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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nystatin
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Accession:CHEBI:7660 term browser browse the term
Definition:A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptococcus species. The keto-form of nystatin A1.
Synonyms:exact_synonym: (21E,23E,25E,27E,31E,33E)-20-[(3-amino-3,6-dideoxy-D-mannopyranosyl)oxy]-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxooxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid
 related_synonym: Formula=C47H75NO17;   InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-35(65-47-45(60)42(48)44(59)30(4)64-47)26-39(56)41(46(61)62)38(55)24-34(52)23-37(54)36(53)20-19-31(49)21-32(50)22-33(51)25-40(57)63-29(3)28(2)43(27)58/h5-6,8,10-18,27-33,35-39,41-45,47,49-51,53-56,58-60H,7,9,19-26,48H2,1-4H3,(H,61,62)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27?,28?,29?,30-,31?,32?,33?,35?,36?,37?,38?,39?,41?,42+,43?,44-,45+,47?/m1/s1;   InChIKey=ZDFDJJJGIRGMBE-AFARJNEBSA-N;   SMILES=CC1OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)CC(=O)CC(O)C(C(O)CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)\\C=C\\C=C\\C=C\\C=C\\CC\\C=C\\C=C\\C(C)C(O)C1C)C(O)=O;   mycostatin
 xref: DrugBank:DB00646;   KEGG:D00202;   LIPID_MAPS_instance:LMPK06000001
 xref_mesh: MESH:D009761


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nystatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Nystatin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Nystatin inhibits the reaction [resveratrol affects the localization of CASP8 protein] CTD PMID:12902349 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Nystatin inhibits the reaction [Quercetin affects the localization of CAV1 protein] CTD PMID:17876056 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cd40 CD40 molecule increases expression ISO Nystatin results in increased expression of CD40 protein CTD PMID:16374455 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Nystatin results in increased expression of CD80 protein CTD PMID:16374455 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression ISO Nystatin results in increased expression of CD86 protein CTD PMID:16374455 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Clu clusterin increases expression ISO Nystatin results in increased expression of CLU mRNA CTD PMID:22863853 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cp ceruloplasmin increases expression ISO Nystatin results in increased expression of CP mRNA CTD PMID:22863853 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO Nystatin inhibits the reaction [resveratrol affects the localization of FADD protein] CTD PMID:12902349 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Nystatin inhibits the reaction [resveratrol affects the localization of FAS protein] CTD PMID:12902349 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Nystatin results in increased expression of FGA mRNA CTD PMID:22863853 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgg fibrinogen gamma chain increases expression ISO Nystatin results in increased expression of FGG mRNA CTD PMID:22863853 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nystatin results in increased expression of HAVCR1 mRNA CTD PMID:22863853 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Nystatin results in increased expression of ICAM1 protein CTD PMID:16374455 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nystatin results in increased expression of IL1B mRNA; Nystatin results in increased expression of IL1B protein CTD PMID:16374455 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO Nystatin results in increased expression of IL6 protein CTD PMID:16374455 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Krt18 keratin 18 increases expression ISO Nystatin results in increased expression of KRT18 mRNA CTD PMID:22863853 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression ISO Nystatin results in increased expression of KRT19 mRNA CTD PMID:22863853 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt8 keratin 8 increases expression ISO Nystatin results in increased expression of KRT8 mRNA CTD PMID:22863853 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Nystatin results in increased expression of LCN2 mRNA CTD PMID:22863853 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [4-propylphenol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein] CTD PMID:15072920 PMID:22230296 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [4-propylphenol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein] CTD PMID:15072920 PMID:22230296 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Prnp prion protein multiple interactions ISO Nystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein] CTD PMID:11994310 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit increases activity ISO Nystatin results in increased activity of REL protein CTD PMID:16374455 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity ISO Nystatin results in increased activity of RELA protein CTD PMID:16374455 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Nystatin results in increased expression of SPP1 mRNA CTD PMID:22863853 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Nystatin results in increased expression of TIMP1 mRNA CTD PMID:22863853 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Nystatin inhibits the reaction [Quercetin affects the localization of TNFRSF10A protein] CTD PMID:17876056 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Vim vimentin increases expression ISO Nystatin results in increased expression of VIM mRNA CTD PMID:22863853 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        antimicrobial agent 17379
          macrolide antibiotic 395
            nystatins 29
              nystatin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic ester 15517
                                        lactone 9734
                                          macrocyclic lactone 1763
                                            macrolide 1634
                                              macrolide antibiotic 395
                                                nystatins 29
                                                  nystatin 29
paths to the root