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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.* (hydrolase) inhibitor
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Accession:CHEBI:76759 term browser browse the term
Definition:Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
Synonyms:related_synonym: EC 3.* (hydrolase) inhibitors;   EC 3.* inhibitor;   EC 3.* inhibitors;   hydrolase inhibitor;   hydrolase inhibitors
 xref: Wikipedia:Hydrolase



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(-)-epigallocatechin 3-gallate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578 PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
epigallocatechin gallate results in decreased expression of CCL2 mRNA
CTD PMID:20580034 PMID:22521609 PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
epigallocatechin gallate results in decreased activity of CYP1A1 protein
epigallocatechin gallate results in decreased expression of CYP1A1 mRNA
CTD PMID:12970578 PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions
increases expression
EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA] CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA]; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP epigallocatechin gallate results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA]
CTD PMID:22521609 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
epigallocatechin gallate results in decreased expression of VCAM1 mRNA
CTD PMID:22521609 PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
(25R)-cholest-5-ene-3beta,26-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,343,123...74,372,621
JBrowse link
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OPRM1 opioid receptor mu 1 multiple interactions EXP Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]; omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]] CTD PMID:12031848 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 increases uptake EXP SLC22A5 protein results in increased uptake of Carnitine CTD PMID:16826461 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219
JBrowse link
(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294
JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301
JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion
EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein
CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123
JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
G CYP19A3 cytochrome P450 19A3 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion
EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein
CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326
JBrowse link
G LAMB1 laminin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of LAMB1 mRNA CTD PMID:32423882 NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 mRNA
CTD PMID:32423882 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA
CTD PMID:32423882 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK8 protein
Nicotine results in decreased expression of MAPK8 mRNA
CTD PMID:32423882 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Nicotine results in increased expression of MMP9 mRNA CTD PMID:32423882 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
JBrowse link
G OCLN occludin decreases expression EXP Nicotine results in decreased expression of OCLN mRNA CTD PMID:32423882 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 decreases expression EXP Nicotine results in decreased expression of RPP38 mRNA CTD PMID:32423882 NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,197...46,725,920
JBrowse link
1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions
decreases activity
EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
JBrowse link
G ENPEP glutamyl aminopeptidase multiple interactions EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
26-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,343,123...74,372,621
JBrowse link
4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF4 protein] CTD PMID:36754226 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF6 protein] CTD PMID:36754226 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein] CTD PMID:36754226 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
JBrowse link
G CASP3 caspase 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CLDN1 claudin 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein] CTD PMID:36754226 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G CLDN3 claudin 3 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN3 protein] CTD PMID:36754226 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of DDIT3 protein] CTD PMID:36754226 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of ERN1 protein] CTD PMID:36754226 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 protein] CTD PMID:36754226 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G OCLN occludin multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of OCLN protein] CTD PMID:36754226 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G TJP1 tight junction protein 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of TJP1 protein] CTD PMID:36754226 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 multiple interactions EXP SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione] CTD PMID:11861319 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
actinomycin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 multiple interactions EXP Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of CAPN1 mRNA] CTD PMID:9728040 NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA] CTD PMID:9463523 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein] CTD PMID:16759985 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSNK1A1 casein kinase 1 alpha 1 decreases activity
affects activity
EXP Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein
CTD PMID:21413800 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284
JBrowse link
alachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to alachlor CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455
JBrowse link
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases uptake
multiple interactions
EXP INS protein results in increased uptake of 2-(methylamino)isobutyric acid
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
alternariol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression EXP alternariol results in decreased expression of CYP11A1 protein CTD PMID:19429235 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
amastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions EXP amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
JBrowse link
G PLG plasminogen multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,192...7,110,555
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions EXP Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867
JBrowse link
amino acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN3 claudin 3 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein] CTD PMID:26338884 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
JBrowse link
G CLDN4 claudin 4 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein] CTD PMID:26338884 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
JBrowse link
G SLC1A1 solute carrier family 1 member 1 increases expression EXP Amino Acids results in increased expression of SLC1A1 mRNA; Amino Acids results in increased expression of SLC1A1 protein CTD PMID:26338884 NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674
JBrowse link
G TJP2 tight junction protein 2 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein] CTD PMID:26338884 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
JBrowse link
G TJP3 tight junction protein 3 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein] CTD PMID:26338884 NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531
JBrowse link
aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917
JBrowse link
ammonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABI3BP ABI family member 3 binding protein decreases expression EXP Ammonia results in decreased expression of ABI3BP mRNA CTD PMID:34389318 NCBI chr13:158,013,704...158,291,093
Ensembl chr13:158,013,726...158,291,103
JBrowse link
G ALB albumin increases expression EXP Ammonia results in increased expression of ALB mRNA CTD PMID:34389318 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
JBrowse link
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A increases expression EXP Ammonia results in increased expression of ANKS1A mRNA CTD PMID:34389318 NCBI chr 7:30,812,925...30,995,369
Ensembl chr 7:30,812,920...30,995,360
JBrowse link
G APOB apolipoprotein B increases expression EXP Ammonia results in increased expression of APOB mRNA CTD PMID:34389318 NCBI chr 3:117,250,096...117,316,200
Ensembl chr 3:117,250,096...117,316,200
JBrowse link
G APOC3 apolipoprotein C3 increases expression EXP Ammonia results in increased expression of APOC3 mRNA CTD PMID:34389318 NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533
JBrowse link
G APOH apolipoprotein H increases expression EXP Ammonia results in increased expression of APOH mRNA CTD PMID:34389318 NCBI chr12:12,827,195...12,839,172
Ensembl chr12:12,827,201...12,839,175
JBrowse link
G ASRGL1 asparaginase and isoaspartyl peptidase 1 increases expression EXP Ammonia results in increased expression of ASRGL1 mRNA CTD PMID:34389318 NCBI chr 2:9,328,260...9,353,384
Ensembl chr 2:9,328,269...9,353,340
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Ammonia results in increased expression of ATF3 mRNA CTD PMID:34389318 NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506
JBrowse link
G AVP vasopressin increases expression EXP Ammonia results in increased expression of AVP mRNA CTD PMID:34389318 NCBI chr17:32,581,234...32,583,145
Ensembl chr17:32,581,234...32,583,185
JBrowse link
G BMP4 bone morphogenetic protein 4 decreases expression EXP Ammonia results in decreased expression of BMP4 mRNA CTD PMID:34389318 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637
JBrowse link
G BPI bactericidal permeability increasing protein increases expression EXP Ammonia results in increased expression of BPI mRNA CTD PMID:34389318 NCBI chr17:41,344,878...41,392,103
Ensembl chr17:41,344,939...41,392,100
JBrowse link
G BTG2 BTG anti-proliferation factor 2 increases expression EXP Ammonia results in increased expression of BTG2 mRNA CTD PMID:34389318 NCBI chr 9:64,033,853...64,037,795
Ensembl chr 9:64,031,832...64,035,837
JBrowse link
G C7 complement C7 decreases expression EXP Ammonia results in decreased expression of C7 mRNA CTD PMID:34389318 NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980
JBrowse link
G CA12 carbonic anhydrase 12 decreases expression EXP Ammonia results in decreased expression of CA12 mRNA CTD PMID:34389318 NCBI chr 1:108,649,277...108,710,658
Ensembl chr 1:108,649,271...108,710,651
JBrowse link
G CALCOCO1 calcium binding and coiled-coil domain 1 decreases expression EXP Ammonia results in decreased expression of CALCOCO1 mRNA CTD PMID:34389318 NCBI chr 5:18,910,698...18,930,402
Ensembl chr 5:18,910,700...18,930,321
JBrowse link
G CARNS1 carnosine synthase 1 increases expression EXP Ammonia results in increased expression of CARNS1 mRNA CTD PMID:34389318 NCBI chr 2:5,097,238...5,105,697
Ensembl chr 2:5,097,243...5,105,696
JBrowse link
G CCDC158 coiled-coil domain containing 158 increases expression EXP Ammonia results in increased expression of CCDC158 mRNA CTD PMID:34389318 NCBI chr 8:71,990,113...72,088,966
Ensembl chr 8:71,990,119...72,088,829
JBrowse link
G CCL16 C-C motif chemokine ligand 16 increases expression EXP Ammonia results in increased expression of CCL16 mRNA CTD PMID:34389318 NCBI chr12:39,618,187...39,621,557
Ensembl chr12:39,618,414...39,621,409
JBrowse link
G CCR2 C-C motif chemokine receptor 2 decreases expression EXP Ammonia results in decreased expression of CCR2 mRNA CTD PMID:34389318 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343
JBrowse link
G CD3E CD3 epsilon subunit of T-cell receptor complex decreases expression EXP Ammonia results in decreased expression of CD3E mRNA CTD PMID:34389318 NCBI chr 9:45,619,730...45,633,972
Ensembl chr 9:45,619,482...45,633,968
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression EXP Ammonia results in decreased expression of CPT1A mRNA CTD PMID:34389318 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression EXP Ammonia results in decreased expression of CXCL10 mRNA CTD PMID:34389318 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 decreases expression EXP Ammonia results in decreased expression of CXCL11 mRNA CTD PMID:34389318 NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674
JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 decreases expression EXP Ammonia results in decreased expression of CXCL14 mRNA CTD PMID:34389318 NCBI chr 2:137,803,988...137,813,118
Ensembl chr 2:137,803,992...137,813,118
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 decreases expression EXP Ammonia results in decreased expression of CXCL9 mRNA CTD PMID:34389318 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression EXP Ammonia results in decreased expression of CYP1A1 mRNA CTD PMID:34389318 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression EXP Ammonia results in decreased expression of CYP1B1 mRNA CTD PMID:34389318 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683
JBrowse link
G CYP2C49 cytochrome P450 2C49 increases expression EXP Ammonia results in increased expression of CYP2C49 mRNA CTD PMID:34389318 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Ammonia results in increased expression of CYP2E1 mRNA CTD PMID:34389318 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
JBrowse link
G CYP3A39 cytochrome P450 3A39 increases expression EXP Ammonia results in increased expression of CYP3A39 mRNA CTD PMID:34389318
G DAB2IP DAB2 interacting protein decreases expression EXP Ammonia results in decreased expression of DAB2IP mRNA CTD PMID:34389318 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,022
JBrowse link
G DCAF8 DDB1 and CUL4 associated factor 8 increases expression EXP Ammonia results in increased expression of DCAF8 mRNA CTD PMID:34389318 NCBI chr 4:90,214,916...90,263,259
Ensembl chr 4:90,214,973...90,261,737
JBrowse link
G DCUN1D1 defective in cullin neddylation 1 domain containing 1 decreases expression EXP Ammonia results in decreased expression of DCUN1D1 mRNA CTD PMID:34389318 NCBI chr13:120,914,001...120,950,825 JBrowse link
G DDX20 DEAD-box helicase 20 decreases expression EXP Ammonia results in decreased expression of DDX20 mRNA CTD PMID:34389318 NCBI chr 4:108,625,121...108,636,382
Ensembl chr 4:108,624,987...108,647,342
JBrowse link
G DMGDH dimethylglycine dehydrogenase decreases expression EXP Ammonia results in decreased expression of DMGDH mRNA CTD PMID:34389318 NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679
JBrowse link
G DOCK2 dedicator of cytokinesis 2 decreases expression EXP Ammonia results in decreased expression of DOCK2 mRNA CTD PMID:34389318 NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638
JBrowse link
G DUOX2 dual oxidase 2 decreases expression EXP Ammonia results in decreased expression of DUOX2 mRNA CTD PMID:34389318 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406
JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression EXP Ammonia results in increased expression of DUSP1 mRNA CTD PMID:34389318 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086
JBrowse link
G EGR1 early growth response 1 increases expression EXP Ammonia results in increased expression of EGR1 mRNA CTD PMID:34389318 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
JBrowse link
G F12 coagulation factor XII decreases expression EXP Ammonia results in decreased expression of F12 mRNA CTD PMID:34389318 NCBI chr 2:80,527,451...80,544,835
Ensembl chr 2:80,527,446...80,544,828
JBrowse link
G FAM177A1 family with sequence similarity 177 member A1 decreases expression EXP Ammonia results in decreased expression of FAM177A1 mRNA CTD PMID:34389318 NCBI chr 7:64,788,829...64,808,640
Ensembl chr 7:64,788,077...64,808,473
JBrowse link
G FAM180B family with sequence similarity 180 member B decreases expression EXP Ammonia results in decreased expression of FAM180B mRNA CTD PMID:34389318 NCBI chr 2:15,027,360...15,029,999
Ensembl chr 2:15,027,362...15,029,982
JBrowse link
G FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) decreases expression EXP Ammonia results in decreased expression of FCGR1A mRNA CTD PMID:34389318 NCBI chr 4:99,233,632...99,242,531
Ensembl chr 4:99,233,611...99,242,586
JBrowse link
G FGA fibrinogen alpha chain increases expression EXP Ammonia results in increased expression of FGA mRNA CTD PMID:34389318 NCBI chr 8:74,574,870...74,584,202
Ensembl chr 8:74,574,882...74,584,202
JBrowse link
G FGB fibrinogen beta chain increases expression EXP Ammonia results in increased expression of FGB mRNA CTD PMID:34389318 NCBI chr 8:74,598,170...74,607,409
Ensembl chr 8:74,595,688...74,607,409
JBrowse link
G FGG fibrinogen gamma chain increases expression EXP Ammonia results in increased expression of FGG mRNA CTD PMID:34389318 NCBI chr 8:74,553,040...74,562,151
Ensembl chr 8:74,553,105...74,563,688
JBrowse link
G FNIP1 folliculin interacting protein 1 increases expression EXP Ammonia results in increased expression of FNIP1 mRNA CTD PMID:34389318 NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,957,553...134,093,413
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Ammonia results in increased expression of FOS mRNA CTD PMID:34389318 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Ammonia results in increased expression of FOSB mRNA CTD PMID:34389318 NCBI chr 6:51,836,780...51,844,531
Ensembl chr 6:51,837,719...51,844,529
JBrowse link
G FOXJ1 forkhead box J1 increases expression EXP Ammonia results in increased expression of FOXJ1 mRNA CTD PMID:34389318 NCBI chr12:5,307,370...5,312,117
Ensembl chr12:5,307,374...5,312,106
JBrowse link
G GORASP1 golgi reassembly stacking protein 1 increases expression EXP Ammonia results in increased expression of GORASP1 mRNA CTD PMID:34389318 NCBI chr13:23,786,245...23,797,508
Ensembl chr13:23,786,248...23,797,487
JBrowse link
G GPR182 G protein-coupled receptor 182 increases expression EXP Ammonia results in increased expression of GPR182 mRNA CTD PMID:34389318 NCBI chr 5:22,303,466...22,309,652
Ensembl chr 5:22,304,588...22,311,028
JBrowse link
G GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) decreases expression EXP Ammonia results in decreased expression of GZMA mRNA CTD PMID:34389318 NCBI chr16:34,282,160...34,290,422
Ensembl chr16:34,282,120...34,290,477
JBrowse link
G HNF4G hepatocyte nuclear factor 4 gamma increases expression EXP Ammonia results in increased expression of HNF4G mRNA CTD PMID:34389318 NCBI chr 4:60,505,388...60,641,052
Ensembl chr 4:60,505,385...60,595,789
JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase decreases expression EXP Ammonia results in decreased expression of HPGD mRNA CTD PMID:34389318 NCBI chr14:15,718,261...15,773,534
Ensembl chr14:15,718,678...15,760,767
JBrowse link
G HPX hemopexin increases expression EXP Ammonia results in increased expression of HPX mRNA CTD PMID:34389318 NCBI chr 9:3,288,288...3,297,051
Ensembl chr 9:3,288,172...3,297,047
JBrowse link
G IL4R interleukin 4 receptor increases expression EXP Ammonia results in increased expression of IL4R mRNA CTD PMID:34389318 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544
JBrowse link
G ITPKB inositol-trisphosphate 3-kinase B decreases expression EXP Ammonia results in decreased expression of ITPKB mRNA CTD PMID:34389318 NCBI chr10:14,362,883...14,469,586 JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 increases expression EXP Ammonia results in increased expression of KCNAB1 mRNA CTD PMID:34389318 NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,378...96,375,856
JBrowse link
G KCNK5 potassium two pore domain channel subfamily K member 5 increases expression EXP Ammonia results in increased expression of KCNK5 mRNA CTD PMID:34389318 NCBI chr 7:34,617,948...34,656,705
Ensembl chr 7:34,617,956...34,656,697
JBrowse link
G KDM5A lysine demethylase 5A increases expression EXP Ammonia results in increased expression of KDM5A mRNA CTD PMID:34389318 NCBI chr 5:67,628,791...67,716,143
Ensembl chr 5:67,629,380...67,715,905
JBrowse link
G KDM5C lysine demethylase 5C decreases expression EXP Ammonia results in decreased expression of KDM5C mRNA CTD PMID:34389318 NCBI chr  X:45,968,812...46,003,215
Ensembl chr  X:45,968,814...46,003,215
JBrowse link
G KIF20A kinesin family member 20A increases expression EXP Ammonia results in increased expression of KIF20A mRNA CTD PMID:34389318 NCBI chr 2:140,202,316...140,213,144
Ensembl chr 2:140,202,015...140,211,155
JBrowse link
G KRAS KRAS proto-oncogene, GTPase increases expression EXP Ammonia results in increased expression of KRAS mRNA CTD PMID:34389318 NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358
JBrowse link
G LAX1 lymphocyte transmembrane adaptor 1 decreases expression EXP Ammonia results in decreased expression of LAX1 mRNA CTD PMID:34389318 NCBI chr 9:64,460,548...64,473,232
Ensembl chr 9:64,460,693...64,475,179
JBrowse link
G MBNL2 muscleblind like splicing regulator 2 decreases expression EXP Ammonia results in decreased expression of MBNL2 mRNA CTD PMID:34389318 NCBI chr11:66,481,923...66,641,653
Ensembl chr11:66,481,923...66,641,653
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like decreases expression EXP Ammonia results in decreased expression of MTHFD1L mRNA CTD PMID:34389318 NCBI chr 1:15,140,929...15,330,265
Ensembl chr 1:15,140,899...15,329,986
JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase increases expression EXP Ammonia results in increased expression of MTRR mRNA CTD PMID:34389318 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783
JBrowse link
G MYBBP1A MYB binding protein 1a decreases expression EXP Ammonia results in decreased expression of MYBBP1A mRNA CTD PMID:34389318 NCBI chr12:50,491,042...50,506,085
Ensembl chr12:50,491,044...50,506,050
JBrowse link
G NACC1 nucleus accumbens associated 1 decreases expression EXP Ammonia results in decreased expression of NACC1 mRNA CTD PMID:34389318 NCBI chr 2:65,920,352...65,938,840
Ensembl chr 2:65,922,126...65,938,759
JBrowse link
G NCOA1 nuclear receptor coactivator 1 increases expression EXP Ammonia results in increased expression of NCOA1 mRNA CTD PMID:34389318 NCBI chr 3:113,997,214...114,251,080
Ensembl chr 3:113,999,253...114,250,298
JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 decreases expression EXP Ammonia results in decreased expression of NEURL1 mRNA CTD PMID:34389318 NCBI chr14:114,436,887...114,515,713
Ensembl chr14:114,437,045...114,516,721
JBrowse link
G NFIX nuclear factor I X decreases expression EXP Ammonia results in decreased expression of NFIX mRNA CTD PMID:34389318 NCBI chr 2:65,954,808...66,056,591
Ensembl chr 2:65,954,811...66,056,567
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 increases expression EXP Ammonia results in increased expression of NR4A2 mRNA CTD PMID:34389318 NCBI chr15:63,487,051...63,506,249
Ensembl chr15:63,487,731...63,495,299
JBrowse link
G NREP neuronal regeneration related protein increases expression EXP Ammonia results in increased expression of NREP mRNA CTD PMID:34389318 NCBI chr 2:117,505,851...117,867,805
Ensembl chr 2:117,838,660...117,867,801
JBrowse link
G P4HA1 prolyl 4-hydroxylase subunit alpha 1 decreases expression EXP Ammonia results in decreased expression of P4HA1 mRNA CTD PMID:34389318 NCBI chr14:75,827,207...75,919,121
Ensembl chr14:75,825,148...75,919,016
JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline decreases expression EXP Ammonia results in decreased expression of PCYT1A mRNA CTD PMID:34389318 NCBI chr13:133,794,337...133,851,004
Ensembl chr13:133,818,761...133,850,996
JBrowse link
G PRAP1 proline rich acidic protein 1 decreases expression EXP Ammonia results in decreased expression of PRAP1 mRNA CTD PMID:34389318 NCBI chr14:141,325,965...141,329,955 JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C decreases expression EXP Ammonia results in decreased expression of PTPRC mRNA CTD PMID:34389318 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308
JBrowse link
G RALB RAS like proto-oncogene B increases expression EXP Ammonia results in increased expression of RALB mRNA CTD PMID:34389318 NCBI chr15:31,064,341...31,118,437
Ensembl chr15:31,064,355...31,122,621
JBrowse link
G RASL12 RAS like family 12 decreases expression EXP Ammonia results in decreased expression of RASL12 mRNA CTD PMID:34389318 NCBI chr 1:163,089,440...163,104,027
Ensembl chr 1:163,089,444...163,103,523
JBrowse link
G RBL2 RB transcriptional corepressor like 2 decreases expression EXP Ammonia results in decreased expression of RBL2 mRNA CTD PMID:34389318 NCBI chr 6:31,757,718...31,802,047
Ensembl chr 6:31,748,739...31,802,022
JBrowse link
G RBP4 retinol binding protein 4 increases expression EXP Ammonia results in increased expression of RBP4 mRNA CTD PMID:34389318 NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region decreases expression EXP Ammonia results in decreased expression of RBPJ mRNA CTD PMID:34389318 NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,754
JBrowse link
G RFC1 replication factor C subunit 1 decreases expression EXP Ammonia results in decreased expression of RFC1 mRNA CTD PMID:34389318 NCBI chr 8:30,552,369...30,635,932
Ensembl chr 8:30,552,400...30,635,867
JBrowse link
G SAL1 salivary lipocalin increases expression EXP Ammonia results in increased expression of SAL1 mRNA CTD PMID:34389318 NCBI chr 1:253,638,017...253,642,835
Ensembl chr 1:253,638,015...253,642,866
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP Ammonia results in decreased expression of SCD mRNA CTD PMID:34389318 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020
JBrowse link
G SFRP2 secreted frizzled related protein 2 decreases expression EXP Ammonia results in decreased expression of SFRP2 mRNA CTD PMID:34389318 NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,144...75,345,921
JBrowse link
G SFRP4 secreted frizzled related protein 4 decreases expression EXP Ammonia results in decreased expression of SFRP4 mRNA CTD PMID:34389318 NCBI chr 9:108,404,314...108,414,335
Ensembl chr 9:108,404,040...108,414,307
JBrowse link
G SLC13A4 solute carrier family 13 member 4 decreases expression EXP Ammonia results in decreased expression of SLC13A4 mRNA CTD PMID:34389318 NCBI chr18:13,593,735...13,641,649
Ensembl chr18:13,593,756...13,636,180
JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases expression EXP Ammonia results in increased expression of SLC22A7 mRNA CTD PMID:34389318 NCBI chr 7:38,328,474...38,334,879
Ensembl chr 7:38,328,419...38,334,878
JBrowse link
G SLC25A12 solute carrier family 25 member 12 increases expression EXP Ammonia results in increased expression of SLC25A12 mRNA CTD PMID:34389318 NCBI chr15:77,895,935...78,021,930
Ensembl chr15:77,895,938...78,098,383
JBrowse link
G SLC46A3 solute carrier family 46 member 3 decreases expression EXP Ammonia results in decreased expression of SLC46A3 mRNA CTD PMID:34389318 NCBI chr11:5,983,198...6,000,728
Ensembl chr11:5,982,443...6,000,701
JBrowse link
G SLC47A1 solute carrier family 47 member 1 increases expression EXP Ammonia results in increased expression of SLC47A1 mRNA CTD PMID:34389318 NCBI chr12:60,021,176...60,114,488
Ensembl chr12:60,021,188...60,056,938
JBrowse link
G SLC7A8 solute carrier family 7 member 8 decreases expression EXP Ammonia results in decreased expression of SLC7A8 mRNA CTD PMID:34389318 NCBI chr 7:75,854,700...75,921,931
Ensembl chr 7:75,854,882...75,921,931
JBrowse link
G SLC9A3 solute carrier family 9 member A3 decreases expression EXP Ammonia results in decreased expression of SLC9A3 mRNA CTD PMID:34389318 NCBI chr16:79,625,555...79,704,084
Ensembl chr16:79,666,825...79,700,658
JBrowse link
G SLIT2 slit guidance ligand 2 decreases expression EXP Ammonia results in decreased expression of SLIT2 mRNA CTD PMID:34389318 NCBI chr 8:14,758,426...15,149,515
Ensembl chr 8:14,758,335...15,149,510
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP Ammonia results in increased expression of SOD3 mRNA CTD PMID:34389318 NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,637...18,802,152
JBrowse link
G SORCS2 sortilin related VPS10 domain containing receptor 2 decreases expression EXP Ammonia results in decreased expression of SORCS2 mRNA CTD PMID:34389318 NCBI chr 8:3,207,087...3,715,002
Ensembl chr 8:3,207,098...3,760,393
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 increases expression EXP Ammonia results in increased expression of SRD5A2 mRNA CTD PMID:34389318 NCBI chr 3:107,840,200...107,918,351
Ensembl chr 3:107,840,200...107,918,350
JBrowse link
G ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 increases expression EXP Ammonia results in increased expression of ST3GAL6 mRNA CTD PMID:34389318 NCBI chr13:160,158,238...160,225,355
Ensembl chr13:160,158,259...160,224,819
JBrowse link
G TCEAL2 transcription elongation factor A like 2 decreases expression EXP Ammonia results in decreased expression of TCEAL2 mRNA CTD PMID:34389318 NCBI chr  X:83,577,181...83,582,946 JBrowse link
G TMEM33 transmembrane protein 33 increases expression EXP Ammonia results in increased expression of TMEM33 mRNA CTD PMID:34389318 NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993
JBrowse link
G TRAK2 trafficking kinesin protein 2 increases expression EXP Ammonia results in increased expression of TRAK2 mRNA CTD PMID:34389318 NCBI chr15:104,991,261...105,056,054
Ensembl chr15:104,991,726...105,055,025
JBrowse link
G TTC31 tetratricopeptide repeat domain 31 decreases expression EXP Ammonia results in decreased expression of TTC31 mRNA CTD PMID:34389318 NCBI chr 3:68,555,230...68,570,912
Ensembl chr 3:68,555,232...68,564,007
JBrowse link
G VPS36 vacuolar protein sorting 36 homolog decreases expression EXP Ammonia results in decreased expression of VPS36 mRNA CTD PMID:34389318 NCBI chr11:15,701,370...15,735,469
Ensembl chr11:15,701,373...15,735,474
JBrowse link
G VTN vitronectin increases expression EXP Ammonia results in increased expression of VTN mRNA CTD PMID:34389318 NCBI chr12:44,650,532...44,653,916
Ensembl chr12:44,650,534...44,655,355
JBrowse link
G WAPL WAPL cohesin release factor decreases expression EXP Ammonia results in decreased expression of WAPL mRNA CTD PMID:34389318 NCBI chr14:87,492,452...87,588,678
Ensembl chr14:87,492,458...87,588,543
JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta decreases expression EXP Ammonia results in decreased expression of YWHAZ mRNA CTD PMID:34389318 NCBI chr 4:35,975,513...36,009,909
Ensembl chr 4:35,975,508...36,009,887
JBrowse link
G ZNF24 zinc finger protein 24 decreases expression EXP Ammonia results in decreased expression of ZNF24 mRNA CTD PMID:34389318 NCBI chr 6:119,156,507...119,167,240
Ensembl chr 6:119,160,530...119,167,187
JBrowse link
G ZNF436 zinc finger protein 436 decreases expression EXP Ammonia results in decreased expression of ZNF436 mRNA CTD PMID:34389318 NCBI chr 6:81,250,203...81,262,346
Ensembl chr 6:81,250,629...81,262,351
JBrowse link
G ZNF79 zinc finger protein 79 increases expression EXP Ammonia results in increased expression of ZNF79 mRNA CTD PMID:34389318 NCBI chr 1:267,941,953...267,959,754
Ensembl chr 1:267,942,101...267,966,192
JBrowse link
amprenavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP amprenavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
bafilomycin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein] CTD PMID:36754226 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,556,710...98,623,940
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases lipidation
multiple interactions
EXP bafilomycin A1 results in increased lipidation of MAP1LC3B protein
bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]
CTD PMID:36754226 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
JBrowse link
BAPTA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; [Calcium co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased phosphorylation of MYL9 protein CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
JBrowse link
beauvericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 increases expression
decreases activity
EXP beauvericin results in increased expression of ABCB1 mRNA
beauvericin results in decreased activity of ABCB1 protein
CTD PMID:27474255 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 increases expression EXP beauvericin results in increased expression of CYP11A1 mRNA CTD PMID:27474255 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression EXP beauvericin results in increased expression of COX1 mRNA CTD PMID:27474255 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
Belnacasan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSDMD gasdermin D multiple interactions EXP belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein] CTD PMID:36309173 NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271
JBrowse link
G IL18 interleukin 18 multiple interactions EXP belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein] CTD PMID:36309173 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein] CTD PMID:36309173
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP benazepril results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity
multiple interactions
EXP Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]
CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458
JBrowse link
CAR(3:0(Me2)) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 decreases activity EXP pivaloylcarnitine results in decreased activity of SLC22A5 protein CTD PMID:16826461 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 decreases expression
increases expression
EXP Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein
CTD PMID:16824628 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177
JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression
EXP Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein
CTD PMID:16824628 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]
CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G JUP junction plakoglobin increases expression
decreases expression
EXP Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA
CTD PMID:16824628 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210
JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526
JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA] CTD PMID:27079946 NCBI chr14:101,237,403...101,249,486
Ensembl chr14:101,237,571...101,249,498
JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378
JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]
CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Chlorpromazine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
chlorpyrifos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP chlorpyrifos-methyl results in decreased activity of APEH protein CTD PMID:10953051 NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,518
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] CTD PMID:20435919 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G FASLG Fas ligand multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687
JBrowse link
clorgyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAOA monoamine oxidase A decreases activity EXP Clorgyline analog results in decreased activity of MAOA protein CTD PMID:33359020 NCBI chr  X:38,930,452...39,006,220 JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 decreases activity EXP Crizotinib results in decreased activity of NTRK1 protein CTD PMID:21812414 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 decreases activity EXP Crizotinib results in decreased activity of NTRK2 protein CTD PMID:21812414 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,008,719...7,071,025
JBrowse link
cyclosporin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization
EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein] CTD PMID:19523970 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G CASP6 caspase 6 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA] CTD PMID:19523970 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045
JBrowse link
G CYCS cytochrome c, somatic multiple interactions
affects localization
EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein] CTD PMID:23347876 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G EDN1 endothelin 1 increases secretion EXP Cyclosporine results in increased secretion of EDN1 protein CTD PMID:16391421 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein] CTD PMID:23347876 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028
JBrowse link
G MFN2 mitofusin 2 multiple interactions
decreases expression
EXP Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein] CTD PMID:23347876 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438
JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP Cyclosporine results in decreased expression of NOS3 protein CTD PMID:12695417 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase decreases expression
multiple interactions
EXP Cyclosporine results in decreased expression of OPA1 protein
Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]
CTD PMID:23347876 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083
JBrowse link
G RAC1 Rac family small GTPase 1 affects localization EXP Cyclosporine affects the localization of RAC1 protein CTD PMID:12695417 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543
JBrowse link
G SLC2A1 solute carrier family 2 member 1 decreases response to substance
multiple interactions
increases expression
EXP SLC2A1 protein results in decreased susceptibility to Cyclosporine
Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein]
Cyclosporine results in increased expression of SLC2A1 mRNA; Cyclosporine results in increased expression of SLC2A1 protein
CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867
JBrowse link
cysteamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Cysteamine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
daidzein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 increases expression EXP daidzein results in increased expression of ESR1 mRNA CTD PMID:19617652 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression EXP daidzein results in increased expression of ESR2 mRNA; daidzein results in increased expression of ESR2 protein CTD PMID:19617652 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP daidzein inhibits the reaction [LHB protein results in increased abundance of Progesterone] CTD PMID:19617652 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
diazinon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Diazinon results in decreased activity of ACHE protein CTD PMID:21467751 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605
JBrowse link
dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of ACHE protein CTD PMID:21467751 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605
JBrowse link
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP Dichlorvos results in decreased activity of APEH protein CTD PMID:10953051 NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,518
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr13:104,946,732...105,007,568 JBrowse link
dicoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]] CTD PMID:20732396 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
digitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP Digitoxin results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
JBrowse link
G CASP3 caspase 3 decreases cleavage EXP Digitoxin results in decreased cleavage of CASP3 protein CTD PMID:28438630 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP Digoxin results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
JBrowse link
dihydroouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases cleavage EXP dihydroouabain results in decreased cleavage of CASP3 protein CTD PMID:28438630 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
disulfiram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]; Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein] CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Disulfiram inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:10975995 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HK2 hexokinase 2 decreases expression EXP Dobutamine results in decreased expression of HK2 protein CTD PMID:19944370 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615
JBrowse link
G NOS2 nitric oxide synthase 2 affects response to substance EXP NOS2 protein affects the susceptibility to Dobutamine CTD PMID:20141602 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Dobutamine results in decreased expression of PYGM protein CTD PMID:19944370 NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,409,116...7,421,254
JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G OPRD1 opioid receptor delta 1 multiple interactions EXP Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [OPRD1 protein results in increased transport of Barium] CTD PMID:12031848 NCBI chr 6:85,775,576...85,827,170
Ensembl chr 6:85,785,276...85,830,877
JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552
JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116
JBrowse link
embelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions EXP [embelin results in increased uptake of Calcium] which results in increased activity of NOS3 protein CTD PMID:20144727 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Enalapril affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Enalaprilat results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G KNG1 kininogen 1 increases activity EXP Enalaprilat results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
JBrowse link
G LTA4H leukotriene A4 hydrolase decreases activity EXP Edetic Acid results in decreased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
folic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CBS cystathionine beta-synthase multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein
Folic Acid deficiency results in increased activity of CBS protein
CTD PMID:16792574 NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248
JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G CTH cystathionine gamma-lyase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein CTD PMID:16792574 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA CTD PMID:16792574 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases activity
increases expression
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA
Folic Acid deficiency results in increased activity of GSR protein
Folic Acid deficiency results in increased expression of GSR mRNA
CTD PMID:16792574 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
JBrowse link
G GSS glutathione synthetase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA CTD PMID:16792574 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,298
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
JBrowse link
G LOC106504562 glutathione S-transferase alpha M14 increases expression
multiple interactions
EXP Folic Acid deficiency results in increased expression of GSTA1 mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA
CTD PMID:16792574 NCBI chr 7:46,553,813...46,567,596 JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity
multiple interactions
EXP Folic Acid deficiency results in decreased activity of SOD1 protein
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA; [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
CTD PMID:16792574 PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Folic Acid deficiency results in increased activity of SOD2 protein; Folic Acid results in increased activity of SOD2 protein
CTD PMID:16792574 PMID:22889112 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
fucoidan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:21948611 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
fumonisin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor increases expression EXP fumonisin B1 results in increased expression of AGER mRNA CTD PMID:32198028 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
EXP fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 protein]
fumonisin B1 results in increased expression of APAF1 mRNA; fumonisin B1 results in increased expression of APAF1 protein
CTD PMID:36397609 NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]
fumonisin B1 results in increased expression of BAX mRNA; fumonisin B1 results in increased expression of BAX protein
CTD PMID:33905761 PMID:36397609 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP fumonisin B1 results in decreased expression of BCL2 mRNA; fumonisin B1 results in decreased expression of BCL2 protein
[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 protein]; fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]; Zearalenone inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]
CTD PMID:29109043 PMID:33905761 PMID:36397609 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions EXP N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP1 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP1 protein] CTD PMID:36309173 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP10 caspase 10 multiple interactions
increases expression
EXP 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP10 mRNA] CTD PMID:32198028 NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
EXP 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form; [fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]
fumonisin B1 results in increased expression of CASP3 mRNA; fumonisin B1 results in increased expression of CASP3 protein; fumonisin B1 results in increased expression of CASP3 protein modified form
CTD PMID:29109043 PMID:32198028 PMID:33905761 PMID:36397609 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP8 mRNA] CTD PMID:32198028 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression
EXP [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]
fumonisin B1 results in increased expression of CASP9 mRNA; fumonisin B1 results in increased expression of CASP9 protein; fumonisin B1 results in increased expression of CASP9 protein modified form
CTD PMID:33905761 PMID:36397609 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]
fumonisin B1 results in decreased expression of CCL2 mRNA
fumonisin B1 metabolite results in increased expression of CCL2 mRNA; fumonisin B1 results in increased expression of CCL2 mRNA
CTD PMID:23688591 PMID:30708112 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of CCL20 mRNA
fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]
CTD PMID:30708112 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex increases expression EXP fumonisin B1 results in increased expression of CHUK mRNA CTD PMID:32198028 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868
JBrowse link
G CLDN1 claudin 1 decreases expression EXP fumonisin B1 results in decreased expression of CLDN1 mRNA; fumonisin B1 results in decreased expression of CLDN1 protein CTD PMID:31557363 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]
fumonisin B1 results in increased expression of CXCL8 mRNA
CTD PMID:23688591 PMID:30708112 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CYCS mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA] CTD PMID:29109043 PMID:36397609 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G GSDMD gasdermin D multiple interactions EXP belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein] CTD PMID:36309173 NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions EXP [fumonisin B1 co-treated with ochratoxin A] results in increased expression of HAVCR1 mRNA CTD PMID:33905761 NCBI chr16:66,162,318...66,208,868 JBrowse link
G IFNG interferon gamma decreases expression EXP fumonisin B1 metabolite results in decreased expression of IFNG protein CTD PMID:30708112 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
JBrowse link
G IL17A interleukin 17A multiple interactions EXP fumonisin B1 inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein] CTD PMID:30708112 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL18 interleukin 18 multiple interactions EXP belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein] CTD PMID:36309173 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
JBrowse link
G IL1A interleukin 1 alpha multiple interactions
increases expression
decreases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in decreased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA
fumonisin B1 results in increased expression of IL1A mRNA
fumonisin B1 results in decreased expression of IL1A mRNA
CTD PMID:23688591 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in decreased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA
fumonisin B1 results in decreased expression of IL6 mRNA
fumonisin B1 results in increased expression of IL6 mRNA
CTD PMID:23688591 PMID:30708112 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G LCN2 lipocalin 2 multiple interactions EXP [fumonisin B1 co-treated with ochratoxin A] results in increased expression of LCN2 mRNA CTD PMID:33905761 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of IL1B mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]
CTD PMID:23688591 PMID:36309173
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 increases expression EXP fumonisin B1 results in increased expression of MAP3K14 mRNA CTD PMID:32198028 NCBI chr12:18,142,899...18,182,931
Ensembl chr12:18,142,952...18,182,928
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP fumonisin B1 results in increased phosphorylation of MAPK1 protein CTD PMID:31557363 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK10 mitogen-activated protein kinase 10 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of MAPK10 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK10 mRNA]
CTD PMID:32198028 NCBI chr 8:132,445,818...132,751,575
Ensembl chr 8:132,298,299...132,776,820
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP fumonisin B1 results in increased phosphorylation of MAPK3 protein CTD PMID:31557363 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of MAPK8 mRNA; fumonisin B1 results in increased expression of MAPK8 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 protein]
CTD PMID:32198028 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of MAPK9 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK9 mRNA]
CTD PMID:32198028 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
JBrowse link
G MUC1 mucin 1, cell surface associated decreases expression EXP fumonisin B1 results in decreased expression of MUC1 mRNA CTD PMID:31557363 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming increases expression EXP fumonisin B1 results in increased expression of MUC2 mRNA CTD PMID:31557363 NCBI chr 2:689,363...719,542
Ensembl chr 2:689,364...710,330
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of NFKB1 mRNA; fumonisin B1 results in increased expression of NFKB1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 protein]
CTD PMID:32198028 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
JBrowse link
G NTN1 netrin 1 multiple interactions EXP fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of NTN1 mRNA] CTD PMID:33905761 NCBI chr12:54,089,444...54,292,191
Ensembl chr12:54,089,472...54,292,193
JBrowse link
G OCLN occludin decreases expression EXP fumonisin B1 results in decreased expression of OCLN mRNA; fumonisin B1 results in decreased expression of OCLN protein CTD PMID:31557363 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G SLC15A1 solute carrier family 15 member 1 increases expression EXP fumonisin B1 results in increased expression of SLC15A1 mRNA CTD PMID:33443779 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC1A1 solute carrier family 1 member 1 decreases expression EXP fumonisin B1 results in decreased expression of SLC1A1 mRNA CTD PMID:33443779 NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674
JBrowse link
G SLC27A4 solute carrier family 27 member 4 decreases expression EXP fumonisin B1 results in decreased expression of SLC27A4 mRNA CTD PMID:33443779 NCBI chr 1:268,773,792...268,788,208
Ensembl chr 1:268,773,806...268,788,731
JBrowse link
G SLC2A2 solute carrier family 2 member 2 decreases expression EXP fumonisin B1 results in decreased expression of SLC2A2 mRNA CTD PMID:33443779 NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510
JBrowse link
G SLC7A1 solute carrier family 7 member 1 decreases expression EXP fumonisin B1 results in decreased expression of SLC7A1 mRNA CTD PMID:33443779 NCBI chr11:6,538,053...6,604,654
Ensembl chr11:6,538,045...6,604,658
JBrowse link
G SLC7A7 solute carrier family 7 member 7 decreases expression EXP fumonisin B1 results in decreased expression of SLC7A7 mRNA CTD PMID:33443779 NCBI chr 7:76,195,774...76,235,406
Ensembl chr 7:76,198,256...76,235,402
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of SPP1 mRNA
fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of SPP1 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of SPP1 mRNA]
CTD PMID:33905761 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP fumonisin B1 results in decreased expression of TJP1 mRNA; fumonisin B1 results in decreased expression of TJP1 protein CTD PMID:31557363 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF protein; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA
fumonisin B1 results in increased expression of TNF mRNA; fumonisin B1 results in increased expression of TNF protein
CTD PMID:23688591 PMID:30708112 PMID:32198028 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of TP53 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]
CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
G TRADD TNFRSF1A associated via death domain increases expression EXP fumonisin B1 results in increased expression of TRADD mRNA CTD PMID:32198028 NCBI chr 6:27,797,594...27,804,654
Ensembl chr 6:27,797,607...27,804,423
JBrowse link
G TRAF2 TNF receptor associated factor 2 increases expression EXP fumonisin B1 results in increased expression of TRAF2 mRNA CTD PMID:32198028
gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Gabapentin binds to CACNA2D1 protein CTD PMID:11687876 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,781,090...98,266,969
JBrowse link
gefitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FES FES proto-oncogene, tyrosine kinase multiple interactions
decreases phosphorylation
EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]
Gefitinib results in decreased phosphorylation of FES protein
CTD PMID:19885553 NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,947...53,485,082
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in increased expression of AOC1 protein] CTD PMID:36615853 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B multiple interactions EXP [Glutathione co-treated with Paraquat] results in decreased expression of CYP2B6B mRNA CTD PMID:36615853 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334
JBrowse link
G CYP3A39 cytochrome P450 3A39 multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in increased expression of CYP3A39 mRNA] CTD PMID:36615853
G DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 multiple interactions EXP [Glutathione co-treated with Paraquat] results in increased expression of DNAJC7 mRNA CTD PMID:36615853 NCBI chr12:20,725,937...20,756,295
Ensembl chr12:20,725,975...20,759,000
JBrowse link
G FABP2 fatty acid binding protein 2 multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein] CTD PMID:36615853 NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP [Glutathione co-treated with Paraquat] results in increased expression of GCLM mRNA CTD PMID:36615853 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP [Glutathione co-treated with Paraquat] results in increased expression of GPX4 mRNA CTD PMID:36615853 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP [Glutathione co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA CTD PMID:36615853
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
JBrowse link
G IFNG interferon gamma multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in increased expression of IFNG mRNA] CTD PMID:36615853 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [Glutathione co-treated with Paraquat] results in increased expression of IL10 mRNA CTD PMID:36615853 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
JBrowse link
G LOC100739508 glutathione S-transferase P-like multiple interactions EXP GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] CTD PMID:14573868 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G LOC106504562 glutathione S-transferase alpha M14 multiple interactions EXP [Glutathione co-treated with Paraquat] results in increased expression of GSTA2 mRNA; Glutathione inhibits the reaction [Paraquat results in decreased expression of GSTA1 mRNA] CTD PMID:36615853 NCBI chr 7:46,553,813...46,567,596 JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in increased expression of NR1I3 mRNA] CTD PMID:36615853 NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431
JBrowse link
G OCLN occludin multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in decreased expression of OCLN protein] CTD PMID:36615853 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP [Glutathione co-treated with Paraquat] affects the expression of SOD2 mRNA CTD PMID:36615853 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TJP1 tight junction protein 1 multiple interactions EXP Glutathione inhibits the reaction [Paraquat results in decreased expression of TJP1 protein] CTD PMID:36615853 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein] CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
glycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of ATF4 protein] CTD PMID:36584959 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of ATF6 mRNA] CTD PMID:36584959 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [Betaine co-treated with glyphosate] results in increased expression of BAX mRNA CTD PMID:36584959 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of CASP3 mRNA] CTD PMID:36584959 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of CASP9 mRNA] CTD PMID:36584959 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein; Betaine inhibits the reaction [glyphosate results in increased expression of CAT mRNA] CTD PMID:29129240 PMID:36584959 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CLDN1 claudin 1 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [glyphosate results in decreased expression of CLDN1 protein] CTD PMID:36584959 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of DDIT3 mRNA] CTD PMID:36584959 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of EIF2AK3 protein] CTD PMID:36584959 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of EIF2S1 protein] CTD PMID:36584959 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of ERN1 mRNA] CTD PMID:36584959 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions EXP [Betaine co-treated with glyphosate] results in increased expression of GPX2 mRNA CTD PMID:36584959 NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of HSP90B1 protein] CTD PMID:36584959 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
JBrowse link
G MFN1 mitofusin 1 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of MFN1 mRNA] CTD PMID:36584959 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of NFE2L2 mRNA] CTD PMID:36584959 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of NQO1 mRNA] CTD PMID:36584959 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of PCNA protein] CTD PMID:36584959 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744
JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of SDHA mRNA] CTD PMID:36584959 NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of SOD2 mRNA] CTD PMID:36584959 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G UQCRB ubiquinol-cytochrome c reductase binding protein multiple interactions EXP [Betaine co-treated with glyphosate] results in decreased expression of UQCRB mRNA CTD PMID:36584959 NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057
JBrowse link
G XBP1 X-box binding protein 1 multiple interactions EXP Betaine inhibits the reaction [glyphosate results in increased expression of XBP1 mRNA] CTD PMID:36584959 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
JBrowse link
glyphosate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression
multiple interactions
EXP glyphosate results in increased expression of ATF4 mRNA; glyphosate results in increased expression of ATF4 protein
Betaine inhibits the reaction [glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of ATF4 protein]
CTD PMID:36584959 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G ATF6 activating transcription factor 6 increases expression
multiple interactions
EXP glyphosate results in increased expression of ATF6 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of ATF6 mRNA]
CTD PMID:36584959 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [Betaine co-treated with glyphosate] results in increased expression of BAX mRNA
glyphosate results in increased expression of BAX mRNA
CTD PMID:36584959 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
EXP glyphosate results in increased expression of CASP3 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of CASP3 mRNA]
CTD PMID:36584959 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP9 caspase 9 increases expression
multiple interactions
EXP glyphosate results in increased expression of CASP9 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of CASP9 mRNA]
CTD PMID:36584959 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CAT catalase increases activity
multiple interactions
increases expression
EXP glyphosate results in increased activity of CAT protein
Betaine inhibits the reaction [glyphosate results in increased expression of CAT mRNA]
CTD PMID:31677563 PMID:36584959 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CLDN1 claudin 1 decreases expression
multiple interactions
EXP glyphosate results in decreased expression of CLDN1 mRNA; glyphosate results in decreased expression of CLDN1 protein
Betaine inhibits the reaction [glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [glyphosate results in decreased expression of CLDN1 protein]
CTD PMID:31677563 PMID:36584959 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
EXP glyphosate results in increased expression of CXCL8 mRNA
pyrrolidine dithiocarbamic acid inhibits the reaction [glyphosate results in increased expression of CXCL8 mRNA]
CTD PMID:35388968 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression
EXP Betaine inhibits the reaction [glyphosate results in increased expression of DDIT3 mRNA] CTD PMID:36584959 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions
EXP glyphosate results in increased expression of EIF2AK3 mRNA; glyphosate results in increased expression of EIF2AK3 protein
Betaine inhibits the reaction [glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of EIF2AK3 protein]
CTD PMID:36584959 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases expression
EXP Betaine inhibits the reaction [glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of EIF2S1 protein]
glyphosate results in increased expression of EIF2S1 mRNA; glyphosate results in increased expression of EIF2S1 protein
CTD PMID:36584959 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
EXP Betaine inhibits the reaction [glyphosate results in increased expression of ERN1 mRNA] CTD PMID:36584959 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases expression EXP glyphosate results in decreased expression of GCLM mRNA CTD PMID:31677563 PMID:35388968 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression
decreases activity
EXP glyphosate results in decreased expression of GPX1 mRNA
glyphosate results in decreased activity of GPX1 protein
CTD PMID:31677563 PMID:35388968 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions EXP [Betaine co-treated with glyphosate] results in increased expression of GPX2 mRNA CTD PMID:36584959 NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620
JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases expression EXP glyphosate results in increased expression of GSTO1 mRNA CTD PMID:36584959 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
multiple interactions
increases expression
EXP glyphosate results in decreased expression of HMOX1 mRNA
glyphosate results in increased expression of and affects the localization of HMOX1 protein
glyphosate results in increased expression of HMOX1 mRNA
CTD PMID:31677563 PMID:35388968 PMID:36584959
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
multiple interactions
EXP glyphosate results in increased expression of HSP90B1 mRNA; glyphosate results in increased expression of HSP90B1 protein
Betaine inhibits the reaction [glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of HSP90B1 protein]
CTD PMID:36584959 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G IL10 interleukin 10 increases expression EXP glyphosate results in increased expression of IL10 protein CTD PMID:36584959 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
affects secretion
EXP glyphosate results in increased expression of IL6 mRNA; glyphosate results in increased expression of IL6 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [glyphosate results in increased expression of IL6 mRNA]
glyphosate affects the secretion of IL6 protein
CTD PMID:31677563 PMID:35388968 PMID:36584959 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G KEAP1 kelch like ECH associated protein 1 decreases expression EXP glyphosate results in decreased expression of KEAP1 mRNA CTD PMID:35388968 NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions
increases expression
increases secretion
EXP pyrrolidine dithiocarbamic acid inhibits the reaction [glyphosate results in increased expression of IL1B mRNA]
glyphosate results in increased expression of IL1B mRNA; glyphosate results in increased expression of IL1B protein
glyphosate results in increased secretion of IL1B protein
CTD PMID:35388968 PMID:36584959
G MFN1 mitofusin 1 multiple interactions
increases expression
EXP Betaine inhibits the reaction [glyphosate results in increased expression of MFN1 mRNA] CTD PMID:36584959 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
EXP glyphosate results in increased expression of NFE2L2 mRNA; glyphosate results in increased expression of NFE2L2 protein
Betaine inhibits the reaction [glyphosate results in increased expression of NFE2L2 mRNA]; glyphosate results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:31677563 PMID:35388968 PMID:36584959 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression EXP glyphosate results in increased expression of NFKB1 mRNA CTD PMID:31677563 PMID:35388968 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP glyphosate results in decreased expression of and results in increased phosphorylation of NFKBIA protein CTD PMID:35388968 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression EXP glyphosate results in increased expression of NOS2 mRNA CTD PMID:35388968 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP glyphosate results in increased expression of NQO1 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of NQO1 mRNA]
CTD PMID:31677563 PMID:35388968 PMID:36584959 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression
multiple interactions
EXP glyphosate results in increased expression of PCNA mRNA; glyphosate results in increased expression of PCNA protein
Betaine inhibits the reaction [glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [glyphosate results in increased expression of PCNA protein]
CTD PMID:36584959 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases phosphorylation EXP glyphosate results in increased phosphorylation of RELA protein CTD PMID:35388968 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A increases expression
multiple interactions
EXP glyphosate results in increased expression of SDHA mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of SDHA mRNA]
CTD PMID:36584959 NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP glyphosate results in decreased activity of SOD1 protein CTD PMID:35388968 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 increases expression
multiple interactions
EXP glyphosate results in increased expression of SOD2 mRNA
Betaine inhibits the reaction [glyphosate results in increased expression of SOD2 mRNA]
CTD PMID:36584959 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [glyphosate results in decreased expression of SQSTM1 protein] CTD PMID:35388968 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP glyphosate results in decreased expression of TJP1 mRNA CTD PMID:31677563 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
G TNF tumor necrosis factor affects secretion
increases expression
EXP glyphosate affects the secretion of TNF protein
glyphosate results in increased expression of TNF protein
CTD PMID:35388968 PMID:36584959 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G UQCRB ubiquinol-cytochrome c reductase binding protein multiple interactions EXP [Betaine co-treated with glyphosate] results in decreased expression of UQCRB mRNA CTD PMID:36584959 NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057
JBrowse link
G XBP1 X-box binding protein 1 multiple interactions
increases expression
EXP Betaine inhibits the reaction [glyphosate results in increased expression of XBP1 mRNA] CTD PMID:36584959 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
JBrowse link
histamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HRH2 histamine receptor H2 multiple interactions EXP [Histamine affects the activity of HRH2 protein] which affects the secretion of Chlorides CTD PMID:12665126 NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,673...81,932,275
JBrowse link
hypochlorous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions EXP Hypochlorous Acid inhibits the reaction [NOS3 protein binds to NOS3 protein] CTD PMID:17762155 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
icatibant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 decreases activity EXP icatibant results in decreased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
imipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Imipramine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944
JBrowse link
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain multiple interactions
decreases expression
EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein
CTD PMID:21307347 NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,614
JBrowse link
G COL4A3 collagen type IV alpha 3 chain decreases expression
multiple interactions
EXP KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]
CTD PMID:21307347 NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122
JBrowse link
G ITGAV integrin subunit alpha V multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,851
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292
JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT2 AKT serine/threonine kinase 2 increases expression EXP Malathion results in increased expression of AKT2 mRNA CTD PMID:31535366 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Malathion results in increased expression of BAX mRNA CTD PMID:31535366 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP Malathion results in decreased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CAT catalase decreases expression
multiple interactions
EXP Malathion results in decreased expression of CAT mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]
CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression EXP Malathion results in decreased expression of CYP1A1 mRNA CTD PMID:31535366 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression EXP Malathion results in decreased expression of CYP1B1 mRNA CTD PMID:31535366 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683
JBrowse link
G DUOX2 dual oxidase 2 decreases expression EXP Malathion results in decreased expression of DUOX2 mRNA CTD PMID:31535366 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406
JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Malathion results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
G GPX6 glutathione peroxidase 6 increases expression EXP Malathion results in increased expression of GPX6 mRNA CTD PMID:31535366 NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992
JBrowse link
G LOC106504562 glutathione S-transferase alpha M14 decreases expression EXP Malathion results in decreased expression of GSTA1 mRNA CTD PMID:31535366 NCBI chr 7:46,553,813...46,567,596 JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I affects expression EXP Malathion affects the expression of COX1 mRNA CTD PMID:17454254 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III affects expression EXP Malathion affects the expression of COX3 mRNA CTD PMID:17454254 NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583
JBrowse link
G PLIN2 perilipin 2 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]
Malathion results in decreased expression of PLIN2 mRNA; Malathion results in decreased expression of PLIN2 protein
CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]
Malathion results in decreased expression of PPARG mRNA; Malathion results in decreased expression of PPARG protein
CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G SLC34A2 solute carrier family 34 member 2 increases expression EXP Malathion results in increased expression of SLC34A2 mRNA CTD PMID:31535366 NCBI chr 8:19,481,127...19,507,903
Ensembl chr 8:19,481,198...19,509,666
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Malathion results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G SORD sorbitol dehydrogenase increases expression EXP Malathion results in increased expression of SORD mRNA CTD PMID:31535366 NCBI chr 1:126,659,198...126,701,084
Ensembl chr 1:126,655,156...126,701,138
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Malathion results in increased expression of TP53 mRNA
Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELE selectin E increases expression EXP mastoparan results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX protein] CTD PMID:35665993 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
Melatonin results in increased expression of BCL2 mRNA
CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CASP3 caspase 3 decreases expression
multiple interactions
EXP Melatonin results in decreased expression of CASP3 mRNA
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 protein]
CTD PMID:31535366 PMID:35665993 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 protein] CTD PMID:35665993 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 protein] CTD PMID:35665993 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CAT catalase multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA] CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G COX7A2L cytochrome c oxidase subunit 7A2 like multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of COX7A2L mRNA] CTD PMID:35665993 NCBI chr 3:97,951,115...97,983,309
Ensembl chr 3:97,951,114...97,983,309
JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Melatonin results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL protein] CTD PMID:35665993 NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173
JBrowse link
G PLIN2 perilipin 2 multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein] CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein] CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN protein] CTD PMID:35665993 NCBI chr14:99,929,590...100,021,619 JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 protein] CTD PMID:35665993 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699
JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 multiple interactions EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 protein] CTD PMID:35665993 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Melatonin results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TP53 tumor protein p53 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Melatonin results in decreased expression of TP53 mRNA
CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 decreases response to substance EXP IL4 protein results in decreased susceptibility to Melitten CTD PMID:20017192 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G PLA2G1B phospholipase A2 group IB increases activity EXP Melitten results in increased activity of PLA2G1B protein CTD PMID:9092818 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315
JBrowse link
G SELE selectin E increases expression EXP Melitten results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
menadione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 multiple interactions
increases activity
EXP SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein] CTD PMID:18086661 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G CAPN2 calpain 2 increases expression
increases cleavage
EXP Vitamin K 3 results in increased expression of CAPN2 protein
Vitamin K 3 results in increased cleavage of CAPN2 protein
CTD PMID:16920763 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,757...19,820,246
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
EXP PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSP90B1 protein]
Vitamin K 3 results in increased expression of HSP90B1 mRNA; Vitamin K 3 results in increased expression of HSP90B1 protein
CTD PMID:16920763 PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]
Vitamin K 3 results in increased expression of HSPA5 mRNA; Vitamin K 3 results in increased expression of HSPA5 protein
CTD PMID:16920763 PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Vitamin K 3 results in increased phosphorylation of MAPK8 protein CTD PMID:18086661 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G SOD2 superoxide dismutase 2 decreases response to substance
multiple interactions
EXP SOD2 results in decreased susceptibility to Vitamin K 3
SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein]
CTD PMID:18086661 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TPO thyroid peroxidase decreases activity EXP Vitamin K 3 results in decreased activity of TPO protein CTD PMID:11815678 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
JBrowse link
G XBP1 X-box binding protein 1 increases splicing EXP Vitamin K 3 results in increased splicing of XBP1 mRNA CTD PMID:18086661 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2C 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
EXP mesulergine binds to HTR2C protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD PMID:11927170 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,355
JBrowse link
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA5 annexin A5 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]] CTD PMID:10617950 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G CASP3 caspase 3 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein] CTD PMID:14519784 PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA]
CTD PMID:18845708 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA] CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein
caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA]
CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G SELE selectin E multiple interactions
increases expression
EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA] CTD PMID:18845708 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G TNF tumor necrosis factor multiple interactions
increases activity
EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
N,N-dimethylaniline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of N,N-dimethylaniline CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 PMID:33905761 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]] CTD PMID:19135140 PMID:29109043 PMID:33905761 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G BMP15 bone morphogenetic protein 15 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA] CTD PMID:26386189 NCBI chr  X:44,613,122...44,620,575
Ensembl chr  X:44,613,122...44,620,575
JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein] CTD PMID:36281498 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]] CTD PMID:17383151 PMID:19135140 PMID:29109043 PMID:33905761 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 PMID:33905761 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CAT catalase multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA] CTD PMID:36281498 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] CTD PMID:18086661 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA] CTD PMID:36281498 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA] CTD PMID:36281498 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
G GSDMD gasdermin D multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein] CTD PMID:36281498 NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA] CTD PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein] CTD PMID:36281498
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:17383151 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein] CTD PMID:36281498 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of INOS mRNA] CTD PMID:36281498 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PTGS2 mRNA] CTD PMID:36281498 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA] CTD PMID:26386189 NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions EXP Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein] CTD PMID:36281498 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP Acetylcysteine inhibits the reaction [glyphosate results in decreased expression of SQSTM1 protein] CTD PMID:35388968 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA] CTD PMID:26386189 NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]] CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
G ZP3 zona pellucida glycoprotein 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA] CTD PMID:26386189 NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
JBrowse link
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKT1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]
CTD PMID:16239170
G CLIC5 chloride intracellular channel 5 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein] CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein] CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOS3 protein
CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXO1 forkhead box O1 increases expression EXP Niacinamide results in increased expression of FOXO1 mRNA CTD PMID:17851734 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression EXP Niacinamide results in increased expression of PPARG mRNA CTD PMID:17851734 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G SIRT1 sirtuin 1 decreases expression EXP Niacinamide results in decreased expression of SIRT1 mRNA CTD PMID:17851734 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297
JBrowse link
nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294
JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301
JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion
EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein
CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123
JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
G CYP19A3 cytochrome P450 19A3 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion
EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein
CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326
JBrowse link
G