quercetin O-glycoside - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	quercetin O-glycoside	go back to main search page
Accession:	CHEBI:76424	browse the term
Definition:	Any glycosyloxyflavone that is an O-glycosylated derivative of quercetin.
Synonyms:	related_synonym:	quercetin O-glycosides

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Rat (466) Mouse (465) Human (473) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (466)

miquelianin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase medium chain

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

adrenoceptor beta 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

angiotensinogen

multiple interactions

quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

arachidonate 5-lipoxygenase

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

amyloid beta precursor protein

multiple interactions
decreases expression

quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form]
quercetin 3-O-glucuronide results in decreased expression of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

catalase

multiple interactions

[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CD36 molecule

decreases expression

quercetin 3-O-glucuronide results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

carnitine palmitoyltransferase 1A

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

Fas cell surface death receptor

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

heme oxygenase 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein

PMID:24929186 PMID:25716194

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor substrate 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

matrix metallopeptidase 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

macrophage scavenger receptor 1

decreases expression

quercetin 3-O-glucuronide results in decreased expression of MSR1 mRNA

NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676

G

nitric oxide synthase 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

peroxisome proliferator activated receptor alpha

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

quercetin 3-O-glucuronide results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 8

multiple interactions
increases uptake

quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]
SLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

sterol regulatory element binding transcription factor 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

tumor necrosis factor

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of TNF protein]
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein]

PMID:17880982 PMID:23504962 PMID:26190035

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

decreases activity

quercetin 3-O-glucuronide results in decreased activity of TNFSF11 protein

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

vascular cell adhesion molecule 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

quercetin 3-O-beta-D-galactopyranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases expression
multiple interactions

hyperoside results in increased expression of ACHE mRNA
hyperoside results in increased expression of and results in increased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

BCL2 associated X, apoptosis regulator

multiple interactions

hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of BAX protein]
hyperoside inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]

PMID:18552516 PMID:31326407

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 5

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of BIRC5 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions

[Quercetin co-treated with hyperoside] results in increased cleavage of CASP3 protein

PMID:24173369 PMID:25354548

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

cyclopamine inhibits the reaction [hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]; hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome c, somatic

multiple interactions

hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions

hyperoside results in decreased activity of CYP2E1 protein
hyperoside inhibits the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

estrogen receptor 1

multiple interactions

hyperoside inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

GLI family zinc finger 1

multiple interactions
increases expression

hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 protein]
hyperoside results in increased expression of GLI1 mRNA; hyperoside results in increased expression of GLI1 protein

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glutamic--pyruvic transaminase

multiple interactions

hyperoside inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

mitogen activated protein kinase 1

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 21

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of MIR21 mRNA; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]; MIR21 mRNA results in decreased susceptibility to [Quercetin co-treated with hyperoside]

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 27a

multiple interactions

[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in decreased expression of ZBTB10 mRNA]; [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]; [Quercetin co-treated with hyperoside] results in decreased expression of MIR27A mRNA; MIR27A mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA]

NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917

G

NFE2 like bZIP transcription factor 2

affects localization

hyperoside affects the localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NAD(P)H quinone dehydrogenase 1

increases expression

Hyperoside increases expression of Nqo1 protein in liver

RGD

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Quercetin co-treated with hyperoside] results in increased cleavage of PARP1 protein

PMID:24173369 PMID:25354548

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 4

multiple interactions

[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA; [Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

proline rich membrane anchor 1

increases expression

hyperoside results in increased expression of PRIMA1 mRNA

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sonic hedgehog signaling molecule

increases expression
multiple interactions

hyperoside results in increased expression of SHH mRNA; hyperoside results in increased expression of SHH protein
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SHH mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SHH protein]

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

sirtuin 1

multiple interactions

hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 2 member 2

increases expression

hyperoside analog results in increased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 5 member 1

increases expression

hyperoside analog results in increased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

smoothened, frizzled class receptor

increases expression
multiple interactions

hyperoside results in increased expression of SMO mRNA; hyperoside results in increased expression of SMO protein
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein]

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

Sp1 transcription factor

multiple interactions

[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]; [Quercetin co-treated with hyperoside] results in decreased expression of SP1 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP1 protein

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

Sp3 transcription factor

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP3 protein

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

Sp4 transcription factor

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of SP4 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP4 protein

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

G

sulfotransferase family 2A member 1

multiple interactions
increases expression

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of SULT2A1 mRNA]
hyperoside results in increased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

tumor necrosis factor

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
increases expression

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]
hyperoside results in increased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A6 mRNA]

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions
increases expression

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT2B1 mRNA]
hyperoside results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

vascular cell adhesion molecule 1

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

zinc finger and BTB domain containing 10

multiple interactions

[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in decreased expression of ZBTB10 mRNA]; [Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA; MIR27A mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA]

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

quercetin 3-O-beta-D-glucofuranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

aldo-keto reductase family 7 member A3

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

apolipoprotein A1

increases secretion

isoquercitrin results in increased secretion of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

activating transcription factor 6

increases expression

isoquercitrin results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ataxin 2

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 3

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2, apoptosis regulator

decreases expression

isoquercitrin results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

affects expression

isoquercitrin affects the expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases expression

isoquercitrin results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of CAT mRNA; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:30298849 PMID:30817903

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

catenin beta 1

affects expression

isoquercitrin affects the expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA
isoquercitrin results in decreased activity of CYP1A1 protein

PMID:16271822 PMID:20033131

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

isoquercitrin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 51

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of CYP51A1 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

7-dehydrocholesterol reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

epidermal growth factor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

farnesyl diphosphate farnesyl transferase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutathione peroxidase 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of GRIA3 mRNA]

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutathione S-transferase alpha 5

multiple interactions

[isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

multiple interactions

isoquercitrin inhibits the reaction [beta-Naphthoflavone results in increased expression of HMOX1 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]

PMID:21295105 PMID:30817903

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

integrin-binding sialoprotein

increases expression

isoquercitrin results in increased expression of IBSP mRNA

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interleukin 1 alpha

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in increased expression of IL1A mRNA; [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA

PMID:21295105 PMID:31068541

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

Janus kinase 1

increases expression

isoquercitrin results in increased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

increases expression

isoquercitrin results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lactase

multiple interactions

[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

low density lipoprotein receptor

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

affects expression

isoquercitrin affects the expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

malic enzyme 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

matrix metallopeptidase 2

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

NFE2 like bZIP transcription factor 2

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]

PMID:20033131 PMID:31068541

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neuronal vesicle trafficking associated 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

orthodenticle homeobox 2

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

Parkinsonism associated deglycase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

affects expression

isoquercitrin affects the expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

isoquercitrin results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peptidylprolyl isomerase D

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prostaglandin-endoperoxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA]

PMID:14654164 PMID:20045035 PMID:30817903

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RELB proto-oncogene, NF-kB subunit

increases expression

isoquercitrin results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

RUNX family transcription factor 2

increases expression

isoquercitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sterol-C5-desaturase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

serpin family E member 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 5 member 1

multiple interactions

isoquercitrin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

squalene epoxidase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein; [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA; SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

increases expression

isoquercitrin results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 6

increases expression

isoquercitrin results in increased expression of STAT6 mRNA

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

STIP1 homology and U-box containing protein 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA]

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

tyrosine hydroxylase

multiple interactions

isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

increases expression

isoquercitrin results in increased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNF mRNA]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]

PMID:14654164 PMID:21295105 PMID:30817903

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRADD protein]

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

thioredoxin 1

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

tyrosine kinase 2

affects expression

isoquercitrin affects the expression of TYK2 mRNA

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

G

ubiquitin C-terminal hydrolase L1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

quercetin 3-O-beta-D-glucopyranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

aldo-keto reductase family 7 member A3

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

apolipoprotein A1

increases secretion

isoquercitrin results in increased secretion of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

activating transcription factor 6

increases expression

isoquercitrin results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ataxin 2

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 3

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2, apoptosis regulator

decreases expression

isoquercitrin results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

affects expression

isoquercitrin affects the expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases expression

isoquercitrin results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of CAT mRNA; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:30298849 PMID:30817903

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

catenin beta 1

affects expression

isoquercitrin affects the expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
multiple interactions

isoquercitrin results in decreased activity of CYP1A1 protein
[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA

PMID:16271822 PMID:20033131

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

isoquercitrin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 51

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of CYP51A1 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

7-dehydrocholesterol reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

epidermal growth factor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

farnesyl diphosphate farnesyl transferase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutathione peroxidase 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of GRIA3 mRNA]

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutathione S-transferase alpha 5

multiple interactions

[isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

multiple interactions

isoquercitrin inhibits the reaction [beta-Naphthoflavone results in increased expression of HMOX1 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]

PMID:21295105 PMID:30817903

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

integrin-binding sialoprotein

increases expression

isoquercitrin results in increased expression of IBSP mRNA

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interleukin 1 alpha

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in increased expression of IL1A mRNA; [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA

PMID:21295105 PMID:31068541

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

Janus kinase 1

increases expression

isoquercitrin results in increased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

increases expression

isoquercitrin results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lactase

multiple interactions

[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

low density lipoprotein receptor

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

affects expression

isoquercitrin affects the expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

malic enzyme 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

matrix metallopeptidase 2

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

NFE2 like bZIP transcription factor 2

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]

PMID:20033131 PMID:31068541

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neuronal vesicle trafficking associated 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

orthodenticle homeobox 2

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

Parkinsonism associated deglycase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

affects expression

isoquercitrin affects the expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

isoquercitrin results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peptidylprolyl isomerase D

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prostaglandin-endoperoxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA]

PMID:14654164 PMID:20045035 PMID:30817903

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RELB proto-oncogene, NF-kB subunit

increases expression

isoquercitrin results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

RUNX family transcription factor 2

increases expression

isoquercitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sterol-C5-desaturase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

serpin family E member 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 5 member 1

multiple interactions

isoquercitrin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

squalene epoxidase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein; [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA; SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

increases expression

isoquercitrin results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 6

increases expression

isoquercitrin results in increased expression of STAT6 mRNA

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

STIP1 homology and U-box containing protein 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA]

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

tyrosine hydroxylase

multiple interactions

isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

increases expression

isoquercitrin results in increased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNF mRNA]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]

PMID:14654164 PMID:21295105 PMID:30817903

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRADD protein]

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

thioredoxin 1

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

tyrosine kinase 2

affects expression

isoquercitrin affects the expression of TYK2 mRNA

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

G

ubiquitin C-terminal hydrolase L1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

quercetin 4'-O-beta-D-glucopyranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

adaptor related protein complex 5 subunit mu 1

decreases expression

spiraeoside results in decreased expression of AP5M1 protein

NCBI chr15:22,355,478...22,385,222
Ensembl chr15:22,355,500...22,377,750

G

BCL2 associated X, apoptosis regulator

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
spiraeoside results in decreased expression of BCL2 protein

PMID:32602595 PMID:34116102

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BH3 interacting domain death agonist

decreases expression

spiraeoside results in decreased expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

decreases expression

spiraeoside results in decreased expression of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

decreases expression

spiraeoside results in decreased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]]; spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin dependent kinase 2

decreases expression

spiraeoside results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

crystallin zeta

increases activity

spiraeoside results in increased activity of CRYZ protein

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

heme oxygenase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

lactase

multiple interactions

[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

NFE2 like bZIP transcription factor 2

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

phospholipase C, gamma 2

decreases phosphorylation

spiraeoside results in decreased phosphorylation of PLCG2 protein

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

solute carrier family 5 member 1

multiple interactions

[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeoside
spiraeoside inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

PMID:12663055 PMID:17495124

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

spleen associated tyrosine kinase

decreases phosphorylation

spiraeoside results in decreased phosphorylation of SYK protein

NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410

quercitrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 4

decreases expression

quercitrin results in decreased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily F member 2

increases expression

quercitrin results in increased expression of ABCF2 mRNA

NCBI chr 4:10,594,802...10,607,620
Ensembl chr 4:10,594,907...10,607,606

G

acyl-CoA binding domain containing 6

decreases expression

quercitrin results in decreased expression of ACBD6 mRNA

NCBI chr13:67,726,786...67,863,392
Ensembl chr13:67,726,786...67,862,311

G

acyl-CoA binding domain containing 7

increases expression

quercitrin results in increased expression of ACBD7 mRNA

NCBI chr17:74,903,936...74,909,977
Ensembl chr17:74,903,177...74,905,811

G

actinin, alpha 1

affects expression

quercitrin affects the expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

actinin alpha 4

affects expression

quercitrin affects the expression of ACTN4 mRNA

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

adhesion G protein-coupled receptor B1

decreases expression

quercitrin results in decreased expression of ADGRB1 mRNA

NCBI chr 7:106,404,827...106,476,902
Ensembl chr 7:106,404,958...106,476,902

G

adhesion G protein-coupled receptor F1

decreases expression

quercitrin results in decreased expression of ADGRF1 mRNA

NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704

G

adhesion G protein-coupled receptor G1

decreases expression

quercitrin results in decreased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

adhesion G protein-coupled receptor G6

decreases expression

quercitrin results in decreased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adhesion G protein-coupled receptor G7

increases expression

quercitrin results in increased expression of ADGRG7 mRNA

NCBI chr11:43,808,101...43,877,539
Ensembl chr11:43,813,801...43,876,316

G

adhesion G protein-coupled receptor V1

increases expression

quercitrin results in increased expression of ADGRV1 mRNA

NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688

G

adenosine kinase

decreases expression

quercitrin results in decreased expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adrenoceptor alpha 2C

increases expression

quercitrin results in increased expression of ADRA2C mRNA

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

AHNAK nucleoprotein 2

increases expression

quercitrin results in increased expression of AHNAK2 mRNA

NCBI chr 6:131,830,668...131,876,311

G

alkB homolog 7

increases expression

quercitrin results in increased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

anaphase promoting complex subunit 15

decreases expression

quercitrin results in decreased expression of ANAPC15 mRNA

NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145

G

androgen receptor

increases expression

quercitrin results in increased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

increases expression

quercitrin results in increased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

ankyrin repeat and SOCS box-containing 6

increases expression

quercitrin results in increased expression of ASB6 mRNA

NCBI chr 3:14,110,628...14,115,274
Ensembl chr 3:14,110,628...14,115,242

G

autophagy related 7

decreases expression

quercitrin results in decreased expression of ATG7 mRNA

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

BAR/IMD domain containing adaptor protein 2

affects expression

quercitrin affects the expression of BAIAP2 mRNA

NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134

G

BCL2 associated X, apoptosis regulator

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bradykinin receptor B1

decreases expression

quercitrin results in decreased expression of BDKRB1 mRNA

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

similar to human chromosome 2 open reading frame 49

decreases expression

quercitrin results in decreased expression of C2ORF49 mRNA

NCBI chr 9:45,371,396...45,382,123
Ensembl chr 9:45,371,430...45,382,120

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

quercitrin results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

caspase 3

increases activity
multiple interactions

quercitrin results in increased activity of CASP3 protein
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]

PMID:23138875 PMID:25193878

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases expression

quercitrin results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine receptor 9

decreases expression

quercitrin results in decreased expression of CCR9 mRNA

NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969

G

C-C motif chemokine receptor like 2

increases expression

quercitrin results in increased expression of CCRL2 mRNA

NCBI chr 8:111,034,279...111,036,914
Ensembl chr 8:111,034,279...111,036,664

G

CD302 molecule

decreases expression

quercitrin results in decreased expression of CD302 mRNA

NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045

G

CD38 molecule

decreases expression

quercitrin results in decreased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD74 molecule

affects expression

quercitrin affects the expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

cadherin 1

decreases expression

quercitrin results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 3

decreases expression

quercitrin results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

quercitrin results in increased expression of CELSR3 mRNA

NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354

G

centrosomal protein 95

increases expression

quercitrin results in increased expression of CEP95 mRNA

NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092

G

ceramide synthase 5

increases expression

quercitrin results in increased expression of CERS5 mRNA

NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947

G

cilia and flagella associated protein 298

decreases expression

quercitrin results in decreased expression of CFAP298 mRNA

NCBI chr11:30,181,916...30,191,302
Ensembl chr11:30,181,905...30,191,346

G

chromodomain helicase DNA binding protein 2

decreases expression

quercitrin results in decreased expression of CHD2 mRNA

NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502

G

claudin 10

affects expression

quercitrin affects the expression of CLDN10 mRNA

NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526

G

claudin 23

affects expression

quercitrin affects the expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

claudin 4

affects expression

quercitrin affects the expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 8

affects expression

quercitrin affects the expression of CLDN8 mRNA

NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513

G

collagen type III alpha 1 chain

decreases expression

quercitrin results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

coenzyme Q3 methyltransferase

decreases expression

quercitrin results in decreased expression of COQ3 mRNA

NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607

G

cysteine-rich secretory protein 1

decreases expression

quercitrin results in decreased expression of CRISP1 mRNA

NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796

G

crystallin zeta like 1

decreases expression

quercitrin results in decreased expression of CRYZL1 mRNA

NCBI chr11:30,933,140...30,977,936
Ensembl chr11:30,933,144...30,977,867

G

casein kinase 2 alpha 1

affects expression

quercitrin affects the expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

casein kinase 2 alpha 2

affects expression

quercitrin affects the expression of CSNK2A2 mRNA

NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080

G

CTD small phosphatase like 2

decreases expression

quercitrin results in decreased expression of CTDSPL2 mRNA

NCBI chr 3:108,915,263...108,970,620
Ensembl chr 3:108,915,280...108,967,227

G

cathepsin B

affects expression

quercitrin affects the expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

quercitrin results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

quercitrin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

quercitrin results in increased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

defective in cullin neddylation 1 domain containing 5

decreases expression

quercitrin results in decreased expression of DCUN1D5 mRNA

NCBI chr 8:4,412,266...4,433,380
Ensembl chr 8:4,412,221...4,433,367

G

DEAD-box helicase 19B

decreases expression

quercitrin results in decreased expression of DDX19B mRNA

NCBI chr19:38,968,215...38,998,907
Ensembl chr19:38,968,215...38,997,259

G

DAP3 binding cell death enhancer 1

decreases expression

quercitrin results in decreased expression of DELE1 mRNA

NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756

G

diacylglycerol kinase, theta

affects expression

quercitrin affects the expression of DGKQ mRNA

NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131

G

dehydrogenase/reductase 11

decreases activity

quercitrin results in decreased activity of DHRS11 protein

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

DTW domain containing 1

decreases expression

quercitrin results in decreased expression of DTWD1 mRNA

NCBI chr 3:113,392,402...113,409,322
Ensembl chr 3:113,392,457...113,408,105

G

estrogen-induced osteoclastogenesis regulator 1

increases expression

quercitrin results in increased expression of EEIG1 mRNA

NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643

G

early growth response 2

increases expression

quercitrin results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

endothelial PAS domain protein 1

increases expression

quercitrin results in increased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

ERCC excision repair 1, endonuclease non-catalytic subunit

decreases expression

quercitrin results in decreased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

quercitrin results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERI1 exoribonuclease family member 2

increases expression

quercitrin results in increased expression of ERI2 mRNA

NCBI chr 1:174,140,831...174,168,757
Ensembl chr 1:174,141,993...174,168,665

G

eva-1 homolog A, regulator of programmed cell death

decreases expression

quercitrin results in decreased expression of EVA1A mRNA

NCBI chr 4:114,593,773...114,643,011
Ensembl chr 4:114,593,341...114,643,011

G

F11 receptor

affects expression

quercitrin affects the expression of F11R mRNA

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

F2R like trypsin receptor 1

increases expression

quercitrin results in increased expression of F2RL1 mRNA

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

quercitrin results in decreased expression of F2RL2 mRNA

NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098

G

coagulation factor III, tissue factor

increases expression

quercitrin results in increased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

Fas apoptotic inhibitory molecule

increases expression

quercitrin results in increased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

family with sequence similarity 216, member A

decreases expression

quercitrin results in decreased expression of FAM216A mRNA

NCBI chr12:34,198,526...34,207,673
Ensembl chr12:34,198,526...34,207,665

G

FAM3 metabolism regulating signaling molecule C

increases expression

quercitrin results in increased expression of FAM3C mRNA

NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078

G

family with sequence similarity 43, member A

increases expression

quercitrin results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

family with sequence similarity 50, member A

increases expression

quercitrin results in increased expression of FAM50A mRNA

NCBI chr X:152,095,245...152,102,362
Ensembl chr X:152,095,245...152,102,362

G

Fas cell surface death receptor

increases expression

quercitrin results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

follicular dendritic cell secreted protein

decreases expression

quercitrin results in decreased expression of FDCSP mRNA

NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983

G

filaggrin

increases expression

quercitrin results in increased expression of FLG mRNA

NCBI chr 2:178,884,793...178,912,986

G

frizzled class receptor 4

increases expression

quercitrin results in increased expression of FZD4 mRNA

NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724

G

gamma-aminobutyric acid type B receptor subunit 2

increases expression

quercitrin results in increased expression of GABBR2 mRNA

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

growth arrest and DNA-damage-inducible, alpha

affects expression

quercitrin affects the expression of GADD45 mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

galactokinase 2

increases expression

quercitrin results in increased expression of GALK2 mRNA

NCBI chr 3:113,110,057...113,243,014
Ensembl chr 3:113,110,030...113,233,306

G

galanin receptor 3

increases expression

quercitrin results in increased expression of GALR3 mRNA

NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685

G

GTPase, IMAP family member 6

increases expression

quercitrin results in increased expression of GIMAP6 mRNA

NCBI chr 4:77,653,703...77,659,112
Ensembl chr 4:77,652,610...77,659,116

G

GLI pathogenesis-related 1

decreases expression

quercitrin results in decreased expression of GLIPR1 mRNA

NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429

G

golgi integral membrane protein 4

increases expression

quercitrin results in increased expression of GOLIM4 mRNA

NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253

G

G protein-coupled receptor 137B

increases expression

quercitrin results in increased expression of GPR137B mRNA

NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835

G

G-protein coupled receptor 173

increases expression

quercitrin results in increased expression of GPR173 mRNA

NCBI chr X:21,446,261...21,471,119
Ensembl chr X:21,447,361...21,471,498

G

G protein-coupled receptor 174

increases expression

quercitrin results in increased expression of GPR174 mRNA

NCBI chr X:72,355,452...72,396,146
Ensembl chr X:72,355,033...72,397,658

G

G protein-coupled receptor 19

increases expression

quercitrin results in increased expression of GPR19 mRNA

NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036

G

G protein-coupled receptor 4

increases expression

quercitrin results in increased expression of GPR4 mRNA

NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599

G

G protein-coupled receptor 63

increases expression

quercitrin results in increased expression of GPR63 mRNA

NCBI chr 5:38,672,548...38,727,224
Ensembl chr 5:38,635,472...38,727,677

G

G protein-coupled receptor 83

increases expression

quercitrin results in increased expression of GPR83 mRNA

NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028

G

glutathione S-transferase pi 1

decreases expression

quercitrin results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hepatitis A virus cellular receptor 2

increases expression

quercitrin results in increased expression of HAVCR2 mRNA

NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137

G

hepatocyte growth factor

increases expression

quercitrin results in increased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

high mobility group AT-hook 2

increases expression

quercitrin results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

high mobility group box 2

decreases expression

quercitrin results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

hepatocyte nuclear factor 4, alpha

decreases expression

quercitrin results in decreased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heat shock protein 90 alpha family class A member 1

affects expression

quercitrin affects the expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 1 like

affects expression

quercitrin affects the expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

affects expression

quercitrin affects the expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

affects expression

quercitrin affects the expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

interferon, alpha 1

affects expression

quercitrin affects the expression of IFNA1 mRNA

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1 receptor

affects expression

quercitrin affects the expression of IGF1R mRNA

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 15

decreases expression

quercitrin results in decreased expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 1 beta

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

INO80 complex subunit C

decreases expression

quercitrin results in decreased expression of INO80C mRNA

NCBI chr18:15,378,764...15,398,574
Ensembl chr18:15,378,770...15,393,403

G

inositol polyphosphate-4-phosphatase type I A

affects expression

quercitrin affects the expression of INPP4A mRNA

NCBI chr 9:39,528,245...39,650,574
Ensembl chr 9:39,528,674...39,646,581

G

inositol polyphosphate-5-phosphatase D

affects expression

quercitrin affects the expression of INPP5D mRNA

NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746

G

insulin 1

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor

affects expression

quercitrin affects the expression of INSR mRNA

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

interferon regulatory factor 2 binding protein 2

increases expression

quercitrin results in increased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

integrin subunit beta 1

affects expression

quercitrin affects the expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

junction adhesion molecule like

increases expression

quercitrin results in increased expression of JAML mRNA

NCBI chr 8:45,384,836...45,415,459
Ensembl chr 8:45,383,495...45,416,565

G

Jupiter microtubule associated homolog 2

increases expression

quercitrin results in increased expression of JPT2 mRNA

NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170

G

lysine acetyltransferase 5

affects expression

quercitrin affects the expression of KAT5 mRNA

NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458

G

lysine demethylase 3A

increases expression

quercitrin results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

kinase insert domain receptor

increases expression

quercitrin results in increased expression of KDR mRNA

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

increases expression

quercitrin results in increased expression of KEAP1 mRNA

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kelch-like family member 28

increases expression

quercitrin results in increased expression of KLHL28 mRNA

NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164

G

keratin 81

decreases expression

quercitrin results in decreased expression of KRT81 mRNA

NCBI chr 7:132,577,112...132,582,238
Ensembl chr 7:132,576,492...132,582,170

G

lymphoid enhancer binding factor 1

affects expression

quercitrin affects the expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

lysophosphatidic acid receptor 3

increases expression

quercitrin results in increased expression of LPAR3 mRNA

NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357

G

lysophosphatidic acid receptor 5

increases expression

quercitrin results in increased expression of LPAR5 mRNA

NCBI chr 4:157,870,493...157,883,979
Ensembl chr 4:157,881,796...157,882,950

G

lysophosphatidic acid receptor 6

decreases expression

quercitrin results in decreased expression of LPAR6 mRNA

NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331

G

methionine adenosyltransferase 2A

increases expression

quercitrin results in increased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

melanocortin 1 receptor

increases expression

quercitrin results in increased expression of MC1R mRNA

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

MCTS1, re-initiation and release factor

decreases expression

quercitrin results in decreased expression of MCTS1 mRNA

NCBI chr X:117,350,723...117,362,504
Ensembl chr X:117,350,889...117,362,504

G

mitochondrial ribosomal protein L12

decreases expression

quercitrin results in decreased expression of MRPL12 mRNA

NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913

G

mitochondrial ribosomal protein L22

decreases expression

quercitrin results in decreased expression of MRPL22 mRNA

NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779

G

moesin

affects expression

quercitrin affects the expression of MSN mRNA

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

myosin light chain 2

affects expression

quercitrin affects the expression of MYL2 mRNA

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

G

myosin light chain 9

affects expression

quercitrin affects the expression of MYL9 mRNA

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myomesin 2

increases expression

quercitrin results in increased expression of MYOM2 mRNA

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

decreases expression

quercitrin results in decreased expression of LSMD1 mRNA

NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494

G

NFKB inhibitor alpha

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear factor related to kappa B binding protein

increases expression

quercitrin results in increased expression of NFRKB mRNA

NCBI chr 8:29,831,802...29,863,360
Ensembl chr 8:29,831,812...29,863,359

G

neuromedin U receptor 1

decreases expression

quercitrin results in decreased expression of NMUR1 mRNA

NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684

G

nitric oxide synthase 2

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptides B and W receptor 1

increases expression

quercitrin results in increased expression of NPBWR1 mRNA

NCBI chr 5:13,495,319...13,498,761
Ensembl chr 5:13,495,426...13,496,415

G

neuropeptide FF receptor 2

decreases expression

quercitrin results in decreased expression of NPFFR2 mRNA

NCBI chr14:18,513,120...18,558,074
Ensembl chr14:18,513,277...18,521,919

G

neuropeptide Y receptor Y5

increases expression

quercitrin results in increased expression of NPY5R mRNA

NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382

G

NUAK family kinase 2

decreases expression

quercitrin results in decreased expression of NUAK2 mRNA

NCBI chr13:43,753,454...43,770,604
Ensembl chr13:43,753,832...43,770,604

G

occludin

affects expression

quercitrin affects the expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

ornithine decarboxylase 1

increases expression

quercitrin results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

O-GlcNAcase

increases expression

quercitrin results in increased expression of OGA mRNA

NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359

G

2-oxoglutarate and iron-dependent oxygenase domain containing 2

increases expression

quercitrin results in increased expression of OGFOD2 mRNA

NCBI chr12:32,482,386...32,485,688
Ensembl chr12:32,482,377...32,485,673

G

OMA1 zinc metallopeptidase

increases expression

quercitrin results in increased expression of OMA1 mRNA

NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980

G

purinergic receptor P2X 2

increases expression

quercitrin results in increased expression of P2RX2 mRNA

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

G

purinergic receptor P2X 3

increases expression

quercitrin results in increased expression of P2RX3 mRNA

NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178

G

pyrimidinergic receptor P2Y6

decreases expression

quercitrin results in decreased expression of P2RY6 mRNA

NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808

G

poly (ADP-ribose) polymerase 1

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

POZ (BTB) and AT hook containing zinc finger 1

decreases expression

quercitrin results in decreased expression of PATZ1 mRNA

NCBI chr14:78,154,590...78,173,032
Ensembl chr14:78,152,516...78,173,032

G

peroxisomal biogenesis factor 16

decreases expression

quercitrin results in decreased expression of PEX16 mRNA

NCBI chr 3:78,347,212...78,352,603
Ensembl chr 3:78,343,164...78,353,207

G

pepsinogen A3

increases expression

quercitrin results in increased expression of PGA3 mRNA

NCBI chr 1:207,317,021...207,327,156
Ensembl chr 1:207,317,021...207,327,156

G

p53-induced death domain protein 1

increases expression

quercitrin results in increased expression of PIDD1 mRNA

NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

affects expression

quercitrin affects the expression of PIK3C2A mRNA

NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472

G

phosphoinositide-3-kinase regulatory subunit 1

affects expression

quercitrin affects the expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

phospholipase C, beta 2

affects expression

quercitrin affects the expression of PLCB2 mRNA

NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302

G

phospholipase C, epsilon 1

affects expression

quercitrin affects the expression of PLCE1 mRNA

NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438

G

plasminogen receptor with a C-terminal lysine

decreases expression

quercitrin results in decreased expression of PLGRKT mRNA

NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194

G

POC1 centriolar protein A

decreases expression

quercitrin results in decreased expression of POC1A mRNA

NCBI chr 8:106,922,058...106,991,678
Ensembl chr 8:106,922,978...106,991,089

G

DNA polymerase eta

increases expression

quercitrin results in increased expression of POLH mRNA

NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723

G

RNA polymerase mitochondrial

decreases expression

quercitrin results in decreased expression of POLRMT mRNA

NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791

G

protein-O-mannosyltransferase 2

increases expression

quercitrin results in increased expression of POMT2 mRNA

NCBI chr 6:106,755,462...106,794,849
Ensembl chr 6:106,755,462...106,794,849

G

POU domain class 5, transcription factor 2

decreases expression

quercitrin results in decreased expression of POU5F2 mRNA

NCBI chr 2:7,907,504...7,908,738

G

protein kinase C, beta

affects expression

quercitrin affects the expression of PRKCB mRNA

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

proline rich 3

decreases expression

quercitrin results in decreased expression of PRR3 mRNA

NCBI chr20:2,792,868...2,799,865
Ensembl chr20:2,792,860...2,799,865

G

pleckstrin and Sec7 domain containing 4

increases expression

quercitrin results in increased expression of PSD4 mRNA

NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571

G

proteasome 20S subunit alpha 6

decreases expression

quercitrin results in decreased expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554

G

proteasome 20S subunit alpha 8

decreases expression

quercitrin results in decreased expression of PSMA8 mRNA

NCBI chr18:5,863,594...5,928,226
Ensembl chr18:5,863,608...5,928,226

G

proteasome 20S subunit beta 6

decreases expression

quercitrin results in decreased expression of PSMB6 mRNA

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 9

decreases expression

quercitrin results in decreased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

prostaglandin D2 receptor 2

increases expression

quercitrin results in increased expression of PTGDR2 mRNA

NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213

G

protein tyrosine kinase 2 beta

affects expression

quercitrin affects the expression of PTK2B mRNA

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

G

protein tyrosine phosphatase, receptor type, U

decreases expression

quercitrin results in decreased expression of PTPRU mRNA

NCBI chr 5:143,950,542...144,024,791
Ensembl chr 5:143,950,965...144,024,768

G

Rac family small GTPase 3

affects expression

quercitrin affects the expression of RAC3 mRNA

NCBI chr10:106,002,808...106,005,243
Ensembl chr10:105,993,087...106,005,260

G

RAP1A, member of RAS oncogene family

affects expression

quercitrin affects the expression of RAP1A mRNA

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RB-associated KRAB zinc finger

increases expression

quercitrin results in increased expression of RBAK mRNA

NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934

G

ribokinase

decreases expression

quercitrin results in decreased expression of RBKS mRNA

NCBI chr 6:24,747,651...24,824,290
Ensembl chr 6:24,747,293...24,824,290

G

RNA binding motif protein 15B

increases expression

quercitrin results in increased expression of RBM15B mRNA

NCBI chr 8:107,543,613...107,546,678
Ensembl chr 8:107,525,898...107,551,696

G

RNA binding motif protein 38

increases expression

quercitrin results in increased expression of RBM38 mRNA

NCBI chr 3:161,801,577...161,814,381
Ensembl chr 3:161,801,577...161,814,381

G

RNA binding motif protein 39

increases expression

quercitrin results in increased expression of RBM39 mRNA

NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213

G

ring finger and CHY zinc finger domain containing 1

decreases expression

quercitrin results in decreased expression of RCHY1 mRNA

NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RIO kinase 1

increases expression

quercitrin results in increased expression of RIOK1 mRNA

NCBI chr17:26,767,440...26,789,900
Ensembl chr17:26,766,947...26,789,900

G

ring finger protein 14

decreases expression

quercitrin results in decreased expression of RNF14 mRNA

NCBI chr18:30,131,627...30,155,686
Ensembl chr18:30,131,691...30,155,685

G

Rho-associated coiled-coil containing protein kinase 1

affects expression

quercitrin affects the expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

RT1 class Ia, locus A2

affects expression

quercitrin affects the expression of HLA-E mRNA

NCBI chr20:4,870,939...4,910,183

G

RT1 class II, locus Ba

affects expression

quercitrin affects the expression of HLA-DQA1 mRNA

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class I, locus CE16

affects expression

quercitrin affects the expression of HLA-A mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

G

Sin3A associated protein 18

increases expression

quercitrin results in increased expression of SAP18 mRNA

NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
Ensembl chr10:31,943,230...31,950,038

G

spermidine/spermine N1-acetyl transferase 1

decreases expression

quercitrin results in decreased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

SERTA domain containing 1

increases expression

quercitrin results in increased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

splicing factor 3b, subunit 1

decreases expression

quercitrin results in decreased expression of SF3B1 mRNA

NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300

G

solute carrier family 16, member 13

decreases expression

quercitrin results in decreased expression of SLC16A13 mRNA

NCBI chr10:54,925,973...54,937,860
Ensembl chr10:54,926,760...54,937,788

G

solute carrier family 16, member 4

decreases expression

quercitrin results in decreased expression of SLC16A4 mRNA

NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117

G

solute carrier family 22, member 18

decreases expression

quercitrin results in decreased expression of SLC22A18 mRNA

NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975

G

solute carrier family 25, member 40

decreases expression

quercitrin results in decreased expression of SLC25A40 mRNA

NCBI chr 4:25,631,447...25,676,454
Ensembl chr 4:25,589,360...25,676,472

G

solute carrier family 39 member 8

decreases expression

quercitrin results in decreased expression of SLC39A8 mRNA

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129

G

solute carrier family 7 member 9

increases expression

quercitrin results in increased expression of SLC7A9 mRNA

NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641

G

schlafen-like 1

increases expression

quercitrin results in increased expression of SLFNL1 mRNA

NCBI chr 5:134,117,634...134,122,105
Ensembl chr 5:133,990,520...134,122,105

G

SMAD family member 3

increases expression

quercitrin results in increased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

sphingomyelin phosphodiesterase 1

increases expression

quercitrin results in increased expression of SMPD1 mRNA

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

snail family transcriptional repressor 2

affects expression

quercitrin affects the expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

sorbin and SH3 domain containing 1

affects expression

quercitrin affects the expression of SORBS1 mRNA

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

sortilin related receptor 1

decreases expression

quercitrin results in decreased expression of SORL1 mRNA

NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513

G

Sp4 transcription factor

increases expression

quercitrin results in increased expression of SP4 mRNA

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

G

spermatogenesis associated 18

increases expression

quercitrin results in increased expression of SPATA18 mRNA

NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687

G

SRC proto-oncogene, non-receptor tyrosine kinase

affects expression

quercitrin affects the expression of SRC mRNA

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroid 5 alpha-reductase 3

increases expression

quercitrin results in increased expression of SRD5A3 mRNA

NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747

G

serine/arginine repetitive matrix 2

increases expression

quercitrin results in increased expression of SRRM2 mRNA

NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751

G

succinylCoA:glutarate-CoA transferase

increases expression

quercitrin results in increased expression of SUGCT mRNA

NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376

G

SURP and G patch domain containing 1

increases expression

quercitrin results in increased expression of SUGP1 mRNA

NCBI chr16:19,352,659...19,383,533
Ensembl chr16:19,351,793...19,383,756

G

transcription elongation factor A1

decreases expression

quercitrin results in decreased expression of TCEA1 mRNA

NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
Ensembl chr15:14,631,454...14,668,745

G

transcription elongation factor A2

decreases expression

quercitrin results in decreased expression of TCEA2 mRNA

NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116

G

transcription factor 7

affects expression

quercitrin affects the expression of TCF7 mRNA

NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535

G

transcription factor B1, mitochondrial

decreases expression

quercitrin results in decreased expression of TFB1M mRNA

NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709

G

TGFB-induced factor homeobox 2

decreases expression

quercitrin results in decreased expression of TGIF2 mRNA

NCBI chr 3:145,333,152...145,348,599
Ensembl chr 3:145,333,418...145,348,596

G

transglutaminase 2

decreases expression

quercitrin results in decreased expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

thrombospondin type 1 domain containing 1

increases expression

quercitrin results in increased expression of THSD1 mRNA

NCBI chr16:69,771,408...69,804,844
Ensembl chr16:69,771,408...69,801,504

G

transmembrane protein 160

decreases expression

quercitrin results in decreased expression of TMEM160 mRNA

NCBI chr 1:77,164,448...77,167,156
Ensembl chr 1:77,164,448...77,167,156

G

transmembrane protein 208

decreases expression

quercitrin results in decreased expression of TMEM208 mRNA

NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183

G

transmembrane protein 242

increases expression

quercitrin results in increased expression of TMEM242 mRNA

NCBI chr 1:45,992,713...46,019,684
Ensembl chr 1:45,992,713...46,019,626

G

thioredoxin-related transmembrane protein 1

decreases expression

quercitrin results in decreased expression of TMX1 mRNA

NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301

G

tumor necrosis factor

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

decreases expression

quercitrin results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

decreases expression

quercitrin results in decreased expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

tumor protein p63

decreases expression

quercitrin results in decreased expression of TP63 mRNA

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

tetraspanin 14

decreases expression

quercitrin results in decreased expression of TSPAN14 mRNA

NCBI chr16:16,784,242...16,841,368
Ensembl chr16:16,783,234...16,841,400

G

U2 small nuclear RNA auxiliary factor 2

increases expression

quercitrin results in increased expression of U2AF2 mRNA

NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492

G

urotensin 2 receptor

increases expression

quercitrin results in increased expression of UTS2R mRNA

NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252

G

vomeronasal 1 receptor 51

increases expression

quercitrin results in increased expression of VN1R1 mRNA

G

von Willebrand factor A domain containing 8

decreases expression

quercitrin results in decreased expression of VWA8 mRNA

NCBI chr15:54,252,703...54,576,871
Ensembl chr15:54,252,584...54,576,870

G

WASP actin nucleation promoting factor

affects expression

quercitrin affects the expression of WAS mRNA

NCBI chr X:14,405,105...14,413,850
Ensembl chr X:14,405,124...14,413,849

G

WD repeat domain 33

decreases expression

quercitrin results in decreased expression of WDR33 mRNA

NCBI chr18:23,432,233...23,535,460
Ensembl chr18:23,432,191...23,468,597

G

WW domain-containing oxidoreductase

decreases expression

quercitrin results in decreased expression of WWOX mRNA

NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391

G

zonadhesin

increases expression

quercitrin results in increased expression of ZAN mRNA

NCBI chr12:19,215,018...19,322,789
Ensembl chr12:19,215,102...19,271,240

G

zinc finger CCHC-type containing 14

increases expression

quercitrin results in increased expression of ZCCHC14 mRNA

NCBI chr19:49,674,185...49,718,004
Ensembl chr19:49,674,195...49,718,029

G

zinc finger protein 502

increases expression

quercitrin results in increased expression of ZNF502 mRNA

NCBI chr 1:28,884,390...28,908,726

rutin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

multiple interactions

Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetylcholinesterase

multiple interactions

Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of ACHE protein]; Rutin inhibits the reaction [Acrylamide results in increased expression of ACHE protein]

PMID:32881150 PMID:36657526

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

decreases activity

Rutin results in decreased activity of ACLY protein

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

advanced glycosylation end product-specific receptor

multiple interactions

Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA]

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

multiple interactions

Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

decreases localization
multiple interactions

Rutin results in decreased localization of AHR protein
Rutin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]
Rutin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]

PMID:22426011 PMID:35304134

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aryl hydrocarbon receptor nuclear translocator

increases localization

Rutin results in increased localization of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

ataxin 2

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 3

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2-associated agonist of cell death

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

Rutin affects the expression of BAX protein
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
Rutin results in increased expression of BAX protein

PMID:15975156 PMID:28811126 PMID:29522708 PMID:32881150 PMID:33413359

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of BBC3 mRNA]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

affects expression
multiple interactions
decreases expression

Rutin affects the expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]
Rutin results in decreased expression of BCL2 protein
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BCL2 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]
Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]

PMID:15975156 PMID:19557821 PMID:26062544 PMID:28811126 PMID:29522708 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bone gamma-carboxyglutamate protein

multiple interactions

[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased secretion of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of BRAF protein]

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

caspase 1

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity

Rutin affects the cleavage of CASP3 protein
Rutin results in increased cleavage of CASP3 protein
Rutin inhibits the reaction [Cholesterol, Dietary results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 mRNA]
[Rutin binds to Zinc] which results in increased expression of CASP3 mRNA; [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]
Rutin results in increased expression of CASP3 mRNA
Rutin results in increased activity of CASP3 protein

PMID:15975156 PMID:24726691 PMID:24908156 PMID:25129099 PMID:26091902 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Rutin results in increased activity of CASP7 protein
Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]

PMID:24726691 PMID:25129099

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases expression

[Rutin binds to Zinc] which results in increased expression of CASP8 mRNA
Rutin results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Rutin inhibits the reaction [Cisplatin results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]
Rutin inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Rutin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]

PMID:19833193 PMID:21605616 PMID:25478064 PMID:25753322 PMID:29743444 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

multiple interactions

Rutin binds to and results in decreased activity of CBR1 protein; Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

PMID:11306090 PMID:18579125

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 2

multiple interactions
decreases secretion
decreases expression

Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
Rutin results in decreased secretion of CCL2 protein
Rutin results in decreased expression of CCL2 mRNA

PMID:21756928 PMID:21967610 PMID:25478064

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions
decreases expression

Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

multiple interactions

Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions
decreases expression

[Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA
Rutin results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Cd68 molecule

decreases expression

Rutin results in decreased expression of CD68 protein

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

choline O-acetyltransferase

multiple interactions

Rutin inhibits the reaction [Acrylamide results in decreased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

collagen type I alpha 1 chain

multiple interactions

[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

colony stimulating factor 2

multiple interactions

Rutin inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 mRNA]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X3-C motif chemokine ligand 1

decreases expression

Rutin results in decreased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 10

multiple interactions
decreases secretion
decreases expression

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]
Rutin results in decreased secretion of CXCL10 protein
Rutin results in decreased expression of CXCL10 mRNA

PMID:21756928 PMID:21967610

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression
multiple interactions

Rutin results in decreased expression of CXCL12 mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CXCL12 mRNA]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome c, somatic

multiple interactions

Rutin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

Rutin results in increased expression of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Rutin results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Rutin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

epidermal growth factor

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

estrogen receptor 2

increases expression

Rutin results in increased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fas associated via death domain

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA]

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

fibronectin 1

increases expression
multiple interactions

Rutin results in increased expression of FN1 protein
Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]

PMID:24117263 PMID:26408079

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Rutin inhibits the reaction [oxaliplatin results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O3

multiple interactions

Rutin inhibits the reaction [Cisplatin affects the localization of FOXO3 protein]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone receptor

increases expression

Rutin results in increased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glial cell derived neurotrophic factor

increases expression

Rutin results in increased expression of GDNF mRNA

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glutamic--pyruvic transaminase

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of GPT protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]

PMID:25478064 PMID:25753322 PMID:26062544 PMID:27239252

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Rutin results in decreased activity of GSR protein
Rutin inhibits the reaction [Cisplatin results in decreased expression of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]

PMID:15782287 PMID:21605616 PMID:25753322

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Rutin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

[Rutin co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interferon gamma

multiple interactions

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

[Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein]

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 10

multiple interactions
increases expression

Lipopolysaccharides promotes the reaction [Rutin results in increased expression of IL10 mRNA]
Rutin results in increased expression of IL10 mRNA; Rutin results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

multiple interactions
decreases expression

Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Rutin results in decreased expression of IL18 mRNA

PMID:22426011 PMID:28693884

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
decreases expression

Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein]
Rutin results in decreased expression of IL1B mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL1B mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]

PMID:15652231 PMID:18958421 PMID:19557821 PMID:22426011 PMID:28693884 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
Rutin results in decreased expression of IL6 mRNA; Rutin results in decreased expression of IL6 protein
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL6 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]
Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:15652231 PMID:18958421 PMID:21756928 PMID:22426011 PMID:25753322 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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insulin 1

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

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insulin receptor substrate 1

decreases expression
multiple interactions

Rutin results in decreased expression of IRS1 protein
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]

PMID:20015448 PMID:22426011

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

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integrin subunit alpha M

increases expression
multiple interactions

Rutin results in increased expression of ITGAM protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

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Janus kinase 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA]

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

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Janus kinase 2

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Rutin results in decreased expression of JUN protein
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

laminin subunit beta 2

increases expression

Rutin results in increased expression of LAMB2 protein

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

leptin

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of LEP protein]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 9

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]

NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045

G

mitogen activated protein kinase kinase 5

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K5 mRNA]

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Acrylamide results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK1 protein]
Rutin results in decreased phosphorylation of MAPK1 protein

PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

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mitogen activated protein kinase 14

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Acrylamide results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK3 protein]
Rutin results in decreased phosphorylation of MAPK3 protein

PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

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mitogen-activated protein kinase 8

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microRNA 100

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR100 mRNA]

NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304

G

microRNA 125b-1

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR125B1 mRNA]

NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052

G

microRNA 1306

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR1306 mRNA]

NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719

G

microRNA 152

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR152 mRNA]

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 181c

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR181C mRNA]

NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628

G

microRNA 185

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR185 mRNA]

NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795

G

microRNA 195

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR195 mRNA]

NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924

G

microRNA 196c

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR196C mRNA]

NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085

G

microRNA 199a-2

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR199A2 mRNA]

NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063

G

microRNA 204

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR204 mRNA]

NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040

G

microRNA 208b

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR208B mRNA]

NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749

G

microRNA 211

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR211 mRNA]

NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644

G

microRNA 22

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR22 mRNA]

NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133

G

microRNA 26b

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR26B mRNA]

NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680

G

microRNA 296

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR296 mRNA]

NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915

G

microRNA 30c-1

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR30C1 mRNA]

NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325

G

microRNA 3558

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3558 mRNA]

NCBI chr 6:7,181,751...7,181,864
Ensembl chr 6:7,181,751...7,181,864

G

microRNA 3584

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3584 mRNA]

NCBI chr 1:246,786,249...246,786,329
Ensembl chr 1:246,786,249...246,786,329

G

microRNA 3588

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3588 mRNA]

NCBI chr11:16,245,611...16,245,716
Ensembl chr11:16,245,611...16,245,716

G

microRNA 365b

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR365B mRNA]

NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351

G

microRNA 494

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR494 mRNA]

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

microRNA 6216

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR6216 mRNA]

NCBI chr 3:44,756,861...44,756,938
Ensembl chr 3:44,756,861...44,756,938

G

microRNA 664-2

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR664-2 mRNA]

NCBI chr13:96,793,099...96,793,157
Ensembl chr13:96,793,099...96,793,157

G

microRNA 760

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR760 mRNA]

NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695

G

matrix metallopeptidase 2

multiple interactions

Rutin results in decreased expression of and results in decreased activity of MMP2 protein
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]

PMID:26408079 PMID:29743444

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Rutin results in decreased expression of MMP9 mRNA
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]

PMID:16304905 PMID:29743444

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mannose receptor, C type 1

increases expression
multiple interactions

Rutin results in increased expression of MRC1 protein
[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

NFE2 like bZIP transcription factor 2

multiple interactions

Rutin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]
[Rutin co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; Rutin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein]

PMID:22902988 PMID:31412289 PMID:36657526

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
decreases expression

Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Rutin results in decreased expression of NOS2 mRNA; Rutin results in decreased expression of NOS2 protein
Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:11500931 PMID:12512693 PMID:22902988 PMID:25080890 PMID:25753322 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neuronal vesicle trafficking associated 1

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

Parkinsonism associated deglycase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

patatin-like phospholipase domain containing 3

decreases expression

Rutin results in decreased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

paraoxonase 1

multiple interactions
increases expression

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 protein]
Rutin results in increased expression of PON1 mRNA

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

paraoxonase 3

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein]

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

peroxisome proliferator activated receptor alpha

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein]

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peptidylprolyl isomerase D

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

phosphatase and tensin homolog

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

[Rutin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
Rutin results in decreased expression of PTGS2 mRNA
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]

PMID:11500931 PMID:15652231 PMID:19557821 PMID:21756928 PMID:22902988 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAP1A, member of RAS oncogene family

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A mRNA]; Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [Glucose affects the localization of RELA protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Rutin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]

PMID:19557821 PMID:21756928 PMID:29522708

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RUNX family transcription factor 2

multiple interactions

[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sirtuin 1

increases expression

Rutin results in increased expression of SIRT1 mRNA; Rutin results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

signaling lymphocytic activation molecule family member 1

increases expression
multiple interactions

Rutin results in increased expression of SLAMF1 protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of SLAMF1 protein]

NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497

G

solute carrier family 22 member 1

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 12

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22 member 2

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 6

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 2 member 9

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]

NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981

G

solute carrier organic anion transporter family member 1B2

multiple interactions

Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2b1

multiple interactions
affects localization

Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Cholic Acid]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Taurocholic Acid]
Rutin affects the localization of SLCO2B1 protein

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

SMAD family member 2

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 4

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

suppressor of cytokine signaling 3

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sorbitol dehydrogenase

multiple interactions

[Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Rutin inhibits the reaction [Formaldehyde affects the activity of SORD protein]

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

steroidogenic acute regulatory protein

increases expression

Rutin results in increased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of STAT3 mRNA]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]

PMID:22426011 PMID:26062544

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor alpha

multiple interactions

Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]

PMID:22902988 PMID:24117263 PMID:27239252 PMID:28693884

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions
decreases expression

Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]
Rutin results in decreased expression of TNF mRNA; Rutin results in decreased expression of TNF protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Rutin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Rutin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]

PMID:14654164 PMID:18958421 PMID:19557821 PMID:21605616 PMID:21756928 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TP53 mRNA]
Rutin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TRP53 protein]

PMID:27239252 PMID:29522708 PMID:29962303

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

ubiquitin C-terminal hydrolase L1

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

vascular cell adhesion molecule 1

multiple interactions

Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions
decreases expression

Rutin results in decreased secretion of and results in decreased expression of VEGFA protein; Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA]; Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA]; Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein]
Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]

PMID:20015448 PMID:33413359

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

xanthine dehydrogenase

multiple interactions

Rutin inhibits the reaction [Cyclophosphamide results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19921
role	19893
chemical role	19524
antioxidant	16167
quercetin	4326
quercetin O-glycoside	466
avicularin	0
hermannioside A	0
miquelianin	33
quercetin 3,7-di-O-alpha-L-rhamnoside	0
quercetin 3-(6''-p-hydroxybenzoylgalactoside)	0
quercetin 3-O-(2'',3''-digalloyl)-beta-D-galactopyranoside	0
quercetin 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside	0
quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside)	0
quercetin 3-O-alpha-D-rhamnofuranoside	0
quercetin 3-O-alpha-L-fucopyranoside	0
quercetin 3-O-alpha-L-rhamnofuranoside	0
quercetin 3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside	0
quercetin 3-O-arabinoside 7-O-rhamnoside	0
quercetin 3-O-beta-D-fucopyranoside	0
quercetin 3-O-beta-D-galactopyranoside +	38
quercetin 3-O-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside	0
quercetin 3-O-beta-L-fucopyranoside	0
quercetin 3-O-beta-L-rhamnofuranoside	0
quercetin 3-beta-gentiobioside	0
quercetin 3-beta-gentiobioside(2-)	0
quercetin 3-beta-gentiotrioside	0
quercetin 4'-O-alpha-L-rhamnopyranosyl-3-O-beta-D-allopyranoside	0
quercetin 7-O-alpha-D-rhamnopyranoside	0
quercetin 7-O-alpha-L-rhamnopyranoside	0
quercetin 7-O-beta-L-rhamnopyranoside	0
quercetin O-glucoside +	205
quercetin-3-O-alpha-D-arabinofuranoside	0
quercetin-3-O-arabinoside	0
quercetin-3-O-beta-D-xylopyranoside	0
quercetin-7-O-[alpha-L-rhamnopyranosyl(1->6)-beta-D-galactopyranoside]	0
quercitrin	245
Path 2
Term	Annotations
CHEBI ontology	19921
subatomic particle	19919
composite particle	19919
hadron	19919
baryon	19919
nucleon	19919
atomic nucleus	19919
atom	19919
main group element atom	19865
p-block element atom	19865
carbon group element atom	19804
carbon atom	19801
organic molecular entity	19801
organic molecule	19754
organic cyclic compound	19544
organic heterocyclic compound	18909
oxacycle	17905
benzopyran	11977
1-benzopyran	11731
flavonoid	7225
anthoxanthin	4579
flavones	4579
hydroxyflavone	4557
flavonols	4428
7-hydroxyflavonol	4393
quercetin	4326
quercetin O-glycoside	466
avicularin	0
hermannioside A	0
miquelianin	33
quercetin 3,7-di-O-alpha-L-rhamnoside	0
quercetin 3-(6''-p-hydroxybenzoylgalactoside)	0
quercetin 3-O-(2'',3''-digalloyl)-beta-D-galactopyranoside	0
quercetin 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside	0
quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside)	0
quercetin 3-O-alpha-D-rhamnofuranoside	0
quercetin 3-O-alpha-L-fucopyranoside	0
quercetin 3-O-alpha-L-rhamnofuranoside	0
quercetin 3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside	0
quercetin 3-O-arabinoside 7-O-rhamnoside	0
quercetin 3-O-beta-D-fucopyranoside	0
quercetin 3-O-beta-D-galactopyranoside +	38
quercetin 3-O-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside	0
quercetin 3-O-beta-L-fucopyranoside	0
quercetin 3-O-beta-L-rhamnofuranoside	0
quercetin 3-beta-gentiobioside	0
quercetin 3-beta-gentiobioside(2-)	0
quercetin 3-beta-gentiotrioside	0
quercetin 4'-O-alpha-L-rhamnopyranosyl-3-O-beta-D-allopyranoside	0
quercetin 7-O-alpha-D-rhamnopyranoside	0
quercetin 7-O-alpha-L-rhamnopyranoside	0
quercetin 7-O-beta-L-rhamnopyranoside	0
quercetin O-glucoside +	205
quercetin-3-O-alpha-D-arabinofuranoside	0
quercetin-3-O-arabinoside	0
quercetin-3-O-beta-D-xylopyranoside	0
quercetin-7-O-[alpha-L-rhamnopyranosyl(1->6)-beta-D-galactopyranoside]	0
quercitrin	245

paths to the root