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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(S)-ketorolac
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Accession:CHEBI:76228 term browser browse the term
Definition:A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known simply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Synonyms:exact_synonym: (1S)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
 related_synonym: (-)-ketorolac;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1;   InChIKey=OZWKMVRBQXNZKK-NSHDSACASA-N;   SMILES=OC(=O)[C@H]1CCn2c1ccc2C(=O)c1ccccc1
 xref: CAS:66635-92-5;   PMID:10027870;   PMID:10223774;   PMID:10593468;   PMID:15584071;   PMID:17456651;   PMID:19281996;   PMID:23447046;   PMID:9549656;   Reaxys:6064296
 cyclic_relationship: is_enantiomer_of CHEBI:76227


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Term Annotations click to browse term
  CHEBI ontology 0
    role 0
      biological role 0
        pharmacological role 0
          analgesic 0
            (S)-ketorolac 0
              ketorolac 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            organic group 0
                              organic divalent group 0
                                organodiyl group 0
                                  carbonyl group 0
                                    carbonyl compound 0
                                      carboxylic acid 0
                                        monocarboxylic acid 0
                                          5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 0
                                            (S)-ketorolac 0
                                              ketorolac 0
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