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Accession:CHEBI:76400 term browser browse the term
Definition:A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.
Synonyms:exact_synonym: 3-amino-5-(azepan-1-yl)-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
 related_synonym: 3-Amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide;   Formula=C12H18ClN7O;   HMA;   HMA-5;   Hexamethylene amiloride;   Hexamethyleneamiloride;   InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21);   InChIKey=RQQJJXVETXFINY-UHFFFAOYSA-N;   SMILES=NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1
 xref: CAS:1428-95-1 "ChemIDplus";   LINCS:LSM-2912
 xref_mesh: MESH:C057360
 xref: PMID:12046895 "Europe PMC";   PMID:21978672 "Europe PMC";   PMID:22472891 "Europe PMC";   PMID:23205553 "Europe PMC";   PMID:23329732 "Europe PMC";   PMID:23383318 "Europe PMC";   PMID:23800993 "Europe PMC";   PMID:23841474 "Europe PMC";   PMID:23996609 "Europe PMC";   Reaxys:628353 "Reaxys"

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5-(N,N-hexamethylene)amiloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          apoptosis inducer 10783
            5-(N,N-hexamethylene)amiloride 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  5-(N,N-hexamethylene)amiloride 6
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.