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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:norethisterone
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Accession:CHEBI:7627 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.
Synonyms:exact_synonym: (17alpha)-17-hydroxy-19-norpregn-4-en-20-yn-3-one;   17-ethynyl-17beta-hydroxyestr-4-en-3-one
 related_synonym: (17alpha)-17-ethynyl-17-hydroxyestra-4,8(14),9-trien-3-one;   17-alpha-ethynyl-17-hydroxy-4-estren-3-one;   17-alpha-ethynyl-19-norandrost-4-en-17-beta-ol-3-one;   17-alpha-ethynyl-19-nortestosterone;   17-alpha-ethynyl-4-estren-17-ol-3-one;   17-beta-hydroxy-19-norpregn-4-en-20-yn-3-one;   17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one;   17-hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one;   17alpha-ethinyl-19-nortestosterone;   17alpha-ethinylestra-4-en-17beta-ol-3-one;   17alpha-ethynyl-17-hydroxy-4-estren-3-one;   17alpha-ethynyl-17beta-hydroxy-19-norandrost-4-en-3-one;   17alpha-ethynyl-19-nor-4-androsten-17beta-ol-3-one;   17alpha-ethynyl-19-norandrost-4-en-17beta-ol-3-one;   17alpha-ethynyl-19-nortestosterone;   17alpha-ethynyl-4-estren-17-ol-3-one;   17beta-hydroxy-19-norpregn-4-en-20-yn-3-one;   19-Nor-17alpha-ethynyl-17beta-hydroxy-4-androsten-3-one;   19-Norethisterone;   19-nor-17-alpha-ethynyl-17-beta-hydroxy-4-androsten-3-one;   19-nor-17-alpha-ethynylandrosten-17-beta-ol-3-one;   19-nor-17-alpha-ethynyltestosterone;   19-nor-17alpha-ethynylandrosten-17beta-ol-3-one;   19-nor-17alpha-ethynyltestosterone;   19-nor-ethindrone;   4-estren-17alpha-ethynyl-17beta-ol-3-one;   Camila;   Conludag;   Formula=C20H26O2;   InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1;   InChIKey=VIKNJXKGJWUCNN-XGXHKTLJSA-N;   Micronor;   Micronovum;   Mini-pe;   Mini-pill;   Norcolut;   Norethindrone;   Norethisteron;   Noriday;   Norluten;   Norlutin;   Primolut-N;   SMILES=C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C;   Utovlan;   norethisteronum;   noretisterona
 alt_id: CHEBI:44349
 xref: Beilstein:1915671;   CAS:68-22-4;   DrugBank:DB00717;   Drug_Central:1962;   HMDB:HMDB0014855;   KEGG:C05028;   KEGG:D00182;   LIPID_MAPS_instance:LMST02030097
 xref_mesh: MESH:D009640
 xref: PDBeChem:NDR;   PMID:120838;   PMID:21860523;   PMID:24019188;   Patent:US2744122;   Patent:US2849462;   Reaxys:1915671;   Wikipedia:Norethisterone


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norethisterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Norethindrone results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Norethindrone results in increased expression of ABCB1 mRNA CTD PMID:15290871 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Norethindrone results in decreased activity of AKR1C3 protein CTD PMID:21182831 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Norethindrone binds to AR protein
Norethindrone binds to and results in decreased activity of AR protein; Norethindrone binds to and results in increased activity of AR protein
CTD PMID:14565775, PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases secretion ISO Norethindrone results in increased secretion of BGLAP protein CTD PMID:8053399 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
EXP
ISO
Norethindrone results in increased activity of ESR1 protein
Norethindrone binds to and results in increased activity of ESR1 protein
CTD PMID:11750080, PMID:12504345, PMID:25012808, PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Norethindrone binds to and results in increased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F10 coagulation factor X multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F10 protein CTD PMID:14561536 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F7 protein CTD PMID:14561536 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase increases activity ISO Norethindrone results in increased activity of FASN protein CTD PMID:15870863 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:14561536 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:14561536 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:14561536 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Norethindrone results in increased phosphorylation of H2AX protein CTD PMID:15905198 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Norethindrone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Norethindrone binds to and results in increased activity of PGR protein CTD PMID:15189034, PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plg plasminogen multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG protein CTD PMID:14561536 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC protein CTD PMID:14561536 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINC1 protein CTD PMID:14561536 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINE1 protein CTD PMID:14561536 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Norethindrone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Norethindrone results in increased expression of and results in increased activity of TP53 protein CTD PMID:15905198 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Norethindrone results in increased expression of VEGFA mRNA; Norethindrone results in increased expression of VEGFA mRNA alternative form CTD PMID:17010073 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        organic group 18495
          3-oxo-Delta(4)-steroid group 7935
            3-oxo-Delta(4) steroid 7935
              norethisterone 26
                norethisterone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxo steroid 9276
                                          3-oxo steroid 8806
                                            3-oxo-Delta(4) steroid 7935
                                              norethisterone 26
                                                norethisterone acetate 0
paths to the root

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