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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tepoxalin
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Accession:CHEBI:76277 term browser browse the term
Definition:A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs.
Synonyms:exact_synonym: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
 related_synonym: 5-(p-Chlorophenyl)-1-(p-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid;   Formula=C20H20ClN3O3;   InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3;   InChIKey=XYKWNRUXCOIMFZ-UHFFFAOYSA-N;   ORF 20485;   RWJ 20485;   SMILES=COc1ccc(cc1)-n1nc(CCC(=O)N(C)O)cc1-c1ccc(Cl)cc1;   Zubrin;   tepoxalina;   tepoxaline;   tepoxaliume
 xref: CAS:103475-41-8;   KEGG:C18362;   KEGG:D06075
 xref_mesh: MESH:C073135
 xref: PMID:16343292;   PMID:19161461;   PMID:19175721;   PMID:19552701;   PMID:19566476;   PMID:19624842;   PMID:20000343;   PMID:20807147;   PMID:21036634;   PMID:21062309;   PMID:21348304;   PMID:21497474;   PMID:21565533;   PMID:21569197;   PMID:21962280;   PMID:22091562;   PMID:22240988;   PMID:22287649;   PMID:22726277;   PMID:22986275;   PMID:23349526;   PMID:23718664;   PMID:23802664;   PMID:7652766;   PMID:9703407;   Patent:WO2007022427;   Reaxys:4334297;   VSDB:1877;   Wikipedia:Tepoxalin


show annotations for term's descendants           Sort by:
tepoxalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions		 ISO
EXP		 tepoxalin results in decreased activity of ALOX5 protein
[tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]		 CTD PMID:9223651 PMID:12629151 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] CTD PMID:8566054 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO tepoxalin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA] CTD PMID:7759567 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:8566054 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Sele selectin E multiple interactions ISO tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of SELE mRNA] CTD PMID:8566054 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        immunomodulator 15068
          tepoxalin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              hydroxamic acid 6340
                                                tepoxalin 5
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