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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alloxan
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Accession:CHEBI:76451 term browser browse the term
Definition:A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Synonyms:exact_synonym: pyrimidine-2,4,5,6(1H,3H)-tetrone
 related_synonym: 2,4,5,6(1H,3H)-Pyrimidinetetrone;   2,4,5,6-Tetraoxohexahydropyrimidine;   2,4,5,6-pyrimidinetetrone;   5,6-dioxouracil;   5-oxobarbituric acid;   Alloxane;   Formula=C4H2N2O4;   InChI=1S/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10);   InChIKey=HIMXGTXNXJYFGB-UHFFFAOYSA-N;   Mesoxalylcarbamide;   Mesoxalylurea;   NSC 7169;   Pyrimidinetetrone;   SMILES=O=C1NC(=O)C(=O)C(=O)N1
 xref: CAS:50-71-5;   HMDB:HMDB0002818
 xref_mesh: MESH:D000496
 xref: MetaCyc:CPD-3684;   PDBeChem:LXN;   PMID:21344938;   PMID:23408741;   PMID:23473942;   PMID:23658878;   PMID:23667864;   PMID:23762986;   PMID:24129090;   PMID:24374440;   Reaxys:132451;   Wikipedia:Alloxan


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alloxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases activity
EXP Chromium inhibits the reaction [Alloxan results in increased activity of ACOX1 protein]; chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Actb actin, beta decreases expression ISO Alloxan results in decreased expression of ACTB mRNA CTD PMID:12137914 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
Alloxan results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
Phycocyanin inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
CTD PMID:26827782 PMID:33359794 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
increases expression
multiple interactions
EXP Alloxan results in decreased expression of APAF1 protein
Alloxan results in increased expression of APAF1 protein
Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]
CTD PMID:21982801 PMID:23092809 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of ATP2A1 protein] CTD PMID:28483572 NCBI chr 1:181,026,606...181,044,859 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Alloxan results in decreased expression of ATP2A2 protein CTD PMID:28483572 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
EXP Alloxan results in increased expression of BAD protein
Taurine inhibits the reaction [Alloxan results in increased expression of BAD protein]
CTD PMID:22138235 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Taurine inhibits the reaction [Alloxan results in increased expression of BAX protein] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Alloxan results in decreased expression of BCL2 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2 protein]
CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of BCL2L1 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2L1 protein]
CTD PMID:22138235 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP3 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP3 protein modified form] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases expression
EXP Alloxan results in increased activity of CASP9 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP9 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein modified form]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein]
Alloxan results in increased expression of CASP9 protein; Alloxan results in increased expression of CASP9 protein modified form
CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
EXP
ISO
3,4-dihydroxyphenylethanol inhibits the reaction [Alloxan results in decreased expression of CAT protein]; Chromium inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Alloxan results in decreased expression of CAT protein]
Plant Oils inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Alloxan results in decreased activity of CAT protein]
CTD PMID:10871429 PMID:19393637 PMID:19693677 PMID:21982801 PMID:24946265 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [ropocamptide results in increased expression of CCL2 protein]] CTD PMID:18949387 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein] CTD PMID:28483572 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
EXP Taurine inhibits the reaction [Alloxan affects the localization of CYCS protein] CTD PMID:22138235 PMID:23092809 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Alloxan results in increased expression of DDIT3 mRNA; Alloxan results in increased expression of DDIT3 protein CTD PMID:30076216 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions
ISO Alloxan results in decreased expression of FOXP3 protein
platycodin D inhibits the reaction [Alloxan results in decreased expression of FOXP3 protein]
CTD PMID:25887267 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases activity
multiple interactions
EXP Alloxan results in increased activity of G6PC1 protein
Sodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC1 protein]
CTD PMID:25779343 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gck glucokinase multiple interactions
decreases expression
ISO
EXP
Glucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCK protein]
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK protein]
Alloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK protein
CTD PMID:12137914 PMID:26827782 PMID:33359794 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gckr glucokinase regulator decreases expression
multiple interactions
ISO Alloxan results in decreased expression of GCKR protein
Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCKR protein]
CTD PMID:26827782 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions
EXP Alloxan results in decreased expression of GCLC mRNA; Alloxan results in decreased expression of GCLC protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]
CTD PMID:33359794 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Alloxan results in increased susceptibility to titanium dioxide] which results in increased activity of GPT protein CTD PMID:23873220 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of GSR protein] CTD PMID:21982801 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of HMOX1 mRNA; Alloxan results in decreased expression of HMOX1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]
CTD PMID:33359794 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Alloxan results in increased expression of HSPA5 mRNA CTD PMID:30076216 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [ropocamptide results in increased expression of ICAM1 protein]] CTD PMID:18949387 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Alloxan results in decreased expression of and results in decreased secretion of IL10 protein; platycodin D inhibits the reaction [Alloxan results in decreased expression of and results in decreased secretion of IL10 protein] CTD PMID:25887267 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B decreases expression ISO Alloxan results in decreased expression of IL12B protein CTD PMID:16249388 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL17A protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:25887267 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL1B protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:25887267 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Taurine inhibits the reaction [Alloxan results in increased expression of IL6 protein]
Alloxan results in increased expression of and results in increased secretion of IL6 protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]
CTD PMID:22138235 PMID:25887267 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor decreases phosphorylation
multiple interactions
EXP Alloxan results in decreased phosphorylation of INSR protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein]
CTD PMID:22138235 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
affects phosphorylation
EXP
ISO
Alloxan results in decreased phosphorylation of IRS1 protein
Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]
CTD PMID:22138235 PMID:26827782 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Alloxan results in increased phosphorylation of MAPK1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK1 protein]
CTD PMID:33359794 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK3 protein] CTD PMID:33359794 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of MFN2 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein]
CTD PMID:28483572 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
EXP Alloxan results in increased activity of MPO protein
Taurine inhibits the reaction [Alloxan results in increased activity of MPO protein]
CTD PMID:22138235 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of NDUFA9 protein] CTD PMID:28483572 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
affects localization
EXP Alloxan results in decreased expression of NFE2L2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]]
CTD PMID:33359794 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression ISO Alloxan results in decreased expression of NOS1 mRNA CTD PMID:30076216 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Alloxan results in increased expression of NOS2 mRNA CTD PMID:30076216 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP Alloxan results in decreased expression of NQO1 mRNA; Alloxan results in decreased expression of NQO1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]]
CTD PMID:33359794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Alloxan affects the reaction [imisopasem manganese results in increased expression of NRF1 protein] CTD PMID:28483572 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions
EXP Alloxan results in increased degradation of PARP1 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased degradation of PARP1 protein]
CTD PMID:21982801 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
decreases expression
EXP ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 protein]
Alloxan results in decreased expression of PDX1 mRNA; Alloxan results in decreased expression of PDX1 protein
CTD PMID:33359794 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein] CTD PMID:28483572 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO
EXP
Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Taurine inhibits the reaction [Alloxan results in increased expression of RELA protein]
CTD PMID:19020780 PMID:22138235 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO Alloxan results in increased expression of RORC protein
platycodin D inhibits the reaction [Alloxan results in increased expression of RORC protein]
CTD PMID:25887267 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein] CTD PMID:28483572 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression
multiple interactions
ISO
EXP
Alloxan results in decreased expression of SLC2A2 mRNA
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 protein]
Alloxan results in decreased expression of SLC2A2 mRNA; Alloxan results in decreased expression of SLC2A2 protein
Glucose inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]
CTD PMID:12137914 PMID:33359794 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
decreases expression
multiple interactions
EXP
ISO
Alloxan affects the localization of SLC2A4 protein
Alloxan results in decreased expression of SLC2A4 protein
Quercetin inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]; Taurine inhibits the reaction [Alloxan affects the localization of SLC2A4 protein]
CTD PMID:22138235 PMID:24946265 PMID:28483572 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sod1 superoxide dismutase 1 affects response to substance
decreases activity
multiple interactions
ISO
EXP
SOD1 protein affects the susceptibility to Alloxan
Alloxan results in decreased activity of SOD1 protein
Sulfur Dioxide inhibits the reaction [Alloxan results in decreased activity of SOD1 protein]
CTD PMID:10871429 PMID:18502742 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Alloxan results in increased expression of and results in increased secretion of TNF protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]
Alloxan results in increased expression of TNF protein
Taurine inhibits the reaction [Alloxan results in increased expression of TNF protein]
CTD PMID:19020780 PMID:22138235 PMID:25887267 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO Alloxan results in increased expression of TRPM7 mRNA; Alloxan results in increased expression of TRPM7 protein CTD PMID:30076216 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 increases expression
multiple interactions
EXP Alloxan results in increased expression of UQCRC2 protein
imisopasem manganese promotes the reaction [Alloxan results in increased expression of UQCRC2 protein]
CTD PMID:28483572 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions
EXP Alloxan results in increased activity of XDH protein
Taurine inhibits the reaction [Alloxan results in increased activity of XDH protein]
CTD PMID:22138235 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        xenobiotic 18442
          barbituric acid 66
            alloxan 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteromonocyclic compound 17081
                                    diazines 12328
                                      pyrimidines 12157
                                        pyrimidone 8856
                                          barbiturates 4393
                                            barbituric acid 66
                                              alloxan 57
paths to the root