD PMID:31370342 NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
EXP tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein
CTD PMID:31370342 NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463
JBrowse link
G EGFR epidermal growth factor receptor decreases expression
multiple interactions
EXP tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein
CTD PMID:16061882, PMID:17010675, PMID:22810956, PMID:31370342 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF3I eukaryotic translation initiation factor 3 subunit I multiple interactions
decreases expression
EXP [tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein
tanespimycin results in decreased expression of EIF3I protein
CTD PMID:31370342 NCBI chr 1:32,221,584...32,231,604
Ensembl chr 1:32,221,928...32,231,604
JBrowse link
G EIF4B eukaryotic translation initiation factor 4B multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein CTD PMID:31370342 NCBI chr12:53,006,456...53,042,215
Ensembl chr12:53,006,282...53,042,215
Ensembl chr12:53,006,282...53,042,215
JBrowse link
G EIF4H eukaryotic translation initiation factor 4H multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein CTD PMID:31370342 NCBI chr 7:74,174,356...74,197,096
Ensembl chr 7:74,174,245...74,197,101
JBrowse link
G EML5 EMAP like 5 multiple interactions
increases expression
EXP [tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein
CTD PMID:31370342 NCBI chr14:88,612,148...88,792,953
Ensembl chr14:88,612,431...88,792,752
JBrowse link
G ENO1 enolase 1 increases expression EXP tanespimycin analog results in increased expression of ENO1 protein CTD PMID:31370342 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
EXP tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein
CTD PMID:16061882, PMID:24784839 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERI1 exoribonuclease 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein CTD PMID:31370342 NCBI chr 8:8,892,225...9,100,262
Ensembl chr 8:9,002,147...9,116,746
JBrowse link
G ERP29 endoplasmic reticulum protein 29 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein CTD PMID:31370342 NCBI chr12:112,013,340...112,023,449
Ensembl chr12:112,013,348...112,023,449
JBrowse link
G FARSB phenylalanyl-tRNA synthetase subunit beta increases expression
multiple interactions
EXP tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein
[tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein
CTD PMID:31370342 NCBI chr 2:222,566,899...222,656,092
Ensembl chr 2:222,566,899...222,656,092
JBrowse link
G FGF1 fibroblast growth factor 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein CTD PMID:31370342 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G FGFR3 fibroblast growth factor receptor 3 multiple interactions EXP tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein CTD PMID:16061882 NCBI chr 4:1,793,293...1,808,872
Ensembl chr 4:1,793,293...1,808,872
JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 decreases expression EXP tanespimycin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr13:28,003,274...28,100,587
Ensembl chr13:28,003,274...28,100,592
JBrowse link
G FUBP1 far upstream element binding protein 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein CTD PMID:31370342 NCBI chr 1:77,944,055...77,979,435
Ensembl chr 1:77,944,055...77,979,110
JBrowse link
G GCFC2 GC-rich sequence DNA-binding factor 2 increases expression EXP tanespimycin analog results in increased expression of GCFC2 protein CTD PMID:31370342 NCBI chr 2:75,655,606...75,711,642
Ensembl chr 2:75,652,000...75,710,985
JBrowse link
G GLS glutaminase multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein CTD PMID:31370342 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases expression EXP tanespimycin results in decreased expression of GSK3B protein modified form CTD PMID:20090934 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GTF2A2 general transcription factor IIA subunit 2 increases expression EXP tanespimycin analog results in increased expression of GTF2A2 protein CTD PMID:31370342 NCBI chr15:59,638,062...59,657,515
Ensembl chr15:59,638,062...59,657,541
JBrowse link
G GTF2IRD1 GTF2I repeat domain containing 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein CTD PMID:31370342 NCBI chr 7:74,453,906...74,603,070
Ensembl chr 7:74,453,790...74,602,604
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein] CTD PMID:19802386 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HINT1 histidine triad nucleotide binding protein 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein CTD PMID:31370342 NCBI chr 5:131,159,027...131,165,256
Ensembl chr 5:131,155,383...131,224,468
Ensembl chr 5:131,155,383...131,224,468
JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 multiple interactions
decreases expression
EXP [tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein
tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
CTD PMID:31370342 NCBI chr  X:53,431,258...53,434,376
Ensembl chr  X:53,431,258...53,434,370
Ensembl chr  X:53,431,258...53,434,370
JBrowse link
G HSF1 heat shock transcription factor 1 affects localization
multiple interactions
EXP tanespimycin affects the localization of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
CTD PMID:20090934 NCBI chr 8:144,291,603...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions
affects binding
decreases expression
EXP [tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein
CTD PMID:18830594, PMID:22895790, PMID:31370342 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 affects binding EXP tanespimycin binds to HSP90AB1 protein CTD PMID:22895790 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
EXP [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein
CTD PMID:20090934, PMID:31370342 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein CTD PMID:31370342 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
EXP tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP tanespimycin results in increased expression of HSPA5 protein CTD PMID:16357177 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of HSPA6 protein CTD PMID:31370342 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions
ISO
EXP
tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein
CTD PMID:23144451, PMID:31370342 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression
affects expression
ISO
EXP
tanespimycin results in decreased expression of IGF1R protein
tanespimycin affects the expression of IGF1R protein
CTD PMID:22810956 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G ILF3 interleukin enhancer binding factor 3 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein CTD PMID:31370342 NCBI chr19:10,654,295...10,692,400
Ensembl chr19:10,654,261...10,692,417
JBrowse link
G KCNV2 potassium voltage-gated channel modifier subfamily V member 2 decreases expression
multiple interactions
EXP tanespimycin analog results in decreased expression of KCNV2 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein
CTD PMID:31370342 NCBI chr 9:2,717,510...2,730,037
Ensembl chr 9:2,717,510...2,730,037
JBrowse link
G KDM3A lysine demethylase 3A multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein CTD PMID:31370342 NCBI chr 2:86,440,647...86,492,716
Ensembl chr 2:86,440,647...86,492,716
JBrowse link
G KDR kinase insert domain receptor decreases expression
affects expression
ISO
EXP
tanespimycin results in decreased expression of KDR protein
tanespimycin affects the expression of KDR protein
CTD PMID:22810956 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase decreases expression
multiple interactions
EXP
ISO
tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein
CTD PMID:16061882, PMID:16213582, PMID:22810956 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G LARP7 La ribonucleoprotein 7, transcriptional regulator increases expression EXP tanespimycin analog results in increased expression of LARP7 protein CTD PMID:31370342 NCBI chr 4:112,637,143...112,657,586
Ensembl chr 4:112,637,107...112,657,592
JBrowse link
G LCP1 lymphocyte cytosolic protein 1 increases expression
multiple interactions
EXP tanespimycin analog results in increased expression of LCP1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein
CTD PMID:31370342 NCBI chr13:46,125,923...46,182,177
Ensembl chr13:46,125,920...46,211,871
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein CTD PMID:31370342 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G LDHB lactate dehydrogenase B increases expression EXP tanespimycin analog results in increased expression of LDHB protein CTD PMID:31370342 NCBI chr12:21,635,342...21,657,971
Ensembl chr12:21,635,342...21,757,857
JBrowse link
G LMNA lamin A/C multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein CTD PMID:31370342 NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,573...156,140,089
JBrowse link
G LRPPRC leucine rich pentatricopeptide repeat containing multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein CTD PMID:31370342 NCBI chr 2:43,886,224...43,995,989
Ensembl chr 2:43,886,224...43,995,989
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 multiple interactions EXP [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
multiple interactions
EXP
ISO
tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
EXP
ISO
tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein
CTD PMID:17157164, PMID:20090934, PMID:21502504, PMID:22810956, PMID:24784839 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP tanespimycin results in decreased expression of MCL1 protein CTD PMID:16923571 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G MDM2 MDM2 proto-oncogene increases degradation EXP tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase decreases expression EXP
ISO
tanespimycin results in decreased expression of MET protein CTD PMID:22810956 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
JBrowse link
G MIF macrophage migration inhibitory factor multiple interactions
decreases expression
EXP [tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein
CTD PMID:31370342 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MLLT10 MLLT10 histone lysine methyltransferase DOT1L cofactor multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein CTD PMID:31370342 NCBI chr10:21,524,616...21,743,630
Ensembl chr10:21,524,646...21,743,630
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA] CTD PMID:21401309 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA] CTD PMID:21401309 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MSN moesin increases expression EXP tanespimycin analog results in increased expression of MSN protein CTD PMID:31370342 NCBI chr  X:65,588,382...65,741,931
Ensembl chr  X:65,588,377...65,741,931
JBrowse link
G MTAP methylthioadenosine phosphorylase multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein CTD PMID:31370342 NCBI chr 9:21,802,636...21,867,081
Ensembl chr 9:21,802,636...21,937,651
JBrowse link
G MTSS1 MTSS I-BAR domain containing 1 increases expression EXP tanespimycin results in increased expression of MTSS1 mRNA CTD PMID:19514085 NCBI chr 8:124,550,784...124,728,473
Ensembl chr 8:124,550,784...124,728,473
Ensembl chr 8:124,550,784...124,728,473
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein CTD PMID:31370342 NCBI chr 7:106,248,298...106,284,983
Ensembl chr 7:106,248,298...106,286,326
JBrowse link
G NANS N-acetylneuraminate synthase multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein CTD PMID:31370342 NCBI chr 9:98,056,728...98,083,083
Ensembl chr 9:98,056,732...98,083,077
JBrowse link
G NCL nucleolin multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein CTD PMID:31370342 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641
JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression
decreases phosphorylation
ISO
EXP
tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein
CTD PMID:11835313, PMID:22810956 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
increases reduction
increases abundance
EXP [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased susceptibility to tanespimycin
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite
CTD PMID:10564678, PMID:21156818, PMID:24552538 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OAT ornithine aminotransferase multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein CTD PMID:31370342 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G PA2G4 proliferation-associated 2G4 multiple interactions
increases expression
EXP [tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein
tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein
CTD PMID:31370342 NCBI chr12:56,104,559...56,113,910
Ensembl chr12:56,104,537...56,113,910
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP
ISO
tanespimycin results in increased cleavage of PARP1 protein CTD PMID:22810956 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PARP2 poly(ADP-ribose) polymerase 2 increases expression EXP tanespimycin analog results in increased expression of PARP2 protein CTD PMID:31370342 NCBI chr14:20,343,041...20,357,904
Ensembl chr14:20,343,582...20,357,905
JBrowse link
G PDGFRB platelet derived growth factor receptor beta decreases expression ISO
EXP
tanespimycin results in decreased expression of PDGFRB protein CTD PMID:22810956 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein CTD PMID:31370342 NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662
JBrowse link
G PFN1 profilin 1 increases expression EXP tanespimycin analog results in increased expression of PFN1 protein CTD PMID:31370342 NCBI chr17:4,945,652...4,948,530
Ensembl chr17:4,945,652...4,949,061
JBrowse link
G PGR progesterone receptor decreases expression ISO tanespimycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein CTD PMID:31370342 NCBI chr12:57,591,188...57,603,418
Ensembl chr12:57,591,174...57,603,418
JBrowse link
G PKM pyruvate kinase M1/2 decreases expression EXP tanespimycin results in decreased expression of PKM protein CTD PMID:31370342 NCBI chr15:72,199,029...72,231,389
Ensembl chr15:72,199,029...72,231,822
JBrowse link
G PNN pinin, desmosome associated protein increases expression EXP tanespimycin results in increased expression of PNN mRNA CTD PMID:19514085 NCBI chr14:39,175,254...39,183,220
Ensembl chr14:39,175,183...39,183,220
JBrowse link
G PRKRIP1 PRKR interacting protein 1 increases expression EXP tanespimycin analog results in increased expression of PRKRIP1 protein CTD PMID:31370342 NCBI chr 7:102,396,363...102,426,666
Ensembl chr 7:102,363,872...102,426,676
JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein CTD PMID:31370342 NCBI chr  X:12,791,412...12,824,222
Ensembl chr  X:12,791,355...12,824,222
JBrowse link
G PSMA6 proteasome 20S subunit alpha 6 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein CTD PMID:31370342 NCBI chr14:35,278,558...35,317,493
Ensembl chr14:35,278,633...35,317,493
JBrowse link
G PSMA7 proteasome 20S subunit alpha 7 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein CTD PMID:31370342 NCBI chr20:62,136,733...62,143,394
Ensembl chr20:62,136,733...62,143,440
JBrowse link
G RAB17 RAB17, member RAS oncogene family multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein CTD PMID:31370342 NCBI chr 2:237,574,322...237,591,121
Ensembl chr 2:237,574,322...237,601,614
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression EXP tanespimycin results in decreased expression of RAF1 protein CTD PMID:10564678 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,226
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
EXP tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein
CTD PMID:17121904 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RDX radixin multiple interactions
increases expression
EXP [tanespimycin co-treated with VER 155008] results in increased expression of RDX protein
tanespimycin analog results in increased expression of RDX protein
CTD PMID:31370342 NCBI chr11:110,174,922...110,296,614
Ensembl chr11:109,864,295...110,296,712
JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein CTD PMID:31370342 NCBI chr12:120,196,699...120,201,111
Ensembl chr12:120,196,699...120,201,235
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation
decreases expression
EXP tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein
CTD PMID:17121904, PMID:27255535 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G SELENBP1 selenium binding protein 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein CTD PMID:31370342 NCBI chr 1:151,364,304...151,372,725
Ensembl chr 1:151,364,304...151,372,707
JBrowse link
G SERPINB5 serpin family B member 5 increases expression EXP tanespimycin results in increased expression of SERPINB5 mRNA CTD PMID:19514085 NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 decreases expression EXP tanespimycin analog results in decreased expression of SHMT2 protein CTD PMID:31370342 NCBI chr12:57,229,685...57,234,935
Ensembl chr12:57,229,573...57,234,935
JBrowse link
G SOD2 superoxide dismutase 2 increases abundance
increases response to substance
EXP SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin
CTD PMID:21156818 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SRCIN1 SRC kinase signaling inhibitor 1 multiple interactions
increases expression
EXP [tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein
tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
CTD PMID:31370342 NCBI chr17:38,530,015...38,607,166
Ensembl chr17:38,530,031...38,605,952
JBrowse link
G TAGLN2 transgelin 2 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein CTD PMID:31370342 NCBI chr 1:159,918,111...159,925,507
Ensembl chr 1:159,918,107...159,925,732
Ensembl chr 1:159,918,107...159,925,732
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 increases expression EXP tanespimycin results in increased expression of TIMP3 mRNA CTD PMID:19514085 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions EXP [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein CTD PMID:15993848 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TP53 tumor protein p53 decreases expression EXP tanespimycin results in decreased expression of TP53 protein CTD PMID:10564678 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 increases expression EXP tanespimycin analog results in increased expression of TPTE2 protein CTD PMID:31370342 NCBI chr13:19,422,877...19,561,574
Ensembl chr13:19,422,877...19,536,762
JBrowse link
G TYMP thymidine phosphorylase multiple interactions
decreases expression
EXP [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]
tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
CTD PMID:30796972 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G TYMS thymidylate synthetase decreases expression EXP tanespimycin results in decreased expression of TYMS protein CTD PMID:18830594 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression EXP tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein CTD PMID:31370342 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP tanespimycin results in decreased expression of UGP2 protein CTD PMID:31370342 NCBI chr 2:63,840,969...63,891,562
Ensembl chr 2:63,840,940...63,891,562
JBrowse link
G VIL1 villin 1 increases expression EXP tanespimycin analog results in increased expression of VIL1 protein CTD PMID:31370342 NCBI chr 2:218,419,123...218,453,295
Ensembl chr 2:218,419,121...218,453,295
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP [tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:15993848 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
Ensembl chr  X:123,859,724...123,913,976
JBrowse link
G YARS1 tyrosyl-tRNA synthetase 1 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein CTD PMID:31370342 NCBI chr 1:32,775,238...32,818,032
Ensembl chr 1:32,775,237...32,818,153
JBrowse link
G ZNF525 zinc finger protein 525 multiple interactions EXP [tanespimycin co-treated with VER 155008] results in increased expression of ZNF525 protein CTD PMID:31370342 NCBI chr19:53,365,705...53,386,590
Ensembl chr19:53,365,693...53,392,217
JBrowse link
G ZNF630 zinc finger protein 630 increases expression
multiple interactions
EXP tanespimycin analog results in increased expression of ZNF630 protein; tanespimycin results in increased expression of ZNF630 protein
[tanespimycin co-treated with VER 155008] results in increased expression of ZNF630 protein
CTD PMID:31370342 NCBI chr  X:48,057,516...48,071,640
Ensembl chr  X:47,983,356...48,071,658
JBrowse link
G ZYG11B zyg-11 family member B, cell cycle regulator multiple interactions
increases expression
EXP [tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein
tanespimycin analog results in increased expression of ZYG11B protein
CTD PMID:31370342 NCBI chr 1:52,726,453...52,827,336
Ensembl chr 1:52,726,453...52,827,336
JBrowse link
Z-Val-Phe-H term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:16891617 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G CAPN1 calpain 1 multiple interactions
decreases activity
EXP
ISO
calpain inhibitor III inhibits the reaction [CAPN1 protein results in increased susceptibility to Cisplatin]
calpain inhibitor III inhibits the reaction [Calcium results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]
calpain inhibitor III results in decreased activity of CAPN1 protein
CTD PMID:13678654, PMID:20878076, PMID:21985864, PMID:29289695 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN2 calpain 2 multiple interactions ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:16891617 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein] CTD PMID:19336499 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IL1A interleukin 1 alpha affects localization EXP calpain inhibitor III affects the localization of IL1A protein CTD PMID:24024155 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G NEFL neurofilament light multiple interactions ISO calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein] CTD PMID:15275793 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,957,110
Ensembl chr 8:24,950,955...24,957,110
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA] CTD PMID:15316131 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]
calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]
CTD PMID:21683092, PMID:21985864 NCBI chr 9:128,552,564...128,633,662
Ensembl chr 9:128,552,558...128,633,662
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA] CTD PMID:15316131 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24191
    role 24084
      biological role 24050
        biochemical role 23331
          enzyme inhibitor 21377
            EC 3.* (hydrolase) inhibitor 20595
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3301
                EC 3.4.22.* (cysteine endopeptidase) inhibitor 571
                  EC 3.4.22.2 (papain) inhibitor + 0
                  EC 3.4.22.36 (caspase-1) inhibitor + 0
                  EC 3.4.22.38 (cathepsin K) inhibitor + 0
                  EC 3.4.22.56 (caspase-3) inhibitor + 0
                  EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor + 5
                  calpain inhibitor + 28
                  cathepsin L (EC 3.4.22.15) inhibitor + 0
                  cysteine protease inhibitor + 567
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.