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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triradylglycerol
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Accession:CHEBI:76579 term browser browse the term
Definition:A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)
Synonyms:related_synonym: triradylglycerols
 xref: LIPID_MAPS_class:LMGL0301


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1,2,3-trilinolenoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO trilinolenin results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO trilinolenin results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO trilinolenin results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO trilinolenin results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO trilinolenin results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO trilinolenin results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO trilinolenin results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO trilinolenin results in decreased expression of SCD1 mRNA CTD PMID:8729090 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
1,2,3-trilinoleoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO trilinolein results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO trilinolein results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO trilinolein results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO trilinolein results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO trilinolein results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO trilinolein results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO trilinolein results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression		 ISO Clofibrate inhibits the reaction [trilinolein results in decreased expression of SCD1 mRNA] CTD PMID:8790349 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
castor oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 increases expression
multiple interactions		 EXP Castor Oil results in increased expression of PAFAH1B1 protein
isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein]		 CTD PMID:1354728 PMID:2743081 PMID:8738301 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
triacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Biofuels co-treated with Triacetin] results in decreased expression of BCL2 mRNA CTD PMID:30738890 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Biofuels co-treated with Triacetin] results in decreased expression of CASP3 mRNA CTD PMID:30738890 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Biofuels co-treated with Triacetin] affects the expression of CYP1A1 mRNA CTD PMID:30738890 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Triacetin results in increased expression of DDIT3 mRNA CTD PMID:21703327 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Biofuels co-treated with Triacetin] affects the expression of HMOX1 mRNA CTD PMID:30738890 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
triarachidonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scd stearoyl-CoA desaturase decreases expression
multiple interactions		 ISO Triarachidonin results in decreased expression of SCD1 mRNA
Clofibrate inhibits the reaction [Triarachidonin results in decreased expression of SCD1 mRNA]		 CTD PMID:8729090 PMID:8790349 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
tributyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tributyrin results in decreased expression of BCL2 mRNA CTD PMID:11876963 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cd86 CD86 molecule increases expression ISO tributyrin results in increased expression of CD86 protein CTD PMID:30503584 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO tributyrin results in increased expression of IL1B protein CTD PMID:30503584 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]; IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein] CTD PMID:16252257 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein CTD PMID:29198882 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions		 ISO tributyrin affects the phosphorylation of MAPK1 protein
IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK1 protein]		 CTD PMID:16252257 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation		 ISO IL2 protein affects the reaction [tributyrin affects the phosphorylation of MAPK3 protein] CTD PMID:16252257 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:21051124 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21051124 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO tributyrin results in increased activity of TRPA1 protein CTD PMID:29198882 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
triolein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO Triolein results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Triolein results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO Triolein results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of ACACA mRNA] CTD PMID:15066988 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions EXP [Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in increased expression of APOA4 protein CTD PMID:6631239 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoe apolipoprotein E multiple interactions EXP [Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in decreased expression of APOE protein CTD PMID:6631239 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein] CTD PMID:28734741 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cat catalase multiple interactions EXP Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of CAT mRNA] CTD PMID:28734741 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Triolein results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA] CTD PMID:15066988 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA] CTD PMID:28734741 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Triolein results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO Triolein results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO Triolein results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased abundance of Triglycerides]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]] CTD PMID:15066988 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA] CTD PMID:28734741 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 mRNA] CTD PMID:28734741 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]] CTD PMID:15066988 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
very-low-density lipoprotein triglyceride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf21 fibroblast growth factor 21 multiple interactions
decreases secretion		 ISO FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]
FGF21 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride		 CTD PMID:28123933 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Lpl lipoprotein lipase increases hydrolysis
multiple interactions
increases activity		 ISO LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride
[LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride] which results in increased abundance of Fatty Acids, Unsaturated; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]; very low density lipoprotein triglyceride affects the reaction [LPL protein results in decreased activity of TNF protein]		 CTD PMID:12573449 PMID:15994321 PMID:18435438 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO very low density lipoprotein triglyceride promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of LRP1 mRNA] CTD PMID:15910848 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Mb myoglobin multiple interactions
decreases secretion		 EXP alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride] CTD PMID:17478120 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases abundance ISO PPARGC1B results in increased abundance of very low density lipoprotein triglyceride CTD PMID:17932310 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Sirt7 sirtuin 7 decreases secretion ISO SIRT7 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride CTD PMID:24210820 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO very low density lipoprotein triglyceride affects the reaction [LPL protein results in decreased activity of TNF protein] CTD PMID:15994321 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        osmolyte 2067
          glycerol 1786
            glycerolipid 276
              triradylglycerol 40
                alkyldiacylglyceride + 0
                alkyldiacylglycerol + 0
                triglyceride + 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            heteroorganic entity 19544
                              organochalcogen compound 19283
                                organooxygen compound 19228
                                  carbohydrates and carbohydrate derivatives 13915
                                    carbohydrate 13915
                                      alditol 1904
                                        glycerol 1786
                                          glycerolipid 276
                                            triradylglycerol 40
                                              alkyldiacylglyceride + 0
                                              alkyldiacylglycerol + 0
                                              triglyceride + 40
paths to the root