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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,6-diaminotoluene
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Accession:CHEBI:76288 term browser browse the term
Definition:A diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups.
Synonyms:exact_synonym: 2-methylbenzene-1,3-diamine
 related_synonym: 2,6-DAT;   2,6-diamino-1-methylbenzene;   2,6-toluylenediamine;   2,6-tolylenediamine;   2-methyl-1,3-benzenediamine;   2-methyl-1,3-phenylenediamine;   2-methyl-m-phenylenediamine;   EINECS 212-513-9;   Formula=C7H10N2;   InChI=1S/C7H10N2/c1-5-6(8)3-2-4-7(5)9/h2-4H,8-9H2,1H3;   InChIKey=RLYCRLGLCUXUPO-UHFFFAOYSA-N;   SMILES=Cc1c(N)cccc1N;   o-toluene diamine;   toluene-2,6-diamine
 xref: CAS:823-40-5;   HMDB:HMDB0041801
 xref_mesh: MESH:C025235
 xref: PMID:1747922;   PMID:20026473;   PMID:2575496;   PMID:7586147;   PMID:7678174;   PMID:7761993;   Reaxys:2079476


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2,6-diaminotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression EXP 2,6-diaminotoluene results in decreased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase increases expression EXP 2,6-diaminotoluene results in increased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:39,200,486...39,244,337
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:80,140,996...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression EXP 2,6-diaminotoluene results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2,6-diaminotoluene results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of ALDH1A4 mRNA CTD PMID:17070881 NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:218,201,472...218,248,906 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2,6-diaminotoluene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:97,656,725...97,672,211
Ensembl chr 6:97,656,576...97,672,303 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 2,6-diaminotoluene results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression EXP 2,6-diaminotoluene results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G C7 complement C7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G Cblc Cbl proto-oncogene C decreases expression EXP 2,6-diaminotoluene results in decreased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2,6-diaminotoluene results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd276 Cd276 molecule decreases expression EXP 2,6-diaminotoluene results in decreased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP 2,6-diaminotoluene results in increased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2,6-diaminotoluene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546 		JBrowse link
G Cryab crystallin, alpha B decreases expression EXP 2,6-diaminotoluene results in decreased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP 2,6-diaminotoluene results in decreased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2,6-diaminotoluene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2,6-diaminotoluene results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression EXP 2,6-diaminotoluene results in decreased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP 2,6-diaminotoluene results in decreased expression of FAS mRNA CTD PMID:17070881 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2,6-diaminotoluene results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 increases expression EXP 2,6-diaminotoluene results in increased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression EXP 2,6-diaminotoluene results in decreased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2,6-diaminotoluene results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP 2,6-diaminotoluene results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Olr37 olfactory receptor 37 decreases expression EXP 2,6-diaminotoluene results in decreased expression of OLR37 mRNA CTD PMID:17070881 NCBI chr 1:154,089,219...154,090,184 JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 affects expression EXP 2,6-diaminotoluene affects the expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP 2,6-diaminotoluene results in increased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP 2,6-diaminotoluene results in increased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2,6-diaminotoluene results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376 		JBrowse link
G Sulf2 sulfatase 2 increases expression EXP 2,6-diaminotoluene results in increased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,6-diaminotoluene results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP 2,6-diaminotoluene results in increased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        fuel additive 3129
          toluene 3119
            2,6-diaminotoluene 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  cyclic hydrocarbon 17069
                                    monocyclic hydrocarbon 5845
                                      annulene 5672
                                        aromatic annulene 5672
                                          benzene 5672
                                            alkylbenzene 3388
                                              methylbenzene 3254
                                                toluene 3119
                                                  2,6-diaminotoluene 43
paths to the root