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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:norethisterone
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Accession:CHEBI:7627 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.
Synonyms:exact_synonym: (17alpha)-17-hydroxy-19-norpregn-4-en-20-yn-3-one;   17-ethynyl-17beta-hydroxyestr-4-en-3-one
 related_synonym: (17alpha)-17-ethynyl-17-hydroxyestra-4,8(14),9-trien-3-one;   17-alpha-ethynyl-17-hydroxy-4-estren-3-one;   17-alpha-ethynyl-19-norandrost-4-en-17-beta-ol-3-one;   17-alpha-ethynyl-19-nortestosterone;   17-alpha-ethynyl-4-estren-17-ol-3-one;   17-beta-hydroxy-19-norpregn-4-en-20-yn-3-one;   17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one;   17-hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one;   17alpha-ethinyl-19-nortestosterone;   17alpha-ethinylestra-4-en-17beta-ol-3-one;   17alpha-ethynyl-17-hydroxy-4-estren-3-one;   17alpha-ethynyl-17beta-hydroxy-19-norandrost-4-en-3-one;   17alpha-ethynyl-19-nor-4-androsten-17beta-ol-3-one;   17alpha-ethynyl-19-norandrost-4-en-17beta-ol-3-one;   17alpha-ethynyl-19-nortestosterone;   17alpha-ethynyl-4-estren-17-ol-3-one;   17beta-hydroxy-19-norpregn-4-en-20-yn-3-one;   19-Nor-17alpha-ethynyl-17beta-hydroxy-4-androsten-3-one;   19-Norethisterone;   19-nor-17-alpha-ethynyl-17-beta-hydroxy-4-androsten-3-one;   19-nor-17-alpha-ethynylandrosten-17-beta-ol-3-one;   19-nor-17-alpha-ethynyltestosterone;   19-nor-17alpha-ethynylandrosten-17beta-ol-3-one;   19-nor-17alpha-ethynyltestosterone;   19-nor-ethindrone;   4-estren-17alpha-ethynyl-17beta-ol-3-one;   Camila;   Conludag;   Formula=C20H26O2;   InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1;   InChIKey=VIKNJXKGJWUCNN-XGXHKTLJSA-N;   Micronor;   Micronovum;   Mini-pe;   Mini-pill;   Norcolut;   Norethindrone;   Norethisteron;   Noriday;   Norluten;   Norlutin;   Primolut-N;   SMILES=C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C;   Utovlan;   norethisteronum;   noretisterona
 alt_id: CHEBI:44349
 xref: Beilstein:1915671;   CAS:68-22-4;   DrugBank:DB00717;   Drug_Central:1962;   HMDB:HMDB0014855;   KEGG:C05028;   KEGG:D00182;   LIPID_MAPS_instance:LMST02030097
 xref_mesh: MESH:D009640
 xref: PDBeChem:NDR;   PMID:120838;   PMID:21860523;   PMID:24019188;   Patent:US2744122;   Patent:US2849462;   Reaxys:1915671;   Wikipedia:Norethisterone


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norethisterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Norethindrone results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Norethindrone results in increased expression of ABCB1 mRNA CTD PMID:15290871 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Norethindrone results in decreased activity of AKR1C3 protein CTD PMID:21182831 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Norethindrone binds to AR protein
Norethindrone binds to and results in decreased activity of AR protein; Norethindrone binds to and results in increased activity of AR protein
CTD PMID:14565775 PMID:25752796 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases secretion ISO Norethindrone results in increased secretion of BGLAP protein CTD PMID:8053399 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
EXP
ISO
Norethindrone results in increased activity of ESR1 protein
ESR1 protein affects the reaction [Norethindrone results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Norethindrone results in increased expression of SGK1 mRNA]; Norethindrone binds to and results in increased activity of ESR1 protein
CTD PMID:11750080 PMID:12504345 PMID:25012808 PMID:25752796 PMID:33049310 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Norethindrone binds to and results in increased activity of ESR2 protein CTD PMID:25752796 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F10 coagulation factor X multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F10 protein CTD PMID:14561536 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F7 protein CTD PMID:14561536 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fasn fatty acid synthase increases activity ISO Norethindrone results in increased activity of FASN protein CTD PMID:15870863 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:14561536 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:14561536 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:14561536 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [Norethindrone results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Norethindrone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Norethindrone results in increased phosphorylation of H2AX protein CTD PMID:15905198 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Norethindrone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Norethindrone results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Norethindrone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Norethindrone binds to and results in increased activity of PGR protein CTD PMID:15189034 PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plg plasminogen multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG protein CTD PMID:14561536 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Norethindrone binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC protein CTD PMID:14561536 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Norethindrone results in decreased activity of AKR1C1 protein CTD PMID:21182831 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINC1 protein CTD PMID:14561536 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINE1 protein CTD PMID:14561536 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO Norethindrone results in increased expression of SGK1 mRNA
ESR1 protein affects the reaction [Norethindrone results in increased expression of SGK1 mRNA]; Fulvestrant inhibits the reaction [Norethindrone results in increased expression of SGK1 mRNA]
CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Norethindrone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Norethindrone binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Norethindrone binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Norethindrone results in increased expression of and results in increased activity of TP53 protein CTD PMID:15905198 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Norethindrone results in increased expression of VEGFA mRNA; Norethindrone results in increased expression of VEGFA mRNA alternative form CTD PMID:17010073 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        organic group 18728
          3-oxo-Delta(4)-steroid group 8423
            3-oxo-Delta(4) steroid 8423
              norethisterone 34
                norethisterone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxo steroid 9718
                                          3-oxo steroid 9281
                                            3-oxo-Delta(4) steroid 8423
                                              norethisterone 34
                                                norethisterone acetate 0
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