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Accession:CHEBI:76277 term browser browse the term
Definition:A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs.
Synonyms:exact_synonym: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
 related_synonym: 5-(p-Chlorophenyl)-1-(p-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid;   Formula=C20H20ClN3O3;   InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3;   InChIKey=XYKWNRUXCOIMFZ-UHFFFAOYSA-N;   ORF 20485;   RWJ 20485;   SMILES=COc1ccc(cc1)-n1nc(CCC(=O)N(C)O)cc1-c1ccc(Cl)cc1;   Zubrin;   tepoxalina;   tepoxaline;   tepoxaliume
 xref: CAS:103475-41-8 "ChemIDplus";   CAS:103475-41-8 "KEGG COMPOUND";   CAS:103475-41-8 "KEGG DRUG";   KEGG:C18362;   KEGG:D06075
 xref_mesh: MESH:C073135
 xref: PMID:16343292 "Europe PMC";   PMID:19161461 "Europe PMC";   PMID:19175721 "Europe PMC";   PMID:19552701 "Europe PMC";   PMID:19566476 "Europe PMC";   PMID:19624842 "Europe PMC";   PMID:20000343 "Europe PMC";   PMID:20807147 "Europe PMC";   PMID:21036634 "Europe PMC";   PMID:21062309 "Europe PMC";   PMID:21348304 "Europe PMC";   PMID:21497474 "Europe PMC";   PMID:21565533 "Europe PMC";   PMID:21569197 "Europe PMC";   PMID:21962280 "Europe PMC";   PMID:22091562 "Europe PMC";   PMID:22240988 "Europe PMC";   PMID:22287649 "Europe PMC";   PMID:22726277 "Europe PMC";   PMID:22986275 "Europe PMC";   PMID:23349526 "Europe PMC";   PMID:23718664 "Europe PMC";   PMID:23802664 "Europe PMC";   PMID:7652766 "Europe PMC";   PMID:9703407 "Europe PMC";   Patent:WO2007022427;   Reaxys:4334297 "Reaxys";   VSDB:1877;   Wikipedia:Tepoxalin

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tepoxalin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        immunomodulator 12649
          tepoxalin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                hydroxamic acid 6228
                                                  tepoxalin 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.