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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
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Accession:CHEBI:76744 term browser browse the term
Definition:An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on CH or CH2 (EC 1.17.*.*).
Synonyms:related_synonym: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors;   EC 1.17.* inhibitor;   EC 1.17.* inhibitors;   oxidoreductase acting on CH or CH2 inhibitor;   oxidoreductase acting on CH or CH2 inhibitors


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6-formylpterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist decreases expression ISO 2-amino-4-hydroxy-6-formylpteridine results in decreased expression of BID protein CTD PMID:16019850 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 increases activity ISO 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP3 protein CTD PMID:16019850 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP8 protein CTD PMID:16019850 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 2-amino-4-hydroxy-6-formylpteridine affects the localization of CYCS protein CTD PMID:16019850 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Prkcd protein kinase C, delta affects localization ISO 2-amino-4-hydroxy-6-formylpteridine affects the localization of PRKCD protein CTD PMID:16019850 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
allopurinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of ABCB11 mRNA CTD PMID:33749747 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 protein]; Allopurinol inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 PMID:34687833 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
increases expression		 ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ACADM mRNA]
Allopurinol results in increased expression of ACADM mRNA		 CTD PMID:33749747 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression		 ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ACOX1 mRNA]
Allopurinol results in increased expression of ACOX1 mRNA		 CTD PMID:33749747 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]] CTD PMID:21912612 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] CTD PMID:21912612 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 PMID:19145780 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Allopurinol results in increased expression of ALDH1A1 mRNA CTD PMID:28138970 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Allopurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Allopurinol results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957 		JBrowse link
G Apob apolipoprotein B decreases secretion
decreases expression
multiple interactions		 ISO Allopurinol results in decreased secretion of APOB protein
Allopurinol results in decreased expression of APOB mRNA
ursodoxicoltaurine inhibits the reaction [Allopurinol results in decreased secretion of APOB protein]		 CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc3 apolipoprotein C3 decreases secretion
decreases expression		 ISO Allopurinol results in decreased secretion of APOC3 protein
Allopurinol results in decreased expression of APOC3 mRNA		 CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Allopurinol results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Allopurinol inhibits the reaction [fipronil results in increased expression of BAX mRNA] CTD PMID:36916050 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Allopurinol inhibits the reaction [fipronil results in decreased expression of BCL2 mRNA] CTD PMID:36916050 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Allopurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 protein]		 CTD PMID:22426011 PMID:23647015 PMID:24491314 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Allopurinol inhibits the reaction [fipronil results in increased expression of CASP3 mRNA] CTD PMID:36916050 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Allopurinol inhibits the reaction [fipronil results in increased activity of CAT protein]; Allopurinol inhibits the reaction [Indomethacin results in decreased activity of CAT protein] CTD PMID:12566098 PMID:36916050 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]
Allopurinol inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]		 CTD PMID:15689417 PMID:19158351 PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Cd36 CD36 molecule increases expression
decreases expression		 EXP
ISO		 Allopurinol results in increased expression of CD36 mRNA
Allopurinol results in decreased expression of CD36 mRNA		 CTD PMID:28138970 PMID:32535746 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein] CTD PMID:22648416 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ckm creatine kinase, M-type decreases secretion EXP Allopurinol results in decreased secretion of CKM protein CTD PMID:21912612 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CPT2 mRNA] CTD PMID:33749747 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of CYP7A1 mRNA CTD PMID:33749747 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of CYP8B1 mRNA CTD PMID:33749747 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Allopurinol results in increased expression of DDIT3 mRNA CTD PMID:32535746 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Allopurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Allopurinol results in increased expression of ERN1 mRNA CTD PMID:32535746 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN protein]		 CTD PMID:23647015 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in increased expression of FN1 protein] CTD PMID:22648416 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Allopurinol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein] CTD PMID:24491314 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GPX2 mRNA CTD PMID:33749747 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of GSR protein] CTD PMID:12566098 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GSTA1 mRNA CTD PMID:33749747 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GSTM3 mRNA CTD PMID:33749747 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of HADHA mRNA] CTD PMID:33749747 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Allopurinol inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]
Allopurinol results in increased expression of HMOX1 mRNA		 CTD PMID:20888885 PMID:22659318 PMID:25091725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Allopurinol results in increased expression of HSPA5 mRNA CTD PMID:32535746 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein] CTD PMID:28949055 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein] CTD PMID:24491314 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:22426011 PMID:23647015 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO
EXP		 Allopurinol results in decreased expression of IL1B mRNA
[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of IL1B mRNA
Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]		 CTD PMID:7695923 PMID:22426011 PMID:23647015 PMID:24491314 PMID:33749747 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]
Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]		 CTD PMID:15689417 PMID:21912612 PMID:22426011 PMID:23867654 PMID:33749747 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of INS1 protein]; Allopurinol inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:19605544 PMID:22426011 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Insr insulin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011 PMID:24491314 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Lep leptin multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Allopurinol results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:26641773 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Allopurinol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] CTD PMID:15650392 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Allopurinol results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:26641773 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Allopurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:12566098 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Allopurinol results in decreased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Allopurinol inhibits the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]
Allopurinol inhibits the reaction [Oxonic Acid affects the localization of NFAT5 protein]		 CTD PMID:23867654 PMID:30651350 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein] CTD PMID:24491314 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]		 CTD PMID:22426011 PMID:23647015 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NOS2 mRNA CTD PMID:33749747 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Allopurinol inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]] CTD PMID:21912612 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NQO1 mRNA CTD PMID:33749747 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NR0B2 mRNA CTD PMID:33749747 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP
ISO		 Allopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein] CTD PMID:23647015 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression ISO Allopurinol results in decreased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression		 ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]
Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of PPARA protein]
Allopurinol results in increased expression of PPARA protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA protein]		 CTD PMID:22426011 PMID:23647015 PMID:33749747 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO		 Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD protein] CTD PMID:22426011 PMID:23647015 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]		 CTD PMID:24491314 PMID:28949055 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:33749747 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc17a1 solute carrier family 17 member 1 multiple interactions ISO Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 protein] CTD PMID:34687833 NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 protein]; Allopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 PMID:34687833 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:21909718 PMID:22865646 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]		 CTD PMID:21909718 PMID:22426011 PMID:22865646 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 protein]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 PMID:34687833 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport
increases uptake		 ISO SLC22A7 protein results in increased transport of Allopurinol
SLC22A7 protein results in increased uptake of Allopurinol		 CTD PMID:12065749 PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Allopurinol CTD PMID:15100168 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of SLC51B mRNA CTD PMID:33749747 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO Allopurinol inhibits the reaction [Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]] CTD PMID:23867654 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of SLCO1B2 mRNA CTD PMID:33749747 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]		 CTD PMID:23647015 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]		 CTD PMID:23647015 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] CTD PMID:18322232 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]] CTD PMID:21912612 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects activity EXP Allopurinol affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tnf tumor necrosis factor increases chemical synthesis
multiple interactions
increases expression		 ISO
EXP		 TNF protein results in increased chemical synthesis of Allopurinol
[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of TNF mRNA; [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of TNF protein
Allopurinol results in increased expression of TNF mRNA
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of TNF mRNA]
Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]		 CTD PMID:7695923 PMID:22426011 PMID:26641773 PMID:28949055 PMID:33749747 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]		 CTD PMID:23647015 PMID:24491314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Umod uromodulin multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate affects the expression of UMOD protein]; Allopurinol inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA] CTD PMID:21909718 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity
multiple interactions
affects activity		 ISO
EXP		 Allopurinol results in decreased activity of XDH protein
Allopurinol inhibits the reaction [[Streptozocin affects the activity of XDH protein] which results in increased chemical synthesis of Hydrogen Peroxide]; Allopurinol inhibits the reaction [fipronil results in increased activity of XDH protein]; Allopurinol inhibits the reaction [Indomethacin results in increased activity of XDH protein]; Allopurinol inhibits the reaction [Streptozocin affects the activity of XDH protein]; Allopurinol inhibits the reaction [XDH protein results in increased oxidation of Quinoxalines]
Allopurinol affects the activity of XDH protein
[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of XDH mRNA; Allopurinol inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased activity of XDH protein]; Allopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]		 CTD PMID:1447108 PMID:3677084 PMID:8891675 PMID:12115777 PMID:12566098 More... NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
alloxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Oxypurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Oxypurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Oxypurinol results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Oxypurinol results in increased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Dek DEK proto-oncogene increases secretion ISO DEK protein results in increased secretion of Oxypurinol CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Oxypurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Oxypurinol results in increased expression of HMOX1 mRNA CTD PMID:25091725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Oxypurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions
increases uptake		 ISO Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] CTD PMID:16135657 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Oxypurinol results in increased expression of TNF mRNA
Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]		 CTD PMID:26641773 PMID:28949055 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Oxypurinol results in decreased activity of XDH protein CTD PMID:26968635 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
aspalathin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:25338943 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G F10 coagulation factor X multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein] CTD PMID:25325928 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII multiple interactions ISO aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein] CTD PMID:25325928 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:25338943 PMID:25655391 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:25655391 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:25655391 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:25655391 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:25655391 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aspalathin inhibits the reaction [Glucose affects the localization of RELA protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:25338943 PMID:25655391 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of SELE protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein] CTD PMID:25338943 PMID:25655391 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO aspalathin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] CTD PMID:25325928 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:25655391 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; aspalathin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] CTD PMID:25325928 PMID:25655391 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of VCAM1 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:25338943 PMID:25655391 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
febuxostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in decreased secretion of AGER protein modified form]; Febuxostat inhibits the reaction [Paraquat results in increased expression of AGER mRNA] CTD PMID:30726711 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:26036690 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:26036690 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] CTD PMID:26036690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Febuxostat results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein] CTD PMID:30726711 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Febuxostat results in increased expression of DUSP10 mRNA CTD PMID:35866629 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Febuxostat results in increased expression of DUSP4 mRNA CTD PMID:35866629 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Febuxostat results in increased expression of DUSP5 mRNA CTD PMID:35866629 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Febuxostat results in increased expression of DUSP8 mRNA CTD PMID:35866629 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Febuxostat results in increased expression of GADD45G mRNA CTD PMID:35866629 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 mRNA]; Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 protein] CTD PMID:29107957 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of HMGB1 mRNA] CTD PMID:30726711 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Febuxostat results in increased expression of IL1RAP mRNA CTD PMID:35866629 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Febuxostat results in increased phosphorylation of MAPK8 protein CTD PMID:35866629 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:30726711 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO Febuxostat results in increased expression of MRAS mRNA CTD PMID:35866629 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:26036690 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Febuxostat results in increased expression of NR4A1 mRNA CTD PMID:35866629 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of PTGS2 mRNA] CTD PMID:30726711 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of RELA protein] CTD PMID:26036690 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Febuxostat inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Febuxostat results in increased expression of TNF mRNA		 CTD PMID:26036690 PMID:26641773 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of VEGFA protein] CTD PMID:30726711 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity ISO Febuxostat results in decreased activity of XDH protein CTD PMID:35866629 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
gemcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Gemcitabine results in increased expression of A2M protein CTD PMID:20531411 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Gemcitabine results in decreased expression of ABCB1 mRNA; Gemcitabine results in decreased expression of ABCB1 protein CTD PMID:35063459 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO Gemcitabine results in decreased expression of ACP3 protein CTD PMID:20531411 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [Gemcitabine results in increased cleavage of AREG protein] CTD PMID:20726858 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Gemcitabine results in increased expression of ADIPOQ protein CTD PMID:20531411 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Gemcitabine results in decreased expression of AFP protein CTD PMID:20531411 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO Gemcitabine results in decreased expression of AGPAT2 mRNA CTD PMID:17039268 NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions		 ISO AKT1 protein affects the susceptibility to Gemcitabine
[Gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with Gemcitabine] results in decreased phosphorylation of AKT1 protein		 CTD PMID:15867245 PMID:29782821 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases expression		 ISO sulforaphane promotes the reaction [Gemcitabine results in decreased expression of ALDH1A1 protein] CTD PMID:20940707 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Gemcitabine results in increased expression of ALDH1A3 mRNA CTD PMID:17039268 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO Gemcitabine results in increased expression of ALDH6A1 mRNA CTD PMID:17039268 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO Gemcitabine results in increased expression of ANAPC1 mRNA CTD PMID:17039268 NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273 		JBrowse link
G Ank3 ankyrin 3 increases expression ISO Gemcitabine results in increased expression of ANK3 mRNA CTD PMID:17039268 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Gemcitabine results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 affects expression ISO Gemcitabine affects the expression of ANTXR1 mRNA CTD PMID:17039268 NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232 		JBrowse link
G Apcs amyloid P component, serum decreases expression ISO Gemcitabine results in decreased expression of APCS protein CTD PMID:20531411 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G Apoh apolipoprotein H increases expression ISO Gemcitabine results in increased expression of APOH protein CTD PMID:20531411 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Ar androgen receptor multiple interactions ISO Gemcitabine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin multiple interactions
decreases response to substance
increases cleavage
increases expression		 ISO ADAM17 protein promotes the reaction [Gemcitabine results in increased cleavage of AREG protein]
AREG protein results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of AREG protein		 CTD PMID:20726858 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases expression ISO Gemcitabine results in decreased expression of ARF1 mRNA CTD PMID:17039268 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO Gemcitabine results in increased expression of ARNT mRNA CTD PMID:20103597 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Gemcitabine results in increased expression of ATF3 mRNA CTD PMID:17039268 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Axin2 axin 2 affects expression ISO Gemcitabine affects the expression of AXIN2 mRNA CTD PMID:20103597 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions ISO AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine] CTD PMID:26206560 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [alvocidib co-treated with Gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with Gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with Gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with Gemcitabine] affects the localization of BAX protein CTD PMID:15770523 PMID:17671697 PMID:20523344 PMID:21570961 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Gemcitabine results in decreased expression of BCL2 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein
[alvocidib co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [Gemcitabine results in decreased expression of BCL2 protein]		 CTD PMID:15476743 PMID:15645133 PMID:15770523 PMID:16929163 PMID:17440100 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
Gemcitabine results in decreased expression of BCL2L1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein		 CTD PMID:15476743 PMID:16929163 PMID:17440100 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Gemcitabine results in increased expression of BCL2L11 mRNA CTD PMID:17039268 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO Gemcitabine results in increased expression of BCL6 mRNA CTD PMID:17039268 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO Gemcitabine results in decreased expression of BDNF protein CTD PMID:20531411 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO Gemcitabine results in increased cleavage of BID protein CTD PMID:14750167 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Gemcitabine results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
affects expression		 ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Gemcitabine affects the expression of BIRC3 mRNA		 CTD PMID:17039268 PMID:17440100 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein
Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]		 CTD PMID:16929163 PMID:17440100 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Gemcitabine results in increased expression of BNIP3L mRNA CTD PMID:17039268 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Gemcitabine results in decreased expression of BRAF mRNA CTD PMID:20103597 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases response to substance
increases expression		 ISO BRCA1 results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of BRCA1 mRNA		 CTD PMID:20103597 PMID:21771338 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
increases activity
multiple interactions		 ISO Gemcitabine results in increased cleavage of CASP3 protein
Gemcitabine results in increased expression of CASP3 protein modified form
Gemcitabine results in increased activity of CASP3 protein
[10-propargyl-10-deazaaminopterin co-treated with Gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with Gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP3 protein; [Gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [Vorinostat co-treated with Gemcitabine] results in increased activity of CASP3 protein; Gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [Gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP3 protein]		 CTD PMID:12479703 PMID:15476743 PMID:15726400 PMID:15770523 PMID:16153448 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP6 protein CTD PMID:20699664 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
increases activity		 ISO Gemcitabine results in increased cleavage of CASP8 protein
[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP8 protein; [Gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with Gemcitabine] results in increased activity of CASP8 protein; Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]
Gemcitabine results in increased activity of CASP8 protein		 CTD PMID:12479703 PMID:14750167 PMID:17159604 PMID:17671697 PMID:18089714 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein
Gemcitabine results in increased activity of CASP9 protein
Gemcitabine results in increased cleavage of CASP9 protein
[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein]		 CTD PMID:12479703 PMID:15476743 PMID:15726400 PMID:17159604 PMID:17440100 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Gemcitabine results in decreased expression of CCL2 protein CTD PMID:20531411 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Gemcitabine results in increased expression of CCL20 mRNA CTD PMID:17039268 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Gemcitabine results in increased expression of CCL3 protein CTD PMID:20531411 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression		 ISO Gemcitabine results in decreased expression of CCNB1 mRNA
Gemcitabine results in increased expression of CCNB1 protein		 CTD PMID:11504793 PMID:20103597 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Gemcitabine results in decreased expression of CCND1 mRNA; Gemcitabine results in decreased expression of CCND1 protein
Celecoxib promotes the reaction [Gemcitabine results in decreased expression of CCND1 protein]		 CTD PMID:16060994 PMID:17039268 PMID:17440100 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Gemcitabine results in increased expression of CCNG2 mRNA CTD PMID:17039268 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein] CTD PMID:32894642 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd40 CD40 molecule decreases expression ISO Gemcitabine results in decreased expression of CD40 mRNA; Gemcitabine results in decreased expression of CD40 protein CTD PMID:17039268 PMID:20531411 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Gemcitabine results in decreased expression of CD40LG protein CTD PMID:20531411 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) affects expression ISO Gemcitabine affects the expression of CD44 mRNA CTD PMID:35063459 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cda cytidine deaminase affects response to substance
multiple interactions		 ISO CDA protein affects the susceptibility to Gemcitabine
[Crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to Gemcitabine; CDA protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [Gemcitabine co-treated with Oxaliplatin]		 CTD PMID:18728667 PMID:22973962 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [Gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein CTD PMID:20103597 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Gemcitabine results in increased expression of CDH1 mRNA CTD PMID:17039268 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Gemcitabine results in increased expression of CDKN1A mRNA; Gemcitabine results in increased expression of CDKN1A protein
[alvocidib co-treated with Gemcitabine] results in increased expression of CDKN1A protein; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]		 CTD PMID:15476743 PMID:15770523 PMID:16601104 PMID:17039268 PMID:25189999 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases response to substance ISO CDKN1B results in decreased susceptibility to Gemcitabine CTD PMID:21652059 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Gemcitabine results in increased expression of CEBPB mRNA CTD PMID:17039268 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:154,343,201...154,370,651
Ensembl chr 1:154,343,201...154,370,640 		JBrowse link
G Ckb creatine kinase B decreases expression ISO Gemcitabine results in decreased expression of CKB mRNA CTD PMID:17039268 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Gemcitabine results in increased expression of CLIC4 mRNA CTD PMID:17039268 NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452 		JBrowse link
G Clu clusterin increases expression
affects response to substance		 ISO Gemcitabine results in increased expression of CLU protein
CLU protein affects the susceptibility to Gemcitabine		 CTD PMID:19007378 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression		 ISO BAY 11-7085 inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression		 ISO BAY 11-7085 inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO Gemcitabine results in decreased expression of COL1A1 protein
Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein]		 CTD PMID:35115509 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Gemcitabine results in decreased expression of CSF2 protein CTD PMID:20531411 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO Gemcitabine results in decreased expression of CSF3 protein CTD PMID:20531411 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO Gemcitabine results in increased expression of CSRP2 mRNA CTD PMID:17039268 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745 		JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO Gemcitabine results in increased expression of CTHRC1 mRNA CTD PMID:17039268 NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Gemcitabine results in increased expression of CTNNB1 mRNA CTD PMID:25605917 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO Gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Gemcitabine results in increased expression of CXCL2 mRNA CTD PMID:17039268 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO Gemcitabine affects the expression of CXCR4 mRNA CTD PMID:20103597 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO Gemcitabine results in decreased expression of CYP24A1 mRNA CTD PMID:17039268 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects expression ISO Gemcitabine affects the expression of DDIT4 mRNA CTD PMID:17039268 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO Gemcitabine results in decreased expression of DHX9 mRNA CTD PMID:17039268 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Gemcitabine results in increased expression of DLG2 mRNA CTD PMID:17039268 NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; [Gemcitabine results in decreased susceptibility to Gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; DNMT1 protein inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine] CTD PMID:25189999 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of DNMT3B protein CTD PMID:25189999 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [TYMP protein co-treated with DPYD protein] affects the susceptibility to Gemcitabine CTD PMID:18728667 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Gemcitabine results in decreased expression of DYNC1H1 mRNA CTD PMID:17039268 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO Gemcitabine results in decreased expression of EDN1 protein CTD PMID:20531411 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 decreases expression ISO Gemcitabine results in decreased expression of EDN2 mRNA CTD PMID:17039268 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression		 ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]
Gemcitabine results in decreased expression of EGF protein		 CTD PMID:20531411 PMID:21613822 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
increases expression
increases phosphorylation
increases degradation		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [Gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; Gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
Gemcitabine results in decreased expression of EGFR mRNA; Gemcitabine results in decreased expression of EGFR protein
Gemcitabine results in increased expression of EGFR mRNA
Gemcitabine results in increased phosphorylation of EGFR protein
Gemcitabine results in increased degradation of EGFR protein		 CTD PMID:17146438 PMID:20103597 PMID:20726858 PMID:21541241 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Gemcitabine results in increased expression of EGR1 mRNA CTD PMID:17039268 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Gemcitabine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO Gemcitabine results in increased expression of ETV1 mRNA CTD PMID:17039268 NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775 		JBrowse link
G Evi2b ecotropic viral integration site 2B decreases expression ISO Gemcitabine results in decreased expression of EVI2B mRNA CTD PMID:17039268 NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560 		JBrowse link
G F7 coagulation factor VII decreases expression ISO Gemcitabine results in decreased expression of F7 protein CTD PMID:20531411 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Gemcitabine results in increased expression of FAS mRNA; Gemcitabine results in increased expression of FAS protein CTD PMID:11138460 PMID:17159604 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbxo25 F-box protein 25 increases expression ISO Gemcitabine results in increased expression of FBXO25 mRNA CTD PMID:17039268 NCBI chr16:75,666,062...75,701,770
Ensembl chr16:75,667,904...75,701,696 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression
multiple interactions		 ISO Gemcitabine results in increased expression of FGF2 protein
[Gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein		 CTD PMID:12738744 PMID:20531411 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO Gemcitabine affects the expression of FGG mRNA CTD PMID:17039268 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Gemcitabine results in decreased expression of FOSL2 mRNA CTD PMID:17039268 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Gemcitabine results in increased expression of FXYD3 mRNA CTD PMID:17039268 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 decreases expression ISO Gemcitabine results in decreased expression of GAL3ST1 mRNA CTD PMID:17039268 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388 		JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO Gemcitabine results in decreased expression of GAS1 mRNA CTD PMID:17039268 NCBI chr17:4,482,168...4,485,153 JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO Gemcitabine results in decreased expression of GASK1B mRNA CTD PMID:17039268 NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 affects response to substance ISO GIPC1 affects the susceptibility to Gemcitabine CTD PMID:25469510 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997 		JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO Gemcitabine affects the expression of GLI2 mRNA CTD PMID:20103597 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Glrx glutaredoxin increases expression ISO Gemcitabine results in increased expression of GLRX mRNA CTD PMID:17039268 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Gpc3 glypican 3 increases expression ISO Gemcitabine results in increased expression of GPC3 mRNA CTD PMID:17039268 NCBI chr  X:131,868,986...132,236,824
Ensembl chr  X:131,868,990...132,236,798 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Gemcitabine results in increased phosphorylation of GSK3B protein CTD PMID:16570353 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 affects expression ISO Gemcitabine affects the expression of GTF2A1 mRNA CTD PMID:17039268 NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Gemcitabine results in increased expression of H2AX protein modified form CTD PMID:20798217 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Gemcitabine results in decreased expression of H4C2 mRNA CTD PMID:17039268 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048 		JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO Gemcitabine results in decreased expression of H4C3 mRNA CTD PMID:17039268
G Hdac9 histone deacetylase 9 increases expression ISO Gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects response to substance ISO HIF1A protein affects the susceptibility to Gemcitabine CTD PMID:16628086 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO CASC9 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]
Gemcitabine results in increased expression of HMOX1 mRNA; Gemcitabine results in increased expression of HMOX1 protein		 CTD PMID:35913601 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hoxb2 homeobox B2 increases expression ISO Gemcitabine results in increased expression of HOXB2 mRNA CTD PMID:17039268 NCBI chr10:81,317,828...81,320,220
Ensembl chr10:81,318,026...81,320,192 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO Gemcitabine results in decreased expression of HSPA1L mRNA CTD PMID:17039268 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Gemcitabine results in increased expression of HSPA5 mRNA CTD PMID:17039268 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 ISO Gemcitabine results in decreased expression of ICAM1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein		 CTD PMID:17440100 PMID:20531411 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma decreases expression ISO Gemcitabine results in decreased expression of IFNG protein CTD PMID:20531411 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO Gemcitabine results in decreased expression of IGF1R mRNA CTD PMID:20103597 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Gemcitabine affects the expression of IGFBP3 mRNA CTD PMID:20103597 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Il10 interleukin 10 decreases expression ISO Gemcitabine results in decreased expression of IL10 protein CTD PMID:20531411 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 increases expression ISO Gemcitabine results in increased expression of IL13 protein CTD PMID:20531411 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il15 interleukin 15 decreases expression ISO Gemcitabine results in decreased expression of IL15 protein CTD PMID:20531411 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il16 interleukin 16 increases expression ISO Gemcitabine results in increased expression of IL16 protein CTD PMID:20531411 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Gemcitabine results in decreased expression of IL1A protein CTD PMID:20531411 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO Gemcitabine results in decreased expression of IL1B protein
[Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein]		 CTD PMID:20531411 PMID:32894642 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Gemcitabine results in decreased expression of IL4 protein CTD PMID:20531411 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
decreases expression		 ISO Gemcitabine results in increased secretion of IL6 protein
Gemcitabine results in increased expression of IL6 mRNA
Gemcitabine results in decreased expression of IL6 protein		 CTD PMID:17039268 PMID:20531411 PMID:28007550 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ilk integrin-linked kinase affects response to substance ISO ILK protein affects the susceptibility to Gemcitabine CTD PMID:15867245 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Ins2 insulin 2 increases expression ISO Gemcitabine results in increased expression of INS protein CTD PMID:20531411 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Gemcitabine results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO Gemcitabine results in increased expression of IQGAP1 mRNA CTD PMID:17039268 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO Gemcitabine results in increased expression of IRAK2 mRNA CTD PMID:17039268 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO Gemcitabine results in decreased expression of IRF3 mRNA CTD PMID:17039268 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to Gemcitabine CTD PMID:20150628 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to Gemcitabine CTD PMID:20150628 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itsn2 intersectin 2 increases expression ISO Gemcitabine results in increased expression of ITSN2 mRNA CTD PMID:17039268 NCBI chr 6:27,616,645...27,727,373
Ensembl chr 6:27,600,406...27,727,124 		JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression ISO Gemcitabine results in decreased expression of JAM3 mRNA CTD PMID:17039268 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:23033007 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Gemcitabine results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282 		JBrowse link
G Kitlg KIT ligand multiple interactions
decreases expression		 ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
Gemcitabine results in decreased expression of KITLG protein		 CTD PMID:20531411 PMID:24979617 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Klf8 KLF transcription factor 8 increases expression ISO Gemcitabine results in increased expression of KLF8 mRNA CTD PMID:17039268 NCBI chr  X:17,950,045...18,132,980
Ensembl chr  X:17,958,843...18,133,182 		JBrowse link
G Krt8 keratin 8 decreases expression ISO Gemcitabine results in decreased expression of KRT8 mRNA CTD PMID:17039268 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Larp4b La ribonucleoprotein 4B increases expression ISO Gemcitabine results in increased expression of LARP4B mRNA CTD PMID:17039268 NCBI chr17:61,138,663...61,217,423
Ensembl chr17:61,138,709...61,187,960 		JBrowse link
G Lep leptin decreases expression ISO Gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO Gemcitabine results in increased expression of LIFR mRNA CTD PMID:17039268 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 decreases expression ISO Gemcitabine results in decreased expression of LPAR6 mRNA CTD PMID:17039268 NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331 		JBrowse link
G Lrrc28 leucine rich repeat containing 28 increases expression ISO Gemcitabine results in increased expression of LRRC28 mRNA CTD PMID:17039268 NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784 		JBrowse link
G Lta lymphotoxin alpha increases expression ISO Gemcitabine results in increased expression of LTA protein CTD PMID:20531411 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO Gemcitabine results in decreased expression of LYZ mRNA CTD PMID:17039268 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO Gemcitabine results in increased expression of MAF mRNA CTD PMID:17039268 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Magea10 MAGE family member A10 decreases expression ISO Gemcitabine results in decreased expression of MAGEA10 mRNA CTD PMID:17039268 NCBI chr  X:150,212,708...150,217,954
Ensembl chr  X:150,213,245...150,214,213 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO Gemcitabine results in increased expression of MAGI1 mRNA CTD PMID:17039268 NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO Gemcitabine results in increased phosphorylation of MAP2K3 protein CTD PMID:15003513 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO Gemcitabine results in increased phosphorylation of MAP2K6 protein CTD PMID:15003513 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Gemcitabine results in increased phosphorylation of MAPK1 protein
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein		 CTD PMID:15476743 PMID:23033007 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein		 CTD PMID:15476743 PMID:23033007 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression
increases phosphorylation		 ISO Gemcitabine results in increased expression of MARCKS mRNA
Gemcitabine results in increased phosphorylation of MARCKS protein		 CTD PMID:9523737 PMID:17039268 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO Gemcitabine results in increased expression of MARS1 mRNA CTD PMID:17039268 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
decreases expression		 ISO Gemcitabine results in increased expression of MDM2 mRNA
Gemcitabine results in decreased expression of MDM2 mRNA		 CTD PMID:17039268 PMID:20103597 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Gemcitabine results in decreased expression of MGMT mRNA CTD PMID:17039268 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir222 microRNA 222 affects response to substance ISO MIR222 mRNA affects the susceptibility to Gemcitabine CTD PMID:35974258 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions ISO MIR24-2 mRNA affects the susceptibility to [Betulinic Acid co-treated with Gemcitabine] CTD PMID:25841339 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein CTD PMID:17440100 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Gemcitabine results in decreased expression of MMP3 protein CTD PMID:20531411 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein		 CTD PMID:12738744 PMID:17440100 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase increases expression ISO Gemcitabine results in increased expression of MPO protein CTD PMID:20531411 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Msln mesothelin multiple interactions EXP Gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form CTD PMID:25347530 NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions
decreases response to substance		 ISO Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to Gemcitabine] CTD PMID:17428446 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO Gemcitabine results in increased expression of MXI1 mRNA CTD PMID:17039268 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO Gemcitabine results in increased expression of MYB mRNA CTD PMID:17039268 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects response to substance		 ISO [Oligonucleotides binds to MYC gene] which results in increased susceptibility to Gemcitabine
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein
MYC affects the susceptibility to Gemcitabine		 CTD PMID:17440100 PMID:23681918 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Gemcitabine results in decreased expression of NANOG mRNA CTD PMID:25605917 PMID:35063459 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 increases expression ISO Gemcitabine results in increased expression of NCBP1 mRNA CTD PMID:17039268 NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Gemcitabine results in increased expression of NEDD9 mRNA CTD PMID:17039268 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Neu1 neuraminidase 1 increases expression ISO Gemcitabine results in increased expression of NEU1 mRNA CTD PMID:17039268 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
increases expression
multiple interactions		 ISO NFE2L2 protein results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of NFE2L2 mRNA; Gemcitabine results in increased expression of NFE2L2 protein
CASC9 protein affects the reaction [Gemcitabine results in increased expression of NFE2L2 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of CASC9 mRNA]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]		 CTD PMID:21489257 PMID:35913601 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 affects expression ISO Gemcitabine affects the expression of NFKB2 mRNA CTD PMID:17039268 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Mastic Resin co-treated with Gemcitabine] results in increased expression of NFKBIA protein CTD PMID:20523344 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbie NFKB inhibitor epsilon affects expression ISO Gemcitabine affects the expression of NFKBIE mRNA CTD PMID:17039268 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Gemcitabine results in increased expression of NNMT mRNA CTD PMID:17039268 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
G Notch1 notch receptor 1 multiple interactions
increases expression		 ISO sulforaphane inhibits the reaction [Gemcitabine results in increased expression of NOTCH1 protein] CTD PMID:20940707 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npepps aminopeptidase puromycin sensitive decreases expression ISO Gemcitabine results in decreased expression of NPEPPS mRNA CTD PMID:17039268 NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967 		JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to Gemcitabine CTD PMID:24736981 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO CASC9 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]
Gemcitabine results in increased expression of NQO1 mRNA; Gemcitabine results in increased expression of NQO1 protein		 CTD PMID:35913601 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO Gemcitabine results in increased expression of NR4A3 mRNA CTD PMID:17039268 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Gemcitabine results in increased expression of NRG1 mRNA CTD PMID:17039268 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 protein results in decreased susceptibility to Gemcitabine CTD PMID:15956974 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression
affects response to substance		 ISO Gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to Gemcitabine		 CTD PMID:16397047 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to Gemcitabine CTD PMID:26378035 NCBI chr 1:209,039,073...209,040,017
Ensembl chr 1:209,037,992...209,045,985 		JBrowse link
G Osm oncostatin M multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pappa pappalysin decreases expression ISO Gemcitabine results in decreased expression of PAPPA protein CTD PMID:20531411 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression ISO Gemcitabine results in increased expression of PAQR8 mRNA CTD PMID:17039268 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Gemcitabine results in increased cleavage of PARP1 protein
[alvocidib co-treated with Gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased cleavage of PARP1 protein]		 CTD PMID:15770523 PMID:17146438 PMID:26894857 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases response to substance ISO PARP2 protein results in decreased susceptibility to Gemcitabine CTD PMID:20798217 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Gemcitabine results in increased expression of PCSK9 mRNA CTD PMID:17039268 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein modified form results in decreased susceptibility to Gemcitabine CTD PMID:16782806 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pdzk1ip1 PDZK1 interacting protein 1 increases expression ISO Gemcitabine results in increased expression of PDZK1IP1 mRNA CTD PMID:17039268 NCBI chr 5:128,618,050...128,623,131
Ensembl chr 5:128,618,237...128,623,131 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] CTD PMID:17440100 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Gemcitabine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression ISO Gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783 		JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Gemcitabine results in increased expression of PLAU mRNA CTD PMID:17039268 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plk1 polo-like kinase 1 decreases expression
multiple interactions
affects response to substance		 ISO Gemcitabine results in decreased expression of PLK1; Gemcitabine results in decreased expression of PLK1 mRNA
[Gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to Gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to Gemcitabine]		 CTD PMID:20103597 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Gemcitabine results in decreased expression of POU5F1 mRNA CTD PMID:35063459 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO Gemcitabine affects the expression of PPARA mRNA CTD PMID:19427843 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects expression ISO Gemcitabine affects the expression of PPARD mRNA CTD PMID:19427843 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Gemcitabine affects the expression of PPARG mRNA CTD PMID:19427843 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO Gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 NCBI chr13:45,753,827...45,802,305
Ensembl chr13:45,753,827...45,802,261 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Gemcitabine results in increased expression of PPP1R15A mRNA CTD PMID:17039268 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Gemcitabine results in increased expression of PSAT1 mRNA CTD PMID:17039268 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Ptch1 patched 1 affects expression ISO Gemcitabine affects the expression of PTCH1 mRNA CTD PMID:20103597 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO Gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Gemcitabine results in decreased expression of PTGS1 mRNA CTD PMID:17039268 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein CTD PMID:17440100 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases response to substance ISO PTK2 protein results in decreased susceptibility to Gemcitabine CTD PMID:14623342 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects expression ISO Gemcitabine affects the expression of PTPN11 mRNA CTD PMID:17039268 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO Gemcitabine results in decreased expression of RAB8A mRNA CTD PMID:17039268 NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678 		JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Gemcitabine CTD PMID:16061639 NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014 		JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO Gemcitabine results in decreased expression of REG3A mRNA CTD PMID:16570353 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO sulforaphane promotes the reaction [Gemcitabine results in decreased expression of REL protein] CTD PMID:20940707 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
increases expression
multiple interactions		 ISO Gemcitabine results in increased phosphorylation of RELA protein
Gemcitabine results in increased expression of RELA protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein
[Gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [Gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [Gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [Gemcitabine results in increased expression of RELA protein]		 CTD PMID:17039268 PMID:17440100 PMID:20523344 PMID:29782821 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Gemcitabine results in increased expression of RGS2 mRNA CTD PMID:17039268 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO Gemcitabine results in increased expression of RNF149 mRNA CTD PMID:17039268 NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279 		JBrowse link
G Rpl37 ribosomal protein L37 increases expression ISO Gemcitabine results in increased expression of RPL37 mRNA CTD PMID:17039268 NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442 		JBrowse link
G Rragd Ras-related GTP binding D increases expression ISO Gemcitabine results in increased expression of RRAGD mRNA CTD PMID:17039268 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 affects response to substance
multiple interactions		 ISO RRM1 protein affects the susceptibility to Gemcitabine
[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 mRNA; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 protein		 CTD PMID:25189999 PMID:26894857 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
affects response to substance		 ISO [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to Gemcitabine		 CTD PMID:25189999 PMID:26894857 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 increases expression ISO Gemcitabine results in increased expression of RSL24D1 mRNA CTD PMID:17039268 NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Gemcitabine results in increased expression of SAT1 mRNA CTD PMID:17039268 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Gemcitabine results in increased expression of SCD mRNA CTD PMID:17039268 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sfn stratifin affects response to substance
multiple interactions
increases methylation
decreases response to substance		 ISO SFN protein affects the susceptibility to Gemcitabine
[DNMT1 protein binds to SFN promoter] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; [Gemcitabine results in decreased susceptibility to Gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in decreased methylation of SFN gene; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of SFN mRNA; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]]; SFN protein inhibits the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]
Gemcitabine results in increased methylation of SFN gene		 CTD PMID:25189999 PMID:26894857 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO Gemcitabine results in decreased expression of SHH mRNA CTD PMID:20103597 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression ISO Gemcitabine results in increased expression of SLC25A29 mRNA CTD PMID:17039268 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940 		JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions EXP
ISO		 Gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
Gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]		 CTD PMID:8713072 PMID:10772724 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 affects response to substance
increases uptake
multiple interactions
decreases response to substance
increases response to substance		 ISO SLC29A1 protein affects the susceptibility to Gemcitabine
SLC29A1 protein results in increased uptake of Gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of Gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of Gemcitabine]
SLC29A1 protein results in decreased susceptibility to Gemcitabine
SLC29A1 mRNA results in increased susceptibility to Gemcitabine; SLC29A1 protein results in increased susceptibility to Gemcitabine		 CTD PMID:15501974 PMID:16868479 PMID:17695509 PMID:18383843 PMID:18452103 More... NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Gemcitabine CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Gemcitabine results in increased expression of SLC2A3 mRNA CTD PMID:17039268 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Gemcitabine results in decreased expression of SLC43A3 mRNA CTD PMID:17039268 NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749 		JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 increases expression ISO Gemcitabine results in increased expression of SLITRK2 mRNA CTD PMID:17039268 NCBI chr  X:145,246,448...145,259,983
Ensembl chr  X:145,246,460...145,271,220 		JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase decreases response to substance
multiple interactions		 ISO SMG1 protein results in decreased susceptibility to Gemcitabine
SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein]		 CTD PMID:21418860 NCBI chr 1:172,441,892...172,543,667
Ensembl chr 1:172,444,936...172,543,698 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO Gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Gemcitabine results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects response to substance
decreases response to substance
multiple interactions		 ISO SRC protein affects the susceptibility to Gemcitabine
SRC protein modified form results in decreased susceptibility to Gemcitabine; SRC protein results in decreased susceptibility to Gemcitabine
[AG 1879 co-treated with SRC] results in increased susceptibility to Gemcitabine		 CTD PMID:15073106 PMID:15194078 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity ISO Gemcitabine results in decreased activity of STAT3 protein CTD PMID:22348037 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO Gemcitabine results in decreased expression of SYNCRIP mRNA CTD PMID:17039268 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515 		JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 decreases expression ISO Gemcitabine results in decreased expression of SZRD1 mRNA CTD PMID:17039268 NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252 		JBrowse link
G Tceal9 transcription elongation factor A like 9 increases expression ISO Gemcitabine results in increased expression of TCEAL9 mRNA CTD PMID:17039268 NCBI chr  X:99,245,645...99,247,720
Ensembl chr  X:99,228,458...99,247,763 		JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 decreases expression ISO Gemcitabine results in decreased expression of TCOF1 mRNA CTD PMID:17039268 NCBI chr18:54,267,015...54,300,324
Ensembl chr18:54,267,026...54,300,324 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases activity		 ISO [Fluorouracil co-treated with Gemcitabine] results in decreased activity of TERT protein
Gemcitabine results in decreased activity of TERT protein		 CTD PMID:16929163 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tfap2a transcription factor AP-2 alpha increases response to substance
multiple interactions		 ISO TFAP2A protein results in increased susceptibility to Gemcitabine
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine		 CTD PMID:21489314 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases response to substance		 ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]] CTD PMID:21613822 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Gemcitabine results in increased expression of TGFB2 mRNA CTD PMID:17039268 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Thpo thrombopoietin increases expression ISO Gemcitabine results in increased expression of THPO protein CTD PMID:20531411 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression		 ISO Gemcitabine results in increased expression of TNF protein
Gemcitabine affects the expression of TNF mRNA		 CTD PMID:17039268 PMID:20531411 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Gemcitabine results in increased expression of TNFAIP3 mRNA CTD PMID:17039268 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Gemcitabine results in increased expression of TNFRSF11B mRNA CTD PMID:17039268 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [TNFSF10 co-treated with Gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with Gemcitabine] results in increased activity of CASP8 protein CTD PMID:17671697 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
affects activity		 ISO Gemcitabine results in increased expression of TP53 protein
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]
Gemcitabine affects the activity of TP53 protein		 CTD PMID:12082016 PMID:16601104 PMID:17671697 PMID:21489314 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Gemcitabine results in increased expression of TP53INP1 mRNA CTD PMID:16570353 PMID:17039268 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Traf1 TNF receptor-associated factor 1 affects expression ISO Gemcitabine affects the expression of TRAF1 mRNA CTD PMID:17039268 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Tube1 tubulin, epsilon 1 increases expression ISO Gemcitabine results in increased expression of TUBE1 mRNA CTD PMID:17039268 NCBI chr20:42,552,390...42,570,324
Ensembl chr20:42,552,437...42,570,314 		JBrowse link
G Tymp thymidine phosphorylase affects response to substance
multiple interactions		 ISO TYMP protein affects the susceptibility to Gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to Gemcitabine; TYMP protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]		 CTD PMID:18728667 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects expression ISO Gemcitabine affects the expression of TYRP1 mRNA CTD PMID:17039268 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Gemcitabine results in decreased expression of UBE2C mRNA CTD PMID:17039268 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO Gemcitabine results in increased expression of UGGT2 mRNA CTD PMID:17039268 NCBI chr15:96,074,557...96,239,365
Ensembl chr15:96,074,564...96,237,806 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 multiple interactions ISO [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; UHRF1 protein inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine] CTD PMID:25189999 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Gemcitabine results in decreased expression of VCAM1 protein CTD PMID:20531411 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 ISO Gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein		 CTD PMID:17039268 PMID:17440100 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO Gemcitabine results in decreased expression of VGF mRNA CTD PMID:17039268 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341 		JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO Gemcitabine results in increased expression of VLDLR mRNA CTD PMID:17039268 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920 		JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO Gemcitabine results in increased expression of VMP1 CTD PMID:20299819 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007 		JBrowse link
G Vwf von Willebrand factor decreases expression ISO Gemcitabine results in decreased expression of VWF protein CTD PMID:20531411 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO Gemcitabine results in decreased expression of WNT5A mRNA CTD PMID:17039268 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; Gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; Gemcitabine promotes the reaction [Rimonabant results in increased expression of XBP1 mRNA] CTD PMID:21525939 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xiap X-linked inhibitor of apoptosis affects response to substance ISO XIAP affects the susceptibility to Gemcitabine CTD PMID:16628085 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
affects response to substance		 ISO SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]]; YAP1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]
YAP1 protein affects the susceptibility to Gemcitabine		 CTD PMID:26894857 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO Gemcitabine results in increased expression of ZNF274 mRNA CTD PMID:17039268 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086 		JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO Gemcitabine results in increased expression of ZNF449 mRNA CTD PMID:17039268 NCBI chr  X:134,120,820...134,140,921
Ensembl chr  X:134,122,636...134,140,924 		JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO Gemcitabine results in decreased expression of ZNF521 mRNA CTD PMID:17039268 NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458 		JBrowse link
hydroxyurea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1b angiotensin II receptor, type 1b increases expression ISO Hydroxyurea results in increased expression of AGTR1B mRNA CTD PMID:27208086 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein] CTD PMID:7577949 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Hydroxyurea results in increased expression of APAF1 mRNA CTD PMID:27208086 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atm ATM serine/threonine kinase increases expression
multiple interactions
increases phosphorylation		 ISO Hydroxyurea results in increased expression of ATM mRNA
Doxorubicin inhibits the reaction [Nocodazole inhibits the reaction [Hydroxyurea results in increased phosphorylation of ATM protein]]; Nocodazole inhibits the reaction [Hydroxyurea results in increased phosphorylation of ATM protein]		 CTD PMID:27208086 PMID:31597699 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 decreases expression ISO Hydroxyurea results in decreased expression of ATP6V0A2 mRNA CTD PMID:34748853 NCBI chr12:31,947,220...31,979,875
Ensembl chr12:31,822,733...32,007,069 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:58,067,666...58,070,628 JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334 PMID:21730979 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Hydroxyurea results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Hydroxyurea results in increased expression of BAX mRNA CTD PMID:16005713 PMID:16356682 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Hydroxyurea results in increased expression of BBC3 mRNA CTD PMID:27208086 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance EXP BCL2L1 gene mutant form results in decreased susceptibility to Hydroxyurea CTD PMID:10970895 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO Hydroxyurea results in increased expression of BIK mRNA CTD PMID:27208086 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Blm BLM RecQ like helicase increases expression
decreases expression		 ISO Hydroxyurea results in increased expression of BLM mRNA
Hydroxyurea results in decreased expression of BLM mRNA		 CTD PMID:18647660 PMID:24211769 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger decreases expression ISO Hydroxyurea results in decreased expression of BMI1 mRNA CTD PMID:12929121 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO Hydroxyurea results in decreased expression of BORA mRNA CTD PMID:17374387 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322 		JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:96,865,634...96,893,506
Ensembl chr13:96,868,580...96,893,503 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Hydroxyurea results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Hydroxyurea results in increased expression of BTG2 mRNA CTD PMID:24211769 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Hydroxyurea results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO [Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein; [Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein; Bucladesine promotes the reaction [Hydroxyurea results in increased activity of CASP3 protein]; Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]; Hydroxyurea promotes the reaction [Valproic Acid results in increased cleavage of CASP3 protein]; NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]		 CTD PMID:10697531 PMID:16005713 PMID:17653085 PMID:23696560 PMID:29228353 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO Hydroxyurea results in increased expression of CASP7 mRNA CTD PMID:27208086 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Hydroxyurea results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO Hydroxyurea results in increased expression of CCNA2 protein CTD PMID:11468187 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression		 ISO Hydroxyurea results in increased expression of CCNB1 protein
Hydroxyurea results in decreased expression of CCNB1 protein		 CTD PMID:11468187 PMID:16356682 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression		 ISO Hydroxyurea results in increased expression of CCND1 protein
Hydroxyurea results in decreased expression of CCND1 protein		 CTD PMID:11468187 PMID:16356682 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Hydroxyurea results in increased expression of CCND2 protein CTD PMID:11468187 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Hydroxyurea results in increased expression of CCND3 protein CTD PMID:11468187 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydroxyurea results in increased expression of CCNE1 protein
Hydroxyurea results in increased expression of CCNE1 mRNA		 CTD PMID:11468187 PMID:27208086 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Hydroxyurea results in decreased expression of CCNE2 mRNA CTD PMID:12929121 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO Hydroxyurea results in increased expression of CCNG1 mRNA CTD PMID:16005713 PMID:27208086 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Hydroxyurea results in increased expression of CCNG2 mRNA CTD PMID:12929121 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Hydroxyurea results in increased expression of CDC25A mRNA CTD PMID:12929121 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Hydroxyurea results in decreased expression of CDCA8 mRNA CTD PMID:17374387 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Hydroxyurea results in decreased expression of CDK4 protein CTD PMID:16356682 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Hydroxyurea results in increased expression of CDK5R1 mRNA CTD PMID:33770205 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:142,838,081...142,872,669
Ensembl chr 3:142,708,028...142,872,677 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO
EXP		 [Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1A mRNA; Hydroxyurea inhibits the reaction [trichostatin A results in increased expression of CDKN1A protein]; Hydroxyurea inhibits the reaction [Valproic Acid results in increased expression of CDKN1A protein]
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]
Hydroxyurea results in increased expression of CDKN1A mRNA; Hydroxyurea results in increased expression of CDKN1A protein		 CTD PMID:10961388 PMID:10978678 PMID:15557822 PMID:16005713 PMID:17653085 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 ISO Hydroxyurea results in increased expression of CDKN1B protein
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA		 CTD PMID:10961388 PMID:17653085 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Hydroxyurea results in increased expression of CDKN1C mRNA CTD PMID:12929121 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression		 ISO Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene]; Hydroxyurea inhibits the reaction [decitabine results in decreased methylation of CDKN2A gene]
Hydroxyurea results in increased expression of CDKN2A protein		 CTD PMID:10961388 PMID:17686055 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Hydroxyurea results in increased expression of CDKN2B mRNA CTD PMID:27208086 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 decreases expression ISO Hydroxyurea results in decreased expression of CEMIP2 mRNA CTD PMID:33770205 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760 		JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression ISO Hydroxyurea results in decreased expression of CHCHD3 mRNA CTD PMID:12929121 NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
increases expression
decreases expression		 ISO Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]
Hydroxyurea results in increased phosphorylation of CHEK1 protein
Hydroxyurea results in increased expression of CHK1 protein modified form
Hydroxyurea results in decreased expression of CHEK1 mRNA		 CTD PMID:12929121 PMID:18158334 PMID:21840268 PMID:32466334 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression
increases phosphorylation		 ISO Hydroxyurea results in increased expression of CHK2 protein modified form
Hydroxyurea results in increased phosphorylation of CHEK2 protein		 CTD PMID:21840268 PMID:32466334 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Hydroxyurea results in decreased expression of CIDEB mRNA CTD PMID:12929121 NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Hydroxyurea results in decreased expression of CKS2 mRNA CTD PMID:17374387 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein decreases expression ISO Hydroxyurea results in decreased expression of CLN8 mRNA CTD PMID:24211769 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774 		JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Hydroxyurea results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199 		JBrowse link
G Col1a2 collagen type I alpha 2 chain affects expression ISO Hydroxyurea affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO Hydroxyurea results in decreased expression of CPB2 mRNA CTD PMID:12929121 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Csta cystatin A affects expression ISO Hydroxyurea affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Hydroxyurea results in increased expression of CYP26A1 mRNA CTD PMID:29990529 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Hydroxyurea results in increased expression of DAPK1 mRNA CTD PMID:27208086 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dclre1c DNA cross-link repair 1C increases response to substance ISO DCLRE1C results in increased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Hydroxyurea results in increased expression of DDB2 mRNA CTD PMID:18647660 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Hydroxyurea results in increased expression of DDIT4L mRNA CTD PMID:27208086 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375 		JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817 		JBrowse link
G Dnmt1 DNA methyltransferase 1 affects response to substance ISO DNMT1 protein affects the susceptibility to Hydroxyurea CTD PMID:17991895 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dym dymeclin increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of E2F1 mRNA CTD PMID:24211769 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Hydroxyurea results in increased expression of E2F8 mRNA CTD PMID:33770205 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Hydroxyurea results in increased expression of EDA2R mRNA CTD PMID:27208086 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Edn3 endothelin 3 decreases expression ISO Hydroxyurea results in decreased expression of EDN3 protein CTD PMID:15020278 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Epo erythropoietin increases expression ISO Hydroxyurea results in increased expression of EPO protein CTD PMID:19724057 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Hydroxyurea results in increased expression of ERCC5 mRNA CTD PMID:12929121 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression ISO Hydroxyurea results in decreased expression of ERRFI1 mRNA CTD PMID:33770205 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Hydroxyurea results in increased expression of EVA1C mRNA CTD PMID:27208086 NCBI chr11:30,089,510...30,163,596
Ensembl chr11:30,089,365...30,163,596 		JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea CTD PMID:25092648 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO Hydroxyurea results in increased expression of FAS mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]		 CTD PMID:16005713 PMID:16356682 PMID:27208086 PMID:29228353 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO Hydroxyurea results in increased expression of FASL mRNA CTD PMID:16356682 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Hydroxyurea results in increased expression of FGF8 mRNA CTD PMID:29990529 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression ISO Hydroxyurea results in increased expression of FKBP3 mRNA CTD PMID:12929121 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Hydroxyurea results in increased expression of and results in increased activity of FOS protein CTD PMID:15772364 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Hydroxyurea results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Hydroxyurea results in increased expression of FOXO1 mRNA CTD PMID:27208086 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Hydroxyurea results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Hydroxyurea results in increased expression of GADD45A mRNA CTD PMID:18647660 PMID:27208086 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects localization
decreases activity
multiple interactions		 ISO Hydroxyurea affects the localization of GAPDH protein
Hydroxyurea results in decreased activity of GAPDH protein
[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea affects the metabolism of and results in decreased activity of and affects the localization of GAPDH protein; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]		 CTD PMID:20889679 PMID:23696560 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Hydroxyurea results in increased expression of GDF15 mRNA CTD PMID:24211769 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease increases expression ISO Hydroxyurea results in increased expression of GEN1 protein CTD PMID:24980922 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein] CTD PMID:20889679 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Hydroxyurea results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Hydroxyurea results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200 		JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
multiple interactions		 ISO Hydroxyurea results in increased expression of H2AX protein; Hydroxyurea results in increased expression of H2AX protein modified form
Hydroxyurea results in increased phosphorylation of H2AX protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]		 CTD PMID:21840268 PMID:25125662 PMID:25130544 PMID:29228353 PMID:32466334 More... NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787 		JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein] CTD PMID:17653085 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,191,852...2,193,957
Ensembl chr16:2,191,852...2,193,957 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Hydroxyurea results in decreased expression of HOXB9 mRNA CTD PMID:29990529 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Hoxc6 homeo box C6 decreases expression ISO Hydroxyurea results in decreased expression of HOXC6 mRNA CTD PMID:29990529 NCBI chr 7:134,138,017...134,148,899
Ensembl chr 7:134,135,502...134,148,392 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Hydroxyurea results in increased expression of HSPA8 mRNA CTD PMID:18647660 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO Hydroxyurea results in increased expression of IER3 mRNA CTD PMID:12929121 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Il13 interleukin 13 affects expression ISO Hydroxyurea affects the expression of IL13 protein CTD PMID:15927844 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Ints15 integrator complex subunit 15 decreases expression ISO Hydroxyurea results in decreased expression of INTS15 mRNA CTD PMID:24211769 NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166 		JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Hydroxyurea results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614 		JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 increases expression ISO Hydroxyurea results in increased expression of ITIH2 mRNA CTD PMID:12929121 NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841 		JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Hydroxyurea results in increased expression of KAT2B mRNA CTD PMID:27208086 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Hydroxyurea results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780 		JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963 		JBrowse link
G Klrb1a killer cell lectin like receptor B1A increases expression ISO Hydroxyurea results in increased expression of KLRB1A mRNA CTD PMID:12929121 NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675 		JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO Hydroxyurea results in decreased expression of KPNA2 mRNA CTD PMID:17374387 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Hydroxyurea results in decreased expression of KRAS mRNA CTD PMID:12929121 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Hydroxyurea results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908 		JBrowse link
G Liph lipase H decreases expression ISO Hydroxyurea results in decreased expression of LIPH mRNA CTD PMID:33770205 NCBI chr11:79,032,229...79,081,625
Ensembl chr11:79,033,312...79,081,625 		JBrowse link
G Lpo lactoperoxidase decreases expression ISO Hydroxyurea results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535 		JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Hydroxyurea results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174 		JBrowse link
G Ltb4r leukotriene B4 receptor increases expression ISO Hydroxyurea results in increased expression of LTB4R1 mRNA CTD PMID:27208086 NCBI chr15:29,263,199...29,265,716 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Hydroxyurea results in decreased expression of MAD2L1 mRNA CTD PMID:12929121 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK1 protein CTD PMID:15557822 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK3 protein CTD PMID:15557822 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK8 protein CTD PMID:15557822 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
affects expression		 ISO Hydroxyurea results in increased expression of MDM2 mRNA
Hydroxyurea affects the expression of MDM2 protein		 CTD PMID:16356682 PMID:18647660 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mecom MDS1 and EVI1 complex locus increases expression ISO Hydroxyurea results in increased expression of MECOM protein mutant form CTD PMID:16532439 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Hydroxyurea results in increased expression of MGMT mRNA CTD PMID:12929121 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:74,755,293...75,090,403
Ensembl chr 6:74,755,395...75,086,811 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression ISO Hydroxyurea results in increased expression of MPG mRNA CTD PMID:12929121 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Hydroxyurea results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616 		JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Hydroxyurea results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Hydroxyurea results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO Hydroxyurea results in decreased expression of MXI1 mRNA CTD PMID:33770205 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Hydroxyurea results in decreased expression of MYB mRNA CTD PMID:12929121 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Myo1e myosin IE decreases expression ISO Hydroxyurea results in decreased expression of MYO1E mRNA CTD PMID:33770205 NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression ISO Hydroxyurea results in decreased expression of NAMPT mRNA CTD PMID:12929121 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nek3 NIMA-related kinase 3 decreases expression ISO Hydroxyurea results in decreased expression of NEK3 mRNA CTD PMID:12929121 NCBI chr16:69,867,020...69,892,477
Ensembl chr16:69,867,047...69,892,508 		JBrowse link
G Neurod4 neuronal differentiation 4 decreases expression ISO Hydroxyurea results in decreased expression of NEUROD4 mRNA CTD PMID:12929121 NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Hydroxyurea results in decreased expression of NFE2L2 mRNA CTD PMID:34748853 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
decreases expression		 ISO Hydroxyurea results in increased expression of NFKB1 mRNA
Hydroxyurea results in decreased expression of NFKB1 mRNA		 CTD PMID:18647660 PMID:34748853 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Hydroxyurea results in increased expression of NFKBIA mRNA CTD PMID:18647660 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO Hydroxyurea results in decreased expression of NOL5 mRNA CTD PMID:12929121 NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810 		JBrowse link
G Notch1 notch receptor 1 multiple interactions
decreases expression		 ISO Doxorubicin inhibits the reaction [Nocodazole promotes the reaction [Hydroxyurea results in decreased expression of NOTCH1 protein]]; Nocodazole promotes the reaction [Hydroxyurea results in decreased expression of NOTCH1 protein]; NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]] CTD PMID:31597699 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nudt12 nudix hydrolase 12 increases expression ISO Hydroxyurea results in increased expression of NUDT12 mRNA CTD PMID:12929121 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO Hydroxyurea results in decreased expression of NUS1 mRNA CTD PMID:12929121 NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Hydroxyurea results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152 		JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 increases expression ISO Hydroxyurea results in increased expression of P2RY6 mRNA CTD PMID:27208086 NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydroxyurea results in increased expression of PCNA mRNA CTD PMID:18647660 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Hydroxyurea results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Hydroxyurea results in increased expression of PERP mRNA CTD PMID:27208086 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Hydroxyurea results in increased expression of PHLDA3 mRNA CTD PMID:24211769 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO Hydroxyurea results in increased expression of PIDD1 mRNA CTD PMID:27208086 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Hydroxyurea results in decreased expression of PKLR mRNA CTD PMID:12929121 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Plk1 polo-like kinase 1 multiple interactions
decreases phosphorylation		 ISO [Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein; Doxorubicin affects the reaction [[Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein]
Hydroxyurea results in decreased phosphorylation of PLK1 protein		 CTD PMID:31597699 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 ISO Hydroxyurea results in increased expression of PMAIP1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]		 CTD PMID:27208086 PMID:29228353 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Hydroxyurea results in increased expression of PML mRNA CTD PMID:27208086 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Polh DNA polymerase eta increases expression ISO Hydroxyurea results in increased expression of POLH mRNA CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Hydroxyurea results in increased expression of PPM1D mRNA CTD PMID:24211769 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression ISO Hydroxyurea results in decreased expression of PPP1R12A mRNA CTD PMID:12929121 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Hydroxyurea results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Hydroxyurea results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prrg4 proline rich and Gla domain 4 increases expression ISO Hydroxyurea results in increased expression of PRRG4 mRNA CTD PMID:27208086 NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273 		JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:182,830,575...182,859,972
Ensembl chr 2:182,830,578...182,859,336 		JBrowse link
G Psip1 PC4 and SRSF1 interacting protein 1 decreases expression ISO Hydroxyurea results in decreased expression of PSIP1 mRNA CTD PMID:12929121 NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257 		JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO Hydroxyurea results in decreased expression of PSRC1 mRNA CTD PMID:17374387 NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874 		JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Hydroxyurea results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714 		JBrowse link
G Rab34 RAB34, member RAS oncogene family increases expression ISO Hydroxyurea results in increased expression of RAB34 mRNA CTD PMID:12929121 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Hydroxyurea results in decreased expression of RAD23A mRNA CTD PMID:12929121 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rad51c RAD51 paralog C increases expression ISO Hydroxyurea results in increased expression of RAD51C mRNA CTD PMID:27825931 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAN mRNA CTD PMID:12929121 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAP2B mRNA CTD PMID:24211769 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069 		JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RARA gene CTD PMID:16868089 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions		 ISO Hydroxyurea results in increased expression of RB1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]		 CTD PMID:27208086 PMID:29228353 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380 		JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Hydroxyurea results in increased expression of RGS16 mRNA CTD PMID:24211769 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Hydroxyurea results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:116,427,941...116,429,164
Ensembl chr  X:116,427,684...116,433,762 		JBrowse link
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase decreases expression ISO Hydroxyurea results in decreased expression of RNF19A mRNA CTD PMID:12929121 NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222 		JBrowse link
G Rnf24 ring finger protein 24 decreases expression ISO Hydroxyurea results in decreased expression of RNF24 mRNA CTD PMID:33770205 NCBI chr 3:118,520,459...118,575,213
Ensembl chr 3:118,525,349...118,541,080 		JBrowse link
G Rnf4 ring finger protein 4 decreases response to substance EXP RNF4 protein results in decreased susceptibility to Hydroxyurea CTD PMID:22661230 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566 		JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO Hydroxyurea results in decreased expression of RPL22L1 mRNA CTD PMID:12929121 NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625 		JBrowse link
G Rras RAS related increases expression ISO Hydroxyurea results in increased expression of RRAS mRNA CTD PMID:12929121 NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases activity ISO Hydroxyurea results in decreased activity of RRM2 protein CTD PMID:22403396 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Hydroxyurea results in increased expression of RRM2B mRNA CTD PMID:18647660 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Hydroxyurea results in increased expression of RUNX1 protein mutant form CTD PMID:16532439 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Hydroxyurea affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sesn1 sestrin 1 increases expression ISO Hydroxyurea results in increased expression of SESN1 mRNA CTD PMID:24211769 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Hydroxyurea results in increased expression of SGK1 mRNA CTD PMID:18647660 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slbp stem-loop histone mRNA binding protein decreases expression ISO Hydroxyurea results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906 		JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) affects transport
increases uptake		 ISO SLC14A1 protein affects the transport of Hydroxyurea
SLC14A1 protein results in increased uptake of Hydroxyurea		 CTD PMID:17506977 PMID:21256917 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 increases uptake ISO SLC14A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968 		JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Hydroxyurea results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 increases uptake ISO SLC22A4 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases uptake ISO SLC22A5 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression ISO Hydroxyurea results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases uptake ISO SLCO1A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake		 ISO naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea] CTD PMID:21256917 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Smim14 small integral membrane protein 14 decreases expression ISO Hydroxyurea results in decreased expression of SMIM14 mRNA CTD PMID:33770205 NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760 		JBrowse link
G Snca synuclein alpha multiple interactions ISO Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron] CTD PMID:14535945 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:56,043,936...56,064,841
Ensembl chr 5:55,981,624...56,064,795 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Hydroxyurea results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stk4 serine/threonine kinase 4 increases cleavage
multiple interactions		 ISO Hydroxyurea results in increased cleavage of STK4 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]		 CTD PMID:29228353 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744 		JBrowse link
G Svop SV2 related protein increases expression ISO Hydroxyurea results in increased expression of SVOP mRNA CTD PMID:27208086 NCBI chr12:42,530,991...42,589,381
Ensembl chr12:42,531,032...42,590,572 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Hydroxyurea results in increased expression of TAP1 mRNA CTD PMID:27208086 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tbpl1 TATA-box binding protein like 1 affects localization ISO Hydroxyurea affects the localization of TBPL1 protein CTD PMID:17085973 NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122 		JBrowse link
G Tbx6 T-box transcription factor 6 decreases expression ISO Hydroxyurea results in decreased expression of TBX6 mRNA CTD PMID:29990529 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593 		JBrowse link
G Tfec transcription factor EC decreases expression ISO Hydroxyurea results in decreased expression of TFEC mRNA CTD PMID:24211769 NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236 		JBrowse link
G Tipin timeless interacting protein decreases expression ISO Hydroxyurea results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Hydroxyurea results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858 		JBrowse link
G Tmem250 transmembrane protein 250 increases expression ISO Hydroxyurea results in increased expression of TMEM250 mRNA CTD PMID:33770205 NCBI chr 3:8,962,657...8,966,349
Ensembl chr 3:8,962,657...8,966,349 		JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO Hydroxyurea results in increased secretion of TNF protein CTD PMID:14965870 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Hydroxyurea results in increased expression of TNFRSF10A mRNA CTD PMID:27208086 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO Hydroxyurea results in decreased expression of TOP1 mRNA CTD PMID:12929121 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Tor1a torsin family 1, member A decreases expression ISO Hydroxyurea results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
affects response to substance
increases expression		 ISO Hydroxyurea results in increased expression of and results in increased phosphorylation of TRP53 protein; Hydroxyurea results in increased phosphorylation of and results in increased activity of and affects the localization of TRP53 protein; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
Hydroxyurea results in increased phosphorylation of TP53 protein
TRP53 affects the susceptibility to Hydroxyurea
Hydroxyurea results in increased expression of TP53 protein; Hydroxyurea results in increased expression of TP53 protein modified form		 CTD PMID:10978678 PMID:16005713 PMID:16356682 PMID:21840268 PMID:25125662 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression
multiple interactions		 ISO Hydroxyurea results in increased expression of TRP53INP1 mRNA; Hydroxyurea results in increased expression of TRP53INP1 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]		 CTD PMID:27208086 PMID:29228353 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Hydroxyurea results in decreased expression of TRP63 mRNA CTD PMID:29228353 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 increases expression
multiple interactions		 ISO Hydroxyurea results in increased expression of TRP73 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]		 CTD PMID:29228353 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Tpp2 tripeptidyl peptidase 2 affects localization ISO Hydroxyurea affects the localization of TPP2 protein CTD PMID:20643100 NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157 		JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in increased expression of TRADD protein] CTD PMID:17653085 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO Hydroxyurea results in increased expression of TRIAP1 mRNA CTD PMID:18647660 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Trim32 tripartite motif-containing 32 decreases expression ISO Hydroxyurea results in decreased expression of TRIM32 mRNA CTD PMID:24211769 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
G Trim38 tripartite motif containing 38 decreases expression ISO Hydroxyurea results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr17:41,351,857...41,365,021 JBrowse link
G Trim68 tripartite motif containing 68 increases expression ISO Hydroxyurea results in increased expression of TRIM68 mRNA CTD PMID:12929121 NCBI chr 1:157,114,044...157,127,494
Ensembl chr 1:157,114,044...157,127,477 		JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:98,960,139...99,107,795
Ensembl chr15:98,960,139...99,107,787 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Hydroxyurea results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Hydroxyurea results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396 		JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO Hydroxyurea results in decreased expression of WNT3A mRNA CTD PMID:29990529 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Hydroxyurea results in increased expression of XPC mRNA CTD PMID:18647660 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808