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ONTOLOGY REPORT - ANNOTATIONS


Term:macitentan
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Accession:CHEBI:76607 term browser browse the term
Definition:A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.
Synonyms:exact_synonym: N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'-propylsulfuric diamide
 related_synonym: ACT 064992;   ACT064992;   Formula=C19H20Br2N6O4S;   InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27);   InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N;   OPSUMIT;   SMILES=CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1;   macitentanum
 xref: CAS:441798-33-0;   Drug_Central:4809;   KEGG:D10135
 xref_mesh: MESH:C533860
 xref: PMID:21403842;   PMID:22189899;   PMID:22311911;   PMID:22348175;   PMID:22458347;   PMID:22525377;   PMID:22862294;   PMID:23068290;   PMID:23077657;   PMID:23192269;   PMID:23204120;   PMID:23353592;   PMID:23568224;   PMID:23682110;   PMID:23817130;   PMID:23830395;   PMID:23900878;   PMID:23984728;   PMID:23997048;   PMID:24122306;   PMID:24122797;   PMID:24249746;   PMID:24261583;   PMID:24297706;   Patent:US2008233188;   Patent:WO2007119214;   Patent:WO2008026156;   Reaxys:11340634;   Wikipedia:Macitentan


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macitentan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        solvent 16446
          ethylene glycol 135
            macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      chalcogen 19378
                        oxygen atom 19339
                          oxygen molecular entity 19339
                            hydroxides 19079
                              oxoacid 18174
                                chalcogen oxoacid 11481
                                  sulfur oxoacid 11081
                                    sulfuric acid 8012
                                      sulfuric acid derivative 8012
                                        sulfuric amide 17
                                          sulfamides 17
                                            ACT-132577 4
                                              macitentan 4
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