|
G |
ENPEP |
glutamyl aminopeptidase |
multiple interactions increases hydrolysis |
EXP |
1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] |
CTD |
PMID:8141778 |
|
NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
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|
|
G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions affects localization |
EXP |
Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein] |
CTD |
PMID:19523970 |
|
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
|
|
G |
CASP6 |
caspase 6 |
multiple interactions increases expression |
EXP |
Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA] |
CTD |
PMID:19523970 |
|
NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
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|
G |
CYCS |
cytochrome c, somatic |
multiple interactions affects localization |
EXP |
Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein] |
CTD |
PMID:23347876 |
|
NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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|
G |
DNM1L |
dynamin 1 like |
multiple interactions increases expression |
EXP |
Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein] |
CTD |
PMID:23347876 |
|
NCBI chr 5:41,571,054...41,636,058
|
|
G |
EDN1 |
endothelin 1 |
increases secretion |
EXP |
Cyclosporine results in increased secretion of EDN1 protein |
CTD |
PMID:16391421 |
|
NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
|
|
G |
MFN2 |
mitofusin 2 |
multiple interactions decreases expression |
EXP |
Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein] |
CTD |
PMID:23347876 |
|
NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,026,722...72,056,439
|
|
G |
NOS3 |
nitric oxide synthase 3 |
decreases expression |
EXP |
Cyclosporine results in decreased expression of NOS3 protein |
CTD |
PMID:12695417 |
|
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
|
|
G |
OPA1 |
OPA1 mitochondrial dynamin like GTPase |
decreases expression multiple interactions |
EXP |
Cyclosporine results in decreased expression of OPA1 protein Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein] |
CTD |
PMID:23347876 |
|
NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,823...130,719,083
|
|
G |
RAC1 |
Rac family small GTPase 1 |
affects localization |
EXP |
Cyclosporine affects the localization of RAC1 protein |
CTD |
PMID:12695417 |
|
NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,771...4,803,687
|
|
G |
SLC2A1 |
solute carrier family 2 member 1 |
decreases response to substance multiple interactions increases expression |
EXP |
SLC2A1 protein results in decreased susceptibility to Cyclosporine Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein] Cyclosporine results in increased expression of SLC2A1 mRNA; Cyclosporine results in increased expression of SLC2A1 protein |
CTD |
PMID:12081571 |
|
NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,534,655...168,690,095
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|
|
G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
EXP |
ochratoxin A results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:30287338 |
|
|
|
G |
ANXA5 |
annexin A5 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of ANXA5 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
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|
G |
ATG5 |
autophagy related 5 |
multiple interactions increases expression |
EXP |
ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein] ochratoxin A results in increased expression of ATG5 protein |
CTD |
PMID:28699257 PMID:30287338 |
|
NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,453
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|
G |
BCL2 |
BCL2 apoptosis regulator |
decreases expression affects expression multiple interactions |
EXP |
ochratoxin A results in decreased expression of BCL2 mRNA ochratoxin A affects the expression of BCL2 mRNA TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA] |
CTD |
PMID:28528741 PMID:29080797 |
|
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
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|
G |
BECN1 |
beclin 1 |
multiple interactions increases expression |
EXP |
BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein] ochratoxin A results in increased expression of BECN1 protein |
CTD |
PMID:30287338 |
|
NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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|
G |
BRCA1 |
BRCA1 DNA repair associated |
increases expression |
EXP |
ochratoxin A results in increased expression of BRCA1 protein |
CTD |
PMID:32454083 |
|
NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570
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|
G |
CASP3 |
caspase 3 |
multiple interactions increases cleavage |
EXP |
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] |
CTD |
PMID:30287338 |
|
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
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G |
CAT |
catalase |
decreases expression |
EXP |
ochratoxin A results in decreased expression of CAT protein |
CTD |
PMID:18547704 |
|
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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|
G |
CRYAB |
crystallin alpha B |
increases expression |
EXP |
ochratoxin A results in increased expression of CRYAB mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530
|
|
G |
CYP2G2 |
cytochrome P450 family 2 subfamily G member 2 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of CYP2A6 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 6:49,069,613...49,084,953
|
|
G |
DAD1 |
defender against cell death 1 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of DAD1 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,029...76,457,192
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|
G |
DNMT1 |
DNA methyltransferase 1 |
increases expression multiple interactions |
EXP |
ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein] |
CTD |
PMID:29080797 PMID:30923867 |
|
NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
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|
G |
DNMT3A |
DNA methyltransferase 3 alpha |
increases expression |
EXP |
ochratoxin A results in increased expression of DNMT3A mRNA |
CTD |
PMID:29080797 PMID:30923867 |
|
NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
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|
G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
decreases expression multiple interactions |
EXP |
ochratoxin A results in decreased expression of GCLC mRNA ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA] |
CTD |
PMID:18547363 |
|
NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
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|
G |
GLMN |
glomulin, FKBP associated protein |
increases expression |
EXP |
ochratoxin A results in increased expression of GLMN mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,979...124,813,337
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|
G |
HDAC1 |
histone deacetylase 1 |
multiple interactions increases expression |
EXP |
Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein] ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein |
CTD |
PMID:29080797 |
|
NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
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|
G |
HSP90B1 |
heat shock protein 90 beta family member 1 |
increases expression decreases expression |
EXP |
ochratoxin A results in increased expression of HSP90B1 mRNA ochratoxin A results in decreased expression of HSP90B1 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein |
CTD |
PMID:28699257 |
|
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
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|
G |
HSPD1 |
heat shock protein family D (Hsp60) member 1 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of HSPD1 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
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|
G |
ID2 |
inhibitor of DNA binding 2 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of ID2 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,759...127,503,257
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G |
IGFBP2 |
insulin like growth factor binding protein 2 |
increases expression |
EXP |
ochratoxin A results in increased expression of IGFBP2 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
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|
G |
IL1A |
interleukin 1 alpha |
multiple interactions |
EXP |
ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] |
CTD |
PMID:28528741 |
|
NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
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|
G |
IL2 |
interleukin 2 |
decreases secretion |
EXP |
ochratoxin A results in decreased secretion of IL2 protein |
CTD |
PMID:28699257 |
|
NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
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G |
IL4 |
interleukin 4 |
increases expression |
EXP |
ochratoxin A results in increased expression of IL4 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
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|
G |
IL6 |
interleukin 6 |
increases expression multiple interactions |
EXP |
ochratoxin A results in increased expression of IL6 mRNA NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA] |
CTD |
PMID:28710020 |
|
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
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|
G |
JAK2 |
Janus kinase 2 |
multiple interactions increases phosphorylation |
EXP |
Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:30923867 |
|
NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
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|
G |
LOC100522201 |
histone H2AX |
multiple interactions increases expression |
EXP |
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] |
CTD |
PMID:30923867 |
|
NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
|
|
G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation multiple interactions |
EXP |
ochratoxin A results in increased phosphorylation of MAPK1 protein ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:28528741 PMID:28699257 |
|
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
|
|
G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP |
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] ochratoxin A results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:28528741 PMID:28699257 |
|
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
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|
G |
MTOR |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
EXP |
ochratoxin A results in decreased phosphorylation of MTOR protein |
CTD |
PMID:30287338 |
|
NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
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|
G |
MYD88 |
MYD88 innate immune signal transduction adaptor |
multiple interactions |
EXP |
ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] |
CTD |
PMID:28528741 |
|
NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
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|
G |
NEIL1 |
nei like DNA glycosylase 1 |
decreases expression multiple interactions |
EXP |
ochratoxin A results in decreased expression of NEIL1 mRNA alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA] |
CTD |
PMID:30923867 |
|
NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
|
|
G |
NEIL3 |
nei like DNA glycosylase 3 |
multiple interactions decreases expression |
EXP |
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA] |
CTD |
PMID:30923867 |
|
NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
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|
G |
NFE2L2 |
nuclear factor, erythroid 2 like 2 |
decreases activity multiple interactions decreases expression |
EXP |
ochratoxin A results in decreased activity of NFE2L2 protein NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforafan affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of NFE2L2 mRNA] ochratoxin A results in decreased expression of NFE2L2 mRNA |
CTD |
PMID:18547363 PMID:18547704 PMID:28710020 |
|
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
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G |
NPM1 |
nucleophosmin 1 |
increases expression |
EXP |
ochratoxin A results in increased expression of NPM1 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,296...52,781,740
|
|
G |
OGG1 |
8-oxoguanine DNA glycosylase |
decreases expression multiple interactions |
EXP |
ochratoxin A results in decreased expression of OGG1 mRNA alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA] |
CTD |
PMID:30923867 |
|
NCBI chr13:66,038,669...66,045,478
|
|
G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
increases cleavage increases expression multiple interactions |
EXP |
ochratoxin A results in increased cleavage of PARP1 protein ochratoxin A results in increased expression of PARP1 protein 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] |
CTD |
PMID:30287338 PMID:32454083 |
|
NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
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|
G |
PCK1 |
phosphoenolpyruvate carboxykinase 1 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein |
CTD |
PMID:3753873 |
|
NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
|
|
G |
PCNA |
proliferating cell nuclear antigen |
decreases expression |
EXP |
ochratoxin A results in decreased expression of PCNA protein |
CTD |
PMID:32454083 |
|
NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
|
|
G |
PFDN5 |
prefoldin subunit 5 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of PFDN5 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,719...18,525,877
|
|
G |
PPIA |
peptidylprolyl isomerase A |
increases expression |
EXP |
ochratoxin A results in increased expression of PPIA mRNA |
CTD |
PMID:14994279 |
|
NCBI chr18:50,563,130...50,566,857
|
|
G |
PRDX1 |
peroxiredoxin 1 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of PRDX1 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442
|
|
G |
PTMA |
prothymosin alpha |
decreases expression |
EXP |
ochratoxin A results in decreased expression of PTMA mRNA |
CTD |
PMID:14994279 |
|
NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435
|
|
G |
RAD51 |
RAD51 recombinase |
increases expression |
EXP |
ochratoxin A results in increased expression of RAD51 protein |
CTD |
PMID:32454083 |
|
NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,647...130,640,136
|
|
G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:28528741 |
|
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
|
|
G |
RPA2 |
replication protein A2 |
increases expression |
EXP |
ochratoxin A results in increased expression of RPA2 protein |
CTD |
PMID:32454083 |
|
NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,578...85,045,916
|
|
G |
RPS5 |
ribosomal protein S5 |
increases expression |
EXP |
ochratoxin A results in increased expression of RPS5 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,921,635...62,974,354
|
|
G |
SOCS3 |
suppressor of cytokine signaling 3 |
increases expression multiple interactions |
EXP |
ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein] |
CTD |
PMID:30923867 |
|
NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
|
|
G |
SOD1 |
superoxide dismutase 1 |
decreases activity |
EXP |
ochratoxin A results in decreased activity of SOD1 protein |
CTD |
PMID:18547704 |
|
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
|
|
G |
SQSTM1 |
sequestosome 1 |
multiple interactions decreases expression |
EXP |
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein] |
CTD |
PMID:30287338 |
|
NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
|
|
G |
STAT3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
EXP |
Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] |
CTD |
PMID:30923867 |
|
NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
|
|
G |
SUMO1 |
small ubiquitin like modifier 1 |
decreases expression |
EXP |
ochratoxin A results in decreased expression of SUMO1 mRNA |
CTD |
PMID:14994279 |
|
NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943
|
|
G |
TGFB1 |
transforming growth factor beta 1 |
increases expression multiple interactions |
EXP |
ochratoxin A results in increased expression of TGFB1 mRNA NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforafan inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA] |
CTD |
PMID:28710020 |
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NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
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G |
TIMP2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
EXP |
ochratoxin A results in increased expression of TIMP2 mRNA |
CTD |
PMID:14994279 |
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NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
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G |
TJP1 |
tight junction protein 1 |
affects localization |
EXP |
ochratoxin A affects the localization of TJP1 protein |
CTD |
PMID:14994279 |
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NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
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G |
TLR4 |
toll like receptor 4 |
multiple interactions |
EXP |
ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] |
CTD |
PMID:28528741 |
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NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
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G |
TNF |
tumor necrosis factor |
multiple interactions increases secretion |
EXP |
ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] ochratoxin A results in increased secretion of TNF protein |
CTD |
PMID:28528741 PMID:28699257 |
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NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
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G |
TP53 |
tumor protein p53 |
multiple interactions increases expression |
EXP |
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein] |
CTD |
PMID:28710020 PMID:32454083 |
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NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
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G |
XPA |
XPA, DNA damage recognition and repair factor |
decreases expression |
EXP |
ochratoxin A results in decreased expression of XPA mRNA |
CTD |
PMID:14994279 |
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NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649
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G |
XRCC1 |
X-ray repair cross complementing 1 |
increases expression |
EXP |
ochratoxin A results in increased expression of XRCC1 protein |
CTD |
PMID:32454083 |
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NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710
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G |
NFE2L2 |
nuclear factor, erythroid 2 like 2 |
decreases activity |
EXP |
ochratoxin B results in decreased activity of NFE2L2 protein |
CTD |
PMID:18547704 |
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NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
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G |
LEP |
leptin |
affects expression |
EXP |
Okadaic Acid affects the expression of LEP mRNA |
CTD |
PMID:10628429 |
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NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
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G |
ATP1A1 |
ATPase Na+/K+ transporting subunit alpha 1 |
decreases activity |
EXP |
Ouabain results in decreased activity of ATP1A1 protein |
CTD |
PMID:28438630 |
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NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606
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G |
CASP3 |
caspase 3 |
decreases cleavage |
EXP |
Ouabain results in decreased cleavage of CASP3 protein |
CTD |
PMID:28438630 |
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NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
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G |
DUOX2 |
dual oxidase 2 |
affects folding |
EXP |
oxophenylarsine affects the folding of DUOX2 protein |
CTD |
PMID:10601291 |
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NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,477...126,641,419
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
increases expression |
EXP |
oxophenylarsine results in increased expression of HIF1A protein |
CTD |
PMID:11514583 |
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NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
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G |
INS |
insulin |
multiple interactions |
EXP |
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid] |
CTD |
PMID:1928324 PMID:8048502 |
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NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
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G |
NOS3 |
nitric oxide synthase 3 |
decreases phosphorylation affects localization |
EXP |
oxophenylarsine results in decreased phosphorylation of NOS3 protein oxophenylarsine affects the localization of NOS3 protein |
CTD |
PMID:9546377 |
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NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
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