Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
go back to main search page
Accession:CHEBI:76663 term browser browse the term
Definition:A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*).
Synonyms:related_synonym: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors;   EC 2.5.1.* inhibitor;   EC 2.5.1.* inhibitors;   non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor;   non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors;   non-methyl alkyl/aryl transferase inhibitor;   non-methyl alkyl/aryl transferase inhibitors;   non-methyl-alkyl or aryl transferase inhibitor;   non-methyl-alkyl or aryl transferase inhibitors



show annotations for term's descendants           Sort by:
 
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552
JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116
JBrowse link
glyphosate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase increases activity EXP glyphosate results in increased activity of CAT protein CTD PMID:31677563 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CLDN1 claudin 1 decreases expression EXP glyphosate results in decreased expression of CLDN1 mRNA CTD PMID:31677563 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases expression EXP glyphosate results in decreased expression of GCLM mRNA CTD PMID:31677563 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP glyphosate results in decreased expression of GPX1 mRNA CTD PMID:31677563 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression EXP glyphosate results in decreased expression of HMOX1 mRNA CTD PMID:31677563
G IL6 interleukin 6 increases expression EXP glyphosate results in increased expression of IL6 mRNA CTD PMID:31677563 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression EXP glyphosate results in increased expression of NFE2L2 mRNA; glyphosate results in increased expression of NFE2L2 protein CTD PMID:31677563 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression EXP glyphosate results in increased expression of NFKB1 mRNA CTD PMID:31677563 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP glyphosate results in increased expression of NQO1 mRNA CTD PMID:31677563 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP glyphosate results in decreased expression of TJP1 mRNA CTD PMID:31677563 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
hypochlorous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions EXP Hypochlorous Acid inhibits the reaction [NOS3 protein binds to NOS3 protein] CTD PMID:17762155 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
phenethyl caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein] CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP rosmarinic acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression EXP sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein CTD PMID:16005169 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein CTD PMID:16005169 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 1208
    role 1151
      biological role 1151
        biochemical role 1033
          enzyme inhibitor 453
            EC 2.* (transferase) inhibitor 104
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 20
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 20
                  EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor + 0
                  EC 2.5.1.117 (homogentisate solanesyltransferase) inhibitor + 0
                  EC 2.5.1.15 (dihydropteroate synthase) inhibitor + 3
                  EC 2.5.1.18 (glutathione transferase) inhibitor + 6
                  EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor + 10
                  EC 2.5.1.21 (squalene synthase) inhibitor + 0
                  EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitor + 0
                  EC 2.5.1.31 \{ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\} inhibitor + 0
                  EC 2.5.1.46 (deoxyhypusine synthase) inhibitor + 0
                  EC 2.5.1.48 (cystathionine gamma-synthase) inhibitor + 0
                  EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor + 0
                  EC 2.5.1.58 (protein farnesyltransferase) inhibitor + 0
                  EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor + 0
                  EC 2.5.1.6 (methionine adenosyltransferase) inhibitor + 0
                  EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor + 2
                  EC 2.5.1.9 (riboflavin synthase) inhibitor + 0
paths to the root