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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.4.11.* (aminopeptidase) inhibitor
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Accession:CHEBI:76787 term browser browse the term
Definition:An EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes wtih the action of any aminopeptidase (EC 3.4.11.*).
Synonyms:related_synonym: EC 3.4.11.* inhibitor;   EC 3.4.11.* inhibitors;   aminopeptidase (EC 3.4.11.*) inhibitors


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fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions		 ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein		 CTD PMID:14534293 NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434 		JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity		 EXP
ISO		 fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein		 CTD PMID:14534293 PMID:15516829 PMID:15682466 NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827 		JBrowse link
O-(chloroacetylcarbamoyl)fumagillol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CCND1 protein CTD PMID:15276080 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CDKN1A protein CTD PMID:15276080 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases expression		 ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of FGF2 protein
O-(chloroacetylcarbamoyl)fumagillol results in decreased expression of FGF2 protein		 CTD PMID:12576464 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of MMP9 protein CTD PMID:12576464 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein] CTD PMID:16061884 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO O-(chloroacetylcarbamoyl)fumagillol results in decreased phosphorylation of RB1 protein CTD PMID:15276080 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:17761372 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of TP53 protein CTD PMID:15276080 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
puromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
increases expression
affects response to substance		 ISO
EXP		 ABCB1 protein results in increased transport of Puromycin
Puromycin results in increased expression of ABCB1A mRNA; Puromycin results in increased expression of ABCB1A protein
ABCB1A protein affects the susceptibility to Puromycin		 CTD PMID:14675146 PMID:20018165 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Puromycin results in increased expression of ABCC1 mRNA CTD PMID:20018165 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]; Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]		 CTD PMID:10777561 PMID:25797602 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions EXP Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA] CTD PMID:1953764 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Puromycin affects the localization of BAX protein CTD PMID:18339127 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Puromycin results in decreased expression of BCL2 protein
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]		 CTD PMID:21244482 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein] CTD PMID:21244482 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein] CTD PMID:14502240 PMID:21244482 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Puromycin results in increased activity of CASP9 protein CTD PMID:14502240 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Puromycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Puromycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cd2ap CD2-associated protein decreases expression ISO Puromycin results in decreased expression of CD2AP mRNA CTD PMID:15673299 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdh3 cadherin 3 decreases expression ISO Puromycin results in decreased expression of CDH3 mRNA CTD PMID:15673299 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Puromycin affects the localization of CTNNB1 protein CTD PMID:15673299 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [Puromycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Puromycin results in increased expression of CYP1A1 mRNA		 CTD PMID:2985607 PMID:15385644 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Def6 DEF6 guanine nucleotide exchange factor affects localization ISO Puromycin affects the localization of DEF6 protein CTD PMID:22829599 NCBI chr20:6,268,579...6,290,030
Ensembl chr20:6,268,601...6,289,961 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Puromycin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Puromycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Puromycin inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein] CTD PMID:20525893 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases expression		 ISO Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]
Puromycin results in decreased expression of LDLR mRNA; Puromycin results in decreased expression of LDLR protein		 CTD PMID:12524230 PMID:22388943 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir122 microRNA 122 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR122 mRNA CTD PMID:30682439 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir143 microRNA 143 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR143 mRNA CTD PMID:30682439 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir155 microRNA 155 affects expression EXP Puromycin affects the expression of MIR155 CTD PMID:30169741 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir3473 microRNA 3473 multiple interactions EXP Puromycin results in increased expression of and results in increased secretion of MIR3473 mRNA CTD PMID:30682439 NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Puromycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Optn optineurin multiple interactions ISO OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein] CTD PMID:25096716 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein CTD PMID:19643929 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
increases secretion		 ISO Puromycin results in decreased expression of VEGFA protein
OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein]		 CTD PMID:20116850 PMID:25096716 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        biochemical role 19567
          enzyme inhibitor 18735
            EC 3.* (hydrolase) inhibitor 18346
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4417
                EC 3.4.11.* (aminopeptidase) inhibitor 45
                  EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor + 31
                  EC 3.4.11.18 (methionyl aminopeptidase) inhibitor + 15
                  amastatin 0
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