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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor
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Accession:CHEBI:76744 term browser browse the term
Definition:An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on CH or CH2 (EC 1.17.*.*).
Synonyms:related_synonym: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors;   EC 1.17.* inhibitor;   EC 1.17.* inhibitors;   oxidoreductase acting on CH or CH2 inhibitor;   oxidoreductase acting on CH or CH2 inhibitors


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6-formylpterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist decreases expression ISO 2-amino-4-hydroxy-6-formylpteridine results in decreased expression of BID protein CTD PMID:16019850 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 increases activity ISO 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP3 protein CTD PMID:16019850 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP8 protein CTD PMID:16019850 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 2-amino-4-hydroxy-6-formylpteridine affects the localization of CYCS protein CTD PMID:16019850 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO 2-amino-4-hydroxy-6-formylpteridine affects the localization of PRKCD protein CTD PMID:16019850 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
allopurinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]] CTD PMID:21912612 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] CTD PMID:21912612 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Agt angiotensinogen multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722, PMID:19145780 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Allopurinol results in increased expression of ALDH1A1 mRNA CTD PMID:28138970 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Allopurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Allopurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 protein]
CTD PMID:22426011, PMID:23647015, PMID:24491314 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cat catalase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of CAT protein] CTD PMID:12566098 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO
EXP
Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]
Allopurinol inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]
CTD PMID:15689417, PMID:19158351, PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Cd36 CD36 molecule increases expression EXP Allopurinol results in increased expression of CD36 mRNA CTD PMID:28138970 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein] CTD PMID:22648416 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ckm creatine kinase, M-type decreases secretion EXP Allopurinol results in decreased secretion of CKM protein CTD PMID:21912612 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Allopurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN protein]
CTD PMID:23647015 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in increased expression of FN1 protein] CTD PMID:22648416 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Allopurinol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein] CTD PMID:24491314 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of GSR protein] CTD PMID:12566098 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]
Allopurinol results in increased expression of HMOX1 mRNA
CTD PMID:20888885, PMID:22659318, PMID:25091725 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein] CTD PMID:28949055 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein] CTD PMID:24491314 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:22426011, PMID:23647015 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
Allopurinol results in decreased expression of IL1B mRNA
Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
CTD PMID:7695923, PMID:22426011, PMID:23647015, PMID:24491314 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]
Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
CTD PMID:15689417, PMID:21912612, PMID:22426011, PMID:23867654 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011, PMID:24491314 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Lep leptin multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Allopurinol results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK1 protein]
CTD PMID:26641773 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Allopurinol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] CTD PMID:15650392 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Allopurinol results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK3 protein]
CTD PMID:26641773 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Allopurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:12566098 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Allopurinol inhibits the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]
Allopurinol inhibits the reaction [Oxonic Acid affects the localization of NFAT5 protein]
CTD PMID:23867654, PMID:30651350 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein] CTD PMID:24491314 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]
CTD PMID:22426011, PMID:23647015 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Allopurinol inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]] CTD PMID:21912612 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP
ISO
Allopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein] CTD PMID:23647015 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA protein]
CTD PMID:22426011, PMID:23647015 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO
Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD protein] CTD PMID:22426011, PMID:23647015 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]
CTD PMID:24491314, PMID:28949055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]
CTD PMID:19605544, PMID:21909718, PMID:22865646 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]
CTD PMID:19605544, PMID:21909718, PMID:22865646 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]
CTD PMID:19605544, PMID:21909718, PMID:22865646 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:21909718, PMID:22865646 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]
CTD PMID:21909718, PMID:22426011, PMID:22865646 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]
CTD PMID:19605544, PMID:21909718, PMID:22865646 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport
increases uptake
ISO SLC22A7 protein results in increased transport of Allopurinol
SLC22A7 protein results in increased uptake of Allopurinol
CTD PMID:12065749, PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Allopurinol CTD PMID:15100168 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO Allopurinol inhibits the reaction [Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]] CTD PMID:23867654 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]
CTD PMID:23647015 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]
CTD PMID:23647015 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] CTD PMID:18322232 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]] CTD PMID:21912612 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects activity EXP Allopurinol affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tnf tumor necrosis factor increases chemical synthesis
increases expression
multiple interactions
ISO
EXP
TNF protein results in increased chemical synthesis of Allopurinol
Allopurinol results in increased expression of TNF mRNA
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of TNF mRNA]
Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]
CTD PMID:7695923, PMID:22426011, PMID:26641773, PMID:28949055 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]
CTD PMID:23647015, PMID:24491314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Umod uromodulin multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate affects the expression of UMOD protein]; Allopurinol inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA] CTD PMID:21909718 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Xdh xanthine dehydrogenase decreases activity
multiple interactions
affects activity
ISO
EXP
Allopurinol results in decreased activity of XDH protein
Allopurinol inhibits the reaction [[Streptozocin affects the activity of XDH protein] which results in increased chemical synthesis of Hydrogen Peroxide]; Allopurinol inhibits the reaction [Indomethacin results in increased activity of XDH protein]; Allopurinol inhibits the reaction [Streptozocin affects the activity of XDH protein]; Allopurinol inhibits the reaction [XDH protein results in increased oxidation of Quinoxalines]
Allopurinol affects the activity of XDH protein
Allopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]
CTD PMID:1447108, PMID:3677084, PMID:8891675, PMID:12115777, PMID:12566098, PMID:12694877, PMID:12826072, PMID:14982945, PMID:17439425, PMID:19933411, PMID:20142047, PMID:21939274, PMID:23647015, PMID:26968635 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
alloxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Oxypurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Oxypurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Oxypurinol results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Oxypurinol results in increased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Dek DEK proto-oncogene increases secretion ISO DEK protein results in increased secretion of Oxypurinol CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Oxypurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Oxypurinol results in increased expression of HMOX1 mRNA CTD PMID:25091725 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Oxypurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions
increases uptake
ISO Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] CTD PMID:16135657 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Oxypurinol results in increased expression of TNF mRNA
Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]
CTD PMID:26641773, PMID:28949055 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Oxypurinol results in decreased activity of XDH protein CTD PMID:26968635 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
aspalathin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:25338943 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G F10 coagulation factor X multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein] CTD PMID:25325928 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F5 coagulation factor V multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G F7 coagulation factor VII multiple interactions ISO aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein] CTD PMID:25325928 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:25338943, PMID:25655391 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:25655391 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:25655391 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:25655391 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:25655391 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aspalathin inhibits the reaction [Glucose affects the localization of RELA protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:25338943, PMID:25655391 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sele selectin E multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of SELE protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein] CTD PMID:25338943, PMID:25655391 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO aspalathin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] CTD PMID:25325928 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:25655391 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; aspalathin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] CTD PMID:25325928, PMID:25655391 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of VCAM1 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:25338943, PMID:25655391 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
febuxostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:26036690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:26036690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] CTD PMID:26036690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Febuxostat results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 mRNA]; Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 protein] CTD PMID:29107957 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:26036690 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of RELA protein] CTD PMID:26036690 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
Febuxostat inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Febuxostat results in increased expression of TNF mRNA
CTD PMID:26036690, PMID:26641773 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
gemcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO gemcitabine results in increased expression of A2M protein CTD PMID:20531411 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO gemcitabine results in decreased expression of ACP3 protein CTD PMID:20531411 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein] CTD PMID:20726858 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO gemcitabine results in increased expression of ADIPOQ protein CTD PMID:20531411 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO gemcitabine results in decreased expression of AFP protein CTD PMID:20531411 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO gemcitabine results in decreased expression of AGPAT2 mRNA CTD PMID:17039268 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
ISO AKT1 protein affects the susceptibility to gemcitabine
[gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with gemcitabine] results in decreased phosphorylation of AKT1 protein
CTD PMID:15867245, PMID:29782821 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of ALDH1A1 protein
sulforafan promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein]
CTD PMID:20940707 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO gemcitabine results in increased expression of ALDH1A3 mRNA CTD PMID:17039268 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO gemcitabine results in increased expression of ALDH6A1 mRNA CTD PMID:17039268 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO gemcitabine results in increased expression of ANAPC1 mRNA CTD PMID:17039268 NCBI chr 3:121,147,484...121,226,125
Ensembl chr 3:121,147,547...121,226,125
JBrowse link
G Ank3 ankyrin 3 increases expression ISO gemcitabine results in increased expression of ANK3 mRNA CTD PMID:17039268 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO gemcitabine results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 affects expression ISO gemcitabine affects the expression of ANTXR1 mRNA CTD PMID:17039268 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO gemcitabine results in decreased expression of APCS protein CTD PMID:20531411 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apoh apolipoprotein H increases expression ISO gemcitabine results in increased expression of APOH protein CTD PMID:20531411 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G Ar androgen receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
increases cleavage
decreases response to substance
ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein]
gemcitabine results in increased expression of AREG protein
AREG protein results in decreased susceptibility to gemcitabine
CTD PMID:20726858 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases expression ISO gemcitabine results in decreased expression of ARF1 mRNA CTD PMID:17039268 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO gemcitabine results in increased expression of ARNT mRNA CTD PMID:20103597 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO gemcitabine results in increased expression of ATF3 mRNA CTD PMID:17039268 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Axin2 axin 2 affects expression ISO gemcitabine affects the expression of AXIN2 mRNA CTD PMID:20103597 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions ISO AXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine] CTD PMID:26206560 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [alvocidib co-treated with gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein CTD PMID:15770523, PMID:17671697, PMID:20523344, PMID:21570961 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of BCL2 protein
[alvocidib co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [gemcitabine results in decreased expression of BCL2 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein
CTD PMID:15476743, PMID:15645133, PMID:15770523, PMID:16929163, PMID:17440100, PMID:20523344, PMID:21570961 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
gemcitabine results in decreased expression of BCL2L1 protein
CTD PMID:15476743, PMID:16929163, PMID:17440100 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO gemcitabine results in increased expression of BCL2L11 mRNA CTD PMID:17039268 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO gemcitabine results in increased expression of BCL6 mRNA CTD PMID:17039268 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO gemcitabine results in decreased expression of BDNF protein CTD PMID:20531411 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO gemcitabine results in increased cleavage of BID protein CTD PMID:14750167 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO gemcitabine results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression
multiple interactions
ISO gemcitabine affects the expression of BIRC3 mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
CTD PMID:17039268, PMID:17440100 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16929163, PMID:17440100 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO gemcitabine results in increased expression of BNIP3L mRNA CTD PMID:17039268 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO gemcitabine results in decreased expression of BRAF mRNA CTD PMID:20103597 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression
decreases response to substance
ISO gemcitabine results in increased expression of BRCA1 mRNA
BRCA1 results in decreased susceptibility to gemcitabine
CTD PMID:20103597, PMID:21771338 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
increases cleavage
ISO gemcitabine results in increased activity of CASP3 protein
gemcitabine results in increased expression of CASP3 protein modified form
[10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein
gemcitabine results in increased cleavage of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with gemcitabine] results in increased expression of CASP3 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [vorinostat co-treated with gemcitabine] results in increased activity of CASP3 protein; gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]
CTD PMID:12479703, PMID:15476743, PMID:15726400, PMID:15770523, PMID:16153448, PMID:16467107, PMID:17159604, PMID:17440100, PMID:18089714, PMID:20299819, PMID:20699664, PMID:20798217, PMID:21418860, PMID:26050647, PMID:29782821 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP6 protein CTD PMID:20699664 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP8 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein; gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]
gemcitabine results in increased cleavage of CASP8 protein
gemcitabine results in increased activity of CASP8 protein
CTD PMID:12479703, PMID:14750167, PMID:17159604, PMID:17671697, PMID:18089714, PMID:20699664, PMID:26894857 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein
gemcitabine results in increased cleavage of CASP9 protein
CTD PMID:12479703, PMID:15476743, PMID:15726400, PMID:17159604, PMID:17440100, PMID:20699664, PMID:21418860, PMID:26050647 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO gemcitabine results in decreased expression of CCL2 protein CTD PMID:20531411 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO gemcitabine results in increased expression of CCL20 mRNA CTD PMID:17039268 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CCL3 protein CTD PMID:20531411 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO gemcitabine results in decreased expression of CCNB1 mRNA
gemcitabine results in increased expression of CCNB1 protein
CTD PMID:11504793, PMID:20103597 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [gemcitabine results in decreased expression of CCND1 protein]
gemcitabine results in decreased expression of CCND1 mRNA; gemcitabine results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
CTD PMID:16060994, PMID:17039268, PMID:17440100 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO gemcitabine results in increased expression of CCNG2 mRNA CTD PMID:17039268 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd40 CD40 molecule decreases expression ISO gemcitabine results in decreased expression of CD40 mRNA; gemcitabine results in decreased expression of CD40 protein CTD PMID:17039268, PMID:20531411 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO gemcitabine results in decreased expression of CD40LG protein CTD PMID:20531411 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cda cytidine deaminase affects response to substance
multiple interactions
ISO CDA protein affects the susceptibility to gemcitabine
[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine; CDA protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [gemcitabine co-treated with oxaliplatin]
CTD PMID:18728667, PMID:22973962 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein CTD PMID:20103597 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 increases expression ISO gemcitabine results in increased expression of CDH1 mRNA CTD PMID:17039268 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [alvocidib co-treated with gemcitabine] results in increased expression of CDKN1A protein; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [gemcitabine results in increased expression of CDKN1A protein]
gemcitabine results in increased expression of CDKN1A mRNA; gemcitabine results in increased expression of CDKN1A protein
CTD PMID:15476743, PMID:15770523, PMID:16601104, PMID:17039268, PMID:25189999 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases response to substance ISO CDKN1B results in decreased susceptibility to gemcitabine CTD PMID:21652059 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO gemcitabine results in increased expression of CEBPB mRNA CTD PMID:17039268 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:165,008,997...165,036,431
Ensembl chr 1:165,008,912...165,036,435
JBrowse link
G Ckb creatine kinase B decreases expression ISO gemcitabine results in decreased expression of CKB mRNA CTD PMID:17039268 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO gemcitabine results in increased expression of CLIC4 mRNA CTD PMID:17039268 NCBI chr 5:153,568,937...153,625,669
Ensembl chr 5:153,568,745...153,625,869
JBrowse link
G Clu clusterin affects response to substance
increases expression
ISO CLU protein affects the susceptibility to gemcitabine
gemcitabine results in increased expression of CLU protein
CTD PMID:19007378 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO gemcitabine results in decreased expression of CSF2 protein CTD PMID:20531411 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO gemcitabine results in decreased expression of CSF3 protein CTD PMID:20531411 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO gemcitabine results in increased expression of CSRP2 mRNA CTD PMID:17039268 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO gemcitabine results in increased expression of CTHRC1 mRNA CTD PMID:17039268 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO gemcitabine results in increased expression of CTNNB1 mRNA CTD PMID:25605917 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO gemcitabine results in increased expression of CXCL2 mRNA CTD PMID:17039268 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO gemcitabine affects the expression of CXCR4 mRNA CTD PMID:20103597 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO gemcitabine results in decreased expression of CYP24A1 mRNA CTD PMID:17039268 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects expression ISO gemcitabine affects the expression of DDIT4 mRNA CTD PMID:17039268 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO gemcitabine results in decreased expression of DHX9 mRNA CTD PMID:17039268 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO gemcitabine results in increased expression of DLG2 mRNA CTD PMID:17039268 NCBI chr 1:154,916,274...157,274,077
Ensembl chr 1:156,552,328...157,269,747
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; DNMT1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT3B protein CTD PMID:25189999 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine CTD PMID:18728667 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO gemcitabine results in decreased expression of DYNC1H1 mRNA CTD PMID:17039268 NCBI chr 6:134,958,854...135,085,769
Ensembl chr 6:134,958,854...135,085,769
JBrowse link
G Edn1 endothelin 1 decreases expression ISO gemcitabine results in decreased expression of EDN1 protein CTD PMID:20531411 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 decreases expression ISO gemcitabine results in decreased expression of EDN2 mRNA CTD PMID:17039268 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
gemcitabine results in decreased expression of EGF protein
CTD PMID:20531411, PMID:21613822 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
increases expression
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
gemcitabine results in increased phosphorylation of EGFR protein
gemcitabine results in increased expression of EGFR mRNA
gemcitabine results in decreased expression of EGFR mRNA; gemcitabine results in decreased expression of EGFR protein
gemcitabine results in increased degradation of EGFR protein
CTD PMID:17146438, PMID:20103597, PMID:20726858, PMID:21541241 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression ISO gemcitabine results in increased expression of EGR1 mRNA CTD PMID:17039268 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO gemcitabine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO gemcitabine results in increased expression of ETV1 mRNA CTD PMID:17039268 NCBI chr 6:58,467,215...58,558,640
Ensembl chr 6:58,467,254...58,558,631
JBrowse link
G Evi2b ecotropic viral integration site 2B decreases expression ISO gemcitabine results in decreased expression of EVI2B mRNA CTD PMID:17039268 NCBI chr10:66,856,980...66,858,598
Ensembl chr10:66,856,980...66,858,598
JBrowse link
G F7 coagulation factor VII decreases expression ISO gemcitabine results in decreased expression of F7 protein CTD PMID:20531411 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO gemcitabine results in increased expression of FAS mRNA; gemcitabine results in increased expression of FAS protein CTD PMID:11138460, PMID:17159604 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxo25 F-box protein 25 increases expression ISO gemcitabine results in increased expression of FBXO25 mRNA CTD PMID:17039268 NCBI chr16:80,770,788...80,806,661
Ensembl chr16:80,771,596...80,798,041
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO [gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein
gemcitabine results in increased expression of FGF2 protein
CTD PMID:12738744, PMID:20531411 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO gemcitabine affects the expression of FGG mRNA CTD PMID:17039268 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO gemcitabine results in decreased expression of FOSL2 mRNA CTD PMID:17039268 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO gemcitabine results in increased expression of FXYD3 mRNA CTD PMID:17039268 NCBI chr 1:89,502,561...89,510,146
Ensembl chr 1:89,502,562...89,509,343
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 decreases expression ISO gemcitabine results in decreased expression of GAL3ST1 mRNA CTD PMID:17039268 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO gemcitabine results in decreased expression of GAS1 mRNA CTD PMID:17039268 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO gemcitabine results in decreased expression of GASK1B mRNA CTD PMID:17039268 NCBI chr 2:178,678,946...178,751,459
Ensembl chr 2:178,679,041...178,750,668
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 affects response to substance ISO GIPC1 affects the susceptibility to gemcitabine CTD PMID:25469510 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO gemcitabine affects the expression of GLI2 mRNA CTD PMID:20103597 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Glrx glutaredoxin increases expression ISO gemcitabine results in increased expression of GLRX mRNA CTD PMID:17039268 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpc3 glypican 3 increases expression ISO gemcitabine results in increased expression of GPC3 mRNA CTD PMID:17039268 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO gemcitabine results in increased phosphorylation of GSK3B protein CTD PMID:16570353 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 affects expression ISO gemcitabine affects the expression of GTF2A1 mRNA CTD PMID:17039268 NCBI chr 6:115,321,110...115,352,659
Ensembl chr 6:115,320,467...115,352,681
JBrowse link
G Hdac9 histone deacetylase 9 increases expression ISO gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects response to substance ISO HIF1A protein affects the susceptibility to gemcitabine CTD PMID:16628086 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO gemcitabine results in decreased expression of H4C2 mRNA CTD PMID:17039268 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350
JBrowse link
G Hoxb2 homeobox B2 increases expression ISO gemcitabine results in increased expression of HOXB2 mRNA CTD PMID:17039268 NCBI chr10:84,200,859...84,203,065
Ensembl chr10:84,200,880...84,202,688
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO gemcitabine results in decreased expression of HSPA1L mRNA CTD PMID:17039268 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO gemcitabine results in increased expression of HSPA5 mRNA CTD PMID:17039268 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Curcumin co-treated with gemcitabine] results in decreased expression of ICAM1 protein
gemcitabine results in decreased expression of ICAM1 protein
CTD PMID:17440100, PMID:20531411 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression ISO gemcitabine results in decreased expression of IFNG protein CTD PMID:20531411 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO gemcitabine results in decreased expression of IGF1R mRNA CTD PMID:20103597 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO gemcitabine affects the expression of IGFBP3 mRNA CTD PMID:20103597 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 decreases expression ISO gemcitabine results in decreased expression of IL10 protein CTD PMID:20531411 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases expression ISO gemcitabine results in increased expression of IL13 protein CTD PMID:20531411 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 decreases expression ISO gemcitabine results in decreased expression of IL15 protein CTD PMID:20531411 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il16 interleukin 16 increases expression ISO gemcitabine results in increased expression of IL16 protein CTD PMID:20531411 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO gemcitabine results in decreased expression of IL1A protein CTD PMID:20531411 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO gemcitabine results in decreased expression of IL1B protein CTD PMID:20531411 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 decreases expression ISO gemcitabine results in decreased expression of IL4 protein CTD PMID:20531411 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
increases secretion
increases expression
ISO gemcitabine results in decreased expression of IL6 protein
gemcitabine results in increased secretion of IL6 protein
gemcitabine results in increased expression of IL6 mRNA
CTD PMID:17039268, PMID:20531411, PMID:28007550 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilk integrin-linked kinase affects response to substance ISO ILK protein affects the susceptibility to gemcitabine CTD PMID:15867245 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Ins2 insulin 2 increases expression ISO gemcitabine results in increased expression of INS protein CTD PMID:20531411 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO gemcitabine results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO gemcitabine results in increased expression of IQGAP1 mRNA CTD PMID:17039268 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO gemcitabine results in increased expression of IRAK2 mRNA CTD PMID:17039268 NCBI chr 4:145,594,575...145,651,066
Ensembl chr 4:145,594,575...145,651,053
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO gemcitabine results in decreased expression of IRF3 mRNA CTD PMID:17039268 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itsn2 intersectin 2 increases expression ISO gemcitabine results in increased expression of ITSN2 mRNA CTD PMID:17039268 NCBI chr 6:30,098,378...30,208,694
Ensembl chr 6:30,098,380...30,187,337
JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression ISO gemcitabine results in decreased expression of JAM3 mRNA CTD PMID:17039268 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:23033007 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO gemcitabine results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of KITLG protein
[gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
CTD PMID:20531411, PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klf8 Kruppel-like factor 8 increases expression ISO gemcitabine results in increased expression of KLF8 mRNA CTD PMID:17039268 NCBI chr  X:18,836,902...19,032,012
Ensembl chr  X:18,835,827...18,890,090
JBrowse link
G Krt8 keratin 8 decreases expression ISO gemcitabine results in decreased expression of KRT8 mRNA CTD PMID:17039268 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Larp4b La ribonucleoprotein 4B increases expression ISO gemcitabine results in increased expression of LARP4B mRNA CTD PMID:17039268 NCBI chr17:63,236,007...63,317,298
Ensembl chr17:63,265,407...63,314,019
JBrowse link
G Lep leptin decreases expression ISO gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO gemcitabine results in increased expression of LIFR mRNA CTD PMID:17039268 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G LOC100360841 ribosomal protein L37-like increases expression ISO gemcitabine results in increased expression of RPL37 mRNA CTD PMID:17039268 NCBI chr 9:69,790,829...69,791,199
Ensembl chr 9:69,790,831...69,791,196
JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 decreases expression ISO gemcitabine results in decreased expression of LPAR6 mRNA CTD PMID:17039268 NCBI chr15:55,126,953...55,128,762
Ensembl chr15:55,126,953...55,128,761
JBrowse link
G Lrrc28 leucine rich repeat containing 28 increases expression ISO gemcitabine results in increased expression of LRRC28 mRNA CTD PMID:17039268 NCBI chr 1:128,486,164...128,604,190
Ensembl chr 1:128,486,166...128,604,188
JBrowse link
G Lta lymphotoxin alpha increases expression ISO gemcitabine results in increased expression of LTA protein CTD PMID:20531411 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO gemcitabine results in decreased expression of LYZ mRNA CTD PMID:17039268 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO gemcitabine results in increased expression of MAF mRNA CTD PMID:17039268 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Magea10 MAGE family member A10 decreases expression ISO gemcitabine results in decreased expression of MAGEA10 mRNA CTD PMID:17039268 NCBI chr  X:152,365,785...152,371,961
Ensembl chr  X:152,366,893...152,367,861
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO gemcitabine results in increased expression of MAGI1 mRNA CTD PMID:17039268 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K3 protein CTD PMID:15003513 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K6 protein CTD PMID:15003513 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK1 protein
gemcitabine results in increased phosphorylation of MAPK1 protein
CTD PMID:15476743, PMID:23033007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK3 protein
CTD PMID:15476743, PMID:23033007 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression
increases phosphorylation
ISO gemcitabine results in increased expression of MARCKS mRNA
gemcitabine results in increased phosphorylation of MARCKS protein
CTD PMID:9523737, PMID:17039268 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO gemcitabine results in increased expression of MARS1 mRNA CTD PMID:17039268 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression
increases expression
ISO gemcitabine results in decreased expression of MDM2 mRNA
gemcitabine results in increased expression of MDM2 mRNA
CTD PMID:17039268, PMID:20103597 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO gemcitabine results in decreased expression of MGMT mRNA CTD PMID:17039268 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions ISO MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine] CTD PMID:25841339 NCBI chr19:25,318,863...25,318,970
Ensembl chr19:25,318,863...25,318,970
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MKI67 protein CTD PMID:17440100 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO gemcitabine results in decreased expression of MMP3 protein CTD PMID:20531411 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MMP9 protein
[gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
CTD PMID:12738744, PMID:17440100 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase increases expression ISO gemcitabine results in increased expression of MPO protein CTD PMID:20531411 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msln mesothelin multiple interactions EXP gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form CTD PMID:25347530 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases response to substance
multiple interactions
ISO COX3 protein results in decreased susceptibility to gemcitabine
Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to gemcitabine]
CTD PMID:17428446 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO gemcitabine results in increased expression of MXI1 mRNA CTD PMID:17039268 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO gemcitabine results in increased expression of MYB mRNA CTD PMID:17039268 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
multiple interactions
ISO MYC affects the susceptibility to gemcitabine
[Curcumin co-treated with gemcitabine] results in decreased expression of MYC protein
[Oligonucleotides binds to MYC gene] which results in increased susceptibility to gemcitabine
CTD PMID:17440100, PMID:23681918 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nanog Nanog homeobox decreases expression ISO gemcitabine results in decreased expression of NANOG mRNA CTD PMID:25605917 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 increases expression ISO gemcitabine results in increased expression of NCBP1 mRNA CTD PMID:17039268 NCBI chr 5:61,734,118...61,767,098
Ensembl chr 5:61,734,118...61,766,481
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO gemcitabine results in increased expression of NEDD9 mRNA CTD PMID:17039268 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Neu1 neuraminidase 1 increases expression ISO gemcitabine results in increased expression of NEU1 mRNA CTD PMID:17039268 NCBI chr20:4,610,995...4,615,258
Ensembl chr20:4,610,995...4,615,247
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to gemcitabine CTD PMID:21489257 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 affects expression ISO gemcitabine affects the expression of NFKB2 mRNA CTD PMID:17039268 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Mastic Resin co-treated with gemcitabine] results in increased expression of NFKBIA protein CTD PMID:20523344 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbie NFKB inhibitor epsilon affects expression ISO gemcitabine affects the expression of NFKBIE mRNA CTD PMID:17039268 NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO gemcitabine results in increased expression of NNMT mRNA CTD PMID:17039268 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Notch1 notch receptor 1 increases expression
multiple interactions
ISO gemcitabine results in increased expression of NOTCH1 protein
sulforafan inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein]
CTD PMID:20940707 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Npepps aminopeptidase puromycin sensitive decreases expression ISO gemcitabine results in decreased expression of NPEPPS mRNA CTD PMID:17039268 NCBI chr10:85,140,368...85,222,861
Ensembl chr10:85,140,370...85,222,861
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to gemcitabine CTD PMID:24736981 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO gemcitabine results in increased expression of NR4A3 mRNA CTD PMID:17039268 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO gemcitabine results in increased expression of NRG1 mRNA CTD PMID:17039268 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 protein results in decreased susceptibility to gemcitabine CTD PMID:15956974 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression
affects response to substance
ISO gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to gemcitabine
CTD PMID:16397047 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olr325 olfactory receptor 325 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to gemcitabine CTD PMID:26378035 NCBI chr 1:228,545,913...228,546,857
Ensembl chr 1:228,545,913...228,546,857
JBrowse link
G Osm oncostatin M multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pappa1 pappalysin 1 decreases expression ISO gemcitabine results in decreased expression of PAPPA protein CTD PMID:20531411 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression ISO gemcitabine results in increased expression of PAQR8 mRNA CTD PMID:17039268 NCBI chr 9:27,005,270...27,054,591
Ensembl chr 9:27,034,022...27,051,002
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [alvocidib co-treated with gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein] CTD PMID:15770523, PMID:17146438, PMID:26894857 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases response to substance ISO PARP2 protein results in decreased susceptibility to gemcitabine CTD PMID:20798217 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO gemcitabine results in increased expression of PCSK9 mRNA CTD PMID:17039268 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein modified form results in decreased susceptibility to gemcitabine CTD PMID:16782806 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdzk1ip1 PDZK1 interacting protein 1 increases expression ISO gemcitabine results in increased expression of PDZK1IP1 mRNA CTD PMID:17039268 NCBI chr 5:133,895,849...133,900,720
Ensembl chr 5:133,896,141...133,900,726
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] CTD PMID:17440100 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgr progesterone receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression ISO gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO gemcitabine results in increased expression of PLAU mRNA CTD PMID:17039268 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
affects response to substance
multiple interactions
ISO gemcitabine results in decreased expression of PLK1; gemcitabine results in decreased expression of PLK1 mRNA
PLK1 protein affects the susceptibility to gemcitabine
[gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to gemcitabine]
CTD PMID:20103597 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO gemcitabine affects the expression of PPARA mRNA CTD PMID:19427843 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects expression ISO gemcitabine affects the expression of PPARD mRNA CTD PMID:19427843 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO gemcitabine affects the expression of PPARG mRNA CTD PMID:19427843 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 NCBI chr13:51,134,831...51,183,321
Ensembl chr13:51,134,525...51,183,269
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO gemcitabine results in increased expression of PPP1R15A mRNA CTD PMID:17039268 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO gemcitabine results in increased expression of PSAT1 mRNA CTD PMID:17039268 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Ptch1 patched 1 affects expression ISO gemcitabine affects the expression of PTCH1 mRNA CTD PMID:20103597 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO gemcitabine results in decreased expression of PTGS1 mRNA CTD PMID:17039268 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of PTGS2 protein CTD PMID:17440100 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases response to substance ISO PTK2 protein results in decreased susceptibility to gemcitabine CTD PMID:14623342 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects expression ISO gemcitabine affects the expression of PTPN11 mRNA CTD PMID:17039268 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO gemcitabine results in decreased expression of RAB8A mRNA CTD PMID:17039268 NCBI chr16:19,355,047...19,376,776
Ensembl chr16:19,355,048...19,376,776
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to gemcitabine CTD PMID:16061639 NCBI chr17:70,586,345...70,603,289
Ensembl chr17:70,586,394...70,603,267
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO gemcitabine results in decreased expression of REG3A mRNA CTD PMID:16570353 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO sulforafan promotes the reaction [gemcitabine results in decreased expression of REL protein] CTD PMID:20940707 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
ISO [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [gemcitabine results in increased expression of RELA protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of RELA protein
CTD PMID:17039268, PMID:17440100, PMID:20523344, PMID:29782821 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO gemcitabine results in increased expression of RGS2 mRNA CTD PMID:17039268 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO gemcitabine results in increased expression of RNF149 mRNA CTD PMID:17039268 NCBI chr 9:46,285,546...46,309,692
Ensembl chr 9:46,286,657...46,309,451
JBrowse link
G Rragd Ras-related GTP binding D increases expression ISO gemcitabine results in increased expression of RRAGD mRNA CTD PMID:17039268 NCBI chr 5:48,224,994...48,260,691
Ensembl chr 5:48,224,994...48,260,685
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 multiple interactions
affects response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 protein
RRM1 protein affects the susceptibility to gemcitabine
CTD PMID:25189999, PMID:26894857 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
affects response to substance
decreases response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to gemcitabine
RRM2 protein results in decreased susceptibility to gemcitabine
CTD PMID:14661056, PMID:25189999, PMID:26894857 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 increases expression ISO gemcitabine results in increased expression of RSL24D1 mRNA CTD PMID:17039268 NCBI chr 8:79,792,587...79,801,592
Ensembl chr 8:79,792,587...79,801,594
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO gemcitabine results in increased expression of SAT1 mRNA CTD PMID:17039268 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO gemcitabine results in increased expression of SCD mRNA CTD PMID:17039268 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sfn stratifin multiple interactions
affects response to substance
decreases response to substance
increases methylation
ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased methylation of SFN gene; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
SFN protein affects the susceptibility to gemcitabine
gemcitabine results in increased methylation of SFN gene
CTD PMID:25189999, PMID:26894857 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO gemcitabine results in decreased expression of SHH mRNA CTD PMID:20103597 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression ISO gemcitabine results in increased expression of SLC25A29 mRNA CTD PMID:17039268 NCBI chr 6:132,736,964...132,747,912
Ensembl chr 6:132,735,883...132,747,828
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO
EXP
gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]
gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
CTD PMID:8713072, PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases response to substance
decreases response to substance
increases uptake
affects response to substance
multiple interactions
ISO SLC29A1 mRNA results in increased susceptibility to gemcitabine; SLC29A1 protein results in increased susceptibility to gemcitabine
SLC29A1 protein results in decreased susceptibility to gemcitabine
SLC29A1 protein results in increased uptake of gemcitabine
SLC29A1 protein affects the susceptibility to gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]
CTD PMID:15501974, PMID:16868479, PMID:17695509, PMID:18383843, PMID:18452103, PMID:18490900, PMID:18728667, PMID:18992248, PMID:26894857 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of gemcitabine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO gemcitabine results in increased expression of SLC2A3 mRNA CTD PMID:17039268 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO gemcitabine results in decreased expression of SLC43A3 mRNA CTD PMID:17039268 NCBI chr 3:72,328,912...72,351,039
Ensembl chr 3:72,329,967...72,351,111
JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 increases expression ISO gemcitabine results in increased expression of SLITRK2 mRNA CTD PMID:17039268 NCBI chr  X:151,099,388...151,111,816
Ensembl chr  X:151,103,576...151,107,016
JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase multiple interactions
decreases response to substance
ISO SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
SMG1 protein results in decreased susceptibility to gemcitabine
CTD PMID:21418860 NCBI chr 1:187,781,577...187,882,833
Ensembl chr 1:187,784,270...187,883,157
JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO gemcitabine results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases response to substance
affects response to substance
ISO [AG 1879 co-treated with SRC] results in increased susceptibility to gemcitabine
SRC protein modified form results in decreased susceptibility to gemcitabine; SRC protein results in decreased susceptibility to gemcitabine
SRC protein affects the susceptibility to gemcitabine
CTD PMID:15073106, PMID:15194078 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity ISO gemcitabine results in decreased activity of STAT3 protein CTD PMID:22348037 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO gemcitabine results in decreased expression of SYNCRIP mRNA CTD PMID:17039268 NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342
JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 decreases expression ISO gemcitabine results in decreased expression of SZRD1 mRNA CTD PMID:17039268 NCBI chr 5:159,638,259...159,662,790
Ensembl chr 5:159,638,259...159,662,754
JBrowse link
G Tceal9 transcription elongation factor A like 9 increases expression ISO gemcitabine results in increased expression of TCEAL9 mRNA CTD PMID:17039268 NCBI chr  X:106,791,333...106,794,667
Ensembl chr  X:106,791,333...106,794,657
JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 decreases expression ISO gemcitabine results in decreased expression of TCOF1 mRNA CTD PMID:17039268 NCBI chr18:56,081,863...56,115,719
Ensembl chr18:56,082,195...56,115,593
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases activity
ISO [Fluorouracil co-treated with gemcitabine] results in decreased activity of TERT protein
gemcitabine results in decreased activity of TERT protein
CTD PMID:16929163 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions
increases response to substance
ISO [TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine
TFAP2A protein results in increased susceptibility to gemcitabine
CTD PMID:21489314 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance
multiple interactions
ISO TGFB1 results in decreased susceptibility to gemcitabine
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
CTD PMID:21613822 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO gemcitabine results in increased expression of TGFB2 mRNA CTD PMID:17039268 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thpo thrombopoietin increases expression ISO gemcitabine results in increased expression of THPO protein CTD PMID:20531411 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression
ISO gemcitabine results in increased expression of TNF protein
gemcitabine affects the expression of TNF mRNA
CTD PMID:17039268, PMID:20531411 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO gemcitabine results in increased expression of TNFAIP3 mRNA CTD PMID:17039268 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO gemcitabine results in increased expression of TNFRSF11B mRNA CTD PMID:17039268 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein CTD PMID:17671697 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO gemcitabine results in increased expression of TP53 protein
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine; Nicotine inhibits the reaction [gemcitabine results in increased expression of TP53 protein]
CTD PMID:12082016, PMID:16601104, PMID:17671697, PMID:21489314 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO gemcitabine results in increased expression of TP53INP1 mRNA CTD PMID:16570353, PMID:17039268 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Traf1 TNF receptor-associated factor 1 affects expression ISO gemcitabine affects the expression of TRAF1 mRNA CTD PMID:17039268 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Tube1 tubulin, epsilon 1 increases expression ISO gemcitabine results in increased expression of TUBE1 mRNA CTD PMID:17039268 NCBI chr20:44,220,823...44,238,830
Ensembl chr20:44,220,840...44,238,830
JBrowse link
G Tymp thymidine phosphorylase affects response to substance
multiple interactions
ISO TYMP protein affects the susceptibility to gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine; TYMP protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]
CTD PMID:18728667 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects expression ISO gemcitabine affects the expression of TYRP1 mRNA CTD PMID:17039268 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO gemcitabine results in decreased expression of UBE2C mRNA CTD PMID:17039268 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO gemcitabine results in increased expression of UGGT2 mRNA CTD PMID:17039268 NCBI chr15:104,235,678...104,405,308 JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; UHRF1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO gemcitabine results in decreased expression of VCAM1 protein CTD PMID:20531411 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of VEGFA protein
CTD PMID:17039268, PMID:17440100 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO gemcitabine results in decreased expression of VGF mRNA CTD PMID:17039268 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO gemcitabine results in increased expression of VLDLR mRNA CTD PMID:17039268 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO gemcitabine results in increased expression of VMP1 CTD PMID:20299819 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Vwf von Willebrand factor decreases expression ISO gemcitabine results in decreased expression of VWF protein CTD PMID:20531411 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO gemcitabine results in decreased expression of WNT5A mRNA CTD PMID:17039268 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [rimonabant results in increased expression of XBP1 mRNA] CTD PMID:21525939 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis affects response to substance ISO XIAP affects the susceptibility to gemcitabine CTD PMID:16628085 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
affects response to substance
ISO SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
YAP1 protein affects the susceptibility to gemcitabine
CTD PMID:26894857 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO gemcitabine results in increased expression of ZNF274 mRNA CTD PMID:17039268 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528
JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO gemcitabine results in increased expression of ZNF449 mRNA CTD PMID:17039268 NCBI chr  X:73,390,885...73,413,939
Ensembl chr  X:73,390,903...73,413,931
JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO gemcitabine results in decreased expression of ZNF521 mRNA CTD PMID:17039268 NCBI chr18:5,022,042...5,315,242
Ensembl chr18:5,032,029...5,314,585
JBrowse link
hydroxyurea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1b angiotensin II receptor, type 1b increases expression ISO Hydroxyurea results in increased expression of AGTR1B mRNA CTD PMID:27208086 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein] CTD PMID:7577949 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Hydroxyurea results in increased expression of APAF1 mRNA CTD PMID:27208086 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO Hydroxyurea results in increased expression of ATM mRNA CTD PMID:27208086 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:56,744,563...56,747,657
Ensembl chr 4:56,744,561...56,747,656
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334, PMID:21730979 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Hydroxyurea results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Hydroxyurea results in increased expression of BAX mRNA CTD PMID:16005713, PMID:16356682 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Hydroxyurea results in increased expression of BBC3 mRNA CTD PMID:27208086 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance EXP BCL2L1 gene mutant form results in decreased susceptibility to Hydroxyurea CTD PMID:10970895 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bik BCL2-interacting killer increases expression ISO Hydroxyurea results in increased expression of BIK mRNA CTD PMID:27208086 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Blm BLM RecQ like helicase increases expression
decreases expression
ISO Hydroxyurea results in increased expression of BLM mRNA
Hydroxyurea results in decreased expression of BLM mRNA
CTD PMID:18647660, PMID:24211769 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger decreases expression ISO Hydroxyurea results in decreased expression of BMI1 mRNA CTD PMID:12929121 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO Hydroxyurea results in decreased expression of BORA mRNA CTD PMID:17374387 NCBI chr15:83,442,217...83,463,737
Ensembl chr15:83,442,144...83,463,717
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:103,268,045...103,292,848
Ensembl chr13:103,268,068...103,292,854
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Hydroxyurea results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Hydroxyurea results in increased expression of BTG2 mRNA CTD PMID:24211769 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Hydroxyurea results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO Bucladesine promotes the reaction [Hydroxyurea results in increased activity of CASP3 protein]; Hydroxyurea promotes the reaction [Valproic Acid results in increased cleavage of CASP3 protein]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]
CTD PMID:10697531, PMID:16005713, PMID:17653085, PMID:23696560, PMID:29228353 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases expression ISO Hydroxyurea results in increased expression of CASP7 mRNA CTD PMID:27208086 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Hydroxyurea results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 8:117,812,091...117,830,848
Ensembl chr 8:117,812,099...117,830,868
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Hydroxyurea results in increased expression of CCNA2 protein CTD PMID:11468187 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression
ISO Hydroxyurea results in increased expression of CCNB1 protein
Hydroxyurea results in decreased expression of CCNB1 protein
CTD PMID:11468187, PMID:16356682 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO Hydroxyurea results in increased expression of CCND1 protein
Hydroxyurea results in decreased expression of CCND1 protein
CTD PMID:11468187, PMID:16356682 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Hydroxyurea results in increased expression of CCND2 protein CTD PMID:11468187 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Hydroxyurea results in increased expression of CCND3 protein CTD PMID:11468187 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydroxyurea results in increased expression of CCNE1 protein
Hydroxyurea results in increased expression of CCNE1 mRNA
CTD PMID:11468187, PMID:27208086 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Hydroxyurea results in decreased expression of CCNE2 mRNA CTD PMID:12929121 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng1 cyclin G1 increases expression ISO Hydroxyurea results in increased expression of CCNG1 mRNA CTD PMID:16005713, PMID:27208086 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Hydroxyurea results in increased expression of CCNG2 mRNA CTD PMID:12929121 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Hydroxyurea results in increased expression of CDC25A mRNA CTD PMID:12929121 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Hydroxyurea results in decreased expression of CDCA8 mRNA CTD PMID:17374387 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Hydroxyurea results in decreased expression of CDK4 protein CTD PMID:16356682 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:149,835,953...149,870,429
Ensembl chr 3:149,703,848...149,870,413
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO
EXP
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1A mRNA; Hydroxyurea inhibits the reaction [trichostatin A results in increased expression of CDKN1A protein]; Hydroxyurea inhibits the reaction [Valproic Acid results in increased expression of CDKN1A protein]
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]
Hydroxyurea results in increased expression of CDKN1A mRNA; Hydroxyurea results in increased expression of CDKN1A protein
CTD PMID:10961388, PMID:10978678, PMID:15557822, PMID:16005713, PMID:17653085, PMID:18647660, PMID:21840268, PMID:24211769, PMID:27208086, PMID:29228353 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of CDKN1B protein
[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA
CTD PMID:10961388, PMID:17653085 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Hydroxyurea results in increased expression of CDKN1C mRNA CTD PMID:12929121 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Hydroxyurea inhibits the reaction [Azacitidine results in decreased methylation of CDKN2A gene]; Hydroxyurea inhibits the reaction [decitabine results in decreased methylation of CDKN2A gene]
Hydroxyurea results in increased expression of CDKN2A protein
CTD PMID:10961388, PMID:17686055 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Hydroxyurea results in increased expression of CDKN2B mRNA CTD PMID:27208086 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression ISO Hydroxyurea results in decreased expression of CHCHD3 mRNA CTD PMID:12929121 NCBI chr 4:60,080,536...60,358,592
Ensembl chr 4:60,080,538...60,358,562
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases expression
decreases expression
ISO Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]
Hydroxyurea results in increased expression of CHK1 protein modified form
Hydroxyurea results in decreased expression of CHEK1 mRNA
CTD PMID:12929121, PMID:18158334, PMID:21840268 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Hydroxyurea results in increased expression of CHK2 protein modified form CTD PMID:21840268 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Hydroxyurea results in decreased expression of CIDEB mRNA CTD PMID:12929121 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Hydroxyurea results in decreased expression of CKS2 mRNA CTD PMID:17374387 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein decreases expression ISO Hydroxyurea results in decreased expression of CLN8 mRNA CTD PMID:24211769 NCBI chr16:79,828,321...79,838,212
Ensembl chr16:79,828,324...79,838,212
JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Hydroxyurea results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 5:127,925,726...127,936,516
Ensembl chr 5:127,925,726...127,936,509
JBrowse link
G Col1a2 collagen type I alpha 2 chain affects expression ISO Hydroxyurea affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO Hydroxyurea results in decreased expression of CPB2 mRNA CTD PMID:12929121 NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Csta cystatin A affects expression ISO Hydroxyurea affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Hydroxyurea results in increased expression of CYP26A1 mRNA CTD PMID:29990529 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Hydroxyurea results in increased expression of DAPK1 mRNA CTD PMID:27208086 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dclre1c DNA cross-link repair 1C increases response to substance ISO DCLRE1C results in increased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr17:78,782,512...78,812,140
Ensembl chr17:78,783,437...78,812,111
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Hydroxyurea results in increased expression of DDB2 mRNA CTD PMID:18647660 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Hydroxyurea results in increased expression of DDIT4L mRNA CTD PMID:27208086 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:118,277,046...119,159,807
Ensembl chr 9:118,586,179...119,158,196
JBrowse link
G Dnmt1 DNA methyltransferase 1 affects response to substance ISO DNMT1 protein affects the susceptibility to Hydroxyurea CTD PMID:17991895 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dym dymeclin increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:70,996,074...71,313,033
Ensembl chr18:70,996,044...71,313,084
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of E2F1 mRNA CTD PMID:24211769 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Hydroxyurea results in increased expression of EDA2R mRNA CTD PMID:27208086 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506
JBrowse link
G Edn3 endothelin 3 decreases expression ISO Hydroxyurea results in decreased expression of EDN3 protein CTD PMID:15020278 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Epo erythropoietin increases expression ISO Hydroxyurea results in increased expression of EPO protein CTD PMID:19724057 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Hydroxyurea results in increased expression of ERCC5 mRNA CTD PMID:12929121 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Hydroxyurea results in increased expression of EVA1C mRNA CTD PMID:27208086 NCBI chr11:31,001,697...31,075,784
Ensembl chr11:31,002,451...31,075,809
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea CTD PMID:25092648 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of FAS mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]
CTD PMID:16005713, PMID:16356682, PMID:27208086, PMID:29228353 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO Hydroxyurea results in increased expression of FASL mRNA CTD PMID:16356682 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Hydroxyurea results in increased expression of FGF8 mRNA CTD PMID:29990529 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression ISO Hydroxyurea results in increased expression of FKBP3 mRNA CTD PMID:12929121 NCBI chr 6:86,810,865...86,822,115
Ensembl chr 6:86,810,809...86,822,094
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Hydroxyurea results in increased expression of and results in increased activity of FOS protein CTD PMID:15772364 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Hydroxyurea results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 4:155,653,446...155,679,815
Ensembl chr 4:155,653,718...155,679,793
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Hydroxyurea results in increased expression of FOXO1 mRNA CTD PMID:27208086 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Hydroxyurea results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Hydroxyurea results in increased expression of GADD45A mRNA CTD PMID:18647660, PMID:27208086 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects localization
decreases activity
multiple interactions
ISO Hydroxyurea affects the localization of GAPDH protein
Hydroxyurea results in decreased activity of GAPDH protein
[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea affects the metabolism of and results in decreased activity of and affects the localization of GAPDH protein; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]
CTD PMID:20889679, PMID:23696560 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Hydroxyurea results in increased expression of GDF15 mRNA CTD PMID:24211769 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease increases expression ISO Hydroxyurea results in increased expression of GEN1 protein CTD PMID:24980922 NCBI chr 6:36,910,064...36,940,868
Ensembl chr 6:36,910,675...36,940,868
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein] CTD PMID:20889679 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Hydroxyurea results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr14:79,458,951...79,464,782
Ensembl chr14:79,458,963...79,464,770
JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
multiple interactions
ISO Hydroxyurea results in increased expression of H2AX protein; Hydroxyurea results in increased expression of H2AX protein modified form
Hydroxyurea results in increased phosphorylation of H2AX protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
CTD PMID:25125662, PMID:25130544, PMID:29228353, PMID:32482060 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Hydroxyurea results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein] CTD PMID:17653085 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,616,538...2,636,708
Ensembl chr16:2,634,603...2,636,708
JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Hydroxyurea results in decreased expression of HOXB9 mRNA CTD PMID:29990529 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Hoxc6 homeo box C6 decreases expression ISO Hydroxyurea results in decreased expression of HOXC6 mRNA CTD PMID:29990529 NCBI chr 7:144,612,230...144,626,036
Ensembl chr 7:144,623,555...144,625,516
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Hydroxyurea results in increased expression of HSPA8 mRNA CTD PMID:18647660 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Hydroxyurea results in increased expression of IER3 mRNA CTD PMID:12929121 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Il13 interleukin 13 affects expression ISO Hydroxyurea affects the expression of IL13 protein CTD PMID:15927844 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Hydroxyurea results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 2:187,302,192...187,311,677
Ensembl chr 2:187,302,192...187,311,676
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 increases expression ISO Hydroxyurea results in increased expression of ITIH2 mRNA CTD PMID:12929121 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509
JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Hydroxyurea results in increased expression of KAT2B mRNA CTD PMID:27208086 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Hydroxyurea results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
JBrowse link
G Klrb1a killer cell lectin-like receptor subfamily B, member 1A increases expression ISO Hydroxyurea results in increased expression of KLRB1A mRNA CTD PMID:12929121 NCBI chr 4:161,950,270...161,966,582
Ensembl chr 4:161,949,817...162,025,187
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO Hydroxyurea results in decreased expression of KPNA2 mRNA CTD PMID:17374387 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Hydroxyurea results in decreased expression of KRAS mRNA CTD PMID:12929121 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Hydroxyurea results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 3:22,628,674...22,658,447
Ensembl chr 3:22,640,545...22,658,446
JBrowse link
G LOC102548695 zinc finger protein 45-like decreases expression ISO Hydroxyurea results in decreased expression of ZNF45 mRNA CTD PMID:24211769 NCBI chr 1:81,158,743...81,173,245
Ensembl chr 1:81,159,107...81,163,689
JBrowse link
G LOC683674 similar to Protein C7orf26 homolog decreases expression ISO Hydroxyurea results in decreased expression of C7ORF26 mRNA CTD PMID:24211769 NCBI chr12:13,299,651...13,313,733
Ensembl chr12:13,299,859...13,313,358
JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Hydroxyurea results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 5:171,297,850...171,307,682
Ensembl chr 5:171,297,850...171,307,682
JBrowse link
G Ltb4r leukotriene B4 receptor increases expression ISO Hydroxyurea results in increased expression of LTB4R1 mRNA CTD PMID:27208086 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Hydroxyurea results in decreased expression of MAD2L1 mRNA CTD PMID:12929121 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK1 protein CTD PMID:15557822 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK3 protein CTD PMID:15557822 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP Hydroxyurea results in decreased phosphorylation of MAPK8 protein CTD PMID:15557822 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
affects expression
ISO Hydroxyurea results in increased expression of MDM2 mRNA
Hydroxyurea affects the expression of MDM2 protein
CTD PMID:16356682, PMID:18647660 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mecom MDS1 and EVI1 complex locus increases expression ISO Hydroxyurea results in increased expression of MECOM protein mutant form CTD PMID:16532439 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Hydroxyurea results in increased expression of MGMT mRNA CTD PMID:12929121 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:78,172,842...78,506,232
Ensembl chr 6:78,172,790...78,499,599
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression ISO Hydroxyurea results in increased expression of MPG mRNA CTD PMID:12929121 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Hydroxyurea results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr13:83,805,244...83,842,074
Ensembl chr13:83,805,244...83,842,051
JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Hydroxyurea results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr12:16,398,749...16,403,656
Ensembl chr12:16,398,749...16,403,656
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Hydroxyurea results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Hydroxyurea results in decreased expression of MYB mRNA CTD PMID:12929121 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression ISO Hydroxyurea results in decreased expression of NAMPT mRNA CTD PMID:12929121 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nek3 NIMA-related kinase 3 decreases expression ISO Hydroxyurea results in decreased expression of NEK3 mRNA CTD PMID:12929121 NCBI chr16:74,781,371...74,806,567
Ensembl chr16:74,785,281...74,806,149
JBrowse link
G Neurod4 neuronal differentiation 4 decreases expression ISO Hydroxyurea results in decreased expression of NEUROD4 mRNA CTD PMID:12929121 NCBI chr 7:9,699,964...9,712,067
Ensembl chr 7:9,699,961...9,711,928
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Hydroxyurea results in increased expression of NFKB1 mRNA CTD PMID:18647660 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Hydroxyurea results in increased expression of NFKBIA mRNA CTD PMID:18647660 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO Hydroxyurea results in decreased expression of NOL5 mRNA CTD PMID:12929121 NCBI chr 9:66,495,881...66,520,521
Ensembl chr 9:66,495,832...66,519,788
JBrowse link
G Nudt12 nudix hydrolase 12 increases expression ISO Hydroxyurea results in increased expression of NUDT12 mRNA CTD PMID:12929121 NCBI chr 9:105,680,603...105,693,374
Ensembl chr 9:105,680,670...105,693,357
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO Hydroxyurea results in decreased expression of NUS1 mRNA CTD PMID:12929121 NCBI chr20:33,557,052...33,584,011
Ensembl chr20:33,557,052...33,584,010
JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 increases expression ISO Hydroxyurea results in increased expression of P2RY6 mRNA CTD PMID:27208086 NCBI chr 1:165,972,439...166,008,348
Ensembl chr 1:165,972,440...165,997,751
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydroxyurea results in increased expression of PCNA mRNA CTD PMID:18647660 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Hydroxyurea results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr 2:47,266,758...47,268,526
Ensembl chr 2:47,266,738...47,268,625
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Hydroxyurea results in increased expression of PERP mRNA CTD PMID:27208086 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Hydroxyurea results in increased expression of PHLDA3 mRNA CTD PMID:24211769 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO Hydroxyurea results in increased expression of PIDD1 mRNA CTD PMID:27208086 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Hydroxyurea results in decreased expression of PKLR mRNA CTD PMID:12929121 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of PMAIP1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]
CTD PMID:27208086, PMID:29228353 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Hydroxyurea results in increased expression of PML mRNA CTD PMID:27208086 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Polh DNA polymerase eta increases expression ISO Hydroxyurea results in increased expression of POLH mRNA CTD PMID:25125662 NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Hydroxyurea results in increased expression of PPM1D mRNA CTD PMID:24211769 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression ISO Hydroxyurea results in decreased expression of PPP1R12A mRNA CTD PMID:12929121 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Hydroxyurea results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO Hydroxyurea results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Prrg4 proline rich and Gla domain 4 increases expression ISO Hydroxyurea results in increased expression of PRRG4 mRNA CTD PMID:27208086 NCBI chr 3:94,783,866...94,808,861
Ensembl chr 3:94,784,008...94,808,861
JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:196,427,714...196,457,105
Ensembl chr 2:196,427,710...196,456,481
JBrowse link
G Psip1 PC4 and SFRS1 interacting protein 1 decreases expression ISO Hydroxyurea results in decreased expression of PSIP1 mRNA CTD PMID:12929121 NCBI chr 5:101,555,691...101,588,659
Ensembl chr 5:101,555,694...101,588,598
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO Hydroxyurea results in decreased expression of PSRC1 mRNA CTD PMID:17374387 NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123
JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Hydroxyurea results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 8:36,760,874...36,769,167
Ensembl chr 8:36,766,977...36,769,162
JBrowse link
G Rab34 RAB34, member RAS oncogene family increases expression ISO Hydroxyurea results in increased expression of RAB34 mRNA CTD PMID:12929121 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Hydroxyurea results in decreased expression of RAD23A mRNA CTD PMID:12929121 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rad51c RAD51 paralog C increases expression ISO Hydroxyurea results in increased expression of RAD51C mRNA CTD PMID:27825931 NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAN mRNA CTD PMID:12929121 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family decreases expression ISO Hydroxyurea results in decreased expression of RAP2B mRNA CTD PMID:24211769 NCBI chr 2:151,685,251...151,685,802
Ensembl chr 2:151,685,251...151,685,802
JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RARA gene CTD PMID:16868089 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of RB1 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]
CTD PMID:27208086, PMID:29228353 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:220,038,403...220,049,756
Ensembl chr 1:220,039,734...220,048,966
JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:25,831,358...25,909,976
Ensembl chr 7:25,808,419...25,907,849
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Hydroxyurea results in increased expression of RGS16 mRNA CTD PMID:24211769 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Hydroxyurea results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:123,806,922...123,808,049
Ensembl chr  X:124,516,949...124,518,077
JBrowse link
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase decreases expression ISO Hydroxyurea results in decreased expression of RNF19A mRNA CTD PMID:12929121 NCBI chr 7:75,058,758...75,098,331
Ensembl chr 7:75,058,758...75,098,331
JBrowse link
G Rnf4 ring finger protein 4 decreases response to substance EXP RNF4 protein results in decreased susceptibility to Hydroxyurea CTD PMID:22661230 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO Hydroxyurea results in decreased expression of RPL22L1 mRNA CTD PMID:12929121 NCBI chr 2:115,362,799...115,364,735
Ensembl chr 2:115,362,799...115,364,729
JBrowse link
G Rras RAS related increases expression ISO Hydroxyurea results in increased expression of RRAS mRNA CTD PMID:12929121 NCBI chr 1:101,012,822...101,016,720
Ensembl chr 1:101,012,822...101,016,720
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases activity ISO Hydroxyurea results in decreased activity of RRM2 protein CTD PMID:22403396 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Hydroxyurea results in increased expression of RRM2B mRNA CTD PMID:18647660 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Hydroxyurea results in increased expression of RUNX1 protein mutant form CTD PMID:16532439 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Hydroxyurea affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sesn1 sestrin 1 increases expression ISO Hydroxyurea results in increased expression of SESN1 mRNA CTD PMID:24211769 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Hydroxyurea results in increased expression of SGK1 mRNA CTD PMID:18647660 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slbp stem-loop binding protein decreases expression ISO Hydroxyurea results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr14:82,356,916...82,366,368
Ensembl chr14:82,356,916...82,366,368
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) affects transport
increases uptake
ISO SLC14A1 protein affects the transport of Hydroxyurea
SLC14A1 protein results in increased uptake of Hydroxyurea
CTD PMID:17506977, PMID:21256917 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc14a2 solute carrier family 14 member 2 increases uptake ISO SLC14A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551
JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:252,976,071...253,054,500
Ensembl chr 1:252,976,644...253,000,760
JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Hydroxyurea results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a4 solute carrier family 22 member 4 increases uptake ISO SLC22A4 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases uptake ISO SLC22A5 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases uptake ISO SLCO1A2 protein results in increased uptake of Hydroxyurea CTD PMID:21256917 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake
ISO naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea] CTD PMID:21256917 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Snca synuclein alpha multiple interactions ISO Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron] CTD PMID:14535945 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:57,238,221...57,252,654
Ensembl chr 5:57,239,086...57,250,662
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Hydroxyurea results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stk4 serine/threonine kinase 4 increases cleavage
multiple interactions
ISO Hydroxyurea results in increased cleavage of STK4 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]
CTD PMID:29228353 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Svop SV2 related protein increases expression ISO Hydroxyurea results in increased expression of SVOP mRNA CTD PMID:27208086 NCBI chr12:48,292,272...48,351,974
Ensembl chr12:48,292,273...48,351,084
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Hydroxyurea results in increased expression of TAP1 mRNA CTD PMID:27208086 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tbpl1 TATA-box binding protein like 1 affects localization ISO Hydroxyurea affects the localization of TBPL1 protein CTD PMID:17085973 NCBI chr 1:23,977,154...24,002,512
Ensembl chr 1:23,977,688...24,002,506
JBrowse link
G Tbx6 T-box transcription factor 6 decreases expression ISO Hydroxyurea results in decreased expression of TBX6 mRNA CTD PMID:29990529 NCBI chr 1:198,214,797...198,218,706
Ensembl chr 1:198,214,797...198,218,706
JBrowse link
G Tfec transcription factor EC decreases expression ISO Hydroxyurea results in decreased expression of TFEC mRNA CTD PMID:24211769 NCBI chr 4:44,063,533...44,136,815
Ensembl chr 4:44,065,045...44,136,815
JBrowse link
G Tipin timeless interacting protein decreases expression ISO Hydroxyurea results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 8:69,753,363...69,768,640
Ensembl chr 8:69,753,373...69,768,305
JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Hydroxyurea results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr13:35,554,621...35,557,952
Ensembl chr13:35,554,964...35,556,016
JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:135,394,013...135,397,591
Ensembl chr 5:135,394,016...135,397,591
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO Hydroxyurea results in increased secretion of TNF protein CTD PMID:14965870 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Hydroxyurea results in increased expression of TNFRSF10A mRNA CTD PMID:27208086 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO Hydroxyurea results in decreased expression of TOP1 mRNA CTD PMID:12929121 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Tor1a torsin family 1, member A decreases expression ISO Hydroxyurea results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 3:9,800,322...9,807,318
Ensembl chr 3:9,800,322...9,807,328
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases expression
ISO Hydroxyurea results in increased expression of and results in increased phosphorylation of TRP53 protein; Hydroxyurea results in increased phosphorylation of and results in increased activity of and affects the localization of TRP53 protein; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of CDKN1A mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of RB1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]; TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein]
TRP53 affects the susceptibility to Hydroxyurea
Hydroxyurea results in increased expression of TP53 protein; Hydroxyurea results in increased expression of TP53 protein modified form
CTD PMID:10978678, PMID:16005713, PMID:16356682, PMID:21840268, PMID:25125662, PMID:27208086, PMID:29228353 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of TRP53INP1 mRNA; Hydroxyurea results in increased expression of TRP53INP1 protein
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP53INP1 mRNA]
CTD PMID:27208086, PMID:29228353 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Hydroxyurea results in decreased expression of TRP63 mRNA CTD PMID:29228353 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 increases expression
multiple interactions
ISO Hydroxyurea results in increased expression of TRP73 mRNA
TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of TRP73 mRNA]
CTD PMID:29228353 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tpp2 tripeptidyl peptidase 2 affects localization ISO Hydroxyurea affects the localization of TPP2 protein CTD PMID:20643100 NCBI chr 9:50,664,048...50,744,803
NCBI chr 9:50,578,868...50,628,943
Ensembl chr 9:50,581,234...50,744,803
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO Hydroxyurea promotes the reaction [Valproic Acid results in increased expression of TRADD protein] CTD PMID:17653085 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO Hydroxyurea results in increased expression of TRIAP1 mRNA CTD PMID:18647660 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Trim32 tripartite motif-containing 32 decreases expression ISO Hydroxyurea results in decreased expression of TRIM32 mRNA CTD PMID:24211769 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Trim38 tripartite motif containing 38 decreases expression ISO Hydroxyurea results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr17:43,600,006...43,607,879 JBrowse link
G Trim68 tripartite motif containing 68 increases expression ISO Hydroxyurea results in increased expression of TRIM68 mRNA CTD PMID:12929121 NCBI chr 1:167,835,773...167,849,880
Ensembl chr 1:167,835,647...167,849,834
JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Hydroxyurea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:108,286,407...108,433,531
Ensembl chr15:108,286,453...108,433,529
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Hydroxyurea results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Hydroxyurea results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO Hydroxyurea results in decreased expression of WNT3A mRNA CTD PMID:29990529 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Hydroxyurea results in increased expression of XPC mRNA CTD PMID:18647660 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Hydroxyurea CTD PMID:21785230 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression
increases mutagenesis
ISO Hydroxyurea results in decreased expression of XRCC5 mRNA
Hydroxyurea results in increased mutagenesis of XRCC5 gene
CTD PMID:12929121, PMID:16868089 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Hydroxyurea results in decreased expression of ZBTB24 mRNA CTD PMID:24211769 NCBI chr20:46,168,149...46,189,806
Ensembl chr20:46,168,177...46,189,806
JBrowse link
G Zfp365 zinc finger protein 365 increases expression ISO Hydroxyurea results in increased expression of ZFP365 mRNA CTD PMID:27208086 NCBI chr20:22,060,160...22,083,766
Ensembl chr20:22,060,224...22,086,108
JBrowse link
G Zfp385a zinc finger protein 385A increases expression ISO Hydroxyurea results in increased expression of ZFP385A mRNA CTD PMID:12929121 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370
JBrowse link
G Znf750 zinc finger protein 750 increases expression ISO Hydroxyurea results in increased expression of ZFP750 mRNA CTD PMID:27208086 NCBI chr10:110,698,581...110,701,222
Ensembl chr10:110,698,891...110,701,137
JBrowse link
pedalitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pedalitin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO pedalitin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
purpurogallin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          enzyme inhibitor 18163
            EC 1.* (oxidoreductase) inhibitor 16526
              EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor 525
                EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor + 92
                EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor + 463
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.