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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,6-diaminotoluene
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Accession:CHEBI:76288 term browser browse the term
Definition:A diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups.
Synonyms:exact_synonym: 2-methylbenzene-1,3-diamine
 related_synonym: 2,6-DAT;   2,6-diamino-1-methylbenzene;   2,6-toluylenediamine;   2,6-tolylenediamine;   2-methyl-1,3-benzenediamine;   2-methyl-1,3-phenylenediamine;   2-methyl-m-phenylenediamine;   EINECS 212-513-9;   Formula=C7H10N2;   InChI=1S/C7H10N2/c1-5-6(8)3-2-4-7(5)9/h2-4H,8-9H2,1H3;   InChIKey=RLYCRLGLCUXUPO-UHFFFAOYSA-N;   SMILES=Cc1c(N)cccc1N;   o-toluene diamine;   toluene-2,6-diamine
 xref: CAS:823-40-5;   HMDB:HMDB0041801
 xref_mesh: MESH:C025235
 xref: PMID:1747922;   PMID:20026473;   PMID:2575496;   PMID:7586147;   PMID:7678174;   PMID:7761993;   Reaxys:2079476

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2,6-diaminotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression EXP 2,6-diaminotoluene results in decreased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase increases expression EXP 2,6-diaminotoluene results in increased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression EXP 2,6-diaminotoluene results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2,6-diaminotoluene results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of ALDH1A4 mRNA CTD PMID:17070881 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2,6-diaminotoluene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 2,6-diaminotoluene results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression EXP 2,6-diaminotoluene results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982 		JBrowse link
G C7 complement C7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729 		JBrowse link
G Cblc Cbl proto-oncogene C decreases expression EXP 2,6-diaminotoluene results in decreased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2,6-diaminotoluene results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Cd276 Cd276 molecule decreases expression EXP 2,6-diaminotoluene results in decreased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP 2,6-diaminotoluene results in increased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2,6-diaminotoluene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:71,709,174...72,167,413
Ensembl chr 7:71,709,157...72,167,417 		JBrowse link
G Cryab crystallin, alpha B decreases expression EXP 2,6-diaminotoluene results in decreased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP 2,6-diaminotoluene results in decreased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2,6-diaminotoluene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:14,559,806...14,574,345
Ensembl chr 7:14,529,482...14,574,361 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2,6-diaminotoluene results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression EXP 2,6-diaminotoluene results in decreased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216 		JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP 2,6-diaminotoluene results in decreased expression of FAS mRNA CTD PMID:17070881 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2,6-diaminotoluene results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP 2,6-diaminotoluene results in decreased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 increases expression EXP 2,6-diaminotoluene results in increased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression EXP 2,6-diaminotoluene results in decreased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2,6-diaminotoluene results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP 2,6-diaminotoluene results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Olr37 olfactory receptor 37 decreases expression EXP 2,6-diaminotoluene results in decreased expression of OLR37 mRNA CTD PMID:17070881 NCBI chr 1:164,755,094...164,756,059 JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression EXP 2,6-diaminotoluene results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001 		JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 affects expression EXP 2,6-diaminotoluene affects the expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:51,465,148...51,485,562
Ensembl chr15:51,465,148...51,485,692 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP 2,6-diaminotoluene results in decreased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP 2,6-diaminotoluene results in increased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP 2,6-diaminotoluene results in increased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2,6-diaminotoluene results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:49,991,314...51,030,950 JBrowse link
G Sulf2 sulfatase 2 increases expression EXP 2,6-diaminotoluene results in increased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,6-diaminotoluene results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP 2,6-diaminotoluene results in increased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      chemical role 19309
        fuel additive 3084
          toluene 3074
            2,6-diaminotoluene 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            organic hydride 18291
                              organic fundamental parent 18291
                                hydrocarbon 18015
                                  cyclic hydrocarbon 17080
                                    monocyclic hydrocarbon 5772
                                      annulene 5596
                                        aromatic annulene 5596
                                          benzene 5596
                                            alkylbenzene 3348
                                              methylbenzene 3211
                                                toluene 3074
                                                  2,6-diaminotoluene 43
paths to the root