CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: triradylglycerol
Accession: CHEBI:76579
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Definition: A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)
Synonyms: related_synonym: triradylglycerols
xref: LIPID_MAPS_class:LMGL0301
G
Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
trilinolenin results in decreased expression of ABCA1 mRNA
CTD
PMID:18356535
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression
ISO
trilinolenin results in decreased expression of ABCG5 mRNA
CTD
PMID:18356535
NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
G
Abcg8
ATP binding cassette subfamily G member 8
decreases expression
ISO
trilinolenin results in decreased expression of ABCG8 mRNA
CTD
PMID:18356535
NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
trilinolenin results in decreased expression of CYP27A1 mRNA
CTD
PMID:18356535
NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
ISO
trilinolenin results in increased expression of HMGCR mRNA
CTD
PMID:18356535
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Mttp
microsomal triglyceride transfer protein
increases expression
ISO
trilinolenin results in increased expression of MTTP mRNA
CTD
PMID:18356535
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
G
Npc1l1
NPC1 like intracellular cholesterol transporter 1
decreases expression
ISO
trilinolenin results in decreased expression of NPC1L1 mRNA
CTD
PMID:18356535
NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
G
Scd
stearoyl-CoA desaturase
decreases expression
ISO
trilinolenin results in decreased expression of SCD1 mRNA
CTD
PMID:8729090
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
G
Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
trilinolein results in decreased expression of ABCA1 mRNA
CTD
PMID:18356535
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression
ISO
trilinolein results in decreased expression of ABCG5 mRNA
CTD
PMID:18356535
NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
G
Abcg8
ATP binding cassette subfamily G member 8
decreases expression
ISO
trilinolein results in decreased expression of ABCG8 mRNA
CTD
PMID:18356535
NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
trilinolein results in decreased expression of CYP27A1 mRNA
CTD
PMID:18356535
NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
ISO
trilinolein results in increased expression of HMGCR mRNA
CTD
PMID:18356535
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Mttp
microsomal triglyceride transfer protein
increases expression
ISO
trilinolein results in increased expression of MTTP mRNA
CTD
PMID:18356535
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
G
Npc1l1
NPC1 like intracellular cholesterol transporter 1
decreases expression
ISO
trilinolein results in decreased expression of NPC1L1 mRNA
CTD
PMID:18356535
NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
G
Scd
stearoyl-CoA desaturase
multiple interactions decreases expression
ISO
Clofibrate inhibits the reaction [trilinolein results in decreased expression of SCD1 mRNA]
CTD
PMID:8790349
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
G
Pafah1b1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
increases expression multiple interactions
EXP
Castor Oil results in increased expression of PAFAH1B1 protein isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein]
CTD
PMID:1354728 PMID:2743081 PMID:8738301
NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Biofuels co-treated with Triacetin] results in decreased expression of BCL2 mRNA
CTD
PMID:30738890
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp3
caspase 3
multiple interactions
ISO
[Biofuels co-treated with Triacetin] results in decreased expression of CASP3 mRNA
CTD
PMID:30738890
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
[Biofuels co-treated with Triacetin] affects the expression of CYP1A1 mRNA
CTD
PMID:30738890
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Triacetin results in increased expression of DDIT3 mRNA
CTD
PMID:21703327
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
[Biofuels co-treated with Triacetin] affects the expression of HMOX1 mRNA
CTD
PMID:30738890
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Scd
stearoyl-CoA desaturase
decreases expression multiple interactions
ISO
Triarachidonin results in decreased expression of SCD1 mRNA Clofibrate inhibits the reaction [Triarachidonin results in decreased expression of SCD1 mRNA]
CTD
PMID:8729090 PMID:8790349
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
tributyrin results in decreased expression of BCL2 mRNA
CTD
PMID:11876963
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Cd86
CD86 molecule
increases expression
ISO
tributyrin results in increased expression of CD86 protein
CTD
PMID:30503584
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
G
Ifng
interferon gamma
multiple interactions
ISO
[tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein
CTD
PMID:29198882
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
G
Il1b
interleukin 1 beta
increases expression
ISO
tributyrin results in increased expression of IL1B protein
CTD
PMID:30503584
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il2
interleukin 2
multiple interactions
ISO
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]; IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein]
CTD
PMID:16252257
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
G
Il4
interleukin 4
multiple interactions
ISO
[tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein
CTD
PMID:29198882
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Mapk1
mitogen activated protein kinase 1
affects phosphorylation multiple interactions
ISO
tributyrin affects the phosphorylation of MAPK1 protein IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]
CTD
PMID:16252257
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
multiple interactions affects phosphorylation
ISO
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein]
CTD
PMID:16252257
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Tlr2
toll-like receptor 2
multiple interactions
EXP
tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
CTD
PMID:21051124
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
G
Tnf
tumor necrosis factor
multiple interactions
EXP
tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:21051124
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
tributyrin results in increased activity of TRPA1 protein
CTD
PMID:29198882
NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
G
Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
Triolein results in decreased expression of ABCA1 mRNA
CTD
PMID:18356535
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression
ISO
Triolein results in decreased expression of ABCG5 mRNA
CTD
PMID:18356535
NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
G
Abcg8
ATP binding cassette subfamily G member 8
decreases expression
ISO
Triolein results in decreased expression of ABCG8 mRNA
CTD
PMID:18356535
NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
G
Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA]
CTD
PMID:15066988
NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
G
Apoa4
apolipoprotein A4
multiple interactions
EXP
[Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in increased expression of APOA4 protein
CTD
PMID:6631239
NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
G
Apoe
apolipoprotein E
multiple interactions
EXP
[Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in decreased expression of APOE protein
CTD
PMID:6631239
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
G
App
amyloid beta precursor protein
multiple interactions
EXP
Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]
CTD
PMID:28734741
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
G
Cat
catalase
multiple interactions
EXP
Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of CAT mRNA]
CTD
PMID:28734741
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
Triolein results in decreased expression of CYP27A1 mRNA
CTD
PMID:18356535
NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
G
Fasn
fatty acid synthase
multiple interactions
ISO
Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]
CTD
PMID:15066988
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
G
Gpx1
glutathione peroxidase 1
multiple interactions
EXP
Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]
CTD
PMID:28734741
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
ISO
Triolein results in increased expression of HMGCR mRNA
CTD
PMID:18356535
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Mttp
microsomal triglyceride transfer protein
increases expression
ISO
Triolein results in increased expression of MTTP mRNA
CTD
PMID:18356535
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
G
Npc1l1
NPC1 like intracellular cholesterol transporter 1
decreases expression
ISO
Triolein results in decreased expression of NPC1L1 mRNA
CTD
PMID:18356535
NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
G
Scd
stearoyl-CoA desaturase
multiple interactions
ISO
Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
CTD
PMID:15066988
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
G
Sod1
superoxide dismutase 1
multiple interactions
EXP
Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA]
CTD
PMID:28734741
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
G
Sod2
superoxide dismutase 2
multiple interactions
EXP
Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 mRNA]
CTD
PMID:28734741
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]
CTD
PMID:15066988
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
G
Fgf21
fibroblast growth factor 21
multiple interactions decreases secretion
ISO
FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride] FGF21 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride
CTD
PMID:28123933
NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
G
Lpl
lipoprotein lipase
increases hydrolysis multiple interactions increases activity
ISO
LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride [LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride] which results in increased abundance of Fatty Acids, Unsaturated; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]; very low density lipoprotein triglyceride affects the reaction [LPL protein results in decreased activity of TNF protein]
CTD
PMID:12573449 PMID:15994321 PMID:18435438
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
G
Lrp1
LDL receptor related protein 1
multiple interactions
ISO
very low density lipoprotein triglyceride promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of LRP1 mRNA]
CTD
PMID:15910848
NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
G
Mb
myoglobin
multiple interactions decreases secretion
EXP
alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride]
CTD
PMID:17478120
NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
G
Ppargc1b
PPARG coactivator 1 beta
increases abundance
ISO
PPARGC1B results in increased abundance of very low density lipoprotein triglyceride
CTD
PMID:17932310
NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
G
Sirt7
sirtuin 7
decreases secretion
ISO
SIRT7 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride
CTD
PMID:24210820
NCBI chr10:109,796,046...109,802,821
Ensembl chr10:109,796,020...109,802,739
G
Tnf
tumor necrosis factor
multiple interactions
ISO
very low density lipoprotein triglyceride affects the reaction [LPL protein results in decreased activity of TNF protein]
CTD
PMID:15994321
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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