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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:norathyriol
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Accession:CHEBI:7622 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.
Synonyms:exact_synonym: 1,3,6,7-tetrahydroxy-9H-xanthen-9-one
 related_synonym: 1,3,6,7-Tetrahydroxyxanthone;   Formula=C13H8O6;   InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H;   InChIKey=ZHTQCPCDXKMMLU-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc1cc(O)c(O)cc1c2=O
 alt_id: CHEBI:66635
 xref: CAS:3542-72-1;   KEGG:C10086;   KNApSAcK:C00002968
 xref_mesh: MESH:C069053
 xref: PMID:13995190;   PMID:15256712;   PMID:20513373;   PMID:22084399;   PMID:23361275;   PMID:7511107;   PMID:9384257;   Patent:CN102657640;   Reaxys:270886


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norathyriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO norathyriol results in increased expression of ABCB1 protein CTD PMID:20513373 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects binding
decreases activity
ISO norathyriol binds to MAPK1 protein
norathyriol results in decreased activity of MAPK1 protein
CTD PMID:22084399 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity ISO norathyriol results in decreased activity of MAPK3 protein CTD PMID:22084399 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] CTD PMID:18393431 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO norathyriol inhibits the reaction [GW0742 results in increased activity of PPARD protein] CTD PMID:18393431 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein] CTD PMID:18393431 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link

Term paths to the root
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  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antineoplastic agent 17001
              norathyriol 6
                tripteroside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        cyclic ketone 13877
                                          xanthones 167
                                            norathyriol 6
                                              tripteroside 0
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