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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.3.1.48 (histone acetyltransferase) inhibitor
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Accession:CHEBI:76395 term browser browse the term
Definition:An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48).
Synonyms:related_synonym: EC 2.3.1.48 inhibitor;   EC 2.3.1.48 inhibitors;   HAT inhibitor;   HAT inhibitors;   acetyl-CoA:histone acetyltransferase inhibitor;   acetyl-CoA:histone acetyltransferase inhibitors;   histone acetokinase inhibitor;   histone acetokinase inhibitors;   histone acetylase inhibitor;   histone acetylase inhibitors;   histone acetyltransferase (EC 2.3.1.48) inhibitors;   histone acetyltransferase inhibitor;   histone acetyltransferase inhibitors;   histone transacetylase inhibitor;   histone transacetylase inhibitors;   nucleosome-histone acetyltransferase inhibitor;   nucleosome-histone acetyltransferase inhibitors
 xref: Wikipedia:Histone_acetyltransferase



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C646 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir224 microRNA 224 decreases expression ISO C646 decreased expression of miR244 in a human hepatocellular carcinoma cell line RGD PMID:22459148 RGD:18182922 NCBI chr  X:150,065,088...150,065,169 JBrowse link
pentamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Pentamidine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 decreases activity ISO Pentamidine results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:167,307,984...167,336,812 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Pentamidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:36,752,061...36,769,970 JBrowse link
G Atm ATM serine/threonine kinase affects localization
decreases activity
ISO Pentamidine affects the localization of ATM protein modified form
Pentamidine results in decreased activity of ATM protein
CTD PMID:20144237 NCBI chr 8:62,724,939...62,829,040 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Pentamidine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO Pentamidine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Pentamidine results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Pentamidine results in increased expression of DEPP1 mRNA CTD PMID:15342952 NCBI chr 4:149,910,794...149,913,013 JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pentamidine results in decreased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 4:104,744,302...104,753,119 JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Pentamidine results in increased expression of FNDC4 mRNA CTD PMID:15342952 NCBI chr 6:25,077,155...25,080,812 JBrowse link
G H2ax H2A.X variant histone affects localization ISO Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 NCBI chr 8:53,568,718...53,570,072 JBrowse link
G Hpn hepsin increases expression ISO Pentamidine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785 JBrowse link
G Ifng interferon gamma multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD PMID:15588918 PMID:29594315 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein CTD PMID:12803856 NCBI chr 1:16,152,811...16,171,439 JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein
Pentamidine results in decreased expression of IL10 protein
CTD PMID:15588918 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Pentamidine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD PMID:15588918 PMID:29594315 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Pentamidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:65,061,531...65,064,519 JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions
decreases activity
ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
Pentamidine results in decreased activity of KAT5 protein
CTD PMID:20144237 NCBI chr 1:212,325,089...212,332,640 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pentamidine results in decreased activity of KCNH2 protein
CTD PMID:15340016 PMID:15711590 PMID:21158687 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Lss lanosterol synthase decreases expression ISO Pentamidine results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,090,641...12,118,230 JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases activity ISO Pentamidine results in decreased activity of MRE11 protein CTD PMID:20144237 NCBI chr 8:19,900,211...19,961,906 JBrowse link
G Nbn nibrin affects localization ISO Pentamidine affects the localization of NBN protein CTD PMID:20144237 NCBI chr 5:34,256,678...34,291,163 JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Pentamidine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:145,779,294...145,782,609 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Pentamidine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:25,733,471...25,829,440 JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Pentamidine results in increased expression of NUPR1 mRNA CTD PMID:15342952 NCBI chr 1:190,643,866...190,645,901 JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Pentamidine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,598,475...4,604,118 JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Pentamidine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:123,323,623...123,331,181 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Pentamidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:157,632,887...157,698,034 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] CTD PMID:20144237 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Pentamidine results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:95,042,451...95,079,679 JBrowse link
procyanidin B3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA CTD PMID:22169119 NCBI chr20:4,152,758...4,155,956 JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO [[procyanidin B1 co-treated with procyanidin B3] co-treated with Catechin] results in increased expression of AQP3 mRNA CTD PMID:33294640 NCBI chr 5:61,035,165...61,040,683 JBrowse link
G Cat catalase multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of CAT mRNA CTD PMID:22169119 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22169119 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] CTD PMID:22169119 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA] CTD PMID:22169119 NCBI chr10:67,514,095...67,515,945 JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA] CTD PMID:22169119 NCBI chr11:75,760,073...75,798,978 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA] CTD PMID:22169119 NCBI chr10:38,887,692...38,889,673 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA] CTD PMID:22169119 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA CTD PMID:22169119 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA] CTD PMID:22169119 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Il10 interleukin 10 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:22169119 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il12b interleukin 12B multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:22169119 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22169119 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA] CTD PMID:22169119 NCBI chr17:66,849,974...66,898,665 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22169119 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA] CTD PMID:22169119 NCBI chr17:58,078,175...58,098,455 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein; Eicosapentaenoic Acid promotes the reaction [[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein]; procyanidin B3 promotes the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in decreased phosphorylation of MAPK8 protein] CTD PMID:22169119 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA] CTD PMID:22169119 NCBI chr16:52,717,775...52,803,602 JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 mRNA] CTD PMID:22169119 NCBI chr 1:255,106,010...255,114,649 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO procyanidin B3 inhibits the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in increased phosphorylation of RELA protein] CTD PMID:22169119 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA] CTD PMID:22169119 NCBI chr12:25,237,977...25,248,356 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA] CTD PMID:22169119 NCBI chr 5:157,070,642...157,104,216 JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        biochemical role 19577
          enzyme inhibitor 18779
            EC 2.* (transferase) inhibitor 14984
              EC 2.3.* (acyltransferase) inhibitor 632
                EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor 482
                  EC 2.3.1.48 (histone acetyltransferase) inhibitor 56
                    1-(butan-2-ylidene)-2-[4-(4-chlorophenyl)thiazol-2-yl]hydrazine 0
                    1-[4-(4-chlorophenyl)thiazol-2-yl]-2-(pentan-3-ylidene)hydrazine 0
                    1-[4-(4-chlorophenyl)thiazol-2-yl]-2-(propan-2-ylidene)hydrazine 0
                    C646 1
                    anacardic acid 0
                    cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone 0
                    hydrazinocurcumin 0
                    pentamidine 34
                    procyanidin B3 + 23
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