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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] |
CTD |
PMID:24161485 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] |
CTD |
PMID:24161485 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] |
CTD |
PMID:24161485 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] |
CTD |
PMID:24161485 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:24161485 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide |
CTD |
PMID:24161485 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone |
CTD |
PMID:24161485 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] |
CTD |
PMID:24161485 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:24161485 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:24161485 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] |
CTD |
PMID:24161485 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions increases activity |
ISO |
baicalein results in increased expression of ABCB1 protein baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] baicalein results in increased activity of ABCB1 protein |
CTD |
PMID:34217736 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
baicalein results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
ISO |
baicalein results in decreased expression of ACTA2 protein baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] |
CTD |
PMID:30201452 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
baicalein binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects response to substance increases expression increases activity |
ISO |
AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; baicalein binds to and results in increased activity of AHR protein AHR protein affects the susceptibility to baicalein baicalein results in increased expression of AHR protein baicalein results in increased activity of AHR protein |
CTD |
PMID:14644660 PMID:17869316 PMID:22820424 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation increases phosphorylation multiple interactions |
ISO |
baicalein results in decreased phosphorylation of AKT1 protein baicalein results in increased phosphorylation of AKT1 protein Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:18025287 PMID:22820424 PMID:36988316 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
multiple interactions decreases activity |
ISO |
baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] baicalein results in decreased activity of ALOX12 protein |
CTD |
PMID:17027136 PMID:23238474 |
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NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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G |
Alox15 |
arachidonate 15-lipoxygenase |
decreases activity |
ISO |
baicalein results in decreased activity of ALOX15 protein |
CTD |
PMID:23238474 |
|
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
App |
amyloid beta precursor protein |
multiple interactions |
EXP |
baicalein inhibits the reaction [APP protein binds to APP protein] |
CTD |
PMID:17323972 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Ascl3 |
achaete-scute family bHLH transcription factor 3 |
affects expression |
ISO |
baicalein affects the expression of ASCL3 protein |
CTD |
PMID:36055377 |
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NCBI chr 1:163,755,306...163,755,951
Ensembl chr 1:163,754,956...163,759,682
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G |
Ascl4 |
achaete-scute family bHLH transcription factor 4 |
affects expression |
ISO |
baicalein affects the expression of ASCL4 protein |
CTD |
PMID:36055377 |
|
NCBI chr 7:17,940,972...17,943,215
Ensembl chr 7:17,941,709...17,942,146
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form] baicalein results in increased expression of BAX protein |
CTD |
PMID:20850421 PMID:21457722 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form] baicalein results in decreased expression of BCL2 protein MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein] |
CTD |
PMID:20850421 PMID:33838155 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
SB 203580 inhibits the reaction [baicalein results in decreased expression of BIRC5 protein]; wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein] |
CTD |
PMID:18025287 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP3 protein modified form] |
CTD |
PMID:20850421 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form] |
CTD |
PMID:20850421 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
baicalein results in decreased expression of CCNA2 protein |
CTD |
PMID:21457722 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
baicalein results in decreased expression of CCNB1 protein |
CTD |
PMID:18025287 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression increases expression |
ISO |
Lithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA] |
CTD |
PMID:19160421 PMID:21457722 PMID:22820424 PMID:24560969 PMID:36988316 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
baicalein results in decreased expression of CCNE1 protein |
CTD |
PMID:24560969 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
baicalein results in decreased phosphorylation of CDK1 protein SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein] |
CTD |
PMID:18025287 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
ISO |
baicalein results in increased expression of CDK4 protein |
CTD |
PMID:22820424 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
baicalein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein] |
CTD |
PMID:34624459 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
baicalein results in decreased expression of CEBPA protein |
CTD |
PMID:24560969 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
decreases expression |
ISO |
baicalein results in decreased expression of CEBPB mRNA |
CTD |
PMID:24560969 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cebpg |
CCAAT/enhancer binding protein gamma |
decreases expression |
ISO |
baicalein results in decreased expression of CEBPG mRNA |
CTD |
PMID:24560969 |
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NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein] |
CTD |
PMID:20850421 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity |
ISO |
baicalein results in increased activity of CFTR protein |
CTD |
PMID:15234961 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:30201452 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
EXP |
baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] |
CTD |
PMID:19474275 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Csf2 |
colony stimulating factor 2 |
decreases expression |
ISO |
baicalein results in decreased expression of CSF2 mRNA |
CTD |
PMID:10718847 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of CYCS protein] |
CTD |
PMID:20850421 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression decreases expression multiple interactions increases chemical synthesis decreases activity |
ISO |
baicalein results in increased expression of CYP1A1 protein baicalein results in decreased expression of CYP1A1 mRNA [CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CYP1A1 protein results in increased chemical synthesis of baicalein baicalein results in decreased activity of CYP1A1 protein |
CTD |
PMID:12224597 PMID:14644660 PMID:18451504 PMID:19666078 PMID:21053930 PMID:21482471 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases chemical synthesis multiple interactions |
ISO |
baicalein results in decreased activity of CYP1A2 protein CYP1A2 protein results in increased chemical synthesis of baicalein [CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein |
CTD |
PMID:19666078 PMID:21053930 PMID:29753067 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity increases chemical synthesis multiple interactions |
ISO |
baicalein results in decreased activity of CYP1B1 protein CYP1B1 protein results in increased chemical synthesis of baicalein [CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein binds to and results in decreased activity of CYP1B1 protein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:12224597 PMID:19666078 PMID:21053930 PMID:21482471 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
baicalein results in increased expression of CYP2B6 mRNA |
CTD |
PMID:25625231 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions decreases activity |
ISO |
baicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] baicalein results in decreased activity of CYP2C9 protein |
CTD |
PMID:21053930 PMID:29753067 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
baicalein results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
baicalein results in decreased activity of CYP2E1 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
baicalein results in decreased activity of CYP3A4 protein |
CTD |
PMID:21053930 PMID:29753067 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
decreases expression |
ISO |
baicalein results in decreased expression of DGAT1 protein |
CTD |
PMID:24560969 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
increases expression |
ISO |
baicalein results in increased expression of DLK1 mRNA |
CTD |
PMID:24560969 |
|
NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:25625231 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases phosphorylation |
ISO |
baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of EGFR protein] |
CTD |
PMID:25625231 PMID:33838155 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr2 |
early growth response 2 |
decreases expression |
ISO |
baicalein results in decreased expression of EGR2 mRNA |
CTD |
PMID:24560969 |
|
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions |
ISO |
baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:25625231 |
|
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions decreases expression |
ISO |
baicalein results in decreased expression of and results in decreased phosphorylation of ERBB2 protein baicalein results in decreased expression of ERBB2 mRNA |
CTD |
PMID:36988316 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
baicalein results in decreased expression of FABP4 protein |
CTD |
PMID:24560969 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
baicalein results in decreased expression of FASN protein |
CTD |
PMID:24560969 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] |
CTD |
PMID:30201452 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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|
G |
Glb1 |
galactosidase, beta 1 |
multiple interactions |
ISO |
baicalein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein] |
CTD |
PMID:34624459 |
|
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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|
G |
Gli1 |
GLI family zinc finger 1 |
decreases expression |
ISO |
baicalein results in decreased expression of GLI1 mRNA; baicalein results in decreased expression of GLI1 protein |
CTD |
PMID:20395211 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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|
G |
Gpat3 |
glycerol-3-phosphate acyltransferase 3 |
decreases expression |
ISO |
baicalein results in decreased expression of GPAT3 protein |
CTD |
PMID:24560969 |
|
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
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|
G |
Gpx4 |
glutathione peroxidase 4 |
affects expression |
ISO |
baicalein affects the expression of GPX4 protein |
CTD |
PMID:36055377 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation multiple interactions |
ISO |
baicalein results in decreased phosphorylation of GSK3B protein baicalein inhibits the reaction [Mitomycin results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:22820424 PMID:34624459 PMID:36988316 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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|
G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions increases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA] |
CTD |
PMID:19160421 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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|
G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
multiple interactions increases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA] |
CTD |
PMID:19160421 |
|
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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|
G |
Hey2 |
hes-related family bHLH transcription factor with YRPW motif 2 |
multiple interactions increases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA] |
CTD |
PMID:19160421 |
|
NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
baicalein results in increased expression of HMOX1 mRNA; baicalein results in increased expression of HMOX1 protein Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]] |
CTD |
PMID:14563492 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
multiple interactions increases activity |
ISO |
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein] |
CTD |
PMID:18032417 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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|
G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] |
CTD |
PMID:17458902 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein] |
CTD |
PMID:22369883 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Ins2 |
insulin 2 |
multiple interactions increases secretion |
ISO |
baicalein promotes the reaction [Glucose results in increased secretion of INS protein] baicalein results in increased secretion of INS protein |
CTD |
PMID:17192482 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] |
CTD |
PMID:17458902 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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|
G |
Klf2 |
KLF transcription factor 2 |
increases expression |
ISO |
baicalein results in increased expression of KLF2 mRNA |
CTD |
PMID:24560969 |
|
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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|
G |
Klf5 |
KLF transcription factor 5 |
decreases expression |
ISO |
baicalein results in decreased expression of KLF5 mRNA |
CTD |
PMID:24560969 |
|
NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
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|
G |
Lpin1 |
lipin 1 |
decreases expression |
ISO |
baicalein results in decreased expression of LPIN1 protein |
CTD |
PMID:24560969 |
|
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein] baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK1 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
baicalein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK3 protein] baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK3 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
baicalein results in decreased phosphorylation of and results in decreased activity of MAPK8 protein |
CTD |
PMID:10718847 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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|
G |
Mir1224 |
microRNA 1224 |
increases expression |
ISO |
baicalein results in increased expression of MIR1224 mRNA |
CTD |
PMID:33838155 |
|
NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986
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|
G |
Mir21 |
microRNA 21 |
multiple interactions |
ISO |
baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] |
CTD |
PMID:30201452 |
|
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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|
G |
Mir322 |
microRNA 322 |
increases expression |
ISO |
baicalein results in increased expression of MIR424 mRNA |
CTD |
PMID:33838155 |
|
NCBI chr X:132,806,594...132,806,688
Ensembl chr X:132,806,594...132,806,688
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|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases activity multiple interactions |
ISO |
baicalein results in decreased activity of MMP2 protein baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA] |
CTD |
PMID:21803068 PMID:22369883 PMID:36988316 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases activity |
ISO |
baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein] baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA] baicalein results in decreased activity of MMP9 protein |
CTD |
PMID:19804834 PMID:21803068 PMID:22369883 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein] |
CTD |
PMID:27780710 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
baicalein results in decreased phosphorylation of and results in decreased activity of MTOR protein |
CTD |
PMID:24560969 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G |
Nat1 |
N-acetyltransferase 1 |
decreases expression |
ISO |
baicalein results in decreased expression of NAT1 mRNA; baicalein results in decreased expression of NAT1 protein |
CTD |
PMID:15796204 |
|
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases localization |
ISO |
baicalein results in decreased localization of NFKB1 protein |
CTD |
PMID:21803068 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases phosphorylation |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of NFKBIA protein] baicalein results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:20850421 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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|
G |
Nfkbib |
NFKB inhibitor beta |
decreases phosphorylation |
ISO |
baicalein results in decreased phosphorylation of NFKBIB protein |
CTD |
PMID:21803068 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO |
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; tin protoporphyrin IX inhibits the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]] baicalein results in decreased expression of NOS2 protein |
CTD |
PMID:14563492 PMID:20850421 PMID:22369883 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Notch1 |
notch receptor 1 |
increases activity increases expression |
ISO |
baicalein results in increased activity of NOTCH1 protein baicalein results in increased expression of NOTCH1 mRNA |
CTD |
PMID:19160421 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects localization |
ISO |
baicalein affects the localization of NR1I3 protein |
CTD |
PMID:25625231 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Pkm |
pyruvate kinase M1/2 |
increases activity |
ISO |
baicalein results in increased activity of PKM protein |
CTD |
PMID:25388478 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pla2g2a |
phospholipase A2 group IIA |
multiple interactions |
ISO |
baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:31811862 |
|
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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|
G |
Plau |
plasminogen activator, urokinase |
decreases activity |
ISO |
baicalein results in decreased activity of PLAU protein |
CTD |
PMID:21803068 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
|
|
G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
multiple interactions |
ISO |
baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] |
CTD |
PMID:17216584 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
baicalein results in decreased expression of PPARG protein |
CTD |
PMID:24560969 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkca |
protein kinase C, alpha |
decreases phosphorylation |
ISO |
baicalein results in decreased phosphorylation of PRKCA protein |
CTD |
PMID:21803068 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein] |
CTD |
PMID:19804834 PMID:22369883 PMID:31811862 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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|
G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions decreases phosphorylation |
ISO |
AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein] |
CTD |
PMID:22820424 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases phosphorylation affects localization decreases localization |
ISO |
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of RELA protein]; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] baicalein results in decreased phosphorylation of RELA protein MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]; NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein] baicalein results in decreased localization of RELA protein |
CTD |
PMID:20850421 PMID:21803068 PMID:22369883 PMID:29481769 PMID:33838155 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
ISO |
baicalein results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein |
CTD |
PMID:24560969 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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|
G |
Sh3gl1 |
SH3 domain containing GRB2 like 1, endophilin A2 |
decreases expression multiple interactions |
ISO |
baicalein results in decreased expression of SH3GL1 mRNA; baicalein results in decreased expression of SH3GL1 protein MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of SH3GL1 protein] |
CTD |
PMID:33838155 |
|
NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
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|
G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity |
ISO |
baicalein results in decreased activity of SLC22A6 protein |
CTD |
PMID:32159797 |
|
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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|
G |
Snca |
synuclein alpha |
multiple interactions |
ISO |
baicalein inhibits the reaction [SNCA protein binds to SNCA protein] baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:27425033 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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|
G |
Spry1 |
sprouty RTK signaling antagonist 1 |
multiple interactions |
ISO |
baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] |
CTD |
PMID:30201452 |
|
NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189
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|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
decreases expression |
ISO |
baicalein results in decreased expression of SREBF1 protein |
CTD |
PMID:24560969 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:30201452 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] |
CTD |
PMID:19474275 PMID:30201452 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] |
CTD |
PMID:27425033 |
|
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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|
G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions |
ISO |
baicalein results in decreased expression of TNF protein baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein] |
CTD |
PMID:20850421 PMID:22369883 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
baicalein results in increased expression of TP53 protein |
CTD |
PMID:21457722 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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|
G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
baicalein results in decreased expression of VEGFA protein |
CTD |
PMID:16638750 PMID:36988316 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein] |
CTD |
PMID:34044073 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein] |
CTD |
PMID:20850421 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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|
|
G |
Ache |
acetylcholinesterase |
multiple interactions increases expression |
EXP |
baicalin results in increased expression of and results in increased activity of ACHE protein baicalin results in increased expression of ACHE mRNA |
CTD |
PMID:27019979 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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|
G |
Ahr |
aryl hydrocarbon receptor |
increases activity |
ISO |
baicalin results in increased activity of AHR protein |
CTD |
PMID:17869316 PMID:26204831 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
EXP |
baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein] |
CTD |
PMID:20139896 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Angpt1 |
angiopoietin 1 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in decreased expression of ANGPT1 mRNA] |
CTD |
PMID:34414639 |
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NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:24312512 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
baicalin results in increased expression of BAX protein baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein] baicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein] baicalin inhibits the reaction [Rotenone affects the expression of BAX protein] |
CTD |
PMID:21457722 PMID:25423838 PMID:31021006 PMID:36446982 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein] baicalin results in decreased expression of BCL2 protein baicalin affects the reaction [Rotenone results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein] |
CTD |
PMID:25423838 PMID:31021006 PMID:36446982 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein] baicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein] baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein] |
CTD |
PMID:25423838 PMID:31021006 PMID:36446982 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
baicalin results in decreased expression of CCNA2 protein |
CTD |
PMID:21457722 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
increases expression decreases expression multiple interactions |
ISO |
baicalin results in increased expression of CCND1 mRNA baicalin results in decreased expression of CCND1 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA] |
CTD |
PMID:19160421 PMID:21457722 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
EXP |
baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] |
CTD |
PMID:19474275 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein |
CTD |
PMID:18451504 PMID:26204831 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression |
ISO |
3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein] resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein] baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein |
CTD |
PMID:26204831 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:25625231 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:25625231 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions |
ISO |
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:25625231 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:29031535 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Foxa2 |
forkhead box A2 |
decreases expression |
ISO |
baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein |
CTD |
PMID:32687838 |
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NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein] |
CTD |
PMID:15645217 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] |
CTD |
PMID:15645217 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hes1 |
hes family bHLH transcription factor 1 |
increases expression multiple interactions |
ISO |
baicalin results in increased expression of HES1 mRNA N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA] |
CTD |
PMID:19160421 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
increases expression multiple interactions |
ISO |
baicalin results in increased expression of HEY1 mRNA N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA] |
CTD |
PMID:19160421 |
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NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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G |
Hey2 |
hes-related family bHLH transcription factor with YRPW motif 2 |
multiple interactions increases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA] |
CTD |
PMID:19160421 |
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NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein] baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein |
CTD |
PMID:16824337 PMID:18187930 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf1a |
HNF1 homeobox A |
multiple interactions decreases expression |
ISO |
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein] baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein |
CTD |
PMID:32687838 |
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NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
decreases expression multiple interactions |
ISO |
baicalin results in decreased expression of HNF4A protein baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens] baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein |
CTD |
PMID:32687838 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein] |
CTD |
PMID:34414639 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein] baicalin inhibits the reaction [Rotenone results in increased expression of IL1B protein] |
CTD |
PMID:29031535 PMID:36446982 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
decreases expression multiple interactions |
EXP ISO |
baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein] |
CTD |
PMID:22019745 PMID:29031535 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] |
CTD |
PMID:34414639 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:34414639 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:34414639 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
decreases expression |
EXP |
baicalin results in decreased expression of MYD88 protein |
CTD |
PMID:22019745 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression |
EXP |
baicalin results in increased expression of NFKBIA protein |
CTD |
PMID:22019745 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] |
CTD |
PMID:29031535 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
EXP ISO |
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein] |
CTD |
PMID:18187930 PMID:22019745 PMID:24312512 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Notch1 |
notch receptor 1 |
increases activity increases expression |
ISO |
baicalin results in increased activity of NOTCH1 protein baicalin results in increased expression of NOTCH1 mRNA |
CTD |
PMID:19160421 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Pkm |
pyruvate kinase M1/2 |
increases activity |
ISO |
baicalin results in increased activity of PKM protein |
CTD |
PMID:25388478 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein] |
CTD |
PMID:24312512 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prima1 |
proline rich membrane anchor 1 |
increases expression |
EXP |
baicalin results in increased expression of PRIMA1 mRNA |
CTD |
PMID:27019979 |
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NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
EXP |
baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein |
CTD |
PMID:22019745 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
baicalin affects the localization of and results in decreased expression of RELA protein |
CTD |
PMID:22019745 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tek |
TEK receptor tyrosine kinase |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in decreased expression of TEK mRNA] |
CTD |
PMID:34414639 |
|
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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G |
Tfam |
transcription factor A, mitochondrial |
decreases expression multiple interactions |
ISO |
baicalin results in decreased expression of TFAM mRNA baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA] |
CTD |
PMID:36446982 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in decreased expression of TGFB1 mRNA]; baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] |
CTD |
PMID:19474275 PMID:34414639 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tlr4 |
toll-like receptor 4 |
decreases expression multiple interactions |
EXP |
baicalin results in decreased expression of TLR4 protein baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] |
CTD |
PMID:22019745 PMID:24312512 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO EXP |
baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein] |
CTD |
PMID:16824337 PMID:18187930 PMID:22019745 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
baicalin results in increased expression of TP53 protein |
CTD |
PMID:21457722 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txnip |
thioredoxin interacting protein |
multiple interactions |
ISO |
baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]] |
CTD |
PMID:29031535 |
|
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Usp27x |
ubiquitin specific peptidase 27, X-linked |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in increased expression of USP27X protein] |
CTD |
PMID:34414639 |
|
NCBI chr X:15,123,620...15,126,855
Ensembl chr X:15,124,596...15,125,912
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G |
Vegfc |
vascular endothelial growth factor C |
multiple interactions |
EXP |
baicalin inhibits the reaction [Streptozocin results in decreased expression of VEGFC mRNA] |
CTD |
PMID:34414639 |
|
NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
baicalin inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein] |
CTD |
PMID:34044073 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Comt |
catechol-O-methyltransferase |
increases methylation |
ISO EXP |
COMT protein results in increased methylation of Benserazide |
CTD |
PMID:11160877 |
|
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Ddc |
dopa decarboxylase |
multiple interactions |
ISO |
Benserazide binds to and results in decreased activity of DDC protein |
CTD |
PMID:35151785 |
|
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
EXP |
[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein] |
CTD |
PMID:19399396 |
|
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein] |
CTD |
PMID:19399396 |
|
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of BAX protein] Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]] |
CTD |
PMID:34560070 PMID:35202708 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] |
CTD |
PMID:34560070 PMID:35202708 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] |
CTD |
PMID:34560070 PMID:35202708 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] |
CTD |
PMID:34560070 PMID:35202708 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Comt |
catechol-O-methyltransferase |
increases methylation |
ISO EXP |
COMT protein results in increased methylation of Carbidopa |
CTD |
PMID:11160877 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Ddc |
dopa decarboxylase |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA] Carbidopa binds to and results in decreased activity of DDC protein |
CTD |
PMID:35151785 PMID:35202708 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
ISO |
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]] |
CTD |
PMID:35202708 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
ISO |
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]] |
CTD |
PMID:35202708 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]] |
CTD |
PMID:35202708 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of IL1B protein] |
CTD |
PMID:34560070 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]] |
CTD |
PMID:34560070 PMID:35202708 |
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NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Mfn1 |
mitofusin 1 |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]] |
CTD |
PMID:35202708 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
multiple interactions |
ISO |
Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]] |
CTD |
PMID:35202708 |
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NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-cyb |
mitochondrially encoded cytochrome b |
multiple interactions |
ISO |
Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]] |
CTD |
PMID:35202708 |
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NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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G |
Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]] |
CTD |
PMID:35202708 |
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NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] |
CTD |
PMID:34560070 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; Carbidopa inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:34560070 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; Carbidopa inhibits the reaction [Cisplatin results in increased secretion of TNF protein] |
CTD |
PMID:34560070 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tph1 |
tryptophan hydroxylase 1 |
multiple interactions |
ISO |
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein] |
CTD |
PMID:35202708 |
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NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] |
CTD |
PMID:29653099 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO |
herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] |
CTD |
PMID:29653099 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] |
CTD |
PMID:29653099 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] |
CTD |
PMID:29653099 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] |
CTD |
PMID:29653099 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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