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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation decreases expression |
EXP |
NDGA increases phosphorylation in liver of high fructose fed rats NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 PMID:26394137 |
RGD:329955565, RGD:329955565 |
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
decreases expression |
EXP |
NDGA decreases expression of Acacb protein in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
NDGA increases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
EXP |
NDGA increases phosphorylation in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Cd36 |
CD36 molecule |
increases expression |
EXP |
NDGA increases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
increases expression |
EXP |
NDGA increases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
decreases expression |
EXP |
NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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G |
Fabp2 |
fatty acid binding protein 2 |
increases expression |
EXP |
NDGA increases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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G |
Fasn |
fatty acid synthase |
decreases expression |
EXP |
NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression |
EXP |
NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
increases phosphorylation |
EXP |
NDGA increases phosphorylation in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
EXP |
NDGA increases phosphorylation in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mlxipl |
MLX interacting protein-like |
decreases expression |
EXP |
NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
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G |
Mlycd |
malonyl-CoA decarboxylase |
increases expression |
EXP |
NDGA increases expression of Mlycd protein in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
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G |
Pklr |
pyruvate kinase L/R |
decreases expression |
EXP |
NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
NDGA increases expression of Ppara protein in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
increases phosphorylation |
EXP |
NDGA increases phosphorylation in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Scd |
stearoyl-CoA desaturase |
decreases expression |
EXP |
NDGA decreases expression of mRNA, protein in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
decreases expression |
EXP |
NDGA decreases expression of mRNA in liver of high fructose fed rats |
RGD |
PMID:26394137 |
RGD:329955565 |
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
Masoprocol binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
Masoprocol results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:19503098 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alk |
ALK receptor tyrosine kinase |
multiple interactions decreases activity |
ISO |
Masoprocol affects the phosphorylation of and affects the activity of ALK protein mutant form Masoprocol results in decreased activity of ALK protein |
CTD |
PMID:19503098 |
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NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
multiple interactions decreases activity |
ISO EXP |
Masoprocol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] Masoprocol results in decreased activity of ALOX12 protein |
CTD |
PMID:3928952 PMID:6240459 PMID:9258337 PMID:17027136 PMID:23238474 |
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NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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G |
Alox15 |
arachidonate 15-lipoxygenase |
multiple interactions decreases activity |
EXP ISO |
Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] Masoprocol results in decreased activity of ALOX15 protein [Masoprocol results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid |
CTD |
PMID:15574791 PMID:18984061 |
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NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Alox5 |
arachidonate 5-lipoxygenase |
affects response to substance decreases activity multiple interactions |
ISO EXP |
ALOX5 protein affects the susceptibility to Masoprocol Masoprocol results in decreased activity of ALOX5 protein Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] [Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; Masoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] |
CTD |
PMID:2724698 PMID:2849922 PMID:3928952 PMID:6240459 PMID:10698703 PMID:18083043 PMID:19503098 More...
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Ar |
androgen receptor |
affects binding |
EXP |
Masoprocol binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Masoprocol results in increased expression of BAX protein MYC affects the reaction [Masoprocol results in increased expression of BAX protein] |
CTD |
PMID:15034932 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein |
CTD |
PMID:17645780 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases activity |
ISO EXP |
Masoprocol results in increased cleavage of CASP3 protein Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased cleavage of and results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of CASP3 protein] acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Masoprocol results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein] [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:10203695 PMID:10653524 PMID:11470254 PMID:15034932 PMID:17645780 PMID:17651887 PMID:18645000 PMID:19503098 PMID:22308955 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases expression |
ISO |
[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein] Masoprocol results in increased expression of CASP8 protein |
CTD |
PMID:10203695 PMID:17645780 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
Masoprocol results in increased activity of CASP9 protein |
CTD |
PMID:15034932 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] |
CTD |
PMID:18083043 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Masoprocol results in decreased expression of CCND1 protein |
CTD |
PMID:11953870 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
decreases methylation increases expression |
ISO |
Masoprocol results in decreased methylation of CDH1 promoter Masoprocol results in increased expression of CDH1 mRNA; Masoprocol results in increased expression of CDH1 protein |
CTD |
PMID:18418215 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
decreases methylation increases expression |
ISO |
Masoprocol results in decreased methylation of CDKN2A promoter Masoprocol results in increased expression of CDKN2A mRNA; Masoprocol results in increased expression of CDKN2A protein |
CTD |
PMID:18164318 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form] |
CTD |
PMID:17395008 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB mRNA]; Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:8591993 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
Masoprocol results in decreased activity of DIO1 protein |
CTD |
PMID:30561685 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases activity |
ISO |
Masoprocol results in decreased activity of DIO2 protein |
CTD |
PMID:30561685 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dio3 |
iodothyronine deiodinase 3 |
decreases activity |
ISO |
Masoprocol results in decreased activity of DIO3 protein |
CTD |
PMID:30561685 |
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NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein] |
CTD |
PMID:18645000 |
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Masoprocol binds to and results in increased activity of ESR1 protein |
CTD |
PMID:19063592 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Masoprocol results in increased expression of FAS protein |
CTD |
PMID:17645780 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO EXP |
Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein] Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of FASLG protein] |
CTD |
PMID:10203695 PMID:17651887 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:17395008 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]] |
CTD |
PMID:10692565 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fpr1 |
formyl peptide receptor 1 |
decreases activity |
ISO |
Masoprocol results in decreased activity of FPR1 protein |
CTD |
PMID:17520823 |
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NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP ISO |
Masoprocol results in increased expression of HMOX1 mRNA; Masoprocol results in increased expression of HMOX1 protein |
CTD |
PMID:18852027 PMID:23942037 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
multiple interactions increases expression increases activity |
ISO |
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased expression of HSD11B2 mRNA]; [Masoprocol co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; Masoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]; Masoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein] |
CTD |
PMID:10377029 PMID:18032417 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] |
CTD |
PMID:18491370 PMID:18645000 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions decreases activity |
ISO |
Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]; Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]; Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] Masoprocol results in decreased activity of IGF1R protein |
CTD |
PMID:18491370 PMID:18645000 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Il1b |
interleukin 1 beta |
multiple interactions decreases response to substance |
ISO |
Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] Masoprocol results in decreased susceptibility to IL1B protein Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] |
CTD |
PMID:8186192 PMID:12573452 PMID:21211511 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:8186192 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression multiple interactions |
ISO |
Masoprocol results in decreased expression of JUN mRNA Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]] |
CTD |
PMID:10692565 PMID:15034932 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] |
CTD |
PMID:18984061 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Krt1 |
keratin 1 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Calcium results in increased expression of KRT1 mRNA] |
CTD |
PMID:12069687 |
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NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Testosterone] |
CTD |
PMID:6430271 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein] Masoprocol results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:17395008 PMID:19503098 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO |
Masoprocol results in decreased phosphorylation of MAPK3 protein Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:17395008 PMID:19503098 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form] |
CTD |
PMID:17395008 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form] |
CTD |
PMID:17395008 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein] |
CTD |
PMID:17395008 PMID:21211511 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression multiple interactions |
ISO |
Masoprocol results in increased expression of MYC protein MYC affects the reaction [Masoprocol results in increased expression of BAX protein]; MYC affects the reaction [Masoprocol results in increased expression of MYC protein]; MYC affects the reaction [Masoprocol results in increased expression of TP53 protein] |
CTD |
PMID:15034932 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Masoprocol affects the localization of and results in increased activity of NFE2L2 protein |
CTD |
PMID:18852027 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form] |
CTD |
PMID:17395008 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein] |
CTD |
PMID:17651887 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Ngfr |
nerve growth factor receptor |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] |
CTD |
PMID:17651887 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA] |
CTD |
PMID:22037733 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] |
CTD |
PMID:2105358 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Otc |
ornithine transcarbamylase |
multiple interactions |
EXP |
Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein] |
CTD |
PMID:3097147 |
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NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
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Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Masoprocol affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein] |
CTD |
PMID:25770929 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] |
CTD |
PMID:28111842 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Prl |
prolactin |
multiple interactions |
EXP |
Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein] |
CTD |
PMID:3097147 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:7575673 PMID:12573452 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
Masoprocol results in decreased phosphorylation of RB1 protein |
CTD |
PMID:18164318 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form] |
CTD |
PMID:17395008 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Shbg |
sex hormone binding globulin |
affects binding |
ISO |
Masoprocol binds to SHBG protein |
CTD |
PMID:25349334 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] |
CTD |
PMID:17962351 |
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NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] |
CTD |
PMID:8760145 PMID:12031898 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
Masoprocol results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:19503098 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA] |
CTD |
PMID:19194550 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf |
tumor necrosis factor |
multiple interactions decreases response to substance |
ISO |
Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] Masoprocol results in decreased susceptibility to TNF protein |
CTD |
PMID:8186192 PMID:8760145 PMID:21211511 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP10 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:17645780 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
MYC affects the reaction [Masoprocol results in increased expression of TP53 protein] |
CTD |
PMID:15034932 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium] |
CTD |
PMID:21453681 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
EXP |
Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] |
CTD |
PMID:17962351 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of Masoprocol |
CTD |
PMID:14557274 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Masoprocol |
CTD |
PMID:14557274 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein] |
CTD |
PMID:17520823 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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