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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,6-diaminotoluene
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Accession:CHEBI:76288 term browser browse the term
Definition:A diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups.
Synonyms:exact_synonym: 2-methylbenzene-1,3-diamine
 related_synonym: 2,6-DAT;   2,6-diamino-1-methylbenzene;   2,6-toluylenediamine;   2,6-tolylenediamine;   2-methyl-1,3-benzenediamine;   2-methyl-1,3-phenylenediamine;   2-methyl-m-phenylenediamine;   EINECS 212-513-9;   Formula=C7H10N2;   InChI=1S/C7H10N2/c1-5-6(8)3-2-4-7(5)9/h2-4H,8-9H2,1H3;   InChIKey=RLYCRLGLCUXUPO-UHFFFAOYSA-N;   SMILES=Cc1c(N)cccc1N;   o-toluene diamine;   toluene-2,6-diamine
 xref: CAS:823-40-5;   HMDB:HMDB0041801
 xref_mesh: MESH:C025235
 xref: PMID:1747922;   PMID:20026473;   PMID:2575496;   PMID:7586147;   PMID:7678174;   PMID:7761993;   Reaxys:2079476


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2,6-diaminotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases expression EXP 2,6-diaminotoluene results in decreased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase increases expression EXP 2,6-diaminotoluene results in increased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:41,752,894...41,798,427
Ensembl chr13:41,752,875...41,798,427 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression EXP 2,6-diaminotoluene results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:142,224,493...142,233,898 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2,6-diaminotoluene results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:86,176,767...86,178,819
Ensembl chr13:86,174,741...86,179,410 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2,6-diaminotoluene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:103,389,783...103,405,346 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 2,6-diaminotoluene results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression EXP 2,6-diaminotoluene results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G C7 complement C7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672 		JBrowse link
G Cblc Cbl proto-oncogene C decreases expression EXP 2,6-diaminotoluene results in decreased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:88,567,932...88,584,709 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2,6-diaminotoluene results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cd276 Cd276 molecule decreases expression EXP 2,6-diaminotoluene results in decreased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP 2,6-diaminotoluene results in increased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2,6-diaminotoluene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137 		JBrowse link
G Cryab crystallin, alpha B decreases expression EXP 2,6-diaminotoluene results in decreased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP 2,6-diaminotoluene results in decreased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2,6-diaminotoluene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:12,194,567...12,209,495
Ensembl chr 7:12,195,022...12,209,965 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2,6-diaminotoluene results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:237,327,766...237,460,626 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression EXP 2,6-diaminotoluene results in decreased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702 		JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP 2,6-diaminotoluene results in decreased expression of FAS mRNA CTD PMID:17070881 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2,6-diaminotoluene results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:125,103,975...125,369,690
Ensembl chr  X:125,103,782...125,369,679 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 increases expression EXP 2,6-diaminotoluene results in increased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:831,407...850,950
Ensembl chr 7:831,421...850,873 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression EXP 2,6-diaminotoluene results in decreased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2,6-diaminotoluene results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP 2,6-diaminotoluene results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Or2at1 olfactory receptor family 2 subfamily AT member 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of OR2AT1 mRNA CTD PMID:17070881 NCBI chr 1:163,501,335...163,502,300
Ensembl chr 1:163,501,335...163,502,300 		JBrowse link
G Pbsn probasin increases expression EXP 2,6-diaminotoluene results in increased expression of PBSN mRNA CTD PMID:17070881 NCBI chr  X:45,792,738...45,807,983
Ensembl chr  X:45,792,738...45,807,983 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621 		JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 affects expression EXP 2,6-diaminotoluene affects the expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:51,278,024...51,298,209
Ensembl chr15:51,280,149...51,298,209 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:107,452,044...107,510,958
Ensembl chr  X:107,452,044...107,457,681 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP 2,6-diaminotoluene results in increased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP 2,6-diaminotoluene results in increased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2,6-diaminotoluene results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:52,072,012...52,929,852
Ensembl chr17:52,072,052...52,930,281 		JBrowse link
G Sulf2 sulfatase 2 increases expression EXP 2,6-diaminotoluene results in increased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,6-diaminotoluene results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP 2,6-diaminotoluene results in increased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:117,034,517...117,065,294 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      chemical role 20397
        fuel additive 3478
          toluene 3467
            2,6-diaminotoluene 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20565
                        hydrogen molecular entity 20549
                          hydrides 19684
                            organic hydride 19084
                              organic fundamental parent 19071
                                hydrocarbon 18736
                                  cyclic hydrocarbon 17326
                                    monocyclic hydrocarbon 6381
                                      annulene 6041
                                        aromatic annulene 6043
                                          benzene 6043
                                            alkylbenzene 3755
                                              methylbenzene 3593
                                                toluene 3467
                                                  2,6-diaminotoluene 43
paths to the root