Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:oxyphenbutazone
go back to main search page
Accession:CHEBI:76258 term browser browse the term
Definition:A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.
Synonyms:related_synonym: 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine;   1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine;   3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene;   4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;   4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;   4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine;   Formula=C19H20N2O3;   Hydroxyphenylbutazon;   InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3;   InChIKey=HFHZKZSRXITVMK-UHFFFAOYSA-N;   Oxi-fenibutol;   Oxifenylbutazon;   Oxiphenbutazonum;   Oxyphenylbutazone;   SMILES=CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1;   oxifenbutazona;   oxyphenbutazonum;   p-Hydroxyphenylbutazone;   p-Oxyphenylbutazone
 xref: CAS:129-20-4 "ChemIDplus";   CAS:129-20-4 "KEGG COMPOUND";   CAS:129-20-4 "KEGG DRUG";   CAS:129-20-4 "NIST Chemistry WebBook";   DrugBank:DB03585;   Drug_Central:2036 "DrugCentral";   KEGG:C19494;   KEGG:D08324;   LINCS:LSM-5029
 xref_mesh: MESH:D010113
 xref: PMID:1222682 "Europe PMC";   PMID:141661 "Europe PMC";   PMID:14345781 "Europe PMC";   PMID:18963985 "Europe PMC";   PMID:19161668 "Europe PMC";   PMID:20299217 "Europe PMC";   PMID:21428758 "Europe PMC";   PMID:23012453 "Europe PMC";   PMID:23983013 "Europe PMC";   PMID:2862290 "Europe PMC";   PMID:380595 "Europe PMC";   PMID:501546 "Europe PMC";   PMID:546857 "Europe PMC";   PMID:6617711 "Europe PMC";   PMID:6860567 "Europe PMC";   PMID:6894379 "Europe PMC";   PMID:7001487 "Europe PMC";   PMID:7309664 "Europe PMC";   PMID:7368966 "Europe PMC";   PMID:766157 "Europe PMC";   PMID:835859 "Europe PMC";   Patent:EP642336;   Patent:US2008014272;   Patent:WO2005107748;   Reaxys:307474 "Reaxys";   Wikipedia:Oxyphenbutazone


show annotations for term's descendants       view all columns           Sort by:
 
oxyphenbutazone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          oxyphenbutazone 1
            oxyphenbutazone hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteromonocyclic compound 16249
                                    diazolidine 564
                                      pyrazolidines 28
                                        phenylbutazone 20
                                          oxyphenbutazone 1
                                            oxyphenbutazone hydrate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.