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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:76277 term browser browse the term
Definition:A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs.
Synonyms:exact_synonym: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
 related_synonym: 5-(p-Chlorophenyl)-1-(p-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid;   Formula=C20H20ClN3O3;   InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3;   InChIKey=XYKWNRUXCOIMFZ-UHFFFAOYSA-N;   ORF 20485;   RWJ 20485;   SMILES=COc1ccc(cc1)-n1nc(CCC(=O)N(C)O)cc1-c1ccc(Cl)cc1;   Zubrin;   tepoxalina;   tepoxaline;   tepoxaliume
 xref: CAS:103475-41-8;   KEGG:C18362;   KEGG:D06075
 xref_mesh: MESH:C073135
 xref: PMID:16343292;   PMID:19161461;   PMID:19175721;   PMID:19552701;   PMID:19566476;   PMID:19624842;   PMID:20000343;   PMID:20807147;   PMID:21036634;   PMID:21062309;   PMID:21348304;   PMID:21497474;   PMID:21565533;   PMID:21569197;   PMID:21962280;   PMID:22091562;   PMID:22240988;   PMID:22287649;   PMID:22726277;   PMID:22986275;   PMID:23349526;   PMID:23718664;   PMID:23802664;   PMID:7652766;   PMID:9703407;   Patent:WO2007022427;   Reaxys:4334297;   VSDB:1877;   Wikipedia:Tepoxalin

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tepoxalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions
tepoxalin results in decreased activity of ALOX5 protein
[tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]
CTD PMID:9223651 PMID:12629151 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] CTD PMID:8566054 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tepoxalin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA] CTD PMID:7759567 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:8566054 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Sele selectin E multiple interactions ISO tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of SELE mRNA] CTD PMID:8566054 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        immunomodulator 15068
          tepoxalin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic group 18957
                              organic divalent group 18938
                                organodiyl group 18938
                                  carbonyl group 18890
                                    carbonyl compound 18890
                                      carboxylic acid 18611
                                        carboacyl group 17702
                                          univalent carboacyl group 17702
                                            carbamoyl group 17547
                                              carboxamide 17547
                                                hydroxamic acid 6331
                                                  tepoxalin 5
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