CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: EC 2.3.1.48 (histone acetyltransferase) inhibitor
Accession: CHEBI:76395
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Definition: An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48).
Synonyms: related_synonym: EC 2.3.1.48 (histone acetyltransferase) inhibitors; EC 2.3.1.48 inhibitor; EC 2.3.1.48 inhibitors; HAT inhibitor; HAT inhibitors; acetyl-CoA:histone acetyltransferase inhibitor; acetyl-CoA:histone acetyltransferase inhibitors; histone acetokinase inhibitor; histone acetokinase inhibitors; histone acetylase inhibitor; histone acetylase inhibitors; histone acetyltransferase inhibitor; histone acetyltransferase inhibitors; histone transacetylase inhibitor; histone transacetylase inhibitors; nucleosome-histone acetyltransferase inhibitor; nucleosome-histone acetyltransferase inhibitors
xref: Wikipedia:Histone_acetyltransferase
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Mir224
microRNA 224
decreases expression
ISO
C646 decreased expression of miR244 in a human hepatocellular carcinoma cell line
RGD
PMID:22459148
RGD:18182922
NCBI chr X:152,223,754...152,223,835
Ensembl chr X:152,223,754...152,223,835
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Ar
androgen receptor
multiple interactions
ISO
Pentamidine binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Asic5
acid sensing ion channel subunit family member 5
decreases activity
ISO
Pentamidine results in decreased activity of ASIC5 protein
CTD
PMID:21828194
NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Pentamidine results in increased expression of ASNS mRNA
CTD
PMID:15342952
NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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Atm
ATM serine/threonine kinase
affects localization decreases activity
ISO
Pentamidine affects the localization of ATM protein modified form Pentamidine results in decreased activity of ATM protein
CTD
PMID:20144237
NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
Pentamidine results in decreased activity of CYP2C19 protein
CTD
PMID:11124226
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Pentamidine results in decreased activity of CYP2D6 protein
CTD
PMID:11124226
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases activity
ISO
Pentamidine results in decreased activity of CYP3A4 protein
CTD
PMID:11124226
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Depp1
DEPP1, autophagy regulator
increases expression
ISO
Pentamidine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952
NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
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Fabp1
fatty acid binding protein 1
decreases expression
ISO
Pentamidine results in decreased expression of FABP1 mRNA
CTD
PMID:15342952
NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Pentamidine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952
NCBI chr 6:26,387,284...26,389,524
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H2ax
H2A.X variant histone
affects localization
ISO
Pentamidine affects the localization of H2AX protein modified form
CTD
PMID:20144237
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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Hpn
hepsin
increases expression
ISO
Pentamidine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
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Ifng
interferon gamma
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein
CTD
PMID:12803856
NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
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Il10
interleukin 10
multiple interactions decreases expression
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein Pentamidine results in decreased expression of IL10 protein
CTD
PMID:15588918
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il1b
interleukin 1 beta
decreases expression
ISO
Pentamidine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il2
interleukin 2
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:15588918 PMID:29594315
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il4
interleukin 4
multiple interactions
ISO
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein
CTD
PMID:15588918
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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Inhbe
inhibin subunit beta E
increases expression
ISO
Pentamidine results in increased expression of INHBE mRNA
CTD
PMID:15342952
NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
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Kat5
lysine acetyltransferase 5
multiple interactions decreases activity
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] Pentamidine results in decreased activity of KAT5 protein
CTD
PMID:20144237
NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Pentamidine results in decreased activity of KCNH2 protein
CTD
PMID:15340016 PMID:15711590 PMID:21158687
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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LOC299277
similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B
increases expression
ISO
Pentamidine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952
NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
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Lss
lanosterol synthase
decreases expression
ISO
Pentamidine results in decreased expression of LSS mRNA
CTD
PMID:15342952
NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
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Mre11
MRE11 homolog, double strand break repair nuclease
decreases activity
ISO
Pentamidine results in decreased activity of MRE11 protein
CTD
PMID:20144237
NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
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Nbn
nibrin
affects localization
ISO
Pentamidine affects the localization of NBN protein
CTD
PMID:20144237
NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Pentamidine results in increased expression of NR0B2 mRNA
CTD
PMID:15342952
NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases activity
ISO
Pentamidine results in increased activity of NR1H4 protein
CTD
PMID:22414727
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Pentamidine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952
NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
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RT1-Bb
RT1 class II, locus Bb
affects expression
ISO
Pentamidine affects the expression of HLA-DQB1 mRNA
CTD
PMID:25811541
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Pentamidine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 Ensembl chr 4:155,408,233...155,631,856
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Tp53
tumor protein p53
multiple interactions
ISO
Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
CTD
PMID:20144237
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Pentamidine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952
NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA
CTD
PMID:22169119
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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Cat
catalase
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of CAT mRNA
CTD
PMID:22169119
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
CTD
PMID:22169119
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
CTD
PMID:22169119
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Ccl7
C-C motif chemokine ligand 7
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA]
CTD
PMID:22169119
NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
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Cd80
Cd80 molecule
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]
CTD
PMID:22169119
NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
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Csf2
colony stimulating factor 2
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]
CTD
PMID:22169119
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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Fas
Fas cell surface death receptor
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA]
CTD
PMID:22169119
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of GCLM mRNA
CTD
PMID:22169119
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]
CTD
PMID:22169119
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Il10
interleukin 10
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
CTD
PMID:22169119
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il12b
interleukin 12B
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]
CTD
PMID:22169119
NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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Il1b
interleukin 1 beta
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:22169119
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il2ra
interleukin 2 receptor subunit alpha
multiple interactions
ISO
procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]
CTD
PMID:22169119
NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
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Il6
interleukin 6
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:22169119
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Map3k8
mitogen-activated protein kinase kinase kinase 8
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]
CTD
PMID:22169119
NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein; Eicosapentaenoic Acid promotes the reaction [[Lipopolysaccharides co-treated with procyanidin B3] results in decreased phosphorylation of MAPK8 protein]; procyanidin B3 promotes the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in decreased phosphorylation of MAPK8 protein]
CTD
PMID:22169119
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Msr1
macrophage scavenger receptor 1
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA]
CTD
PMID:22169119
NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
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Nfkb2
nuclear factor kappa B subunit 2
multiple interactions
ISO
[Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 mRNA]
CTD
PMID:22169119
NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
procyanidin B3 inhibits the reaction [[Lipopolysaccharides co-treated with Eicosapentaenoic Acid] results in increased phosphorylation of RELA protein]
CTD
PMID:22169119
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Serpine1
serpin family E member 1
multiple interactions
ISO
[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]
CTD
PMID:22169119
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Tnfrsf1b
TNF receptor superfamily member 1B
multiple interactions
ISO
procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]
CTD
PMID:22169119
NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
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