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ONTOLOGY REPORT - ANNOTATIONS


Term:macitentan
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Accession:CHEBI:76607 term browser browse the term
Definition:A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.
Synonyms:exact_synonym: N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'-propylsulfuric diamide
 related_synonym: ACT 064992;   ACT064992;   Formula=C19H20Br2N6O4S;   InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27);   InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N;   OPSUMIT;   SMILES=CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1;   macitentanum
 xref: CAS:441798-33-0 "ChemIDplus";   CAS:441798-33-0 "KEGG DRUG";   Drug_Central:4809 "DrugCentral";   KEGG:D10135
 xref_mesh: MESH:C533860
 xref: PMID:21403842 "Europe PMC";   PMID:22189899 "Europe PMC";   PMID:22311911 "Europe PMC";   PMID:22348175 "Europe PMC";   PMID:22458347 "Europe PMC";   PMID:22525377 "Europe PMC";   PMID:22862294 "Europe PMC";   PMID:23068290 "Europe PMC";   PMID:23077657 "Europe PMC";   PMID:23192269 "Europe PMC";   PMID:23204120 "Europe PMC";   PMID:23353592 "Europe PMC";   PMID:23568224 "Europe PMC";   PMID:23682110 "Europe PMC";   PMID:23817130 "Europe PMC";   PMID:23830395 "Europe PMC";   PMID:23900878 "Europe PMC";   PMID:23984728 "Europe PMC";   PMID:23997048 "Europe PMC";   PMID:24122306 "Europe PMC";   PMID:24122797 "Europe PMC";   PMID:24249746 "Europe PMC";   PMID:24261583 "Europe PMC";   PMID:24297706 "Europe PMC";   Patent:US2008233188;   Patent:WO2007119214;   Patent:WO2008026156;   Reaxys:11340634 "Reaxys";   Wikipedia:Macitentan


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macitentan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      application 19155
        solvent 16048
          ethylene glycol 105
            macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      chalcogen 19201
                        oxygen atom 19155
                          oxygen molecular entity 19155
                            hydroxides 18944
                              oxoacid 18019
                                chalcogen oxoacid 11375
                                  sulfur oxoacid 10962
                                    sulfuric acid 7899
                                      sulfuric acid derivative 7899
                                        sulfuric amide 17
                                          sulfamides 17
                                            ACT-132577 4
                                              macitentan 4
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