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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alloxan
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Accession:CHEBI:76451 term browser browse the term
Definition:A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Synonyms:exact_synonym: pyrimidine-2,4,5,6(1H,3H)-tetrone
 related_synonym: 2,4,5,6(1H,3H)-Pyrimidinetetrone;   2,4,5,6-Tetraoxohexahydropyrimidine;   2,4,5,6-pyrimidinetetrone;   5,6-dioxouracil;   5-oxobarbituric acid;   Alloxane;   Formula=C4H2N2O4;   InChI=1S/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10);   InChIKey=HIMXGTXNXJYFGB-UHFFFAOYSA-N;   Mesoxalylcarbamide;   Mesoxalylurea;   NSC 7169;   Pyrimidinetetrone;   SMILES=O=C1NC(=O)C(=O)C(=O)N1
 xref: CAS:50-71-5;   HMDB:HMDB0002818
 xref_mesh: MESH:D000496
 xref: MetaCyc:CPD-3684;   PDBeChem:LXN;   PMID:21344938;   PMID:23408741;   PMID:23473942;   PMID:23658878;   PMID:23667864;   PMID:23762986;   PMID:24129090;   PMID:24374440;   Reaxys:132451;   Wikipedia:Alloxan


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alloxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases activity
EXP Chromium inhibits the reaction [Alloxan results in increased activity of ACOX1 protein]; chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Actb actin, beta decreases expression ISO Alloxan results in decreased expression of ACTB mRNA CTD PMID:12137914 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Alloxan results in decreased phosphorylation of AKT1 protein
Phycocyanin inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
CTD PMID:26827782 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
increases expression
multiple interactions
EXP Alloxan results in decreased expression of APAF1 protein
Alloxan results in increased expression of APAF1 protein
Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]
CTD PMID:21982801, PMID:23092809 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of ATP2A1 protein] CTD PMID:28483572 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Alloxan results in decreased expression of ATP2A2 protein CTD PMID:28483572 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
EXP Alloxan results in increased expression of BAD protein
Taurine inhibits the reaction [Alloxan results in increased expression of BAD protein]
CTD PMID:22138235 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Taurine inhibits the reaction [Alloxan results in increased expression of BAX protein] CTD PMID:21982801, PMID:22138235, PMID:23092809 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Alloxan results in decreased expression of BCL2 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2 protein]
CTD PMID:21982801, PMID:22138235, PMID:23092809 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of BCL2L1 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2L1 protein]
CTD PMID:22138235 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP3 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP3 protein modified form] CTD PMID:21982801, PMID:22138235, PMID:23092809 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases expression
EXP Alloxan results in increased activity of CASP9 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP9 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein modified form]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein]
Alloxan results in increased expression of CASP9 protein; Alloxan results in increased expression of CASP9 protein modified form
CTD PMID:21982801, PMID:22138235, PMID:23092809 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
EXP
ISO
3,4-dihydroxyphenylethanol inhibits the reaction [Alloxan results in decreased expression of CAT protein]; Chromium inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Alloxan results in decreased expression of CAT protein]
Plant Oils inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Alloxan results in decreased activity of CAT protein]
CTD PMID:10871429, PMID:19393637, PMID:19693677, PMID:21982801, PMID:24946265, PMID:28419827 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [CAP18 lipopolysaccharide-binding protein results in increased expression of CCL2 protein]] CTD PMID:18949387 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein] CTD PMID:28483572 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
EXP Taurine inhibits the reaction [Alloxan affects the localization of CYCS protein] CTD PMID:22138235, PMID:23092809 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Alloxan results in increased expression of DDIT3 mRNA; Alloxan results in increased expression of DDIT3 protein CTD PMID:30076216 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions
ISO Alloxan results in decreased expression of FOXP3 protein
platycodin D inhibits the reaction [Alloxan results in decreased expression of FOXP3 protein]
CTD PMID:25887267 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit increases activity
multiple interactions
EXP Alloxan results in increased activity of G6PC protein
Sodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC protein]
CTD PMID:25779343 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gck glucokinase multiple interactions
decreases expression
ISO Glucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCK protein]
Alloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK protein
CTD PMID:12137914, PMID:26827782 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gckr glucokinase regulator decreases expression
multiple interactions
ISO Alloxan results in decreased expression of GCKR protein
Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCKR protein]
CTD PMID:26827782 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Alloxan results in increased susceptibility to titanium dioxide] which results in increased activity of GPT protein CTD PMID:23873220 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of GSR protein] CTD PMID:21982801 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Alloxan results in increased expression of HSPA5 mRNA CTD PMID:30076216 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [CAP18 lipopolysaccharide-binding protein results in increased expression of ICAM1 protein]] CTD PMID:18949387 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Alloxan results in decreased expression of and results in decreased secretion of IL10 protein; platycodin D inhibits the reaction [Alloxan results in decreased expression of and results in decreased secretion of IL10 protein] CTD PMID:25887267 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases expression ISO Alloxan results in decreased expression of IL12B protein CTD PMID:16249388 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL17A protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:25887267 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL1B protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:25887267 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Taurine inhibits the reaction [Alloxan results in increased expression of IL6 protein]
Alloxan results in increased expression of and results in increased secretion of IL6 protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]
CTD PMID:22138235, PMID:25887267 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor decreases phosphorylation
multiple interactions
EXP Alloxan results in decreased phosphorylation of INSR protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein]
CTD PMID:22138235 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
affects phosphorylation
EXP
ISO
Alloxan results in decreased phosphorylation of IRS1 protein
Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]
CTD PMID:22138235, PMID:26827782 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of MFN2 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein]
CTD PMID:28483572 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
EXP Alloxan results in increased activity of MPO protein
Taurine inhibits the reaction [Alloxan results in increased activity of MPO protein]
CTD PMID:22138235 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of NDUFA9 protein] CTD PMID:28483572 NCBI chr 4:159,371,263...159,399,636
Ensembl chr 4:159,371,259...159,399,634
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression ISO Alloxan results in decreased expression of NOS1 mRNA CTD PMID:30076216 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Alloxan results in increased expression of NOS2 mRNA CTD PMID:30076216 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Alloxan affects the reaction [imisopasem manganese results in increased expression of NRF1 protein] CTD PMID:28483572 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions
EXP Alloxan results in increased degradation of PARP1 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased degradation of PARP1 protein]
CTD PMID:21982801 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein] CTD PMID:28483572 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO
EXP
Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Taurine inhibits the reaction [Alloxan results in increased expression of RELA protein]
CTD PMID:19020780, PMID:22138235 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO Alloxan results in increased expression of RORC protein
platycodin D inhibits the reaction [Alloxan results in increased expression of RORC protein]
CTD PMID:25887267 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein] CTD PMID:28483572 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression
multiple interactions
ISO Alloxan results in decreased expression of SLC2A2 mRNA
Glucose inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]
CTD PMID:12137914 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
decreases expression
multiple interactions
EXP
ISO
Alloxan affects the localization of SLC2A4 protein
Alloxan results in decreased expression of SLC2A4 protein
Quercetin inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]; Taurine inhibits the reaction [Alloxan affects the localization of SLC2A4 protein]
CTD PMID:22138235, PMID:24946265, PMID:28483572 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod1 superoxide dismutase 1 affects response to substance
decreases activity
multiple interactions
ISO
EXP
SOD1 protein affects the susceptibility to Alloxan
Alloxan results in decreased activity of SOD1 protein
Sulfur Dioxide inhibits the reaction [Alloxan results in decreased activity of SOD1 protein]
CTD PMID:10871429, PMID:18502742 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Alloxan results in increased expression of and results in increased secretion of TNF protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]
Alloxan results in increased expression of TNF protein
Taurine inhibits the reaction [Alloxan results in increased expression of TNF protein]
CTD PMID:19020780, PMID:22138235, PMID:25887267 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO Alloxan results in increased expression of TRPM7 mRNA; Alloxan results in increased expression of TRPM7 protein CTD PMID:30076216 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 increases expression
multiple interactions
EXP Alloxan results in increased expression of UQCRC2 protein
imisopasem manganese promotes the reaction [Alloxan results in increased expression of UQCRC2 protein]
CTD PMID:28483572 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions
EXP Alloxan results in increased activity of XDH protein
Taurine inhibits the reaction [Alloxan results in increased activity of XDH protein]
CTD PMID:22138235 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        xenobiotic 18380
          barbituric acid 60
            alloxan 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    diazines 12138
                                      pyrimidines 11955
                                        pyrimidone 8749
                                          barbiturates 4378
                                            barbituric acid 60
                                              alloxan 50
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.