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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidazoquinoxaline
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Accession:CHEBI:76605 term browser browse the term
Definition:Any organic heterotricyclic compound with a skeleton consisting of an imidazole ring ortho-fused to a quinoxaline.
Synonyms:related_synonym: imidazoquinoxalines


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MeIQx term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:18322075 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ABCC9 mRNA CTD PMID:20816883 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ABCD3 mRNA CTD PMID:20816883 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:18322075 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ACSS1 mRNA CTD PMID:20816883 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ADORA2B mRNA CTD PMID:20816883 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adss adenylosuccinate synthase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ADSS2 mRNA CTD PMID:20816883 NCBI chr13:95,913,426...95,943,761
Ensembl chr13:95,913,426...95,943,761
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of AHR protein
CTD PMID:20816883, PMID:27644595 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ALDH3A1 mRNA CTD PMID:20816883 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Anln anillin, actin binding protein increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ANLN mRNA CTD PMID:20816883 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of APAF1 mRNA CTD PMID:20816883 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Arg1 arginase 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ARG1 mRNA CTD PMID:20816883 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects response to substance ISO ARNT protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:23208499 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ASAP1 mRNA CTD PMID:20816883 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ATP11B mRNA CTD PMID:20816883 NCBI chr 2:122,337,757...122,445,090
Ensembl chr 2:122,368,265...122,444,878
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of BAX mRNA CTD PMID:23810796 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 protein CTD PMID:23810796 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C1qtnf7 C1q and TNF related 7 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of C1QTNF7 mRNA CTD PMID:20816883 NCBI chr14:72,011,518...72,122,257
Ensembl chr14:72,011,461...72,122,158
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CACNA1D mRNA CTD PMID:20816883 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased activity of CASP3 protein
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased activity of CASP3 protein
CTD PMID:20307560 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CASP8 mRNA CTD PMID:20816883 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccdc47 coiled-coil domain containing 47 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CCDC47 mRNA CTD PMID:20816883 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL2 mRNA CTD PMID:23681119 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL3 mRNA CTD PMID:23681119 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA CTD PMID:23681119 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL7 mRNA CTD PMID:23681119 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNA2 mRNA CTD PMID:23681119 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB1 mRNA CTD PMID:23681119 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB2 mRNA CTD PMID:23681119 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCND1 mRNA CTD PMID:23681119 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA CTD PMID:23681119 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA CTD PMID:23681119
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR7 mRNA CTD PMID:23681119 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDC25C mRNA CTD PMID:20816883 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK1 mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA
CTD PMID:20816883, PMID:23681119 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK13 mRNA CTD PMID:20816883 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDKN1A mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDKN1A protein CTD PMID:23810796 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases phosphorylation
affects response to substance
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased phosphorylation of CEBPB protein
CEBPB protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CTD PMID:23208499 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cep55 centrosomal protein 55 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CEP55 mRNA CTD PMID:20816883 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796
JBrowse link
G Cfap45 cilia and flagella associated protein 45 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CFAP45 mRNA CTD PMID:20816883 NCBI chr13:90,909,551...90,932,958
Ensembl chr13:90,909,486...90,932,961
JBrowse link
G Cfhr2 complement factor H-related 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CFHR4 mRNA CTD PMID:20816883 NCBI chr13:56,641,657...56,713,305
Ensembl chr13:56,642,365...56,693,968
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA CTD PMID:23681119 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cldn14 claudin 14 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CLDN14 mRNA CTD PMID:20816883 NCBI chr11:34,132,581...34,142,813
Ensembl chr11:34,132,581...34,142,753
JBrowse link
G Clybl citramalyl-CoA lyase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CLYBL mRNA CTD PMID:20816883 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
G Col9a2 collagen type IX alpha 2 chain increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of COL9A2 mRNA CTD PMID:20816883 NCBI chr 5:139,962,684...139,979,865
Ensembl chr 5:139,963,002...139,979,864
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CSGALNACT1 mRNA CTD PMID:20816883 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
affects activity
ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A1 mRNA
CYP1A1 affects the activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CTD PMID:2334931, PMID:20307560, PMID:20816883, PMID:22138251, PMID:23681119, PMID:23810796, PMID:27644595 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
affects oxidation
increases oxidation
increases activity
affects metabolic processing
decreases activity
ISO
EXP
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; [CYP1A2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] which results in increased chemical synthesis of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline metabolite; [CYP1A2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] which results in increased chemical synthesis of 2-amino-4-hydroxymethyl-3,8-dimethylimidazo(4,5-f)quinoxaline; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 protein]; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with alpha-naphthoflavone] results in increased expression of CYP1A2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Carbon Tetrachloride] results in increased expression of CYP1A2 mRNA; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein]
CYP1A2 affects the oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein
CYP1A2 protein results in increased oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; CYP1A2 results in increased oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased activity of CYP1A2 protein; CYP1A2 results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CYP1A2 protein affects the metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CYP1A2 protein results in decreased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CTD PMID:2334931, PMID:2655891, PMID:9202738, PMID:9581821, PMID:10503887, PMID:10503888, PMID:12079509, PMID:14965361, PMID:20192249, PMID:20307560, PMID:20448087, PMID:20816883, PMID:20930465, PMID:22118226, PMID:22138251, PMID:23681119, PMID:23810796, PMID:27644595, PMID:28160022 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
affects response to substance
multiple interactions
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1B1 mRNA
CYP1B1 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1B1 mRNA
CTD PMID:19223546, PMID:20307560, PMID:20816883 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions EXP CYP2A3 protein results in increased metabolism of and results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:8403195 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP2B10 mRNA CTD PMID:23681119 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP2C11 mRNA CTD PMID:14965361 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYP2C8 mRNA CTD PMID:20816883 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of CYP7B1 mRNA CTD PMID:23681119 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dapl1 death associated protein-like 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DAPL1 mRNA CTD PMID:20816883 NCBI chr 3:45,538,408...45,559,281
Ensembl chr 3:45,538,797...45,559,331
JBrowse link
G Ddx42 DEAD-box helicase 42 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DDX42 mRNA CTD PMID:20816883 NCBI chr10:94,407,094...94,439,052
Ensembl chr10:94,407,559...94,439,052
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DHRS2 mRNA CTD PMID:20816883 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DIAPH3 mRNA CTD PMID:20816883 NCBI chr15:69,928,507...70,400,077
Ensembl chr15:70,039,424...70,399,924
JBrowse link
G Dmxl2 Dmx-like 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DMXL2 mRNA CTD PMID:20816883 NCBI chr 8:58,932,575...59,077,788
Ensembl chr 8:58,932,580...59,077,690
JBrowse link
G Duox2 dual oxidase 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUOX2 mRNA CTD PMID:20816883 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Dusp16 dual specificity phosphatase 16 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUSP16 mRNA CTD PMID:20816883 NCBI chr 4:168,470,141...168,551,346
Ensembl chr 4:168,472,412...168,517,177
JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of E2F7 mRNA CTD PMID:20816883 NCBI chr 7:53,275,659...53,318,261
Ensembl chr 7:53,275,676...53,316,481
JBrowse link
G Egr1 early growth response 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of EGR1 mRNA CTD PMID:20816883 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eps8l3 EPS8 like 3 affects response to substance ISO EPS8L3 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:19223546 NCBI chr 2:210,668,249...210,681,930
Ensembl chr 2:210,668,403...210,681,796
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ERCC1 mRNA CTD PMID:22100608 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ERCC6L mRNA CTD PMID:20816883 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ESCO2 mRNA CTD PMID:20816883 NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of ESR1 protein
CTD PMID:16533016 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Exo1 exonuclease 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA CTD PMID:23681119 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FHIT mRNA CTD PMID:22100608 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FOS mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of FOS mRNA
CTD PMID:20816883, PMID:23681119 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fsd1 fibronectin type III and SPRY domain containing 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FSD1 mRNA CTD PMID:20816883 NCBI chr 9:11,076,670...11,080,190
Ensembl chr 9:11,067,369...11,080,155
JBrowse link
G Gabpb1 GA binding protein transcription factor subunit beta 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GABPB1 mRNA CTD PMID:20816883 NCBI chr 3:119,091,739...119,135,391
Ensembl chr 3:119,091,744...119,135,391
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GADD45A mRNA CTD PMID:23810796 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gjc3 gap junction protein, gamma 3 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GJC3 mRNA CTD PMID:20816883 NCBI chr12:19,166,074...19,177,701
Ensembl chr12:19,166,239...19,167,015
JBrowse link
G Gnat1 G protein subunit alpha transducin 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNAT1 mRNA CTD PMID:20816883 NCBI chr 8:116,433,302...116,438,038
Ensembl chr 8:116,433,302...116,438,038
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNMT mRNA CTD PMID:20816883, PMID:22100608 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Gpatch1 G patch domain containing 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GPATCH1 mRNA CTD PMID:20816883 NCBI chr 1:91,529,096...91,578,032
Ensembl chr 1:91,529,112...91,578,048
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GSTA1 mRNA CTD PMID:22138251, PMID:23810796 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:22564066 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:19223546 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects response to substance ISO GSTT1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:22564066 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of H6PD mRNA CTD PMID:20816883 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of HIPK3 mRNA CTD PMID:20816883 NCBI chr 3:94,349,778...94,419,185
Ensembl chr 3:94,352,969...94,419,048
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of HMOX1 mRNA
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of HMOX1 mRNA
CTD PMID:20307560 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HPRT1 gene CTD PMID:12467141 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HRAS gene CTD PMID:2009133 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of IL1B mRNA CTD PMID:23681119 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il36b interleukin 36, beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of IL1F8 mRNA CTD PMID:23681119 NCBI chr 3:1,366,123...1,464,851
Ensembl chr 3:1,366,119...1,371,626
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of IL3RA mRNA CTD PMID:20816883 NCBI chr12:18,534,762...18,542,508
Ensembl chr12:18,534,767...18,540,166
JBrowse link
G Impg2 interphotoreceptor matrix proteoglycan 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of IMPG2 mRNA CTD PMID:20816883 NCBI chr11:46,615,091...46,693,565
Ensembl chr11:46,615,200...46,693,565
JBrowse link
G Incenp inner centromere protein increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INCENP mRNA CTD PMID:20816883 NCBI chr 1:225,923,448...225,953,384
Ensembl chr 1:225,925,773...225,952,516
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INPP5D mRNA CTD PMID:20816883 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of JUN mRNA CTD PMID:23681119 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KCNV1 mRNA CTD PMID:20816883 NCBI chr 7:84,016,864...84,023,205
Ensembl chr 7:84,015,207...84,023,316
JBrowse link
G Kctd2 potassium channel tetramerization domain containing 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KCTD2 mRNA CTD PMID:20816883 NCBI chr10:103,972,700...103,984,398
Ensembl chr10:103,972,888...103,984,402
JBrowse link
G Kif1b kinesin family member 1B increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KIF1B mRNA CTD PMID:20816883 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KIFC1 mRNA CTD PMID:20816883 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
JBrowse link
G Klf1 Kruppel like factor 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KLF1 mRNA CTD PMID:20816883 NCBI chr19:26,016,289...26,019,557
Ensembl chr19:26,016,382...26,019,553
JBrowse link
G Klf6 Kruppel-like factor 6 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KLF6 mRNA CTD PMID:20816883 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of KRAS gene CTD PMID:18271921 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lama1 laminin subunit alpha 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of LAMA1 mRNA CTD PMID:20816883 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of LIF mRNA CTD PMID:20816883 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G LOC100911204 protein CASC5-like increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KNL1 mRNA CTD PMID:20816883 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
JBrowse link
G Lrrc58 leucine rich repeat containing 58 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of LRRC58 mRNA CTD PMID:20816883 NCBI chr11:65,747,235...65,759,558
Ensembl chr11:65,747,036...65,759,581
JBrowse link
G Ltf lactotransferrin multiple interactions EXP LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein] CTD PMID:12079509 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mat2a methionine adenosyltransferase 2A increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MAT2A mRNA CTD PMID:20816883 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MKI67 mRNA CTD PMID:20816883 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYTB mRNA CTD PMID:20816883 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
increases acetylation
increases response to substance
ISO
EXP
[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
NAT2 protein results in increased acetylation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
NAT2 protein results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
[Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of NAT2 mRNA
CTD PMID:7625840, PMID:19666988, PMID:22138251, PMID:23681119, PMID:28160022 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nek2 NIMA-related kinase 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NEK2 mRNA CTD PMID:20816883 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NFE2L2 mRNA
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of NFE2L2 mRNA
CTD PMID:20307560 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NFKB2 mRNA CTD PMID:23681119 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nmu neuromedin U increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NMU mRNA CTD PMID:20816883 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of NR0B2 mRNA CTD PMID:20816883 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:9581821, PMID:10503888 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ORC1 mRNA CTD PMID:20816883 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Pdzd7 PDZ domain containing 7 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PDZD7 mRNA CTD PMID:20816883 NCBI chr 1:264,776,393...264,796,206
Ensembl chr 1:264,776,398...264,794,938
JBrowse link
G Pgm5 phosphoglucomutase 5 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PGM5 mRNA CTD PMID:20816883 NCBI chr 1:242,582,591...242,765,837
Ensembl chr 1:242,582,642...242,765,807
JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PIM2 mRNA CTD PMID:22100608 NCBI chr  X:15,462,621...15,467,890
Ensembl chr  X:15,462,016...15,467,875
JBrowse link
G Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PIP5KL1 mRNA CTD PMID:20816883 NCBI chr 3:11,592,156...11,597,513
Ensembl chr 3:11,593,655...11,597,410
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:9581821, PMID:10503888 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Poted POTE ankyrin domain family member D increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of POTED mRNA CTD PMID:20816883 NCBI chr17:66,634,457...66,668,342
Ensembl chr17:66,657,755...66,667,853
JBrowse link
G Prss21 serine protease 21 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PRSS21 mRNA CTD PMID:20816883 NCBI chr10:13,214,343...13,219,994
Ensembl chr10:13,214,130...13,219,894
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:11159734 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:11159734 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rab7b Rab7b, member RAS oncogene family increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAB7B mRNA CTD PMID:20816883 NCBI chr13:48,456,143...48,483,714
Ensembl chr13:48,455,923...48,482,138
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA CTD PMID:23681119 NCBI chr 4:144,537,329...144,620,606
Ensembl chr 4:144,536,729...144,620,731
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAD23B mRNA CTD PMID:20816883 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA CTD PMID:23681119 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD51AP1 mRNA CTD PMID:20816883 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Rad54l RAD54 like increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD54L mRNA CTD PMID:20816883 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAPGEF1 mRNA CTD PMID:20816883 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RBBP6 mRNA CTD PMID:20816883 NCBI chr 1:192,933,264...192,965,160
Ensembl chr 1:192,933,540...192,965,158
JBrowse link
G Rnf125 ring finger protein 125 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RNF125 mRNA CTD PMID:20816883 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RNF186 mRNA CTD PMID:20816883 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RPS6KA5 mRNA CTD PMID:20816883 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RRM2 mRNA CTD PMID:20816883 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Serpini2 serpin family I member 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SERPINI2 mRNA CTD PMID:20816883 NCBI chr 2:173,640,385...173,670,790
Ensembl chr 2:173,640,385...173,668,555
JBrowse link
G Shcbp1 SHC binding and spindle associated 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SHCBP1 mRNA CTD PMID:20816883 NCBI chr16:90,613,826...90,642,683
Ensembl chr16:90,613,870...90,641,420
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SLC15A1 mRNA CTD PMID:20816883 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A2 protein
CTD PMID:30189235 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity
ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A3 protein
CTD PMID:30189235 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SLC7A11 mRNA CTD PMID:20816883 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smyd3 SET and MYND domain containing 3 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SMYD3 mRNA CTD PMID:22100608 NCBI chr13:97,330,120...97,807,813 JBrowse link
G Tas2r120 taste receptor, type 2, member 120 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TAS2R20 mRNA CTD PMID:20816883 NCBI chr 4:166,833,320...166,834,207
Ensembl chr 4:166,833,320...166,834,207
JBrowse link
G Tbc1d25 TBC1 domain family, member 25 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TBC1D25 mRNA CTD PMID:20816883 NCBI chr  X:15,064,733...15,088,579
Ensembl chr  X:15,064,594...15,088,589
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of TNF mRNA CTD PMID:23681119 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TNFSF9 mRNA CTD PMID:20816883 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TOP2A mRNA CTD PMID:20816883 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis
increases expression
EXP
ISO
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of TP53 gene
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TP53 protein
CTD PMID:8844820, PMID:23810796 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trappc9 trafficking protein particle complex 9 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TRAPPC9 mRNA CTD PMID:22100608 NCBI chr 7:113,986,363...114,309,090
Ensembl chr 7:113,681,793...114,305,896
JBrowse link
G Trim63 tripartite motif containing 63 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TRIM63 mRNA CTD PMID:20816883 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Trim72 tripartite motif containing 72 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TRIM72 mRNA CTD PMID:20816883 NCBI chr 1:199,450,042...199,457,902
Ensembl chr 1:199,449,973...199,457,895
JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UBE2J2 mRNA CTD PMID:20816883 NCBI chr 5:173,372,659...173,387,084
Ensembl chr 5:173,372,669...173,387,104
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UGT1A1 mRNA CTD PMID:22138251, PMID:23810796 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of UGT2B1 mRNA CTD PMID:23681119 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UHRF1 mRNA CTD PMID:20816883 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vamp1 vesicle-associated membrane protein 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of VAMP1 mRNA CTD PMID:20816883 NCBI chr 4:157,726,941...157,733,644
Ensembl chr 4:157,726,941...157,733,643
JBrowse link
G Vil1 villin 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of VIL1 mRNA CTD PMID:20816883 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of WASL mRNA CTD PMID:20816883 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of YAP1 mRNA CTD PMID:20816883 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Zfp799 zinc finger protein 799 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ZNF799 mRNA CTD PMID:20816883 NCBI chr 7:15,066,960...15,079,624
Ensembl chr 7:15,069,254...15,073,052
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          nitrogen atom 18539
            nitrogen molecular entity 18539
              organonitrogen compound 18309
                organonitrogen heterocyclic compound 17460
                  imidazoquinoxaline 165
                    MeIQx + 165
                    N-hydroxy-MeIQx 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotricyclic compound 14571
                                      imidazoquinoxaline 165
                                        MeIQx + 165
                                        N-hydroxy-MeIQx 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.