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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alloxan
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Accession:CHEBI:76451 term browser browse the term
Definition:A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Synonyms:exact_synonym: pyrimidine-2,4,5,6(1H,3H)-tetrone
 related_synonym: 2,4,5,6(1H,3H)-Pyrimidinetetrone;   2,4,5,6-Tetraoxohexahydropyrimidine;   2,4,5,6-pyrimidinetetrone;   5,6-dioxouracil;   5-oxobarbituric acid;   Alloxane;   Formula=C4H2N2O4;   InChI=1S/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10);   InChIKey=HIMXGTXNXJYFGB-UHFFFAOYSA-N;   Mesoxalylcarbamide;   Mesoxalylurea;   NSC 7169;   Pyrimidinetetrone;   SMILES=O=C1NC(=O)C(=O)C(=O)N1
 xref: CAS:50-71-5;   HMDB:HMDB0002818
 xref_mesh: MESH:D000496
 xref: MetaCyc:CPD-3684;   PDBeChem:LXN;   PMID:21344938;   PMID:23408741;   PMID:23473942;   PMID:23658878;   PMID:23667864;   PMID:23762986;   PMID:24129090;   PMID:24374440;   Reaxys:132451;   Wikipedia:Alloxan


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alloxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions
increases activity		 ISO Chromium inhibits the reaction [Alloxan results in increased activity of ACOX1 protein]; chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Actb actin, beta decreases expression EXP Alloxan results in decreased expression of ACTB mRNA CTD PMID:12137914 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Alloxan co-treated with Niacinamide] affects the expression of ADIPOQ protein CTD PMID:26429928 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions		 EXP
ISO		 Alloxan results in decreased phosphorylation of AKT1 protein
Phycocyanin inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]		 CTD PMID:26827782 PMID:33359794 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions
increases expression		 ISO Alloxan results in decreased expression of APAF1 protein
Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]		 CTD PMID:21982801 PMID:23092809 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 multiple interactions
decreases expression		 ISO imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of ATP2A1 protein] CTD PMID:28483572 NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 decreases expression ISO Alloxan results in decreased expression of ATP2A2 protein CTD PMID:28483572 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions		 ISO Alloxan results in increased expression of BAD protein
Taurine inhibits the reaction [Alloxan results in increased expression of BAD protein]		 CTD PMID:22138235 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 ISO Taurine inhibits the reaction [Alloxan results in increased expression of BAX protein] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of BCL2 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2 protein]		 CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of BCL2L1 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2L1 protein]		 CTD PMID:22138235 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP3 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP3 protein modified form] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions		 ISO Alloxan results in increased activity of CASP9 protein
Alloxan results in increased expression of CASP9 protein; Alloxan results in increased expression of CASP9 protein modified form
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP9 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein modified form]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein]		 CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity		 ISO
EXP		 3,4-dihydroxyphenylethanol inhibits the reaction [Alloxan results in decreased expression of CAT protein]; Chromium inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Alloxan results in decreased expression of CAT protein]
Plant Oils inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Alloxan results in decreased activity of CAT protein]		 CTD PMID:10871429 PMID:19393637 PMID:19693677 PMID:21982801 PMID:24946265 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [Cathelicidins results in increased expression of CCL2 protein]] CTD PMID:18949387 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions
decreases expression		 ISO imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein] CTD PMID:28483572 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization		 ISO Taurine inhibits the reaction [Alloxan affects the localization of CYCS protein] CTD PMID:22138235 PMID:23092809 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Alloxan results in increased expression of DDIT3 mRNA; Alloxan results in increased expression of DDIT3 protein CTD PMID:30076216 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions
decreases expression		 EXP platycodin D inhibits the reaction [Alloxan results in decreased expression of FOXP3 protein] CTD PMID:25887267 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases activity
multiple interactions		 ISO Alloxan results in increased activity of G6PC1 protein
Sodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC1 protein]		 CTD PMID:25779343 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G Gck glucokinase multiple interactions
decreases expression		 EXP
ISO		 Glucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCK protein]
Alloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK protein]		 CTD PMID:12137914 PMID:26827782 PMID:33359794 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gckr glucokinase regulatory protein decreases expression
multiple interactions		 EXP Alloxan results in decreased expression of GCKR protein
Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCKR protein]		 CTD PMID:26827782 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression		 ISO ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]
Alloxan results in decreased expression of GCLC mRNA; Alloxan results in decreased expression of GCLC protein		 CTD PMID:33359794 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO [Alloxan results in increased susceptibility to titanium dioxide] which results in increased activity of GPT protein CTD PMID:23873220 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions
decreases activity		 ISO D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of GSR protein] CTD PMID:21982801 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression		 ISO ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]
Alloxan results in decreased expression of HMOX1 mRNA; Alloxan results in decreased expression of HMOX1 protein		 CTD PMID:33359794 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa5 heat shock protein 5 increases expression EXP Alloxan results in increased expression of HSPA5 mRNA CTD PMID:30076216 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [Cathelicidins results in increased expression of ICAM1 protein]] CTD PMID:18949387 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Alloxan results in decreased expression of and results in decreased secretion of IL10 protein; platycodin D inhibits the reaction [Alloxan results in decreased expression of and results in decreased secretion of IL10 protein] CTD PMID:25887267 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b decreases expression EXP Alloxan results in decreased expression of IL12B protein CTD PMID:16249388 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Alloxan results in increased expression of and results in increased secretion of IL17A protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:25887267 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Alloxan results in increased expression of and results in increased secretion of IL1B protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:25887267 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 Taurine inhibits the reaction [Alloxan results in increased expression of IL6 protein]
Alloxan results in increased expression of and results in increased secretion of IL6 protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]		 CTD PMID:22138235 PMID:25887267 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions
decreases expression
decreases secretion		 EXP
ISO		 Plant Oils inhibits the reaction [Alloxan results in decreased expression of INS1 protein]
Alloxan results in decreased secretion of INS1 protein
[Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [Sertraline binds to 2-Hydroxypropyl-beta-cyclodextrin] inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; Plant Preparations inhibits the reaction [Alloxan results in decreased secretion of INS1 protein]; Sertraline inhibits the reaction [Alloxan results in decreased expression of INS1 protein]		 CTD PMID:19393637 PMID:21050842 PMID:21982801 PMID:26593071 PMID:27317948 More... NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Insr insulin receptor decreases phosphorylation
multiple interactions		 ISO Alloxan results in decreased phosphorylation of INSR protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein]		 CTD PMID:22138235 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
affects phosphorylation		 ISO
EXP		 Alloxan results in decreased phosphorylation of IRS1 protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]
Alloxan affects the phosphorylation of IRS1 protein
Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]		 CTD PMID:22138235 PMID:26827782 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Alloxan results in increased phosphorylation of MAPK1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK1 protein]		 CTD PMID:33359794 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Alloxan results in increased phosphorylation of MAPK3 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK3 protein]		 CTD PMID:33359794 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions
decreases expression		 ISO imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein] CTD PMID:28483572 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions		 ISO Alloxan results in increased activity of MPO protein
Taurine inhibits the reaction [Alloxan results in increased activity of MPO protein]		 CTD PMID:22138235 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of NDUFA9 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of NDUFA9 protein]		 CTD PMID:28483572 NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
decreases expression		 ISO Alloxan affects the localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]]		 CTD PMID:33359794 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal decreases expression EXP Alloxan results in decreased expression of NOS1 mRNA CTD PMID:30076216 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression EXP Alloxan results in increased expression of NOS2 mRNA CTD PMID:30076216 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of NQO1 mRNA; Alloxan results in decreased expression of NQO1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]]		 CTD PMID:33359794 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO Alloxan affects the reaction [imisopasem manganese results in increased expression of NRF1 protein] CTD PMID:28483572 NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases degradation
multiple interactions		 ISO Alloxan results in increased degradation of PARP1 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased degradation of PARP1 protein]		 CTD PMID:21982801 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of PDX1 mRNA; Alloxan results in decreased expression of PDX1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 protein]		 CTD PMID:33359794 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of PPARGC1A protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein]		 CTD PMID:28483572 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases expression		 ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Alloxan results in increased expression of RELA protein
Taurine inhibits the reaction [Alloxan results in increased expression of RELA protein]		 CTD PMID:19020780 PMID:22138235 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rorc RAR-related orphan receptor gamma increases expression
multiple interactions		 EXP Alloxan results in increased expression of RORC protein
platycodin D inhibits the reaction [Alloxan results in increased expression of RORC protein]		 CTD PMID:25887267 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583 		JBrowse link
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) decreases expression
multiple interactions		 ISO Alloxan results in decreased expression of SDHA protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein]		 CTD PMID:28483572 NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 decreases expression
multiple interactions		 EXP
ISO		 Alloxan results in decreased expression of SLC2A2 mRNA
Glucose inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]
Alloxan results in decreased expression of SLC2A2 mRNA; Alloxan results in decreased expression of SLC2A2 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 protein]		 CTD PMID:12137914 PMID:33359794 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 affects localization
multiple interactions
decreases expression		 ISO
EXP		 Alloxan affects the localization of SLC2A4 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]; Taurine inhibits the reaction [Alloxan affects the localization of SLC2A4 protein]
Quercetin inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]		 CTD PMID:22138235 PMID:24946265 PMID:28483572 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Sod1 superoxide dismutase 1, soluble affects response to substance
multiple interactions
decreases activity		 EXP
ISO		 SOD1 protein affects the susceptibility to Alloxan
Sulfur Dioxide inhibits the reaction [Alloxan results in decreased activity of SOD1 protein]		 CTD PMID:10871429 PMID:18502742 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Taurine inhibits the reaction [Alloxan results in increased expression of TNF protein]
Alloxan results in increased expression of and results in increased secretion of TNF protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]		 CTD PMID:19020780 PMID:22138235 PMID:25887267 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression EXP Alloxan results in increased expression of TRPM7 mRNA; Alloxan results in increased expression of TRPM7 protein CTD PMID:30076216 NCBI chr 2:126,633,478...126,718,181
Ensembl chr 2:126,633,485...126,718,150 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 multiple interactions
increases expression		 ISO imisopasem manganese promotes the reaction [Alloxan results in increased expression of UQCRC2 protein] CTD PMID:28483572 NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747 		JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions		 ISO Alloxan results in increased activity of XDH protein
Taurine inhibits the reaction [Alloxan results in increased activity of XDH protein]		 CTD PMID:22138235 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        xenobiotic 19686
          barbituric acid 67
            alloxan 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic molecule 21662
                              organic cyclic compound 21269
                                organic heterocyclic compound 20342
                                  organic heteromonocyclic compound 18757
                                    diazines 13460
                                      pyrimidines 13324
                                        pyrimidone 10535
                                          barbiturates 4775
                                            barbituric acid 67
                                              alloxan 59
paths to the root